Digital Commons Network^™

Optimized Deep Learning Framework With H2o For Lung Cancer Prediction, Walaa Hassan Ibrahim, Mohamed S. Saraya, Sally M. Elghamrawy, Ali I. Eldesouky

Mansoura Engineering Journal

The automatic diagnosis of lung cancer using chest X-ray (CXR) images has significantly advanced with progress in computing, machine learning, and deep learning. However, detecting lesions and nodules remains challenging due to CXR limitations. Early lung cancer detection is critical for successful treatment, but current AI algorithms often rely on large annotated datasets, which are not always available. To address this, a novel multi-classification deep learning framework is proposed that combines CXR and CT images. This approach leverages the detailed feature detection capabilities of CT scans alongside the complementary views from CXRs, improving early-stage lung cancer detection and classification precision. …

Prenatal Stress Induces Changes In Behavior, Hpa Axis, Inflammation, And Oxidative Stress In Adult Rats Offspring, Jorge M Aguiar-Geraldo, Jefté Peper-Nascimento, José Henrique Cararo, Taise Possamai-Della, Alexandra I Zugno, Anilkumar Pillai, João Quevedo, Samira S Valvassori

Faculty, Staff and Student Publications

Prenatal stress is related to the development of psychiatric disorders involving inflammation, oxidative stress, and hypothalamic-pituitary-adrenal (HPA) axis. Therefore, the aim of the present study was to evaluate the effects of prenatal stress on behavior, inflammation, oxidative stress, and the HPA-axis in the dams and their offspring treated with lithium. Thirteen pregnant Wistar rats were exposed to a prenatal chronic unpredictable stress protocol from the 14th day of gestation until birth. At the 60th postnatal day (PND), a treatment protocol was carried out in the offspring with lithium (intraperitoneally - 47.5 mg/kg) or saline for seven days (twice a day). …

Profiling The Genomic Landscape And Evolutionary History Of Polyploid Giant Cancer Cells In Undifferentiated Pleomorphic Sarcomas, Amy L Bowes, Sara Waise, Tom Lesluyes, Thomas Butters, Christie English, Haixi Yan, Annelien Verfaillie, Christopher Davies, Jianan Chen, Emma Nye, Richard Stone, Jiten Manji, Adrienne M Flanagan, Jonas Demeulemeester, Maxime Tarabichi, Nischalan Pillay, Peter Van Loo

Faculty, Staff and Student Publications

Polyploid giant cancer cells (PGCCs), characterised by multinucleation and atypical nuclear morphology, are a common feature of undifferentiated pleomorphic sarcomas. While PGCCs may be a critical substrate for cancer evolution, their formation pathways and genomic consequences remain underexplored. In this study, we characterise PGCCs in ten pleomorphic sarcomas and use topographic single-cell DNA sequencing (scDNA-seq) to investigate their genomic landscape. We selected PGCCs based on their nuclear morphology, including mononucleated or multinucleated bizarre, misshapen nuclei, and analysed them at single-cell resolution. Histopathological analysis showed that PGCCs were often randomly distributed throughout the tumour and did not appear in clusters, suggesting …

Profiling The Genomic Landscape And Evolutionary History Of Polyploid Giant Cancer Cells In Undifferentiated Pleomorphic Sarcomas, Amy L Bowes, Sara Waise, Tom Lesluyes, Thomas Butters, Christie English, Haixi Yan, Annelien Verfaillie, Christopher Davies, Jianan Chen, Emma Nye, Richard Stone, Jiten Manji, Adrienne M Flanagan, Jonas Demeulemeester, Maxime Tarabichi, Nischalan Pillay, Peter Van Loo

