Digital Commons Network^™

Non-Enzymatic Hepatic Abhd6 Interacts With Akt-Foxo1 Axis To Regulate Metabolic Health, Guannan Li, Laurence T Maeyens, Jiyuan Yin, Jan-Bernd Funcke, Chanmin Joung, Ruizhen Li, Ziying Xu, Ting Wu, Xin Li, Nisi Jiang, Mbolle Ekane, Maria Paula Lopez, Pengju Cao, Sijia He, Adam B Salmon, S R Murthy Madiraju, Marc Prentki, Juli Bai, James F Nelson, Xianlin Han, Yi Zhu, Shangang Zhao

Children’s Nutrition Research Center Staff Publications

The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD), is poorly understood. To define the role of ABHD6 in liver physiology, we generated liver-specific ABHD6 knockout mice, as well as liver-specific native and enzymatically inactive mutant ABHD6 overexpression mouse models. We demonstrate that non-enzymatic ABHD6 contributes to the regulation of selective hepatic insulin resistance and MASLD progression. Mechanistically, we show that ABHD6 localizes to the nucleus and interacts with Akt/FoxO1 axis to regulate insulin …

Thermal Conversion Of Cotton Gin Byproducts Into Liquid Fuels And High-Value Chemicals, Emmanuel Asare

Mechanical Engineering Theses

In this study, we performed fast pyrolysis, catalytic fast pyrolysis (CFP), and catalytic hydropyrolysis (CHP) of cotton gin byproducts (CGB) to investigate their conversion into hydrocarbon-rich liquid fuels and high-value aromatic chemicals. Five CGB fractions (CC1, CC2, SM, TM, and FCGB) were collected from different stages of cotton ginning operation and characterized by proximate, ultimate, and higher heating value (HHV) analysis. The feedstocks contained 41.5 44.8 wt.% carbon, 54.2–58.5 wt.% volatile matter, 6.0–15 wt.% ash, and higher heating values of 15.2–16.8 MJ kg⁻¹. All pyrolysis experiments were performed using a Pyroprobe 5200 coupled with GC-MS/FID, while catalyst loading, hydrogen pressure, …

Harnessing Kenyan Aquaculture Through Social Media: Impacts, Challenges And Strategic Directions, Domitila Kyule, Jonathan Munguti, Mavindu Muthoka, Esther Magondu, Menaga Meenakshisundaram, Chrysantus M. Tanga, Kevin Obiero, Cecilia Githukia

All Peer-Reviewed Publications

Aquaculture is increasingly important for food, nutrition and livelihoods in Kenya, but the sector still faces persistent constraints in extension delivery, farmer learning, input access, market coordination and information reliability. This review examines how social media and related digital communication tools are shaping aquaculture development in Kenya, with attention to impacts, challenges, governance needs and strategic directions. A systematic literature review of studies and institutional sources published between 2015 and 2025 was conducted. The search identified 388 records, of which 45 sources were included in the final synthesis after screening, eligibility assessment and quality appraisal. Because the evidence was heterogeneous, …

Analyses Of Atheroprotective Effects From Mir-33a Deletion In Primary Vascular Smooth Muscle Cells, Achala Pokhrel

All Theses

Atherosclerosis is one of the major causes of cardiovascular disease, characterized by the accumulation of cholesterol and foam cells within the arterial walls. Foam cells were traditionally believed to originate from macrophages; however, recent studies have shown vascular smooth muscle cells are also capable of accumulating cholesterol and developing foam-cell-like characteristics. ATP-binding cassette transporter A1 (ABCA1) plays an important role in removing excess cholesterol from cells by transporting intracellular cholesterol to circulatory apolipoprotein A-I (apoAI). MicroRNA-33a (miR-33a) is known to suppress ABCA1 expression and limit cholesterol efflux. However, its role in primary aortic smooth muscle cells is unknown and not …

Effects Of Beverage Color During Mouth Rinsing On Measures Of Muscular Endurance, Muscular Strength, And Exercise Perceptions During Isometric Handgrip Testing, Sydney Andrews

