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Full-Text Articles in Entire DC Network

Blinking Without Eyelids: First Video-Documented Evidence Of A Blink-Like Reflex In Ophisops Elegans (Reptilia: Lacertidae), Turan Meri̇ç Çelebi̇, Yusuf Çeli̇kaği, Tuana Kinay, Arda Cem Kuyucu, Muammer Kurnaz, Mehmet Kürşat Şahi̇n Jan 2026

Blinking Without Eyelids: First Video-Documented Evidence Of A Blink-Like Reflex In Ophisops Elegans (Reptilia: Lacertidae), Turan Meri̇ç Çelebi̇, Yusuf Çeli̇kaği, Tuana Kinay, Arda Cem Kuyucu, Muammer Kurnaz, Mehmet Kürşat Şahi̇n

Turkish Journal of Zoology

Eyelids play a crucial role in protecting the eyes of vertebrates; however, certain  reptile species, such as Ophisops elegans, completely lack movable eyelids. In this  study, we present the first video-documented evidence of a blink-like reflex in O.  elegans, captured through endoscopic field observations and corroborated by laboratory video analysis. The observed movement consisted of a brief convex  deformation of the ocular surface, lasting approximately 0.3 s and resembling a blink  despite the presence of a fixed transparent brille. This behavior was observed once in  the field and twice under controlled laboratory conditions. We propose that O.  elegans may employ …

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An Antioxidant Cocktail Of Tert-Butylhydroquinone And A Manganese Porphyrin Induces Toxic Levels Of Oxidative Stress In Cancer Cells, Sandra Tamarin, Hannah Jung, Joseph Lamorte, Laura Biesterveld, Gabriel Piñero, Grace Turchetta, Molly Myers, Rebecca Oberley-Deegan, Aimee Eggler Jan 2026

An Antioxidant Cocktail Of Tert-Butylhydroquinone And A Manganese Porphyrin Induces Toxic Levels Of Oxidative Stress In Cancer Cells, Sandra Tamarin, Hannah Jung, Joseph Lamorte, Laura Biesterveld, Gabriel Piñero, Grace Turchetta, Molly Myers, Rebecca Oberley-Deegan, Aimee Eggler

Student Papers, Posters & Projects

Despite significant advancement in cancer treatments, therapies with minimal toxicity to healthy cells are still limited. One targetable weakness of cancer cells is their sensitivity to oxidative stress. We find that the combination of two antioxidants—the common food additive tert-butylhydroquinone (tBHQ) and a manganese porphyrin in clinical trials, MnTnBuOE-2-PyP5+ (MnBuOE)—increases oxidative stress and causes apoptotic death in several cancer cell lines, but not in mouse primary fibroblasts. Investigating the mechanism of cell death, MnBuOE is observed to catalyze the oxidation of tBHQ, producing the electrophilic quinone tert-butylquinone (tBQ). A critical role for tBQ and its electrophilic character was revealed with …

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Sustainability Implications Of Agricultural Practices In The Arkansas Delta: A Field To Market Approach, Melissa Adelle Palumbo Jan 2026

Sustainability Implications Of Agricultural Practices In The Arkansas Delta: A Field To Market Approach, Melissa Adelle Palumbo

Student Theses and Dissertations

The Field-to-Market Fieldprint Calculator is a software tool designed to estimate and compare relative sustainability of differing agricultural practices. This observational research compared conservation techniques to conventional practices in rice and cotton on three separate farms in Northeast Arkansas. Considering management and site conditions, the Fieldprint Calculator was used to compare sustainability metrics to standards at various spatial scales in a spidergraph report. Eight metrics were analyzed to produce reports, including greenhouse gas emissions, water quality and quantity, land and energy use, soil carbon and conservation, and biodiversity. Results showed no significant change in yield between the different production methods, …