Faculty, Staff and Student Publications

Polyploid giant cancer cells (PGCCs), characterised by multinucleation and atypical nuclear morphology, are a common feature of undifferentiated pleomorphic sarcomas. While PGCCs may be a critical substrate for cancer evolution, their formation pathways and genomic consequences remain underexplored. In this study, we characterise PGCCs in ten pleomorphic sarcomas and use topographic single-cell DNA sequencing (scDNA-seq) to investigate their genomic landscape. We selected PGCCs based on their nuclear morphology, including mononucleated or multinucleated bizarre, misshapen nuclei, and analysed them at single-cell resolution. Histopathological analysis showed that PGCCs were often randomly distributed throughout the tumour and did not appear in clusters, suggesting …

Physiological And Neurological Impact Of Biophilic Design In Architectural Design Studios: A Case Study Of King Salman International University, Islam Ashraf Mohamed, Alaa El-Eishy, Marwa A. Soliman

Mansoura Engineering Journal

Biophilic design integrates nature into architecture to enrich sensory and cognitive experiences, enhance psychological well-being, and improve performance. This study explores its physiological and neural effects in design studios at King Salman International University through an experimental methodology combining theoretical review and lab-based investigation. Tools included electrocardiography (ECG) for heart rate variability (HRV), eye-tracking for visual attention, and the Self-Assessment Manikin (SAM) for emotional evaluation. Nine participants viewed five digital architectural scenes with varying biophilic integration. Direct nature connections elicited greater visual attention, pleasure, and perceived control, indicating higher engagement and relaxation.  A scene lacking biophilic elements led to reduced …

Evaluation Of The Posterior Segment Of The Dromedary Camel’S Eye Using Spectral-Domain Optical Coherence Tomography (Sd-Oct), Amine Berghiche, Djallal Eddine Rahmoun, Nassiba Reghaissia, Allaoua Chaouki Bentazir, Mohamed Kamal Merai Abdel Maksoud

The Thai Journal of Veterinary Medicine

The dromedary camel possesses unique ocular adaptations enabling survival in harsh desert environments. This study aimed to characterize the posterior segment of the dromedary camel’s eye using spectral-domain optical coherence tomography (SD-OCT) and fundus photography. Fourteen healthy adult camels were sedated and imaged. High-resolution OCT images enabled clear visualization and measurement of the retina, choroid, and sclera. The retina exhibited well-defined layers, including the retinal pigment epithelium, photoreceptor layer, plexiform layers, and nerve fiber layer. Mean thicknesses of the retina, choroid, and sclera were 267 ± 2.54 μm, 299 ± 3.15 μm, and 155 ± 2.74 μm in the right …

Exosome Engineering For Blocking Gut Dysbiosis And Inducing Cell Death Mechanisms In Glioblastoma Multiforme, Ahalya Muraleedharan, Karthik Rangavajhula, Swapan K. Ray

Faculty Publications

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults. Emerging evidence endorses that gut dysbiosis contributes to GBM progression through the gut–brain axis (GBA), promoting inflammation and therapeutic resistance via abnormal short-chain fatty acid production and cytokine dysregulation. Exosomes, naturally occurring nanovesicles (30–150 nm), offer promising therapeutic potential due to their blood–brain barrier permeability, biocompatibility, and versatile cargo capacity. This review examines exosome engineering strategies for dual targeting: inhibiting alterations in gut microbiome and inducing regulated cell death mechanisms such as apoptosis and ferroptosis in GBM. We describe exosome engineering with detailed focus on cargo loading approaches …

Effect Of Hdl Disk And Ldl Dimer Presence On Lipoprotein Particle Number Determination And Subclassification, Zsuzsanna Kuklenyik, Anna A. Ivanova, Lauren E. Drinkard, David M. Schieltz, Jeffrey I. Jones, Kevin Bierbaum, Christopher A. Toth, Michael S. Gardner, Bryan A. Parks, Michael Andrews, Jennifer D. Kusovschi, Jack A. Sultan, Antony Lehtikoski, Jon C. Rees, Wanda I. Santana, Victoria Connor, Eric Leszynski, Robert W. Mcgarrah Iii, Mark A. Sarzynski Facsm, William E. Kraus, John R. Barr

