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Developing Algorithms For Quantifying The Super Resolution Microscopic Data: Applications To The Quantification Of Protein-Reorganization In Bacteria Responding To Treatment By Silver Ions, Sai Divya Challapalli

Graduate Theses and Dissertations

Histone-like nucleoid structuring proteins (HNS) play significant roles in shaping the chromosomal DNA, regulation of transcriptional networks in microbes, as well as bacterial responses to environmental changes such as temperature fluctuations. In this work, the intracellular organization of HNS proteins in E. coli bacteria was investigated utilizing super-resolution fluorescence microscopy, which surpasses conventional microscopy by 10–20 fold in spatial resolution. More importantly, the changes of the spatial distribution of HNS proteins in E. coli, by addition of silver ions into the growth medium were explored. To quantify the spatial distribution of HNS in bacteria and its changes, an automatic method …

Holarctic Insects Adventive In Michigan: New And Additional Records (Homoptera, Heteroptera, Coleoptera, Neuroptera), A. G. Wheeler Jr.

The Great Lakes Entomologist

Fourteen European insects in the Homoptera (4 species), Heteroptera (5), Coleoptera (4), and Neuroptera (1) are reported from Michigan. Ten are new state records (one new Ohio record is given). The point of entry for most of the species is assumed to be the northeastern United States or Maritime Provinces of Canada. Possibilities of dispersal (natural and human-assisted) from centers of introduction in the Northeast, multiple introductions from Europe, and direct entry into the Great Lakes region are discussed.

The Evidence Of Non N-Glycan Linked Mannose In Exochitinase (42 Kda) From Trichoderma Harzianum Bio10671 Glycosylation, Mustafa Muskhazli, Zaman Faridah Qamaruz, Ramli Salfarina, Tohfah Nor Farizan, Ithnin Nalisha, Wallis Greg

ASEAN Journal on Science and Technology for Development

Chitinase 42 kDa produced by Trichoderma harzianum has been proven as a prime compound to be excreted onto the hyphae of the pathogen causing localised cell wall lysis at the point of interaction. This finally initiate the process of the host cell becomes empty of cytoplasm, disintegrates and shows a rapid collapse. This study investigates the existence of N-glycan linked mannose in chitinase 42 kDa produced by the Malaysian T. harzianum strain BIO10671. The chitinase 42 kDa from T. harzianum BIO10671 was initially purified using anion exchange chromatography prior to a series of experiments such as immunoblotting against the chitinase …

Geographic Distribution Of Siphonaptera Collected From Small Mammals On Lake Michigan Islands, William C. Scharf

The Great Lakes Entomologist

The distribution of ten flea species collected from five small mammal host species on 13 Lake Michigan islands is described. Four new eastern and southern records for Hystrichopsylla dippiei Rothschild are given. Speculative suggestions are made regarding dispersal routes of some of the small mammal host species, and the distribution of flea species from Peromyscus maniculatus gracilis LeConte is dis- cussed in the context of island biogeography theory.

Additional Observations On Tachypompilus Ferrugineus With Emphasis On Male Behavior (Hymenoptera: Pompilidae), Frank E. Kurczewski

The Great Lakes Entomologist

An aggregation of 11 males and 5 females of Tachypompilus ferrugineus was studied during August and September 1989 at a 2 m-high cemetery monument i Syracuse, NY. Male perching behavior and male-male and male-female interactions are described. Male-male interactions included acceptance, perching in close proximity, wing fanning, circling, following, and flight chases. Overt territoriality was not demonstrated by individual males, although several wasps each maintained a few or several stations. Despite noticeable size variation among wasps, there was no dominant-subordinate hierarchy. Male attachment to the cemetery monument waned as the season progressed due to mortality, increased floral feeding, and decreased …

The Insects Of Treeholes Of Northern Indiana With Special Reference To Megaselia Scalaris (Diptera: Phoridae) And Spilomyia Longicornis (Diptera: Syrphidae), Robert S. Copeland

The Great Lakes Entomologist

The aquatic insect community of treeholes in northern Indiana was surveyed from 1983-1986. Twenty-three species, representing three orders and nine families, were found. Megaselia scalaris (Diptera: Phoridae) was collected on several occasions from rotholes, the first member of this family from treeholes. Examination of puparia of Spilomyia longicornis (Diptera: Syrphidae) indicated that the larva of this species has been previously described, but incorrectly associated with the genus Xylata.

