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Articles 6391 - 6420 of 113545
Full-Text Articles in Entire DC Network
German Cockroach Allergen Mitigation, Olivia Katz
German Cockroach Allergen Mitigation, Olivia Katz
Theses and Dissertations--Entomology
German cockroaches (Blatella germanica L.) remain one of the most challenging indoor pests to manage, due in large part to their cryptic nature, rapid reproduction, and resistance to insecticides. Because of their close proximity to humans, they also pose several serious health threats, including the production and dissemination of several potent allergens linked to asthma development and exacerbation. Given the risks associated with cockroach allergens, we examined the longevity of two distinct cockroach allergens (Bla g 1 and Bla g 5) in the home environment and the efficacy of cleaners at removing these allergens. Our findings show that Bla …
Unveiling The Bacterial Communities Of Aphaenogaster: Taxonomic Composition, Developmental And Species Influences, And The Impact Of Climate Change, Lily Kelleher
West Chester University Master’s Theses
Ants are vital keystone species in many ecosystems because they provide ecosystem services such as: seed dispersal, soil bioturbation, and pest control. However, ant bacterial symbioses remain largely unstudied, but these interactions are crucial because microbes play a vital role in the ants’ overall health. Today, global climate change is impacting our biodiversity, and we can use information about how changing temperatures impact the symbiotic bacterial communities associated with ants to predict future impact. Aphaenogaster rudis and A. fulva remain understudied in terms of their bacterial community and are important North American species. For this study, ants from several colonies …
Wild Horse Overpopulation- Consequences And Environmental Effects, Tessa M. Eslick Ms.
Wild Horse Overpopulation- Consequences And Environmental Effects, Tessa M. Eslick Ms.
Undergraduate Theses, Professional Papers, and Capstone Artifacts
When considering wild horse overpopulation, there are many different facets of the issue that need to be addressed. Wild horse overpopulation is a significant issue across the American West, particularly on lands managed by the Bureau of Land Management( BLM). The largest populations are often found in Nevada, other states include California, Oregon, Utah, Wyoming, Washington, and Arizona. Whether there are thousands of horses on many acres of land, or hundreds spread across smaller reservations or public lands, the effects of their overpopulation remain as imminent as ever. Overpopulation is causing ecological damage and strain on resources leading to concerns …
The Power Of Plate & Knowledge: Nutrition’S Role In Pcos Management For Asian American Women, Cassandra Curameng Diego Curameng
The Power Of Plate & Knowledge: Nutrition’S Role In Pcos Management For Asian American Women, Cassandra Curameng Diego Curameng
Nursing | Senior Theses
Polycystic ovarian syndrome (PCOS) is a common metabolic endocrine condition with symptoms that severely impair women's physical and reproductive health. However, individuals with PCOS, especially Asian American women, lack sufficient understanding of non-pharmacological symptom management options, such as dietary and lifestyle modifications. This research proposal explores whether culturally appropriate nutrition education can help manage PCOS symptoms and lessen the need for medical management. The literature critique focuses on addressing the knowledge gap regarding treatment management among women diagnosed with PCOS, health risks related to PCOS, ethnic differences, and nutrition. This proposal investigates the impact of a dietary education program tailored …
A Vascular Flora Of Ladd Canyon, Santa Ana Mountains, Orange And Riverside Counties, California, Daniel P. Donovan, Amanda E. Fisher
A Vascular Flora Of Ladd Canyon, Santa Ana Mountains, Orange And Riverside Counties, California, Daniel P. Donovan, Amanda E. Fisher
Aliso: A Journal of Systematic and Floristic Botany
The Santa Ana Mountains are a coastal range on the border of Orange and Riverside counties in southern California. Ladd Canyon, covering 18.2 km2 in the Cleveland National Forest, is a botanical black hole relative to the rest of the Santa Ana Mountains because of limited access. It is dominated by chaparral and coastal sage scrub and includes significant knobcone pine (Pinus attenuata) stands and riparian woodland. Features that make it an intriguing area to study include the only serpentine soil in the Santa Ana Mountains, large tracts of habitat that have no recorded fire history, steep …
Swosu Research And Scholarly Activity Fair 2025, Swosu Office Of Sponsored Programs
Swosu Research And Scholarly Activity Fair 2025, Swosu Office Of Sponsored Programs
SWOSU Research and Scholarly Activity Fair Programs
On behalf of the members of the University Research and Scholarly Activity Committee (USRAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University (SWOSU) — welcome to the Thirty-Third SWOSU Research and Scholarly Activity Fair!
