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Timing Of Migration And Seasonal Movements Of Arctic Grayling (Thymallus Arcticus) In Relation To Water Temperature In The Kakisa River And Upper Mackenzie River, Nwt: Results From An Acoustic Telemetry Study., Levi Snook

Theses and Dissertations (Comprehensive)

Arctic grayling (Thymallus arcticus) are a cold-water salmonid that inhabit waterbodies throughout the circumpolar regions of the northern hemisphere. In the last decade, Ka'a'gee Tu First Nation members as well as local sport fishers, have observed lower catches of Arctic grayling during their annual spawning run in the Kakisa River, NWT. Many potential causes of this decline have been hypothesized including climate change and over harvesting. Outside of the general annual spawning activity in the headwaters of the Kakisa River, the ecology of the population, including post-spawn habitat use and migratory patterns, remained understudied. To address these knowledge gaps, acoustic …

Marine And Freshwater Habitats Used By Sympatric Anadromous Arctic Char (Salvelinus Alpinus) And Dolly Varden (S. Malma Malma) In The Central Canadian Arctic, Simon W. Depasquale Mr.

Theses and Dissertations (Comprehensive)

Two closely related but distinct species of char, Arctic Char (Salvelinus alpinus) and Dolly Varden (S. malma), are critically important to the food security and culture of Indigenous peoples in northern North America. Subsistence Inuit fishers in Kugluktuk, NU, Canada, have noticed changes in the timing and locations of their catches of char in the past ~ 10 years. In response, an ongoing partnered research program between the Kugluktuk Hunters and Trappers Organization (HTO) and scientists was formed to study Arctic Char and northern form Dolly Varden (S. malma malma). Char research near Kugluktuk presents a unique opportunity to further …

Characterizing The Targeting Of Toc159 Receptors To The Chloroplast Outer Envelope Membrane And Their Role In The Assembly Of Distinct Toc Complexes, Michael Fish

Theses and Dissertations (Comprehensive)

Global agriculture and food security face challenges from climate change, population growth, and other human-driven pressures. Enhancing our understanding of plant biology, particularly chloroplast function, is critical for improving crop yield and stress resilience. As the sites of photosynthesis and key regulators of plant responses to environmental cues, chloroplasts depend on the precise import of thousands of nuclear-encoded proteins to maintain their biogenesis and function. While much is known about the core translocon components in the chloroplast outer envelope membrane that form the TOC complex, the mechanisms underlying their targeting, assembly, and regulation remain incompletely understood.

Plastids, including chloroplasts, evolved …

Macroinvertebrate Communities And Food Web Structure In Tundra Streams Are Shaped By Substrate Size And Beaver Impoundments, Mathew K. Mervyn

Theses and Dissertations (Comprehensive)

North American beavers (Castor Canadensis) are expanding their range into the Arctic tundra as climate change drives earlier ice and snowmelt, and increased shrub cover. As ecosystem engineers, beavers build dams that alter water chemistry by creating impoundments within streams, trapping sediment and organic matter, and modifying nutrient cycling. This thesis evaluates how beaver impoundments interact with natural geomorphic variation in tundra streams and how impoundments affect tundra freshwater ecosystems in the western Canadian Arctic.

In Chapter 2, I compared water chemistry and benthic macroinvertebrate (BMI) community composition across 16 stream reaches, including those with and without beaver dams, with …

Fisheries Research Report No. 345: Metropolitan Monitoring Program 2024, Alissa C. Tate, Claire B. Smallwood, Karina L. Ryan

Fisheries Research Reports

Ongoing monitoring of recreational fisheries in the Metropolitan zone is essential to ensure the sustainable use of fisheries resources. Surveys of shore- and boat-based recreational fishers within the Metropolitan zone of the West Coast bioregion provide information on human dimensions and catch-per-fisher as well as mean length and weight of key recreationally caught species. For shore-based fishers, estimates of fishing effort, catch and harvest are also presented for key nearshore species. Information in this report is used to support ongoing assessments for key nearshore species and inform the development and evaluation of harvest strategies and other management actions, such as …