Faculty Publications

High-density and low-density lipoproteins (HDL and LDL) are established analytical targets for diagnosis and risk stratification of numerous chronic diseases. This study investigates potential sources of bias in lipoprotein particle counting (HDL-P and LDL-P), focusing on the most atheroprotective small-HDL and most pro-atherogenic small-LDL. Plasma samples were fractionated using asymmetric-flow field-flow fractionation (AF4), coupled with hydrodynamic size measurement and comprehensive liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of each fraction. Concentration-size profiles were deconvoluted into 10 HDL and 8 LDL Gaussian subspecies. Molecular volume ratios were used to evaluate proposed particle models, providing evidence for the presence of s-HDL disk and …

Differential Response Of Finger Millet Accessions To Contrasting Saline Water Levels And Irrigation Regimes Under Desert Conditions, Abidemi Talabi, Nhamo Nhamo, Sumitha Thushar, Prashant Vikram, Hifzurrahman Rahman, Mohammed Shahid, Neeru Sood, Malavika Sudheer, Dheeraj Thikkamaneni, Amna Almarri, Fatma Alsaffar, Deep Galani, Moyeez Alam, Sonia Goel, Rakesh K. Singh

All Works

Water salinity and scarcity constitute major limitations to crop production in arid and semi-arid regions. Introduction of nutritious and stress-tolerant underutilized crops is a promising approach for dietary enrichment, cropping system diversification, remediation of marginal and degraded lands, and building climate resilience. The primary objectives of this study were to investigate the effect of water salinity and managed water-deficit stress on grain and fodder yield, identify multi-trait ideotypes, and validate the stability and genetic gain in finger millet ideotypes over a 2-year period. A total of 80 finger millet accessions were evaluated under fresh water (0 dS/m) and two saline …

Influence Of Weekend Social Jetlag On Glucose Tolerance Testing, Ariana Khzarjyan, Srushti Wagh, Graham Mcginnis

Kinesiology and Nutrition Sciences Student Research

Background: Circadian rhythms regulate physiological and metabolic functions across a 24-hour cycle. However, modern lifestyles often disrupt these rhythms. A common example is weekend schedule shifts, when people sleep and wake later than on weekdays, a phenomenon referred to as social jetlag (SJL).

Purpose: The purpose of this study was to; 1) determine whether chronic SJL leads to impaired glucose tolerance, and 2) determine if acute changes in glucose tolerance occur following a weekend of social jetlag (SJL).

Methods: Fifteen male C57BL/6 mice on a normal chow diet were used in this study. To model social jetlag (SJL), mice were …

Bone Marrow Endosteum Houses Hedgehog-Susceptible Dlx5-Expressing Osteoblast Precursor Cells, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5

Phase I Trial Of Binimetinib Plus Hydroxychloroquine In Patients With Previously Treated Metastatic Pancreatic Cancer, S Daniel Haldar, Fen Saj, So Jung Hong, Rishi Surana, Lianchun Xiao, J Jack Lee, Brandon Smaglo, Dan Zhao, Huili Zhu, Ryan Huey, Jason Willis, M Pia Morelli, Michael Overman, Florencia Mcallister, Robert Wolff, Anirban Maitra, David Fogelman, Channing Der, Shubham Pant

Faculty, Staff and Student Publications

Background: Dual mitogen-activated protein kinase (MAPK) pathway and autophagy inhibition shows synergistic antitumor activity in preclinical models of RAS-mutant cancers. We hypothesized that autophagy blockade with hydroxychloroquine (HCQ) could overcome resistance to MEK inhibition with binimetinib (BINI) and provide clinical benefit in previously treated, KRAS-mutated, metastatic pancreatic ductal adenocarcinoma (PDAC).