This year’s event features 99 poster presentations and 9 oral presentations, showcasing the work of over 170 student and faculty researchers, writers, presenters, artists, collaborators, and faculty sponsors. These presentations represent a wide array of scholarly and academic activity from across SWOSU’s academic community, including the Departments of Art, Communication, and Theatre; Allied Health Sciences; Biological Sciences; Business; Chemistry & …
Alzheimer’S Disease And The Immune System: The Emerging Role Of Temra Cells, Edric D. Winford, Adam D. Bachstetter
Alzheimer’S Disease And The Immune System: The Emerging Role Of Temra Cells, Edric D. Winford, Adam D. Bachstetter
Neuroscience Faculty Publications
No abstract provided.
Exploring The Reproductive Phenology Of Feral Horses In North America, Mattie Budine
Exploring The Reproductive Phenology Of Feral Horses In North America, Mattie Budine
Undergraduate Theses, Professional Papers, and Capstone Artifacts
Feral horses (Equus ferus caballus) are a prolific species in western North America. Due to their life history traits and history of domestication, they have a longer foaling period compared to native ungulates, such as elk (Cervus canadensis) and mule deer (Odocoileus hemionus). I examined the observed foaling seasons of different regional herds throughout North America to identify if foaling seasons are uniform across latitudes or if they present a latitudinal shift similar to ungulates. My dataset (n=523 foals) consisted of various research studies and unpublished observations of different feral horse herds throughout North America. The results are graphs comparing …
Bridging Prairie Restoration And Regenerative Agriculture With Compost Tea / The Rocket Incident: Post-Fire Soil Microbe Recovery On The Eastern Washington University Restoration Site, April Hersey
EWU Masters Thesis Collection
Inland Pacific Northwest prairie is an endangered ecosystem that has been reduced by conversion to agriculture. There is growing interest in the role of soil microorganisms in prairie ecosystems, which may be crucial for restoration of the plant community through interspecies interactions within the rhizosphere. One method for improving soil microorganism community composition is compost tea: enriched liquid compost extract. Compost tea is used in regenerative agriculture to improve crop yields and protect against pathogens. While research has supported compost tea application in regenerative agriculture, it has not been widely studied in the context of ecosystem restoration. After beginning a …
A Hybrid Image Filtering Approach For Improving Edge Detection Of Riverbed Particles With Complex Textures, Po-Wei Lin, Hsun-Chuan Chan
A Hybrid Image Filtering Approach For Improving Edge Detection Of Riverbed Particles With Complex Textures, Po-Wei Lin, Hsun-Chuan Chan
Journal of Marine Science and Technology–Taiwan
The distribution of particle size in gravel-bed rivers affects the flow condition, sediment transport, and river morphology. However, conventional particle size analysis is laborious and time-consuming. To enhance the efficiency of particle size analysis, image-based methods have been widely explored, but complex particle textures increase the difficulty in identifying particle edges during image analysis. This study develops a filtering approach based on the rolling guidance filter and leverages the differences in grayscale gradients between particle edges and textures to design a guidance image tailored for the rolling guidance filter. This design enables the filter to preserve particle edges while smoothing …
The Effect Of Bait Types On Catch Performance In The Vietnamese Swimming Crab Trap Fishery, Nghiep K. Vu, Khanh Q. Nguyen, Luong T. Nguyen
The Effect Of Bait Types On Catch Performance In The Vietnamese Swimming Crab Trap Fishery, Nghiep K. Vu, Khanh Q. Nguyen, Luong T. Nguyen
Journal of Marine Science and Technology–Taiwan
Trapping is a primary fishing method to capture swimming crab species along the coast of Vietnam, because it has low ecological and environmental impacts. In trap fisheries, bait plays a primary role in determining the effectiveness of the gear and is one of the largest operational costs. Fishermen determine bait types based on their experience and what they can find, where trash fish caught by trawl fisheries is preferred and commonly used. However, the catch rates of swimming crab traps are typically low and highly variable and thus, there is considerable interest to improve the catchability. This study examined the …
Research On Ship Track Prediction Based On Ipso-Cnn, Xiangen Bai, Nuo Chen, Xiaofeng Xu
