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Hubungan Ketersediaan Fasilitas Jamban Sehat Di Rumah Tangga Terhadap Kejadian Diare Pada Balita Menurut Analisis Data Sdki Tahun 2017 Di Wilayah Pedesaan Papua, Edgina Dhafia Callista, Arina Qonita, Bonyca Verlina, Pratiwi Pamarta Endah Jatmika Jun 2025

Hubungan Ketersediaan Fasilitas Jamban Sehat Di Rumah Tangga Terhadap Kejadian Diare Pada Balita Menurut Analisis Data Sdki Tahun 2017 Di Wilayah Pedesaan Papua, Edgina Dhafia Callista, Arina Qonita, Bonyca Verlina, Pratiwi Pamarta Endah Jatmika

Jurnal Nasional Kesehatan Lingkungan Global

Diarrhea is a disease that commonly affects toddlers and is one of the top causes of death among children aged 1–59 months. In pedesaan areas, diarrhea remains a serious public health issue, with recorded cases reaching as high as 17,811. Purpose of this study is to explore the relationship between the availability of healthy toilet facilities in households and the incidence of diarrhea among toddlers. The research used a cross-sectional study design, utilizing secondary data obtained from the 2017 Indonesian Demographic and Health Survey (SDKI). A total of 222 samples that met the predetermined inclusion criteria were selected through random …


From Differentiation To Disease: Cyclin C Directly Coordinates Transcription And Mitochondrial Dynamics, Alicia Campbell Jun 2025

From Differentiation To Disease: Cyclin C Directly Coordinates Transcription And Mitochondrial Dynamics, Alicia Campbell

Theses and Dissertations

Organelle crosstalk is essential for coordinating cellular responses to various external cues, including stress and differentiation. Two key organelles, the nucleus and mitochondria, engage in extensive crosstalk to manage responses to a range of environmental and developmental signals. Complex processes such as stem cell differentiation and neuronal development rely on organelle crosstalk. Both processes integrate changes in gene expression with cytosolic and organellar remodeling. However, it remains unclear how these two complex processes are coordinated to achieve the desired outcome. This project concentrates on cyclin C (CCNC), a component of the Mediator Kinase Module (MKM), and its role in directly …


Ethnoscience-Based Science Learning Through Composite Board Making Utilizing Eggshell Waste And Water Hyacinth Fiber (Eichornia Crassipes), Asep Khaidir Arpan, Yulia Sukmawardani, Pina Pitriana, Ade Yeti Nuryantini Jun 2025

Ethnoscience-Based Science Learning Through Composite Board Making Utilizing Eggshell Waste And Water Hyacinth Fiber (Eichornia Crassipes), Asep Khaidir Arpan, Yulia Sukmawardani, Pina Pitriana, Ade Yeti Nuryantini

Jurnal Pendidikan Sains

The demand for boards continues to increase every year, while overexploitation of wood leads to environmental degradation and forest loss. On the other hand, eggshell and water hyacinth waste continues to grow without optimal utilization. This research aims to make composite boards based on eggshell waste and water hyacinth fibers and analyze the potential of ethnoscience in science learning. This research used a qualitative descriptive method with a literature and documentation study approach. The materials used in this experiment are eggshell waste, water hyacinth fiber, and polyester resin. The composite board was made by mixing water hyacinth fiber and eggshell …


Teaching Materials Containing Kse To Support Character Education In Mathematics Subjects In Elementary Schools, Kunaenah Kunaenah, Rasiman Rasiman, Bagus Ardi Saputro Jun 2025

Teaching Materials Containing Kse To Support Character Education In Mathematics Subjects In Elementary Schools, Kunaenah Kunaenah, Rasiman Rasiman, Bagus Ardi Saputro

Jurnal Pendidikan Sains

The purpose of the study was to determine the validity, practicality, and effectiveness of teaching materials containing KSE to support character education in mathematics lesson content. This study employs a development research approach based on Borg and Gall's research design. The subjects of the study were in class V at public elementary school Kaliboyo. The data collection instruments used were validity sheets, response questionnaires, validation sheets, and observation sheets. The findings show that experts carried out the validity test, achieving a value of 93.30% in the very valid category. The practicality test results were derived from various sources: students' questionnaires, …


