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Articles 2371 - 2400 of 59127
Full-Text Articles in Entire DC Network
The Effects Of Off-Season Evidence-Based Training Block Periodization Program On The Performance Of Soccer Athletes In A Di School: An Exploratory Study, Ibrahim F. Almughathawi
The Effects Of Off-Season Evidence-Based Training Block Periodization Program On The Performance Of Soccer Athletes In A Di School: An Exploratory Study, Ibrahim F. Almughathawi
Electronic Theses and Dissertations
The investigators explored the effects of a two-year evidence-based block periodization strength training program on performance outcomes in NCAA Division I male soccer athletes. The investigators aimed to examine longitudinal changes in body composition, explosive strength, and match-play physical demands, as well as the associations between field-based performance assessment and GPS-derived metrics. Using a retrospective design, data were drawn from a research data repository for athletes who participated in a long-term sport science monitoring program under the same head coach and training conditions. Performance measures included vertical jump assessments (static and counter movement jumps under bodyweight and external load), isometric …
Trophic Roles And Climate-Driven Vulnerability For Benthic Invertebrates At Artificial Reefs In The Northern Gulf Of Mexico, Amanda Kirkland
Trophic Roles And Climate-Driven Vulnerability For Benthic Invertebrates At Artificial Reefs In The Northern Gulf Of Mexico, Amanda Kirkland
LSU New Orleans Theses and Dissertations
Artificial reefs are deployed to enhance marine habitats and fisheries, yet their role in supporting secondary production and their vulnerability to climate stressors remain understudied. This dissertation investigates the trophic ecology and climate sensitivity of benthic invertebrates at artificial reefs in the northern Gulf of Mexico. Chapter 1 assessed reef food webs using stable isotopes from fishes, invertebrates, and primary producers across six reefs and two seasons. Mixing models showed that most fishes rely on benthic reef carbon, while suspension feeders consume plankton and sediment microphytobenthos. Isotopic niche analysis revealed functional diversity and seasonal shifts in δ¹³C and δ³⁴S, though …
Saliva & Circadian Rhythm In Medical Profiling For Early Disease Prevention, Joseph Lewis
Saliva & Circadian Rhythm In Medical Profiling For Early Disease Prevention, Joseph Lewis
Graduate Student Dissertations, Theses, Capstones, and Portfolios
Circadian rhythms affect almost every biological process from hormone secretion, gene expression, immune regulation, and metabolism. Studies show that disruption to these internal rhythms through irregular sleep, artificial sleep, and irregular sleep can significantly increase risk for chronic disease such as diabetes, cardiovascular disorders, neurodegeneration, and cancer. Saliva presents a viable alternative for capturing biomarkers found through blood or cerebrospinal fluid, offering substantial utility for diagnostic and chronobiological profiling. Saliva contains hormones such as cortisol and melatonin while containing inflammatory markers that fluctuate rhythmically throughout the day. Due to its ease of collection, saliva is well suited for longitudinal monitoring, …
Insights Gained From Applying Molecular Techniques To Gray Triggerfish (Balistes Capriscus Gmelin, 1789) In The Mexican Caribbean, The Southern And Northwestern Gulf Of Mexico, Geaceli G. Orive
Theses and Dissertations
This study focuses on Balistes capriscus (Gray Triggerfish), a reef-associated species dependent on hard-bottom habitats in the Gulf of Mexico (GOM). Using mitochondrial DNA barcoding and phylogenetic analyses, genetic structure across four sites was assessed: Rio Grande Valley (RGV), Veracruz, Chinchorro Bank, and Xahuayxol. Samples from RGV and Veracruz exhibited limited haplotype diversity, minimal nucleotide divergence, and weak genetic differentiation-patterns consistent with recent population expansion and ongoing connectivity within the GOM. While the study centered on B. capriscus, all individuals from Chinchorro and Xahuayxol unexpectedly grouped with Canthidermis maculata (Spotted Oceanic Triggerfish), suggesting misidentification, cryptic diversity, or taxonomic uncertainty in …
Plant Nutrient Interactions In High-Yielding Soybean Environments, Victoria Inklman
Plant Nutrient Interactions In High-Yielding Soybean Environments, Victoria Inklman
Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research
Plant nutrient demands and limitations are usually studied individually by nutrient. Here, we investigated how nitrogen (N) limitation in high-yielding soybean environments affects the uptake, removal, and residual of other plant macro- and micronutrients. The objective of this study was to quantify the uptake, removal, and residual levels of soybean macro- and micronutrients under N-limited conditions and to identify nutrient priorities for high-yielding soybean systems. Aboveground plant samples at physiological maturity were collected in 19 high-yielding soybean fields with N limitation across the state of Nebraska. Reference plots with ample N supply were included within each field to compare macro- …
