Digital Commons Network^™

Novel Pan-Err Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism And Mitochondrial Function, Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Wilderman, Lei Qi, Andrea Graves, Jernie Rae Dela Cruz Rideb, Yuanbiao Zhao, Matthew Hayes, Keyang Yu, Mckenna Losby, Carissa S Hampton, Christiana M Adeyemi, Seok Jae Hong, Eleni Nasiotis, Chen Fu, Tae Gyu Oh, Weiwei Fan, Michael Downes, Ryan D Welch, Ronald M Evans, Aleksandar Milosavljevic, John K Walker, Brian C Jensen, Liming Pei, Thomas Burris, Lilei Zhang

Faculty, Staff and Students Publications

BACKGROUND: Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a potential therapeutic intervention for HF. However, in vivo studies demonstrating the potential usefulness of ERR agonist for HF treatment are lacking, because compounds with pharmacokinetics appropriate for in vivo use have not been available.

METHODS: Using a structure-based design approach, we designed and synthesized 2 structurally distinct pan-ERR agonists, SLU-PP-332 and SLU-PP-915. We investigated the effect of ERR agonist on cardiac function in a pressure overload-induced HF model in vivo. We …

Central Flyway Review, North American Bird Bander

North American Bird Bander

No abstract provided.

Books, North American Bird Bander

North American Bird Bander

No abstract provided.

Western Regional News, North American Bird Bander

North American Bird Bander

No abstract provided.

Western Regional News, North American Bird Bander

North American Bird Bander

No abstract provided.

Letters, North American Bird Bander

North American Bird Bander

No abstract provided.

Synthetic Oct-A Blood Vessel Maps Using Fundus Images And Generative Adversarial Networks, Ashanul Haque, Mohd Wajid Ali Khan, Khalaf M Alenezi, Raoudha Soury, Muhammad S Khan, Shahzaib Ahamad, Md Mushtaque, Dinesh Gupta

Faculty, Staff and Student Publications

The design and development of new small-molecule glycation inhibitors are essential for preventing various chronic diseases, including diabetes mellitus, immunoinflammation, cardiovascular, and neurodegenerative diseases. 4-Thiazolidinone or thiazolidine-4-one is a well-known heterocyclic compound with the potential to inhibit the formation of advanced glycation end products. In the present work, we report the synthesis and characterization of four new 5-arylidene 3-cyclopropyl-2-(phenylimino)thiazolidin-4-one (1–4) compounds and their human serum albumin glycation inhibitory activity. One of the compounds 5-(2H-1,3-benzodioxol-5-ylmethylidene)-3-cyclopropyl-2-(phenylimino)-1,3-thiazolidin-4-one (3) showed potent inhibition in the synthesis of initial, intermediary, and final products of glycation reactions. Besides, conformational …

Embryonic Development Of The American Kestrel (Falco Sparverius): External Criteria For Staging, J. M. Pisenti, G. M. Santolo, J. T. Yamamoto, A. A. Morzenti

Journal of Raptor Research

No abstract provided.

Notes On The Breeding Biology Of The Long-Legged Buzzard (Buteo Rufinus) In Bulgaria, Iliya Ts. Vatev

Journal of Raptor Research

No abstract provided.

Raptor Nests As A Habitat For Invertebrates: A Review, James R. Philips, Daniel L. Dindal

Journal of Raptor Research

No abstract provided.

Third Meeting Of The Raptor Research Foundation, Byron E. Harrell

Journal of Raptor Research

No abstract provided.

Positive Responses Of Solanum Lycopersicum Growth To Additions Of Gibberellin In The Presence Of Wounding Stress, Tatum Curtin

Undergraduate Scholarship

Herbivory is a consistent and prevalent stressor that threatens plants. Gibberellin, a naturally occurring plant growth hormone, has been known to increase plant growth when under a physical stress such as herbivory. To investigate, we set up a two-factorial design with 60 Solanum lycopersicum plants and subjected 15 plants each to four treatment groups: reference/control, 65 mg gibberellin, wounding, and 65 mg gibberellin+wounding. We found that S. lycopersicum root-to-shoot ratio decreases with the addition of gibberellin under mechanical wounding stress. Additionally, chlorophyll fluorescence increases under any mechanical wounding, with and without gibberellin present. Our experiment allows us to conclude that …

Development Of Microfluidic Thermal Gel Electrophoresis For Biological Analysis, Mario Ambrocio Cornejo