The Theory Of Evolution, Alois Nicholas Wurst

Bachelors’ Theses

What is perhaps one of the most fascinating questions in the scientific and philosophical world today is the theory on the Decent of Man. We hear much concerning Evolution. New theories on the subject appear almost daily. Most of these seem to be hoaxes on the part of publicity hungry scientists. If a man would have his name in newspapers the world over, he must only say that he produced a living organism out of inanimate matter. Of course such a statement produces a sensation. But this sensation is short lived. Investigation usually exposes prevarication on the part of the …

Characterizing Niche Specialization In Staphylococcus Epidermidis, Sandra Jablonsk

Dissertations

This thesis investigates the microbial diversity of Staphylococcus epidermidis (S. epidermidis) across various anatomical sites in the human body. While traditionally viewed as a benign skin microbe, S. epidermidis also inhabits the urinary, gastrointestinal, and respiratory tracts, raising questions about its genetic variation and adaptability in different environments. The research aims to compare strains of S. epidermidis isolated from the oral cavity, nostrils, urinary tract, and skin of healthy individuals to determine if they share a common ancestor or if they evolved independently in response to specific environmental factors. The study comprises three main aims. Aim 1 focuses on assessing …

Computational Analysis And Characterization Of The Inducible 1-Cysteine Peroxiredoxin Promoter In The Malaria Parasite Plasmodium, Lara Ladney

Dissertations

Malaria afflicts over 200 million people annually, which results in over half a million deaths, primarily in sub-Saharan Africa. Malaria parasites are complex protozoan organisms that inhabit two hosts: humans, the site of asexual reproduction, and the Anopheles mosquito, where sexual reproduction occurs. To withstand the hostile extracellular environment of the Anopheles mosquito, the malaria parasite Plasmodium berghei employs antioxidant defense mechanisms. Previous work suggests upregulation of 1-Cysteine Peroxiredoxin (1-CPxn) when the mosquito uptakes a blood meal containing the parasite. The parasite must acclimate to the harsh environmental conditions of the mosquito midgut: find a way to counteract reactive oxygen …

Analyzing The Population Structure Of The Rhizobia Associated With Astragalus Lentiginosus, Joshua Adam Melnick

Dissertations

Legumes are an incredibly diverse and agriculturally important family of plants. They have a special relationship with symbiotic bacteria known as rhizobia which fix nitrogen into ammonia within nodules on their roots. Astragalus is the largest plant genus on Earth, and the species Astragalus lentiginosus is extraordinarily diverse, consisting of approximately 40 varieties. However, the rhizobia of A. lentiginosus have never been studied. In this study, root nodules were extracted from 17 varieties of A. lentiginosus to obtain rhizobial strains and metagenomes. A. lentiginosus primarily associates with rhizobia from the genera Mesorhizobium and Allomesorhizobium. There was little evidence of horizontal …

Toll-Like Receptor Signaling In Neurons Modulates C. Elegans Feeding Behavior In A Hunger State-Dependent Manner, Neel Patel, Joseph Rios, Retwika Ganguly, Cindy Mutafoglu, Nour Shalash, Karla Gallardo, Malak Saleh, John Chahine, Emily Kopecky, Gursimran Gujral, Kamya Shah, Christos Suriano

Department of Biology Faculty Scholarship and Creative Works

Animals face the risk of encountering pathogenic microbes while foraging for resources. Assessing the risk of nutrition vs. infection can result in the behavioral regulation of immune processes. Behavioral immunity in the nematode roundworm Caenorhabditis elegans (C. elegans) is regulated, in part, by the innate immune molecule TOL-1: a homolog of vertebrate Toll-like Receptor (TLR) proteins that influences C. elegans pathogen avoidance behaviors by promoting the development of CO2-detecting chemosensory neurons. While TOL-1′s role in pathogen avoidance is well established, its role in an opposing behavior – foraging – has not been examined. In addition to pathogenic bacteria, preferred food …

