Evaluation Of Circulating Hpg80, Ca15-3, Estrogen And Progesterone As Biomarkers In Breast Cancer Patients, Safa Khaldoon, Emad Yousif, Khawla A. Kasar, Muna Bufaroosha, Rahimi Yusop

AUIQ Complementary Biological System

It is very important to find reliable biomarkers for early detection and monitoring of treatment response because breast cancer is still one of the most common cancers in women around the world. The goal of this study was to find out how clinically important different biochemical markers are in Iraqi women with breast cancer. Some of these signs are progesterone (PG), oestrogen (E2), cancer antigen 15-3 (CA15-3), and circulating progastrin (hPG80). There were 100 women in this study, and they were all between the ages of 20 and 70. There were three groups of people who took part: a healthy …

Soft Systems For Community-Based Hcv Management In Indonesian Oil Palm Plantations, Neny Indriyana, Suyud Warno Utomo, Tri Edhi Budhi Soesilo, Linda Darmajanti

Journal of Environmental Science and Sustainable Development

Certification mandates under the Roundtable on Sustainable Palm Oil (RSPO) and Indonesian Sustainable Palm Oil (ISPO) have made measurable strides in promoting sustainability standards, yet governance challenges in High Conservation Value (HCV) 4, 5, and 6 management remain insufficiently addressed within Indonesian plantation contexts.  Drawing on adaptive governance theory and the social-ecological systems framework, this study argues that such gaps are structurally linked to the marginalisation of community agency within corporate-dominated decision-making. This study proposes and empirically evaluates an integrated governance framework that positions community engagement as a functional contributor to conservation outcomes within plantation landscapes of West Kalimantan, under …

Acute Effects Of Olympic Lifting Post-Activation Potentiation On Baseball Pitching Velocity And Ball Flight: A Crossover Study, Brent Hauser Pourciau

Doctoral Dissertations and Projects

This quantitative study evaluated the acute effect of an Olympic lifting-based post-activation potentiation (PAP) warm-up on fastball performance in collegiate baseball pitchers. Using a randomized, counterbalanced within-subjects crossover design (N = 13), each participant completed two warm-up conditions in a single indoor session: (a) a standard dynamic baseball warm-up and (b) the same standard warm-up followed by a brief Olympic-lifting PAP sequence (1 x 3 clean pulls at 80% predicted one-repetition maximum [1RM], 1 x 3 power cleans at 80% predicted 1RM, and 1 x 3 power jerks at 60% predicted 1RM, with 2-minute rests between sets) and a 3-minute …

A Case For Mtor Pathway Screening In Early Epilepsy Diagnosis, David Seamons

Student Works

Mutations in the mTOR pathway can give rise to epileptic seizures in patients. While a variety of antiepileptic drugs are available to treat epilepsy, a large proportion of patients will experience refractory seizures (Chen et al., 2018). Additionally, patients with mTOR-related epilepsy may experience reduced efficacy in traditional therapeutic options to treat seizures (French et al., 2016; Hadzsiev et al., 2023; Kato et al., 2022; Moloney et al., 2023). Mutations resulting in mTOR-related epilepsy are genetically inherited; however, some variability in family histories of epilepsy may be due to second-hit somatic mutations in focal areas of the brain (Dawson et …

Isolation, Identification And Antibiotic-Resistance Profiling Of Bacteria Isolated From Mobile Phone Surfaces In Karbala., Kawkab Abdullah Alsaadi, Zahraa Raheem Murshidy, Dhuha Ali Hussein, Sura Abd Ali Kadhim, Kawakib Aboudi Hanoon

Karbala International Journal of Modern Science

Due to the diverse environments that mobile phones are exposed to via human handling they become reservoirs of microorganisms. The objective of the current study was to determine the level and character of bacterial contamination on mobile phones by identifying bacterial strains, and the degree of antimicrobial susceptibility. A cross-sectional study was conducted from April to July 2025 where phones belonging to 115 individuals were randomly chosen from various departments and units at Kerbala University and swabbed. The VITEK 2 automated system was used to identify bacterial taxa and test for antimicrobial susceptibility, and 50 of the swabs exhibited bacterial …

