Digital Commons Network^™

Functional Regulation Of Macrophages By Ces1d-Mediated Lipid Signaling In Immunometabolism, Long J Shao, Fathima Elizondo, Feng Gao, Rabie Habib, Xin Li, Katherine Pham, Jazmin Ysaguirre, Maryam Elizondo, Shirindokht Shirazi, Kristin L Eckel-Mahan, Sean Hartig, Huaizhu Wu, Kai Sun

Faculty, Staff and Student Publications

Objective: Macrophage accumulation in metabolically active tissues during obesity is common in both animals and humans, but the lipid signaling mechanisms that trigger macrophage inflammation remain unclear. This study investigates the role of Ces1d, an unconventional lipase, in regulating macrophage inflammation under nutritional stress.

Methods: A myeloid-specific Ces1d knockout (LysM-Cre-Ces1d floxed/floxed, KO) mouse model was used for the studies. For in vitro tests, bone marrow-derived macrophages (BMDMs) from control (Ces1d floxed/floxed, WT) and KO mice were assessed for migration, polarization, and activation. For in vivo experiments, WT and KO mice were induced to obesity via a high-fat diet (HFD) and …

Metabolic Clearance Rate Of Insulin Across The Glucose Tolerance Spectrum By Race And Ethnicity In Youth With Obesity, Wonhee Cho, Fida Bacha, Hala Tfayli, Sojung Lee, Sara F Michaliszyn, Joon Young Kim, Silva Arslanian

Children’s Nutrition Research Center Staff Publications

Objective: Despite β-cell failure in youth with dysglycemia (i.e., impaired glucose tolerance [IGT] and type 2 diabetes), fasting insulin (FI) concentrations are elevated. Herein, we examined the following: 1) metabolic clearance rate of insulin (MCRI) in youth with obesity and normal glucose tolerance (NGT) versus those with IGT versus those with type 2 diabetes; 2) racial and ethnic differences in insulin dynamics; and 3) metabolic/adiposity correlates of MCRI.

Methods: A total of 206 youth underwent assessment of fasting glucose, FI, MCRI and peripheral insulin sensitivity (PIS), first-phase insulin secretion, disposition index, body composition, and abdominal adiposity.

Results: In type 2 …

Defining Lipedema’S Molecular Hallmarks By Multi-Omics Approach For Disease Prediction In Women, Leon G Straub, Jan-Bernd Funcke, Nolwenn Joffin, Chanmin Joung, Sara Al-Ghadban, Shangang Zhao, Qingzhang Zhu, Ilja L Kruglikov, Yi Zhu, Paul R Langlais, Ruth Gordillo, Karen L Herbst, Philipp E Scherer

Children’s Nutrition Research Center Staff Publications

Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of lipedema using an unbiased multi-omics approach. We found adipokine dysregulation in lipedema patients participating in a cross-sectional clinical study (ClinicalTrial.gov, NCT02838277), pointing towards the adipocyte as a key player. Analyses of newly generated transcriptomic (SRA, PRJNA940039) and proteomic (ProteomeXchange, PXD058489) datasets of early- and late-stage lipedema samples revealed a local downregulation of factors involved in inflammation. Concomitantly, factors involved in cellular respiration, oxidative phosphorylation, as well as in mitochondrial …

Nutritional Quality Of Subterranean Clover Cultivars In West Central Spain, B Garcia-Criado, A Garcia-Ciudad, M Rico-Rodriguez, L Garcia-Criado

IGC Proceedings (1977-2023)

The nutritional quality of 61 subterranean clover (Trifolium subterraneum L.) cultivars was studied, during 1982, in the province of Salamanca (semiarid zone of west central Spain). Plant samples were collected at the late-bloom stage and were analyzed for protein, carbohydrates and digestibility. The levels of all these constituents fluctuated within acceptable ranges. Higher relative variability was observed in respect of hemicellulose, protein and lignin, while the digestibility values presented lower relative variability. The latter ranged from 71.1 to 76.1 % with a mean of 73.3%, while protein values ranged from 11.1 to 19.4% with a mean of 14.0%. Chemical …

Effects Of Frequency And Height Of Defoliation On Forage Yield And Crude Protein Content Of Flemingia Macrophylla (Flemingia), E O. Asare

IGC Proceedings (1977-2023)

Defoliation studies were conducted over a period of 3 years on the same stands to determine the effects of 3 heights 5, 20 and 35cm and 3 intervals, 8, 12 and 14 weeks of cutting on leaf dry matter (DM) yield and nutritive value of Flemingia macrophylla (Flemingia) a potential fodder shrub. Both height and interval of cutting had significant effect on leaf DM yield. There was significant interaction between frequency and height of cutting. Leaf DM yield decreased with lowering of cutting height and increased through increasing interval between cuts. The 14-week cutting interval and 35cm cutting height treatment …

