Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2701 - 2730 of 50190

Full-Text Articles in Entire DC Network

Heterologous Expression And Application Of A Thermophilic Lytic Polysaccharide Monooxygenase, Le Xie, Longyun Peng, Yun Hu, Hongyan Ren, Haiyan Sun, Fubao Sun May 2025

Heterologous Expression And Application Of A Thermophilic Lytic Polysaccharide Monooxygenase, Le Xie, Longyun Peng, Yun Hu, Hongyan Ren, Haiyan Sun, Fubao Sun

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the application of a novel thermophilic lytic polysaccharide monooxygenase (LPMO ) in the efficient cellulase-mediated hydrolysis of lignocellulosic substrates.[Method ] The thermophilic enzyme mgLPMO 10,derived from a compost metagenome,was heterologously expressed in Escherichia coli (E.coli ).Its expression level was improved by modifying the signal peptide of the expression vector and induction conditions (temperature,IPTG concentration,and induction time ).The enzyme was then characterized in terms of the optimal temperature,optimal pH,thermal stability,pH stability,and the effects of metal ions on its enzyme activity.Subsequently,the synergistic hydrolysis efficiency of mgLPMO 10 with two thermophilic endoglucanases (TnCelB and DtCelB ) …

Go to article

Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu May 2025

Phrg-Rapg-Degu Quorum Sensing Regulates Menaquinone- 7 Production In Bacillus Subtilis, Junbao Huang, Xilin Huang, Yu Chen, Xuli Gao, Yani Luo, Wei Tao, Yongyuan Liu, Mingyu Guo, Jing Wu, Yan Liu

Journal of Food Science and Biotechnology

[Objective ] The effects of the transcription regulation system on menaquinone- 7 (MK- 7) production in Bacillus subtilis (B.subtilis ) 168 were studied by excavating transcription regulators.[Method ] With the signal molecule PhrG pentapeptide,RapG,and the transcription regulator DegU,a PhrG-RapG-DegU regulatory system was successfully constructed in B.subtilis 168 to fine-tune the expression of key genes,so that the expression of key genes in the MK- 7 synthesis pathway can respond to the changes in cell density.[Result ] The production of MK- 7 in strain BS 06 reached 102.47 mg/L through this system.[Conclusion ] Fine tuning of quorum sensing can effectively improve the …

Go to article

Research Progress In Effects Of Bile Acids And Their Receptors On Intestinal Function, Lu Jin, Jiansheng Jin, Yongqiang Gu, Lulu Zhou, Feifei Han May 2025

Research Progress In Effects Of Bile Acids And Their Receptors On Intestinal Function, Lu Jin, Jiansheng Jin, Yongqiang Gu, Lulu Zhou, Feifei Han

Journal of Food Science and Biotechnology

Bile acids are the main end products of cholesterol metabolism in the body,playing an important regulatory role in the digestion and metabolism of nutrients,especially lipids.The intestine is the main organ for digestion and absorption,as well as an important site for bile acids to achieve liver-intestinal circulation.Its function is closely related to the interaction between bile acids as signaling molecules and their receptors.Focusing on the metabolism and regulatory mechanism of bile acids,the author reviews the roles and underlying mechanisms of bile acids and their receptors in regulating intestinal barriers,immune function,and gut microbiota.The aim is to provide reference for related research on …

Go to article

Using Cutting Immersion To Apply Rooting Hormone For Propagation Of Camellia Japonica., Tanner R. Marlow, Richard L. Harkess May 2025

Using Cutting Immersion To Apply Rooting Hormone For Propagation Of Camellia Japonica., Tanner R. Marlow, Richard L. Harkess

Honors Theses

Few varieties of Camellia japonica have a high success rate in rooting cuttings. Once rooted, the subsequent growth rate is slow and differs by variety. This makes the commercial production of Camellia challenging. Previous research on C. japonica propagation confirms that using a basal cut dip in indole-3-butyric acid (IBA) is effective in rooting C. japonica. However, basal dip applications can be time-consuming. Foliar applications and total cutting immersion are more efficient methods of rooting hormone application, but they have not been thoroughly tested with Camellia. The objective of this research was to determine the effective IBA concentration applied as …

