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Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li Jan 2026

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …


A Quantitative Analysis Examining The Impact Of Recreation Sports On The Overall Wellness Of Undergraduate Students At The University Of Louisiana At Lafayette, Kathryn "K-Lynn" Mckey Jan 2026

A Quantitative Analysis Examining The Impact Of Recreation Sports On The Overall Wellness Of Undergraduate Students At The University Of Louisiana At Lafayette, Kathryn "K-Lynn" Mckey

Doctoral Dissertations

The overarching question guiding this research study was, how does the use of university recreational sports facilities and resources impact reported wellness across the eight dimensions of wellness among undergraduate students? This study answered this question by examining literature, reviewing specific dimensions of wellness, and evaluating ways to determine if physical activity affects overall wellness for undergraduate students. According to the literature, approximately half of undergraduate students do not meet the daily recommendation for physical activity. Research suggests healthier students have greater retention rates, higher grade point averages (GPA), and demonstrate better mental health. To better support students’ needs, universities …


A194: Examining The Cultivation Paths And Practical Strategies Of National Community Consciousness Through Rural Sports Events, Yicheng Wang Jan 2026

A194: Examining The Cultivation Paths And Practical Strategies Of National Community Consciousness Through Rural Sports Events, Yicheng Wang

International Journal of Physical Activity and Health

National community consciousness is fundamental for national stability and ethnic unity. Rural sports events, an integral part of rural cultural life, play a crucial role in promoting this consciousness. Amidst the push for rural revitalization and cultural preservation, this study aims to clarify how rural sports events enhance national community consciousness. Through a comprehensive literature review, it offers theoretical support for fostering rural ethnic harmony and cultural prosperity. Method: was conducted. Databases like CNKI, Wanfang, VIP, Web of Science, and EBSCO were searched using keywords such as "rural sports events", "national community consciousness", and "ethnic cultural exchanges" for literature in …


A278: The Effects Of Mtm-Based Stepped Behavior Change Intervention On Sedentary Lifestyle Among Community-Dwelling Older Adults, Subinuer Tuerdi, Yuewei Li Jan 2026

A278: The Effects Of Mtm-Based Stepped Behavior Change Intervention On Sedentary Lifestyle Among Community-Dwelling Older Adults, Subinuer Tuerdi, Yuewei Li

International Journal of Physical Activity and Health

Sedentary lifestyles are prevalent in the life patterns of community-dwelling older adults, who have been shown to be the most sedentary and physically inactive subgroup. Prolonged low energy expenditure during waking hours leads to an increased risk of non-communicable diseases and impairs physical functioning in older adults, negatively impacting their health outcomes. Therefore, interventions targeting changes in sedentary lifestyles are necessary to improve health behaviors in older adults. An experimental study was conducted to verify whether a sedentary lifestyle modification intervention based on the Multi-Theory Mode(MTM)and the staircase approach is more effective than conventional education in reducing sedentary time and …


A282: The Impact Of Creative Dance On The Urban Integration Of Migrant Children In China, Xin Lin, Qiaoyi Liang Jan 2026

A282: The Impact Of Creative Dance On The Urban Integration Of Migrant Children In China, Xin Lin, Qiaoyi Liang

International Journal of Physical Activity and Health

Migrant children represent a unique demographic emerging from China's rapid urbanization. Due to disparities in public resource allocation, socioeconomic conditions, and prolonged exposure to unstable living environments, these children often face significant emotional and social challenges. When confronted with conflicts between urban and rural lifestyles and behavioral norms, they are prone to feelings of inferiority and anxiety, leading to communication barriers and social marginalization, hindering their timely integration into urban society. Creative dance emphasizes interpersonal interaction and engagement as an embodied intervention integrating both physical activity and artistic expression. It plays a crucial role in fostering social support networks and …


A295: Creating The Huxiang Sports Digital Museum: Pathways And Cultural Empowerment, Zhao Mei Jan 2026

A295: Creating The Huxiang Sports Digital Museum: Pathways And Cultural Empowerment, Zhao Mei