The Synthesis Of A Novel Bibenzopyran Relied On Electrooxydation Of Malloapelta B By Cyclic Voltammetry, Binh Phan Thi, Ninh Bui Hai, Minh Chau Van, Nam Nguyen Hoai, Huong Le Mai, Kiem Phan Van

ASEAN Journal on Science and Technology for Development

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of malloapelta B (Hep-2, IC50: 0.49 µg/ml and KB, IC50: 0.54 µg/ml).

Life History Of Mesovelia Mulsanti (Hemiptera: Mesoveliidae) In Southern Illinois, J. E. Mcpherson

The Great Lakes Entomologist

The life history of Mesovelia mulsanti was studied during 1983-1986. This species was apparently trivoltine with a partial 4th generation at the end of the year. It overwintered as eggs. First ins tars appeared in mid-April followed by marked overlapping of the subsequent instars and generations. The first adults appeared in early May. No active individuals were found after November.

Study Of Y-Chromosome Str Markers In United Arab Emirates Population, Tareq Zeyad Mohammed Ahmed

Theses

The recently introduced 6-dye Yfiler Plus multiplex which includes 27 Y-STR loci (DYS576, DYS389I, DYS635, DYS389II, DYS627, DYS460, DYS458, DYS19, YGATAH4, DYS448, DYS391, DYS456, DYS390, DYS438, DYS392, DYS518, DYS570, DYS437, DYS385 a/b, DYS449, DYS393, DYS439, DYS481, DYF387S1a/b and DYS533) has been used to study 343 UAE Arab male individuals using Yfiler Plus® amplification kit. This set includes seven rapidly mutating loci (RM Y-STRs). These RM Y-STRs are useful for discriminating between closely related and unrelated males.. According to measures of genetic diversity the highest diversity were observed at loci DYS385=(0.94984), DYF387S1=(0.930523) and DYS449=(0.895402). Therefore, these loci should be considered the …

Interaction Of Cocoa Powder With Intestinal Microbiota, Martha M. Escoto Sabillon

LSU Master's Theses

Cocoa is the fully fermented and dried seed of the cacao tree (Theobroma cacao L.) which has prebiotic properties, due to their high concentration of polyphenols. Therefore, the ingestion of cocoa could cause changes in the proportions of the intestinal microbiota that can influence the intestinal immune response. The objective of this study was to determine the effect of alkalization process of the cocoa bean in the diversity of the gut microbiota. The samples were “lavado” unprocessed cocoa powder, “natural” unprocessed cocoa powder, “D-11-S” as alkalized cocoa powder, “D-11-B” heavily alkalized cocoa powder, and raw cocoa “shells” and a control …

Gene Coexpression Network Analysis Of Fruit Transcriptomes Uncovers A Possible Mechanistically Distinct Class Of Sugar/Acid Ratio-Associated Genes In Sweet Orange, Liang Qiao, Minghao Cao, Jian Zheng, Yihong Zhao, Zhi-Liang Zheng

Publications and Research

Background: The ratio of sugars to organic acids, two of the major metabolites in fleshy fruits, has been considered the most important contributor to fruit sweetness. Although accumulation of sugars and acids have been extensively studied, whether plants evolve a mechanism to maintain, sense or respond to the fruit sugar/acid ratio remains a mystery. In a prior study, we used an integrated systems biology tool to identify a group of 39 acid-associated genes from the fruit transcriptomes in four sweet orange varieties (Citrus sinensis L. Osbeck) with varying fruit acidity, Succari (acidless), Bingtang (low acid), and Newhall and Xinhui (normal …

Seasonal Emergence Patterns Of Black Flies (Diptera: Simuliidae) In Northwestern Pennsylvania, P. H. Adler, B. L. Travis, K. C. Kim, E. C. Masteller

The Great Lakes Entomologist

A two-year emergence trap study of black flies at four sites in northwestern Pennsylvania yielded 1%3 individuals of nine species. The collections included Prosimulium mixtum, P. jU5cum, Stegapterna mutata, Simulium aureum, S. excisum (recorded for the first time from Pennsylvania), S. gauldingi, S. sp. nr. innacens, S. vittatum, and S. tuberasum. Species richness for all sites peaked during May. Emergence collections below a sewage plant effluent outfall represented fewer individuals and species than collections above the effluent outfall. Chromosomal analysis of supplementary larval collections revealed the IIIL-l and IS-7 sibling species of S. vittatum and the FG sibling of S. …