Go to article

Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell May 2025

Turtle Creek Tree Restoration Project, Rebecca Beneroff, Risa Kanefsky, Max Dicerbo, Pj Newhart, Amanda Mitchell

Final Reports in ENST 411: Environmental Community Projects

Over the course of this project our group members Rebecca, Max, PJ, Amanda, and Risa worked closely with Jim Knight and Brian Auman from Turtle Creek Park to help research, plan, and execute a tree transplanting event that would be efficiently implemented and environmentally sound. This work involved extensive preparatory work in the park including soil testing, bare leaf tree identification, tree and shrub species characterization, and recommendation. The entire process was rooted in the most up to date literature and scientific practices surrounding bare root tree nurseries, existing land management plans, invasive species and public park management, ecological succession, …

Go to article

Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n May 2025

Complete Genome Analyses Of A Novel Narlivirus Identified In The Ectomycorrhizal Fungus Amanita Vidua, Ilgaz Akata, Eda Kumru, Gülce Edi̇ş, Ertuğrul Kaya, Ergi̇n Şahi̇n

Turkish Journal of Botany

The widespread utilisation of deep sequencing has dramatically enhanced and revolutionised our understanding of virus diversity, particularly in complex environments such as soil and biological samples. This research explored mycovirus sequence analyses in the ectomycorrhizal fungus Amanita vidua, utilising deep sequencing alongside total double-stranded RNA (dsRNA) extractions. Our investigation unveiled a unique member of the proposed family, Narliviridae, designated as Amanita vidua narlivirus 1 (AvNV1), in an A. vidua specimen. AvNV1, classified under Amabiliviricetes, possesses a distinct genome structure and sequence attributes. T horough analyses indicated that AvNV1 exhibits sequence similarities with other mycoviruses from the proposed family Narliviridae and …

Go to article

Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake May 2025

Unveiling The Physical Interaction Between Gsnor1 And Trx-H Isoforms, Anika Tabassum, Gary J. Loake

Turkish Journal of Botany

This study aims to investigate any possible interaction between two highly conserved regulators of cellular SNO levels: S-nitrosoglutathione reductase (GSNOR1) and thioredoxin (TRX). These two enzymes control global S-nitrosylation levels and thus impact the cellular redox state during immune responses. A mutant line (Δtrx1trx2sfa1) of Saccharomyces cerevisiae MaV203 strain was generated to explore this possibility rather than using a classical strain. We identified and characterized the physical interaction between GSNOR1 and Arabidopsis cytosolic h isoforms in a yeast two-hybrid screen. Out of the seven TRX isoforms, AtGSNOR1 displayed a high interaction with AtTRXh3, AtTRXh4, and AtTRXh5 (AtTRXh5>AtTRXh4 & AtTRXh3). …

Go to article

Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins May 2025

Peripheral Neuroimmune Mechanisms Of Chronic Back Pain, Aleyah Esther Goins

Biomedical Sciences ETDs

Chronic back pain (CBP) affects 1 in 10 people worldwide, reducing mobility, productivity, and quality of life. Despite its prevalence, non-addictive treatments remain limited due to an incomplete understanding of chronic pain mechanisms. This dissertation examines peripheral neuroimmune interactions in CBP using a urokinase-type plasminogen activator (uPA)-induced mouse model (uPA-CBP). uPA, a pro-inflammatory serine protease, was injected into the L2/L3 lumbar spinous ligament, inducing prolonged mechanical and cold hypersensitivity. Flow cytometry of dorsal root ganglia (DRG) showed increased CD45+CD11b+ myeloid cells in males and CD45+CD3+CD4+ lymphocytes in females. DRG neurons from male uPA-CBP mice exhibited heightened action potential firing. Pharmacological …

Go to article

Targeting The Beiging Of Muscle-Associated Adipose Tissue To Promote Muscle Regeneration, Jacob C. Parson May 2025

Targeting The Beiging Of Muscle-Associated Adipose Tissue To Promote Muscle Regeneration, Jacob C. Parson

