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Biofunctional Characterization Of A Polyherbal Formulation, Muhammad Ameer Qarib Naqvi, Iqra Saleem, Fatma Hussain

Journal of Bioresource Management

Polyherbal formulations (PHFs) have greater medicinal importance due to their enhanced bioactivities. To check whether a combination of several plants enhances bioactivities, the current study was designed. Methanol, aqueous and n-hexane solvents were used to prepare PHF of Syzgium cumini, Origanum vulgare, Aloe vera barbadensis Miller and Gymnema sylvestre. DPPH (2, 2-diphenyl-1-picrylhydrazyl scavenging) assay was used to analyze antioxidant activity. The total phenolic content (TPC) and total flavonoid content (TFC) estimations were done by Folin-Ciocalteu reagent and AlCl₃ colourimetric techniques, respectively. Bactericidal activity was measured by agar well diffusion method, anti-diabetic profile was assessed by …

Impact Of Optimized Irrigation Scheduling On Wheat Growth, Yield And Water Use Efficiency Under Arid Conditions, Muhammad Arshad Khan, Ashiq Saleem, Muhammad Mansoor, Abdul Fatah Soomro, Haroon Shahzad

Journal of Bioresource Management

Improving water use efficiency is crucial since, in Pakistan, water is the main resource that limits crop productivity. A field study was conducted using a Randomized Complete Block Design (RCBD) with four replicates at the research farm of the Arid Zone Research Centre, Dera Ismail Khan, to determine the effects of altered irrigation schedules on wheat growth, yield and water use efficiency (WUE). LI₁ and LI₂ (90 and 60 mm irrigation) at crown root, tillering and milking stages, LI₃ (60 mm irrigation) at crown root and tillering stages and (90 mm irrigation) at milking stage, and LI …

Water Quality And Plankton Diversity Of Ahi River, Ohiya, Umuahia, Nigeria, Emeka Donald Anyanwu, Egor Katkov, Udeme Effiong Jonah, Amarachuku Ezinne Oji, Immaculate Chiamaka Enwereuzo

Journal of Bioresource Management

The plankton diversity of large and urban rivers has been extensively studied in Nigeria while small rural rivers that harbour rich aquatic biota receive little attention. The composition, abundance, and distribution of plankton of a rural river were assessed in relation to some physicochemical parameters. The study was carried out between May and October 2023 in 3 stations using standard methods. The physicochemical results were: temperature (25.2-27.0^oC), flow velocity (0.15-0.46 m/s), transparency (14.0-78.5cm), depth (51.0-105.0cm), pH (5.6-7.8), electrical conductivity (66.0-98.0 µS/cm), total dissolved solids (33.0-49.0 mg/l), turbidity (0.1-1.7 NTU), dissolved oxygen (3.2-6.4 mg/l), biochemical oxygen demand (1.0-2.7 mg/l), …

Towards Computational Methods In Medical Data Analysis: From Speech And Text To Imaging, Kristin Qi

Graduate Doctoral Dissertations

Early detection of cognitive decline and efficient medical image analysis remain critical challenges in healthcare. Traditional clinical assessments are infrequent and resource-intensive, while everyday speech data and unlabeled medical images remain largely unexploited. This dissertation develops computational methods integrating machine learning and artificial intelligence across speech, text, and imaging modalities to address challenges in medical data processing. For cognitive monitoring, this work first introduces methods using voice assistant systems to collect longitudinal speech data in home environments, demonstrating that incorporating historical session patterns significantly enhances detection of mild cognitive impairment. Building on this foundation, a framework combining large language model-driven …

Psoriasis Treatments In The Stabilization Of Atherosclerosis: A Systematic Review, Lixin Ji, Sowmya Ravi, Laura Wright, Vi Nguyen, Jose Wiley, Milena Vukelic, Sangkyu Kim

School of Medicine Faculty Publications

This systematic review explores the relationship between achieving minimal disease activity in psoriasis and the progression of atherosclerosis. It investigates how biologic therapies and other treatments impact atherosclerosis markers, offering insights into therapeutic strategies. A comprehensive search of PubMed, Embase, and Web of Science was conducted from January 1, 2000, to April 1, 2023, using terms such as psoriasis, psoriatic arthritis, atherosclerosis, biologic therapy, vascular stiffness, carotid intima-media thickness (CIMT), and coronary computed tomography angiography (CCTA). Eligible studies were those involving human subjects over 18, written in English, that provided quantitative atherosclerosis markers, including CIMT, CCTA, arterial pulse wave velocity …

