Digital Commons Network^™

Prepregnancy Overweight And Obesity In Kuwait Birth Cohort Study, Abdullah Al-Taiar, Ali H. Ziyab, Eelaf A. Husain, Maryam M.Y. Mohammad, Maryem A. Shamsah, Noor Salah Alali, Reem Sharaf-Alddin, Majeda S. Hammoud

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Objectives: This study aimed to estimate the prevalence of prepregnancy obesity and overweight, and to identify a set of sociodemographic factors that could guide weight management interventions for women prior to conception.

Design, Sample, and Measurements: Pregnant women (N = 989) were recruited in the Kuwait Birth Cohort Study during the period June 2017 to February 2020. Prepregnancy weight and height were self-reported, while current weight and height were measured in a standardized procedure. Data on sociodemographic factors were collected through face-to-face interviews conducted by a trained data collector. Multinomial logistic regression was used to investigate the association between sociodemographic …

Independent And Interactive Effects Of Stack Height And Heel Width On Spatiotemporal Parameters, Knee Joint Kinetics, And Ground Reaction Forces During Running, Hao Cai

College of Graduate Studies: Theses & Dissertations

This study investigated the independent and interactive effects of stack height (SH) and heel width (HW) on lower-extremity biomechanics during running. Specifically, the study examined how variations in midsole geometry influenced spatiotemporal parameters, knee joint kinetics, and ground reaction forces (GRF). Twelve recreational runners (8 males, 4 females) completed treadmill running trials at 16 km/h under nine shoe conditions that systematically varied in SH (25, 45, and 65 mm) and HW (81, 93, and 105 mm). Lower-extremity kinematics were collected using a Theia3D markerless motion capture system, and GRF data were recorded using an instrumented treadmill. A two-way repeated-measures ANOVA …

Influence Of Footwear Geometry On Lower Limb Stiffness During Running, Hongjiao Duan

College of Graduate Studies: Theses & Dissertations

This study examined how footwear geometry, specifically stack height and heel width, influences lower-limb stiffness during treadmill running. Twelve recreationally active runners completed treadmill running trials at 4.44 m/s in nine prototype shoe conditions that differed in stack height (25, 45, and 65 mm) and heel width (81, 93, and 105 mm). Vertical stiffness, leg stiffness, and sagittal-plane hip, knee, and ankle joint stiffness were calculated from synchronized markerless motion capture and force data. A two-way repeated-measures ANOVA (stack height X heel width) was used to test footwear effects. Leg stiffness was not significantly affected by stack height or heel …

Impact Of Tactical Breathing On Marksmanship And Cognitive Function After Anaerobic Fatigue In Law Enforcement Personnel, Jackson D. Gilleland

College of Graduate Studies: Theses & Dissertations

Background: Tactical breathing is commonly used in law enforcement training to regulate stress, yet limited evidence exists regarding its acute effectiveness following physical fatigue. Purpose: To examine whether a brief tactical breathing intervention improves shooting performance and heart rate variability (HRV) following anaerobic fatigue in law enforcement officers. Methods: Thirty-eight officers completed baseline HR/HRV and a shoot/no-shoot scenario, followed by a maximal 500-m row and post-fatigue shooting. Participants were assigned to either a control group or a tactical breathing group, which received brief instruction and coaching before post-testing. Results: No significant between-group differences were observed for A-zone accuracy, shot time, …

Assessing Climate-Driven Shifts In Floral Resource Availability For Bees On Barrier Islands In The Southeastern U.S., Hannah Brown

College of Graduate Studies: Theses & Dissertations

Climate change can alter the timing of bee and angiosperm phenology, potentially reshaping the seasonal availability of floral resources for bee species. Although plant-pollinator phenology has been widely studied in temperate systems, less is known about these dynamics in subtropical coastal ecosystems, such as barrier islands in the southeastern United States. In this study, we examined climate-driven changes in bee activity and floral resource availability across 16 barrier-island sites spanning from Florida to Virginia. Using museum bee occurrence records, herbarium-derived flowering phenology models, site-specific floristic inventories, and published bee-plant interaction data, we estimated species-specific bee activity periods and daily floral …

Cogram: A Computational Pipeline For Genome Assembly And Reconstruction Using Graph Neural Networks, William Coggins