WUSM Theses and Dissertations – All Programs

The expansion of intra-muscular adipose tissue (IMAT) between myofibers and epi-muscular adipose tissue (EMAT) outside of the muscle boundary accompanies numerous pathologies including diabetes, muscular dystrophy, and aging. IMAT and EMAT are anatomically juxtaposed to myofibers. Some evidence supports that IMAT and EMAT impede muscle function. This is potentially due to paracrine factors that are secreted by IMAT/EMAT. Different adipose depots can be classified in numerous ways including where they are located anatomically as well as the factors in which they secrete. Unlike classical white fat, adipose depots classified as brown or beige, noted by the marker uncoupling protein-1 (UCP-1) …

Go to article

Long-Term Efficacy Of Pembrolizumab And The Clinical Utility Of Ctdna In Locally Advanced Dmmr/Msi-H Solid Tumors, Michael Lapelusa, Wei Qiao, Bryan Iorgulescu, Francis San Lucas, Keyur Patel, Deepak Bhamidipati, Jane Varkey Thomas, Nancy You, Wai Chin Foo, Dipen Maru, Selvi Thirumurthi, Van Morris, Scott Kopetz, Michael Overman, Kaysia Ludford May 2025

Long-Term Efficacy Of Pembrolizumab And The Clinical Utility Of Ctdna In Locally Advanced Dmmr/Msi-H Solid Tumors, Michael Lapelusa, Wei Qiao, Bryan Iorgulescu, Francis San Lucas, Keyur Patel, Deepak Bhamidipati, Jane Varkey Thomas, Nancy You, Wai Chin Foo, Dipen Maru, Selvi Thirumurthi, Van Morris, Scott Kopetz, Michael Overman, Kaysia Ludford

Faculty, Staff and Student Publications

Neoadjuvant immunotherapy can induce pathologic complete response (pCR) in patients with localized deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) tumors. The long-term outcomes of these patients are unknown, as is the clinical utility of measuring circulating tumor DNA (ctDNA). Follow-up was evaluated in patients enrolled in a phase II trial (NCT04082572) that evaluated the efficacy and safety of pembrolizumab in patients with localized dMMR/MSI-H tumors. The primary outcomes of this trial have previously been reported. 3-year EFS and OS rates were 80% (95% CI: 66% - 93%) and 94% (95% CI: 86% - 100%). Patients without detectable ctDNA after pembrolizumab had …

Go to article

Effects Of Cytochalasin D On Motor Function In Drosophila, Airyel Noguera May 2025

Effects Of Cytochalasin D On Motor Function In Drosophila, Airyel Noguera

Honors Theses

Actin proteins play an important role in microfilaments, one of the three components of the cytoskeleton of the cell. The actin protein is responsible for cellular functions such as with their role in neuromuscular junctions. The dynamics of these proteins can be further explored with manipulation of polymerization through the treatment of a biochemical drug, Cytochalasin D. This fungal toxin caps the ends of actin filaments, destabilizing them by inhibiting G- and F-actin monomers from binding. Treating Drosophila in their early embryonic stage with this drug after permeabilization can give insights on the importance of actin proteins at neuromuscular junctions …

Go to article

Experimentally Testing A Mechanism Of Urban Adaptation: Are Wild Catbirds Able To Immediately Adjust Their Song In Response To Urban Noise?, Eriberto Osorio May 2025

Experimentally Testing A Mechanism Of Urban Adaptation: Are Wild Catbirds Able To Immediately Adjust Their Song In Response To Urban Noise?, Eriberto Osorio

Masters Theses, 2020-current

Anthropogenic noise is loud and low-frequency (low-pitch) sound with frequencies spanning from 1-2.5 kHz in frequency. In noisy urban areas, many birds sing songs with higher minimum frequencies, which can avoid the masking effects of anthropogenic noise. However, the mechanism for an individual to alter spectral aspects of bird song in real time to avoid the masking effect of urban noise is unknown. Immediate flexibility is the ability a bird may use to shifts their song frequency or amplitude in response to noise fluctuations in the environment. Some species that sing higher frequency songs in noisy habitats are not able …