Research On Ship Track Prediction Based On Ipso-Cnn, Xiangen Bai, Nuo Chen, Xiaofeng Xu
Journal of Marine Science and Technology–Taiwan
With the rapid development of the global economy, international imports and exports have become increasingly important. Timely and effective tracking and prediction of ship trajectories are important in the face of complex maritime traffic. Based on AIS data, this study establishes a ship trajectory prediction model combining improved particle swarm optimization (IPSO) and a convolutional neural network (CNN) that uses the ship's historical navigation trajectory data to predict the future navigation trajectory. The historical ship trajectory data of the Port of Ningbo-Zhoushan were selected for the experiment, and the IPSO-CNN model experiment results were compared with those of other models. …
Effect Of Creatine Monohydrate On Spatialworking Memory, Body Weight, And Food Intake In Male And Female Rats, Cyrilla H. Wideman, Alexandria Iemma, Olivia Janolo, Anastasiya Kalinina, Helen M. Murphy
Effect Of Creatine Monohydrate On Spatialworking Memory, Body Weight, And Food Intake In Male And Female Rats, Cyrilla H. Wideman, Alexandria Iemma, Olivia Janolo, Anastasiya Kalinina, Helen M. Murphy
2025 Faculty Bibliography
Background/Objectives: Creatine monohydrate supplementation has gained popularity in the fitness industry due to its ability to enhance athletic performance and has sparked curiosity about other possible effects of the supplement. The purpose of this study was to examine the effect of creatine supplementation on spatial working memory, body weight, and food intake in male and female rats.
Methods: Experimental rats, six male and six female, were administered creatine while six male and six female rats served as controls. The Morris water maze (MWM) was employed to assess spatial working memory. Body weight and food intake were measured daily.
Results: Neither …
Spatial Variation In Sexual Size Dimorphism And Mating Associations In The Color Polymorphic Eastern Red-Backed Salamander (Plethodon Cinereus), Maggie M. Hantak, Olivia L. Brooks, Kyle M. Brooks, Carl D. Anthony, Cari-Ann M. Hickerson, Kelly A. Williams, Shawn R. Kuchta
Spatial Variation In Sexual Size Dimorphism And Mating Associations In The Color Polymorphic Eastern Red-Backed Salamander (Plethodon Cinereus), Maggie M. Hantak, Olivia L. Brooks, Kyle M. Brooks, Carl D. Anthony, Cari-Ann M. Hickerson, Kelly A. Williams, Shawn R. Kuchta
2025 Faculty Bibliography
Sexual selection due to mate preference for certain traits can maintain phenotypic diversity within populations and species. In taxa with discrete phenotypes, such as color polymorphic species, assortative mating may lead to disruptive selection and sympatric divergence, yet how such interactions vary over species' ranges remains poorly understood. To address this shortcoming, we examined spatial patterns of sexual size dimorphism and presumptive male–female mating pairs based on body size and coloration in the color polymorphic Eastern Red-backed Salamander, Plethodon cinereus. This species exhibits two common color morphs, striped and unstriped, that also differ in other elements of their biology, including …
Influence Of Multi-Species Data On Gene-Disease Associations In Substance Use Disorder Using Random Walk With Restart Models, Erich J. Baker, Everest U. Castaneda, Sharon Moore, Jason A. Bubier, Stephen K. Grady, Michael A. Langston, Elissa J. Chessler
Influence Of Multi-Species Data On Gene-Disease Associations In Substance Use Disorder Using Random Walk With Restart Models, Erich J. Baker, Everest U. Castaneda, Sharon Moore, Jason A. Bubier, Stephen K. Grady, Michael A. Langston, Elissa J. Chessler
Funded Scholarship
A major challenge lies in discovering, emphasizing, and characterizing human gene-disease and gene-gene associations. The limitations of data on the role of human gene products in substance use disorder (SUD) makes it challenging to transition from genetic associations to actionable insights. The integration of data from multiple diverse sources, including information-dense studies in model organisms, has the potential to address this gap. We demonstrate a modified performance of the Random Walk with Restart algorithm when multi-species data is integrated in the heterogeneous network within the context of SUD. Additionally, our approach distinguishes among disparate pathways derived from the Kyoto Encyclopedia …
Variation In Maternal Alkaloid Provisioning And Its Effects On Antimicrobial Defense In Tadpoles Of The Poison Frog Oophaga Pumilio, Erica Berent
Masters Theses
No abstract provided.
