Digital Commons Network^™

Training Dual-Task Walking In Community-Dwelling Adults Within 1 Year Of Stroke: A Protocol For A Single-Blind Randomized Controlled Trial, Prudence Plummer-D'Amato, Anastasia Kyvelidou, Dagmar Sternad, Bijan Najafi, Raymond M. Villalobos, David Zurakowski

Journal Articles

No abstract provided.

Effect Of Game Activities On Manual Dexterity In Older Adults, Jael J. Hagerott

EWU Masters Thesis Collection

"The purpose of this study was to examine the effects of game activities on manual dexterity performance iri older adults. Seventeen participants (mean age 84.3 years) from local assisted- and independent-living retirement communities were randomly assigned to an experimental or control group. Experimental group participants played selected game activities three days per week for an average of 34.6 minutes per game for a six-week period. Both control and experimental group participants completed the Purdue Pegboard as a pre- and post-test assessment of manual dexterity performance. A 2 X 2 repeated measures mixed ANOVA conducted for each subtest of the Purdue …

Important Information Literacy Standards For Life And Health Sciences, Betsy S. Hopkins

Faculty Publications

Information literacy in the life and health sciences is a dynamic field, with challenges, opportunities, and rewards for the successful practitioner. This chapter will describe the big picture of information literacy in these disciplines, list relevant performance indicators from the ALA/ACRL/STS Task Force on Information Literacy for Science and Technology [STS-TFILST] (2006) Information Literacy Standards for Science and Technology (hereafter Standards), and give some practical advice for life and health sciences librarians and librarians with instructional responsibilities in those disciplines. The focus is on undergraduates at research universities, although many principles and strategies will apply to other circumstances.

Vitamin D Status, Adiposity, And Athletic Performance Measures In College-Aged Students, Laura Forney

LSU Master's Theses

Research suggests that elevated serum concentrations of 25-hydroxyvitamin D (25OHD) are associated with slowing the development of many age-related chronic diseases. Recent reports also show a positive relationship between 25OHD and muscle synthesis, strength, power and decreased body fat in elderly individuals. However, these findings have not been consistently reported in younger, healthy populations. PURPOSE: To investigate the relationship between 25OHD levels, body composition, measures of aerobic fitness and muscular strength and power in a young, physically active population. METHODS: Thirty-nine active subjects (20 males, 19 females; 23 ± 0.7 years old) reported to the lab six times for testing. …

C-Met Initiates Epithelial Scattering Through Transient Calcium Influxes And Nfat-Dependent Gene Transcription, Peter R. Langford

Theses and Dissertations

Hepatocyte growth factor (HGF) signaling drives epithelial cells to scatter by breaking cell-cell adhesions and migrating as solitary cells, a process that parallels epithelial-mesenchymal transition. HGF binds and activates the c-Met receptor tyrosine kinase, but downstream signaling required for scattering remains poorly defined. This study addresses this shortcoming in a number of ways.A high-throughput in vitro drug screen was employed to identify proteins necessary in this HGF-induced signaling. Cells were tested for reactivity to HGF stimulation in a Boyden chamber assay. This tactic yielded several small molecules that block HGF-induced scattering, including a calcium channel blocker. Patch clamping was used …

Effect Of Experimentally-Induced Anterior Knee Pain On Postural Control, Emily Elizabeth Falk

Theses and Dissertations

Context: Knee pain is experienced by many people. Because of this, authors have started researching the effects of pain on lower extremity mechanics and also on static and dynamic postural control. However, the effects of pain are difficult to study due to associated confounding variables. Objective: We asked: (1) Will experimentally-induced anterior knee pain alter perceived pain using the visual analogue scale? ; (2) will perceived pain affect postural control as measured by center-of-pressure during static and dynamic movement? Design: Crossover. Setting: Biomechanics laboratory. Participants: Fifteen healthy subjects. Intervention: Each subject participated in single leg quiet stance, landing, and walking …

Measuring Enjoyment Of Physical Activity In Older Adults: Invariance Of The Physical Activity Enjoyment Scale (Paces) Across Group And Time, Sean P. Mullen, Erin A. Olson, Siobhan M. Phillips, Amanda N. Szabo, Thomas R. Wójcicki, Emily L. Mailey, Neha P. Gothe, Jason T. Fanning, Arthur F. Kramer, Edward Mcauley

Kinesiology, Health and Sport Studies

The purpose of this study was to validate the Physical Activity Enjoyment Scale (PACES) in a sample of older adults. Participants within two different exercise groups were assessed at two time points, 6 months apart. Group and longitudinal invariance was established for a novel, 8-item version of the PACES. The shortened, psychometrically sound measure provides researchers and practitioners an expedited and reliable instrument for assessing the enjoyment of physical activity.

