Digital Commons Network^™

Land-Use Changes Shape Mosquito Assemblages, Host-Feeding And Arbovirus Infection In Baringo County, Kenya, Caroline Getugi, Elizabeth Kokwaro, Anthony Nyamache, Inga Slothouwer, Gilbert Rotich, Rosemary Sang, Sandra Junglen, David P. Tchouassi

All Peer-Reviewed Publications

Environmental transformation driven by human activity has profound implications for the ecology of mosquito vectors and the pathogens they transmit. This study investigated the influence of land-use change on mosquito assemblages, host-feeding patterns, and arbovirus infection across sylvatic-rural-peri-urban land-use types in Marigat subcounty, Rift Valley, Kenya. Adult mosquitoes were collected using CO₂-baited CDC light traps and BG-Sentinel traps across three sites: Kiborgoch conservancy (sylvatic), Ntepes village (rural) and Marigat town (peri-urban). Sampling was conducted during three sessions including September 2022, August 2023, and December 2023. The mosquitoes were morphologically identified to species, and indices of abundance, richness and diversity compared …

Axillary Management After Neoadjuvant Endocrine Therapy (Net), Laura Leonard, Min Yi, Emma Wingate, Puneet Singh, Abigail Caudle, Rosa F Hwang, Isabelle Bedrosian, Vicente Valero, Jennifer Litton, Nuhad Ibrahim, Kelly K Hunt

Faculty, Staff and Student Publications

BACKGROUND: In patients with hormone receptor-positive (HR

PATIENTS AND METHODS: We performed a retrospective review of patients with clinical stage I-III, HR

RESULTS: A total of 230 patients were included; 120 (52.2%) were clinically node-negative (cN0), while 110 (47.8%) were clinically node-positive (cN+). In the cN+ group, 7.3% (8/110) had a nodal pathologic complete response (pCR). In total, 76.4% (84/110) in the cN+ group underwent axillary lymph node dissection (ALND) as the initial axillary procedure, and 90.9% (100/110) underwent ALND overall. In total, 98.3% (118/120) with cN0 disease underwent sentinel lymph node dissection (SLND), and 28 (23.7%) had positive nodes. …

Global Epidemiology Of Cephalopina Titillator Infestation In Camels: A Systematic Review And Meta-Analysis (1980–2025), Temesgen Mohammed, Aboma Zewude, Tsegaye Shamebo, Layaly Hamdan, Atef Oreiby, Hazim O. Khalifa, Gobena Ameni, Bojan Gajic

All Works

Background – Cephalopina titillator (C. titillator) is the causative agent of camel nasopharyngeal myiasis and is widespread in camel-rearing regions worldwide, causing impaired health, reduced productivity, and economic losses. However, despite the veterinary importance of C. titillator, global epidemiological evidence remains limited and fragmented, and no comprehensive synthesis of prevalence data across camel-rearing regions has previously been conducted. The objective of this review was to estimate the global pooled prevalence of C. titillator infestation in camels. In addition, subgroup analyses were made to assess the effect of camel species, geographic region, and study period on the pooled prevalence of C. …

Dietary Β-Hydroxybutyrate Sodium Alters Rumen Microbiome And Nutrient Metabolism In The Rumen Epithelium Of Young Goats, Yimin Zhuang, Guanglei Liu, Chuyun Jiang, Mahmoud M. Abdelsattar, Yuze Fu, Ying Li, Naifeng Zhang, Jianmin Chai

Animal Science Faculty Publications and Presentations

The role of β-hydroxybutyric acid (BHBA) includes providing energy, regulating signaling pathways, and ameliorating the gut microbiota in the host, while its nutrient mechanism to improve rumen epithelium development in young ruminants is still unclear. In this study, a total of 12 female Haimen goats with 30 d of age were chosen and divided into two groups. One group was fed with basic diet (CON), and the other group was fed a basal diet supplemented with 6 g d^–1 dietary β-hydroxybutyrate sodium (BHBA-Na). The experimental period was 30 d, and all goats were slaughtered at 60 d of age. …

Variable Hybridization Rates Between F2 Fundulus Notatus Females, Jordan Tanaka

Honors Theses

Hybridization between two related species has been widely observed and offers a lens into complex evolutionary processes. Endogenous and exogenous factors affect hybrid fitness and diversification, and pre-zygotic and post-zygotic barriers affect species’ ability to hybridize. Female mate choice is a pre-zygotic isolation mechanism which is known to be more significant than male mate choice in many species, a trend which is linked to females often investing more energy into offspring. Detailing the ways in which these mechanisms operate is integral to understanding hybridization on a larger scale. The species examined here, Fundulus notatus and Fundulus olivaceous, are closely …