Exercise Science Theses & Dissertations

Previous research has shown that color can influence psychological responses, physiological responses, and exercise performance. These effects have been previously attributed to learned associations or expectations which may influence exercise-related outcomes. This study aimed to investigate whether beverage color influences muscular performance during intermittent isometric handgrip exercise. This randomized, single-blind, deceptive crossover study consisted of 34 physically active adults (21.9±3.1 years) who completed a handgrip endurance test under three conditions: red beverage rinse, clear beverage rinse, and no-rinse. Participants were informed that the study would examine the effects of mouth rinsing two commercially available carbohydrate containing sport drinks on muscular …

Blue Crab Reproductive Output And Phenology In A Changing Climate, Blaise Rohan

Master's Theses

Globally, ecosystems are experiencing rising temperatures due to climate change, with potential consequences for reproductive investment and timing in many species. Blue crabs, Callinectes sapidus, support valuable commercial fisheries throughout the U.S. Atlantic and Gulf coasts, and understanding variation in reproductive output has important management and conservation implications. This study examined two components of blue crab reproduction: (1) reproductive investment across populations spanning multiple latitudes (New York, New Jersey, North Carolina, Mississippi, and Texas), using a space-for-time substitution to assess the effects of varying thermal regimes on fecundity and egg quality, and (2) spawning phenology in North Carolina from …

Comparison Of Lower-Extremity Coordination Patterns During Countermovement Jumps Between Dancers And Nondancers, Danielle Joseph

Honors Theses

Jumping is a skill essential to several different sports, including dance. For athletes in jump-dominant sports, jump strategies can vary with differences in task demands while jump performances are similar. The countermovement jump (CMJ) has been utilized to analyze jumps because of their reliable indications of power and neuromuscular function. Methods of describing jump strategies using CMJ, such as force plate metrics, vector coding analysis, and coordination phases, have been used to describe the jumps of athletes in jump dominant sports such as basketball and volleyball. However, less jump strategy research has been done on dancers, especially to describe the …

B.R. Wells Arkansas Rice Research Studies 2025, J. Hardke, X. Sha, N. Bateman

Arkansas Agricultural Experiment Station Research Series

Arkansas is the leading rice producer in the United States. The state represents 45.2% of total U.S. rice production and 45.7% of the total acres planted to rice in 2025. Rice cultural practices vary across the state and across the U.S. However, these practices are also dynamic and continue to evolve in response to changing political, environmental, and economic times. This survey was initiated in 2002 to monitor and record changes in the way Arkansas rice producers approach their livelihood. The survey was conducted by polling county extension agents in each of the counties in Arkansas that produce rice. Questions …

Engagement Of Understudied Populations As Community Change: The South Texas Adrc Model, Gladys E. Maestre, Neela K. Patel, Rosa V. Pirela, Robin C. Hilsabeck, Kendra Stine, Neyra García, Roberto Reyes, Omar Oropeza, Cristian Maestre, Jesus D. Melgarejo, Sarah Williams-Blangero, Ney Alliey Rodriguez

School of Medicine Publications

Many populations experiencing the highest burdens of Alzheimer's disease and related dementias remain understudied, in part because traditional recruitment and retention models are insufficient to support sustained engagement. The Outreach, Recruitment, and Engagement Core (OREC) of the South Texas Alzheimer's Disease Research Center reconceptualized participant recruitment as a long-term system change in a Hispanic-majority, urban–rural region. OREC institutionalizes shared power through community advisory governance, aligns research protocols with local lived realities (through patient navigators, community health workers/promotores, and decentralized access points), and employs a data-driven feedback loop for continuous improvement. In 1 year, 46 outreach events touched 10,134 individuals (71% …

Seizure Susceptibility And Morphological Analysis Of A Missense Mutation In Hcfc1a Protein, Jose Manuel Fabela