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Clinical Workflow Of Spine Stereotactic Radiotherapy And Radiosurgery: Insights From A Single-Institution Physics Perspective, Dennis Mackin, Gizem Cifter, Yana Zlateva, Jihong Wang, Yao Ding, Muhammad Shafiq Ul Hassan, Zhiheng Wang, Parmeswaran Diagaradjane, Fada Guan, Travis C Salzillo, Shane Krafft, Jing Li, Martin C Tom, Amol J Ghia, Tina Marie Briere Jan 2026

Clinical Workflow Of Spine Stereotactic Radiotherapy And Radiosurgery: Insights From A Single-Institution Physics Perspective, Dennis Mackin, Gizem Cifter, Yana Zlateva, Jihong Wang, Yao Ding, Muhammad Shafiq Ul Hassan, Zhiheng Wang, Parmeswaran Diagaradjane, Fada Guan, Travis C Salzillo, Shane Krafft, Jing Li, Martin C Tom, Amol J Ghia, Tina Marie Briere

Faculty, Staff and Student Publications

Spine stereotactic radiotherapy and radiosurgery (SSRS) techniques, encompassing both fractionated stereotactic treatments and single-fraction radiosurgery, are widely used for the management of spinal metastases due to their ability to deliver highly conformal radiation while limiting dose to adjacent critical structures. Clinical outcomes following SSRS, including durable local control and acceptable toxicity, have been reported previously in multiple institutional series. In this manuscript, we describe the clinical workflow used to deliver SSRS at a high-volume academic center, with emphasis on the medical physics processes that support routine clinical practice. Key elements of the workflow include patient selection, treatment region-specific immobilization, CT …

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Are Returns From Commercial Farming Heterogeneous? Case Of Wheat Growers In North India, Saroj Verma, Kirtti Ranjan Paltasingh, Phanindra Goyari Jan 2026

Are Returns From Commercial Farming Heterogeneous? Case Of Wheat Growers In North India, Saroj Verma, Kirtti Ranjan Paltasingh, Phanindra Goyari

Journal of Applied Farm Economics

Contract farming (CF), generally a commercial farming system, is widely perceived as a welfare enhancement strategy in rural areas where agriculture is the major source of livelihood. However, those welfare implications have not been adequately explored in Indian agriculture. So, this study examines the returns to CF and the heterogeneity in their returns across various groups of wheat growers in Haryana, a leading agrarian state in India. Using an endogenous switching regression model on cross-sectional data of 754 farm households, the study found that CF adopters would lose 27% of their gross margins and 11% of their crop output if …

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Writing Professional Papers Worksheet With Scavenger Hunt: A Simple Strategy To Strengthen Dietetic Writing, Stacy Bevan Jan 2026

Writing Professional Papers Worksheet With Scavenger Hunt: A Simple Strategy To Strengthen Dietetic Writing, Stacy Bevan

Journal of Dietetic Education

Time between learning scientific writing skills and when dietetic students need to transfer that knowledge to discipline-specific research papers in upper division courses may result in a lack of writing skills. Dietetic educators be unfamiliar with writing strategies to improve student writing. A Writing Professional Papers worksheet was developed to help students define components of professional papers, draft a thesis, and then participate in a scavenger hunt using examples of two types of professional papers to identify target issues and avoid common issues seen in student papers. Students in an upper division Maternal and Child Nutrition course responded to an …

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Transforming Dietetics Curriculum: A Culinary Nutrition Certificate Grounded In Competency-Based Innovation, Jennifer R. Watson, Rachel C. Sinley, Jangwoo Jo Jan 2026

Transforming Dietetics Curriculum: A Culinary Nutrition Certificate Grounded In Competency-Based Innovation, Jennifer R. Watson, Rachel C. Sinley, Jangwoo Jo