Autoantibody Reactivity In Hidradenitis Suppurativa: Characterizing Keratinocyte And Apocrine Gland Targets Across Disease Progression And Anti-Tnf-Α Treatment, Talla Hamouche

Student Theses and Dissertations

Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease associated with impaired quality of life, representing one of the highest burdens among dermatological conditions. This debilitating disorder primarily affects apocrine-gland-bearing and flexural skin areas, most commonly the axillae, breast, buttocks, and groin. As lesions recur and new sites emerge, surgical excision does not guarantee prevention of disease reestablishment. Despite its substantial burden, HS remains among the least understood and most treatment-resistant inflammatory diseases. The mechanisms underlying this chronicity and the frequent failure of conventional anti-inflammatory therapies remain unresolved. An underappreciated autoimmune dimension may contribute to HS pathogenesis: the clonal …

Impacts Of Supplemental Fat In Finishing Diets On Digestibility, Performance, Carcass Outcomes, Meat Quality And Methane Production Of Feedlot Cattle, Anna Marie Kobza

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Rising costs and fluctuating availability of supplemental fats has led to increased interest in alternative fat sources or feed additives that might improve utilization of supplemental fat in feedlot diets. Two separate experiments were conducted to evaluate alternative strategies to overcome high fat prices. The first experiment was a metabolism study, conducted to evaluate digestion parameters of supplemental fat sources with or without LYSOFORTE Extend. The objectives of this experiment were to evaluate LYSOFORTE Extend in beef finishing diets containing a saturated fat source (tallow) and unsaturated fat source (corn oil). Duodenally and ruminally fistulated steers were fed diets containing …

Evaluation Of Sirna-Mediated Knockdown Of Heat Shock Protein 16.2 In Adult Acropora Cervicornis, Edward P. Gniffke, Benjamin D. Young, Keir J. Macartney, Michael S. Studivan, Ian C. Enochs, Erin E. Easton

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult corals that utilizes short interfering RNAs (siRNAs) and the RNA interference pathway. The Heat Shock Protein 16.2 (HSP16.2) gene in fragments of adult A. cervicornis was targeted for knockdown using a single siRNA construct. RT-qPCR analysis of HSP16.2 …

Investigating How Caffeine Affects Perceived Exertion And To What Extent Young Adults Consumers Are Aware Of The Active Ingredients, Brianna Richter

Honors Projects

BACKGROUND: Caffeine is one of the most widely consumed substances in the world, often used to increase energy and alertness. From morning coffee to pre-workout and energy drinks, caffeine has become a daily staple for students, athletes, and working professionals. In recent years, caffeine consumption has increased significantly, with the energy drink and pre-workout industries rapidly expanding. Research has been conducted on the effects of caffeine; however, there is limited research examining how consumer awareness of caffeine products and their additional active ingredients influence perceived exertion and exercise in young adults. PURPOSE: This study investigated the perceived effect of …

Eeg Studies Of Pre-Stimulus Activity During Turn-Taking In Naturalistic Conversation, Seyedmohamadreza Manzourolajdad

Student Works (2020-2029)

This study integrates conversational analysis principles and neural activity to investigate natural cognition and examine event-related brain changes. A wireless electroencephalography (EEG) device was used in an ecological validity setting to analyse pre-stimulus brain activity preceding conversational turns. This study aims to identify aspects of the conversation that reflect its naturalness in the aspect of listening and the corresponding brain activity by analysing the signals before and after a turn in a conversation. This research contributes to an ecologically valid understanding of natural conversation as a social action that enables seamless communication. Seven Malaysian participants (aged 19–22, M=20.46) engaged in …

The Impacts Of Wing-Flashing By Northern Mockingbirds On Foraging, Parental Care, And Reproductive Success, Anna Starman, Hayley Ponn