Resource Partitioning By Two Species Of Stream Mayflies (Ephemeroptera: Heptageniidae), William O. Lamp, N. Wilson Britt

The Great Lakes Entomologist

We compared the phenology of nymph development, food type, and habitat selection of two stream mayflies, Stenacron interpunctatum (Say) and Stenonema pulchellum (Walsh) in Big Darby Creek, Ohio. Both species, which grow principally from autumn through early spring, emerged from the stream throughout the summer. The nymphs consumed the same sizes and types of food particles from deposits on stones, mostly in the form of detritus. As a result of morphological and behavioral adaptations, S. pulchellum lived on stones in swift water whereas S. interpunctatum lived on stones in a slower current.

Fourlined Plant Bug (Hemiptera: Miridae), A Reappraisal: Life History, Host Plants, And Plant Response To Feeding, A. G. Wheeler Jr, Gary L. Miller

The Great Lakes Entomologist

Phenology of the fourlined plant bug, Poecilocapsus lineatus, is presented for southcen- tral Pennsylvania; life history and habits are re-examined. Although breeding was previously thought to occur only on woody plants, we found that nymphs develop on numerous herbs. An extensive list of hosts, more than 250 species in 57 families, is compiled from the literature and the authors' observations; preferences are noted for plants in the Labiatae, Solanaceae, and Compositae. Damage consists of lesions on foliage, the size and shape of the spots varying with leaf texture, pubescence, and venation. Plant response to feeding is immediately visible, the lesions …

Annotated List Of Indiana Scolytidae (Coleoptera), Mark Deyrup

The Great Lakes Entomologist

A list of 80 species of Indiana Scolytidae (bark and ambrosia beetles) is presented. Notes on known Indiana hosts and distribution in the state are included for each species.

Diverse Amide Analogs Of Sulindac For Cancer Treatment And Prevention, Bini Mathew, Judith V. Hobrath, Michele C. Connelly, R. Kiplin Guy, Robert C. Reynolds

Pharmaceutical Sciences Faculty Publications

Sulindac is a non-steroidal anti-inflammatory drug (NSAID) that has shown significant anticancer activity. Sulindac sulfide amide (1) possessing greatly reduced COX-related inhibition relative to sulindac displayed in vivoantitumor activity that was comparable to sulindac in a human colon tumorxenograft model. Inspired by these observations, a panel of diverse sulindac amide derivatives have been synthesized and their activity probed against three cancer cell lines (prostate, colon and breast). A neutral analog, compound 79 was identified with comparable potency relative to lead 1 and activity against a panel of lymphoblastic leukemia cell lines. Several new series also show good …

Observations Of The Habits Of Lygaeus Kalmii Angustomarginatus (Hemiptera: Lygaeidae) In Southern Michigan, Linda-Margaret Hunt

The Great Lakes Entomologist

Lygaeus kalmii Stal (Hemiptera: Lygaeidae) is an insect found throughout the eastern United States and Canada. There is extensive taxonomic literature on this insect (Stil, 1874; Townsend, 1887; Parshey, 1919, 1923; Slater and Knopf, 1969), but very little attention has been given to the rest of its biology. This study describes the habits of kalmii populations in southern Michigan.

Larval Ecology Of Some Lower Michigan Black Flies (Diptera: Simuliidae) With Keys To The Immature Stages, Richard W. Merritt, Douglas H. Ross, B. V. Peterson

The Great Lakes Entomologist

The species composition, succession, and seasonal abundance of -immature simuliids ocmrrhg in the Rose Lake Wildlife Research Area in lower Michigan are presented. Selected physical and chemical characteristics of streams in the above area were examined and compared in relation to faunal distributions. Comparisons of species differences between permanent and temporary streams were made utilizing the functional group concept based on feeding mechanisms.