Journal of Dietetic Education

Culinary nutrition has become a promising interdisciplinary field that combines culinary arts and nutritional science to enhance health outcomes through practical, food-based education. As the healthcare landscape increasingly emphasizes preventive care, dietitians are well-positioned to lead culinary nutrition initiatives; however, formal training opportunities remain scarce. To address this gap, Metropolitan State University of Denver (MSU Denver) created a new Culinary Nutrition Certificate that combines experiential cooking coursework from the School of Hospitality with core nutrition education from the Department of Nutrition. This paper places the certificate within the broader context of culinary nutrition and dietetics education, emphasizing the importance of …

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The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu Jan 2026

The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu

Faculty, Staff and Student Publications

Fusobacterium nucleatum is a Gram-negative anaerobe associated with periodontitis and colorectal cancer. It secretes putrescine, a polyamine that promotes biofilm formation by oral co-colonizers and enhances the proliferation of cancer cells. However, the physiological importance of putrescine for F. nucleatum itself remains unexplored. Here, we show that putrescine biosynthesis, mediated by the ornithine decarboxylase gene oda, is essential for F. nucleatum viability. Deletion of oda was only possible when a functional copy was provided in trans, and CRISPR interference of oda expression resulted in complete growth defects. The essentiality of oda was conserved across multiple subspecies. Supplementation with …

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Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi Jan 2026

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

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Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi Jan 2026

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

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Advances In The Creation Of A Dna Barcoding Reference Library For Freshwater Fishes Of Western Ecuador With Emphasis On Metabarcoding Applications, Olivia Grace Schweikart Jan 2026

Advances In The Creation Of A Dna Barcoding Reference Library For Freshwater Fishes Of Western Ecuador With Emphasis On Metabarcoding Applications, Olivia Grace Schweikart

Theses and Dissertations from DePaul University

This research provides a DNA reference library for the freshwater fish species of Western Ecuador, emphasizing endemic species of the Guayas River Basin and southwestern, lowland areas. Western Ecuador is currently grappling with severe overexploitation of its endemic freshwater fishes across many drainage basins, compounded by habitat destruction, pollution from commercial and agricultural activities, and the looming threat of climate change, notably in the form of coastal incursion events. Methods for rapid-surveying biodiversity at community levels is urgently needed. This reference library is particularly designed for metabarcoding applications, providing a non-invasive method for surveying aquatic biodiversity in vulnerable areas using …

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Low Intensity Vibration With Zoledronate Reduces Musculoskeletal Weakness And Adiposity In Estrogen Deprived Female Mice, Gabriel M Pagnotti, Trupti Trivedi, Laura E Wright, Sutha K John, Sreemala Murthy, Ryan R Pattyn, Monte S Willis, Yun She, Sukanya Suresh, Aji F Touray, William R Thompson, Clinton T Rubin, Khalid S Mohammad, Theresa A Guise Jan 2026

Low Intensity Vibration With Zoledronate Reduces Musculoskeletal Weakness And Adiposity In Estrogen Deprived Female Mice, Gabriel M Pagnotti, Trupti Trivedi, Laura E Wright, Sutha K John, Sreemala Murthy, Ryan R Pattyn, Monte S Willis, Yun She, Sukanya Suresh, Aji F Touray, William R Thompson, Clinton T Rubin, Khalid S Mohammad, Theresa A Guise

Faculty, Staff and Student Publications

Aromatase inhibitors are widely used in the treatment of hormone-sensitive breast cancer, but their suppression of estrogen production accelerates bone loss, increases fracture risk, and negatively impacts muscle and fat metabolism. Here, we demonstrate that daily low intensity vibration, serving as a non-drug mimetic for exercise, protects musculoskeletal health in skeletally immature, female mice under complete estrogen deprivation. Subsequent improvements in vertebral bone density are paralleled by greater and leaner skeletal muscle mass and function alongside reduced fat accretion and circulating metabolites. In mature, estrogen deprived mice, vibration enhances weekly bisphosphonate treatment, improving bone density, cortical thickness, and mechanical resistance …