Science Seminar

Foraging efficiency may be enhanced by flashing patches of white wing and tail feathers and has been documented in several avian species. Northern Mockingbirds (Mimus polyglottos, NOMO) exhibit this "wing-flashing" (WF) behavior while foraging, during displays, and in response to predators. In NOMOs, WF has been hypothesized to increase foraging success, but previous findings are inconclusive. To further investigate the biological role(s) of WF behavior in NOMOs, the ventral surface of white primary feathers of male NOMOs were artificially darkened and the foraging and provisioning rates of undarkened (control) males and their mates were compared. While foraging, undarkened males performed …

Cost Analysis Formulation For Pv–Evcs–Dstatcom Integrated Distribution Systems Using Enhanced Hunter–Prey Optimization, Pappu Soundarya Lahari, Varaprasad Janamala

Mansoura Engineering Journal

With the rapid and significant growth of Electric Vehicles (EVs) and Distributed Generation (DGs), such as Photovoltaic (PV) deployment, in the distribution system, it is essential to address the challenges of rising power losses, voltage fluctuations, and reactive power imbalances. Optimal DSTATCOM placement in PV-EV integrated systems to mitigate power quality issues is an effective solution. It is thus necessary to evaluate the economic considerations of such heavily compensated networks. This study proposes Enhanced Hunter-Prey Optimization (EHPO) to assess the net savings of the PV-EVCS-DSTATCOM integrated IEEE-33,69, and 118 bus distribution networks in both single and multi-objective modes. The multi-objective …

Cultivating Curiosity Across Academic Audiences: Biology And Evidence-Based Science Communication, Nathan D. Forbes

Whittier Scholars Program

Effective Science Communicators must speak to a variety of audiences, with varying quantities of prior interest and qualities of background knowledge. The purpose of this paper was to engage differing audiences in scientific learning. This was done through a hypothetical newsletter made up for four different segments exploring a variety of topics in biology. Each segment intends to speak to a different audience with a different level of interest and/or educational level. Simplifying or analogizing without sacrificing the statistical basis of this project was of paramount importance. In the two segments targeted towards younger audiences, the primary focus was on …

Development Of A Preclinical Model That Can Be Used To Test Novel Therapeutics For The Treatment Of Mild And Moderate Traumatic Brain Injury, Hayden Anderson

Honors Theses

Traumatic Brain Injury (TBI) occurs when a foreign object induces damage to the skull and brain through a forceful blow or whiplash. It is one of the most frequent injuries in the United States, with approximately 250,000 cases of different levels occurring annually. It is well known that severe TBIs can result in persistent physical, cognitive, and socioeconomic consequences and the timing of treatment following this injury can play a critical role in the ultimate outcome. It would be beneficial to develop a safe therapeutic that could be administered rapidly after impact and improve the recovery of the patient. However, …

Role Of Rpm-1 In A C. Elegans Apoe4 Alzheimer’S Disease Model, Lucille Mcdonald

Biomedical Engineering and Sciences Student Publications

Alzheimer’s Disease (AD) is characterized by the aggregation of β-amyloid plaques. The ε4 allele of APOE (APOE4) is linked to increased plaque formation in AD. Therefore, identifying genetic modifiers of APOE4 could present novel drug targets for AD treatment.

Anterior Cruciate Ligament (Acl) Injuries In Female Athletes: Implications For Prevention And Rehabilitation, Natalie Amm

Honors Theses

Anterior cruciate ligament (ACL) injuries are among the most common lower limb injuries and pose significant physical, psychological, and long-term functional challenges for athletes. Additionally, research has suggested that females are up to eight times more likely to experience an ACL injury than their male counterparts. This increased risk is multifactorial with risks including anatomical structure, neuromuscular control, strength deficits, and hormonal fluctuations. However, the elevated risk of ACL injuries in female athletes may not solely be caused by biological differences, but also due to training programs and sports being designed around male athletes. This pushes us to change the …