Open Access Theses & Dissertations

Missense mutations in the HCFC1 gene cause methymalonic acidemia with homocystinuria cblX type (MIM#309541). cblX is an X-linked disorder that is associated with multiple phenotypes such as metabolic defects, failure to thrive, intractable epilepsy, facial dysmorphia, movement disorders, and intellectual disability. The mechanisms underlying these phenotypes are not completely understood. Here we used a zebrafish germline mutant allele (hcfc1aco64/co64) to study seizure susceptibility and adult brain structural malformations. Previous studies have established neural progenitor cell defects and hypoactive mechanistic target of rapamycin (mTOR) in this allele. Given the known role of mTOR in seizure phenotypes, we hypothesized that missense mutation …

The Effect Of Sustainable 3d Store Design On Consumer Online Shopping Behavior, Sophie G. Roussel

Apparel Merchandising and Product Development Undergraduate Honors Theses

Sustainability has become a significant factor in shaping consumer shopping habits. Companies are implementing 3D store designs to provide a more immersive and interactive experience. Further study is needed to investigate whether a sustainable, green-focused 3D storefront shifts consumers’ satisfaction with online shopping and their intention to buy products from a sustainable store. This study seeks to fill the research gap by examining how sustainable 3D store design influences consumer shopping behavior. Specifically, three distinct 3D store mockups were developed using Visual Retailing (VR) technology. The same number of visually appealing features, products, and store layouts was used to make …

Bridging Animal Production And Human Nutrition: How Production Ecology Shapes The Nutritional Quality Of Terrestrial Animal Foods And Human Omega-3 Status, Joseph Vinod Varre

All Graduate Theses and Dissertations, Fall 2023 to Present

The question at the center of this dissertation is simple: does the way food is produced change the quality of the food itself in ways that matter for human health? Across a series of studies on bison meat, eggs, and human dietary intervention, the answer was yes. This work began with a broad look at the modern food system and the nutritional consequences of industrialized diets. In particular, it focused on the growing imbalance between omega-6 and omega-3 fatty acids in the Western diet. This balance matters because omega-3 fats support heart, brain, and immune health, and diets high in …

Divergent Belowground Strategies Of Savanna Grasses Under Varying Fire Regimes, Abigail C. Schmidt

All Graduate Theses and Dissertations, Fall 2023 to Present

Savannas are unique ecosystems, where trees and grasses live together across the landscape, not quite forming full forests or open grasslands. The ability for trees and grass to coexist is largely the result of widespread disturbances, such as fire. Fire in savannas is largely thought of in how it maintains plants above ground, however, fire also plays a key role in ecosystem and plant processes belowground. First, fire can change how soil nutrients, namely phosphorus, are cycled. Phosphorus is a key nutrient that plants need to function, and plants acquire phosphorus through their roots. Frequent fire can enhance phosphorus availability, …

Agronomic And Economic Evaluation Of Alternative Forage Crops Under Irrigation Technologies And Deficit Irrigation, Shikha Sharma

All Graduate Theses and Dissertations, Fall 2023 to Present

Water is becoming more limited in the western United States, including Utah, so farmers need forage crops that can produce well while using less irrigation water. This study examined how different forage crops respond to reduced irrigation and different irrigation application methods, and whether some crops can provide better economic returns under limited water conditions.

Field studies were conducted at three Utah locations, Cedar City, Logan, and Vernal, from 2020 to 2024. The alternative forage crops included teff, sorghum-sudangrass (sudex), and forage rye. For economic comparison, conventional forage crops included alfalfa, corn, and three-way small grains. Four to five irrigation …

Youth Agricultural Engagement And Its Association With Dietary Diversity, Household Food Insecurity, And Nutritional Status In Southwest Nigeria, Sherif Olasoji

All Graduate Theses and Dissertations, Fall 2023 to Present

Youth remain underserved in nutrition research, policy, and programming despite being an integral part of the food systems. While the nutrition-sensitive agriculture framework has been established, there is limited evidence demonstrating how youth engagement in agriculture can serve as a pathway to improve nutritional outcomes. The study assessed youth agricultural engagement and its association with household dietary diversity, household food insecurity, and nutritional status in southwest Nigeria.