International Journal of Physical Activity and Health

Hunan sports culture boasts a profound heritage, encompassing traditional sports intangible cultural heritage, folk competitions, and festive customs. However, traditional preservation methods face digital challenges, such as monotonous display formats, insufficient interactivity, and limited dissemination channels. With the advancement of China's cultural digitization strategy, digital technologies have provided new pathways for the preservation, innovation, and dissemination of sports cultural heritage. Nevertheless, the Hunan region still requires systematic exploration in areas like the integration of sports intangible cultural heritage resources, digital platform development, and international communication Method: The study employ a comprehensive methodology integrating literature analysis, case studies, and field research, …


A067: Improving Children's Community-Based Sports Coaching Service Quality: An Sor Model Analysis, Xiaozhe Yang, Chenglong Wang, Lei Zhang Jan 2026

A067: Improving Children's Community-Based Sports Coaching Service Quality: An Sor Model Analysis, Xiaozhe Yang, Chenglong Wang, Lei Zhang

International Journal of Physical Activity and Health

In recent years, children’s community-based sports coaching has experienced rapid growth due to its convenience, safety, and tailored approach. However, parents’ trust in the quality of coaching services significantly impacts development. This study, grounded in the stimulus-organism-response (SOR) model, examines how service quality (stimulus) influences parental trust (organism) and their intention to utilize such services (response) from the perspective of parental trust. It analyzes existing service issues and proposes measures to enhance service quality, offering practical guidance for institutions and coaches. Method: This study combined the use of questionnaires and semi-structured interviews. First, questionnaires were distributed to 300 parents to …


A250: Children's Volleyball For Health And Transition From Kindergarten To Primary School Under New Curriculum Standards, Qiming Zhu, Yuang Wang, Fang Yuan, Qingyi Wu Jan 2026

A250: Children's Volleyball For Health And Transition From Kindergarten To Primary School Under New Curriculum Standards, Qiming Zhu, Yuang Wang, Fang Yuan, Qingyi Wu

International Journal of Physical Activity and Health

In early childhood sports education, health promotion, and the seamless connection between early childhood and primary school sports are critical issues. Early childhood represents a pivotal stage for children's physical development, during which volleyball can significantly enhance teamwork, coordination, and overall fitness. Despite growing research interest in this area, significant gaps remain in leveraging early childhood volleyball as a tool for promoting health and ensuring a smooth transition from early childhood to primary school sports. Documentation Research Method: Review literature for research status and theoretical support. Questionnaire Survey Method: Survey teachers, parents, and children on early childhood volleyball and transition …


A305: The International Communication Path Of Table Tennis Sports Presentation, Mingchen Xu, Xiyu Zhao Jan 2026

A305: The International Communication Path Of Table Tennis Sports Presentation, Mingchen Xu, Xiyu Zhao

International Journal of Physical Activity and Health

Table tennis carries a unique mission of cross-cultural communication. In 1971, the "Ping-Pong Diplomacy" with the strategic wisdom of "a small ball turning a big ball" set a classic model for sports public diplomacy. As a carrier of national cultural symbols, the international communication of table tennis should rely on major events to tell the table tennis story to achieve presentation and Presentation. As a key for event communication, in table tennis events, is driven by the synergy of three-dimensional elements: "competitive core + technological extension + commercial drive". Specifically, through the organic combination of visual and auditory elements and …


A080: Research On Intelligent Practical Path Of Extracurricular Sports Models In The Context Of Ai Empowerment, Ye Wu Jan 2026

A080: Research On Intelligent Practical Path Of Extracurricular Sports Models In The Context Of Ai Empowerment, Ye Wu

International Journal of Physical Activity and Health

This study aims to explore and optimize the "teaching, practicing, and competing" sports teaching model by integrating artificial intelligence (AI) technology. It focuses on building a new intelligent ecosystem for sports education, emphasizing the connection between "teaching," the bridging role of "practicing," and the efficiency of "regular competition" to enhance students' sports skills and literacy. Through AI, the study enables personalized teaching content, intelligent practice feedback, and automated competition management. This approach provides innovative ideas and theoretical support for school physical education, promotes the deep integration of "learning, practicing, and competing," and strengthens school sports education in the new era. …