Microbial Mavericks: Turning Hazards Into Snacks, Alison G. Blanton

Biology Dissertations - Archive

Symbiotic associations with microbes are widespread across life and provide hosts with essential and beneficial functions. A growing concern in pest management is symbiont-mediated detoxification (SMD), a form of metabolic resistance to insecticides. The best-known example of SMD involves the bean bug Riptortus pedestris, where an environmentally acquired but obligate Caballeronia symbiont confers resistance to the organophosphorus insecticide fenitrothion. Motivated by this model, I began my work in another known bug-Caballeronia symbiosis: Leptoglossus phyllopus, native to the United States. I then expanded the study to include two additional U.S.-native hosts, Leptoglossus zonatus and Anasa tristis. Representative …

Interspecific Interactions And Resource Availability As Drivers Of Species Occurrences, Edita Folfas

Biology Dissertations - Archive

Understanding what forces determine species occurrence is central to studies of community ecology. Species interact with each other and their environment, and these interactions scale up to shape global patterns of diversity. In my first chapter, I examined how predation might shape patterns of Anolis lizard species richness and abundance across landscapes on islands in the Greater Antilles. I quantified predatory bird occurrence by using thousands of observations from an online citizen science database (eBird). I then obtained estimates of anole abundance and diversity by conducting local field surveys and using mark-resight methods. While predators could negatively impact anole abundance …

Bilirubin Hepatic And Intestinal Transport And Catabolism: Physiology, Pathophysiology, And Benefits, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Terry D. Hinds, Jr., Wang-Hsin Lee

Pharmacology and Nutritional Sciences Faculty Publications

Bilirubin, a metabolite derived from heme degradation, has traditionally been regarded as a waste product and a marker of liver injury. However, increasing evidence suggests that bilirubin also functions as a hormone, and reduced levels are associated with metabolic dysfunction. Studies have shown a strong association between low circulating bilirubin levels and an increased risk of metabolic disorders and cardiovascular disease. To advance bilirubin-based treatment strategies, it is essential to elucidate the mechanisms underlying bilirubin transport and metabolism. Therefore, we provide an in-depth discussion of bilirubin production and its subsequent fates, with a particular focus on the transport between the …

Gut Microbiome, Neuroinflammation, And Fetal Alcohol Spectrum Disorders: Insights From Rodent Models, Abdulrahman M. Busayli, Wenhua Xu, Ghaidaa A. Raffah, Gang Chen

Pharmacology and Nutritional Sciences Faculty Publications

Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism is not well understood. Recently, considerable attention has been focused on the influence of gut microbiome on brain development through the gut–brain axis. Changes in the gut microbiome resulting from ethanol exposure may contribute to the pathology of FASD, potentially involving neuroinflammation. This literature review summarizes the existing research and primary animal studies on the impact of early ethanol exposure on the gut microbiome, neuroinflammation, brain development, …

Native Bee Utilization Of Sorghum And Community Richness In Western Kansas Agricultural System, Katelyn M. Strack

Master's Theses or Doctor of Nursing Practice

In recent years, biologists have documented numerous threats facing native bee populations globally. Current agricultural practices have significant and often negative effects on native bee populations. It is imperative that we understand how these practices affect native bees. Sorghum (Sorghum bicolor (L.) Moench) is cultivated heavily in western Kansas as a grain crop. There is some evidence that native bees can utilize sorghum pollen in other systems. This study investigates whether native bees utilize pollen from sorghum and whether the presence of sorghum in the landscape influences the structure of native bee communities. We conducted observations of sorghum …

A Geometric Morphometrics Analysis Of The Limb Morphologies Of Mosasaurs And Its Palaeoecological Implications, Zachary J. Herbert

Master's Theses or Doctor of Nursing Practice

Mosasaurs were a major component of Late Cretaceous marine ecosystems, being the last Mesozoic radiation of secondarily aquatic tetrapods into diverse niches.

To shed light on the diversity and evolution of limb morphology in this clade, geometric morphometrics analyses were performed on seven skeletal elements from the forelimb and hindlimb. This study tested the hypothesis tested that mosasaurs living in similar environments would exhibit similar morphologies.