Linked Lives In The Riverbed: Integrating Fish Host Dynamics, Community Structure, And Demography For Freshwater Mussel Conservation., Jonathan Patrick Frommeyer
Linked Lives In The Riverbed: Integrating Fish Host Dynamics, Community Structure, And Demography For Freshwater Mussel Conservation., Jonathan Patrick Frommeyer
Electronic Theses and Dissertations
Freshwater mussels are long-lived benthic invertebrates that play key roles in nutrient cycling, water filtration, and habitat stability in rivers and streams. Despite their ecological importance, they are among the most imperiled faunal groups in North America, with their persistence increasingly threatened by environmental degradation and disruptions to host–parasite dynamics. This dissertation integrates host ecology, community structure, and demographic modeling to assess population viability and guide conservation priorities for mussel species in Kentucky river systems. The first chapter introduces the ecological context and conservation urgency surrounding freshwater mussels. In particular, emphasizing the need for multi-scale approaches to understand how parasitic …
Genes That Matter: Survival Modeling In Tcga-Brca With Treatment Interactions., David Pratt
Genes That Matter: Survival Modeling In Tcga-Brca With Treatment Interactions., David Pratt
Electronic Theses and Dissertations
High-dimensional genomic data offer both promise and challenges for identifying clinically relevant biomarkers. This study developed a parallelized survival modeling pipeline to identify genes associated with overall survival in breast cancer, with a focus on gene-by-treatment interactions and patient heterogeneity. RNA-Seq data from female patients in the TCGA-BRCA cohort were analyzed. Univariate Cox proportional hazards models were used to screen genes, adjusting for age, race/ethnicity, treatment status, and cancer stage. A LASSO-penalized Cox regression was fit across 2000 random seeds to assess feature stability. Genes were filtered by expression level, statistical significance, and hazard ratios (effect sizes) in either direction, …
Evaluating Maternal Polar Bear Denning Habitat Along The Arctic Coastal Plain And Assessing The Potential For Noise Disturbance In Polar Bear Dens, Ethan Ducharme
All Graduate Theses and Dissertations, Fall 2023 to Present
Polar bears (Ursus Maritimus) in northern Alaska are increasingly choosing land instead of sea ice to build their maternity dens. As sea ice continues to decline due to climate change, this shift makes it more important than ever to identify and protect the areas where polar bears dig dens to give birth and raise their cubs. In the first part of my research, I used new satellite-based elevation data to map potential polar bear denning habitat across a large section of Alaska’s Arctic Coastal Plain. This technology allowed me to identify the types of sloped terrain where drifting …
Evaluation Of Novel Biomarkers As Predictive Measures Of Mastitis – Establishing A Relationship With Health Status, Lamb Performance, And Determination Of Prevalence Of Mastitis In Ewes Under Intensive Management, Courtney Berghoff
All Graduate Theses and Dissertations, Fall 2023 to Present
Inflammation of the mammary gland, also known as mastitis, is a prevalent and financially impactful disease in sheep production. The objectives of this survey were to 1) evaluate current testing methods: somatic cell count (SCC), California Mastitis Test (CMT), and bacterial culture, as well as novel biomarkers: lamb performance, milk composition, and udder conformation, for their impact on ewes categorized as clinically healthy or unhealthy under intensive management systems at 15 days in milk (DIM) and 30 DIM, and 2) identify biological markers that are correlated with clinical and subclinical mastitis. Milk, blood, and fecal samples, a visual and physical …
What’S The Beef With Agriculture? Evaluating The Effectiveness Of An Agricultural Literacy Intervention On Students’ Attitudes And Knowledge Toward Sustainability And Animal Agriculture, Jenny E. Bennett
All Graduate Theses and Dissertations, Fall 2023 to Present
Agricultural literacy is essential for helping individuals understand how food systems impact their daily lives and society. While most research has focused on students’ knowledge, this study addresses the underexplored role of attitudes—critical predictors of behavior—as outcomes of educational interventions. This research analyzed survey data collected before and after an agricultural literacy intervention delivered to high school students in school-based agricultural education (SBAE) programs. The curriculum focused on sustainability in animal agriculture.