College of Graduate Studies: Theses & Dissertations

Genome assembly — the reconstruction of a complete DNA sequence from short, overlapping reads — remains a fundamental challenge in computational biology. A central difficulty is distinguishing true genomic overlaps from spurious connections arising from repetitive sequences, a task that traditional assemblers address through hand-tuned heuristic rules applied to de Bruijn or overlap graphs. This thesis introduces COGRAM (Coggins–Ramasamy Assembly Method), a genome assembly pipeline that reframes sequence reconstruction as an edge classification task on a k-mer overlap graph, replacing heuristic graph cleaning with a learned model.

COGRAM constructs a directed overlap graph from raw sequencing reads using a k-mer …

Sexual Dimorphism In The Immune Defense Mechanisms Against A Systemic Bacterial Infection In The Cat Flea (Ctenocephalides Felis), Ashley Lynch

College of Graduate Studies: Theses & Dissertations

Fleas defend against infection through the activation of both humoral and cellular innate immune responses. Previous research in female cat fleas demonstrated increased immune activity following a systemic bacterial infection. However, comparable data for males and sex-based comparisons are limited. In this study, we investigated differences in innate cellular immune responses between male and female cat fleas following systemic infection with Gram-negative Escherichia coli. Bacterial load was quantified using colony-forming units 24 h post-infection. Immune function was assessed via phagocytic index and capacity. Survival and total circulating hemocyte counts were evaluated across infected, sterile-injected, and untreated groups. Male fleas …

Evaluating Source Material And Seed Propagation Techniques For Spartina Alterniflora To Enhance Salt Marsh Restoration In Coastal Georgia, Maygan Palacios

College of Graduate Studies: Theses & Dissertations

Salt marshes provide critical ecosystem services, including carbon sequestration, flood attenuation, and habitat for diverse aquatic and terrestrial species. Despite their ecological importance, these habitats are increasingly threatened by anthropogenic activities and rising sea levels. To protect and restore salt marshes and their ecosystem services, restoration efforts using living shorelines (LS) have become more common. Along the Eastern and Gulf coasts of the United States, the native grass Spartina alterniflora is commonly used in LS installations for its key role in salt marsh food webs, resilience to abiotic stress, and ability to stabilize and build sediment. Previous studies have documented …

Cytonuclear Incompatibilities In Hybrid Systems: Oxidative Phosphorylation Capacity And Nuclear Marker Transmission Ratio Distortion In Hybrids Of An Introgressed Strain Of Parasitoid Wasp, Julie Kessler

College of Graduate Studies: Theses & Dissertations

Speciation is an evolutionary process resulting in the divergence of populations into reproductively isolated species, a key concept that supplies our planet with an abundance of biodiversity. Mechanisms for speciation center on obstacles to fertilization and include post-zygotic barriers, such as intrinsic deleterious interactions, that arise in hybrid systems where genetic variants are combined. Genes from separate parent lineages are often incompatible due to the co-evolution of paired genes within a singular species not matching their complement genes in another species, and the result is a reduction in fitness of the hybrid when these genes come together. The mitochondrial OXPHOS …

Female Athletes’ Mental Health Help-Seeking Experiences: Understanding The Impact Of The Coach-Athlete Relationship And Coach Sex, Verena Zaisberger

College of Graduate Studies: Theses & Dissertations

Mental health help-seeking remains stigmatized in the world of sports (Cosh et al., 2024). Evidence suggests that female athletes may prefer to disclose vulnerable topics to individuals of the same sex (Keil et al., 2023), including help-seeking (O’Keeffe et al., 2022). However, no investigations have explored how coach sex or the coach-athlete relationship may influence female athletes help-seeking experiences. This is despite the importance of coaches in promoting and facilitating mental health services utilization (Bissett et al., 2020). To further understand this topic, the aim of this study was to explore what female athletes’ mental health help-seeking experiences are under …

The Effect Of The Affordable Care Act Medicaid Expansion On The Risk Of Hospital Closure And Adolescent Hpv Immunization In Rural Counties, Juliette Des Rosiers