A Study Of Phenology, Herbage Yield And Crude Protein Content Of Native Ecotypes Of Red Bromegrasses (Bromus Tomentellus Boiss.) Of Iran, B Peymani-Fard

IGC Proceedings (1977-2023)

This research was conducted on ten ecotypes of red bromegrasses of Iran at Homand Range Experiment Station, near Damavand, Iran to asses: (a) the differences in phenological characteristics, (b) to evaluate differences in herbage yield, and (c) determine the crude protein percentage Parameters measured include duration of vegetative, heading, maturity stages, herbage yields, and crude protein. Variation in vegetative growth, heading and seed maturity stages among the ecotypes under study was very small

Therefore, there are no prefences in selection of a specific ecotype from the standpoint of utilization and harvesting time. There was a great fluctuation in annual herbage …

Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung

Theses and Dissertations

Regulatory toxicology depends primarily on animal testing, which limits throughput, mechanistic interpretability, and applicability to human-relevant endpoints. This dissertation presents computational approaches that integrate publicly available bioactivity data with machine learning to support chemical safety evaluation. Oral carcinogenicity was modeled using curated chemicals from the US Environmental Protection Agency’s Integrated Risk Information System (IRIS) and activity data from over 1,900 PubChem assays. Quantitative structure-activity relationship (QSAR) models trained on statistically prioritized assays demonstrated strong predictive performance and were applied to rank the carcinogenic potential of more than 16,000 compounds. Hepatotoxicity was evaluated using a hybrid modeling approach that combined structural …

Isolation And Importance Of Endophytic Actinomycetes Of Some Red Sea Algae And Their Biological Activities, Najla Ali Alburae

Journal of King Abdulaziz University: Marine Science

Endophytic Actinomycetes attract scientist's attention and in particular, endophytes from marine algae were documented and showed many biological activities that maintain ecological balance in various habitats that solve many health problems. This research aimed at the development of antimicrobial and antioxidant agent from endophytic Actinomycetes. Three seaweed algal samples were collected from the Red Sea Umluj corniche, nestled in northwestern of Saudi Arabia and identified as Ulva lactuca (Chlorophyta), Dictyota dichotoma (Phyaephyta) and Gelidium sp. (Rhodophyta). The collected algal samples were washed, surface sterilized, cut into small squares for Endophytic Actinomycete isolation on Starch nitrate medium containing 10% NaCl. Twelve …

Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin

Faculty, Staff and Student Publications

Background: Body mass index (BMI) has a complex association with a variety of chronic pain conditions, which may be influenced by sleep apnea syndrome (SAS). However, the role of SAS within the causal pathway linking BMI to chronic pain remains unconfirmed. This study explored whether and to what extent SAS serves as a mediator between BMI and chronic pain using Bayesian-weighted Mendelian randomization (BWMR) techniques.

Methods: This study utilized genome-wide association study (GWAS) summary data for BMI (N=461,460) and SAS (N=476,853; based on ICD-10 code diagnostic registries) from the IEU OpenGWAS database, along with chronic pain GWAS data (ICD-10 code-based …

Bite By Bite: How Ungulate Browsing Shapes North America's Forest Future, Darius Hardalau, Vladut Stefanescu, Mindaugas Bakševičius, Michael Manton, Charles Ruffner, Gediminas Brazaitis, Georgeta Ionescu, Ovidiu Ionescu

Aspen Bibliography

Ungulate browsing represents a contemporary issue for forest development, influencing forest regeneration, composition, and management practices across the world, especially in North America. This review synthesizes findings from 101 studies conducted between 1980 and 2025 to examine patterns of herbivory damage through browsing by moose, elk, white-tailed deer, black-tailed deer, and bison. Despite regional variation, high ungulate density consistently emerges as the primary factor driving browsing intensity and ecological and economic impact, leading to decreased social acceptance of coexistence with ungulates. This review highlights the selective suppression of palatable species such as balsam fir, red oak, and white cedar, leading …

On The Possibility Of Predicting The Approximate Fatty Acid Composition Of Blends Based On The Iodine Number, Adiba M. Serkaeva, Akhror A. Abdurakhimov, Nafisa S. Husanova, Kamar P. Serkaev