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Evaluation Of Occupational Health And Safety Knowledge, Attitudes, And Practices Of Workers At North Refineries Company, Wesam Awad Hassn, Zeena N. Abdulrahman Jan 2026

Evaluation Of Occupational Health And Safety Knowledge, Attitudes, And Practices Of Workers At North Refineries Company, Wesam Awad Hassn, Zeena N. Abdulrahman

AUIQ Complementary Biological System

Safety is crucial in the oil and gas refinery industry for production and distribution. Companies must ensure a workplace free from common injuries and protected against serious incidents. This paper evaluates employees’ knowledge, attitudes, practices, and workplace environment at North Refineries Company (Baiji). A descriptive cross-sectional study was conducted from September 10, 2024, to September 20, 2025, involving 480 employees (378 workers and 102 managers). Data were collected through face-to-face interviews and analysed using SPSS version 24. North Refineries Company (Baiji). workers scored 72.49 % on general knowledge and 96.83% on attitudes, but only 53.97% on safe behaviour. Division managers …

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Prevention Of Postoperative Nausea And Vomiting In Early Recovery: A Comparative Study Of Ondansetron And Metoclopramide In Adults Undergoing Elective Lower Abdominal Surgery, Majid Fakhir Al-Hamaidah, Ali Ihsan Abdul Mahdi, Maytham Alaa Shahid, Sajjad Salih Rasan, Lina M. Shaker, Shahab Abdulla, Ralela Makline Jan 2026

Prevention Of Postoperative Nausea And Vomiting In Early Recovery: A Comparative Study Of Ondansetron And Metoclopramide In Adults Undergoing Elective Lower Abdominal Surgery, Majid Fakhir Al-Hamaidah, Ali Ihsan Abdul Mahdi, Maytham Alaa Shahid, Sajjad Salih Rasan, Lina M. Shaker, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

Postoperative nausea and vomiting (PONV) remain common complications following surgery, despite the availability of various prophylactic antiemetic agents. This study aimed to compare the effectiveness of ondansetron and metoclopramide in preventing PONV in patients undergoing elective lower abdominal surgery under general anesthesia. In this double-blind, randomized controlled trial, 80 adult patients were equally allocated into two groups: one receiving 0.1 mg/kg of intravenous ondansetron and the other 0.2 mg/kg of intravenous metoclopramide at the end of surgery. The incidence, frequency, and need for rescue antiemetics were evaluated over 24 hours postoperatively. The overall incidence of nausea was higher in the …

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Biology Department Publications: 2025, Sam Lindgren Jan 2026

Biology Department Publications: 2025, Sam Lindgren

Biology Department Bibliographies

This document is a non-comprehensive list of publications made by graduate students, post-doctoral researchers, and faculty members in the Biology Department in 2024. It indexes those publications available through PubMed, and serves as an archival record of the Department's robust scholarly contributions.

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Innovative Applications And Development Paths Of Digital Earth Technology In Marine Environmental Support, Junyi Liu, Xiongfei Liu, Zongji Wang, Zhihong Zeng, Huiping Xie, Siye Liu Jan 2026

Innovative Applications And Development Paths Of Digital Earth Technology In Marine Environmental Support, Junyi Liu, Xiongfei Liu, Zongji Wang, Zhihong Zeng, Huiping Xie, Siye Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The convergence of Digital Earth technologies and the field of marine environmental support represent a significant trend in global scientific and technological advancement. In response to the characteristics of marine environmental data such as sparsity, dynamic complexity, and multi-scale interdependence, and by integrating the evolution of international Digital Earth technology with China’s independent innovation practices, this study constructs three core methodological paradigms. The first is the element-integrated ontology, which proposes a hybrid representation paradigm of “spatiotemporal embedded field + ontology” to achieve integrated and dynamically evolving modeling of marine physical environments alongside geological, biological, chemical, and other multidimensional elements. The …