Genetic Influences On Individual Variability In Western Lowland Gorilla (Gorilla Gorilla Gorilla) Social Behavior, Hadley Mueller-Hill
Genetic Influences On Individual Variability In Western Lowland Gorilla (Gorilla Gorilla Gorilla) Social Behavior, Hadley Mueller-Hill
Master's Theses
While primates are considered highly social animals, the evolutionary origins and mechanisms underlying their social behaviors remain unclear. Not only do they exhibit an extensive range of behaviors, but individuals within the same species can also vary widely in their social interactions. Genetics play a significant role in shaping these individual variations in behavior; multiple genetic variants have been associated with differences in social behavior in mammals. Examples of these include MAOA and OXTR genes, which influence the expression of behaviors associated with antisocial and prosocial temperaments. Genetic polymorphisms affect primate interactions, impacting an individual’s ability to maintain its status …
Chironomids Shed Light On Organic Matter Dynamics In Macroinvertebrate Communities In Prairie Pothole Lakes In West-Central Minnesota, Usa, Tracey M. Anderson, Sarah G. Winikoff, Michael L. Sorensen, Melissa L. Rudeen
Chironomids Shed Light On Organic Matter Dynamics In Macroinvertebrate Communities In Prairie Pothole Lakes In West-Central Minnesota, Usa, Tracey M. Anderson, Sarah G. Winikoff, Michael L. Sorensen, Melissa L. Rudeen
Biology Publications
The Prairie Pothole Region (PPR) in North America is characterized by a high density of wetlands that can range from temporary habitats to small lakes. Much of the PPR has been converted to agriculture resulting in outright habitat loss, eutrophication, sedimentation, introduction of agrochemicals, and the introduction of invasive plants and animals. We compared two prairie pothole lakes, Cottonwood Lake and Page Lake, to assess the functional roles and trophic structure of the macroinvertebrate communities in this highly altered landscape. We collected macroinvertebrate samples from littoral and profundal regions of each lake with an Ekman grab sampler in winters of …
Navigating Wastewater: Minnesota Mining Wastewater Permit Challenges And Evolving Compliance Standards, Madelaine Adamich
Navigating Wastewater: Minnesota Mining Wastewater Permit Challenges And Evolving Compliance Standards, Madelaine Adamich
Journal of Earth and Life Science
February of 2021 marked the beginning of Minnesota clearly establishing that groundwater qualifies as a Class 1 water in a legal battle involving United States Steel, the Minnesota Pollution Control Agency, WaterLegacy, Fond du Lac Band of Lake Superior Chippewa, the Minnesota Court of Appeals, and eventually the Minnesota Supreme Court (MNSC). Minnesota has a water classification system, as required by the federal Clean Water Act, with 7 classes of use. Class 1 waters are waters used for domestic consumption (MPCA 4, n.d.). According to Minnesota Statute § 7050.0220, the acceptable level for sulfate is 250 mg/L in Class 1 …
Aquatic Invertebrate Populations In Roadside Wetlands In Relation To Water Characteristics, Ellen P. Isakson
Aquatic Invertebrate Populations In Roadside Wetlands In Relation To Water Characteristics, Ellen P. Isakson
Journal of Earth and Life Science
The continual habitat destruction and draining of wetland systems makes the need to understand the ecology of roadside wetlands all the more necessary. Roadside wetlands provide valuable habitat to countless aquatic invertebrates, which can provide insight into the health of the wetland system due to their diversity. The objective of this study was to analyze the populations of aquatic invertebrates in roadside wetlands in relation to water characteristics such as pH, salinity, conductivity, water depth and temperature, and dissolved oxygen. This was done by collecting samples of invertebrate populations from roadside wetlands, in addition to data on water quality characteristics …
Derivation Of The Maintenance Energy Requirements In Growing Jersey Heifers: Supplementary Table S1, Addison L. Carroll, Michael J. Vandehaar, Paul J. Kononoff
Derivation Of The Maintenance Energy Requirements In Growing Jersey Heifers: Supplementary Table S1, Addison L. Carroll, Michael J. Vandehaar, Paul J. Kononoff
Department of Animal Science: Faculty Publications
Supplemental table for Addison L. Carroll, Michael J. VandeHaar, and Paul J. Kononoff. Derivation of the maintenance energy requirements in growing Jersey heifers. Journal of Dairy Science (2025).