Wayne State University Dissertations

ABSTRACTDEVELOPMENT OF MICROFLUIDIC THERMAL GEL ELECTROPHORESIS FOR BIOLOGICAL ANALYSIS by MARIO AMBROCIO CORNEJO May 2024 Advisor: Dr. Thomas H. Linz Major: Chemistry (Analytical Chemistry) Degree: Doctor of Philosophy The molecular biology that takes place within cells is vital to the over function of an organism. Healthy cellular function is crucial to a wide web of interconnected processes that need to be balanced and regulated. When these processes become abnormal, disease states are developed. The mapping of biological networks has led to the development of gene therapy and more accurate diagnostic tests. However, there are still vital biomolecules that due to …

Evaluating Functional Inhibitors Of Acid Sphingomyelinase As Potential Negative Modulators Of Microvesicle Particle Release In Response To Skin Stressors, Taskin Sabit

Browse all Theses and Dissertations

Many diseases including lupus erythematosus, atopic eczema, and rosacea can be associated with photosensitivity, which is an abnormal response to sunlight. Recent studies by our group have implicated microvesicle particles (MVP) as playing an important role in causing inflammation and systemic immunosuppression. Previous studies show that functional inhibitors of acid sphingomyelinase (FIASMA) can block MVP release in response to ultraviolet B (UVB) radiation or Platelet-activating Factor (PAF) agonist, which are skin stressors. However, more research needs to be conducted to evaluate the role of PAF, UVB and FIASMA in MVP generation and to formulate a therapeutic medication to be potentially …

Design And Synthesis Of Aminoglycoside-Based Heparan Sulfate Mimetics For Structure-Activity Relationship Studies Of Heparan-Binding Proteins, Joseph Wakpal

Wayne State University Dissertations

Cancer remains a formidable challenge in modern medicine, demanding innovative approaches and treatments. Among the emerging strategies, inhibiting heparanase and fibroblast growth factor 2 (FGF2) has garnered considerable attention in recent years. This dissertation presents a novel approach to designing and synthesizing a diverse library of heparan sulfate (HS) mimetics derived from aminoglycosides to study their binding to two heparin-binding proteins involved in cancer development and metastasis. Heparanase cleaves HS polysaccharide chains in the extracellular matrix (ECM) and is a regulator of aggressive tumor behavior. Clinical studies have illustrated that aberrant heparanase expression correlates with increased tumor size, amplified tumor …

The History Of -Eer In English: Suffix Competition Or Symbiosis?, Zachary Dukic, Chris C. Palmer

Graduate Publications – English

Ecological models of competition have provided great explanatory power regarding synonymy in derivational morphology. Competition models of this type have certainly shown their utility, as they have demonstrated, among other things, the relevance of frequency measures, productivity, compositionality and analyzability when comparing the development of morphological constructions. There has been less consideration of alternative models that could be used to describe the historical co-development of suffixes that produce words with sometimes similar forms or meanings but are not inevitably or solely in competition. The symbiotic model proposed in this article may help answer larger questions in linguistics, such as how …

Working Definitions For Equity, Timothy Berry, Henry Morris, Brian Martensen

All Resources

The underpinnings of what it means for higher education to support diversity, equity and inclusion is often problematized by different interpretations of key terms necessary to work systematically. Inspired by efforts in both the office of Diversity, Equity and Inclusion and Academic Affairs, we will use the following working definitions in its efforts to increase awareness, understanding and collective action as we work toward our vision and mission.

Breaking Down Microtubule Formation: Characterizing The Biochemical And Cellular Functions Of The Γ-Tubulin Ring Complex, Adi Y. Berman

Student Theses and Dissertations

The γ-Tubulin ring complex (γ-TuRC) is an essential regulator of the microtubule cytoskeleton. It is composed of>30 individual proteins that include the major component, γ-tubulin, as well as γ-tubulin complex proteins 2-6 (GCP2-6), mitotic-spindle organizing proteins associated with a ring of γ-tubulin proteins 1 and 2 (MOZART, or MZT1 and MZT2), and an actin molecule. This ~2.2MDa assembly regulates microtubule dynamics by facilitating the nucleation of new microtubules, modulating microtubule minus-end dynamics by acting as a minus-end cap, and anchoring microtubules to specify their cellular localization. These three major activities of the γ-TuRC, nucleation, capping, and anchoring, contribute to …

Optimal Control Frameworks For A Class Of Epidemiological And Oncological Models, Asma Ali H Alghamdi