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Frontiers In Ocean Non-Equilibrium Dynamics And Challenges In Operational Oceanography Application, Yuhong Zhang, Yan Du, Tianyu Wang, Minyang Wang, Qin Duan, Xinlong Li, Yuhang Zheng, Yifan Xia, Shilin Tang, Yineng Li, Jianping Yin Jan 2026

Frontiers In Ocean Non-Equilibrium Dynamics And Challenges In Operational Oceanography Application, Yuhong Zhang, Yan Du, Tianyu Wang, Minyang Wang, Qin Duan, Xinlong Li, Yuhang Zheng, Yifan Xia, Shilin Tang, Yineng Li, Jianping Yin

Bulletin of Chinese Academy of Sciences (Chinese Version)

Ocean circulation exhibits complex multiscale dynamics, among which non-equilibrium processes, marked by transient behavior, strong perturbations, and pronounced nonlinearity, are of particular importance for maritime environmental support. However, limited observational capability has long constrained the study of subsurface non-equilibrium dynamics, leaving numerical models insufficiently validated and positioning this issue at the forefront of modern physical oceanography. Artificial intelligence (AI) offers a promising pathway to overcome this bottleneck. Built on this concept, the “iEddy” AI large ocean model can efficiently reconstruct high-resolution, high-accuracy three-dimensional temperature, salinity, and velocity from sea-surface remote sensing data, demonstrating strong capability in capturing non-equilibrium ocean currents …

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Transparent West-Pacific: Frontier Advances In Earth System Science, Lixin Wu, Jiwei Tian, Weidong Sun, Hailong Liu, Tianyu Chen, Zhimian Cao, Zhao Jing Jan 2026

Transparent West-Pacific: Frontier Advances In Earth System Science, Lixin Wu, Jiwei Tian, Weidong Sun, Hailong Liu, Tianyu Chen, Zhimian Cao, Zhao Jing

Bulletin of Chinese Academy of Sciences (Chinese Version)

The West-Pacific hosts a well-developed trench-arc-basin system characterized by intense fluid–solid interactions, making it an ideal region for studying multi-sphere interactions within the Earth system. Research on cross-sphere dynamic processes and material-energy cycles in the West-Pacific not only represents a core frontier in Earth System Science, but also crucial to addressing major strategic needs, such as global climate change response, sustainable use of marine resources, and protection of the deep-sea environment. This article highlights key advances achieved under the Major Program on West-Pacific Earth System Multispheric Interactions (WESPMI), in areas including multi-scale oceanic interactions, cross-sphere material exchange, plate subduction and …

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Satellite-Derived Bathymetry In Island Coastal Zones: Technology, Shilin Tang, Yuye Huang, Yongming Liu, Jianping Yin, Deke Chen, Ronggang Huang, Shuang Li Jan 2026

Satellite-Derived Bathymetry In Island Coastal Zones: Technology, Shilin Tang, Yuye Huang, Yongming Liu, Jianping Yin, Deke Chen, Ronggang Huang, Shuang Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Shallow bathymetry data constitute the core foundational information underpinning the ecological, resource, and strategic values of island and coastal zones. Satellite-derived bathymetry has evolved into a key technical means for large-scale acquisition of shallow bathymetry information. Focusing on satellite-based lidar bathymetry, optical imaging bathymetry, and synthetic aperture radar (SAR) bathymetry, this study systematically summarizes the core principles, applicable scenarios, technical strengths, and inherent limitations of each technology. It is shown that satellite-derived bathymetry has undergone an evolutionary shift from theoretical construction to practical application, and from single-method, single-data-source approaches to multi-technology, multi-source data fusion frameworks. In the future, to meet …

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Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval Jan 2026

Simulated Complex Cells Contribute To Object Recognition Through Representational Untangling, Mitchell B Slapik, Harel Z Shouval