Findings from paired samples t-tests showed statistically significant improvements in students' attitudes (from moderately neutral to more positive) and knowledge scores. Further analyses revealed that demographic factors such …
Electrophysiological Markers Of Emotion Dysregulation In Autistic Youth, Rachel G. Mcdonald
Electrophysiological Markers Of Emotion Dysregulation In Autistic Youth, Rachel G. Mcdonald
Theses, Dissertations and Culminating Projects
Emotion dysregulation (ED) is a transdiagnostic mechanism that is conceptualized as difficultly regulating emotions and deploying appropriate regulation strategies in response to environmental stimuli. Meta-analyses suggest that autistic people, across the lifespan, experience more severe ED as compared to both neurotypical people and those with mental health conditions. Despite elevated risk and evidence linking ED to disruptions in neural mechanisms, no studies to date have examined neural markers of ED in autistic populations. The current project uses multi-method and multi-informant measurement to examine similarities and differences in neural mechanisms of ED in autistic and non-autistic populations. Forty-four youth aged 11—17 …
Examining The Use Of Two-Dimensional Video Capture And A Pressure Sensing Walkway For Collection Of Obstacle Crossing Measures, Ashlyn M. Jendro
Examining The Use Of Two-Dimensional Video Capture And A Pressure Sensing Walkway For Collection Of Obstacle Crossing Measures, Ashlyn M. Jendro
Graduate Theses and Dissertations
Obstacle crossing research is crucial for providing insights into how and why people trip and fall. However, a growing body of literature has proposed that laboratory-based studies may not directly translate into real-world settings due to the complex nature beyond the sterile lab. Unfortunately, the absence of real-world obstacle crossing literature is likely due to a lack of available validated methods for collection of data outside the laboratory. This dissertation explored two potential methodologies (i.e., 2D motion capture and a pressure sensing walkway) that are more portable and cost-effective for collecting real-world obstacle crossing measures. It is hypothesized that 2D …
Freezing And Shipping Optimization To Increase Quality And Profitability Of Meat E-Commerce, Paul Olaoluwaniyi Dahunsi
Freezing And Shipping Optimization To Increase Quality And Profitability Of Meat E-Commerce, Paul Olaoluwaniyi Dahunsi
Graduate Theses and Dissertations
Freezing remains one of the most reliable methods for preserving meat quality and extending shelf life. However, quality deterioration can still occur due to structural and biochemical changes activated during freezing, thawing, and distribution. Since the COVID-19 pandemic, consumers’ preference for bulk purchasing and online meat shopping has increased, raising questions about the best strategies to balance both quality maintenance and profitability. This thesis aimed to evaluate two key stages where frozen beef is most vulnerable to quality degradation: consumer-level freezing and post-purchase shipping. The objectives were (1) to determine the effects of product size and subsequent consumer freezing practices …
Effect Of Dietary Tryptophan Supplementation And Heat Stress On Pasture Broiler Welfare And Performance, Jaelen Matthew Cherry
Effect Of Dietary Tryptophan Supplementation And Heat Stress On Pasture Broiler Welfare And Performance, Jaelen Matthew Cherry
Graduate Theses and Dissertations
Pasture-raised broiler chickens face temperature extremes that can threaten welfare. In the study, we evaluated whether a 0.26 % tryptophan-supplemented diet (T) improved heat stress (HS) resilience in Ross-708 broilers raised on pasture. At D14, birds began the T or remained on the control diet (C) and were moved outdoors. On D20 and 41, half of each group underwent six-hour HS; the remainder stayed under thermoneutral (TN) conditions. Weekly body weight, feed intake on D20 and D41 were recorded, and fear was measured using the Tonic Immobility (TI) test. Neither diet nor HS affected body weight. However, tryptophan supplementation resulted …
Systematics Of African River Frogs (Anura: Pyxicephalidae: Amietia) In Central Africa, With The Description Of Two New Species, Jesus Manuel Reyes
Systematics Of African River Frogs (Anura: Pyxicephalidae: Amietia) In Central Africa, With The Description Of Two New Species, Jesus Manuel Reyes
Open Access Theses & Dissertations
Amietia is a pyxicephalid anuran genus that is prevalent throughout central, southern, and eastern portions of sub-Saharan Africa. Recent phylogenetic studies have been in conflict regarding the validity and composition of several Amietia species in the Albertine Rift region. The goals of this study are to: (1) generate an updated molecular phylogeny for Central African Amietia with new sampling; (2) clarify the relationship between the previously unsampled taxa A. amieti and A. chapini; (3) clarify the status of A. desaegeri; and (4) confirm the taxonomic status of potentially new species. Maximum likelihood and Bayesian inference methods were used to generate …