After analyzing datasets containing 29 taxa, the observed patterns did not support the hypothesis that habitat was the primary variable influencing morphology. The recurrence of a pattern, the plotting of plioplatecarpine mosasaurs closer to …

The Influence Of Anthropogenic Infrastructure On The Reproductive Success Of Northern House Wrens (Troglodytes Aedon) In Proximity To Highways, Nana-Esi Irie Hanson

Master's Theses or Doctor of Nursing Practice

Anthropogenic disturbances, particularly road infrastructure and noise pollution, significantly affect avian populations, influencing their ecology, behaviour, and reproductive success. This study examined the impact of highway proximity on the reproductive success of the Northern House Wrens (Troglodytes aedon) in a rural landscape. Noise levels and reproductive outcomes were compared between two sites in Hays, Kansas: a high-traffic site near Interstate 70 (Sternberg Museum Nature Trail) and a lower-traffic site at Big Creek on the Fort Hays State University campus. I hypothesized that increased traffic volume and noise pollution would negatively affect Northern House Wren reproductive success. Ambient noise …

Man With An Itchy Back, Katherine Schaffer, Nevin Adamski, Brittany Ambrose, Kathleen Anderson

Department of Emergency Medicine Faculty Publications

[First paragraph] A 61-year old man with no significant past medical history presented with painful bug bites on his lower back 1 day after a 1.5-week-long visit to Africa. He noticed bug bites on his lower back 3 days ago; since then, they have increased in size and become more painful. He was prescribed doxycycline at urgent care earlier that morning and had taken 1 dose. He is taking prophylactic medications for malaria and has had no fever at home. Vital signs, exquisitely tender papular lesions with a central punctum and surrounding erythema in the bilateral paralumbar regions.

A 40-Week Phase 2b Randomized, Multicenter, Double-Blind, Placebo-Controlled Study Evaluating The Safety And Efficacy Of Memantine In Amyotrophic Lateral Sclerosis, Salman Bhai, Todd Levine, Dan Moore, Robert Bowser, Andrew J. Heim, Maureen Walsh, Aziz Shibani, Zachary Simmons, James Grogan, Namita A. Goyal, Raghav Govindarajan, Yessar Hussain, Tania Papsdorf, Tiffany Schwasinger-Schmidt, Nick Olney, Kim Goslin, Michael Pulley, Edward J. Kasarskis, Michael Weiss, Susan W. Katz, Suzan Moser, Duaa Jabari, Omar Jawdat, Jeffrey Statland, Mazen M. Dimachkie, Richard Barohn, Neuromuscular Study Group And Western Als Consortium Memantine Als Study Group

Neurology Faculty Publications

Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no known cure, limited treatment options with minimal benefits, and significant unmet need for disease modifying therapies.

Aims: This study investigated memantine's impact on ALS progression, with an additional focus on the effects of memantine on cognitive and behavioral changes associated with the disease.

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted from December 2018 to September 2020. ALS patients were enrolled in-person and remotely across 13 sites in the United States. Participants were randomized to memantine (20 mg twice daily) or placebo in a 2:1 ratio …

Effects Of Dietary Energy Source And Stress On Equine Intestinal Permeability And Inflammation, Amanda R. Bauman

Theses and Dissertations--Animal and Food Sciences

Dietary concentrate is often provided to exercising horses to meet energy requirements. However, both high-starch and high-fat diets may be associated with alterations in intestinal barrier function. To investigate this, 32 mature horses were fed one of four isocaloric dietary concentrate treatments (n = 8 per treatment): 1) a concentrate with cracked corn providing 4 g starch⋅kg BW^-1⋅d^-1 and 0.2 g fat⋅kg BW^-1⋅d^-1 (CC), 2) a concentrate with puffed corn providing 4 g starch⋅kg BW^-1⋅d^-1 and 0.2 g fat⋅kg BW^-1⋅d^-1 (PC), 3) a concentrate with puffed corn and …