Impact Of Chilling, Freezing, And Repeated Freeze–Thaw Cycles On Physical Quality Of Buffen, Chevon, And Chicken Meat, Tarique Ahmed Khokhar, Atta Hussain Shah, Muneer Ahmed Jamali, Asghar Ali Kamboh, Faiz Muhammad Khand, Muhammad Awais Soomro, Zafar Ali Khoso, Muhammad Mohsen Rahimoon

Journal of Bioresource Management

Chilling, freezing, and repeated freeze–thaw cycles are common meat preservation methods; however, they can alter key physicochemical properties. Comparative data across different species under standardized conditions are limited. To compare the effects of chilled storage, frozen storage, and repeated freeze–thaw cycles on pH, water-holding capacity (WHC), thaw loss, cooking loss, and drip loss in buffen (buffalo), chevon (goat), and chicken meat. Longissimus dorsi muscles from buffalo and goat, and breast meat from broiler chickens, were stored under chilled (2–4 °C), frozen (–10 to –12 °C), or repeated freeze–thaw conditions. "Measurements were performed at defined intervals of chilling, freezing and freeze …

Dcpr: A Deep Learning Framework For Circadian Phase Reconstruction, Xiao Han, Xiaochen Cen, Zhijin Li, Xiaobo Zhou, Zhiwei Ji

Faculty, Staff and Student Publications

Background: The circadian clock is an evolutionarily conserved system that orchestrates 24-h physiological rhythms through transcriptional and translational feedback loops. Mounting evidence suggests a bidirectional relationship between circadian rhythm alteration and disease progression, positioning the circadian clock as a potential therapeutic target. Due to the scarcity of high-resolution temporal omics data, it remains very challenging to elucidate the underlying regulatory mechanisms of the circadian system. As a practical alternative, public untimed transcriptomic datasets offer the potential to infer gene expression oscillations retrospectively. However, existing computational approaches for circadian phase estimation often suffer from limited predictive accuracy, reducing their ability to …

Electrochemical Sensors Based On Graphene Oxide/Pedot:Pss Composite Decorated With Bimetallic Gold–Silver Nanoparticles For H2o2 Detection, Rayyan Azzahra Hidayat, Budi Riza Putra, Munawar Khalil, Wulan Tri Wahyuni

Makara Journal of Science

Hydrogen peroxide (H₂O₂) is a biomarker that indicates oxidative stress levels in the human body; thus, rapid and accurate detection methods are necessary to diagnose various disorders. This study developed a nonenzymatic electrochemical sensor for detecting H₂O₂ using bimetallic gold–silver nanoparticles (Au–Ag NPs) combined with graphene oxide and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)-modified glassy carbon electrode. The surface properties of the modified electrodes were characterized using scanning electron microscopy–energy dispersive spectroscopy and atomic force microscopy. The electrochemical performance of the modified electrodes was evaluated using cyclic voltammetry, electrochemical impedance spectroscopy, and differential pulse voltammetry. The bimetallic Au-Ag …

In Silico Target Identification For Antioxidant And Anti-Inflammatory Activity Of Oil Palm Leaves Extract After Biotransformation Process, Galuh Permatasari, Irma Kresnawaty, Annisa Aulia Aksa, Djoko Santoso, Widodo Widodo

Makara Journal of Science

Oil palm leaf extract (OPLE) contains abundant phenolic and flavonoid compounds with recognized antioxidant and anti-inflammatory potential; however, its pharmacological applications remain underexplored. This study aimed to optimize the enrichment process of OPLE and characterize its bioactive compounds using integrated in vitro and in silico approaches. The extraction was optimized by incorporating trichloroacetic acid and extending the incubation time to 48 h, resulting in significantly increased total phenolic content and antioxidant activity compared with the control. LC–MS/MS profiling identified 14 flavonoid compounds with diverse biological functions. Among these, Rhamnetin-3-O-β-D-glucopyranoside, Kaempferol-3-O-rutinoside, and Nelumboroside A exhibited the strongest antioxidant and free radical …