Go to article

Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz May 2025

Assessing The Effects Of Streptozotocin-Induced Hyperglycemia On Amyloid Beta Accumulation And Cognitive Behavior In A Mouse Model Of Alzheimer’S Disease-Related Pathology, Andrew Adonay Ortiz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is an irreversible and devastating neurodegenerative disease characterized by progressive synaptic, dendritic, glial, and neuronal loss, collectively leading to impairments in learning, memory, and deterioration of cognitive and behavioral functions. AD is the most common form of dementia accounting for 60-80% of all cases. AD affects approximately 7 million Americans and is the 6th leading cause of death in the US. Furthermore, by 2050, the US is projected to spend over $1.1 trillion on AD-related treatments. Pathological hallmarks of AD include beta-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs), and chronic neuroinflammation, which can promote and exacerbate both …

Go to article

Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr May 2025

Detection And Quantification Of Total Airborne Fungi And Coccidioides Species In Environmental Samples, Theresa T. Roehr

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fungal exposure can cause acute and chronic illnesses or exacerbate existing illnesses. Some fungi are opportunistic pathogens and can lead to serious systemic fungal infections. In 2020, more than 150 million cases of severe fungal infections were reported globally resulting in an estimated 1.7 million deaths. Coccidioidomycosis, or Valley fever, is classified as a serious fungal infection caused by the fungi Coccidioides immitis and C. posadasii. These particular fungi are prevalent in the soil of the Southwestern United States, including Las Vegas, Nevada. In 2024, there were a total of 269 cases of Valley fever reported in Nevada, and …

Go to article

Emerging Adult Gamers: Nutritional Insights On Dietary Intake, Physical Well-Being, And Occupational Performance, Justine Dualan Tuason May 2025

Emerging Adult Gamers: Nutritional Insights On Dietary Intake, Physical Well-Being, And Occupational Performance, Justine Dualan Tuason

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study aimed to gather insights from Emerging Adult (EA) gamers (between 18 and 24) regarding their nutritional literacy, dietary patterns, and its potential impacts on their occupational performance and physical well-being. There is a need to gather gamers' perspectives to identify the specific facilitators and barriers regarding their ability to discern appropriate dietary choices, as it provides more information regarding preventative and client-centered measures for future healthcare professionals. Occupational Therapists (OTs) are uniquely equipped to address this population's needs, as the profession's holistic principles allow for a well-rounded and sustainable approach. Additionally, growing emphasis is placed on preventative rather …

Go to article

The Roles Of Oprf In Pseudomonas Aeruginosa Biofilms, Erin K. Cassin May 2025

The Roles Of Oprf In Pseudomonas Aeruginosa Biofilms, Erin K. Cassin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many bacteria form multicellular communities known as biofilms. Biofilms contain bacterial cells and a protective extracellular biofilm matrix. This matrix contains exopolysaccharides, extracellular DNA (eDNA), membrane vesicles, and proteins. The matrix proteins are far less characterized than other extracellular biofilm components. In biofilms formed by the model organism Pseudomonas aeruginosa, the protein OprF is abundant in the cellular outer membrane and the extracellular matrix. In my dissertation research, I have presented data supporting the hypothesis that the OprF protein significantly affects P. aeruginosa biofilms. By examining various strain backgrounds and the nutrient-dependent effects of glucose and sodium chloride, I demonstrate …

Go to article

Using Neural Networks To Better Understand Static And Dynamic Components Of Facial Expression Recognition, Yi-Fan Li, Anne Bibiana Sereno May 2025

Using Neural Networks To Better Understand Static And Dynamic Components Of Facial Expression Recognition, Yi-Fan Li, Anne Bibiana Sereno

MODVIS Workshop

Facial expressions are crucial social information for human communication. In the real world, facial expressions are dynamic; however, much of existing research in facial expressions relies on static stimuli. This static approach may limit the ecological validity of our understanding of the emotional information on faces. Our study aims to investigate the dynamic and static information contained in different emotional categories of facial expressions (e.g., happy, sad). Four convolutional neural networks are introduced as models to be trained with a large-scale dynamic facial expression dataset (short videoclips of 16 frames of 7 different emotional categories) in four different ways: ordered …

Go to article

Tropical Forest Soil Microbiome Modulates Leaf Heat Tolerance More Strongly Under Warming Than Ambient Conditions, Gabriela Hernandes Villani, Iana F. Grullón-Penkova, Parker Bartz, Joel Masanga, Jesse R. Lasky, Molly A. Cavaleri, Tana E. Wood, Benedicte Bachelot May 2025