Phylogenetics And Integrative Taxonomy Of The Lang's Reed Frog Species Complex (Anura: Hyperoliidae: Hyperolius Langi), Dominic Troiani
Phylogenetics And Integrative Taxonomy Of The Lang's Reed Frog Species Complex (Anura: Hyperoliidae: Hyperolius Langi), Dominic Troiani
Open Access Theses & Dissertations
The genus Hyperolius (Rapp, 1842) is the most speciose amphibian genus in sub-Saharan Africa. The genus has a complex taxonomic history because of its extensive intraspecific and interspecific morphological variation, large geographic distribution of many taxa, gaps in sampling, and the discovery of significant cryptic diversity within many species. The goal of this study is to understand the relationships and taxonomy of Hyperolius langi via an integrative taxonomic approach that combines molecular, morphological, and bioacoustics data to clarify the systematics of the geographically widespread species Hyperolius langi. Two mitochondrial (16S and cyt b) and one nuclear (RAG1) gene were used …
Application Of Artificial Neural Network Algorithms For Irrigation Scheduling, Lisa Umutoni
Application Of Artificial Neural Network Algorithms For Irrigation Scheduling, Lisa Umutoni
All Dissertations
Neural networks have been extensively used in predicting soil water tension for improved irrigation scheduling and management. However, their lack of interpretability constrains their efficacy in grasping the nuanced patterns prevalent in soil water tension time series data. The first goal of this research was to develop interpretable deep neural network models for soil water tension prediction across multiple soil depths (0.15m, 0.3m, 0.46m and 0.6m) and prediction horizons (1h, 6h, and 12h). The Neural Hierarchical Interpolation for Time Series (N-HiTS) and Neural Basis Expansion Analysis Time Series (N-BEATS) models were used in this research. Historical soil water tension data …
Ppp2r1a Mutations Portend Improved Survival After Cancer Immunotherapy, Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M Hinchcliff, Annalyn Welp, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R Tyler Hillman, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Larissa A Meyer, David M Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A Jazaeri
Ppp2r1a Mutations Portend Improved Survival After Cancer Immunotherapy, Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M Hinchcliff, Annalyn Welp, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R Tyler Hillman, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Larissa A Meyer, David M Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A Jazaeri
Faculty, Staff and Student Publications
Immune checkpoint blockade (ICB) therapy is effective against many cancers, although resistance remains a major issue and new strategies are needed to improve clinical outcomes1-5. Here we studied ICB response in a cohort of patients with ovarian clear cell carcinoma-a cancer type that poses considerable clinical challenges and lacks effective therapies6-8. We observed significantly prolonged overall survival and progression-free survival in patients with tumours with PPP2R1A mutations. Importantly, our findings were validated in additional ICB-treated patient cohorts across multiple cancer types. Translational analyses from tumour biopsies demonstrated enhanced IFNγ signalling, and the presence of tertiary lymphoid structures at the baseline, …
Development Of A Multi-Institutional Dataset To Validate A Novel Inflammatory Breast Cancer Diagnostic Score, Filipa Lynce, Samuel M Niman, Megumi Kai, Sean Ryan, Elizabeth Troll, Kathy D Miller, Ginny Mason, Beth A Overmoyer, H T Carisa Le-Petross, Faina Nakhlis, Savitri Krishnamurthy, Beth T Harrison, Susie X Sun, Eren D Yeh, Jennifer R Bellon, Laura E Warren, Michael C Stauder, Meredith M Regan, Wendy A Woodward
Development Of A Multi-Institutional Dataset To Validate A Novel Inflammatory Breast Cancer Diagnostic Score, Filipa Lynce, Samuel M Niman, Megumi Kai, Sean Ryan, Elizabeth Troll, Kathy D Miller, Ginny Mason, Beth A Overmoyer, H T Carisa Le-Petross, Faina Nakhlis, Savitri Krishnamurthy, Beth T Harrison, Susie X Sun, Eren D Yeh, Jennifer R Bellon, Laura E Warren, Michael C Stauder, Meredith M Regan, Wendy A Woodward
Faculty, Staff and Student Publications
Background: Susan G. Komen, the Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened patient advocates, clinicians, and researchers to propose novel quantitative scoring rubrics for IBC diagnosis. In this study, we developed a multi-institutional clinical dataset to test and validate the proposed scoring system.