Methods: This investigator-led, single-arm, open-label, phase I dose escalation/expansion trial evaluated the safety and tolerability of BINI + HCQ in patients with previously treated, metastatic PDAC (NCT04132505). Key eligibility criteria: ECOG 0-1, adequate organ function, ≥ 1 prior line of therapy for metastatic disease, and presence of KRAS …

Endosteal Stem Cells At The Bone-Blood Interface: A Double-Edged Sword For Rapid Bone Formation: Bone Marrow Endosteal Stem Cells Provide A Robust Source Of Bone-Making Osteoblasts Both In Normal And Abnormal Bone Formation, Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non-endosteal perisinusoidal niche. Single-cell molecular profiling and in vivo cell lineage analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor-making cells when deleterious mutations occur in …

Functional Characteristics Of Ice Creams Enriched With Aronia Melanocarpa And Sambucus Nigra L. Extracts, Murat Emre Terzi̇oğlu, Emi̇ne Maci̇t

Turkish Journal of Agriculture and Forestry

In this study, the effects of Aronia melanocarpa and Sambucus nigra L. extracts added at different concentrations (0.5%, 1%,and 1.5%) on the physicochemical, sensory, microbiological, antioxidant capacity (DPPH• and ABTS•+ radical scavenging activity, TPC,TFC, and TAC) antidiabetic (α-amylase and α-glucosidase inhibition), and anti-Alzheimer properties (AChE inhibitory activity) of icecream were investigated. According to the statistical analysis results, extract addition did not have an effect on the total dry matter, fatand ash ratios of the ice cream samples (p > 0.05), but it had an effect on the protein ratio, viscosity, and first drip time at the level ofp < 0.05. The addition of extract positively affected the DPPH• radical scavenging activity IC50 and ABTS•+ radical scavenging activityIC50 values of the ice cream samples, and also increased the TPC, TFC, and TAC values. Indeed, a decrease in the IC50 values of DPPH•and ABTS•+ radical scavenging activities indicates an increase in antioxidant activity. The highest TPC, TFC, and TAC values weredetected in the A-1.5 sample (sample containing 1.5% A. melanocarpa extract) as 749.33 mg GA/kg, 434.70 mg QE/kg, and 290.97 mg/kg, respectively. Similarly, the highest α-amylase inhibitory activity (23.08%), the highest α-glucosidase inhibitory activity (10.41%) andthe highest AChE inhibitory activity (14.70%) were observed in the A-1.5 sample. Extract addition had no effect on microbiologicalproperties and sensory properties except texture. The results of this study showed that A. melanocarpa, S. nigra L. extracts can be usedas a natural additive with antioxidant, antidiabetic and anti-Alzheimer activities in ice cream production.

Exploring Molecular And Morphological Diversity Of Ostracoda: A Combined Approach Based On Coi Sequences And Morphological Characters, Serdar Di̇nç, Serap Mutun, Okan Külköylüoğlu

Turkish Journal of Zoology

Ostracods are diminutive aquatic invertebrates with a broad geographical distribution  across a diverse range of aquatic habitats, including lentic and lotic freshwater  environments as well as marine waters. Due to their sensitivity to environmental  changes, ostracods are valuable tools in biodiversity monitoring, providing a link to  past, present, and future ecological conditions. Despite the significance of classical  taxonomic studies in species identification, molecular approaches remain  underutilized in ostracod research, representing an area of potential growth for  advancing our understanding of this diverse group. Thus, molecular studies in  ostracods have the potential to greatly enhance our understanding of morphology,  ecological variation …

Spatial And Temporal Variability Of Mayfly Communities (Insecta: Ephemeroptera) In Mountainous And Semimountainous Rivers Of The Western Aegean Basin, Biljana Rimcheska, Yanka Vidinova

Turkish Journal of Zoology

Mayflies are among the most abundant benthic invertebrates inhabiting natural lotic  freshwater systems. Their assemblages vary with environmental, geographical, and  hydrological conditions along altitudinal gradients and under different types of  watershed disturbance. The main objective of this study was to analyze the  composition and β-diversity of mayflies across three river watersheds and to assess  how these assemblages differ among them. We collected biological and  environmental data from 38 sampling sites distributed across the three river  watersheds. We hypothesized that mayfly assemblages would vary with  environmental gradients on both spatial and temporal scales; specifically, we  expected pristine streams to exhibit higher …