Schrödinger And Nietzsche On Life: The Eternal Recurrence Of The Same, Babette Babich

Working Papers

Schrödinger and Nietzsche on Life: The Eternal Recurrence of the Same

This essay explores Schrödinger’s reflections on measurement, consciousness, and personal identity. Schrödinger’s, What Is Life? is read together with Nietzsche’s own reflections on the same question, in his aphorism What is Life? together with Nietzsche’s teaching of the eternal return of the selfsame. Schrödinger’s own thinking is influenced as is Nietzsche’s by Schopenhauer but Schrödinger also has the Vedic tradition as this influenced Schopenhauer himself in view.

Changes In Life History Within An Individual's Lifetime, Eric J. Billman

Theses and Dissertations

A central goal of life history theory is to understand the selective factors that generate the diversity of reproductive patterns observed in nature. Within lifetime changes in reproductive investment will determine an organism's fitness; however, this area of life history theory has received less attention than comparisons among population that characterize life history traits as a single population mean. Reproductive allocation can be affected by multiple cues; the integration of these cues across an organism's lifetime generates the diversity in life history strategies observed in nature. Life history studies should examine the interacting effects of multiple cues on life history …

Systematically Controlling For The Influence Of Age, Sex, Hertz And Time Post-Whole-Body Vibration Exposure On Four Measures Of Physical Performance In Community-Dwelling Older Adults: A Randomized Cross-Over Study, Harold L. Merriman, C. Jayne Brahler, Kurt Jackson

Physical Therapy Faculty Publications

Though popular, there is little agreement on what whole-body vibration (WBV) parameters will optimize performance. This study aimed to clarify the effects of age, sex, hertz, and time on four physical function indicators in community-dwelling older adults (N = 32). Participants were exposed to 2 minutes WBV per session at either 2 Hz or 26 Hz, and outcome measures were recorded at 2-, 20-, and 40-minute post-WBV. Timed get-up-and-go and chair sit-and-reach performances improved post-WBV for both sexes, were significantly different between 2 Hz and 26 Hz treatments (P ≤ 0.05), and showed statistically significant interactions between age and gender …

Dysfunctional Play And Dopamine Physiology In The Fischer 344 Rat, Stephen M. Siviy, Cynthia A. Crawford, Garnik Akopian, John P. Walsh

Psychology Faculty Publications

Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain. In the present study, Fischer 344 rats were compared to the commonly used outbred Sprague-Dawley strain on several behavioral and physiological parameters in order to ascertain whether the lack of play may be related to compromised activity of brain dopamine (DA) systems. As expected, Fischer 344 rats were far less playful than Sprague-Dawley rats, with Fischer 344 rats less likely to initiate playful contacts with a playful partner and less likely to respond playfully to these …

The Genetic Influence On The Placebo Effect Specific To Exercise Performance, Jennifer Wu

Masters Theses, 2010-2019

Placebo treatments can be used to elicit many different physiological responses; however, the underlying mechanisms responsible remain unclear. Recent research has shown the possibility of a genetic influence on the placebo response in patients with mood disorders. In this study, we attempted to establish a similar relationship in healthy college-aged students. Force production was measured by isometric knee extension of the quadriceps muscles using maximum voluntary contractions (MVC). Subjects were given placebo treatments disguised as an undisclosed sports supplement with the information that the supplement was previously shown to provide immediate strength improvements following ingestion. Subject DNA was genotyped for …

A General Life History Theory For Effects Of Caloric Restriction On Health Maintenance, Chen Hou, Kendra Bolt, Aviv Bergman

Biological Sciences Faculty Research & Creative Works

Background: Caloric restriction (CR) has been shown to keep organisms in a relatively youthful and healthy state compared to ad libitum fed counterparts, as well as to extend the lifespan of a diverse set of organisms. Several attempts have been made to understand the underlying mechanisms from the viewpoint of energy tradeoffs in organisms' life histories. However, most models are based on assumptions which are difficult to justify, or are endowed with free-adjusting parameters whose biological relevancy is unclear.

