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Assessing The One Health (Ecosystem, Animal And Human Health) Impacts Of Current Dietary Patterns Based On Farm-To-Fork Life Cycle Assessment In The Republic Of Ireland, Daniel Tymko Burke, Paul Hynds, Anushree Priyadarshini

Articles

Food production and dietary patterns play a central role in the myriad interactions among human, animal, and environmental health, emphasising the need for a One Health approach, and this study aims to evaluate dietary patterns within this framework. A cross-sectional dietary survey of adults was undertaken (2021) with a sample size of 957 respondents, representative of the population of Ireland. Subsequently, a farm-to-fork life cycle assessment (LCA) was employed to assess nine human health and environmental impacts (fine particulate matter formation, freshwater and marine ecotoxicity and eutrophication, human carcinogenic and non-carcinogenic toxicity and terrestrial acidification and ecotoxicity) across thirteen distinct …

Tobacco Smoke Exposure Is A Driver Of Altered Oxidative Stress Response And Immunity In Head And Neck Cancer, Yang Li, Pedram Yadollahi, Fonma N Essien, Vasanta Putluri, Chandra Shekar R Ambati, Karthik Reddy Kami Reddy, Abu Hena Mostafa Kamal, Nagireddy Putluri, Lama M Abdurrahman, Maria E Ruiz Echartea, Keenan J Ernste, Akshar J Trivedi, Jonathan Vazquez-Perez, William H Hudson, William K Decker, Rutulkumar Patel, Abdullah A Osman, Farrah Kheradmand, Stephen Y Lai, Jeffrey N Myers, Heath D Skinner, Cristian Coarfa, Kwangwon Lee, Antrix Jain, Anna Malovannaya, Mitchell J Frederick, Vlad C Sandulache

Faculty, Staff and Student Publications

Background: Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data show cigarette smoke to be a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and suppressed anti-tumor immunity. We sought to determine whether smoke itself can modulate aggressive tumor behavior in head and neck squamous cell carcinoma (HNSCC) through reprogramming of the cellular reductive state.

Methods: Using established human and murine HNSCC cell lines and syngeneic mouse models, we utilized conventional western blotting, steady state and flux metabolomics, RNA sequencing, quantitative proteomics and flow cytometry to …

Anticancer Activity Of Allium Cepa Through The Inactivation Of Nf-Κb Pathway: A Literature-Based Study, Sharmita Ghosh Situ, Md. Sakib Al Hasan, Emon Mia, Md. Nasimul Haque Shipon, Md. Faisal Amin, Asmaul Husna Bristy, Yasin Emon

School of Integrative Biological & Chemical Sciences Faculty Publications

Allium cepa (onion) is a bulbous herb renowned for its diverse health benefits. This study aims to summarize the anticancer potential of A. cepa through the inactivation of the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway by reviewing experimental findings across various cancer models. A thorough examination of the literature was carried out using databases like Google Scholar, PubMed, Web of Science, and ScienceDirect. The findings revealed that phytochemicals such as stigmasterol, fisetin, quercetin, isorhamnetin, morin, kaempferol, luteolin, β-carotene, and β-sitosterol exhibit strong anticancer properties against various cancers, including breast, bladder, colon, colorectal, cervical, lung, liver, oral, pancreatic, …

17 - Mapping The Spatial Distribution Of Submerged Aquatic Vegetation Using Commercial Satellite Imagery, Brandon Watson

Undergraduate Research Symposium

Seagrass in the Chesapeake Bay has seen an increase due to restoration efforts since the 90s, but with the extreme change of climate, we are unsure if the seagrass will thrive or perish, and where it will occur in the bay. Seagrass stabilizes coastal sediments, reducing erosion and protecting shorelines. It provides crucial habitats and nursery grounds for a diverse range of marine species, supporting both biodiversity and fisheries. Additionally, they play a significant role in carbon sequestration, which mitigates the effects of climate change. This study specifically looked at the area from the mouth of the Rappahannock River up …