Scripps Senior Theses

From 2005 to 2025, over 200 rural hospitals shut their doors, often citing increased operational costs, staffing shortages, low patient volume, regulatory barriers, financial challenges exacerbated by the COVID-19 pandemic, and uncompensated care as common contributors to the closures. Rural patients are often referred by their primary care physician to a hospital for regular immunizations, since smaller clinics have less capacity to provide immunizations due to a shortage of pediatricians and limited vaccine stock. A crucial vaccine that is not required by schools and underutilized in rural areas is that against human papillomavirus (HPV), a virus that infects cutaneous and …

Examining The Factor Structure And Subgroup Invariance Of The Deliberate Denial Of Disordered Eating Behaviors Scale, Lindsay Howard, Sage Hawn, Kayla D. Pitchford, Riley Mcgrath, Aubri Farniok, Arturo Sesma, Kristin E. Heron

Psychology Faculty Publications

The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the Denial of Disordered Eating Behaviors Scale (DDEBS-12) and tested measurement invariance across gender identity, racial identity, and levels of disordered eating in a non-clinical undergraduate sample (N = 3285). Confirmatory factor analyses did not support the original unidimensional structure. Instead, a seven-item model assessing denial of dietary restriction demonstrated the best fit and was renamed the DDEBS-restriction. The revised scale showed good internal consistency …

Micrornas Regulated By Pregnancy Target Antiviral And Cancer Immunity Overlapping With The Hiv Interactome, Paula F. T. Cezar-De-Mello, Jonathan M. Dreyfuss, Pai-Lien Chen, Hidemi Yamamoto, Xiaoming Gao, Hui Pan, Charles Morrison, Gustavo F. Doncel, Robert L. Barbieri, Raina N. Fichorova

CONRAD Publications

Innate immunity predictors of HIV-1 risk and pathogenesis vary with reproductive hormones, pregnancy, and lactation, yet the underlying mechanisms remain unclear. We hypothesized that pregnancy-associated physiological adaptations alter systemic microRNA (miRNA) expression, thereby regulating immunity, pathogenesis and susceptibility to infection. We analyzed 174 serum samples from 88 participants in a longitudinal cohort from Uganda and Zimbabwe across pre-pregnancy (PP), pregnancy (P), and postpartum breastfeeding (BF). Cell-free peripheral blood miRNAs (n = 2083) were profiled using HTG EdgeSeq. Pregnancy-specific miRNAs were identified by intersecting differentially expressed (DE) miRNAs from P vs. PP and P vs. BF comparisons. miRNA targets and pathways …

Ex Vivo Sensitivity Assays With Molecular Validation To Guide Preclinical Drug Selection For Schwann Cell Tumors, Ethan W. Hass

Graduate Studies Theses and Dissertations 2026

Schwann cells are the glial cell of the peripheral nervous system. They are dependent on receptor tyrosine kinase-mediated RAS signaling, cell matrix adhesion, and cell-cell contact to proliferate during nerve development and repair. These pathways become deregulated with loss of function of the merlin tumor suppressor encoded by NF2, leading to benign tumors called schwannomas. Patients with NF2-related schwannomatosis (NF2-SWN) develop bilateral vestibular schwannomas that cause hearing loss, tinnitus, and death from brainstem compression if untreated. Severe NF2-SWN causes multiple spinal and peripheral schwannomas and neuropathic pain. Schwannomas require careful monitoring, trial and error use of repurposed anti-cancer …

The Influence Of Limb Dominance On Neural Activation Patterns While Performing Different Motor Control Tasks, Kevin A. Hooks

Graduate Studies Theses and Dissertations 2026

Humans interact with our environment in many ways. One of the most outward-facing aspects of this is limb dominance. The neural underpinnings of limb dominance remain in question today. The objective of this research was to use different methods to analyze neural activation while subjects performed upper extremity motor tasks while recording electroencephalography (EEG). The first experiment used decoding methods to examine whether neural signals collected from the contralateral limb could be used to train a classifier to test on the ipsilateral limb during a reach-to-grasp or reach-to-touch task. It was determined above chance level that within-subject action and direction …