Metabolic And Barrier Function In Response To Β-Caryophyllene In Intestinal Epithelial Cells, Hannah Scroggins

Theses and Dissertations--Animal and Food Sciences

Butyrate, a short-chain fatty acid, regulates cellular metabolism and energy status in intestinal epithelial cells. β-caryophyllene (BCP) is a plant-derived compound that may provide advantageous effects on intestinal barrier function and nutrient utilization. The goal of this thesis was to investigate the effects of BCP on butyrate utilization and metabolism in intestinal epithelial cells. Throughout this thesis, Caco-2 cells in hanging inserts in multi-well plates were used as a model for the intestinal barrier. One study was conducted to investigate the effect of BCP on butyrate utilization and barrier function in intestinal epithelial cells. A second study aimed to elucidate …

Comparison Of Sheep And Cattle Rumen Microbiological And Physiological Responses To An Abrupt Transition From A High-Forage To A High-Concentrate Diet, Katherine Purvis

Theses and Dissertations--Animal and Food Sciences

Sheep and cattle are often used interchangeably due to having the same gastrointestinal anatomy; however literature directly comparing the two species is minimal. Previous in vitro studies have pointed towards potential species differences in rumen carbohydrate utilization and acidosis susceptibility. The objective of this study was to evaluate in vivo microbiological and physiological responses of wethers and steers when abruptly transitioned from a high-forage to a high-concentrate diet. We hypothesized there are differences between species in response to abrupt dietary transition with respect to intake, rumen microbiology, and the rumen environment. Individually housed, rumen cannulated purebred Polypay wethers (n = …

New Observations Of Common Snook, Centropomus Undecimalis, In Mississippi Coastal Waters, With A Summary Of Local Records, Tiffany A. Weidner, William C. Tilley, Brooke Doucet, Angelos Apeitos, Eric A. Saillant, James S. Franks, Jeremy M. Higgs

Gulf and Caribbean Research

No abstract provided.

Early Season Tropical Cyclones Affect Birds Breeding On A Barrier Island, Theodore J. Zenzal Jr., Amanda N. Anderson, Brock Geary, Jessica Schulz, Robert C. Dobbs, Wylie C. Barrow Jr., James H. Waddle

Gulf and Caribbean Research

Animal populations often experience acute natural disturbances, most of which are connected to short—term weather events. Occurrences of early—season tropical cyclones during the peak of the avian breeding season are likely to increase with climate change, which can substantially impact populations of coastal breeding birds at multiple scales. To understand the acute impacts of severe tropical cyclones, we investigated how abundances of breeding birds changed before and after 4 early season named tropical cyclones on a barrier island in the Gulf of Mexico. We detected a change in pre— versus post—storm numbers of breeding birds after 2 out of 4 …

Presence Of Potential Nursery Habitat For The Lemon Shark In Mississippi Coastal Waters, Lindsay K. Bomgardner, P. O. Grammer, Angie Hoover, Anna Millender, Jeremy Higgs, Jill M. Hendon, Michael J. Andres

Gulf and Caribbean Research

No abstract provided.

Ina Scuba: Mobilization Of French West Indies Scuba Diving Clubs To Rapidly Improve Knowledge On Threatened Marine Species. Case Of The White-Spotted Eagle Ray (Aetobatus Narinari)., Océane Beaufort, Rocio Prieto González

Gulf and Caribbean Research

The White—Spotted Eagle Ray (Aetobatus narinari), listed as Endangered on the IUCN Red List since 2021, is experiencing alarming population declines, underscoring the urgent need for targeted conservation efforts. This species, which plays a vital ecological role in marine food webs, has biological and ecological characteristics that make it particularly vulnerable to habitat degradation and anthropogenic pressures, particularly fishing, tourism, and maritime traffic. In the French West Indies (FWI), the paucity of data on the White—Spotted Eagle Ray remains a major obstacle to the development of effective, island—specific conservation strategies. To address this gap, the INA Scuba participatory …