Evaluating The Environmental Parameters Impacting Spawning Movement Of Gulf Sturgeon (Acipenser Desotoi) In The Bouie River System., Olivia St. Germain

Honors Theses

The anadromous Gulf Sturgeon (Acipenser desotoi) is federally listed as “threatened” and is natal to seven rivers from Louisiana to Florida. Only one spawning reach for Gulf Sturgeon natal to the Pascagoula River has been verified via the collection of eggs and larvae; a reach of the lower Bouie River. This reach is anthropogenically modified by four gravel mining formations, hereafter referred to as pits. The greater depths associated with this area have prompted previous researchers to suggest that Gulf Sturgeon may over-summer in pit formations instead of migrating to downstream holding areas in the Pascagoula River after spawning. The …

An Insight Into The Venom Gland Proteome Of The Two-Spined Trap-Jaw Ant, Odontomachus Haematodus, Aaron Morgan

Honors Theses

Ants are ecologically important and highly abundant organisms, playing key roles in many ecosystems. One recently introduced species in the southeastern United States is Odontomachus haematodus (the two-spined trap-jaw ant), a South American native that has often been misidentified, contributing to limited research on its biology and venom composition. This study aimed to provide the first detailed characterization of the venom apparatus and proteome of O. haematodus. Specimens were collected and dissected, and venom-related proteins were extracted and analyzed using SDS-PAGE and tandem mass spectrometry (MS/MS-ESI). Confocal microscopy was also used to visualize the sting apparatus, including F-actin filaments and …

Weaning Drives Microbiome-Mediated Epigenetic Regulation To Shape Immune Memory In Mice, Li Yang, Robert C Peery, Shirui Zhou, Xiaomin Chen, Leah M Farmer, Fabiola Gutierrez, Stephanie Fowler, Lanjing Zhang, Julia M Salamat, Karen Riggins, Jiejun Shi, Lanlan Shen

Children’s Nutrition Research Center Staff Publications

During weaning, the transition to solid food diversifies the gut microbiome, triggering a programmed immune response critical for long-lasting mucosal immunity. Previous work showed that the gut microbiome mediates epigenetic development in intestinal stem cells (ISCs) during suckling, but what happens during weaning is unclear. Here, genome-wide profiling revealed that weaning-driven microbiome changes shape the DNA methylome and transcriptome of murine ISCs in an IFNγ-dependent manner. Specifically, we observe demethylation of enhancer elements essential for MHC class II genes, which results in a transcriptional memory that persists through differentiation into adulthood. IFNγ blockade, or low-dose penicillin to target Gram-positive bacteria, …

Growing South Dakota (Spring 2026), College Of Agriculture, Food, And Environmental Sciences

Growing South Dakota (Publication of the College of Agriculture, Food and Environmental Sciences)

[Page] 2 National heritage, statewide research, local impact
[Page] 7 About the South Dakota Agricultural Experiment Stations
[Page] 14 Managing the mooo-ment: How SDSU researchers are looking to improve cow health during the Transition Period
[Page] 18 Discovering strength in science: How education through undergraduate research prepares students for the future
[Page] 20 From India to Brookings: One grad student’s path to make a world of difference in virology
[Page] 22 Solving a billion-dollar problem: Identifying disease-resistent wheat genes
[Page] 24 Unlocking manure’s potential: SDSU leads multistate study on the power of swine manure in growing better crops
[Page] 28 …

Electromyography, Prosthetic Properties, And Running Biomechanics In Recreationally Active Persons With Lower Extremity Amputation, Paige M. Agnew

Rehabilitation Sciences Theses & Dissertations

Lower extremity loss affects nearly 150,000 individuals in the United States yearly yielding extreme health care costs annually. Typically, prosthetic devices are prescribed for 5-8 years despite known changes to an individual’s gait as time progresses. Patients can expect to undergo approximately 8-12 weeks of gait retraining to improve their comfort and efficiency. Biomechanical changes occur when running with a specific running prosthetic including considerable biomechanical and neuromuscular interlimb asymmetries and alterations in loading patterns. The purpose of this dissertation was to investigate the biomechanical demands for lower extremity prosthesis users during running. The first study synthesized peer reviewed evidence …