Tropical Forest Soil Microbiome Modulates Leaf Heat Tolerance More Strongly Under Warming Than Ambient Conditions, Gabriela Hernandes Villani, Iana F. Grullón-Penkova, Parker Bartz, Joel Masanga, Jesse R. Lasky, Molly A. Cavaleri, Tana E. Wood, Benedicte Bachelot

Michigan Tech Publications

It is unclear how plants respond to increasing temperatures. Leaf heat tolerance (LHT) is often at its upper limit in tropical forests, suggesting that climate change might negatively impact these forests. We hypothesized that intraspecific variation in LHT might be associated with changes in the soil microbiome, which might also respond to climate. We hypothesized that warming would increase LHT through changes in the soil microbiome: we combined an in situ tropical warming experiment with a shade house experiment in Puerto Rico. The shade house experiment consisted of growing seedlings of Guarea guidonia, a dominant forest species, under different soil …

Go to article

North Central Extension Risk Management Education Center, Part Ii: Outcomes And Impacts: Empowering Farmers, Transforming Futures, Sheila Aikanathan Johnson, Christine Lockert, Bradley D. Lubben May 2025

North Central Extension Risk Management Education Center, Part Ii: Outcomes And Impacts: Empowering Farmers, Transforming Futures, Sheila Aikanathan Johnson, Christine Lockert, Bradley D. Lubben

Cornhusker Economics

The North Central Extension Risk Management Education Center remains dedicated to helping American farmers and ranchers manage the unique risks of producing food for a global market. To date, we have funded 545 projects totaling over $20 million, reaching more than 175,500 participants. Collaboratively, these efforts reflect a growing commitment to equipping producers with the tools, knowledge, and support needed to make informed decisions, strengthen resilience, and ensure the long-term sustainability of agriculture across our region and beyond.

Go to article

Quantifying 14 Years Of Restoration Impact At A Los Angeles Park Using Remote Sensing, Alexa Siglar, Demian A. Willette May 2025

Quantifying 14 Years Of Restoration Impact At A Los Angeles Park Using Remote Sensing, Alexa Siglar, Demian A. Willette

Honors Thesis

Ascot Hills Park is an urban park in the El Sereno neighborhood of east Los Angeles that has undergone continuous restoration efforts to reintroduce California native trees and shrubs from 2011-2025. This study seeks to understand how a 14 year period of continuous restoration by a variety of stakeholders has changed the park by asking the following question: How has native plant cover changed over time? To answer this question, the change in percent native plant cover at the park from 2011-2025 was quantified using satellite imagery and machine learning software in ArcGIS Pro. Satellite images and ArcGIS Pro were …

Go to article

Empowering Precision Agriculture With The Internet Of Things, Artificial Intelligence, And Robotics, Adarsha Neupane, Vidya Samadi May 2025

Empowering Precision Agriculture With The Internet Of Things, Artificial Intelligence, And Robotics, Adarsha Neupane, Vidya Samadi

Forestry and Natural Resources

As the global population grows, agriculture faces increasing demands for higher productivity and sustainability. The incorporation of advanced technologies such as Artificial Intelligence (AI), Internet of Things (IoT), and robotics is revolutionizing farming by improving efficiency, enhancing decision-making, and promoting sustainability through optimized resource use. This publication provides insights into the implementation of these smart farming solutions and their benefits for farmers, crop consultants, and stakeholders. It also addresses the challenges of adopting these technologies, highlighting their crucial role in meeting future food demands sustainably.

Go to article

How Soil Fungal Communities Respond To Invasive Plant Species Treatments In Soil From Banksia Woodland, South-Western Australia, Aaron J. Brace, Katinka X. Ruthrof, Joseph B. Fontaine, Ben P. Miller, Anna J.M. Hopkins May 2025

How Soil Fungal Communities Respond To Invasive Plant Species Treatments In Soil From Banksia Woodland, South-Western Australia, Aaron J. Brace, Katinka X. Ruthrof, Joseph B. Fontaine, Ben P. Miller, Anna J.M. Hopkins