Keys and illustrations are presented for the identiiication of larvae and pupae of four genera (Prosimulium, Simulium, Stegopterna, Cnephia) and 19 species of Simuliidae known to occur in lower Michigan. Two species, Cnephia ornithophilia and Simulium vemum, …

Baetis (Ephemeroptera: Baetidae) Of Wisconsin, Edward A. Bergman, William L. Hilsenhoff

The Great Lakes Entomologist

Data on life histories and environmental requirements for species in many mayfly genera remains sketchy at best This is certainly true of Baetis, which is one of the most common components of Wisconsin's lotic fauna. Most Wisconsin streams that are not grossly pobted contain one or more species of the minnow-like nymphs, which are usually found clinging to surfaces of rocks or aquatic plants. Biological studies of Baetis in North America have been neglected primarily because of their enigmatic taxonomy. Even keys of Needham et al. (1935) and Burks (1953), which are considered standard referenas, are either incomplete or difficult …

Male Behavior In Evagetes Subangulatus (Hymenoptera: Pompilidae), Edward M. Barrows

The Great Lakes Entomologist

Males of Evagetes subangulatus patrolled primarily among shrubs in an area where females dug in soil. Twenty-nine individually-marked males were seen from 0 to 16 days after marking. They shared a home range space of about 400 m3. Although they did not exhibit territoriality, they chased and pounced upon one another and upon unmarked, conspecific males and females.

Volume 5, Chapter 2-2: Medical Uses: Biologically Active Substances, Janice M. Glime

Bryophyte Ecology Subchapters

No abstract provided.

Keys And Notes On The Buprestidae (Coleoptera) Of Michigan, Stanley G. Wellso, Gary V. Manley, John A. Jackman

The Great Lakes Entomologist

The distribution and dates of adult activity for Michigan buprestids are discussed. Keys to the genera and species, as well as host information are presented for 116 species and one subspecies. Information on collecting techniques, illustrations of genitalia of 14 species, and scanning electron micrographs of certain structures useful in species identification are presented and discussed. In addition, Pachyschelus confusus, a new species, is described from bush clover.

Spatial And Seasonal Distribution Of Pine Root Collar Weevil Eggs In Young Red Pine Plantations, Louis F. Wilson

The Great Lakes Entomologist

The pine root collar weevil (Hylobius radicis Buchanan) is a continuous threat to young pine plantations in the northeastern United States and the adjacent Canadian Provinces The female weevil oviposits during the daytime (Wilson, 1968a) near the root collars of red pine (Pinus resinosa Aiton), Scotch pine (P. sylvestris L.), and jack pine (P. hanksiana Lambert), and occasionally other pines. During recent studies on the weevil (Wilson 1968a, 1968b) in Michigan, egg data were taken for use in population and sampling research. Presented here are distribution patterns of eggs within and between trees and throughout the …

Study On Thermophysical Properties Of Tobacco And Smoke Agent Under Different Temperature, Ma Yaping, Liu Chaoxian, Wang Le, Zhang Mingjian, Zhang Ke, Deng Nan, Lu Duanfeng, Tang Jianguo, Liu Xiangzhen

Food and Machinery

The thermophysical properties of tobacco and smoke agent (the mass ratio of glycerol and propylene glycol is 51) was measured by transient plane heat source method, and the effects of moisture and smoke agent content on reconstituted cut tobacco and flue-cured were measured. The results showed that with the increase of temperature (22～75 ℃), thermal conductivity \[0.06～0.12 W/(m·K) and 0.06～0.16 W/(m·K\] and volume heat capacity \[0.17～2.70 MJ/(m³K) and 0.15～1.45 MJ/(m³K)\] increased; however, the thermal diffusivity decreased (0.33～0.05 mm² / s and 0.40～0.09 mm² / s, respectively). With the increase of moisture content (0%～13%) , …

The Importance Of Saperda Inornata And Oberea Schaumii (Coleoptera: Cerambycidae) Galleries As Infection Courts Of Hypoxylon Pruinatum In Trembling Aspen, Populus Tremuloides, John C. Nord, Fred B. Knight

The Great Lakes Entomologist

(excerpt) Trembling aspen, Populus tremuloides Michaux, and bigtooth aspen, P. grandidentata Michaux, are hosts of numerous species of injurious insects and microorganisms (Harrison 1959). Only a few of those organisms, however, are directly responsible for mortality of healthy trees. The fungus Hypoxylon pruinatum (Klotzsche) Cke. is most important in that respect, killing 1-2%o f the standing volume annually in the Lake States (Anderson 1964). It invades and spreads in cambial tissue, killing it and eventually the branch or stem by girdling. Initially, a canker appears as a sunken, yellowish-orange area in the bark (Anderson 1956). In a later stage the …