Methods: IBC (N = 988) and non-IBC (N = 332) cases were identified at 2 institutions with dedicated multidisciplinary IBC programs. The non-IBC cohort included consecutive cT4b and cT4c patients. Standard operating procedures (SOPs) were developed for all ambiguous findings and languages. Three different methods were used for the imputation of missing data, …
Author Correction: The Long-Term Effects Of Chemotherapy On Normal Blood Cells, Emily Mitchell, My H Pham, Anna Clay, Rashesh Sanghvi, Nicholas Williams, Joanne I Hsu, Hyunchul Jung, Aditi Vedi, Sarah Moody, Jingwei Wang, Daniel Leonganmornlert, Michael Spencer Chapman, Ellie Dunstone, Anna Santarsieri, Alex Cagan, Heather E Machado, E Joanna Baxter, George Follows, Daniel J Hodson, Ultan Mcdermott, Gary J Doherty, Inigo Martincorena, Laura Humphreys, Krishnaa Mahbubani, Kourosh Saeb Parsy, Koichi Takahashi, Margaret A Goodell, David Kent, Elisa Laurenti, Peter J Campbell, Raheleh Rahbari, Jyoti Nangalia, Michael R Stratton
Author Correction: The Long-Term Effects Of Chemotherapy On Normal Blood Cells, Emily Mitchell, My H Pham, Anna Clay, Rashesh Sanghvi, Nicholas Williams, Joanne I Hsu, Hyunchul Jung, Aditi Vedi, Sarah Moody, Jingwei Wang, Daniel Leonganmornlert, Michael Spencer Chapman, Ellie Dunstone, Anna Santarsieri, Alex Cagan, Heather E Machado, E Joanna Baxter, George Follows, Daniel J Hodson, Ultan Mcdermott, Gary J Doherty, Inigo Martincorena, Laura Humphreys, Krishnaa Mahbubani, Kourosh Saeb Parsy, Koichi Takahashi, Margaret A Goodell, David Kent, Elisa Laurenti, Peter J Campbell, Raheleh Rahbari, Jyoti Nangalia, Michael R Stratton
Faculty, Staff and Student Publications
No abstract provided.
Bard: A Seamless Two-Stage Dose Optimization Design Integrating Backfill And Adaptive Randomization, Yixuan Zhao, Rachael Liu, Jianchang Lin, Ying Yuan
Bard: A Seamless Two-Stage Dose Optimization Design Integrating Backfill And Adaptive Randomization, Yixuan Zhao, Rachael Liu, Jianchang Lin, Ying Yuan
Faculty, Staff and Student Publications
One common approach for dose optimization is a two-stage design, which initially conducts dose escalation to identify the maximum tolerated dose, followed by a randomization stage where patients are assigned to two or more doses to further assess and compare their risk-benefit profiles to identify the optimal dose. A limitation of this approach is its requirement for a relatively large sample size. To address this challenge, we propose a seamless two-stage design, BARD (Backfill and Adaptive Randomization for Dose Optimization), which incorporates two key features to reduce sample size and shorten trial duration. The first feature is the integration of …
Large-Scale Genome-Wide Analyses Of Stuttering, Hannah G Polikowsky, Alyssa C Scartozzi, Douglas M Shaw, Dillon G Pruett, Hung-Hsin Chen, Alexander S Petty, Shu-Hsien Cho, Yao Yu, Sahar Mozaffari, Christy L Avery, Kathleen Mullan Harris, Reyna L Gordon, Janet M Beilby, Kathryn Z Viljoen, Robin M Jones, Chad D Huff, Heather M Highland, Shelly Jo Kraft, Jennifer E Below
Large-Scale Genome-Wide Analyses Of Stuttering, Hannah G Polikowsky, Alyssa C Scartozzi, Douglas M Shaw, Dillon G Pruett, Hung-Hsin Chen, Alexander S Petty, Shu-Hsien Cho, Yao Yu, Sahar Mozaffari, Christy L Avery, Kathleen Mullan Harris, Reyna L Gordon, Janet M Beilby, Kathryn Z Viljoen, Robin M Jones, Chad D Huff, Heather M Highland, Shelly Jo Kraft, Jennifer E Below