Faculty, Staff and Student Publications

The visual system performs a remarkable feat: it takes complex retinal activation patterns and decodes them for object recognition. This operation, termed "representational untangling," organizes neural representations by clustering similar objects together while separating different categories of objects. While representational untangling is usually associated with higher-order visual areas like the inferior temporal cortex, it remains unclear how the early visual system contributes to this process-whether through highly selective neurons or high-dimensional population codes. This article investigates how a computational model of early vision contributes to representational untangling. Using a computational visual hierarchy and two different data sets consisting of numerals …

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Radionuclide-Stimulated Dynamic Therapy Induces Complementary Immunogenic Necroptosis And Apoptosis Cancer Cell Death Pathways, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, Lemoyne Habimana-Griffin, Gail Sudlow, Julie Prior, Ezugo Onejeme, Alex Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Luke Stallings, Chidube Alagbaoso, Nathan Reed, Matthew M Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine Weilbaecher, Samuel Achilefu Jan 2026

Radionuclide-Stimulated Dynamic Therapy Induces Complementary Immunogenic Necroptosis And Apoptosis Cancer Cell Death Pathways, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, Lemoyne Habimana-Griffin, Gail Sudlow, Julie Prior, Ezugo Onejeme, Alex Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Cody Hongsermeier, Nisha Gamadia, Nicole Blasi, Luke Stallings, Chidube Alagbaoso, Nathan Reed, Matthew M Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine Weilbaecher, Samuel Achilefu

Faculty, Staff and Student Publications

Radionuclide-stimulated dynamic therapy (RaST) utilizes Cerenkov-radiating radiopharmaceuticals to activate light-sensitive drugs and materials, generating reactive oxygen species (ROS) that inhibit cancer progression. However, the underlying cell death mechanisms are not fully understood. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex and radiolabeled 2-fluorodeoxyglucose, we found that RaST induced apoptosis and necroptosis, characterized by the activation of RIPK-1, RIPK-3, nuclear factor kappa B, and mixed lineage kinase domain-like pseudokinase, leading to membrane permeabilization, cytokine release, and the expression of immunogenic damage-associated molecular patterns. In immune-deficient breast tumor-bearing mice with adequate stroma and growth factors, RaST did not prevent tumor growth …

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Comprehensive Metabolic Profiling Across Five Lifespan Stages In Murine Hippocampus And Cortex Reveals Sex-Related Variation In Age-Related Cognitive Decline, Xi Long, Wuping Liu, Changhan Chen, Qi Guo, Yidan Wang, Fang Yu, Yujin Zhang, Rodney E Kellems, Yang Xia Jan 2026

Comprehensive Metabolic Profiling Across Five Lifespan Stages In Murine Hippocampus And Cortex Reveals Sex-Related Variation In Age-Related Cognitive Decline, Xi Long, Wuping Liu, Changhan Chen, Qi Guo, Yidan Wang, Fang Yu, Yujin Zhang, Rodney E Kellems, Yang Xia

Faculty, Staff and Student Publications

This study employs Barnes maze behavioral assessments, untargeted liquid chromatography-mass spectrometry metabolomics, and 13C6-glucose isotopic tracing to systematically investigate cognitive function and metabolic profiles in hippocampal and cortical tissues of male and female mice across five distinct age-ranges. Behavioral analyses reveal significant cognitive decline in both sexes by 16-months-of-age, with females exhibiting more severe impairment by 23-months, demonstrating a sex-related variation. 13C6-glucose tracing analyses reveals that glucose is rapidly and preferentially metabolized toward the Tricarboxylic acid cycle over glycolysis and the pentose phosphate pathway (PPP), with metabolism rates increasing from juvenility to meet developmental demands and maintaining homeostasis into pre-elderly. …

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Modulation Of Hypothalamic–Limbic Circuits Regulating Appetite In Response To Health Lifestyle In Obese Adults, Nour Shakir Rezaieg, Muthanna M. Awad Jan 2026