A131: Swot And Strategic Of Event Operation Under The Background Of Electronic Sports Entering The Olympics, Shenghe Yang, Changhao Liu, Hongyu Chen, Feitao Xu Jan 2026

A131: Swot And Strategic Of Event Operation Under The Background Of Electronic Sports Entering The Olympics, Shenghe Yang, Changhao Liu, Hongyu Chen, Feitao Xu

International Journal of Physical Activity and Health

The inclusion of esports in the Olympics presents new opportunities and challenges for event operations. While enhancing industry recognition and attracting policy support and capital investment, it also faces issues with traditional sports concepts and insufficient standardization of event rules. This study focuses on a SWOT analysis of esports event operations to identify competitive advantages and potential risks, aiming to provide strategic insights for sustainable development. This study employs the SWOT analysis model, integrating literature analysis, case studies, and data statistics to evaluate the internal and external environments of esports event operations. Data sources include industry reports, typical event cases …


A133: Self-Aggrandizing In Badminton Teaching Short Videos Affects Learning Willingness, Mingxiang Yi, Yuanjing Huang Jan 2026

A133: Self-Aggrandizing In Badminton Teaching Short Videos Affects Learning Willingness, Mingxiang Yi, Yuanjing Huang

International Journal of Physical Activity and Health

Based on the new era of digital sports development, self-media platforms have become an important carrier of sports teaching communication; however, few studies have investigated the relationship between self-aggrandizing behavior during sports teaching on self-media platforms and platform users' learning intention. In this study, we take Jittery self-media platform as an example to explore the chain path that creators' boasting behavior (H1) positively affects users' learning intention (H2) by enhancing users' trust (H3), and to verify the mediating effect of trust in the relationship between boasting behavior and learning intention, as well as the two-way influence between badminton short video …


A211: Ai-Driven Strategic Frameworks For Sport Event Propagation Under Media Affordance Theory, Wenqian Yao, Jingwang Zhang Jan 2026

A211: Ai-Driven Strategic Frameworks For Sport Event Propagation Under Media Affordance Theory, Wenqian Yao, Jingwang Zhang

International Journal of Physical Activity and Health

The advancement of intelligent technology has transformed interaction models across communication ecosystems, encompassing production, dissemination, and consumption. Exemplified by the Paris Olympics’ 180+ intelligent communication domains, “AI + Sports” has emerged as an industry paradigm. This study employs media affordance theory to analyze AI’s transformative role in sports communication and associated ethical challenges, offering insights for cultivating a robust digital sports ecosystem. Method: This study investigates the application pathways of artificial intelligence in 20 major sports events held between 2000 and 2024. Data on application frequency, audience feedback, and other relevant metrics w collected to analyze the impact patterns of …


A228: Preservation And Dissemination Of Taijiquan Culture In Digital Perspective, Songqi Wang, Bin Yan Jan 2026

A228: Preservation And Dissemination Of Taijiquan Culture In Digital Perspective, Songqi Wang, Bin Yan

International Journal of Physical Activity and Health

One of China’s most iconic cultural traditions has increasingly gained: Taijiquned global recognition: Taijiquned. However, rapid digitalization has significantly changed young people's cultural preferences and participation habits, posing challenges to traditional methods of cultural preservation, which often fail to resonate with youth, creating a noticeable disconnect. This study examines the potential of digital communication—especially short videos, livestreaming, and social media—to preserve and disseminate Taijiquan culture through interactive, youth-oriented methods. Specifically, it empirically explores whether digital media strategies effectively improve younger generations’ cultural awareness, participation motivation, and cultural identity, aiming to provide practical insights for digital heritage protection. A randomized controlled …


Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez Jan 2026

Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez

Faculty, Staff and Student Publications

Dietary components influence microbial composition in the digestive tract. Although often viewed as energy sources, dietary components are likely to shape microbial determinants of intestinal colonization beyond metabolism. Here, we report that a dietary long-chain fatty acid enhances the yeast Candida albicans colonization of the murine gut partly by eliciting modifications to the fungal cell surface. Mice fed an oleic acid-rich diet were readily colonized by C. albicans and exhibited higher fungal load in feces compared with rodents fed an isocaloric control diet. Surprisingly, β-oxidation, a catabolic process to break down fatty acids for energy production, was dispensable for C. …