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the study was to conduct research to determine the possibility of predicting the approximate fatty acid composition of blends based on the iodine number. The fatty acid composition was determined by the chromatographic method and the results were subsequently used to identify the composition of blends by determining the iodine number. The iodine number was determined by calculation and titrimetric methods, comparing the differences between the obtained values. The detected deviations in values between the two methods do not exceed 0.4%, which means that it is possible to predict the approximate fatty acid composition of blends based …

A Battle Of Armies: Massive Attack Of Natural Enemies To The True Armyworm Mythimna Unipuncta (Haworth, 1809) (Lepidoptera: Noctuidae) In Forage Crops, Armando Falcon-Brindis, Raul T. Villanueva

Insecta Mundi

Understanding the interactions between plant-host-parasitoid plays a major role in insect pest management. Farmers in the southeastern United States rely on pasture systems for cattle milk and beef production, but the benefits of parasitoids and predators on major lepidopteran pests on pasture lands are still overlooked. Here, we aimed to identify and quantify the effect of parasitism on the true armyworm Mythimna unipuncta (Haworth, 1809) (Lepidoptera: Noctuidae) attacking teff grass Eragrostis tef (Zucc.) Trotter (Poaceae) and crabgrass Digitaria sanguinalis (L.) Scop. (Poaceae) in western Kentucky. In early August of 2023, 547 larvae of M. unipuncta were collected from experimental …

Living Heritage, Resilience And Ethically Informed Infrastructures In Malawi, Martha B. Lerski, Frank Puluputu Mwale

Publications and Research

Rooted in a rural community’s needs, this paper explores how historically, and ethically informed infrastructures can support community engagement towards identification, documentation, and dissemination of local, traditional, and indigenous knowledge relating to climate change. The paper examines climate adaptation and sustainability issues through the lenses of community organizing and Library & Information Science best practices. It draws on a growing body of literature identifying a role for expanded epistemological and subject discipline perspectives. While the impacts of climate on material culture are increasingly recognized, intangible, and biocultural heritage have not received as much attention. Living heritage traditions and knowledge systems …

Political Agroecology In Syracuse: Local Understandings, Possibilities, And Barriers To Food System Transformation, Cooper Olds

Theses - ALL

In recent years, agroecology has begun to receive increasing attention from international institutions such as the United Nations Food and Agriculture Organization (UN FAO). For some, this is seen as a valuable case of up-scaling agroecology which will lead to greater institutional support for the framework. However, critical agroecologists have raised concerns that such institutional adoption is rather a form of co-optation where the social and political elements of agroecology are omitted to facilitate the integration of the framework into a wider program of food system reform. As a result, there is ongoing contestation over the framework between these co-opted …

Impact Of Oceanographic Gradients And Marine Heatwaves On The Picophytoplankton Community In The Northern California Current System, Kristin E. Forgrave, Carey P. Sweeney, Melissa Steinman, Anvita U. Kerkar, Timothy M. Pettit, Anne W. Thompson

Biology Faculty Publications and Presentations

The Northern California Current (NCC) system is a productive coastal ecosystem with a mosaic of temporal and spatial features. The phytoplankton community plays a crucial role in supporting the rich ecosystem and economically important fisheries of the NCC. Our study integrates data across two years (2022-2023) and multiple transects to investigate the community composition of two major phytoplankton groups in the NCC: picocyanobacteria and photosynthetic picoeukaryotes (PPE). The abundances and cell sizes of the phytoplankton were measured using flow cytometry. We found PPE present at similar concentrations in both summer and winter, while picocyanobacteria were much more abundant in the …

The Effect Of Breakfast On A Resistance Training Session And Response In Female Collegiate Athletes, Haley Roberts, Yvette Figueroa, Jennifer Bunn, Patrick Davis

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 591-609, 2025. Breakfast consumption has been shown to be an essential component to a healthy lifestyle in various populations, yet research in this area is limited among female athletes. This study aimed to examine the effect of breakfast consumption on collegiate female athletes during a resistance training session and their nutritional habits throughout the remainder of the day. Twenty-three female collegiate Division I athletes (basketball, volleyball, bowling, and soccer) during the offseason participated in this cross-over study. The study included three visits: baseline measures for heart rate (HR), blood glucose (BG), salivary cortisol (SC), …

The Growth Of White Clover (Trifolium Repens L.) In Field Swards In Wales. A Review., D Wilman

IGC Proceedings (1977-2023)

The purpose of the paper is to review some studies of white clover (Trifolium repens L.) growth in field swards in Wales, which were supervised by the author in the period 1976-88. White clover is a valuable species, from the point of view of both nitrogen fixation and animal nutrition, but it is used successfully on only a small proportion of farms in the United Kingdom. Studies such as those reviewed should contribute to greater success in white clover use.