Towards The Assessment Of E-Flows: A Fish-Based Approach For The Tiber River Basin (Central Italy), Antonella Carosi, Francesca Lorenzoni, Fatemeh Zarei, Rachele Brustenga, Lucio Di Matteo, Daniela Valigi, Corrado Cencetti, Carlo Cardellini, Stefano Casadei, David Cappelletti, Massimo Lorenzoni

Turkish Journal of Zoology

Estimating ecological flows (EFs) in rivers is crucial for meeting the Water Framework  Directive (WFD) 2000/60/EC goals. To develop an EF model, it is  essential to use biological indicators to reliably record the impacts of human-induced  alterations on aquatic ecosystems. The adaptability of fish to annual flow variability  makes them a significant biological quality element (BQE). Consequently, using fish  as bioindicators is a powerful tool for assessing the impact of changes in the  hydrological regime on the natural communities within a river system. The new index  of the ecological status of fish communities (NISECI) is a methodology developed in  Italy …

Utah Wildflower Microbes Boost Plant Growth Without Using Chemical Fertilizers, Rebecca Thorley

Research on Capitol Hill

Modern agriculture relies on chemical fertilizers to boost crop yields, but these short-term gains come at a steep cost:

Soil degradation: Chemicals kill beneficial soil organisms and damage soil structure over time

Water pollution: Fertilizer runoff contaminates rivers and lakes, creating toxic algae blooms

Rising costs: Fertilizer expenses now account for 30-50% of crop production costs

Climate impact: Fertilizer production and use generate significant greenhouse gas emissions

The challenge: Feed growing populations while restoring soil health and protecting the environment.

We Can Use Coyotes As A Model To Understand How Social Loss Alters The Brain, Rebekah Rowe

Research on Capitol Hill

While we understand some factors that increase psychological distress for grieving individuals, little is known about this biological basis.

Ovarian Transplants Drastically Improved The Health Of Post-Menopausal Mice, Nathan Mccoy

Research on Capitol Hill

Women generally experience health advantages compared to men before menopause. Following menopause, this advantage diminishes, and women become more susceptible to metabolic and neurodegenerative diseases, including Alzheimer’s disease.

Could Gene Editing Increase Chicken Resistance To Avian Influenza?, Alta Crane

Research on Capitol Hill

Avian Influenza is a viral infection that causes outbreaks of "bird flu," greatly affecting avian health. Influenza A virus (IAV) relies on various host factors for efficient replication. Previous studies in human cells have identified four genes as critical host factors required for IAV infection. To investigate whether similar host– virus interactions exist in avian species, we utilized gene editing systems to generate knockout fibroblast cell lines targeting those four genes and then applied these techniques to germ cells.

Aspen Graffiti Are Close To Trails And On Large-Diameter Trees, James A. Lutz, Soren Struckman, Joseph D. Birch

Wildland Resources Faculty Publications

Key results

1. Close to the trail

75% of all graffiti was within 60 feet of the trail.

2. On the largest trees

Graffiti was concentrated on the largest diameter aspen (larger than 8 in diameter).

3. Higher growth in marked aspen

Aspen with graffiti had 24% higher radial growth, relative to unmarked aspen. This is likely because people carve the healthiest aspen.