Results: In this paper, we derive a general quantitative, predictive model based on physiological data for endotherms. We test the hypothesis …

Aging Is Associated With Positive Responding To Neutral Information But Reduced Recovery From Negative Information, Carien M. Van Reekum, Stacey M. Schaefer, Regina C. Lapate, Catherine J. Norris, Lawrence L. Greischar, Richard J. Davidson

Dartmouth Scholarship

Studies on aging and emotion suggest an increase in reported positive affect, a processing bias of positive over negative information, as well as increasingly adaptive regulation in response to negative events with advancing age. These findings imply that older individuals evaluate information differently, resulting in lowered reactivity to, and/or faster recovery from, negative information, while maintaining more positive responding to positive information. We examined this hypothesis in an ongoing study on Midlife in the US (MIDUS II) where emotional reactivity and recovery were assessed in a large number of respondents (N = 159) from a wide age range (36–84 …

Noise And Complexity In Human Postural Control: Interpreting The Different Estimations Of Entropy, Christopher K. Rhea, Tobin A. Silver, S. Lee Hong, Joong Hyun Ryu, Breanna E. Studenka, Charmayne M. L. Hughes, Jeffrey M. Haddad

Kinesiology and Health Science Faculty Publications

Background: Over the last two decades, various measures of entropy have been used to examine the complexity of human postural control. In general, entropy measures provide information regarding the health, stability and adaptability of the postural system that is not captured when using more traditional analytical techniques. The purpose of this study was to examine how noise, sampling frequency and time series length influence various measures of entropy when applied to human center of pressure (CoP) data, as well as in synthetic signals with known properties. Such a comparison is necessary to interpret data between and within studies that use …

Metabolic Restructuring During Energy-Limited States: Insights From Artemia Franciscana Embryos And Other Animals, Steven C. Hand, Michael A. Menze, Apu Borcar, Yuvraj Patil, Joseph A. Covi, Julie A. Reynolds, Mehmet Toner

Faculty Research & Creative Activity

Many life history stages of animals that experience environmental insults enter developmental arrested states that are characterized by reduced cellular proliferation, with or without a concurrent reduction in overall metabolism. In the case of the most profound metabolic arrest reported in invertebrates, i.e., anaerobic quiescence in Artemia franciscana embryos, acidification of the intracellular milieu is a major factor governing catabolic and anabolic downregulation. Release of ion gradients from intracellular compartments is the source for approximately 50% of the proton equivalents needed for the 1.5 unit acidification that is observed. Recovery from the metabolic arrest requires re-sequestration of the protons with …

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.

Eastern Ichigan University Graduate Catalog, 2011-2012, Office Of The Registrar

Graduate Catalogs

No abstract provided.

The Impact Of Infectious Disease On Chronic Disease: A Review Of Contemporary Findings, Wendy Bjerke

All PTHMS Faculty Publications

Infectious diseases are among the top causes of death in adults and children. Chronic diseases such as cardiovascular disease and cancer are among the top causes of death in adults. Associations between bacterial and viral infectious agents and subsequent development of chronic disease have been made in the past but are currently being reexamined with more rigor and specificity. This review examines infectious disease agent causes and associations with cancer, cardiovascular disease, metabolic disease, and neurodegenerative disease. These associations will impact future research, surveillance, treatment, and prevention of both infectious and chronic diseases.

Psychosocial Aspects Of Physical Activity And Fitness In Special-Population, Minority Middle School Children, Jeffrey J. Martin, Nate Mccaughtry, Anne S. Murphy, Sara Flory, Kimberlydawn Wisdom

Kinesiology, Health and Sport Studies

Special-population research predicting physical activity (PA) and fitness with minority middle school children from at-risk environments is rare. Hence, the purpose of our investigation was to evaluate the ability of important social cognitive and environment-based measures to predict PA and fitness with children with developmental delay, cognitive, and emotional impairments. Children (N = 89, ages 11-15) completed questionnaires assessing social cognitive and environment-based constructs, self report PA, and completed fitness testing. Correlational results supported some hypotheses. The descriptive and correlational results also indicated commonalities with similar research on non special-population minority middle school children from at-risk environments.

Increased Transsulfuration Mediates Longevity And Dietary Restriction In Drosophila, Hadise Kabil, Omer Kabil, Ruma Banerjee, Lawrence G. Harshman, Scott D. Pletcher

School of Biological Sciences: Faculty Publications

The mechanisms through which dietary restriction enhances health and longevity in diverse species are unclear. The transsulfuration pathway (TSP) is a highly conserved mechanism for metabolizing the sulfur-containing amino acids, methionine and cysteine. Here we show that Drosophila cystathionine β-synthase (dCBS), which catalyzes the rate-determining step in the TSP, is a positive regulator of lifespan in Drosophila and that the pathway is required for the effects of diet restriction on animal physiology and lifespan. dCBS activity was up-regulated in flies exposed to reduced nutrient conditions, and ubiquitous or neuron-specific transgenic overexpression of dCBS enhanced longevity in fully fed animals. Inhibition …

Body Mass Index Is Associated With Dietary Patterns And Health Conditions In Georgia Centenarians, Dorothy B. Hausman, Mary Ann Johnson, Adam Davey, Leonard W. Poon

Department of Nutrition and Health Sciences: Faculty Publications

Associations between body mass index (BMI) and dietary patterns and health conditions were explored in a population-based multiethnic sample of centenarians from northern Georgia. BMI ≤20 and ≥25 was prevalent in 30.9% and 25.3% of study participants, respectively. In a series of logistic regression analyses controlled for gender and place of residence, the probability of having BMI ≥25 was increased by being black versus white and having a low citrus fruit, noncitrus fruit, orange/yellow vegetable or total fruit and vegetable intake. The probability of having BMI ≤20 was not associated with dietary intake. When controlled for race, gender, residence, and …

Metabolic Restructuring During Energy-Limited States : Insights From Artemia Franciscana Embryos And Other Animals., Steven Hand, Michael Menze, Apu Borcar, Yuvraj Patil, Joseph Covi, Julie Reynolds, Mehmet Toner

Faculty and Staff Scholarship

Many life history stages of animals that experience environmental insults enter developmental arrested states that are characterized by reduced cellular proliferation, with or without a concurrent reduction in overall metabolism. In the case of the most profound metabolic arrest reported in invertebrates, i.e., anaerobic quiescence in Artemia franciscana embryos, acidification of the intracellular milieu is a major factor governing catabolic and anabolic downregulation. Release of ion gradients from intracellular compartments is the source for approximately 50% of the proton equivalents needed for the 1.5 unit acidification that is observed. Recovery from the metabolic arrest requires re-sequestration of the protons with …

The Effects Of Whole Body Vibration On Strength Gains In The Bench Press, The Back Squat, And The Power Clean In Division I Football Players, Kelly S. Poppinga

Theses and Dissertations

The purpose of this study was to determine if whole body vibration effects strength gains in the bench press, the back squat, and the power clean in division 1 football players. Thirty-one NCAA Division 1 male football players volunteered for this study and were randomly assigned to a control group (C=16) or one of two vibration groups (V1=7, V2=8). Subjects followed the training program for eight weeks. A pre-test, mid-test, and post-test one repetition max was measured at 0, 4, and 8 weeks for the bench press, the back squat, and the power clean. A 3x3 factorial ANOVA revealed varied …

The Influence Of Persistent Pathogens On Circulating Levels Of Inflammatory Markers: A Cross-Sectional Analysis From The Multi-Ethnic Study Of Atherosclerosis, Aydin Nazmi, Ana V. Diez-Roux, Nancy S. Jenny, Michael Y. Tsai, Moyses Szklo, Allison E. Aiello

Food Science and Nutrition

Background: Systemic inflammation is linked to cardiovascular risk, but the influence of persistent pathogens, which are conventionally dichotomously categorized, on circulating levels of inflammatory markers is not clear. Antibody levels of pathogens have not been examined in relation to inflammation.
Methods: Using data from a subsample of the Multi-Ethnic Study of Atherosclerosis, we examined circulating levels of interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen in relation to five common persistent pathogens: cytomegalovirus, herpes simplex virus-1, Hepatitis A virus, Helicobacter pylori and Chlamydia pneumoniae. We tested the hypothesis that the number of seropositive pathogens (based on conventional …

Response To Chastin Et Al.: Analysis Of Nonlinear Patterns Of Activity, James T. Cavanaugh, Nicholas Stergiou

Journal Articles

We appreciate the thoughtful commentary by Chastin and colleagues regarding our recent article entitled “Nonlinear Analysis of Ambulatory Activity Patterns in Community-dwelling Older Adults.” (1) We fully agree with their observation that the application of nonlinear analytical tools to accelerometry data is an emerging area of research that shows potential for illuminating the complex nature of physical activity profiles. We also welcome the opportunity to discuss their concerns regarding (a) our application of detrended fluctuation analysis (DFA), entropy rate, and approximate entropy to natural activity data and (b) our narrow focus on stepping activity.

The Effect Of Resistance Training On Strength And Total Physical Activity In Postpartum Females, Tiffany Kaye Hinman

Theses and Dissertations

The purpose of this study was to compare strength and physical activity (PA) changes in postpartum women randomly assigned to either a four-month progressive resistance training (RT) program or a four month flexibility program. Sixty healthy women between six weeks and eight months postpartum initiated the study and 43 completed the entire study. The women tended to be overweight, were all non-smokers, and most were breastfeeding (97%) at the beginning of the study. Both groups (RT and flexibility) completed training exercises twice weekly. Both groups improved in all measures of strength (RT group: leg press, P < 0.001; bench press, P < 0.001; curl-ups, P < 0.001. Flexibility group: leg press, P = 0.009; bench press, P < 0.001; curl-ups, P = 0.005); however, the RT group had higher strength gains compared to the flexibility group over time (leg press, P < 0.005; bench press, P < 0.001; curl-ups, P < 0.007). In addition, both groups increased in low back flexibility but the group*period interaction did not reach significance (P = 0.096). Light-intensity PA increased in the RT group but not the flexibility group (P < 0.05). A group*period interaction was significant for light-intensity PA time (P = 0.031) and borderline significant for sedentary time (P = 0.054). However, controlling for the number of months postpartum and weight gain during the previous pregnancy resulted in a significant interaction for sedentary time (P < 0.05). No changes were found in moderate, vigorous, or moderate to vigorous PA within or between groups over time. In conclusion, twice-weekly RT increases strength and is associated with improvements in several PA outcomes in postpartum women; however, the mechanisms for this are unclear. The training sessions and/or increased spontaneous activity may have contributed.

Longitudinal, Diet-Induced Weight Gain Is Associated With Increased Blood Monocytes And Reduced Tlr4 Expression, Kelley Strohacker, Richard J. Simpson, Katie C. Carpenter, Whitney L. Breslin, Brian K. Mcfarlin

International Journal of Exercise Science

Excessive weight gain increases systemic inflammation resulting in increased disease risk. Toll-like receptor 4 (TLR4) reportedly mediates increases in inflammation; however, its role has not been fully evaluated. Objective. The purpose of this study was to determine the longitudinal effect of diet-induced weight gain on blood monocyte concentration and cell-surface TLR4 expression. Research Methods & Procedures. Male CD-1 mice were randomly assigned to high-fat (HF, n = 12) or low-fat (LF, n = 13) groups. Non-lethal, saphenous vein blood samples were collected at 0, 4, 8 and 12 weeks of treatment. Three-color flow cytometry was used to measure monocyte (CD11b+/CD14+) …

Objective And Subjective Assessments Of ‘Normal’ Walking Pace, In Comparison With That Recommended For Moderate Intensity Physical Activity, Kathryn L. Taylor, Claire Fitzsimons, Nanette Mutrie

International Journal of Exercise Science

Abstract Despite its common application and widely reported health benefits, walking, in relation to pace and intensity, is under-researched. Few studies have addressed whether people normally walk at a pace which meets the public health recommendations for moderate intensity physical activity (1.34-1.79 ms-1) and there is no known research on individuals’ perceptions of factors which influence walking pace. This study aimed to objectively assess if participants were reaching the pace required for moderate intensity physical activity during ‘normal’ walking. This was examined via a Global Positioning System (GPS) over a 1 km outdoor walk and a timed 150 m trial. …