Analysis Of Misconceptions In Learning Biology Mutation Material At High School, Fitri Hayati Kurnia, Tri Wahyu Agustina, Wahyuni Handayani Jun 2025

Analysis Of Misconceptions In Learning Biology Mutation Material At High School, Fitri Hayati Kurnia, Tri Wahyu Agustina, Wahyuni Handayani

Jurnal Pendidikan Sains

This research aims to analyze student misconceptions regarding mutation material in class XII. The research method uses a descriptive approach with mixed methods, which combines qualitative and quantitative methods. Qualitative data was obtained through interviews with biology teachers, while quantitative data was obtained through questionnaires and essay tests on students. The research results indicate that the material that students like is growth and development, while the material they don't like is gene mutation and genetic material. Students' misconceptions occur due to preconception aspects, associative thinking, and a lack of understanding of genetic concepts. It was found that students' understanding of …


Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung Jun 2025

Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung

Theses and Dissertations

Regulatory toxicology depends primarily on animal testing, which limits throughput, mechanistic interpretability, and applicability to human-relevant endpoints. This dissertation presents computational approaches that integrate publicly available bioactivity data with machine learning to support chemical safety evaluation. Oral carcinogenicity was modeled using curated chemicals from the US Environmental Protection Agency’s Integrated Risk Information System (IRIS) and activity data from over 1,900 PubChem assays. Quantitative structure-activity relationship (QSAR) models trained on statistically prioritized assays demonstrated strong predictive performance and were applied to rank the carcinogenic potential of more than 16,000 compounds. Hepatotoxicity was evaluated using a hybrid modeling approach that combined structural …


Antibiofilm Activity Of Amylases Isolated From The Bacteria Associated With The Soft Coral Sarcophyton Trocheliophorum, Asmaa Marshoud Al Harbi, Mamdoh T Jamal, Sathianeson Satheesh Jun 2025

Antibiofilm Activity Of Amylases Isolated From The Bacteria Associated With The Soft Coral Sarcophyton Trocheliophorum, Asmaa Marshoud Al Harbi, Mamdoh T Jamal, Sathianeson Satheesh

Journal of King Abdulaziz University: Marine Science

Amylases are one of the important enzymes with tremendous biotechnological applications. In this study, the amylase enzyme producing bacterial strains associated with the soft coral Sarcophyton trocheliophorum was isolated and identified. The amylases were produced in a specific growth medium and the stability was tested under different pH and temperature conditions. The crude amylases were tested for the antibiofilm activity against two biofilm-forming bacterial strains. The amylase enzyme extracted from two bacterial strains (KAU-AS1 and KAU-AS3) showed good activity in the antibiofilm activity assays. The amylases reduced the growth and attachment of the biofilm bacteria. Also, the amylase enzymes degraded …


Isolation And Importance Of Endophytic Actinomycetes Of Some Red Sea Algae And Their Biological Activities, Najla Ali Alburae Jun 2025

Isolation And Importance Of Endophytic Actinomycetes Of Some Red Sea Algae And Their Biological Activities, Najla Ali Alburae

Journal of King Abdulaziz University: Marine Science

Endophytic Actinomycetes attract scientist's attention and in particular, endophytes from marine algae were documented and showed many biological activities that maintain ecological balance in various habitats that solve many health problems. This research aimed at the development of antimicrobial and antioxidant agent from endophytic Actinomycetes. Three seaweed algal samples were collected from the Red Sea Umluj corniche, nestled in northwestern of Saudi Arabia and identified as Ulva lactuca (Chlorophyta), Dictyota dichotoma (Phyaephyta) and Gelidium sp. (Rhodophyta). The collected algal samples were washed, surface sterilized, cut into small squares for Endophytic Actinomycete isolation on Starch nitrate medium containing 10% NaCl. Twelve …


Accumulation And Distribution Of Microplastic Particles In Recent Coastal Sediments From Specific Areas Of The Syrian Coast And Determination Of Medium Energy, Samer Ghadeer, Yousef Rslan Jun 2025