Faculty, Staff and Student Publications
Developmental stuttering is a highly heritable, common speech condition characterized by prolongations, blocks and repetitions of speech. Although stuttering is highly heritable and enriched within families, the genetic architecture is largely understudied. We reasoned that there are both shared and distinct genetic variants impacting stuttering risk within sex and ancestry groups. To test this idea, we performed eight primary genome-wide association analyses of self-reported stuttering that were stratified by sex and ancestry, as well as secondary meta-analyses of more than one million individuals (99,776 cases and 1,023,243 controls), identifying 57 unique loci. We validated the genetic risk of self-reported stuttering …
Film Measurements Of Kilovoltage X-Ray Percentage Depth Doses For Different Energies And Field Sizes, Tze Yee Lim, Dershan Luo, Jamshid Moradi-Kurdestany, Xin Wang, Ramesh Tailor
Film Measurements Of Kilovoltage X-Ray Percentage Depth Doses For Different Energies And Field Sizes, Tze Yee Lim, Dershan Luo, Jamshid Moradi-Kurdestany, Xin Wang, Ramesh Tailor
Faculty, Staff and Student Publications
Objectives: Kilovoltage x-ray therapy, which includes superficial x-rays and orthovoltage x-rays, is particularly suited for treatments near the skin surface. Radiation dose deposition at depth is typically characterized by percentage depth dose (PDD) curves. However, PDD data are difficult to obtain in kilovoltage x-ray therapy, hence clinics often rely on British Journal of Radiology Supplement 25 (BJR-25) archival data. This study measured PDD for different energies and field sizes on the Xstrahl 300 kilovoltage x-ray therapy unit for comparison with BJR-25 data.
Methods: We irradiated EBT3 film in water using different energy and field size combinations, then, compared the acquired …
Computed Tomography Radiomics-Based Cross-Sectional Detection Of Mandibular Osteoradionecrosis In Head And Neck Cancer Survivors, Serageldin Kamel, Laia Humbert-Vidan, Zaphanlene Kaffey, Sarah Mirbahaeddin, Abdulrahman Abusaif, Kareem Wahid, Mohamed A Naser, Renjie He, Ahmed W Moawad, Khaled M Elsayes, Melissa M Chen, Adegbenga O Otun, Jillian Rigert, Mark S Chambers, Andrew Hope, Erin Watson, Kristy K Brock, Katherine Hutcheson, Lisanne Van Dijk, Amy C Moreno, Stephen Y Lai, Clifton D Fuller, Abdallah S R Mohamed, Md Anderson Head And Neck Cancer Symptom Working Group
Computed Tomography Radiomics-Based Cross-Sectional Detection Of Mandibular Osteoradionecrosis In Head And Neck Cancer Survivors, Serageldin Kamel, Laia Humbert-Vidan, Zaphanlene Kaffey, Sarah Mirbahaeddin, Abdulrahman Abusaif, Kareem Wahid, Mohamed A Naser, Renjie He, Ahmed W Moawad, Khaled M Elsayes, Melissa M Chen, Adegbenga O Otun, Jillian Rigert, Mark S Chambers, Andrew Hope, Erin Watson, Kristy K Brock, Katherine Hutcheson, Lisanne Van Dijk, Amy C Moreno, Stephen Y Lai, Clifton D Fuller, Abdallah S R Mohamed, Md Anderson Head And Neck Cancer Symptom Working Group
Faculty, Staff and Student Publications
Purpose: This study aims to identify radiomic features from contrast-enhanced CT (CECT) scans that differentiate osteoradionecrosis (ORN) from normal mandibular bone in head and neck cancer (HNC) patients treated with radiotherapy (RT).