The Food Ethics, Sustainability And Alternatives Course: A Mixed Assessment Of University Students’ Readiness For Change, Charles Feldman, Stephanie A. Navarro Silvera Jan 2026

The Food Ethics, Sustainability And Alternatives Course: A Mixed Assessment Of University Students’ Readiness For Change, Charles Feldman, Stephanie A. Navarro Silvera

Department of Nutrition and Food Studies Scholarship and Creative Works

Growing interest in food sustainability education aims to increase awareness of food distribution systems, environmental degradation, and the connectivity of sustainable and ethical food practices. However, recent scholarship has questioned whether such pedagogical efforts are meaningfully internalized by students or lead to sustained behavioral change. Prior studies document persistent gaps in students’ understanding of sustainability impacts and the limited effectiveness of existing instructional approaches in promoting transformative engagement. To address these concerns, the Food Ethics, Sustainability and Alternatives (FESA) course was implemented with 21 undergraduate and graduate students at Montclair State University (Montclair, NJ, USA). Course outcomes were evaluated using …


Investigating Host Factors In Coronavirus Assembly And Egress, Surovi Binte Sharmin Mohona Jan 2026

Investigating Host Factors In Coronavirus Assembly And Egress, Surovi Binte Sharmin Mohona

Dissertations

Coronavirus (CoV) structural proteins congregate at the ER-Golgi intermediate compartments (ERGIC) prior to virus budding into the organelle lumen. Subsequent trafficking and fusion of virus-containing, ERGIC-derived vesicles then release nascent viruses from infected cells. Our findings in this dissertation illuminate mechanisms by which CoV structural proteins coalesce at the virus assembly and budding sites. The cytoplasmic tails of all CoV spike (S) glycoproteins contain variants of a consensus KxKxx coatomer-binding motif. Host coatomer complexes facilitate retrograde trafficking of client cargo proteins via recognition of such motifs. Utilizing reverse genetics methodologies, we introduced variations in the S coatomer motif in a …


Genome-Wide Gene By Sleepiness Interaction Analysis For Sleep Apnea, Pavithra Nagarajan, Nuzulul Kurniansyah, Jiwon Lee, Sina A Gharib, Yushan Xu, Yiyan Zhang, Brian Spitzer, Tariq Faquih, Hufeng Zhou, Eric Boerwinkle, Han Chen, Daniel J Gottlieb, Xiuqing Guo, Nancy L Heard-Costa, Bertha A Hidalgo, Daniel Levy, Peter Y Liu, Hao Mei, Rebecca Montalvan, Sutapa Mukherjee, Kari E North, George T O'Connor, Lyle J Palmer, Sanjay R Patel, Bruce M Psaty, Shaun M Purcell, Laura M Raffield, Stephen S Rich, Jerome I Rotter, Richa Saxena, Albert V Smith, Katie L Stone, Xiaofeng Zhu, Topmed Sleep Trait Working Group, Brian E Cade, Tamar Sofer, Susan Redline, Heming Wang Jan 2026

Genome-Wide Gene By Sleepiness Interaction Analysis For Sleep Apnea, Pavithra Nagarajan, Nuzulul Kurniansyah, Jiwon Lee, Sina A Gharib, Yushan Xu, Yiyan Zhang, Brian Spitzer, Tariq Faquih, Hufeng Zhou, Eric Boerwinkle, Han Chen, Daniel J Gottlieb, Xiuqing Guo, Nancy L Heard-Costa, Bertha A Hidalgo, Daniel Levy, Peter Y Liu, Hao Mei, Rebecca Montalvan, Sutapa Mukherjee, Kari E North, George T O'Connor, Lyle J Palmer, Sanjay R Patel, Bruce M Psaty, Shaun M Purcell, Laura M Raffield, Stephen S Rich, Jerome I Rotter, Richa Saxena, Albert V Smith, Katie L Stone, Xiaofeng Zhu, Topmed Sleep Trait Working Group, Brian E Cade, Tamar Sofer, Susan Redline, Heming Wang

Faculty, Staff and Student Publications

Study objectives: Excessive daytime sleepiness (EDS), influenced by environmental and social-behavioral factors, is reported by a subset of patients with sleep apnea-a group that may be at elevated cardiovascular risk. However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-by-EDS interaction analyses for apnea hypopnea index, a diagnostic marker of sleep apnea severity, to understand EDS's influence on its underlying genetic risk.