Accumulation And Distribution Of Microplastic Particles In Recent Coastal Sediments From Specific Areas Of The Syrian Coast And Determination Of Medium Energy, Samer Ghadeer, Yousef Rslan

Journal of King Abdulaziz University: Marine Science

Despite the numerous benefits plastics have brought to our daily lives, they have also introduced many unexpected and serious environmental challenges, particularly for marine environments, their ecosystems, and sediments. This research holds significant importance as it addresses microplastic pollution, a pressing contemporary issue that demands solutions. It marks the first study of its kind on the Syrian coast, utilizing sediments to identify and quantify microplastics, as well as to determine their sizes and the primary human activities contributing to their spread. A comprehensive study was conducted on sediment samples from specific areas along the Syrian coast-Wadi Qandel, Banias, and Al-Mantar-to …


Metabolic And Physiological Regulation In C. Elegans: Insights Into Sperm Activation And Peroxisome-Mediated Longevity, Yash Flora Jun 2025

Metabolic And Physiological Regulation In C. Elegans: Insights Into Sperm Activation And Peroxisome-Mediated Longevity, Yash Flora

LSU Doctoral Dissertations

Organelle dynamics lie at the heart of cellular signaling and metabolic regulation, orchestrating physiological processes such as reproduction and aging across the lifespan. In this dissertation, I investigate how organelle-based signaling coordinates sperm activation and modulates organismal aging in the nematode Caenorhabditis elegans. I identify SPIN-4, a previously uncharacterized Spinster family transporter, as a key regulator of spermiogenesis. SPIN-4 is strongly expressed in developing sperm, localizes to the plasma membrane, and promotes sperm activation by facilitating the export of sphingosine-1-phosphate (S1P). Loss of spin-4 results in defective pseudopod formation, reduced motility, and compromised fertility, phenotypes that can be rescued …


Knowledge Of Hiv Transmission And Prevention Among University Students In Pakistan: A Cross-Sectional Study, Muhammad Saleem, Sajid Masood, Shahid Hussain Jun 2025

Knowledge Of Hiv Transmission And Prevention Among University Students In Pakistan: A Cross-Sectional Study, Muhammad Saleem, Sajid Masood, Shahid Hussain

Journal of Bioresource Management

HIV/AIDS remains a significant public health problem internationally, with young adults being especially at risk because of behavioral and knowledge deficits. In Pakistan, cultural inhibitions and suboptimal health education are the main reasons for limited awareness, particularly among university students. This study had the objectives of determining the knowledge level about HIV transmission and prevention among undergraduate students in Kohsar University Murree (KUM) and to investigate correlations with salient demographic variables. A cross-sectional survey was carried out among 510 students aged 18-27 years through a pre-validated, standardized questionnaire with 12 knowledge-based items. Descriptive statistics and Chi-square tests were utilized to …


Effect Of Mercury Dose Variation On Growth And Nitrate Reductase Activity In Aquarius Palifolius (Nees & Mart.) Christenh. & Byng, Tsurayya Nurhanifah, Dwi Umi Siswanti Jun 2025

Effect Of Mercury Dose Variation On Growth And Nitrate Reductase Activity In Aquarius Palifolius (Nees & Mart.) Christenh. & Byng, Tsurayya Nurhanifah, Dwi Umi Siswanti

Makara Journal of Science

Mercury, a byproduct of mining, can harm the environment. One method to reduce this impact is through phytoremediation. This study used the Mexican sword (Aquarius palifolius), a plant with the potential to absorb and accumulate mercury. The aim of this study was to examine the effect of mercury stress on nitrate reductase activity, which plays a role in plant productivity, and to assess its impact on growth parameters, including plant height growth rate, leaf length, and number of leaves. Three-month-old A. palifolius plants obtained from rice fields in Sleman were treated with mercury at doses of 0, 14, …


Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin Jun 2025

Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin

Faculty, Staff and Student Publications

Background: Body mass index (BMI) has a complex association with a variety of chronic pain conditions, which may be influenced by sleep apnea syndrome (SAS). However, the role of SAS within the causal pathway linking BMI to chronic pain remains unconfirmed. This study explored whether and to what extent SAS serves as a mediator between BMI and chronic pain using Bayesian-weighted Mendelian randomization (BWMR) techniques.