Mathematics Dissertations - Archive

In this thesis, we employ optimal control frameworks in two distinct contexts: Human immunodeficiency virus (HIV) and esophageal cancer. For HIV, we introduce a comprehensive data-driven nonlinear optimization framework designed for personalized therapies. This framework utilizes a deterministic in-host nonlinear ordinary differential equation (ODE) model and formulates two optimization problems using individual patient data. The first problem focuses on estimating patient-specific parameters through constrained optimization, while the second problem determines optimal combination therapies to reduce viral load to undetectable levels. Several numerical experiments suggest that our framework can provide a robust and effective optimal dosages with lower toxicity levels to …

Synthesis And Bioevaluation Of Piperazine-Based Compounds As Anti-Cancer Agents In Pancreatic Cancer, Holly E. Moots

Graduate Thesis and Dissertation 2023-2024

Pancreatic cancer is the sixth leading cause of cancer-related death and new therapies are needed. In this investigation two piperazine-based compound classes were discovered with anticancer activity against human pancreatic cancer cells. The use of piperazine moieties in medicinal chemistry has garnered increased interest because FDA-approved anticancer piperazine derivatives (i.e. Imatinib) have demonstrated significant impact in cancer treatment.

The first half of this study describes the discovery of a class of piperazine-based compounds that function as far upstream binding protein 1 (FUBP1) inhibitors. FUBP1 is a single-stranded DNA/RNA binding protein that functions as a master regulator of various genes, including …

Machine Learning Algorithms To Study Multi-Modal Data For Computational Biology, Khandakar Tanvir Ahmed

Graduate Thesis and Dissertation 2023-2024

Advancements in high-throughput technologies have led to an exponential increase in the generation of multi-modal data in computational biology. These datasets, comprising diverse biological measurements such as genomics, transcriptomics, proteomics, metabolomics, and imaging data, offer a comprehensive view of biological systems at various levels of complexity. However, integrating and analyzing such heterogeneous data present significant challenges due to differences in data modalities, scales, and noise levels. Another challenge for multi-modal analysis is the complex interaction network that the modalities share. Understanding the intricate interplay between different biological modalities is essential for unraveling the underlying mechanisms of complex biological processes, including …

Lessons From An Iconic Grouper: Sex, Science, And Serendipity, Yvonne J. Sadovy De Mitcheson

Gulf and Caribbean Research

From a common little damselfish and spectacular grouper aggregations, to disappearing reef fishes and the dark side of the international seafood trade, my journey has passed through a fascinating and worrying period of change in the way we view and treat our oceans. Although much of my career has been in the Indo—Pacific, I focus here mainly on my professional ‘roots’ in the Caribbean and on the Nassau Grouper Epinephelus striatus, a species that kept me curious, taught me patience, never to assume and always to stay hopeful. This fish is almost an obsession; why can we not better safeguard …

Next-Generation Alpha Irradiation Platform: Design, Development, And Applications In Radiobiological Research, Harsh Arya

Physics Dissertations - Archive

This dissertation unveils the innovative design, development, and application of a next-generation alpha irradiation platform, specifically crafted for pre-clinical and university-level radiobiological research. Driven by the quest to overcome the inherent limitations of existing alpha particle irradiators, this study explores the profound therapeutic potential of alpha particles in cancer treatment. Known for their exceptional high linear energy transfer (LET), alpha particles exhibit a unique prowess in inducing clustered DNA damage, sparking intriguing possibilities for highly targeted cancer therapies. Yet, their application has been historically constrained by their limited range of biological tissues and the absence of precise delivery systems.

Our …

The Cumulative Incidence And Site Of Recurrent Metastatic Breast Cancer And Post-Metastasis Survival Of Females With An Initial Diagnosis Of Non-Metastatic Breast Cancer In New South Wales, Sarah Jane Lord

Theses

This dissertation aimed to investigate the population-level incidence, site, and survival of recurrent metastatic breast cancer (rMBC) occurring after stage I−III breast cancer, and changes over time. Breast cancer mortality has declined over the last 30 years due to advances in screening, diagnosis, and treatment. However, the impact of improved cancer care on rMBC is not yet well understood because cancer registries do not routinely report on cancer recurrence (Chapter 1). A systematic review of 20 population-based studies provided evidence of improvements in survival for people with de novo metastatic breast cancer (stage IV at diagnosis) since 1995 in high-income …

Heteroleptic Coumarin-Based Silver(I) Complexes: Possible New Antimicrobial Agents, Erika Mooney, Brendan Twamley, Gordon Cooke, Emma Caraher, Matthias Tacke, Fintan Kelleher, Bernadette S. Creaven