Methods: Discovery interaction analyses for common variants and gene-based rare variants were conducted respectively using multi-ethnic Trans-Omics for Precision Medicine (N = 11 619) data, followed by …


Workflow Improvements From Automated Large Vessel Occlusion Detection Algorithms Are Dependent On Care Team Engagement, Emmanuel C Ebirim, Ngoc Mai Le, Joseph N Samaha, Hussain Azeem, Ananya Iyyangar, Anjan N Ballekere, Saagar Dhanjani, Luca Giancardo, Eunyoung Lee, Sunil A Sheth Jan 2026

Workflow Improvements From Automated Large Vessel Occlusion Detection Algorithms Are Dependent On Care Team Engagement, Emmanuel C Ebirim, Ngoc Mai Le, Joseph N Samaha, Hussain Azeem, Ananya Iyyangar, Anjan N Ballekere, Saagar Dhanjani, Luca Giancardo, Eunyoung Lee, Sunil A Sheth

Faculty, Staff and Student Publications

Background: Automated machine learning (ML)-based large vessel occlusion (LVO) detection algorithms have been shown to improve in-hospital workflow metrics including door-to-groin time (DTG). The degree to which care team engagement and interaction are required for these benefits remains incompletely characterized.

Methods: This analysis was conducted as a pre-planned post-hoc analysis of a randomized prospective clinical trial. ML-based LVO detection software was implemented at four comprehensive stroke centers (CSCs) from January 1, 2021, to February 27, 2022. Patients were included if they underwent endovascular thrombectomy for LVO acute ischemic stroke. ML software utilization was quantified as the total number of active …


Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy Jan 2026

Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy

Theses and Dissertations

The Caenorhabditis genus produced three independently-evolved hermaphroditic species, C. elegans, C. briggsae, and C. tropicalis. This convergence happened by the independent co-option of male programs for use in a female body. This required two distinct steps: (1) mutations in the sex-determination pathway that activated spermatogenesis in XX animals, and (2) mutations that expressed one of the redundant sperm activation signals in XX animals. My project focused on characterizing how sex-determination genes work in C. briggsae and C. tropicalis. Loss-of-function alleles were used to compare the core sex-determination pathway to that of C. elegans. I found that the somatic sex-determination pathway …


Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman Jan 2026

Tumor-Infiltrating Bacteria Disrupt Cancer Epithelial Cell Interactions And Induce Cell-Cycle Arrest, Jorge Luis Galeano Niño, Falk Ponath, Victor A Ajisafe, Clara R Becker, Andrew G Kempchinsky, Martha A Zepeda-Rivera, Javier A Gomez, Hanrui Wu, Jessica G Terrazas, Heather Bouzek, Elizabeth Cromwell, Pritha Chanana, Matthew Wong, Ashish Damania, Michael G White, Y Nancy You, Scott Kopetz, Nadim J Ajami, Jennifer A Wargo, Christopher D Johnston, Susan Bullman

Faculty, Staff and Student Publications

Tumor-infiltrating bacteria are increasingly recognized as modulators of cancer progression and therapy resistance. We describe a mechanism by which extracellular intratumoral bacteria, including Fusobacterium, modulate cancer epithelial cell behavior. Spatial imaging and single-cell spatial transcriptomics show that these bacteria predominantly localize extracellularly within tumor microniches of colorectal and oral cancers, characterized by reduced cell density, transcriptional activity, and proliferation. In vitro, Fusobacterium nucleatum disrupts epithelial contacts, inducing G0-G1 arrest and transcriptional quiescence. This state confers 5-fluorouracil resistance and remodels the tumor microenvironment. Findings were validated by live-cell imaging, spatial profiling, mouse models, and a 52-patient colorectal cancer cohort. Transcriptomics reveals …


Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang Jan 2026

Spatial Omics At The Forefront: Emerging Technologies, Analytical Innovations, And Clinical Applications, Yunhe Liu, Yibo Dai, Linghua Wang

Faculty, Staff and Student Publications

Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems with unprecedented fidelity. We highlighted analytical breakthroughs-including multimodal integration and emerging spatial foundation models-that resolve functional niches and spatial communities, converting spatial patterns into mechanistic insights. We summarize how spatially organized features, from immune hubs to microbiota and neural interfaces, shape tumor evolution and clinical outcomes. We then outline how spatial approaches illuminate precancer biology, metastatic adaptation, and therapy response. Bridging discovery and translation, we provide a …


Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through Sfrp4 Signaling, Joseph Rupert, Lingyi Cai, Alexes C Daquinag, Dimitris Anastassiou, Mikhail G Kolonin Jan 2026

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through Sfrp4 Signaling, Joseph Rupert, Lingyi Cai, Alexes C Daquinag, Dimitris Anastassiou, Mikhail G Kolonin

Faculty, Staff and Student Publications

Background/objectives: Progression of pancreatic ductal adenocarcinoma (PDAC) and other carcinomas relies on cancer-associated fibroblasts (CAFs). A subset of CAFs is derived from adipose stromal cells (ASCs) recruited by tumors and the ASC-CAF conversion has been associated with invasiveness and poor prognosis.

Methods: To explore the underlying molecular mechanisms, we used a model based on primary ASCs derived from human visceral adipose tissue co-cultured with human PDAC cell line Capan-1. To investigate cancer progression in vivo, we also used mice orthotopically grafted with mouse KPC cells.

Results: Genomic analysis revealed that Capan-1 co-culture induces Wnt and TGFβ signaling and extracellular matrix …


Changes In Phenology Mediate Vertebrate Population Responses To Temperature Globally, Viktoriia Radchuk, Carys V. Jones, Nina Mclean, Anne Charmantier, Céline Teplitsky, Ray Alisauskas, Sergio Ancona, Tycho Anker-Nilssen, Peter Arcese, Karl S. Berg Jan 2026

Changes In Phenology Mediate Vertebrate Population Responses To Temperature Globally, Viktoriia Radchuk, Carys V. Jones, Nina Mclean, Anne Charmantier, Céline Teplitsky, Ray Alisauskas, Sergio Ancona, Tycho Anker-Nilssen, Peter Arcese, Karl S. Berg

School of Integrative Biological & Chemical Sciences Faculty Publications

Phenotypic responses to climate affect individual fitness, but the extent to which this translates into effects on population dynamics remains poorly understood. We assemble 213 time series on phenotypes and population sizes of wild vertebrates globally and match them with local climate data. Our meta-analysis shows that morphological traits are mostly climate insensitive. However, phenology is earlier in warmer-than-average years, which contributes positively to population growth in most species. At lower latitudes, temperature has weaker effects on phenology but stronger direct negative effects on population growth, likely because these populations are less capable of tracking climate via plasticity. Variation in …


Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote Jan 2026

Proton Versus Photon Radiotherapy For Patients With Oropharyngeal Cancer In The Usa: A Multicentre, Randomised, Open-Label, Non-Inferiority Phase 3 Trial, Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W Mcdonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote

Faculty, Staff and Student Publications

Background: Radiotherapy is an integral component of treatment for oropharyngeal cancer. Toxicity from the current state-of-the-art photon radiotherapy, intensity-modulated radiation therapy (IMRT), has prompted the search for alternative, less toxic therapies. One such alternative that might de-intensify treatment is proton therapy. In this trial, we aimed to directly compare IMRT with intensity-modulated proton therapy (IMPT), both concurrent with systemic therapy, hypothesising comparable disease control and survival and lower toxicity.

Methods: This randomised, multicentre, open-label, non-inferiority, phase 3 trial was conducted in 21 sites (cancer centres or universities) in the USA. Patients (aged ≥18 years) with stage III or stage IV …


An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan Jan 2026

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …


Plants In An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök Jan 2026

Plants In An Aquaponics System, Amy M. Shambach, Rebecca M. Ward, J. Stuart Carlton, Kwamena K. Quagrainie, Tomas O. Höök

Supplementary Content for Aquaponics: Farming Fish and Growing Greens for Grades 9–12

This PowerPoint slide provides readers with information on plants in an aquaponics system. This book was published by the Purdue University Press. Copyright 2026.