Using a cross-sectional design, data on socio-demographic characteristics, agricultural engagement, dietary diversity, household food insecurity, body mass index, and skin carotenoids were collected from 143 youth aged 15 to 35 from Ekiti, Osun, …

Integrating Space Use And Demography To Support Management Of An Endangered Alpine Ungulate, Danielle J. Berger

All Graduate Theses and Dissertations, Fall 2023 to Present

The places animals choose to live affect the food they find, the dangers they face, and the weather conditions they experience. These experiences influence whether individual animals survive and reproduce, which in turn affects the size and health of animal populations. Although scientists have long believed that animal movements play an important role in population trends, there has been limited real-world evidence showing this connection. Advances in GPS tracking technology now allow researchers to follow animals over long periods and better understand how movement influences survival. Using 20 years of GPS tracking data from the endangered Sierra Nevada bighorn sheep …

Incorporation Of Dairy Ingredients Into Chocolate And Caramel: Impact On Product Quality, Shelf Life, And Consumer Acceptance, Taelie Kennedy

All Graduate Theses and Dissertations, Fall 2023 to Present

Incorporating next-generation milk powders like milk protein isolate (MPI) and milk protein concentrate (MPC) into confections can increase protein content. Milk permeate powders (MPP) are byproducts of the production of high-protein dairy ingredients (MPC and MPI). Typically considered waste streams, growing awareness of sustainability has increased interest in the use of MPP in food. There is minimal research on the use of these ingredients in confections. 

This study evaluated the effects of incorporating milk protein powders and MPP into chocolate and the effects of replacing granulated sugar with MPP in caramel on product quality and consumer acceptance. 

Chocolate batches were …

The Effects Of Psychological Stress On Gut Health In Mice Fed Either A Healthy Diet Or The Total Western Diet, David Keenan Thomas Prescott

All Graduate Theses and Dissertations, Fall 2023 to Present

The Total Western Diet (TWD), a rodent diet designed to model the typical American dietary pattern, has been shown to worsen inflammation and colitis severity in mice. Psychological stress has also been associated with increased intestinal inflammation, barrier dysfunction, and alterations to the gut microbiome. The goal of this study was to determine whether combining the TWD with psychological stress would further worsen colitis severity and alter the gut microbiome. To investigate this, mice were fed either a healthy control diet or the TWD and exposed to psychological stress using a social disruption stress model. Colitis was induced using established …

Drought And Diet Breadth: Does Insect Specialization Influence Herbivory When Plants Are Under Stress?, Jakob Palmer

All Graduate Theses and Dissertations, Fall 2023 to Present

Climate change will alter precipitation worldwide, causing more frequent and severe drought events worldwide. Drought affects many ecological processes, including plant-herbivore interactions, which are critical to biodiversity and ecosystem health. A variety of plant characteristics can influence herbivory – such as how hairy, nutritious, or toxic a leaf is – and drought has been shown to alter many of these traits. Unique characteristics of herbivore species are also important: herbivores can either feed on a variety of plants (generalists) or a group of closely related plants (specialists). Specialists can cope with traits of the plants they eat, while generalists are …

Formulation And Analysis Of Physiochemical And Sensory Properties Of Ready-To-Mix Whey Protein Phospholipid Concentrate Beverage, Chris Jaquin

All Graduate Theses and Dissertations, Fall 2023 to Present

Whey protein phospholipid concentrate (WPPC) is commonly recovered as a coproduct in filtration process whose aim is to obtain whey protein isolate (WPI) from whey protein concentrate (WPC). Whey protein phospholipid concentrate is high in milk fat globule membrane (MFGM), which has been shown in rodent and human studies to have a variety of physiological benefits, including an increase in exercise capacity. Whey protein phospholipid concentrate is currently considered as an underused dairy coproduct, with most of it either being disposed of or used as animal feed. This research consisted of incorporating WPPC in a protein shake–like beverage at a …