Introductory Biology Ii Lab Manual, Melissa A. Storm
Introductory Biology Ii Lab Manual, Melissa A. Storm
OER Collection
Explore the diversity of life on the planet Earth with a focus on organisms found in the Southeast of the United States, examine the evolutionary relationships between organisms and the ways in which scientists are currently expanding their understanding of those relationships every day through this BIO 102 Lab Manual
How to use this book:
Each unit of this book represents the information you will learn during a week of lab class. Within each unit you will find types of information to help you learn the content.
At the beginning of each unit, you will find lists of reinforced skills …
Examining Short Term Drainage Impacts To Soil Health In Hydric And Non-Hydric Soils Of Waseca County, Minnesota, Ely Hartl
All Graduate Theses, Dissertations, and Other Capstone Projects
Subsurface drainage is implemented throughout the Midwest United States to remove excess moisture from soil to enhance crop growth. Hydric soils are ubiquitous throughout Minnesota and are commonly drained due to their historically saturated conditions. Changing a soil's hydrology can impact its formation and properties. The alteration of physical, biological, and chemical soil properties can occur to both hydric and non-hydric soils, impacting overall soil health. The purpose of this study is to examine the short-term effects of tile drainage on the soil health of hydric and non-hydric soils in southern Minnesota. Research methods include: 1) collect soil-sediment cores to …
Elucidating The Non-Shivering Thermogenesis Response In The Black-Capped Chickadee (Poecile Atricapillus), Sweta Chand
Elucidating The Non-Shivering Thermogenesis Response In The Black-Capped Chickadee (Poecile Atricapillus), Sweta Chand
Dissertations and Theses
The adaptation of small birds to cold environments involves mechanisms for both heat conservation and heat generation. While minimizing heat loss reduces the energy needed to maintain body temperature, thermogenesis remains essential. Shivering and non-shivering thermogenesis (NST) are two likely mechanisms supporting cold adaptation in small avian species. Although sarcolipin (SLN) aids NST in small mammals, studies in birds such as Dark- eyed Juncos have shown no increase or even a decrease in SLN expression during cold exposure, suggesting limited involvement. This may reflect biological differences or limitations of mRNA- focused sequencing, which excludes long non-coding RNAs (lncRNAs) capable of …
Diversification Of Avifauna In The Darién Highland Region: Ecological Niche Modeling, Phylogeography And Morphology To Explore Speciation In The Montane Species Myadestes Coloratus, Chlorospingus Tacarcunae And Margarornis Bellulus., Jorge L. Garzon Vasquez Mrs
Diversification Of Avifauna In The Darién Highland Region: Ecological Niche Modeling, Phylogeography And Morphology To Explore Speciation In The Montane Species Myadestes Coloratus, Chlorospingus Tacarcunae And Margarornis Bellulus., Jorge L. Garzon Vasquez Mrs
Theses and Dissertations
Montane regions in the Neotropics are hotspots of endemism and biodiversity, yet their species are especially vulnerable to the impacts of climate change and geographic isolation. This thesis investigates the evolutionary and ecological dynamics of three bird species endemic to the Darién Highlands of eastern Panama: Myadestes coloratus, Chlorospingus tacarcunae, and Margarornis bellulus. Through an integrative approach combining ecological niche modeling, morphometric analysis, and genomic data from ultraconserved elements (UCEs) and mitochondrial DNA, the study explores the historical biogeography, current distribution patterns, population structure, and phenotypic differentiation of these montane taxa. Ecological niche models revealed that suitable habitat …