Modulation Of Hypothalamic–Limbic Circuits Regulating Appetite In Response To Health Lifestyle In Obese Adults, Nour Shakir Rezaieg, Muthanna M. Awad

Karbala International Journal of Modern Science

Background: Overeating leads to obesity a low-grade inflammatory disease. In this context, aguati-related neuropeptide (AgRP) and ghrelin are pivotal players in appetite regulation, while chemerin is an adipose tissue-secreted adipokine that contributes to low-grade inflammation associated with obesity. Objective: This study used a healthy lifestyle program designed for each obese participant to identify diet-related neuro-hormonal changes in appetite regulation. Design, Setting, and Participants: This a longitudinal quasi-experimental controlled study was conducted from 1st December 2024, to 30th July 2025, at University of Anbar. The sample included 100 participants, 50 obese (weight between 100–140 kg) and 50 healthy participants …

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Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen Jan 2026

Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen

Faculty Publications

Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influences this process. Deletion of host Il1α resulted in rejection of transplanted tumors. Single-cell RNA sequencing identified CX3CR1⁺ macrophages as the main source of IL-1α in the TME. Il1α deficiency disrupted monocyte–macrophage differentiation, reducing CX3CR1⁺ macrophages and increasing iNOS⁺ macrophages. Myeloid cells from Il1α⁻/⁻ hosts induced lower PD-1 and CTLA-4 expression in co-cultured CD8⁺ T cells than those from wild-type hosts. CellChat analysis showed …

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Glutamatergic Projection Neurons In The Basal Forebrain Underlie Learned Olfactory Associational Valence Assignments, Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Qingchun Tong, Benjamin R Arenkiel Jan 2026

Glutamatergic Projection Neurons In The Basal Forebrain Underlie Learned Olfactory Associational Valence Assignments, Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Qingchun Tong, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Sensory perception is shaped by experience, giving stimuli behavioral significance. Basal forebrain (BF) cholinergic neurons in mice, which are crucial for arousal and motivation, also regulate sensory processing. Within BF nuclei, glutamatergic (vGlut2BF) neurons receive cholinergic input and modulate behaviors, but their roles in encoding sensory significance remain unclear. Using in vivo calcium imaging, we found that vGlut2BF neurons initially poorly encoded odor identity. However, their response to conditioned odors increased following associative learning, and their population activity more distinctly encoded paired stimuli, reflecting emergent value representation. Furthermore, pairing stimulation or inhibition of vGlut2BF neurons with specific odors altered odor …

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Integrative Spatial Multi-Omics Reveal Niche-Specific Inflammatory Signaling And Differentiation Hierarchies In Aml, Enes Dasdemir, Ivo Veletic, Christopher P Ly, Andres E Quesada, Christopher D Pacheco, Fatima Z Jelloul, Pamella Borges, Sreyashi Basu, Sonali Jindal, Zhiqiang Wang, Alexander Lazar, Khalida M Wani, Dinler A Antunes, Patrick K Reville, Preethi H Gunaratne, Robert J Tower, Padmanee Sharma, Hussein A Abbas Jan 2026

Integrative Spatial Multi-Omics Reveal Niche-Specific Inflammatory Signaling And Differentiation Hierarchies In Aml, Enes Dasdemir, Ivo Veletic, Christopher P Ly, Andres E Quesada, Christopher D Pacheco, Fatima Z Jelloul, Pamella Borges, Sreyashi Basu, Sonali Jindal, Zhiqiang Wang, Alexander Lazar, Khalida M Wani, Dinler A Antunes, Patrick K Reville, Preethi H Gunaratne, Robert J Tower, Padmanee Sharma, Hussein A Abbas

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a clonal disorder characterized by immature blasts and arrested differentiation that primarily affects the bone marrow (BM) and occasionally presents as extramedullary (EM) disease. EM manifestations highlight AML's adaptability to distinct microenvironments, which we examined using spatial analyses of medullary and EM tissues. We describe a workflow for Visium-based spatial transcriptomics in medullary and EM AML, revealing insights into cell-cell communication and the spatial organization of AML hierarchies. In BM, monocytes and granulocyte-monocyte progenitors colocalized with leukemic populations, sharing molecular signatures with those in EM sample. CXCL12-CXCR4-mediated communication correlated with PI3K/AKT/mTOR signaling in inflammatory niches.