Microbes In Pollination Systems: Effects On Pollinator Health, Floral Traits, Nectar Robbing, And Plant Fitness, Valerie Nicole Martin

All Graduate Theses and Dissertations, Fall 2023 to Present

Flowers produce nectar to attract pollinators, but nectar is also a habitat for yeasts and bacteria that arrive via pollinators, robbers, and other visitors. These microbes consume nectar sugars and release byproducts that change the smell and taste of nectar. Whether these changes affect how pollinators find and choose flowers, and whether they ultimately affect how many seeds a plant produces, is not well understood. In this dissertation, I studied how a common nectar yeast and a plant-associated bacterium affect the scent of wildflowers, the behavior of bumble bees and hummingbirds, and plant reproduction in montane meadows in central Colorado. …

Effect Of Food Resource, Preservation Method, And Preservation Duration On Larval Size Of Forensically Important Fly Species (Order: Diptera), John Zukowski

Student Theses

Forensic entomology is a vital discipline that can aid in the proceedings of criminal cases. Larval age and development are important aspects to consider when utilizing blow flies (Family: Calliphoridae) for estimates pertaining to the initial time of colonization (TOC), which contributes to postmortem interval (PMI) estimations. Thus, it is important to understand the factors that influence larval size and development, since larval size is commonly used as a proxy for age. Larvae of three species of flies, Lucilia sericata (Meigen), Calliphora vicina (Robineau-Desvoidy), and Phormia regina (Meigen), were reared on five different food resources. Specimens of L. sericata and …

Full-Fat Dairy Milk Vs. Isolated Free Nutrient Blend On Postprandial Protein Metabolism And Inflammatory Markers In Adults With Overweight And Obesity, Takeshi M. Barnes, Zan Zupancic, Max T. Deutz, Andrew T. Askow, Colleen F. Mckenna, Jonathan A. Aguilera, Cassidy T. Tinline-Goodfellow, Alexander V. Ulanov, Jared W. Willard, Daniel W. D. West, Michael De Lisio, Daniel R. Moore, Nicholas A. Burd

Kinesiology & Sport Management Scholarship

Excess adiposity is linked to anabolic resistance by blunting the postprandial myofibrillar protein synthetic response to protein ingestion. Full-fat dairy milk may overcome this resistance via a matrix combining high-quality protein with anti-inflammatory lipids. Therefore, we compared the effects of ingesting full-fat dairy milk versus a non-dairy macronutrient match isolated blend on the regulation of postprandial myofibrillar and mitochondrial protein synthesis rates and markers of systemic (i.e., IL-6 and TNF-α) and muscle-related inflammation (i.e., NF-κB, NLRP3, TLR4, and MyD88). Twenty-two obese and overweight adult males and females (BMI = 31.1 ± 3.7 kg m−2; aged 35.3 ± 13.2 y) were …

Polyphenol Diet And Exercise As Neuroprotection From Effects Of Alzheimer's Disease, Michelle Morgan

Loma Linda University Electronic Theses, Dissertations & Projects

Healthy non-pharmacological lifestyle factors, such as regular physical exercise and a dietary supplementation, have been shown to significantly improve cognitive outcomes over time compared to a more sedentary lifestyle and poor diet. Furthermore, exercise may serve as a potential protective factor in attenuating the effects associated with cognitive decline that are characteristic of neurodegenerative disorders, such as Alzheimer's disease (AD). Further, evidence indicates that certain diet interventions can also attenuate the effects of neurodegeneration and positively impact longevity. Supplementation of polyphenols, such as ellagic acid (EA), which are abundant in pomegranate juice, may help provide neuroprotective benefits and elicit a …

Land Condition Standards For The Western Australian Nullarbor Pastoral Region, Peter-Jon A. Waddell, Wayne J. Fletcher

Natural resources published reports

This report outlines the quantitative land condition standards that define acceptable pastoral land condition for the Western Australian part of the Nullarbor, to meet the regulatory requirements of the Land Administration Act 1997 and the Soil and Land Conservation Act 1945.