Homoplasy Of Maxillary Orthognathism In Derived Homo, Jared Jordan

Graduate Studies Theses and Dissertations 2026

The evolution of the orthognathic condition in the genus Homo represents a monumental transition toward the facial morphology of modern humans from that of earlier hominins, but the phylogenetic positioning of this transformation remains poorly understood. This study investigated temporal trends in maxillary and mandibular prognathism in the genus Homo, and whether maxillary and mandibular shortening in East Asian H. erectus and later East Asian Middle Pleistocene Homo (e.g., Homo longi) represent independent derivations of orthognathic morphology, thereby making orthognathism a homoplasy in the genus Homo. Using a sample of roughly 109 cranial and mandibular specimens spanning …

Coordinated Whole-Body Dynamic Pressing And Reaction Inhibition — Impact Of High-Intensity Intermittent Exercise And Dehydration, Modesto A. Lebron

Graduate Studies Theses and Dissertations 2026

Dynamic whole-body pressing movements are an imperative aspect of various sport and occupational settings, requiring motor coordination to kinetically sequence from lower- to upper-extremities. Recently, exercises such as the jammer arm punch press (JPP) have increased in popularity, promoted as an exercise to improve strength and force transfer. While the JPP has observed increased practical utility, its use in research is limited potentially due to difficulties with quantifying exercise intensity. One method to quantify exercise intensity is the assessment of velocity, serving as the basis for velocity-based training. For optimization, this strategy requires an understanding of velocity ranges and their …

Michigan Academician Volume 50, Issue 2

Michigan Academician

Volume 50, Issue 2 - Abstract Issue

Biomarkers Of Foraging And Reproduction In Captive Adult Female Hawksbill Sea Turtles (Eretmochelys Imbricata), Joslyn Blessing Kent, Kari Renee Dawson, Shingo Fukada, Masae Makabe, Isao Kawazu, Ken Maeda, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Hawksbill sea turtles (Eretmochelys imbricata) are listed as critically endangered by the International Union for the Conservation of Nature (IUCN). To implement best conservation practices for this species, its biology should be well understood. Attempting to characterize the foraging physiology of free-ranging hawksbill sea turtles is complicated by the fact that sampling is typically limited to nesting females during the reproductive season. Without data from non-reproductive periods, it is difficult to determine whether observed physiological values reflect baseline conditions or are specific to the energetically demanding nesting season. Accordingly, in this study, we described the physiology of foraging in …

Vitamin D Status During Pregnancy Modulates The Effect Of Pre-Pregnancy Obesity On Gestational Diabetes Mellitus Risk: A Birth Cohort Study, Ali H. Ziyab, Abdullah Al-Taiar, Reem Al-Sabah, Majeda S. Hammoud, Saeed Akhtar

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Objective:

To determine whether gestational vitamin D status modulates the effect of pre-pregnancy obesity on gestational diabetes mellitus (GDM) risk while stratifying by maternal age.

Design:

Birth cohort.

Setting:

A major maternity hospital in Kuwait.

Participants:

Pregnant women in their second/third trimester of gestation were enrolled. Pre-pregnancy body mass index (BMI, kg/m²) was categorized as under/normal weight (< 25.0), overweight (25.0 to < 30.0), and obesity (≥30.0). Gestational 25-hydroxyvitamin D concentrations were categorized as deficiency (< 50 nmol/L) or insufficiency/sufficiency (≥50 nmol/L). GDM status was ascertained according to international guidelines. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) were estimated using logistic regression.

Results:

Data from 957 pregnant women were analyzed, with GDM affecting 166 (17.4%) pregnancies. Pre-pregnancy obesity and gestational vitamin D deficiency was ascertained in 275 (28.7%) and 533 (55.7%) pregnant women, respectively. The association between pre-pregnancy obesity and GDM risk differed according …

Urban Trees In The Urban Hydrology Cycle, Jorge R. Vera

Theses, Dissertations and Capstones

In urban forestry, trees provide numerous economic, ecological, and aesthetic benefits to the surrounding community. One of their key roles is intercepting stormwater runoff, reducing flooding risk, and improving water quality. Chapter 1 of this thesis characterized the ecological and economic contributions of urban trees on the Marshall University campus and provides guidance on their management and conservation in the future. Chapter 2 examined how urban tree species modify the urban hydrology cycle by altering the volume and timing of precipitation delivery. In Chapter 1, we inventoried 114 acres of Marshall University's main campus in Huntington, WV, from June 28 …

Adnexal Magnetic Resonance (Adnex –Mr) Scoring System; A New Standardized Method For Characterization Of Adnexal Masses Inside Mansoura University Hospitals, Nora Diaa Ali Okab, Basma Elged, Sherif Abdel Fatah Moustafa, Sieza Samir, Yasser.M. Mesbah

Mansoura Medical Journal

Background Gynecologic masses are the most common subject of gynecologic imaging. The usefulness of MRI is high in the characterization of adnexal masses. The ADNEX MR classification framework was launched to stratify sonographically identified adnexal masses in to five groups based on their probability of malignancy: grade 1 (no lesion), grade 2 (benign), grade 3 (probably benign), grade 4 (indeterminate), and grade 5 (probably malignant). Aim to determine the accuracy of the ADNEX MR scoring system in classification of adnexal masses at Mansoura University Hospitals (MUH). Methods A total of 48 female patients with 52 adnexal masses on ultrasound were …

Use Of Thyroid Imaging Reporting And Data Systems (Tirads) Ultrasound In Differential Diagnosis Of Thyroid Nodules, Aya Mohamed Hamed Abdelaal, Ghada M Ahmed Gaballah, Donia Mohamed Sobh

Mansoura Medical Journal

Background: Thyroid nodules refer to masses of abnormally proliferating cells with abnormal tissue stiffness in thyroid. This study aimed to assess diagnostic accuracy of Thyroid Imaging Reporting and Data System in differentiating benign from malignant thyroid nodules.

Methods: This cross-sectional study included forty adult patients with sixty-two thyroid nodules. A 7.5-10 MHz linear array transducer was used to perform imaging protocol. Three-dimensional measurements were done on nodules. All thyroid nodules were  examined using doppler ultrasound. All thyroid nodules were described in terms of composition, echogenicity, margins, shape and echogenic foci.  According to ACR TI-RADS,  the points were given …

Clinical And Dermoscopic Nail Changes In Patients With Chronic Kidney Disease: A Cross-Sectional Study, Ghada Nagy Mansour Borham, Hassan Abdel-Raheim Fayed, Eman Nagy Ahmed Abdelrazik, Amany Awad Mohamed

Mansoura Medical Journal

Background: Nail abnormalities are commonly observed among patients with chronic kidney disease (CKD) and may reflect underlying systemic and metabolic alterations. Dermoscopy (Onychoscopy) has emerged as a valuable noninvasive tool for detecting subtle nail changes.

Aim:  To describe the patterns and dermoscopic features of nail changes in patients with chronic kidney disease (CKD) and to explore their association with disease severity and renal function parameters.

Methods: This cross-sectional descriptive study included 127 patients with different stages of CKD. All participants underwent a comprehensive clinical and dermoscopic evaluation of the nail apparatus. Dermoscopic findings included longitudinal ridging, white …

A Comparative Study Of Topical 5% 5-Fluorouracil With Needling Versus 100% Trichloroacetic Acid With Needling Versus Needling Alone In Treatment Of Multiple Warts, Nesma Abd-Elmonem Saad, Hassan A. Fayed, Manar Ali

Mansoura Medical Journal

Aim: This study aimed to compare the efficacy and safety of topical 5% 5-Fluorouracil (5-FU) with Needling versus 100% Trichloroacetic acid (TCA) with Needling versus Needling Alone in treatment of multiple warts.

Methods: This study included a total of 60 patients clinically diagnosed with multiple warts, who were randomly allocated (computer-generated simple randomisation, 1:1:1, concealed in sequentially numbered opaque sealed envelopes) into three equal groups (n=20 per group). The first group received 100% TCA with Needling; the second group received topical 5% 5-FU combined with Needling; the third group underwent Needling alone. The study was single-blinded at the level …

Active Deresuscitation Strategies After Septic Shock: A Scoping Review, Alrefaey K. Alrefaey, Rania E Elbadrawy, Mohamed Aboelela, Mohammed Mamoun