Methods: This study utilized genome-wide association study (GWAS) summary data for BMI (N=461,460) and SAS (N=476,853; based on ICD-10 code diagnostic registries) from the IEU OpenGWAS database, along with chronic pain GWAS data (ICD-10 code-based …


Phase Ii Basket Trial Of Dual Anti-Ctla-4 And Anti-Pd-1 Blockade In Rare Tumors (Dart) Swog S1609: Pancreatic Neuroendocrine Neoplasm (Pnen) Cohort, Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Bhavana Konda, Mark Walshauser, Edwin Parra, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T Maecker, Ignacio I Wistuba, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Christine M Magner, Helen X Chen, Elad Sharon, Megan Othus, Christopher W Ryan, Charles Blanke, Cara L Haymaker, Razelle Kurzrock Jun 2025

Phase Ii Basket Trial Of Dual Anti-Ctla-4 And Anti-Pd-1 Blockade In Rare Tumors (Dart) Swog S1609: Pancreatic Neuroendocrine Neoplasm (Pnen) Cohort, Sandip Pravin Patel, Jillian Fisher, Young Kwang Chae, Luisa Solis Soto, Anup Kasi, Bhavana Konda, Mark Walshauser, Edwin Parra, Jiexin Zhang, Caroline Duault, Edgar Gonzalez-Kozlova, Ganiraju Manyam, Jianhua Zhang, Hong Chen, Dzifa Yawa Duose, Caddie Laberiano Fernandez, Raja Luthra, Gheath Al-Atrash, Seunghee Kim-Schulze, Holden T Maecker, Ignacio I Wistuba, Sacha Gnjatic, J Jack Lee, Jianjun Zhang, Christine M Magner, Helen X Chen, Elad Sharon, Megan Othus, Christopher W Ryan, Charles Blanke, Cara L Haymaker, Razelle Kurzrock

Faculty, Staff and Student Publications

Purpose: SWOG S1609 Dual Anti-CTLA-4 and anti-PD-1 blockade in Rare Tumors (DART) studied the efficacy of ipilimumab combined with nivolumab across multiple rare tumor types. We report the results of the pancreatic neuroendocrine neoplasm (PNEN) cohort.

Experimental design: Treatment consisted of ipilimumab 1 mg/kg intravenously every 6 weeks with nivolumab 240 mg intravenously every 2 weeks. The primary endpoint was overall response rate (ORR) (Response Evaluation Criteria In Solid TumorsRECIST V.1.1). Secondary endpoints include progression-free survival (PFS), overall survival (OS), and toxicity. Clinical benefit rate (includes ORR plus stable disease (SD)>6 months was examined. Correlative …


A Demand Systems Analysis Of Energy Sources In The United States, Rafael Bakhtavoryan Jun 2025

A Demand Systems Analysis Of Energy Sources In The United States, Rafael Bakhtavoryan

Faculty Publications

This study estimates a Generalized Exact Affine Stone Index model to quantify demand structure among such energy sources as natural gas, coal, nuclear, wind, solar, and geothermal energy, employing monthly time-series data ranging from January of 2009 through December of 2020. The demand for natural gas, coal, and nuclear energy emerges as inelastic. A significant substitutability relationship is empirically established between the energy sources. All the computed expenditure elasticities are positive, with natural gas being the most sensitive and nuclear energy being the least sensitive to energy source expenditures. Pre-committed consumption is found for geothermal energy. Finally, the welfare implications …


Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly Jun 2025

Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly

Karbala International Journal of Modern Science

Background: Vitamin D3  over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia  resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.

Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …


Ifi16 Mediates Deacetylation Of Kshv Chromatin Via Interaction With Nurd And Sin3a Co-Repressor Complexes, Anandita Ghosh, Bala Chandran, Arunava Roy Jun 2025

Ifi16 Mediates Deacetylation Of Kshv Chromatin Via Interaction With Nurd And Sin3a Co-Repressor Complexes, Anandita Ghosh, Bala Chandran, Arunava Roy

School of Medicine Faculty Publications

IFI16 is a well-characterized nuclear innate immune DNA sensor that detects foreign dsDNA, including herpesviral genomes, to activate the inflammasome and interferon pathways. Beyond immune signaling, IFI16 also functions as an antiviral restriction factor, promoting the silencing of invading viral genes through transcriptional and epigenetic mechanisms. We recently demonstrated another role of IFI16, in which it interacts with and recruits the class I histone deacetylases, HDAC1 and 2, to the KSHV latency protein LANA, modulating its acetylation and function. In this study, we asked whether these IFI16-HDAC1/2 interactions contribute to broader epigenetic regulation of the KSHV chromatin. Our findings reveal …


Beyond Silence: A Review- Exploring Sensory Intelligence, Perception And Adaptive Behaviour In Plants, Taranisen Panda, Nirlipta Mishra, Shaik Rahimuddin, Bikram Pradhan, Rajballav Mohanty Jun 2025

Beyond Silence: A Review- Exploring Sensory Intelligence, Perception And Adaptive Behaviour In Plants, Taranisen Panda, Nirlipta Mishra, Shaik Rahimuddin, Bikram Pradhan, Rajballav Mohanty

Journal of Bioresource Management

Plants, traditionally viewed as passive organisms, exhibit sensory and adaptive abilities that challenge conventional notions of plant biology. All organisms evolve ways to sense and interact with their surroundings, and plants, although lacking eyes, ears, or brains, perceive the world in sophisticated ways. Despite lacking a nervous system and other features typically associated with animals, plants can see, smell, hear, feel, learn, remember, and act similarly to animals. This review examines how plants perceive and respond to their environment using mechanisms analogous to vision, hearing, smell, taste, and touch, adjusting their morphology, physiology, and phenotype accordingly. Drawing from plant physiology, …


On The Possibility Of Predicting The Approximate Fatty Acid Composition Of Blends Based On The Iodine Number, Adiba M. Serkaeva, Akhror A. Abdurakhimov, Nafisa S. Husanova, Kamar P. Serkaev Jun 2025

On The Possibility Of Predicting The Approximate Fatty Acid Composition Of Blends Based On The Iodine Number, Adiba M. Serkaeva, Akhror A. Abdurakhimov, Nafisa S. Husanova, Kamar P. Serkaev

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the study was to conduct research to determine the possibility of predicting the approximate fatty acid composition of blends based on the iodine number. The fatty acid composition was determined by the chromatographic method and the results were subsequently used to identify the composition of blends by determining the iodine number. The iodine number was determined by calculation and titrimetric methods, comparing the differences between the obtained values. The detected deviations in values between the two methods do not exceed 0.4%, which means that it is possible to predict the approximate fatty acid composition of blends based …


Digital Infrastructure For The Regenerative Movement: A Case Study Of The Mycelium Learning Network, Abigail Karparis Jun 2025

Digital Infrastructure For The Regenerative Movement: A Case Study Of The Mycelium Learning Network, Abigail Karparis

Journal of Nonprofit Innovation

The regenerative movement is gaining momentum worldwide, driven by communities working to restore ecological and social systems through place-based, culturally rooted action. Yet many of the groups leading this work, especially in the Global South or in hyper-local contexts, remain digitally invisible due to structural barriers, including limited access to appropriate technology, funding constraints, and misalignment between available tools and local values. Conventional digital infrastructures often exclude or marginalize these efforts, leaving regenerative practitioners disconnected from each other and from potential sources of support.

This article explores these challenges and presents a case study response: the co-creation of accessible, relational …


Impact Of Oceanographic Gradients And Marine Heatwaves On The Picophytoplankton Community In The Northern California Current System, Kristin E. Forgrave, Carey P. Sweeney, Melissa Steinman, Anvita U. Kerkar, Timothy M. Pettit, Anne W. Thompson Jun 2025

Impact Of Oceanographic Gradients And Marine Heatwaves On The Picophytoplankton Community In The Northern California Current System, Kristin E. Forgrave, Carey P. Sweeney, Melissa Steinman, Anvita U. Kerkar, Timothy M. Pettit, Anne W. Thompson