Mctr3 Mitigates Cigarette Smoke-Induced Pulmonary Inflammation And Damage, Yu Par Aung Myo
Mctr3 Mitigates Cigarette Smoke-Induced Pulmonary Inflammation And Damage, Yu Par Aung Myo
Theses and Dissertations
Smoking is deleterious to our lungs and can precipitate in a multitude of diseases, including chronic obstructive pulmonary disease (COPD). COPD is primarily caused by smoking cigarettes and is a major public health issue. Current therapies only treat symptoms without halting or reversing disease progression, thus highlighting a large unmet need to develop new therapies. We address this gap by investigating maresin conjugate in tissue regeneration 3 (MCTR3) which is a newly discovered specialized pro-resoling mediator (SPM) that has the novel property of promoting tissue repair and regeneration in addition to being anti-inflammatory and pro-resolving. For the first time, we …
Critical Environmental Communication Framework, Shumaila J. Bhatti, Srivi Ramasubramanian, Andrea Feldpausch-Parker, Bruno Takahashi, Silje Kristiansen
Critical Environmental Communication Framework, Shumaila J. Bhatti, Srivi Ramasubramanian, Andrea Feldpausch-Parker, Bruno Takahashi, Silje Kristiansen
Media Studies - All Scholarship
This study develops a Critical Environmental Communication (CEC) framework to assess the landscape of Environmental Communication research and to what extent and in which ways critical and justice-oriented perspectives are included. The CEC framework consists of four interconnected themes: (a) Marginalized Ecocultural Identities, (b) Context and Scale, (c) Power and Agency, and (d) Justice, Equity, Diversity, Access, and Inclusion (JEDAI). Using this framework in a bibliometric analysis examining 1,297 Environmental Communication publications, we assess the occurrence of these themes in the scholarship. Our analysis found that Marginalized Ecocultural Identities, and Context and Scale were most frequently occurring, while Power and …
Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov
Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov
Bioelectrics Publications
Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC₅₀) after electroporation ranged from <1 nM to about 100 nM. For intact cells, the EC₅₀ was unattainable even at the highest gelonin concentration of 1000 nM, which reduced cell survival by only 5–15%. For isoeffective electroporation treatments using 300 ns, 9 µs, and 100 µs pulses, longer pulses were more efficient at lowering gelonin EC₅₀. Increasing the electric field strength of 8, 100 µs pulses from 0.65 to 1.25 kV/cm reduced gelonin EC₅₀ from 128 nM to 0.72 nM. Conversely, the presence of 100 nM gelonin enabled a more than 20-fold reduction in the number of pulses required for equivalent cell killing. Pulsed electric field-mediated delivery of gelonin shows promise for hyperplasia ablation at concentrations sufficiently low to minimize or avoid systemic toxicity.
Instructions For Authors, Discovery Editors
Instructions For Authors, Discovery Editors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta
Characterizing A Rad23 Dependent Ultraviolet Radiation Resistance In Tetrahymena Thermophila, Emma June Liimatta
Graduate Theses/Dissertations
In 2020, 10 million deaths were attributed to cancer, with multidrug resistance being responsible for over 90% of deaths in cancer patients receiving treatment. This study utilized the model organism Tetrahymena thermophila to study how cells become resistant to Ultraviolet Radiation (UV) radiation, a process similar to multidrug resistance, specifically focusing on the nucleotide excision repair and ubiquitin shuttle protein Rad23. The National Cancer Institute documented 30-60% of cancers tested had a mutation in RAD23. Knockdown of RAD23 in Tetrahymena thermophila demonstrated a UV resistance phenotype with decreased nucleotide excision repair and differential expression of proteins active within caspase-independent …