Development Of Shigella Flexneri Detection Method By Real-Time Polymerase Chain Reaction Targeting The Sfmd Gene, Muktiningsih Nurjayadi, Puan Aqila Azizah, Agus Setiawan, Ananda Indah Putri Sihombing, Anisa Fitriyanti, Grace Grace, Gusti Angieta Putri, Helzi Angelina, Royna Rahma Musie, Jefferson Lynford Declan, Gladys Indira Putri, Dandy Akbar Juliansyah, Siti Fatimah, Tiara Fahriza, Irma Ratna Kartika, Fera Kurniadewi, Novitasari Novitasari, Bassam Abomoelak, Hesham Ali El Enshasy, Shyi-Tien Chen

Makara Journal of Science

Shigella flexneri can cause shigellosis, which results in high fever, vomiting, diarrhea, or death. This study developed a detection method based on real-time polymerase chain reaction that targets the sfmD gene of S. flexneri given that the virulence factor encoded by this gene is thought to facilitate adhesion to a host surface. The proposed method involves primer design, DNA isolation, the optimization of primer annealing temperature, and confirmation, specificity, and sensitivity tests. A sfmD primer with an amplicon length of 155 bp was annealed to the target DNA at an optimized temperature of 60 ℃ (range 54 °C–62 °C). This …

Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇

Turkish Journal of Agriculture and Forestry

The nutritional adjustment of food products has gained popularity in recent years as consumer interest in healthy eating has increased. Cake is a widely consumed cereal-based product containing such key nutrients as carbohydrate, fat, protein, fiber, vitamins, and minerals. In the present study, crust and crumb color, specific volume, microstructure, antimicrobial activity, total phenolic content, antioxidant activity, and sensory analyses were evaluated in four cake groups: a control cake (IT0) and cakes supplemented with 1% (IT1), 3% (IT2), and 5% (IT3) nettle seed powder. The addition of nettle seed powder to the cakes significantly reduced the crust (L*, a* and …

Mango Leaf Disease Detection And Classification Using A Federated Learning Based Lightweight Vision Transformer Model, Vinay Gautam, Prabhjot Kaur, Anand Muni̇ Mishra, Achyut Shankar, Laxman Singh

Turkish Journal of Agriculture and Forestry

The detection and management of horticultural crop diseases is crucial for enhancing productivity, reducing costs, and promoting environmentally sustainable practices. Recently, various techniques have been developed for managing crop-related issues, including leaf diseases and pest control. A centralized control approach has been implemented for disease detection. This centralized system faced significant challenges, including concerns over data privacy and the costs associated with data migration. This study addressed the problems with centralized solutions through a federated learning approach enhanced by the attention mechanism of the vision transformer (ViT). We investigated the key features of the federated learning method and propose a …

Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li

Turkish Journal of Agriculture and Forestry

Spectral analysis methods can nondestructively assess the quality of agricultural products but are limited by imaging speed and equipment costs. Therefore, they have not yet been fully integrated into engineering practices. This paper presents JujubeNet, a two-stage hyperspectral reconstruction model for detecting moisture content in jujubes. The first stage utilizes a generative pretrained Pix2Pix generative adversarial network (GAN) to generate RGB images of jujubes that mimic real camera styles and are pixel-to-pixel aligned with hyperspectral images. The second stage uses a transformer-based spectral reconstruction model to achieve hyperspectral reconstruction. Additionally, we developed a moisture content detection model based on hyperspectral …

Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen

Turkish Journal of Biology

Background/aim: Oxidative stress is a major contributor to melanocyte dysfunction and hair graying by impairing key signaling pathways. Eucommia ulmoides bark extract (EUE), rich in antioxidant phytochemicals, has shown potential in combating oxidative damage. This study investigated the protective and promelanogenic effects of EUE under hydrogen peroxide (H₂O₂)-induced oxidative stress, with a focus on the Wnt/β-catenin signaling pathway. Materials and methods: An oxidative stress model was established using B16 cells and a C57BL/6 mouse hair follicle model. Results: EUE significantly improved melanocyte survival and reduced intracellular reactive oxygen species (ROS). Mechanistically, EUE activated the Wnt/β-catenin pathway, leading to upregulation of …

Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman

Turkish Journal of Agriculture and Forestry

Perfluoroalkyl substances (PFASs) are synthetic organic compounds that have not been extensively studied in natural environments. The current study aimed to explore how PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorotetradecanoate (PFTeDA), and perfluorobutanoate (PFBA), affect rice plants and influence their metabolism. These substances had a notable impact on root and shoot growth, reducing fresh and dry weights across various treatments compared to the control. These attributes were the least affected by PFOS treatment. PFBA treatment had significant adverse effects on chlorophyll a, b, and total chlorophyll levels, followed by the effects of PFHxA and PFTeDA. …

Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak

Turkish Journal of Agriculture and Forestry

Sugar bean (Phaseolus vulgaris L.) is a legume of notable nutritional and functional value, and its genotypes have substantial variation in bioactive compounds, antioxidant activity, mineral composition, and enzyme inhibition properties. This study aimed to comprehensively evaluate the biochemical and functional diversity of 10 sugar bean genotypes using data mining algorithms to identify superior candidates for functional food and nutraceutical development. Associations between the phytochemical profiles of sugar bean genotypes and their bioactivity, antioxidant capacity, and enzyme inhibition were modeled with classification and regression trees (CART), random forests (RF), and multivariate adaptive regression splines (MARS), while one-way ANOVA quantified varietal …

Effects Of Auricular Point Acupressure On Inflammatory Signaling In Chronic Low Back Pain: A Secondary Analysis Of A Randomized Controlled Trial, Nada Lukkahatai, Hongyu Wang, Xinran Huang, Wanqi Chen, Hulin Wu, Jennifer Kawi, Zhiyin Yu, Constance M Johnson, Paul Christo

Faculty, Staff and Student Publications

Objective: Auricular point acupressure (APA) has shown promise for pain relief, but its biological mechanisms remain unclear. This study examined the effects of APA on inflammatory cytokines and explored the relationships between changes in inflammatory markers and clinical outcomes in older adults with chronic low back pain (cLBP).

Method: This secondary analysis utilized plasma samples from a three-arm randomized controlled trial (RCT) (NCT03589703) with 272 participants aged 65 years and older with cLBP. The participants were randomly assigned (1:1:1) to the targeted APA (T-APA), nontargeted APA (NT-APA), or education control (CG) groups for four weeks. Cytokine levels were …

Microglial Expression Of Serotonin Receptors Reveals Parallel Regulation Of 5-Ht2b And Bdnf In The Rat Hippocampus, Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin

School of Graduate Studies Faculty Publications

Growing evidence suggests that psychiatric disorders are characterized by a prolonged inflammatory state, which may influence the efficacy of compounds targeting serotonin. Serotonin is a key signaling molecule in neuroplasticity of the adult hippocampus and involved in antidepressant action. Recent in vitro studies indicate the neurotransmitter may also facilitate the response to inflammation and potentially modulate microglial function towards neuroprotection. Using Tph2−/− rats depleted of brain serotonin, we examined microglial expression of various serotonin receptors (5-HTRs) in vivo in both the hippocampus and prefrontal cortex and assessed mRNA levels of cytokines and brain-derived neurotrophic factor (BDNF). We observed age-dependent and …

Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük

Turkish Journal of Agriculture and Forestry

Citrus is one of the most important and widely cultivated fruit crops globally. However, its productivity is increasingly threatened by various diseases, with bacterial infections being particularly the most destructive. Among these, citrus canker, caused by Xanthomonas axonopodis pv. citri (Xac), poses a significant challenge, requiring effective management strategies. Traditional approaches have shown limited success, but nanotechnology has emerged as a promising alternative for disease control. In this study, Xanthomonas spp. was isolated from two locations: Koont Farm and the National Agricultural Research Centre (NARC) citrus orchards in Islamabad, Pakistan. The isolates were identified through morpho-biochemical methods. Moreover, three Bacillus …

Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang

Turkish Journal of Agriculture and Forestry

This study investigates the impact of long-term fertilization modes on crop health and productivity using unmanned aerial vehicle (UAV)-assisted monitoring and a Q-learning-based approach for optimized fertilization strategies. An approximate state-matching Q-learning algorithm was developed to improve the efficiency of agricultural UAVs in fertilization tasks. The spatiotemporal patterns of cultivated land productivity under different fertilization regimes were analyzed in a long-term experiment. An evaluation system for cultivated land health productivity was established. The results indicated that the Q-learning algorithm enabled UAVs to achieve efficient task completion. QLASM outperformed traditional methods on all metrics. QLASM achieved a 92% task completion rate …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu

Turkish Journal of Biology

Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …

Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Taxane resistance remains a significant challenge in the effective treatment of castration-resistant prostate cancer (CRPC). Given the association of epigenetic regulation with chemotherapy resistance and cancer progression, this study aims to identify epigenetic vulnerabilities in two CRPC cell lines (DU145 and 22Rv1) established as resistant to two different taxanes, docetaxel (Dtx) and cabazitaxel (Cbz), using a small-molecule screening approach. Materials and methods: A small-molecule library targeting epigenetic regulators, including histone deacetylases (HDAC), histone methyltransferases, histone demethylases, bromodomain proteins, deoxyribonucleic acid methyltransferases, protein arginine deiminase, and histone acetyltransferase was utilized. Drug screening was performed on parental and taxane-resistant CRPC cell …

In Vitro Antibiofilm Activity Of Tyrosol Against Single And Dual-Species Biofilms Of Candida Tropicalis And Streptococcus Mutans, Zarifeh Adampour, Betül Yilmaz Öztürk, Bükay Yeni̇ce Gürsu, İlknur Dağ

Turkish Journal of Biology

Background/aim: The cross-kingdom biofilm structure formed by Candida tropicalis and Streptococcus mutans may increase caries formation. The aim of this study was to evaluate the in vitro effect of the exogenous tyrosol on single- and dual-species biofilms as well as planktonic cultures formed by C. tropicalis and S. mutans. Materials and methods: The antimicrobial efficacy of tyrosol was evaluated through broth microdilution, colony-forming unit (CFU) enumeration, and XTT reduction tests to assess cell viability and metabolic activity. Transmission electron microscopy (TEM) was used to examine ultrastructural changes in planktonic cells. Biofilm dynamics were visualized via scanning electron microscopy (SEM) and …

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …

6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar

Indian Journal of Research in Homoeopathy

Background: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: …

Potency Dependent Angiogenic Effect Of Bellis Perennis On In Ovo Chick Chorioallantoic Membrane Assay, Jayanthdevan V, Winston Vargheese V, Anish Fathima K, Lohita S

Indian Journal of Research in Homoeopathy

Background: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis …

Black Bone Mri Morphometry For Mandibular Cortical Bone Measurement In Head And Neck Cancer Patients: Prospective Method Comparison With Ct, Lisanne V Van Dijk, Juan Ventura, Kareem A Wahid, Lin L Zhu, Brigid A Mcdonald, Sara Ahmed, Keith L Sanders, Sonja M Stieb, Lance Mccoy, Christina S Sharafi, Kathryn E Preston, Natalie A West, Sarah Mirbahaeddin, Dina M El-Habashy, Travis Salzillo, Samuel Mulder, Joly Fahim, Aubryane Dearmas, Mona Arbab, Yao Ding, Jihong Wang, Bastien Rigaud, Anando Sen, Mark Chambers, Katherine A Hutcheson, Kristy K Brock, Abdallah S R Mohamed, Stephen Y Lai, Clifton D Fuller

Faculty, Staff and Student Publications

Objectives: Determine the utility of low-flip angle "black bone" magnetic resonance imaging (MRI) for cortical mandibular bone assessment compared to computed tomography (CT).

Methods: Quantification of cortical mandibular bone width was performed per Hamada et al. at 15 cross-sectional interdentium locations on pretreatment black bone MRI and CT for 15 oropharyngeal cancer patients, with interobserver analyses on a subset of three patients by 11 observers. CT and MRI measurements were compared using Bland-Altman analysis, Lin's concordance, and Deming regression; interobserver variability was assessed with absolute variance and intraclass correlation coefficient (ICC).

Results: Bland Altman and Deming regression analyses showed CT …

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …