Digital Commons Network^™

Effects Of Serial Subtractions On Elderly Gait Speed In A Virtual Reality Setting, Taylor Leeder

UNO Student Research and Creative Activity Fair

Falls are the leading cause of fatal injuries in older adults aged 65+ with one in three adults falling each year. Cognitive processes are involved in gait, and thus, as cognitive changes are normative with age, this may impact fall risk in the elderly. Sixteen older adults aged 70.8±5.3 years took part in a dual-task (DT) study where they walked on a split-belt self-paced treadmill with and without a virtual reality (VR) setting while simultaneously performing a serial subtraction (SS) task. For SS, individuals were given a random 3-digit starting number and told to subtract by three from that number …

Hexapod Herald - Vol. 29, No. 2, March 2017

Hexapod Herald and Other Entomology Department Newsletters

Contents: Congratulations - Publications - Blasts from the Past - Grants - Faculty News - This 'n That - Meet an Online Student

The Association Of Serum Levels Of Brain-Derived Neurotrophic Factor With The Occurrence Of And Recovery From Delirium In Older Medical Inpatients, John Williams, Karen Finn, Vincent Melvin, David Meagher, Geraldine Mccarthy, Dimitrios Adamis

Department of Biological Sciences Publications

Limited studies of the association between BDNF levels and delirium have given inconclusive results. This prospective, longitudinal study examined the relationship between BDNF levels and the occurrence of and recovery from delirium. Participants were assessed twice weekly using MoCA, DRS-R98, and APACHE II scales. BDNF levels were estimated using an ELISA method. Delirium was defined with DRS-R98 (score > 16) and recovery from delirium as ≥2 consecutive assessments without delirium prior to discharge. We identified no difference in BDNF levels between those with and without delirium. Excluding those who never developed delirium (), we examined the association of BDNF levels and …

The Need For Standardized Assessment Of Muscle Quality In Skeletal Muscle Function Deficit And Other Aging-Related Muscle Dysfunctions: A Symposium Report, Rosaly Correa De Araujo, Michael O. Harris-Love, Iva Miljkovic, Maren Fragala, Brian Anthony, Todd Manini

Exercise and Nutrition Sciences Faculty Publications

A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other …

Are My Memory Changes Normal?, Maria Norton, Elizabeth B. Fauth

All Current Publications

This fact sheet discusses memory changes. As we age, our brains age right along with the rest of our bodies. Our reaction time may begin to slow as a result of aging, and we will continue to experience “mild forgetfulness” as a normal part of life. If your memory changes are greater, or these changes seem to be noticeably impacting your ability to carry on your normal day-to-day activities, these are indicators that it is time to be evaluated by a physician for MCI, dementia, or other cognitive problems. An accurate diagnosis of dementia will help you and your physician …

Mastoid Vibration Affects Dynamic Postural Control During Gait In Healthy Older Adults, Jung Hung Chien, Mukul Mukherjee, Jenny Kent, Nick Stergiou

Journal Articles

Vestibular disorders are difficult to diagnose early due to the lack of a systematic assessment. Our previous work has developed a reliable experimental design and the result shows promising results that vestibular sensory input while walking could be affected through mastoid vibration (MV) and changes are in the direction of motion. In the present paper, we wanted to extend this work to older adults and investigate how manipulating sensory input through mastoid vibration (MV) could affect dynamic postural control during walking. Three levels of MV (none, unilateral, and bilateral) applied via vibrating elements placed on the mastoid processes were combined …

Effects Of An Unusual Poison Identify A Lifespan Role For Topoisomerase 2 In Saccharomyces Cerevisiae, Gregory Tombline, Jonathan Millen, Bogdan Polevoda, Matan Rapaport, Bonnie Baxter, Michael Van Meter, Matthew Gilbertson, Joe Madrey, Gary A. Piazza, Lynn Rasmussen, Kirster Wennerberg, E. Lucile White, John L. Nitiss, David S. Goldfarb

Biology Faculty/Staff Publications

A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast) due to an inability to sense or repair DNA damage by topoisomerase 2 (yTop2). We describe the characterization of LS1, identified in a high throughput screen for small molecules that shorten the replicative lifespan of yeast. LS1 accelerates aging without affecting proliferative growth or viability. Genetic and biochemical criteria reveal LS1 to be a weak Top2 poison. Top2 poisons induce the accumulation of …

A Concept Analysis Of Resilience Integrating Genetics, Kosuke Niitsu, Julia F. Houfek, Cecilia R. Barron, Scott F. Stoltenberg, Kevin A. Kupzyk, Michael J. Rice

Department of Psychology: Faculty Publications

Although clinicians and researchers are interested in the phenomenon of resilience, there is no agreed-upon definition of resilience. Scientific evidence suggests that resilience is influenced by intrapersonal (e.g., personality traits) and environmental (e.g., social support) variables. A concept analysis was conducted to better understand the meaning of resilience. In this analysis, the antecedent of resilience was a potentially traumatic event; the defining attributes were ego-resiliency, emotion regulation, social support, and heredity; and the consequences were none to mild psychopathological symptoms and positive adaptation. This analysis can help nurses better understand resilience and its relationships …

The Relationship Between Sleep, Working Memory, And Decision Making In Young And Old Adult Populations, Melissa G. Merz

Honors Undergraduate Theses

Sleep is known to influence basic tasks concerning working memory, reaction time and executive functioning (Silva, Wang, Ronda, Wyatt, & Duffy, 2010; Nebes, Buysse, Halligan, Houck, & Monk, 2009). However, the amount that sleep influences these functions varies from study to study possibly due to differences in age and task design. Aim 1A of this study is to determine if sleep quality affects working memory. Aim 1B of this study is to determine if age affects sleep quality and working memory in comparison of young and old adult populations. Finally, Aim 2 of this study is to determine if there …

The Effects Of Unpredictable Food On Corticosterone And Social Learning In Red Crossbills (Loxia Curvirostra), Megan Catharine Wurtz

Senior Honors Theses and Projects

Foraging success can limit fitness if resources are unpredictable and strongly favor those that learn socially. Unpredictability can be a stressor and trigger elevations of stress hormones, that coordinate whole body responses to challenging environmental conditions. We explored the effects of unpredictable food on behavior, physiology, and receptiveness to social information using an observer/demonstrator paradigm in red crossbills, a highly social species that are adapted to cope with high degrees of resource unpredictability. Unpredictable food limited food intake (X²₁ = 10, p = 0.0012), caused a decline in body condition (X²₁ = 5.9, p …

Reliability And Minimum Detectable Change For Common Clinical Physical Function Tests In Sarcopenic Men And Women, Nathaniel D.M. Jenkins, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To determine the test–retest reliability and minimum detectable change scores for seven common clinical measurements of muscle strength and physical function in a multiethnic sample of sarcopenic, malnourished men and women.

Design: Each participant visited the laboratory seven times over 25 to 26 weeks. Reliability was assessed for each measurement from Familiarization 1 to Familiarization 2 (R1), Familiarization 2 to baseline testing (R2), Familiarization 3 to 12-week testing (R3), and Familiarization 4 to 24-week testing (R4).

Setting: Data were collected during a clinical trial at 23 sites in the United States, Belgium, Italy, Mexico, Poland, Spain, Switzerland, and the …

Changes In Postural Sway Behavior Across The Life Span, Maria M B N R Santos

Graduate Student Theses, Dissertations, & Professional Papers

The present study aimed to investigate human balance control by assessing postural sway on three groups representing three stages of life (6-12, 19-40 and 65-74 years old). There were 14 individuals in each group and they were tested during upright bipedal stance with either eyes open or closed. Focus was given to multiple sway indices representing multi-dimensional features of postural sway in quiet stance and included: the center of pressure area, amplitude, root mean square (RMS), velocity, jerkiness, and sample entropy. Results confirmed that children and seniors swayed more (p<.004), faster (p<.001) and their body sway was shakier (p<.001) than young adults. Seniors also presented faster (p<.006) and shakier (p<.001) sway than children and a more unpredictable pattern of body sway in time (p<.002) than children and young adults. In addition, children presented a more random anterior-posterior sway (p<.034) and a more regular medio-lateral sway (p<.043) than young adults, and a higher synchronization between anterior-posterior and medio-lateral body sway (p<.012) than young adults and seniors. We also observed that postural control of children and young adults becomes relatively more challenged in experimental situations when eyes were closed for most postural indices. In conclusion, this study suggests that multi-dimension posturography is sensitive to detect subtle age-related changes in the postural behavior and each stage of life may have their own signature patterns of postural behavior. Therefore, we expect that quantifications of this nature may be used to assess not only postural instability and fall risk but also to aid the testing of the efficacy of balance interventional protocols.

Quantification Of Brain-Region Specific Alterations In Insulin-Like Growth Factor-1 Expression During Developmental Hypothyroidism, Cari Lee Graber-Feesl

All Graduate Theses, Dissertations, and Other Capstone Projects

Insufficient thyroid hormone (TH) during development results in permanent neurological deficits. These deficits are the result of perturbed TH-mediated brain development. Interestingly, insufficient insulin-like growth factor 1 (Igf-1) during development results in neurological deficits that are similar to those reported for developmental hypothyroidism. This observation suggests that deficits associated with low TH during development may be the result of altered Igf-1 expression in the developing brain. To test this, timed-pregnant mice were treated with thyroid gland inhibitors from gestational day 16 (GD16) until postnatal day 21 (P21) to induce a hypothyroid state. A parallel set of untreated timed-pregnant mice were …

University Of Nebraska At Omaha 2017-2018 Course Catalog, University Of Nebraska At Omaha

Graduate Catalogs

The University of Nebraska Omaha (UNO) is a premier metropolitan university that combines the resources of a doctoral research institution with a thriving community in the heart of Omaha.

With a global reach and vision, UNO is large enough to provide opportunities students seek, yet personal enough to include the mentorship they need to achieve academic excellence, creativity, and engaged learningat competitive tuition rates.

UNO is committed to and engaged with the city surrounding it, allowing students unique hands-on opportunities, internships, service learning,applied research, and other collaborative activities that enhance time in the classroom.

This is the ”O” we want …

Riding Through Life: A Lifespan Study Of The Attitudes, Behaviors, And Areas Of Educational Opportunity For Female Equestrians Toward Bra Use And Health Outcomes When Engaged In Equestrian Sports, Karin Pekarchik

Theses and Dissertations--Community & Leadership Development

Equestrian sport is a popular exercise choice for females of all ages, although the links between this exercise choice, health outcomes, and risk to health have not been thoroughly examined. These issues are of particular interest because the female equestrian has the opportunity to ride and/or compete for decades, from early to very late in life, covering almost the full sequence of the female lifespan. Equestrian sports provide physical activity through riding and caring for the horse, and promote positive mental outcomes through tangible practices, such as engaging in physical activity and hard work, goal-setting, acquisition of skills, and participation …

Moderate-Load Muscular Endurance Strength Training Did Not Improve Peak Power Or Functional Capacity In Older Men And Women, Simon J. Walker, Greg G. Haff, Keijo K. Häkkinen, Robert U. Newton

Research outputs 2014 to 2021

The present study determined the effects of muscular endurance strength training on maximum strength and power, functional capacity, muscle activation and hypertrophy in older men and women. Eighty-one men and women acted as an intervention group while 22 acted as non-training controls (age range 64-75 y). Intervention training included super-sets (i.e., paired exercises, immediately performing the second exercises following completion of the first) with short rest intervals (30-60 s between sets) at an intensity of 50-60% one-repetition maximum (1-RM) for 15-20 repetitions. Concentric leg press actions measured maximum strength (1-RM) and concentric peak power. Functional capacity was assessed by maximum …

University Of Nebraska At Omaha Department Of Biomechanics Annual Report Spring 2017, Department Of Biomechanics, University Of Nebraska At Omaha

Biomechanics Annual Report

This report contains:

A letter from the Director: Dr. Nick Stergiou

Articles about Updates: Center for Research in Human Movement Variability

Articles about the Updates

Articles on Other Projects

Article about Beyond the Boarders

Articles on Outreach

and Highlights

The Effectiveness Of Environment Assessment Tools To Guide Refurbishment Of Australian Residential Aged Care Facilities: A Systematic Review, S Neylon, C Bulsara, A Hill

Health Sciences Papers and Journal Articles

Objective: To determine applicability of environment assessment tools in guiding minor refurbishments of Australian residential aged care facilities.

Method: Studies conducted in residential aged care settings using assessment tools which address the physical environment were eligible for inclusion in a systematic review. Given these studies are limited, tools which have not yet been utilised in research settings were also included. Tools were analysed using a critical appraisal screen.

Results: Forty-three publications met the inclusion criteria. Ten environment assessment tools were identified, of which four addressed all seven minor refurbishment domains of lighting, colour and contrast, sound, flooring, furniture, signage and …

Healthy Eating: How Do We Define It And Measure It? What’S The Evidence?, Christy C. Tangney, Beth A. Staffileno, Heather Rasmussen

Department of Nutrition and Health Sciences: Faculty Publications

A healthy diet can be defined in many ways, including defining one’s food intake by a dietary pattern. As described in the Dietary Guidelines for Americans Committee report, there are several defined dietary patterns associated with lower rates of chronic diseases. These include the Healthy Eating Index, Dietary Approach to Stop Hypertension, and those based on the Mediterranean diet. This review will focus on guiding health care professionals, including nurse practitioners, how a healthy diet pattern is defined, how it is measured, and a summary of recent evidence supporting the healthfulness of these dietary patterns.

Using Pentosidine And Hydroxyproline To Predict Age And Sex In An Avian Species, Brian S. Dorr, Randal S. Stahl, Katie C. Hanson-Dorr, Carol A. Furcolow

United States Department of Agriculture Wildlife Services: Staff Publications

All living organisms are subject to senescence accompanied by progressive and irreversible physiological changes. The error damage and cross-linking theories suggest that cells and tissues are damaged by an accumulation of cross-linked proteins, slowing down bodily processes and resulting in aging. A major category of these cross-linked proteins are compounds called advanced glycation end products (AGEs). We investigated the relationship between accumulation of the AGE, pentosidine (Ps), and hydroxyproline (HYP) a post-translationally modified amino acid, with age, sex, and breeding status (breeder/ nonbreeder) from skin samples of known age (i.e., banded as fledglings), free-ranging Double-crested Cormorants (Phalacrocorax auritus, …

Impact Of Staff Education On Geriatric Polypharmacy, Valerie Ikemefuna

Walden Dissertations and Doctoral Studies

Polypharmacy, the simultaneous use of multiple drugs to treat a single ailment or condition, is a

major health problem among the elderly population that contributes to adverse drug side events,

health risks, hospital readmissions, morbidity, and mortality. Therefore, a staff education

program geared toward reduction of such adverse drug events was implemented at a single site.

The purpose of the project was to determine if the staff education program would increase

knowledge of adverse drug events due to geriatric polypharmacy. The Orem theory provided the

theoretical support for the project, and the Iowa model guided the evidence-based practice

change process. …

Comparative Proteomic Analyses Of The Parietal Lobe From Rhesus Monkeys Fed A High-Fat/Sugar Diet With And Without Resveratrol Supplementation, Relative To A Healthy Diet: Insights Into The Roles Of Unhealthy Diets And Resveratrol On Function, Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, Govind Warrier, Kevin J. Pearson, Julie A. Mattison, Rafael De Cabo, Jian Cai, Jon B. Klein, D. Allan Butterfield

Chemistry Faculty Publications

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. …

Age Differences In Dynamic Fatigability And Variability Of Arm And Leg Muscles: Associations With Physical Function, Jonathon Senefeld, Tejin Yoon, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Introduction

It is not known whether the age-related increase in fatigability of fast dynamic contractions in lower limb muscles also occurs in upper limb muscles. We compared age-related fatigability and variability of maximal-effort repeated dynamic contractions in the knee extensor and elbow flexor muscles; and determined associations between fatigability, variability of velocity between contractions and functional performance.

Methods

35 young (16 males; 21.0 ± 2.6 years) and 32 old (18 males; 71.3 ± 6.2 years) adults performed a dynamic fatiguing task involving 90 maximal-effort, fast, concentric, isotonic contractions (1 contraction/3 s) with a load equivalent to 20% maximal voluntary isometric …

How Older Adults Would Like Falls Prevention Information Delivered: Fresh Insights From A World Cafe Forum, Linda Khong, Caroline Bulsara, Keith D. Hill, Anne-Marie Hill

IHR Papers and Journal Articles

Translation of falls prevention evidence into practice is problematic. Understanding older adults’ views about falls prevention information could enhance delivery of falls prevention, resulting in better engagement and uptake of recommended activities. The aim of this study was to examine the views and preferences of community-dwelling older adults about seeking and receiving falls prevention information. A community forum using a modified World Café approach was conducted. Participants discussed five topic areas in small groups, under the guidance of table facilitators. Perspectives were captured on paper. Thematic analysis was conducted to identify factors that influence participants’ engagement and uptake of information. …

The Effects Of Bicycling Exercise On The Metabolic Cost Of Walking In Older Adults, Daniel Hugo Aslan

Cal Poly Humboldt theses and projects

Impaired walking performance is a key determinant of morbidity among older adults. A distinctive characteristic of impaired walking performance among older adults is a greater metabolic cost compared to young adults. Specifically, healthy older adults have been shown to have a 15-20% greater metabolic cost of walking compared to young adults. However, a recent study suggests that older adults who routinely run for exercise have a lower metabolic cost of walking compared to older adults who walk for exercise. Yet, it remains unclear if other aerobic exercises such as bicycling elicits similar improvements on walking metabolic cost among older adults. …

Antioxidant Defenses In Three Vesper Bats(Chiroptera: Vespertilionidae) During Hibernation, Ekaterina Antonova, Viktor Ilyukha, Svetlana Sergina, Evgeniy Khizhkin, Vladimir Belkin, Alina Yakimova, Artem Morozov

Turkish Journal of Zoology

Hibernation of bats is characterized by considerable changes in the oxygen supply during the torpor-arousal cycles. The purpose of this study was to examine the antioxidant defenses in tissues of the hibernating bats ( Eptesicus nilssonii , Myotis brandtii , and Plecotus auritus ), attempting to relate the tissue antioxidant protection with the ecophysiological characteristics of the studied species. We found that the superoxide dismutase (SOD) activity in the heart and the catalase activity in the skeletal muscle were higher in E. nilssonii than in P. auritus and in M. brandtii. In comparison with studied hibernating bats, P. auritus had …

Task-Dependent Modulation Of Cortical Excitability And Balance Control In Individuals With Post-Concussion Syndrome, Kristen Kaster, Jayne M. Kalmar Ms., Michael E. Cinelli Mr

Theses and Dissertations (Comprehensive)

In most cases, symptoms resolve between 7-10 days post-concussion. However, in 10-15% of the concussed population, symptoms can remain unresolved for months to years following the head injury. The purpose of this thesis was two-fold, and was broken up into two studies, where the same individuals participated in both studies. The purpose of the first study was to quantify the differences in balance control between individuals with PCS (i.e., had been experiencing symptoms for <30 days) and non-concussed individuals during a lower-limb reaching task. Participants completed a static balance assessment before and after a lower-limb reaching task, which incorporated a Go/No-Go paradigm. Results from this study revealed no differences in the static stability assessments, however, individuals with PCS demonstrated increased medial-lateral COP displacement as well as greater trunk pitch during the reaching task. Overall, the findings reveal persistent balance impairments in individuals with PCS, which may put this population at an increased risk of further injury. The purpose of the second study was to assess task-dependent modulation of cortical excitability prior to planned index finger abduction contractions comparing a non-concussed population to a population with PCS. The protocol in this study consisted of both single and paired-pulse transcranial magnetic stimulation (TMS) which was applied prior to the beginning of 3 different tasks (i.e., a rest condition with no plan to contract, a precision contraction, and a powerful contraction). In addition to the three tasks, participants also had to respond to a Go/No-Go cue. The results of this study revealed an increase in excitability prior to a precision contraction in both non-concussed and PCS groups. No differences in task-dependent modulation were found between the two groups with respect to intracortical facilitation and inhibition, however a negative correlation between number of symptoms reported (SCAT3 symptom evaluation) and intracortical facilitation was revealed. The increase in corticospinal excitability prior to a precision contraction was not explained by the two cortical mechanisms we assessed and may therefore be due to spinal modulation or a different cortical mechanism. Overall, based on the results from this thesis, it appears that individuals with PCS have balance impairments, which may be a result of an inability to maximally activate their postural muscles. Furthermore, it appears that those individuals who reported a higher number of symptoms had greater reductions in intracortical facilitation, likely reflecting the heterogeneity of this clinical group.

Reliability Of Doming And Toe Flexion Testing To Quantify Foot Muscle Strength, Sarah T. Ridge, J. William Myrer, Mark T. Olsen, Kevin Jurgensmeier, A. Wayne Johnson

Faculty Publications

Quantifying the strength of the intrinsic foot muscles has been a challenge for clinicians and researchers. The reliable measurement of this strength is important in order to assess weakness, which may contribute to a variety of functional issues in the foot and lower leg, including plantar fasciitis and hallux valgus. This study reports 3 novel methods for measuring foot strength – doming (previously unmeasured), hallux flexion, and flexion of the lesser toes.

Changes In Mitochondrial Homeostasis And Redox Status In Astronauts Following Long Stays In Space, Hiroko P. Indo, Hideyuki J. Majima, Masahiro Terada, Shigeaki Suenaga, Kazuo Tomita, Shin Yamada, Akira Higashibata, Noriaki Ishioka, Takuro Kanekura, Ikuya Nonaka, Clare L. Hawkins, Michael J. Davies, Daret K. St Clair, Chiaki Mukai

Toxicology and Cancer Biology Faculty Publications

The effects of long-term exposure to extreme space conditions on astronauts were investigated by analyzing hair samples from ten astronauts who had spent six months on the International Space Station (ISS). Two samples were collected before, during and after their stays in the ISS; hereafter, referred to as Preflight, Inflight and Postflight, respectively. The ratios of mitochondrial (mt) to nuclear (n) DNA and mtRNA to nRNA were analyzed via quantitative PCR. The combined data of Preflight, Inflight and Postflight show a significant reduction in the mtDNA/nDNA in Inflight, and significant reductions in the mtRNA/nRNA ratios in both the Inflight and …

Dna Methylation Signatures Of Chronic Low-Grade Inflammation Are Associated With Complex Diseases, Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M. Mendelson, Karen N. Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L. Waite, Roby Joehanes, Weihua Guan, Jennifer A. Brody, Cathy Elks, Riccardo Marioni, Min A. Jhun, Golareh Agha, Jan Bressler, Cavin K. Ward-Caviness, Brian H. Chen, Tianxiao Huan, Kelly Bakulski, Elias L. Salfati, Whi-Empc Investigators, Giovanni Fiorito, Charge Epigenetics Of Coronary Heart Disease, Simone Wahl, Katharina Schramm, Jin Sha, Dena G. Hernandez, Allan C. Just, Jennifer A. Smith, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.

Results: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P < 1.15 × 10^–7) in the discovery panel …