Rare Coding Variants In Plcg2, Abi3, And Trem2 Implicate Microglial-Mediated Innate Immunity In Alzheimer's Disease., Rebecca Sims, Sven J Van Der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis, Eden R Martin, Benjamin Grenier-Boley, Stefanie Heilmann-Heimbach, Vincent Chouraki, Amanda B Kuzma, Kristel Sleegers, Maria Vronskaya, Agustin Ruiz, Robert R Graham, Robert Olaso, Per Hoffmann, Megan L Grove, Badri N Vardarajan, Mikko Hiltunen, Markus M Nöthen, Charles C White, Kara L Hamilton-Nelson, Jacques Epelbaum, Wolfgang Maier, Seung-Hoan Choi, Gary W Beecham, Cécile Dulary, Stefan Herms, Albert V Smith, Cory C Funk, Céline Derbois, Andreas J Forstner, Shahzad Ahmad, Hongdong Li, Delphine Bacq, Denise Harold, Claudia L Satizabal, Otto Valladares, Alessio Squassina, Rhodri Thomas, Jennifer A Brody, Liming Qu, Pascual Sánchez-Juan, Taniesha Morgan, Frank J Wolters, Yi Zhao, Florentino Sanchez Garcia, Nicola Denning, Myriam Fornage, John Malamon, Maria Candida Deniz Naranjo, Elisa Majounie, Thomas H Mosley, Beth Dombroski, David Wallon, Michelle K Lupton, Josée Dupuis, Patrice Whitehead, Laura Fratiglioni, Christopher Medway, Xueqiu Jian, Shubhabrata Mukherjee, Lina Keller, Kristelle Brown, Honghuang Lin, Laura B Cantwell, Francesco Panza, Bernadette Mcguinness, Sonia Moreno-Grau, Jeremy D Burgess, Vincenzo Solfrizzi, Petra Proitsi, Hieab H Adams, Mariet Allen, Davide Seripa, Pau Pastor, L Adrienne Cupples, Nathan D Price, Didier Hannequin, Ana Frank-García, Daniel Levy, Paramita Chakrabarty, Paolo Caffarra, Ina Giegling, Alexa S Beiser, Vilmantas Giedraitis, Harald Hampel, Melissa E Garcia, Xue Wang, Lars Lannfelt, Patrizia Mecocci, Gudny Eiriksdottir, Paul K Crane, Florence Pasquier, Virginia Boccardi, Isabel Henández, Robert C Barber, Martin Scherer, Lluis Tarraga, Perrie M Adams, Markus Leber, Yuning Chen, Marilyn S Albert, Steffi Riedel-Heller, Valur Emilsson, Duane Beekly, Anne Braae, Reinhold Schmidt, Deborah Blacker, Carlo Masullo, Helena Schmidt, Rachelle S Doody, Gianfranco Spalletta, W T Longstreth, Thomas J Fairchild, Paola Bossù, Oscar L Lopez, Matthew P Frosch, Eleonora Sacchinelli, Bernardino Ghetti, Qiong Yang, Ryan M Huebinger, Frank Jessen, Shuo Li, M Ilyas Kamboh, John Morris, Oscar Sotolongo-Grau, Mindy J Katz, Chris Corcoran, Melanie Dunstan, Amy Braddel, Charlene Thomas, Alun Meggy, Rachel Marshall, Amy Gerrish, Jade Chapman, Miquel Aguilar, Sarah Taylor, Matt Hill, Mònica Díez Fairén, Angela Hodges, Bruno Vellas, Hilkka Soininen, Iwona Kloszewska, Makrina Daniilidou, James Uphill, Yogen Patel, Joseph T Hughes, Jenny Lord, James Turton, Annette M Hartmann, Roberta Cecchetti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Carlo Caltagirone, Maria Donata Orfei, Antonio Ciaramella, Sabrina Pichler, Manuel Mayhaus, Wei Gu, Alberto Lleó, Juan Fortea, Rafael Blesa, Imelda S Barber, Keeley Brookes, Chiara Cupidi, Raffaele Giovanni Maletta, David Carrell, Sandro Sorbi, Susanne Moebus, Maria Urbano, Alberto Pilotto, Johannes Kornhuber, Paolo Bosco, Stephen Todd, David Craig, Janet Johnston, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Nick C Fox, John Hardy, Roger L Albin, Liana G Apostolova, Steven E Arnold, Sanjay Asthana, Craig S Atwood, Clinton T Baldwin, Lisa L Barnes, Sandra Barral, Thomas G Beach, James T Becker, Eileen H Bigio, Thomas D Bird, Bradley F Boeve, James D Bowen, Adam Boxer, James R Burke, Jeffrey M Burns, Joseph D Buxbaum, Nigel J Cairns, Chuanhai Cao, Chris S Carlson, Cynthia M Carlsson, Regina M Carney, Minerva M Carrasquillo, Steven L Carroll, Carolina Ceballos Diaz, Helena C Chui, David G Clark, David H Cribbs, Elizabeth A Crocco, Charles Decarli, Malcolm