Investigating The Synergistic Effects Of Mental And Physical Exhaustion On Learning And Attention In Emergency First Responders: An Eye-Tracking Study, Kayla Page

Electronic Theses and Dissertations

ABSTRACT

Exhaustion is known to impair cognitive functioning and performance, yet its effects on learning during video-based instruction among first responders and military service members remain underexplored. This study examined how mental, physical, and combined exhaustion independently influence learning outcomes and visual attention in a physically active sample drawn from military, public safety, and emergency service roles. Visual attention was measured utilizing eye tracking, focusing on fixation duration (FD) and fixation rate (FR). Participants completed instructional tasks under each exhaustion condition, allowing comparison of learning and gaze behavior across fatigue states. Results indicated that mental and physical exhaustion were associated …

Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen

Honors Thesis

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54^gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …

The Effects Of Oleuropein In Olive Leaf Extract Alone Or Combined With Calcitriol On The Viability And Migration Of Human Endometrial Cells In Vitro, Katelyn Devereaux

Electronic Theses and Dissertations 2020 - Present

Endometriosis is a chronic inflammatory disease affecting approximately 10% of reproductive-aged women worldwide and is commonly associated with pelvic pain, infertility, and reduced quality of life. Current management strategies, including hormonal therapies and surgical intervention, often provide only temporary relief and are associated with recurrence and adverse effects. These limitations highlight the need for alternative, non-hormonal therapeutic approaches that target underlying inflammatory and cellular mechanisms of disease progression.

This study evaluated the effects of oleuropein, contained within an olive leaf extract, and calcitriol, the active form of vitamin D, on cellular viability and migration in immortalized human endometriotic epithelial (12Z) …

​Functional Characterization Of Stmtpsl Terpene Synthase-Like Genes And Their Role In Pathogen Resistance In Selaginella Tamariscina, Zhijie He, Bo Bi

Turkish Journal of Agriculture and Forestry

The biological activity and function of microbial terpene synthase-like genes from Selaginella tamariscina (StMTPSL) were investigated using molecular and biochemical approaches. After isolating and amplifying StMTPSL genes (StMTPSL1-StMTPSL6), both native and site-directed mutant forms were expressed in tobacco via Agrobacterium-mediated transformation. The resulting transgenic plants had increased expression of StMTPSL genes, enhanced monoterpene production (as confirmed by GC-MS), and significantly improved resistance to Pseudomonas syringae infection compared to nontransgenic controls. These results show that StMTPSL genes are functionally active in plants and contribute to pathogen resistance through elevated terpene biosynthesis. This study provides new insights into the role of MTPSL …

Studies On The Contribution Of Osh6 To The Functions Of Late Endosomes, William King

Theses and Dissertations

The late endosome (LE) is a hub organelle connecting endocytic, biosynthetic, exocytotic, and autophagic vesicle traffic pathways. Malfunctions of LEs are associated with multiple age dependent diseases such as Parkinson’s disease (PD). Despite this significance, how cells refurbish lipids and proteins to LEs to maintain their sustained activities are not clear. Previous studies in the model organism budding yeast show that up-regulation of a lipid transporter Osh6 (PERG6-OSH6) accumulates phosphatidylinositol-4-phosphate (PI4P) on the trans-Golgi network. It also promotes vacuole fusion and maintains the robustness of vacuoles in aged cells. Since LEs are the organelle between the TGN and vacuoles in …

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …

Deep Learning Technology In Multimodal Remote Sensing Data Fusion To Analyze Crop Growth And Economic Forecast, Tianlong Jiang, Ziyang Liu, Li Sun

Turkish Journal of Agriculture and Forestry

This paper integrated multimodal remote sensing (RS) data with deep learning to develop a maize growth analysis and income prediction model based on CNN (Convolutional Neural Network)-Attention and Bi-LSTM (Bidirectional Long Short-Term Memory). Utilsing Landsat 8, Sentinel-2, and Sentinel-1 satellite data, the CNN-Attention network extracts vegetation features such as NDVI (Normalised Difference Vegetation Index), EVI (Enhanced Vegetation Index), and canopy density for corn growth stage identification and prediction. The study combined these features with meteorological, soil, and market data and fed them into a Bi-LSTM model for time series analysis to forecast corn income. The method achieved 98.3% accuracy in …