Articles

Heteroleptic coumarin-based silver(I) complexes with improved solubility profiles were synthesised using either triphenylphosphine or an N-heterocyclic carbene as adduct ligands, and were fully characterised using IR and NMR spectroscopy, elemental analysis, and, where possible, X-ray crystallography. The triphenylphosphine adducts formed well-resolved structures, where the oxyacetate ligands asymmetrically chelated the silver(I) ion in a bidentate chelating mode, and the silver(I) ion was also bound to two triphenylphosphine ligands. The solubility profile and photostability of the adducts were considerably improved compared to those of previously isolated simple coumarin silver(I) complexes. Analysis of the coumarin N-heterocyclic carbene(NHC) silver(I) adduct indicated that it likely …

Teaching Difficult Topics: Reflections From The Undergraduate Music Classroom, Olivia R. Lucas, Laura Moore Pruett

Faculty Publications

Teaching Difficult Topics provides a series of on-the-ground reflections from college music instructors working in a wide variety of institutional settings about their approaches to inclusive, supportive pedagogy in the music classroom. Although some imagine the music classroom to be an apolitical space, instructors find themselves increasingly in need of resources for incorporating issues of race and ethnicity, gender and sexuality, and historical trauma into their classrooms in ways that support student learning and safeguard their classroom communities. The teaching reflections in Teaching Difficult Topics examine difficult themes that fall into three primary categories: subjects that instructors sense to be …

Recent Advances In Chemistry And Antioxidant/Anticancer Biology Of Monoterpene And Meroterpenoid Natural Product, Benedict J. Barras, Taotao Ling, Fatima Rivas

Faculty Publications

Monoterpenes and meroterpenes are two large classes of isoprene-based molecules produced by terrestrial plants and unicellular organisms as diverse secondary metabolites. The global rising incidence of cancer has led to a renewed interest in natural products. These monoterpenes and meroterpenes represent a novel source of molecular scaffolds that can serve as medicinal chemistry platforms for the development of potential preclinical leads. Furthermore, some of these natural products are either abundant, or their synthetic strategies are scalable as it will be indicated here, facilitating their derivatization to expand their scope in drug discovery. This review is a collection of representative updates …

Development Of A Ni-Catalyzed Enantioselective Intramolecular Mizoroki- Heck Reaction For The Synthesis Of Phenanthridinone Derivatives, Diana Rachii

Bryn Mawr College Dissertations and Theses

The Birch reduction-alkylation coupled to the desymmetrizing Mizoroki-Heck reaction is a novel synthetic tool to form potentially bioactive phenanthridinone analogs from inexpensive and easily available starting materials. This work describes a rare example of the direct replacement of palladium for nickel in our previously reported enantioselective intramolecular Heck reaction. A Ni-catalyzed enantioselective intramolecular Mizoroki-Heck reaction has been developed to transform symmetrical 1,4- cyclohexadienes with attached aryl halides to phenanthridinone analogs containing quaternary stereocenters. Moreover, this approach provides direct access to six-member ring heterocyclic systems bearing all-carbon quaternary stereocenters, which have been much more challenging to form enantioselectively with nickel-catalyzed Heck …

Development Of Small Ligands Targeting Pathogenic Rna Repeats In Neurodegenerative Diseases, Zhihua Chang

Legacy Theses & Dissertations (2009 - 2024)

Pathogenic microsatellite RNA expansions are toxic and can cause neuronal degeneration and dysfunction. Therapeutics that eliminate or neutralize these RNA repeats hold great promise for the treatment of many neurodegenerative diseases because they are uniformly fatal but there is no effective treatment available today. New compounds targeting these pathogenic RNA repeat sequences represent new hope to treat these diseases. The overall goal of my dissertation is to develop a high-throughput screening assay to identify small ligands as potential drug candidates against disease-associated RNA repeats and probe binding mechanisms to guide the design of optimized drug candidates, and eventually validate therapeutic …

Traditional Chinese Medicine: Employing Integrative Medicine As An Approach To Treat Cancer, Jade Hudson

CMC Senior Theses

This thesis explores the history of Traditional Chinese Medicine (TCM) through its depiction in the four classics of TCM and examines the evolution of the field to date. The five categories of TCM treatments analyzed in this paper include acupuncture, dietary therapy, herbal medicine, moxibustion, and physical exercise. Research highlights significant positive outcomes in cancer patients who incorporate TCM alongside modern cancer treatments, such as reduced nausea, vomiting, fatigue, anorexia, pain, and improvements in quality of life and overall well-being. However, notable risks associated with TCM herbal medicine and moxibustion underscore the need for further research into these practices before …