Dick, Ranjan Duara, Denis A Evans, Kelley M Faber, Kenneth B Fallon, David W Fardo, Martin R Farlow, Steven Ferris, Tatiana M Foroud, Douglas R Galasko, Marla Gearing, Daniel H Geschwind, John R Gilbert, Neill R Graff-Radford, Robert C Green, John H Growdon, Ronald L Hamilton, Lindy E Harrell, Lawrence S Honig, Matthew J Huentelman, Christine M Hulette, Bradley T Hyman, Gail P Jarvik, Erin Abner, Lee-Way Jin, Gyungah Jun, Anna Karydas, Jeffrey A Kaye, Ronald Kim, Neil W Kowall, Joel H Kramer, Frank M Laferla, James J Lah, James B Leverenz, Allan I Levey, Ge Li, Andrew P Lieberman, Kathryn L Lunetta, Constantine G Lyketsos, Daniel C Marson, Frank Martiniuk, Deborah C Mash, Eliezer Masliah, Wayne C Mccormick, Susan M Mccurry, Andrew N Mcdavid, Ann C Mckee, Marsel Mesulam, Bruce L Miller, Carol A Miller, Joshua W Miller, John C Morris, Jill R Murrell, Amanda J Myers, Sid O'Bryant, John M Olichney, Vernon S Pankratz, Joseph E Parisi, Henry L Paulson, William Perry, Elaine Peskind, Aimee Pierce, Wayne W Poon, Huntington Potter, Joseph F Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Christiane Reitz, John M Ringman, Erik D Roberson, Ekaterina Rogaeva, Howard J Rosen, Roger N Rosenberg, Mark A Sager, Andrew J Saykin, Julie A Schneider, Lon S Schneider, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Rudolph E Tanzi, Tricia A Thornton-Wells, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Fabienne Garzia, Feroze Golamaully, Gislain Septier, Sebastien Engelborghs, Rik Vandenberghe, Peter P De Deyn, Carmen Muñoz Fernadez, Yoland Aladro Benito, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Lena Kilander, Rosemarie Brundin, Letizia Concari, Seppo Helisalmi, Anne Maria Koivisto, Annakaisa Haapasalo, Vincent Dermecourt, Nathalie Fievet, Olivier Hanon, Carole Dufouil, Alexis Brice, Karen Ritchie, Bruno Dubois, Jayanadra J Himali, C Dirk Keene, Joann Tschanz, Annette L Fitzpatrick, Walter A Kukull, Maria Norton, Thor Aspelund, Eric B Larson, Ron Munger, Jerome I Rotter, Richard B Lipton, María J Bullido, Albert Hofman, Thomas J Montine, Eliecer Coto, Eric Boerwinkle, Ronald C Petersen, Victoria Alvarez, Fernando Rivadeneira, Eric M Reiman, Maura Gallo, Christopher J O'Donnell, Joan S Reisch, Amalia Cecilia Bruni, Donald R Royall, Martin Dichgans, Mary Sano, Daniela Galimberti, Peter St George-Hyslop, Elio Scarpini, Debby W Tsuang, Michelangelo Mancuso, Ubaldo Bonuccelli, Ashley R Winslow, Antonio Daniele, Chuang-Kuo Wu, Oliver Peters, Benedetta Nacmias, Matthias Riemenschneider, Reinhard Heun, Carol Brayne, David C Rubinsztein, Jose Bras, Rita Guerreiro, Ammar Al-Chalabi, Christopher E Shaw, John Collinge, David Mann, Magda Tsolaki, Jordi Clarimón, Rebecca Sussams, Simon Lovestone, Michael C O'Donovan, Michael J Owen, Timothy W Behrens, Simon Mead, Alison M Goate, Andre G Uitterlinden, Clive Holmes, Carlos Cruchaga, Martin Ingelsson, David A Bennett, John Powell, Todd E Golde, Caroline Graff, Philip L De Jager, Kevin Morgan, Nilufer Ertekin-Taner, Onofre Combarros, Bruce M Psaty, Peter Passmore, Steven G Younkin, Claudine Berr, Vilmundur Gudnason, Dan Rujescu, Dennis W Dickson, Jean-François Dartigues, Anita L Destefano, Sara Ortega-Cubero, Hakon Hakonarson, Dominique Campion, Merce Boada, John Keoni Kauwe, Lindsay A Farrer, Christine Van Broeckhoven, M Arfan Ikram, Lesley Jones, Jonathan L Haines, Christophe Tzourio, Lenore J Launer, Valentina Escott-Price, Richard Mayeux, Jean-François Deleuze, Najaf Amin, Peter A Holmans, Margaret A Pericak-Vance, Philippe Amouyel, Cornelia M Van Duijn, Alfredo Ramirez, Li-San Wang, Jean-Charles Lambert, Sudha Seshadri, Julie Williams, Gerard D Schellenberg