Biology Faculty Publications and Presentations

The Northern California Current (NCC) system is a productive coastal ecosystem with a mosaic of temporal and spatial features. The phytoplankton community plays a crucial role in supporting the rich ecosystem and economically important fisheries of the NCC. Our study integrates data across two years (2022-2023) and multiple transects to investigate the community composition of two major phytoplankton groups in the NCC: picocyanobacteria and photosynthetic picoeukaryotes (PPE). The abundances and cell sizes of the phytoplankton were measured using flow cytometry. We found PPE present at similar concentrations in both summer and winter, while picocyanobacteria were much more abundant in the …


Letter Of Concern From The Association Of Academic Chairs Of Emergency Medicine Regarding Acgme Proposed Changes, Richard J Hamilton, Lance B Becker, Richard E Wolfe, D Adam Algren, Thomas Arnold, Michael Baumann, Ross P Berkeley, Terrell S Caffery, Chad M Cannon, Theodore J Corbin, Michael E Chansky, Harinder S Dhindsa, Charles L Emerman, David A Farcy, Chris Fox, Michael A Gibbs, Christopher S Goode, Steven Andy Godwin, Dietrich Jehle, David Johnson, Samuel M Keim, Babak Khazaeni, Barry J Knapp, Clint Hawthorne, John D Hoyle, Michael Christopher Kurz, Evan Leibner, Robert Mcnamara, Robert F Mccormack, Edward A Michelson, Chadwick Miller, Ashley Norse, Andrew Nugent, Brian J O'Neil, David T Overton, Edward A Panacek, William F Paolo, Denis R Pauzé, Amanda L Perez, Ralph J Riviello, Scott W Rodi, Peter S Pang, Juan A Gonzalez Sanchez, David Seaberg, Adam Schwartz, Stephen A Shiver, David P Sklar, Ben C Smith, Jeffrey R Stowell, Marc D Squillante, J Jeremy Thomas, Terry Vanden Hoek, Gregory A Volturo, E Lea Walters, Thomas E Wyatt, Donald M Yealy Jun 2025

Letter Of Concern From The Association Of Academic Chairs Of Emergency Medicine Regarding Acgme Proposed Changes, Richard J Hamilton, Lance B Becker, Richard E Wolfe, D Adam Algren, Thomas Arnold, Michael Baumann, Ross P Berkeley, Terrell S Caffery, Chad M Cannon, Theodore J Corbin, Michael E Chansky, Harinder S Dhindsa, Charles L Emerman, David A Farcy, Chris Fox, Michael A Gibbs, Christopher S Goode, Steven Andy Godwin, Dietrich Jehle, David Johnson, Samuel M Keim, Babak Khazaeni, Barry J Knapp, Clint Hawthorne, John D Hoyle, Michael Christopher Kurz, Evan Leibner, Robert Mcnamara, Robert F Mccormack, Edward A Michelson, Chadwick Miller, Ashley Norse, Andrew Nugent, Brian J O'Neil, David T Overton, Edward A Panacek, William F Paolo, Denis R Pauzé, Amanda L Perez, Ralph J Riviello, Scott W Rodi, Peter S Pang, Juan A Gonzalez Sanchez, David Seaberg, Adam Schwartz, Stephen A Shiver, David P Sklar, Ben C Smith, Jeffrey R Stowell, Marc D Squillante, J Jeremy Thomas, Terry Vanden Hoek, Gregory A Volturo, E Lea Walters, Thomas E Wyatt, Donald M Yealy

Faculty, Staff and Student Publications

This letter, signed by over 50 academic chairs of emergency medicine, urges the ACGME to reconsider a proposed mandate requiring all emergency medicine residency programs to adopt a four-year training model. The authors argue that current three-year programs are supported by data demonstrating equivalent educational and clinical outcomes compared to four-year formats. They criticize the flawed survey methodology underpinning the proposal, note the loss of milestone-based training flexibility, and highlight the lack of added scholarly or clinical value in the fourth year. The letter also outlines negative consequences for fellowship participation, workforce development, trainee debt, and diversity. The signatories advocate …


An Fgfr-P53 Developmental Signaling Axis Drives Salivary Cancer Progression, Julia M. R. Billington Jun 2025

An Fgfr-P53 Developmental Signaling Axis Drives Salivary Cancer Progression, Julia M. R. Billington