Evaluation Of Mixed Pastures Including Trifolium Pratense Under Grazing, L A. Romero

IGC Proceedings (1977-2023)

The feeding system for milk and beef production in the Cen­tral Region of Santa Fe province (Argentine) is based on semi­permanent and seasonal pastures along with conserved forage. Generally, legumes and grasses mixtures are used, the more usual species being lucerne (Medicago sativa), red clover (Tri­folium pratense), prairie grass (Bromus catharticus), and also chicory (Cichorium intibus). These mixtures produce high amount of dry matter (DM) with a high nutritive value and an useful life span of three to five years. The objective of this research was to evaluate three mixed pastures with red clover …

Regrowth Of The Components Of Two Legume/Grass Associations Following Grazing On Acid Soils Of The Eastern Plains Of Colombia, J Fischer, D Thomas

IGC Proceedings (1977-2023)

The low nutritive status of the neotropical savannas may be improved by using a forage legume, either to supplement the savanna, or as a component of a grass-legume pasture to replace it. The two stoloniferous legumes Arachis pintoi and Desmodium ovalifolium form promising associations with various species of Brachiaria (Grof, 1985; Thomas and Grof, 1986), but there are very few data on their reaction to grazing. The relation between growth rate and the amount of leaf material is central to understanding how systems of grazing management influence plant relations. Because the palatability of the two legumes above differ, under contrasting …

Effect Of Regrowth Interval Upon Canopy Structure And Utilization Of Aeschynomene-Limpograss Pastures, J E. Moore, L E. Sollenberger, K A. Albrecht, P T. Beede, W F. Brown

IGC Proceedings (1977-2023)

During mid-summer through early autumn, limpograss ( Hemarthria altissima) herbage may have crude protein con­centration below 7 %, and performance of growing cattle on limpograss pasture is often low (Sollenberger et al., 1988). Overseeding with Aeschynomene americana may improve for­ age intake and nutritive value. Deferred grazing of an aeschynomene-limpograss association has potential to provide high-quality forage into mid-autumn. Because grass and legume do not have similar growth rates, changes in canopy structure may occur during late season which influence forage utilization by grazing cattle. The objective was to compare plant canopy characteristics to diet composition and ingestive behavior of …

Effects Of Variation In Seasonal Grazing Pressure And Mechanisms Of Adaptation To Grazing In Lotononis Bainesii, H Fujita, L R. Humphreys

IGC Proceedings (1977-2023)

Lotononis bainesii is valued for its ready acceptance by stock, high nutritive value and cold tolerance, but its utility has been limited by the inexplicably high year to year variation in its contribution to the farm feed supply. Pott et al. (1983) showed that lotononis is short-lived; the persistence of yield depends more upon seedling regeneration than upon vegetative replace­ment through nodal rooting. No continuous fixed stocking regime from 7 to 28 sheep ha-1 favoured lotononis (Poot and Humphreys, 1983), and this paper discusses the effects of vari­ations in seasonal stocking rate and of factors influencing the development of a …

Dynamics Of A Tropical Grass-Legume Sward In The Subtropics And Its Effect On Animal Performance, M J. Williams, A C. Hammond, W T. Butts, W E. Kunkle

IGC Proceedings (1977-2023)

Rhizoma perennial peanut ( Arachis glabrata Benth.) is a for­age legume species adapted to the well-drained soils of subtropical United States (Prine et al., 1981). Management studies with perennial peanut have concentrated on hay pro­duction and animal performance based on pure stands (Prine, 1981 ; Sollenberger et al., 1987). Mixtures of perennial peanuts and various tropical grasses have performed well in small plot studies, but the interrelationship of grass and perennial peanuts under grazing and the consequence this relationship has on stand productivity and animal performance has not been investigated. The summer grazing phase of a backgrounding systems trial, which …

Hay Quality And Marketing Improved With Wyoming Hay Evaluation And Listing Service, A M. Gray

IGC Proceedings (1977-2023)

Hay production in the United States of America (US) is about 140 million metric tons/year. In 1987 most US hay producers had fewer marketing opportunities because of surplus production and lower demand due to a continuing national decline in livestock numbers. In Wyoming, marketing hay on the basis of forage quality is becoming critical for the economic survival of many hay­growers, particularly in years of low demand for hay. Demand for high quality hay by specialty markets (dairy and horse hay) is greater than supply throughout the US. However, buyers for such markets insist that quality hay is difficult to …

Effects Of Ammoniation Of Rice Straw On Its Feeding Value For Lambs, J Q. Ferreira, R Garcia