Alkaline And Acid Extraction Of An L-Tryptophan–Sunflower Flour Red Colorant: Production, Characterization, And Utilization, Spencer Nguyen, Marissa Wong, Lilian Were Senger

Food Science Faculty Articles and Research

The objective was to produce and characterize a red colorant resulting from interaction of sunflower-derived chlorogenic acid with L-tryptophan/Trp and to evaluate its applications. Yield, intensity, solubility, stability, protein, and metal content of colorants from pH 9 and pH 11 lyophilized sunflower flour- Trp colorants were measured. Red color formation took < 3 h with alkalization and subsequent acidification. The sunflower flour: Trp mixture ratio that produced the greatest redness was 10:2. The highest red pigment was in supernatants and not the precipitates. The red colorant intensity and solubility were highest at neutral pH when compared to acidic pH solutions. The color stability of the new red colorant in icing and refrigerated whole milk matrices, when assessed weekly for a month, showed no color change in refrigerated milk. After 30 min of incubation at 63 °C, pinkness in milk remained unchanged or increased. The pink color, however, faded in icing over time due to exposure to light. The present study established a new natural red colorant developed from sunflower protein-Trp mixtures at alkaline pH, as well as its application in icings and whole milk for commercial strawberry milk products. This colorant could serve as a replacement for the synthetic petroleum-based Red 3.

Changes In Metabolomics And Tissue Architectural Alterations Jointly Ameliorate Salt Mediated Injuries In Nigella Sativa L., Noreen Akhter, Ayesha Ali, Muhammad Aqeel, Muhammad Muslim Shahnaz, Saima Iqbal, Ayesha Riaz, Mohammed O. Alshahrani, Ali Noman, Noreen Khalid, Khairah M. Alwutayd Alomran, Fahad Mohamed Al-Zuibar

Turkish Journal of Agriculture and Forestry

This study evaluated plant resistance to salinity across varying salt concentrations: 0, 50, 100, 150, and 200 mM NaCl. Thestudy revealed how these salt levels affected the morphological, physiological, biochemical, and developmental characteristics of theplants. At the 50 mM NaCl treatment level, plant height dropped by 8% in comparison to the control. The shoot fresh and dry weightsof every plant subjected to different levels of salt stress decreased noticeably. At 200 mM NaCl, the plants fresh weight of root decreasedby the greatest percentage (42.8%). The total number of chlorophyll a and chlorophyll b in Nigella sativa L. was significantly lower …

Accumulation Of Polyphenolic Compounds In Amelanchier × Lamarckii Fruit In Conditions Of Southwestern Slovakia, Luba Durisova, Tunde Jurikova, Monika Ondrasova, Pavol Elias Jr., Deni̇z Hazar, Jiri Mlcek

Turkish Journal of Agriculture and Forestry

In Slovakia, snowy mespilus (Amelanchier × lamarckii F. G. Schroed.) is recognized both as an ornamental plant and alesser-known fruit species, prized for its high levels of bioactive compounds, particularly polyphenols. The aim of this study was todetect the polyphenolic profile of snowy mespilus and to assess polyphenol accumulation in cells. The total polyphenol content wasdetermined by the Folin–Ciocalteu method, antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assayand the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, and individual polyphenolic compounds by the highperformanceliquid chromatography (HPLC) method. The results of analyses revealed that among the phenolic acids, chlorogenicacid was the most prevalent [44.24 …

Examining The Effect Of Different Polycarbonate Greenhouse Cover Materials On Tomato Yield And Plant Development With Thermal Imaging, Candan Korkmaz, Nefi̇se Yasemi̇n Tezcan

Turkish Journal of Agriculture and Forestry

In this study, the effects of different polycarbonate (PC) greenhouse covering materials on the environmental microclimateand plant growth were examined using three research greenhouses. Two types of PC covering materials were tested: the first greenhousewas covered with UV-additive PC (UV PC), the second greenhouse with UV+Infrared (IR) additive PC (UV+IR PC), and the third(control) greenhouse had UV-additive PC on the sidewalls and polyethylene (PE) covering material (UV PC+PE) on the roof. Themeasured fundamental parameters included total radiation transmittance, photosynthetically active radiation (PAR) transmittance,temperature, and relative humidity. Plant development was monitored and leaf temperatures were measured using a thermal camera atvarious …