USF Tampa Graduate Theses and Dissertations

Mucoepidermoid carcinoma (MEC) is the most frequently occurring salivary gland malignancy.Here, we investigated transcriptomic profiles of human fetal and adult salivary glands and MEC tumors to assess programs involved in MEC progression. Molecular and genetic analyses revealed that MEC tumors and fetal salivary glands share proliferative and developmental gene expression profiles that implicate an FGFR-p53 signaling axis in salivary MEC progression. Based on these findings, we developed a genetically engineered mouse model of advanced MEC via targeted expression of the CRTC1-MAML2 oncogene in salivary ductal cells. Specifically, CRTC1- MAML2 expression combined with p53 dysregulation in salivary ducts rewires FGF signaling …


Daily Movement Activities Are Associated With Within-Person Instability Of Cognitive Function In Older Adults: Evidence From An Ambulatory Assessment Study, Chih-Hsiang Yang, Donald Hedeker, Jongwon Lee, Halle Prine, Donna Coffman, Jingkai Wei, Jonathan George Hakun Jun 2025

Daily Movement Activities Are Associated With Within-Person Instability Of Cognitive Function In Older Adults: Evidence From An Ambulatory Assessment Study, Chih-Hsiang Yang, Donald Hedeker, Jongwon Lee, Halle Prine, Donna Coffman, Jingkai Wei, Jonathan George Hakun

Faculty Publications

Background and Objectives

Physical inactivity and excessive sedentary time (ST) are associated with poor cognitive health in older adults. However, current literature largely relies on cross-sectional designs or in-lab cognitive assessments, which do not adequately reflect cognitive function in naturalistic settings. Further, existing studies have largely overlooked the variability or the instability in daily cognitive function, which represents a critical marker of cognitive decline. This ambulatory assessment study examined the temporal associations of daily movement behaviors with the mean levels and the variability of cognition among older adults at risk of dementia. Research Design and Methods

96 older adults from …


Incidental Findings In Female Pelvis Mri Performed For Gynaecological Malignancies, Silvia Bottazzi, Roberta V Ninkova, Luca Russo, Andrea Ponsiglione, Benedetta Gui, Daniela Demundo, Massimo Imbriaco, Aradhana M Venkatesan, Evis Sala, Stephanie Nougaret, Lucia Manganaro, Stefania Rizzo Jun 2025

Incidental Findings In Female Pelvis Mri Performed For Gynaecological Malignancies, Silvia Bottazzi, Roberta V Ninkova, Luca Russo, Andrea Ponsiglione, Benedetta Gui, Daniela Demundo, Massimo Imbriaco, Aradhana M Venkatesan, Evis Sala, Stephanie Nougaret, Lucia Manganaro, Stefania Rizzo

Faculty, Staff and Student Publications

Incidental findings on female pelvic MRI present diagnostic challenges and may have significant clinical implications. Defined as abnormalities unrelated to the primary imaging indication, these findings have become increasingly prevalent with the expanded use of MRI in gynaecological practice. Standard gynaecological MRI protocols, incorporating T1- and T2-weighted sequences, diffusion-weighted imaging, and contrast-enhanced sequences, facilitate the characterisation of numerous extra-gynaecological abnormalities, ranging from benign to critical lesions. This review proposes a compartment-based approach for identifying extra-gynaecological findings, discussing their imaging characteristics and differential diagnoses. This approach may help radiologists systematically assess incidental findings, potentially improving the recognition of clinically relevant abnormalities …


Living Heritage, Resilience And Ethically Informed Infrastructures In Malawi, Martha B. Lerski, Frank Puluputu Mwale Jun 2025

Living Heritage, Resilience And Ethically Informed Infrastructures In Malawi, Martha B. Lerski, Frank Puluputu Mwale

Publications and Research

Rooted in a rural community’s needs, this paper explores how historically, and ethically informed infrastructures can support community engagement towards identification, documentation, and dissemination of local, traditional, and indigenous knowledge relating to climate change. The paper examines climate adaptation and sustainability issues through the lenses of community organizing and Library & Information Science best practices. It draws on a growing body of literature identifying a role for expanded epistemological and subject discipline perspectives. While the impacts of climate on material culture are increasingly recognized, intangible, and biocultural heritage have not received as much attention. Living heritage traditions and knowledge systems …