Permission: Illinois-Indiana Sea Grant


An Integrated Single-Cell And Spatial Transcriptomic Atlas Of Thyroid Cancer Progression Identifies Prognostic Fibroblast Subpopulations, Matthew A Loberg, George J Xu, Sheau-Chiann Chen, Hua-Chang Chen, Claudia C Wahoski, Kailey P Caroland, Megan L Tigue, Heather A Hartmann, Jean-Nicolas Gallant, Courtney J Phifer, Andres A Ocampo, Dayle K Wang, Reilly G Fankhauser, Kirti A Karunakaran, Chia-Chin Wu, Maxime Tarabichi, Sophia M Shaddy, James L Netterville, Sarah L Rohde, Carmen C Solórzano, Lindsay A Bischoff, Naira Baregamian, Barbara A Murphy, Jennifer H Choe, Jennifer R Wang, Eric C Huang, Quanhu Sheng, Luciane T Kagohara, Elizabeth M Jaffee, Ryan H Belcher, Ken S Lau, Fei Ye, Ethan Lee, Vivian L Weiss Jan 2026

An Integrated Single-Cell And Spatial Transcriptomic Atlas Of Thyroid Cancer Progression Identifies Prognostic Fibroblast Subpopulations, Matthew A Loberg, George J Xu, Sheau-Chiann Chen, Hua-Chang Chen, Claudia C Wahoski, Kailey P Caroland, Megan L Tigue, Heather A Hartmann, Jean-Nicolas Gallant, Courtney J Phifer, Andres A Ocampo, Dayle K Wang, Reilly G Fankhauser, Kirti A Karunakaran, Chia-Chin Wu, Maxime Tarabichi, Sophia M Shaddy, James L Netterville, Sarah L Rohde, Carmen C Solórzano, Lindsay A Bischoff, Naira Baregamian, Barbara A Murphy, Jennifer H Choe, Jennifer R Wang, Eric C Huang, Quanhu Sheng, Luciane T Kagohara, Elizabeth M Jaffee, Ryan H Belcher, Ken S Lau, Fei Ye, Ethan Lee, Vivian L Weiss

Faculty, Staff and Student Publications

Although well-differentiated thyroid carcinoma (WDTC) is characterized by a robust treatment response, aggressive subtypes, such as anaplastic thyroid carcinoma (ATC), remain highly lethal. To understand thyroid cancer evolution in both children and adults, we analyzed single-cell transcriptomes of 423,733 cells from 81 samples and spatially resolved key tumor and microenvironment populations across 28 tumors with spatial transcriptomics, including rare and unique composite WDTC/ATC tumors and pediatric diffuse sclerosing thyroid carcinomas. Additionally, we identified gene signatures of stromal cell populations in 5 large thyroid cancer bulk RNA-sequencing cohorts. Through this multi-institutional effort, we defined a population of POSTN+ myofibroblast cancer-associated fibroblasts …


Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams Jan 2026

Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams

Natural Resources Research Articles

Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …


Analysis Of Lake Toba Ecoliteracy In High School Students, Jesika Aurelia Sianipar, B Manurung, Martina Asiati Napitupulu, Abdul Hakim Daulae Jan 2026

Analysis Of Lake Toba Ecoliteracy In High School Students, Jesika Aurelia Sianipar, B Manurung, Martina Asiati Napitupulu, Abdul Hakim Daulae

Jurnal Pendidikan Sains

The Lake Toba ecosystem is currently experiencing increasingly worsening quality degradation, so that instilling environmental awareness through ecoliteracy has become urgent in the world of education. This study aims to measure the ecoliteracy abilities of students at High School 1 Ajibata and High School 2 Balige by reviewing three main aspects: cognitive, affective, and behavioral. Additionally, it will analyze the differences in ecoliteracy levels between the two schools. The type of research used is ex post facto with a quantitative approach. Data were collected through test instruments for the cognitive aspect and questionnaires for the affective and behavioral aspects. The …