Role Of Listeria Adhesion Protein In Monocyte-Associated And Extracellular Translocation Of Listeria Monocytogenes Across The In Vitro Placental Barrier Co-Culture Model, Ayesha Atique

Biological Sciences Theses & Dissertations

Listeria monocytogenes is a facultative intracellular foodborne pathogen capable of crossing the placental barrier, leading to miscarriage, stillbirth, and neonatal sepsis, and has a fetal/neonatal fatality rate of ~20–30%. Although the importance of canonical virulence factors such as Internalin A (InlA) and Internalin B (InlB) in L. monocytogenes crossing of the placental barrier has been demonstrated, clinical strains lacking functional canonical internalins have been reported to cause severe neonatal disease, suggesting additional mechanisms of placental translocation.

To investigate these virulence mechanisms, we adapted a physiologically relevant co-culture human placental barrier Transwell model composed of BeWo trophoblasts and primary human placental …

Mechanisms Of Synergy Between Nanosecond Pulsed Electric Field (Nspef) And Cold Atmospheric Pressure Plasma Discharge (Cap) In Pancreatic Cancer: The Role Of Ros-Mediated Oxidative Stress And Apoptosis, Zobia Minhas

Theses and Dissertations in Biomedical Sciences

Pancreatic ductal adenocarcinoma is a highly lethal malignancy characterized by poor prognosis and resistance to conventional therapies. Novel treatment strategies are needed to overcome this resistance. Non-thermal physical modalities, including nanosecond pulsed electric field (nsPEF) and cold atmospheric pressure plasma discharge (CAP), have emerged as potential anticancer approaches; however, the mechanisms underlying their combined effects remain unclear.

This study evaluated whether nsPEF enhances CAP-induced cytotoxicity and investigated the associated molecular mechanisms using the murine Pan02 pancreatic cancer cell line. Cell viability was assessed by WST-1 metabolic activity assays and electric cell–substrate impedance sensing (ECIS). Intracellular reactive oxygen species (ROS) were …

Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton

Computer Science Theses & Dissertations

Alcohol Use Disorder (AUD) is a pervasive condition characterized by complex interplay among genetic, phenotypic, and environmental factors. Although previous studies have identi fied genetic loci associated with alcohol consumption, these efforts have not captured the genetic heterogeneity and gene-environment interactions underlying AUD pathogenesis. To address this critical gap, we developed a novel statistical methodology that integrates phenotypic, genotypic, and environmental data through an environmentally modified Genetic Relationship Matrix (GRM) to derive AUD-related traits with enhanced heritability.

This approach demonstrated superior performance in both simulated and real-world datasets. Traits derived using the environmentally modified GRM exhibited significantly higher estimated heritability …

Comparative Evaluation Of Five Bacterial Strains For The Fermentation Of Camel Milk, Sifatun Nesa Ali

Theses

In this study, the comparative fermentation performance of lactic acid bacteria Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus, Lb. helveticus, Lb. casei, and Lactiplantibacillus plantarum in Camel Milk (CM) and Bovine Milk (BM) was investigated. Fermentations were carried out at 42°C for 48 hours, and was monitored through bacterial growth, titratable acidity, pH evolution, proteolytic activity, microstructural properties, and rheological characteristics. Although comparable bacterial viability was observed in CM and BM, acidification kinetics varied significantly between CM and BM (p < 0.05). Proteolysis was significantly higher in fermented CM than in BM (p < 0.001), with consistently greater o-Phthalaldehyde Assay (OPA) values in CM across all strains during fermentation (p < 0.001). Scanning electron microscopy revealed more porous, loose protein matrices in fermented CM than in BM, which supports the rheological results showing weaker gel networks and lower rheological strength in fermented CM. Among the tested bacteria, Lb. casei demonstrated superior adaptability, enhanced viability, balanced acidification, and favorable rheological properties in both milks. Overall, the results of this thesis demonstrate strain-specific fermentation responses and support the possible suitability of different starter cultures for improving the technological performance of fermented camel milk products.

Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein

OES Theses and Dissertations

The Lafayette River, a shallow, eutrophic tributary of the Chesapeake Bay, experiences seasonal harmful algal blooms (HABs). While management efforts focus on reducing external nutrient inputs, internal loading from benthic sediments remains poorly constrained. This study quantifies spatial and seasonal variability in nutrient and radium isotope fluxes across the sediment–water interface at three sites where HABs are known to initiate and represent contrasting sediment textures and hydrodynamic conditions. Sediment cores and porewater samples were collected in summer 2023 and winter 2024 to measure grain size, porosity, dissolved nutrients (NH₄⁺, NOₓ⁻, PO₄³⁻), and radionuclide activities (²²⁴Ra and ²²⁸Th). Radium isotope disequilibrium …

Characterising Soil Microbial Communities In Thinned And Unthinned Eucalyptus Forest In Southwestern Australia, Aaron J. Brace, Laurence Dugal, Josephine Hyde, Kristen Fernandes, Anna J.M. Hopkins, Emma Stevens, Gavan S. Mcgrath, Katinka X. Ruthrof

Research outputs 2022 to 2026

Climate change stress in forested ecosystems globally has led to die-off events, and management actions are needed to help mitigate these pressures. Forest thinning has been proposed to reduce competition for moisture between trees, however, the effects of forest thinning on lesser-studied organisms, such as soil microbial communities, need quantification. Soil microbial communities are essential for processes such as nutrient cycling and can be used as indicators of below-ground health and as an overall proxy for biodiversity. This study examined soil microbial communities, and site and soil characteristics, directly at the base of trees and in inter-tree spaces in a …

Recombinant Gelonin: Purification And Functional Validation For Electroporation-Assisted Delivery, Eleni Zivla, Giedrė Šilkūnienė, Andrei G. Pakhomov, Mantas Šilkūnas, Olga N. Pakhomova

Knowledge and Creativity Expo

Type I ribosome-inactivating proteins, such as gelonin, are enzymatically potent toxins but are effectively non-toxic under physiological conditions because they are unable to cross the plasma membrane[1]. Pulsed electric fields (PEF) overcome this delivery barrier by transiently permeabilizing the plasma membrane, allowing direct cytosolic entry. This enhances gelonin cytotoxicity by several thousand-fold, highlighting gelonin’s potential as an electrochemotherapy candidate[2]. Here, we present a recombinant gelonin (rGel) expression platform in E. coli with HPLC-based purification that enables reproducible protein production and structure-guided engineering.

The mature gelonin sequence (residues 47–297) was cloned into pET-32a(+) with an N-terminally fused Trx-6×His tag and TEV …

Metabolomics In Precision Medicine: Application And Prospect In Cancer Research, Ming-Shi Shiao

Journal of Food and Drug Analysis

Metabolomics is the most recent and final discipline among the post-genomic, multiomics fields. It encompasses key technologies in systems biology, providing an overview of low-molecular-weight metabolites while examining disturbances to offer pathophysiological explanations. The two key analytical tools in metabolomics are nuclear magnetic resonance spectroscopy and mass spectrometry, which includes gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Metabolomic research relies on a three-stage data generation process: the first stage involves precise analytical chemistry to produce data; the second stage employs multivariate statistical analysis; and the last stage uses big data as a reference for comparison to establish biochemical, metabolic, and …

Mass Spectrometry-Based Metabolomics For Studying Gut Microbiota-Derived Metabolites In Biological Samples, Ya-Ting Lin, Huai-Hsuan Chiu, Chih-Ning Cheng, Ching-Hua Kuo

Journal of Food and Drug Analysis

Gut microbiota produces a wide range of metabolites and plays a critical role in maintaining host health. Dysregulation of these metabolites can influence host metabolism through systemic circulation, contributing to the development of various diseases, including immunological, neurological and cancer-related disorders. Chromatography coupled with mass spectrometry (MS) has emerged as a powerful analytical approach, offering high sensitivity and resolution for studying gut microbiota-related metabolites. This review provides a comprehensive overview of chromatographic MS-based methods applied to the study of the gut microbial metabolome. We summarize strategies for sample collection, storage, and preparation of commonly analyzed sample types, including feces, plasma/serum, …

Special Issue: Analytical Technologies In Metabolomics: Applications And Future Prospects, Sung-Fang Chen

Journal of Food and Drug Analysis

No abstract for this article type.

Perspective In Biomedical Sciences Field: Education And Career, Fitra Adi Prayogo, Mellyaning Oktaviani Sonya Kirana Sari, Isy Royhanaty, Poppy Fansisca Amelia, Heni Wijayanti, Ni Nyoman Maryaningtyas Adinatha, Dyah Wulandari, Anto Budiharjo

Chulalongkorn Medical Journal

Abstract

Background: The biomedical sciences represent a dynamic and multidisciplinary field pivotal to advancing human health through research, education, and innovation.