The Department of Primary Industries and Regional Development is developing regional-level pastoral land condition standards for Western Australia as a critical component of the Framework for sustainable pastoral management – revised edition (Fletcher 2022), the purpose of which is to address the Office of the Auditor General’s recommendations to improve the management of pastoral lands in WA …

Evaluating The Motivations Of Participants In Online Equine Extension Courses, Sarah Vos

Department of Animal Science: Dissertations, Theses, and Student Research

Traditional program evaluations emphasize participant demographics, knowledge gain, behavior change, and program impact. However, evaluating participant motivation can provide addition insight into why participants enroll in extension programs and help explain participant engagement and persistence throughout a program. The purpose of this study was to evaluate participant motivation in two online equine extension courses and examine potential relationships between motivation, demographics, and course delivery method, and describe participant engagement in Virtual Horse Judging Camp (VHJC). This cross-sectional study utilized convenience sampling of participants in two online equine extension courses, Horse Adult Leader Training and Educational Resource (HALTER) and VHJC. The …

Pre-Post Changes In Physiological, Cognitive, And Motivational Outcomes Following An Active Video Game Intervention In Adolescents And Adults: A Pilot Study, Ashley Williams, Danielle D. Wadsworth, Thaangiah Geetha

Publications

Active video games (AVG) are emerging as a promising home-based strategy to increase physical activity by integrating movement into interactive gameplay. However, evidence remains limited regarding their effectiveness across physiological, cognitive, and motivational outcomes in adolescents and adults within household settings.

Flexible Grazing: Evaluating Stocker Cattle As A Drought Management Tool For Utah Livestock Producers?, Ross Israelsen

All Graduate Reports and Creative Projects, Fall 2023 to Present

Drought is a persistent concern in the western United States, often leading to reduced forage production, overgrazing, and economic challenges for livestock producers. This study evaluates the economic feasibility of incorporating stocker cattle as a flexible drought management strategy under varying forage conditions across four Utah grazing locations: Park Valley, Nephi, Vernal, and Beaver. The Rangeland Analysis Platform (RAP) was used to estimate annual forage production and stocking rates from 2001 through 2025. Four stocking-rate scenarios (100%, 75%, 60%, and 50% cow–calf stocking rates) were evaluated using a Net Present Value (NPV) framework to compare the economic performance of traditional …

Hyperadhesive Von Willebrand Factor Contributes To Pathogenesis Of Preeclampsia, Yajuan Wang, Chenyu Wang, Katie L Houck, Xiaoli Gao, Yuanyuan Chen, Xin Xu, Xue Zhao, Miguel A Cruz, Shu Zhang, Chester Q Li, Fengxia Xue, Min Li, Swati Shree, Jing-Fei Dong, Cha Han

Children’s Nutrition Research Center Staff Publications

Background: Preeclampsia is the most common complication of pregnancy, significantly affecting maternal and fetal health, and is characterized by placental and systemic endotheliopathy. Patients with preeclampsia have elevated levels of VWF (von Willebrand Factor), which is associated with poor clinical outcomes. However, whether VWF serves as a marker for endotheliopathy or contributes to the pathogenesis of preeclampsia remains poorly understood.

Methods: We investigated the role of hyperadhesive VWF in the development of preeclampsia by studying patients, evaluating mouse models, and performing in vitro experiments.

Results: We show that patients develop VWF- and fibrin-rich thrombosis in the placenta and have significantly …

Concerns With The Statistical Analysis In “Effect Of Combined Glp-1 Analogue And Bupropion/Naltrexone On Weight Loss: A Retrospective Cohort Study”, Thirupathi Reddy Mokalla, Henry T Robertson, Sherri Pals, David B Allison

Children’s Nutrition Research Center Staff Publications

No abstract provided.