Materials and methods: CECT images from 150 patients with confirmed ORN diagnosis (2008-2018) at MD Anderson Cancer Center (MDACC) were analyzed (80 % train, 20 % test). Radiomic features were extracted using PyRadiomics from manually segmented ORN regions and automated contralateral healthy mandible regions. Correlation analysis (r > 0.95) reduced features for model training. A random Forest (RF) classifier with Recursive Feature Elimination identified discriminative features. Explainability was assessed …
Addressing Challenges In Developing Treatments For Inherited Retinal Diseases: Recommendations From The Third Monaciano Symposium, Debra A Thompson, K Thiran Jayasundera, Oleg Alekseev, Robin R Ali, Alessia Amato, Isabelle S Audo, James W B Bainbridge, Eyal Banin, Cagri G Besirli, David G Birch, Kari E Branham, Artur V Cideciyan, Stephen P Daiger, Jacque L Duncan, Abigail T Fahim, John G Flannery, Roberto Gattegna, John R Heckenlively, Elise Héon, Alessandro Iannaccone, Naheed W Khan, Samer Khateb, Henry J Klassen, Bart P Leroy, Dario Marangoni, Michel Michaelides, David C Musch, Mark E Pennesi, Simon M Petersen-Jones, Eric A Pierce, Rajesh C Rao, José-Alain Sahel, Paul A Sieving, Enrica Strettoi, Cameron R Strong, Thomas J Wubben, Paul Yang, David N Zacks
Addressing Challenges In Developing Treatments For Inherited Retinal Diseases: Recommendations From The Third Monaciano Symposium, Debra A Thompson, K Thiran Jayasundera, Oleg Alekseev, Robin R Ali, Alessia Amato, Isabelle S Audo, James W B Bainbridge, Eyal Banin, Cagri G Besirli, David G Birch, Kari E Branham, Artur V Cideciyan, Stephen P Daiger, Jacque L Duncan, Abigail T Fahim, John G Flannery, Roberto Gattegna, John R Heckenlively, Elise Héon, Alessandro Iannaccone, Naheed W Khan, Samer Khateb, Henry J Klassen, Bart P Leroy, Dario Marangoni, Michel Michaelides, David C Musch, Mark E Pennesi, Simon M Petersen-Jones, Eric A Pierce, Rajesh C Rao, José-Alain Sahel, Paul A Sieving, Enrica Strettoi, Cameron R Strong, Thomas J Wubben, Paul Yang, David N Zacks
Faculty, Staff and Student Publications
Over the past decade, efforts focused on developing genetic therapies for inherited retinal diseases have advanced steadily to clinical trials and the development of a treatment, fueling optimism for the potential of precision medicines to provide safe and effective therapies for these rare conditions. Although several ongoing programs remain poised for success, numerous challenges have negatively impacted the ability to obtain regulatory approvals. The present position paper briefly summarizes recent advances and challenges in developing therapeutics for inherited retinal diseases, and presents a set of recommendations for moving the field forward. The priorities identified are discussed in terms of progress …
White Matter Abnormalities And Cognition In Aging And Alzheimer Disease, Christopher Peter, Aditi Sathe, Niranjana Shashikumar, Kimberly R Pechman, Abigail W Workmeister, Yuankai Huo, Jesse Mez, Logan C Dumitrescu, Katherine A Gifford, Corey J Bolton, Leslie S Gaynor, Shannon L Risacher, Lori L Beason-Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Duygu Tosun-Turgut, Mohamad Habes, Di Wang, Arthur W Toga, Paul M Thompson, Panpan Zhang, Kurt G Schilling, Marilyn Albert, Walter Kukull, Sarah A Biber, Bennett A Landman, Barbara B Bendlin, Sterling C Johnson, Julie Schneider, Lisa L Barnes, David A Bennett, Angela L Jefferson, Susan M Resnick, Andrew J Saykin, Paul K Crane, Michael L Cuccaro, Timothy J Hohman, Derek B Archer, Dimitrios Zaras, Yisu Yang, Alaina Durant, Praitayini Kanakaraj, Michael E Kim, Chenyu Gao, Nancy R Newlin, Karthik Ramadass, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Seo-Eun Choi, Brandon Klinedinst, Michael L Lee, Phoebe Scollard, Emily H Trittschuh, Elizabeth A Sanders
White Matter Abnormalities And Cognition In Aging And Alzheimer Disease, Christopher Peter, Aditi Sathe, Niranjana Shashikumar, Kimberly R Pechman, Abigail W Workmeister, Yuankai Huo, Jesse Mez, Logan C Dumitrescu, Katherine A Gifford, Corey J Bolton, Leslie S Gaynor, Shannon L Risacher, Lori L Beason-Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Duygu Tosun-Turgut, Mohamad Habes, Di Wang, Arthur W Toga, Paul M Thompson, Panpan Zhang, Kurt G Schilling, Marilyn Albert, Walter Kukull, Sarah A Biber, Bennett A Landman, Barbara B Bendlin, Sterling C Johnson, Julie Schneider, Lisa L Barnes, David A Bennett, Angela L Jefferson, Susan M Resnick, Andrew J Saykin, Paul K Crane, Michael L Cuccaro, Timothy J Hohman, Derek B Archer, Dimitrios Zaras, Yisu Yang, Alaina Durant, Praitayini Kanakaraj, Michael E Kim, Chenyu Gao, Nancy R Newlin, Karthik Ramadass, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Seo-Eun Choi, Brandon Klinedinst, Michael L Lee, Phoebe Scollard, Emily H Trittschuh, Elizabeth A Sanders
Faculty, Staff and Student Publications
Importance: There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD).