Research outputs 2022 to 2026

Context. Invasive plants are one of the most significant threats to woodlands globally. Methods of invasive plant control include manual removal and herbicide application. While the impacts of control methods on invasive and off-target native plant species are often explored, the impacts on below-ground organisms, such as fungi, are less well understood. Aims. We conducted a glasshouse trial to investigate the responses of soil fungal communities to herbicides and manual removal that are used to control common invasive plant species in Banksia woodland in south-western Australia. Methods. Broad spectrum (glyphosate and pelargonic acid) and grass-specific (fluazifop-p-butyl) herbicides were separately applied …

Go to article

Chronic Inflammation: The Link Between A High Added Sugar Diet And Disease, Anna Collins May 2025

Chronic Inflammation: The Link Between A High Added Sugar Diet And Disease, Anna Collins

Senior Honors Theses

The modern diet includes many processed foods that contain added sugars, resulting in a significant increase in daily glucose and fructose consumption. Considering this, there is an increased effort to uncover the effects of excess sugar intake on the body’s health and metabolism. Strong evidence supports the connection between a high added sugar diet and the presence of chronic, low-grade inflammation due to cellular distress and metabolic dysfunction. Prolonged inflammatory responses are linked to tissue damage and the development of various metabolic diseases that are prevalent in modern society, such as obesity, fatty liver disease, cardiovascular disease, and type 2 …

Go to article

Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Pereira, Rupesh Kariyat May 2025

Biochar Suppresses Growth, Pupation And Eclosion Success Of A Specialist (Manduca Sexta) And A Generalist (Spodoptera Frugiperda) Insect Herbivore, Nischal Wagle, Soumya Unnikrishnan, Satinderpal Kaur, Engil Pereira, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Biochar is a charcoal-like substance made by the pyrolysis of organic material from agricultural and forestry waste. While biochar is well documented for altering soil physicochemical conditions, few studies have investigated its possible effects on the management of arthropod pests. Tobacco hornworm (Manduca sexta) and fall armyworm (Spodoptera frugiperda, FAW) are specialist and generalist insect herbivores respectively, that can cause significant defoliation in natural and agricultural ecosystems. In this study, we examined whether walnut shell biochar can affect growth and development of these herbivores. Specifically, we investigated how biochar influences parameters such as mass gain, length of pupation, pupal mass, …

Go to article

Ogg1s326c Variant Frequent In Human Populations Facilitates Inflammatory Responses Due To Its Extended Interaction With Dna Substrate, Jinling Han, Meichen Zhang, Jiakun Ge, Zhihua Ji, Jianyi Zhao, Yinchao Hu, Chunshuang Li, Yaoyao Xue, Xining Li, Haiwang Zhao, Zixu Cui, Miaomiao Tian, Xu Zheng, Dapeng Wang, Jing Wang, Min Wei, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba May 2025

Ogg1s326c Variant Frequent In Human Populations Facilitates Inflammatory Responses Due To Its Extended Interaction With Dna Substrate, Jinling Han, Meichen Zhang, Jiakun Ge, Zhihua Ji, Jianyi Zhao, Yinchao Hu, Chunshuang Li, Yaoyao Xue, Xining Li, Haiwang Zhao, Zixu Cui, Miaomiao Tian, Xu Zheng, Dapeng Wang, Jing Wang, Min Wei, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba

Faculty, Staff and Student Publications

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant hOGG1S326C, prevalent in Caucasians and Asians, has been regarded as a susceptibility factor for various diseases, yet its pathogenic mechanism remains elusive. In this study, we demonstrate that Ogg1S326C/S326C mice exhibit increased and sustained airway inflammation compared with wild-type (WT) Ogg1S326/S326 mice. Mechanistically, in response to inflammatory stimulation, OGG1S326C undergoes reactive oxygen species-induced dimerization, which impairs its base excision function, but …

Go to article

Phase I Study Of Pomalidomide In Relapsed Or Refractory Waldenström Macroglobulinaemia, Karan L Chohan, Donna M Weber, Lei Feng, L Michael Wang, Sattva S Neelapu, Jasper Olsem, Ralph J Johnson, Claudia Morales De Partovi, Robert Z Orlowski, Sheeba K Thomas May 2025

Phase I Study Of Pomalidomide In Relapsed Or Refractory Waldenström Macroglobulinaemia, Karan L Chohan, Donna M Weber, Lei Feng, L Michael Wang, Sattva S Neelapu, Jasper Olsem, Ralph J Johnson, Claudia Morales De Partovi, Robert Z Orlowski, Sheeba K Thomas

Faculty, Staff and Student Publications

No abstract provided.