Highly Regenerable Magnetic Sulfonated Chitosan Crosslinked With Glutaraldehyde Composite Beads (Iron Sand/Naso3-Chi-G) For Aqueous Mercury Removal, Fathurrahmi Fathurrahmi, Rahmi Rahmi, Lelifajri Lelifajri, Anggun Sixthia Wulan Ayu, Muhammad Iqhrammullah

Karbala International Journal of Modern Science

We developed a novel adsorbent from sulfonated, glutaraldehyde-crosslinked chitosan embedded with magnetic iron sand. The adsorbent was synthesized through a two-step process: (1) sulfonation with N(SO₃Na)₃ to introduce sulfonate groups, and (2) crosslinking with glutaraldehyde to enhance structural stability. The optimal formulation, containing 43.5% iron sand and crosslinked with 0.17 M glutaraldehyde, exhibited the highest Hg²⁺ adsorption capacity (30.74 mg/g) at pH 3. The adsorbents were characterized using Scanning Electron Microscopy (SEM), Fourier transform infra-red spectroscopic (FT-IR), and X-ray diffraction (XRD) techniques. Adsorption equilibrium was achieved within 60 minutes, and isotherm modeling showed that the process followed the Freundlich model …

Atlantic Sharpnose Shark (Rhizoprionodon Terraenovae) Jaw, Nicholas Burchett, David Kerstetter, Derek Burkholder

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Assessing A Possible Effect Of Males' Pheromones In The Phonotaxis Of Female Acheta Domesticus, Addy Rodriguez Velasco

Honors Theses

Acoustic communication in crickets is crucial for reproduction. Females respond phonotactically to the male's call. Prior research evaluating the selectivity of phonotaxis in these females, has focused on females that have been isolated from males from day 1 after metamorphosis. However, assessing phonotaxis in females raised in the presence of males, remains to be done. This study aims to investigate the phonotactic response of female Acheta domesticus that were housed with males prior to testing.

Results indicate that on average, male-exposed females respond phonotactically to a wider range of calls that those females in the control group. These results rule …

Understanding Strain-Level Dynamics In Gut Commensal-Pathogen-Host Interactions, Anna Louise Deveaux

Arts & Sciences Graduate Student Theses and Dissertations

The human gut microbiome is a consortium of trillions of bacteria, archaea, fungi, and viruses that colonizes the gastrointestinal tract and promotes health under homeostatic conditions. This microbial community trains the immune system, modulates inflammation and anticancer immunity, promotes cardiometabolic health, enables nutrient extraction, and prevents pathogen overgrowth. The latter function manifests through colonization resistance, in which microbes occupy spatial and nutritional niches thereby excluding pathogens from the community entirely, and through limiting pathogen population growth if colonization occurs. These roles are facilitated by complex host-microbe and microbe-microbe interactions that underlie differences in susceptibility to microbiome-mediated infectious diseases. The strain-level …

Anti-Proliferative Potential Of Plant Extracts: A Study Of Guarana, Apple Peel, Milk Thistle, Elderberry, And Barberry, Randi Childress, Lauren Fisk, Andrew Fleury, Khole Hester, Ty Hulshof, Laura Nelsen, Dane Schoenborn, Gershom Srinivasulu, Alexa Trover, Julia Vandenberg, Brianna Winford, Sara S. Tolsma

Celebration of Research

Plant-based compounds have garnered interest as alternative and adjunct cancer therapies due to their anti-proliferative properties. This study examines the effects of guarana (Paullinia cupana), apple peel (Malus domestica), milk thistle (Silybum marianum), elderberry (Sambucus nigra), and berberis (Berberis vulgaris) on HeLa cell proliferation. Using in vitro CyQuant assays, we assessed their impact at varying concentrations. Results indicate that guarana and apple peel extracts may exhibit anti-proliferative activity, with guarana acting synergistically with paclitaxel. We believe the extracts are likely acting through oxidative stress modulation, apoptosis induction, and cell cycle disruption (Cavalcanti et al., 2020; Hertz, 2015; Khan et al., …