Articles, Abstracts, and Reports

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10

Cross-Reactive Immunity To Porcine Reproductive And Respiratory Syndrome Virus And Its Contribution To Protection, Ignacio Correas

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Due to the vast geographical distribution and significant economic losses generated, porcine reproductive and respiratory syndrome virus (PRRSV) can be considered the most important swine pathogen of contemporary times. Current control and eradication strategies against PRRSV have difficulty succeeding because of their complex nature and the absence of an effective vaccine. A major obstacle for PRRSV vaccine development is the broad heterogeneity of the virus, both at the genetic and antigenic level, its rapid evolution, and an incomplete knowledge of the immune responses responsible for clearing the virus from the host. Specifically, how known correlates of protection against PRRSV—neutralizing antibodies …

Impact Of Introduced Parasitoid Cotesia Vestalis (Hymenoptera: Braconidae) On Plutella Xylostella (Lepidoptera: Plutellidae) And Its Parasitoid Guild On Kale In Semi-Arid Areas In Kenya, Ruth Kahuthia-Gathu, Brigitte Nyambo, Sevgan Subramanian

All Peer-Reviewed Publications

Cotesia vestalis was introduced into Kenya from South Africa in March 2003 for biological control of Plutella xylostella with initial release in 2004. To confirm establishment, the rate of spread beyond the release sites and parasitism rates by C. vestalis were assessed between October 2011 and April 2012 in eastern and southeastern Kenya (Kitui, Mwingi/Yatta and Loitokitok areas). Monthly observations on kale infestation by diamondback moth, damage scores, parasitism and parasitoid guild were undertaken on 20 randomly selected plants in farmer-managed kale farms. Sampled larval and pupal stages were placed in containers and taken to the laboratory for parasitoid emergence. …

Specificity Determination By Paralogous Winged Helix-Turn-Helix Transcription Factors, Adam Joyce

Arts & Sciences Graduate Student Theses and Dissertations

Transcription factors (TFs) localize to regulatory regions throughout the genome, where they exert physical or enzymatic control over the transcriptional machinery and regulate expression of target genes. Despite the substantial diversity of TFs found across all kingdoms of life, most belong to a relatively small number of structural families characterized by homologous DNA-binding domains (DBDs). In homologous DBDs, highly-conserved DNA-contacting residues define a characteristic ‘recognition potential’, or the limited sequence space containing high-affinity binding sites. Specificity-determining residues (SDRs) alter DNA binding preferences to further delineate this sequence space between homologous TFs, enabling functional divergence through the recognition of distinct genomic …

How Do Former Undergraduate Mentors Evaluate Their Mentoring Experience 3-Years Post-Mentoring: A Phenomenological Study, Kari L. Nelson, Christine E. Cutucache

The Qualitative Report

This phenomenological study involves a unique, longitudinal assessment of the lived experiences of former undergraduate mentors (n=7) in light of their current experiences (i.e., career or advanced schooling). The objective of a phenomenological study is to engage in in-depth probing of a representative number of participants. Specifically, we followed up with graduates of the Nebraska STEM 4U (NE STEM 4U) intervention 3 years post-program, with the overall goal of describing the mentors’ experiences using the lens of their current experiences. This type of longitudinal perspective of mentoring is greatly lacking in the current literature. At the time of the interviews, …