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Probiotics Regulate Gut Microbiota And Immune Homeostasis To Prevent And Treat Food Allergy : A Review, Yao Chen, Zumeng Xia, Yijin Yang, Lianzhong Ai, Guangqiang Wang, Yan Zhang, Zhen Luo, Yong Zhou, Yongjun Xia Jan 2026

Probiotics Regulate Gut Microbiota And Immune Homeostasis To Prevent And Treat Food Allergy : A Review, Yao Chen, Zumeng Xia, Yijin Yang, Lianzhong Ai, Guangqiang Wang, Yan Zhang, Zhen Luo, Yong Zhou, Yongjun Xia

Journal of Food Science and Biotechnology

Food allergy (FA) is a common immunological disorder,and its pathogenesis is primarily associated with a complex regulatory process involving CD 4+ T cells in the immune system,such as the polarization of Th 2 cells and the imbalance between Treg/Th 17 cells.The balance of intestinal immune cells plays a critical role in the development of FA,while dysbiosis of the gut microbiota may disrupt this balance,thereby contributing to the onset of FA.Probiotic intervention targeting the gut microbiota can directly or indirectly influence the functions of immune cells to regulate immune responses,representing a promising approach for the prevention and treatment of FA.The authors …

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Differences In Important Chemical Components And Free Radical Scavenging Activities Of The Ginger Germplasm Resources From Fujian, Meichun Chen, Enquan Lin, Xuefang Zheng, Zuliang Li, Bo Liu, Jieping Wang Jan 2026

Differences In Important Chemical Components And Free Radical Scavenging Activities Of The Ginger Germplasm Resources From Fujian, Meichun Chen, Enquan Lin, Xuefang Zheng, Zuliang Li, Bo Liu, Jieping Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to analyze the important chemical components of different ginger germplasm resources from Fujian and evaluate their comprehensive quality and free radical scavenging activities.[Method ] Gas chromatography-mass spectrometry (GC-MS ) and liquid chromatography-quadrupole-time of flight-mass spectrometry (LC-QTOF-MS ) were employed to determine the importance chemical components in 13 ginger germplasm resources.Differences in the chemical compounds were analyzed by the cluster analysis and principal component analysis (PCA ).The free radical scavenging activities of the ginger germplasm resources against ABTS+ were further evaluated.[Result ] A total of 65 chemical compounds were identified from the 13 ginger germplasm resources,including …

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Antioxidant And Anti-Fatigue Properties Of Malus Spectabilis Fruit Polysaccharides In Mice, Zhilin Wen, Ming Li Jan 2026

Antioxidant And Anti-Fatigue Properties Of Malus Spectabilis Fruit Polysaccharides In Mice, Zhilin Wen, Ming Li

Journal of Food Science and Biotechnology

[Objective ] This study aimed to explore the antioxidant and anti-fatigue properties of Malus spectabilis fruit polysaccharides (MPPs ) and analyze the structure-activity relationships.[Method ] Two types of MPPs were prepared via acidic (AC-MPC ) and alkaline (AL-MPC ) extraction methods.The polysaccharide composition was identified by high-performance anion-exchange chromatography (HPAEC ).The changes in mouse body mass,serum biochemical indicators,and exhaustive swimming time were measured to assess the in vivo antioxidant and anti-fatigue effects of MPPs.[Result ] Galacturonic acid was the main component in both types of MMPs,while AL-MPC had higher mass fraction of total polysaccharides.The in vivo experiments demonstrated that both …

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Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao Jan 2026

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

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