Bioactive Profile And Mineral Composition Of Fruit Extracts From Four Wild Hawthorn (Crataegus Spp.) Species, Özlem Çakir, Kübra Çinar Topçu, Abdurrahman Sefali, İshak Bayyi̇ği̇t, Gülçe İlhan, Jyoti̇ Singh

Turkish Journal of Agriculture and Forestry

This study compared the antioxidant capacity, total phenolic content (TPC), phenolic composition, lipid oxidation level, andmineral profiles of extracts obtained from four wild hawthorn species (Crataegus tanacetifolia, C. orientalis subsp. orientalis, C. orientalissubsp. szovitsii, and C. monogyna) collected from northeastern Türkiye. Significant interspecific variations were observed in DPPH,FRAP, and CUPRAC assays. While C. monogyna had the highest reducing capacity and TPC, C. orientalis subsp. szovitsii had the highestDPPH activity. Ultra-high performance liquid chromatography coupled to tandem mass spectrometry analysis showed that catechin,epicatechin, chlorogenic acid, and quinic acid were the major phenolics, and were particularly abundant in C. monogyna. Despitehaving a …

Pretreatment Risk Model For Radiation-Induced Lymphopenia Is Associated With Adjuvant Durvalumab Efficacy In Patients With Unresectable Stage Iii Nsclc, Peter S N Van Rossum, Pim J J Damen, Francesco Cortiula, Brian P Hobbs, Lorenzo De Marchi, Radhe Mohan, Max Peters, Famke L Schneiders, Dirk De Ruysscher, Robin Wijsman, Joost J C Verhoeff, Ting Xu, Zhongxing Liao, Steven H Lin

Faculty, Staff and Student Publications

Introduction: Severe radiation-induced lymphopenia (RIL) during concurrent chemoradiotherapy (CCRT) for NSCLC has been associated with poorer outcomes and reduced immunotherapy efficacy. Because RIL often develops late during CCRT, identifying patients at risk before treatment may be clinically relevant. This study aimed to develop and validate a nomogram based on pretreatment predictors for severe RIL, and secondarily to explore associations between predicted RIL risk and adjuvant durvalumab-associated survival.

Methods: A retrospective development cohort of consecutive patients with NSCLC treated with CCRT (2010-2019) was established, along with an independent external validation cohort from other institutions. A multivariable logistic regression model was developed …

Development And Validation Of A Prognostic Risk Score For Patients With Cancer And Neutropenic Fever Presenting To The Emergency Department, Sandy Nath, Aiham Qdaisat, Andriy Derkach, Afia Babar, Deepti Zalavadia, Patrick Chaftari, Ziyi Li, Monica K Wattana, Joseph Schmeltz, Rocio Perez Johnston, Eduardo Ortiz, Kumar Alagappan, Adam Klotz, Sai-Ching Jim Yeung

Faculty, Staff and Student Publications

Objectives: Neutropenic fever (NF) is a life-threatening oncologic emergency associated with significant morbidity and mortality. Current predictive risk-stratification scores' limitations include outdated criteria, subjectivity, and low usage in the emergency department (ED). We sought to develop and externally validate a pragmatic, objective risk score to predict adverse outcomes in patients presenting to the ED with cancer and NF.

Methods: A retrospective cohort study was performed using data from 2 comprehensive cancer centers. The derivation cohort included adults presenting with NF to Memorial Sloan Kettering Cancer Center. External validation was conducted using data from the MD Anderson Cancer Center. The primary …

Pest Management For Utah Cut Flower Production: Insects And Their Relatives, Nick Volesky, Marion Murray, Melanie Stock

All Current Publications

Pest management is important in cut flower production, marketability, and farm profitability. This fact sheet focuses on animal pests (insects, arthropods, mollusks, and vertebrates), not diseases or weeds, and has two parts. Part 1 applies Integrated Pest Management (IPM): using preventive techniques, pest thresholds, and best management practices with pests in cut flower crop production. Part 2 highlights the top 10 common pests of cut flowers in Utah and their management.