Objective(s): This review explores the evolving landscape of biomedical education and career pathways, driven by technological advancements, interdisciplinary integration, and global health demands.

Methods: We examine the distinctions between biomedical science, biomedicine, and biomedical engineering, highlighting their historical origins and contemporary roles. The education and career trajectories of biomedical laboratory scientists (BLS) are analysed, emphasising diverse competencies, core curricula, and the impact of regional policies on professional qualifications. Emerging trends and ethical/regulatory challenges are discussed.

Result(s): Key trends include …

Suture Augmentation With Ucl Repairs In Baseball Pitchers As An Alternate To Reconstructions: An Evidence-To-Practice Review, Kayleigh A. De Koker, Kenneth E. Games

Clinical Practice in Athletic Training

An injury to the ulnar collateral ligament (UCL) is sustained through repetitive valgus motions, increasing in prevalence across all levels of baseball due to the increasing workload demands placed on the medial elbow in pitching. Traditionally, UCL tears have been managed through reconstructions followed by a lengthy rehabilitation process. In recent years, the UCL repair with suture augmentation has gained favor given the enhanced patient and clinician outcomes in return-to-play timelines, decreased medial gapping, improved Kerlan Jobe Orthopedic Clinic (KJOC) scores, and long-term functionality. Utilizing 4 databases (MEDLINE, Embase Cochrane library, Science Direct, and Scopus), literature was obtained addressing the …

Optimal Control And Bifurcation Analysis Of A Predator–Prey Model With Self-Limiting Growth And Predator Disease, Dipo Aldila, Muhammad Akmal Fasya, Bevina D. Handari, Chidozie Williams Chukwu, Olumuyiwa James Peter

Mathematical Modelling and Numerical Simulation with Applications

We propose and analyze an eco-epidemiological predator–prey model that incorporates self-limitation and disease transmission within the predator population. The model is formulated as a system of ordinary differential equations describing logistic prey growth under the interspecific interaction with the predator. On the other hand, the predator population is divided into susceptible and infected classes, whose growth is constrained by prey availability. Three biologically relevant equilibria are identified: predator extinction, disease-free coexistence, and coexistence with endemic disease. The existence and stability of these equilibria are determined by key ecological and epidemiological thresholds, including the basic reproduction number. Using numerical continuation methods, …

Optimal Control Strategies For Infectious Diseases: A Numerical Simulation Approach, M. Abu Salek, Jannatun Nayeem, Romana Yesmin, M. Haider Ali Biswas, M. Humayun Kabir

Mathematical Modelling and Numerical Simulation with Applications

Various infectious diseases, such as Tuberculosis and Hepatitis B virus (HBV), caused by Mycobacterium bacteria and hepatitis B virus, respectively, pose serious threats worldwide. This paper examines the spread of these diseases using a mathematical model that incorporates control measures, including vaccination and awareness programs. We use a system of differential equations with control variables and apply Pontryagin's principle to determine optimal control strategies. The stability of the Disease Free Equilibrium (DFE) has been analysed and demonstrated to be both locally and globally asymptotically stable when the basic reproduction number remains below unity, thereby ensuring disease elimination. Furthermore, the Endemic …

Impact Of Tropical Cyclones On Food And Nutrition Security: A Global Scoping Review And Thematic Analysis, Patience M. Chiotha, Budi Haryanto

Jurnal Epidemiologi Kesehatan Indonesia

The increasing frequency and intensity of tropical cyclones driven by climate change pose growing threats to food and nutrition security. Globally, an estimated 80–90 tropical cyclones occur annually, affecting approximately 119 million people. Evidence regarding their impact on food systems, dietary patterns, and nutritional status remains fragmented. This scoping review aimed to map global evidence on the impacts of tropical cyclones on food and nutrition security, identify key pathways of impact, and examine affected indicators at household and individual levels. The review followed Joanna Briggs Institute guidelines and PRISMA-ScR. Searches were conducted in PubMed/MEDLINE, Web of Science, Scopus, and Google …

Risk Factors Of Leptospirosis Among Agricultural Workers In Southeast Asia: Literature Review, Ronggo Adi Wibowo, Wawa Najwa Nurzakia, Meirany Sasitha Kirana, Yulia Arthemisia Wijaya, Jasmine Ayumaharani Sekaryudha, Dwi Sarwani Sri Rejeki, Rosita Dwi Jayanti