A Battle Of Armies: Massive Attack Of Natural Enemies To The True Armyworm Mythimna Unipuncta (Haworth, 1809) (Lepidoptera: Noctuidae) In Forage Crops, Armando Falcon-Brindis, Raul T. Villanueva Jun 2025

A Battle Of Armies: Massive Attack Of Natural Enemies To The True Armyworm Mythimna Unipuncta (Haworth, 1809) (Lepidoptera: Noctuidae) In Forage Crops, Armando Falcon-Brindis, Raul T. Villanueva

Insecta Mundi

Understanding the interactions between plant-host-parasitoid plays a major role in insect pest management. Farmers in the southeastern United States rely on pasture systems for cattle milk and beef production, but the benefits of parasitoids and predators on major lepidopteran pests on pasture lands are still overlooked. Here, we aimed to identify and quantify the effect of parasitism on the true armyworm Mythimna unipuncta (Haworth, 1809) (Lepidoptera: Noctuidae) attacking teff grass Eragrostis tef (Zucc.) Trotter (Poaceae) and crabgrass Digitaria sanguinalis (L.) Scop. (Poaceae) in western Kentucky. In early August of 2023, 547 larvae of M. unipuncta were collected from experimental …


In Memoriam: Donald B. Thomas, Jr., January 26, 1949–November 10, 2024, Brett C. Ratcliffe, Joseph E. Eger Jr., David Rider Jun 2025

In Memoriam: Donald B. Thomas, Jr., January 26, 1949–November 10, 2024, Brett C. Ratcliffe, Joseph E. Eger Jr., David Rider

Insecta Mundi

We honor the life and contributions of Donald Byron Thomas, Jr. (January 26, 1949–November 10, 2024) with a short review of his professional life followed by three appendices listing his published papers, taxa described, and patronyms.


Kinematic Analysis Of Olympic And Traditional Rowing Mechanics At Different Stroke Rates, Alfonso Penichet-Tomas, Sergio Calavia-Carvajal, Basilio Pueo, Lamberto Villalon-Gasch Jun 2025

Kinematic Analysis Of Olympic And Traditional Rowing Mechanics At Different Stroke Rates, Alfonso Penichet-Tomas, Sergio Calavia-Carvajal, Basilio Pueo, Lamberto Villalon-Gasch

International Journal of Exercise Science

International Journal of Exercise Science 18(7): 610-621, 2025. Rowing requires strength, endurance, and technique, where stroke efficiency depends on body mechanics, movement sequencing, and stroke rate, which impact speed transfer. This cross-sectional study investigates the role of kinematic differences in stroke mechanics as a key component of performance analysis in Olympic and Traditional rowing. Thirteen elite national-level female rowers (age: 26.9 ± 5.1 years; body mass: 60.6 ± 6.9 kg; height: 166.7 ± 6.7 cm) performed three stroke-rate conditions on two ergometer setups: an Olympic rowing ergometer and a modified ergometer with a static seat replicating Traditional rowing. The stroke …


The Effect Of Breakfast On A Resistance Training Session And Response In Female Collegiate Athletes, Haley Roberts, Yvette Figueroa, Jennifer Bunn, Patrick Davis Jun 2025

The Effect Of Breakfast On A Resistance Training Session And Response In Female Collegiate Athletes, Haley Roberts, Yvette Figueroa, Jennifer Bunn, Patrick Davis

International Journal of Exercise Science

International Journal of Exercise Science 18(6): 591-609, 2025. Breakfast consumption has been shown to be an essential component to a healthy lifestyle in various populations, yet research in this area is limited among female athletes. This study aimed to examine the effect of breakfast consumption on collegiate female athletes during a resistance training session and their nutritional habits throughout the remainder of the day. Twenty-three female collegiate Division I athletes (basketball, volleyball, bowling, and soccer) during the offseason participated in this cross-over study. The study included three visits: baseline measures for heart rate (HR), blood glucose (BG), salivary cortisol (SC), …