Go to article

Common Challenges Faced By Early-Career Researchers In Latin American And Small U.S. Universities, Daniela Cejas, Fatima Rodriguez Acosta, Juan Rivera-Correa May 2025

Common Challenges Faced By Early-Career Researchers In Latin American And Small U.S. Universities, Daniela Cejas, Fatima Rodriguez Acosta, Juan Rivera-Correa

Publications and Research

Early-career researchers from Spanish-speaking Latin American countries and small U.S. universities are underrepresented in international scientific databases. They have geographical importance, infectious disease endemicity, and exceptional researchers in microbiology, but these factors do not translate to representation in high-impact scientific publications. Many reasons could be involved, including financial burdens such as the inability to pay article processing charges. Additional teaching, institutional, and service responsibilities also highly influence their research productivity. Despite this, they are expected to publish high-impact articles, and their career development highly depends on it. There is an opportunity for global peer collaboration to tackle this inequity and …

Go to article

In The Quest For New Horizons: Evaluating Novel Therapeutic Approaches For Tuberculosis Treatment, Selassie Mawuko, Aminata Traore, Bibi-Sakeena Khemraj, Anna Steto, Richa Gupta May 2025

In The Quest For New Horizons: Evaluating Novel Therapeutic Approaches For Tuberculosis Treatment, Selassie Mawuko, Aminata Traore, Bibi-Sakeena Khemraj, Anna Steto, Richa Gupta

Publications and Research

Tuberculosis (TB) in humans, caused by Mycobacterium tuberculosis, is a significant global health concern, resulting in high disease burden and mortality each year which together make it the world’s topmost infectious killer. The emergence of multidrug-resistant tuberculosis (MDR-TB) in recent decades has further exacerbated the present situation and warrants an urgent need to develop and investigate innovative treatment regimes. This study aims to assess the therapeutic potential of newly identified drug candidates, namely Bedaquiline, Delamanid, and Linezolid, in treating MDR-TB. We adopted a consolidated and integrated approach encompassing a thorough literature review, empirical experimental studies, multiple sequence alignments, and …

Go to article

The Investigation Of Lateral Foraging Patterns In Fin And Sei Whales, Alex Eschmann May 2025

The Investigation Of Lateral Foraging Patterns In Fin And Sei Whales, Alex Eschmann

Theses - ALL

Lateralization is the specialization that enhances an organism’s survival by dedicating specific tasks to the hemispheres of the brain, strengthening neural pathways to enhance speed and dexterity of task performance. First described in humans in 1861, lateralization has also been observed in non-human organisms where it often plays a critical role in predator-prey dynamics. Lateralized behaviors for prey foraging, social interactions, and communication have been described in some species of marine mammals from across all three distinct taxonomic orders. In the Order Cetacea, toothed and baleen whale species exhibit lateralized foraging behaviors for prey capture. In this study, I investigated …

Go to article

Designing An Economically Viable Off-Grid Photovoltaic System Considering The Battery Discharge Rate, Ahmed S. Abdelrazek, Eslam Mohamed Ahmed, Mahmoud Elsisi, Mokhtar Said May 2025

Designing An Economically Viable Off-Grid Photovoltaic System Considering The Battery Discharge Rate, Ahmed S. Abdelrazek, Eslam Mohamed Ahmed, Mahmoud Elsisi, Mokhtar Said

Mansoura Engineering Journal

The primary significance of harnessing power from clean and renewable sources lies in the fact that numerous rural areas are far from the utility system. Among the renewable energy technologies catering to power needs in residential areas is the solar photovoltaic (PV) system. Despite the potential of PV technology and the abundant sun radiation exposure in Hurghada, Egypt, there is a lack of empirical studies evaluating the feasibility of off-grid power production using this system. A notable aspect of this study is the consideration of the discharge rate of the battery for sizing the off-grid system, involving the distribution of …

Go to article

First Prev Next Last