Jurnal Epidemiologi Kesehatan Indonesia

The agricultural sector is the primary source of livelihood for communities in Southeast Asia; however, these activities increase the risk of exposure to zoonotic diseases, particularly leptospirosis. Southeast Asia is one of the regions with the highest incidence of leptospirosis in the world. This literature review aims to identify risk factors for leptospirosis among agricultural workers in Southeast Asia. The search for research articles utilized three databases (Google Scholar, PubMed, and ScienceDirect) using a descriptive approach based on literature review and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A total of 9,800 articles were screened for …

Factors Associated With Stunting Among Children Aged 6 – 59 Months Attending Integrated Health Post (Posyandu) In Selapajang And Kedaung Wetan Villages, Neglasari Sub-District, Tangerang City: A Matched Case-Control Study, Michael Alexander Solang, Joue Abraham Trixie, Gloria Semula, Tiona Simamora, Conny Tanjung

Jurnal Epidemiologi Kesehatan Indonesia

Stunting is a problem in Indonesia. In 2022, Kedaung Wetan and Selapajang Villages in Neglasari sub-district, Tangerang City, were identified as a priority. This study aimed to identify factors associated with stunting among children (6 – 59 months) in these villages. A matched case-control study consisting of 214 children (107 cases and 107 controls) was conducted, with individual matching based on age, sex, and prematurity at birth. Cases were children with height-for-age (H/A) measurement less than -2SD (according to WHO standard), while controls were children with H/A equal to or greater than -2SD. Conditional logistic regression was used for the …

Numerical Simulations And Hyers-Ulam Stability Of A Novel Nonlocal Anthropogenic Cutaneous Leishmaniasis Mathematical Model, Khalid Fanoukh Al Oweidi, Zakirullah -, Kamal Shah, Thabet Abdeljawad

Mathematical Modelling and Numerical Simulation with Applications

In this work, the fractal-fractional Atangana-Baleanu derivative with the Mittag-Leffler kernel is employed to capture the memory and hereditary effects inherent to anthropogenic cutaneous leishmaniasis transmission dynamics. The Banach fixed-point theorem and contraction mapping principle are used to prove the existence and uniqueness of solutions, while Hyers-Ulam stability of the system is analyzed to demonstrate the robustness of solutions with respect to small perturbations. Using a nonlinear least-squares approach, model parameters and fractional order are estimated using epidemiological data from the World Health Organization. The basic reproduction number $R_0 = 0.53$ indicates that the disease is under control after adding …

Dynamical Analysis And Optimal Control Of The Mpox Transmission Model With Stratified Susceptibility, Tuhfatul Janan, Fatmawati Fatmawati, Cicik Alfiniyah, Santi Martini, Dipo Aldila, Agus Hasan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a mathematical model of Mpox transmission that combines stratified susceptibility (low-risk and high-risk groups) with vaccinated and asymptomatically infected compartments. The analysis of the model begins with examining the well-posedness, boundedness, and nonnegativity conditions for the solutions. The local stabilities of the equilibria are examined through the Jacobian matrix and phase plane analysis, while the global stabilities are provided through Lyapunov functions. The estimated parameters are verified using epidemiological data on Mpox cases in the United States, with an MAPE of 2.20% and R_0 > 1, indicating that Mpox remains endemic. Sensitivity analysis indicates that the contact rate …

A Randomized Study Of Digital Versus Genetic Counselor Return Of Actionable Genetic Research Results To Biobank Participants (Respect3 Study), Anuja Rajendra Godbole, Elisabeth Wood, Brian Egleston, Lily Hoffman-Andrews, Sarah Brown, Sarah Howe, Sanjana Shastri, Rajia Mim, Justin Feng, Anjali Owens, Susan Domchek, Reed Pyeritz, Bryson Katona, Staci Kallish, Giorgio Sirugo, Joellen Weaver, Linda Fleisher, Kuang-Yi Wen, Elena Elkin, Katherine Nathanson, Daniel Rader, Angela Bradbury

Department of Medical Oncology Faculty Papers

BACKGROUND: There is consensus that research participants should be informed about plans for return of genetic research results. However, best practices for return of results in large biobank and cohort studies do not exist currently, and how best to communicate actionable genetic research results remains unclear. While having genetic counselors disclose these results may be ideal to ensure understanding, minimize distress, and optimize medical follow-up, genetic counselor (GC) workforce shortages and costs are barriers. The RESPECT3 study evaluates whether digital delivery alternatives for pre-disclosure education and return of actionable genetic research results is non-inferior to remote telehealth disclosure by a …