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …

Biomechanical Effects Of Bilateral Torsion And Skeletal Fusion: A Case Study, Linnéa Forbes

Honors Projects

As part of both a personal endeavor and an academic project, I have investigated the aetiology and treatment of seemingly idiopathic and debilitating leg pain in a patient over the past 10 years. Via collaboration with medical professionals at Cincinnati Children’s Hospital, Cincinnati Premier Physical Therapy, and Cincinnati Women’s TriHealth, I have identified sources of pain at the anatomical level. The combination of internal femoral torsion, external tibial torsion, pes planus, and bony fusions appear to be major perpetuators of the pain. An effective treatment continues to be evasive. To date, I have attempted to find answers through genetic approaches, …

Quantifying Sleep Wake Rhythms In The Hospital Environment With Digital Technologies, Carsten Skarke, Nadim El Jamal, Michael V. Genuardi, Thomas G. Brooks, Antonijo Mrčela, Nicholas F. Lahens, Makayla Cordoza, Sean Sarles, Amarachi Mbadugha, Dineth R. Karunamuni, Shikhar Gupta, Charles J. Bae, Amita Sehgal, Thomas P. Cappola, Jacob T. Gutsche, Pavan Atluri, Nimesh D. Desai, Michael A. Acker, Gregory R. Grant, Richard J. Schwab, Ilene M. Rosen, Garret A. Fitzgerald

Division of Cardiology Faculty Papers

Postoperative clinical care is prone to circadian desynchronization that may influence health outcomes. In an exploratory, feasibility-oriented and signal-exploration effort, we collected 1.8 million data points using 11 remote sensors during preoperative, in-hospital and post-discharge settings in 13 elective cardiac surgery patients (5.2% enrolled from 252 screened). We found that room traffic continued during nighttime with ≥1 visit/h. Sound levels exceeded the recommended 45 dBA threshold (51.9 ± 3.3 vs. 48.3 ± 4.2 dBA during nighttime). Brightness dropped at night (89.9 ± 87.7 to 3.7 ± 9.8 lux), but bright light exposures occurred. Ambient room temperature lacked sleep-inducing diurnal variability. …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Development And Validation Of Kinetics And Musculoskeletal Modeling For The Milwaukee Foot Model, Maxine L. Olson

Dissertations (1934 -)

Many children are afflicted by foot and ankle pathologies which affect the ankle, midfoot, and metatarsophalangeal joints. However, a clinically feasible foot model capable of assessing multi-segment kinetics throughout the gait cycle does not exist. Similarly, a musculoskeletal foot model utilizing multiple ground reaction forces (GRF) and Milwaukee Foot Model (MFM) kinematics has not been created. The purpose of this study was to develop a clinically feasible method of modeling multi-segment foot properties without increased clinician and/or patient burden or expense. To this end, a force distribution algorithm (FDA) was created, allowing for calculation of multi-segment foot kinetics, musculoskeletal modeling, …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

Analysis Of Agricultural Remote Sensing Data Driven By Artificial Intelligence On Crop Growth Patterns And Economic Benefits Of Grain, Yang Wang

Turkish Journal of Agriculture and Forestry

To address the shortcomings of conventional agricultural statistical and monitoring methods on a regional scale, this paper proposes the use of artificial intelligence-driven remote sensing data for analysing crop growth patterns and the economic benefits of grain. Winter wheat data from three stations in a single province from 2011 to 2020 was used, with the leaf area index (LAI) used as the key crop growth indicator value. The simulated annealing algorithm was used to assimilate the LAI and remote sensing leaf area index (MODIS-LAI), simulated by the World Food Study (WOFOST) simulation model, to carry out simulation analysis of winter …