Objective: To investigate the associations between tract-specific white matter microstructure and cognitive performance and decline in aging and AD-related cognitive impairment.
Design setting and participants: This prognostic study of aging and AD, a secondary data analysis of multisite cohort studies, acquired data from 9 cohorts between September 2002 and November 2022. Participants were eligible if they had diffusion-weighted magnetic resonance imaging (dMRI) data, domain-specific cognitive composite z scores, demographic and clinical data, were …
Identification Of Crustose Coralline Algae Species In Florida And Their Ability To Induce Larval Settlement Of Caribbean Corals, Danielle Macias
Identification Of Crustose Coralline Algae Species In Florida And Their Ability To Induce Larval Settlement Of Caribbean Corals, Danielle Macias
All HCAS Student Capstones, Theses, and Dissertations
Crustose coralline algae (CCA) are a diverse, globally spread and yet poorly studied group of benthic organisms. They act as settlement cues for coral larvae, but this interaction is often species-specific, as CCA species can be either inducers or inhibitors to larval settlement and metamorphosis. Despite this importance, information on Caribbean CCA distribution, diversity, and impact on coral species is limited due to the difficulty in identifying them. In the present study, CCA samples were collected from seven different reef sites in the southeastern region of Florida’s Coral Reef and genetically identified using molecular analyses. Some of the samples collected …
Environmental Impacts Of Land Use Change In Industrial Areas, Dwi Nowo Martono, Aruminingsih Aruminingsih
Environmental Impacts Of Land Use Change In Industrial Areas, Dwi Nowo Martono, Aruminingsih Aruminingsih
Journal of Environmental Science and Sustainable Development
Industrial development in Indonesia has been predominantly concentrated on Java Island, particularly in Karawang Regency, West Java Province. Covering an area of 175,327 hectares, Karawang has been identified as a strategic region for national food security. The Minister of Agrarian Affairs and Spatial Planning designated 95,667.45 hectares of rice fields as protected agricultural land. However, the expansion of industrial and residential areas within the regency poses a significant threat to its role as the national rice granary and to broader food security. As industrial land occupancy increases, the environmental capacity to support rice production and ensure national food security declines. …
Sustainable Water Management In Universities: Perceptions, Behaviours, And Challenges, Hastin Setiani, Dwita Sutjiningsih, Riri Fitri Sari
Sustainable Water Management In Universities: Perceptions, Behaviours, And Challenges, Hastin Setiani, Dwita Sutjiningsih, Riri Fitri Sari
Journal of Environmental Science and Sustainable Development
Universities are increasingly adopting the “living laboratory” model to implement and evaluate sustainability innovations. These settings enable students, staff, and stakeholders to co-create and test real-world solutions, including those related to water use. Universitas Indonesia promotes sustainability through an integrated approach encompassing policy development, academics programs, and infrastructures. Prior studies using the Theory of Planned Behavior (TPB) have demonstrated that attitudes and perceived norms significantly influence sustainable behavior. However, limited research has examined how these dynamics operate within Indonesian universities or how university-based initiatives may contribute to broader urban water management. This study addresses that gap by examining perceptions, behaviors, …
Convergence In Action: Where Environmental Science Meets Sustainable Development Practice, Herdis Herdiansyah
Convergence In Action: Where Environmental Science Meets Sustainable Development Practice, Herdis Herdiansyah
Journal of Environmental Science and Sustainable Development
Since the introduction of the Sustainable Development Goals (SDGs), the pursuit of human well-being through development and planetary sustainability for a better future has become a global discourse (de Jong & Vijge, 2021; Naseer et al., 2025; Arora-Jonsson, 2023). The SDGs have catalyzed interdisciplinary dialogue and strengthened global commitment (Naseer et al., 2025) by emphasizing the balance and integration of economic, social, and environmental aspects (Sedovs et al., 2025). However, the assumption that all goals can be achieved simultaneously and harmoniously seems hasty and potentially ignores the inherent tensions between ecological and …