Mansoura Medical Journal

Background: Fluid overload in septic shock patients is linked to higher morbidity and mortality. After the stabilization phase, fluid restriction may not result in the resolution of tissue edema. Active deresuscitation refers to the use of diuretics or ultrafiltration for the removal of excess fluids. Objectives: This review explores the current practices applied for the active deresuscitation strategies after stabilization of septic shock patients.  Search strategy: A literature search was performed through the following databases: Medline, PubMed, Google Scholar, Web of Science, and Scopus for relevant studies from 2015 to January 2026. Selection criteria:  The selected articles included …

Validation Of Anorectal Manometry Based On The Continence Clinical Scoring Systems For Evaluation Of Fecal Continence In Patients With Anorectal Malformations, Momen Abdelglil, Mohamed El-Sherbiny, Mahmoud Abdelwahab, Adham Elsaeid

Mansoura Medical Journal

Background/purpose: Anorectal malformations (ARM) are complex anomalies associated with long-term problems such as fecal incontinence. Clinical scoring systems are commonly used to assess bowel function but lack proper validation. Anorectal manometry is an objective tool for evaluating anorectal function. This study aimed to correlate anorectal manometric parameters and clinical continence scoring systems to enhance the postoperative evaluation of children with ARMs.

Patients and methods:

We conducted a descriptive cross-sectional study including 47 children who had undergone definitive surgical repair for ARMs between January 2010 and June 2021. Fecal continence was assessed using the Kelly and Templeton & Ditesheim scoring systems. …

Perinatal Inflammation And Oxidative Stress Alter Adult Rat (Rattus Norvegicus) Motor Behavior, Alexander Young

Honors College Theses

Recent evidence in comparative animal models suggests that early life exposure to elevated inflammation (via LPS exposure) and oxidative stress (via acetaminophen exposure) may synergistically interact to alter typical neurodevelopmental trajectories, resulting in lasting effects on both behavior and gut-brain neurochemistry. The current study observed emotional and motor behaviors and collected fecal-boli to measure Tyrosine (TE) levels in male and female Long-Evans (Rattus norvegicus) rats. Subjects were either treated with [1] saline [2] lipopolysaccharide (LPS) to introduce an inflammatory state, [3] acetaminophen (APAP) to introduce oxidative stress, or [4] a dual-hit of both LPS + APAP on postnatal day (PD) …

Cross-Domain Antimicrobial Resistance In Poultry Farming: A One Health Assessment Of Antimicrobial Use And Multidrug Resistance In Kiambu County, Kenya, Ann Kangai Munene, Peter Muiruri Mwangi, Lilly Caroline Bebora, Christine Minoo Mbindyo, John Muthini Maingi

All Peer-Reviewed Publications

Background and Aim: Antimicrobial resistance (AMR) has emerged as a major One Health threat driven by inappropriate antimicrobial use (AMU) in humans, animals, and the environment. Poultry production is recognized as a key reservoir of antimicrobial-resistant bacteria, yet few studies in Kenya examine AMU and AMR across interconnected human–animal–environment domains. This study assessed AMU patterns among poultry farmers in Kiambu County and characterized phenotypic resistance in Escherichia coli and Enterococcus spp. isolated from humans, chickens, and chicken environments. Materials and Methods: A cross-sectional study was conducted from May to September 2024, involving 102 poultry farms. Farm demographics and AMU data …

Oligonychus Trichardti (Acari: Tetranychidae) Associated With Urochloa Grasses In Kenya: An Integrative Taxonomic Approach, Paula Espitia-Buitrago, Claudia Perea, Lavender A. Odhiambo, Rosa N. Jauregui, Frank Chidawanyika

All Peer-Reviewed Publications

Spider mites represent a significant constraint to improved forage grass adoption in East Africa, particularly affecting Urochloa cultivars that are crucial for addressing the region’s 40% livestock feed gap. This study employed an integrative taxonomic approach combining morphological and molecular analyses to identify a spider mite species infesting Urochloa interspecific grasses in Kenya. A colony of 80 spider mites was established from symptomatic Urochloa hybrid cv. Cayman plants collected from Mbita Point, Kenya, showing characteristic foliar chlorosis and necrotic spots. Morphological examination of 46 slide-mounted specimens using Hoyer’s medium revealed consistent morphotypical features characteristic of Oligonychus (Reckiella) trichardti Meyer, 1974. …