IGC Proceedings (1977-2023)

Great quantities of crop residues are produced in Brazil at harvest time. The production of rice straw reachs approxi­mately ten million of tons each year and very small quantity is used for animal feeding. The interest on utilization of rice straw increased in the last years mainly due to possibility of ammonia use for improvement of nutritive value of crop residues (Sund­stol el al., 1978 ; Saenger el al., 1983 ; Herrera-Saldana el al., 1982; Streeter and Horn, 1984; Grotheer el al., 1986; Horton and Steacy, 1979). The objective of this study was to measure the effect to ammoniation on …

Effect Of Ammonia Level, Time Of Exposure To Ammonia And Period Of Storage On Chemical Composition And Digestibility Of Two Tropical Grasses Hay, R A. Reis, R Garcia

IGC Proceedings (1977-2023)

The production of good quality hay in Central Brazil has been limited by the nature of cultivated species and constant presence of rainfalls. However, at the end of summer and part of fall seasons the environmental conditions are adequate for hay making but the forages show lower nutritive value. An alternative to improve the quality of tropical grasses hay would be the use of ammonia. Several studies (Buettner et al., 1982; Grotheer et al., 1986; Brown et al., 1987; Moore and Lechtenberg, 1987), showed decreases in NDF and hemicellulose on forages treated with ammonia. The influence of levels of ammonia …

Haymaking From Tropical Grasses, J L. Costa, J A. Gomide

IGC Proceedings (1977-2023)

Haymaking from pasture growth surplus is an alternative way to provide winter feeding to cattle. Some interest has recently been developed toward making hay from tropical grasses in their vegetative stage. The main hazard with this approach being the occurence of likely rains during field dry­ing. This can be helped by shortening drying time through the use of appropriate harvester (Savoie et al., 1982) as well as selection fo species with higher drying rate (Morris, 1972; Per­son and Sorenson, 1970).

Hayval : A Microcomputer Program For Evlauting The Winter Feeding Needs Of Beef, Sheep, And Horses, D B. Hannaway, S A. Dahl, P J. Ballerstedt, P E. Shuler, W Rogers, F Shafabakhsh, J Smith, M Lawyer

IGC Proceedings (1977-2023)

HA YV AL is a microcomputer programm which was developed to teach concepts of hay quality and animal nutrition. HA YV AL answers the question, 'Will the hay I have available meet the nutritional needs of the animals I am feed­ing ?'. It does so by using an interactive teaching technique ; asking questions about the animals and the hay being fed.

Increasing The Contribution Of Grass Silage For Milk Production, C Thomas, A Reeve

IGC Proceedings (1977-2023)

The conservation of grass as silage rather than hay has become increasingly popular in Northern Europe. The increase in silage making has been associated with the increased intensi­fication of animal production and improvements in our knowl­edge of the fermentation process. Despite the ability to produce grass silages with consistently high metabolisable energy (ME) and crude protein (CP) contents it has been calculated that on UK dairy farms silage barely meets the maintenance require­ment of the cow (Phipps, 1986). The objective of the work reported here is to devise methods to increase the contribution of silage in the diet of the …

Chemical And Nutritive Values Of Three Ensiled Residues (Broad Beans, Peas And Soybean) In Comparison With Yellow Lupin Silage, J Efe Serrano

IGC Proceedings (1977-2023)

The agro-industrial residues of legumes in Portugal has increased recently in animal feeding, but with little information about the nutritive values of these diets. The few values from literature (Economides and Had­jidemetriou, 1974; Boza and Guerreiro, 1981 ; Escandon et al., 1983) or in Tables of Food Composition are quite different. In south of Portugal, the yellow lupin is an expanding forage used in sheep diets as hay or silage. The purpose of this work, and others in progress, was to compare the feeding value of silages made from three important residues with the yellow lupin silage.

Effects Of Wilting And Formic Acid On The Chemical Composition And Nutritive Value Of Elephant Grass Silage Pennisetum Purpureum Schum) Purple Cultivar, W Lavezzo, Otavia E.N.M Lavezzo, C Rossi, I A. Bonassi

IGC Proceedings (1977-2023)

At the beginning of the growth the Elephant grass had a good dry matter production and a good nutritive value and due to this it is often used for ensilage in Brazil. However, when best suited age for ensilage (50-60 days), its water content is high making normally difficult to get suitable silages. Although reasonable silages of Elephant grass have been obtained with no additives (Tosi et al., 1983), the wilting and formic acid utili­zation during the ensilage have resulted in good quality silages (Silveira et al., 1979) with good nutritive value (Lavezzo et al., 1984). The purpose of this …