Phytochemical And Nutritional Composition Of Vernonia Amygdalina: Antioxidant, Antidiabetic Efficacy, And Hematological Benefits, Hassan A. Adewuyi, Messiah Atapia, Emmanuel Ochonung, Sakariyau A. Waheed, Adebimpe H. Oluwatoyin, Chizoba V. Obunadike, Adeleye A. Edema, Samad Hussein, Usman A. Mohammed, Kevin L. Sebastine, Tolulope O. Jaiyeola

Chemistry & Biochemistry Faculty Publications

Vernonia amygdalina, a traditionally used medicinal plant, has been purported to possess health-promoting properties. The aim of this study is to investigate the phytochemical and nutritional composition of V. amygdalina, evaluate its antioxidant and antidiabetic efficacy, and assess its hematological benefits. Phytochemical screening, proximate analysis, antioxidant assays (DPPH, ABTS), antidiabetic evaluations in treptozotocin induced diabetic rats, and hematological assessments were conducted according to standard protocol. V. amygdalina exhibited a rich phytochemical profile, comprising flavonoids, phenolic acids, and terpenoids, alongside significant antioxidant activity (IC50 = 12.5 μg/mL) and complete source of protein. Proximate analysis revealed high protein (21.1%) and …

Evaluating The Chemical Reactivity Of Wildfire-Derived Dissolved Organic Molecules: Glutathione Binding Through Kendrick Mass Defect Analysis, Hannah M. Hamontree, Patrick G. Hatcher

Chemistry & Biochemistry Faculty Publications

The emerging risks to organisms of pyrogenic-derived dissolved organic matter (PyDOM) from forest fires are of concern due to its toxic and mutagenic potential (e.g., pro-oxidative responses in fauna through the depletion of glutathione, a nitrogen- and sulfur-containing tripeptide found in cells). This study simulates this phenomenon in a laboratory setting by identifying bonding between reduced l-glutathione and organic molecules in leachates from environmentally weathered biomass samples (charred and uncharred) using Kendrick Mass Defect (KMD) analysis from formula lists obtained from negative-mode electrospray ionization-Fourier transform-ion cyclotron resonance-mass spectrometry ((-)ESI-FT-ICR-MS). These formula lists reveal a 10-fold increase in nitrogen- and sulfur-containing …

Clostridioides Difficile Infection Study Models And Prospectives For Probing The Microbe-Host Interface, Tatiana Zvonareva, David S. Courson, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

Clostridioides difficile infection (CDI) is an urgent public health threat with a high rate of recurrence and limited treatment options. In vivo models have been indispensable in understanding CDI pathophysiology and establishing treatment protocols and continue to be essential in pre-clinal testing. More importantly, in vivo models offer the opportunity to probe the complex systemic host response to the microbe, which is impossible to recapitulate in vitro. Nonetheless, constraints related to the availability of animal models, cost, ethical considerations, and regulatory control limit their accessibility for basic research. Furthermore, physiological and habitual divergences between animal models and humans often result …

Lap-Hsp60 Complex Modulates Epithelial Tight Junction Barrier, Arun Bhunia, Manalee Manalee Samaddar, Chen Sun, Nicholas Gallina, Nicole Irizarry-Tardi, Donqi Liu, Shivendra Tenguria, Rishi Drolia, Anika Jain, Daisuke Kihara, Wen Jiang, Kee-Hong Kim, Abigail Cox, Kurt Ristroph, Gregory Knipp, Nicholas Noinaj

Biological Sciences Faculty Publications

During infection, Listeria adhesion protein (LAP), a housekeeping enzyme, acts as a tight junction modulator (TJM) through interaction with Hsp60 to facilitate Listeria monocytogenes translocation across the intestinal epithelial barrier. Here, we used purified LAP as a potential TJM to overcome the limiting and variable effects observed by other agents in the class. We structurally determined the LAP interaction alone and in complex with Hsp60 utilizing cryo-EM and computational analysis. LAP structure resolved at 2.83 Å, forms multimeric interlocking dimers and tetramers, and the N-domain interacts with Hsp60, while the C-domain bridges the bacterial surface receptor InlB. The structural studies …