Assessment Of Bumblebee Populations Using Bee-Bowls And Mark-Recapture Methods, Kleyton Degroot, Gideon Fynaardt, Sharon Huffman, J.T. Klinghagen, Yuki Kobayashi, Olivia Lott, Laura Nelsen, Victoria Pavik, Garrett Snyder, Laura Furlong, Todd Tracy

Celebration of Research

The ecological services of insect pollinators are well established; therefore, the documented decline in pollinator biodiversity is of great global and local concern. Using two survey methods, our study provides baseline pollinator community data at two conservation sites in Northwest Iowa. In September of 2023, we used three colors (blue, yellow, and white) and two depths (shallow and deep) of bowl traps to investigate pollinator communities at a small prairie restoration site (Buena Vista County Park) and a nearby native prairie (The Nature Conservancy Glacial Hills Preserve). Employing modifications of the protocol suggested by the Bumble bee Atlas to collect …

Atlantic Sharpnose Shark (Rhizoprionodon Terraenovae) Neurocranium, Michelle Bassali, David Kerstetter, Ema Nagel

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Atlantic Sharpnose Shark (Rhizoprionodon Terraenovae) Jaw, Michelle Bassali, David Kerstetter, Ema Nagel

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

The Effects Of Diluted Fungicide On Western Tiger Salamander (Ambystoma Mavortium) Health, Sage Veomett

Honors Program: Senior Projects (Public)

The Western Tiger Salamander (Ambystoma mavortium) is a species of salamander that is native to Nebraska. The Western Tiger Salamander population has been in decline, specifically in Southeast Nebraska (Ferraro, 2016). The purpose of this study was to determine whether low levels of Azoxystrobin fungicide deposited in the soil are harmful to the Western Tiger Salamander. In this study, soil in tanks containing pairs of Western Tiger Salamanders was treated with levels of Azoxystrobin 0.5x under the recommended label amount for usage. Fifteen salamanders in total were used. Four tanks of salamander pairs were treated with the Azoxystrobin …

Phylogenetic Relationships And Species Delimitation Of Bunchgrass Lizards Of The Genus Sceloporus From Mexico With The Description Of A New Species, Tristan Charran, Jesús A. Loc-Barragan, Rafael Alejandro Calzada-Arciniega, Liz A. Alfaro-Juantorena, Raúl Cueva Del Castillo, Christopher Blair, Víctor H. Jiménez-Arcos

Publications and Research

Molecular data continue to serve as an invaluable tool to assess species limits and patterns of cryptic diversity, particularly in areas harboring high levels of biodiversity. The Sceloporus scalaris group, known as bunchgrass lizards, contains 13 described and one undescribed species distributed throughout high elevation biotas of Mexico. However, recent studies suggest that diversity in the group may be substantially underestimated. We collect new sequence data from four independent loci to determine the evolutionary distinctiveness and phylogenetic relationships of an isolated population of bunchgrass lizard in the Sierra San Juan (SSJ) in the Mexican state of Nayarit. Concatenation and coalescent-based …

Dissecting The Contribution Of Stmn2 To Als Pathogenesis, Kelsey Krus

Arts & Sciences Graduate Student Theses and Dissertations

TDP-43 is required for splicing of Stathmin-2 (STMN2) transcript, so STMN2 is reduced in most ALS patients. TDP-43 does not regulate STMN2 in mice as it does in humans. Thus, mouse models of ALS do not reflect patient loss of STMN2. To test the hypothesis that a reduction in STMN2 contributes to ALS pathogenesis, we generated STMN2 knockout mice. Constitutive STMN2 loss induces an early sensory and motor neuropathy with disrupted motor behavior and dramatic distal neuromuscular junction (NMJ) denervation. This NMJ pathology occurs in fast-fatigable motor units, which are the most vulnerable in ALS. In contrast, motoneurons and axons …

Reproductive Performances Of Bali Cattle Under Different Management Systems For Designing Their Breeding Strategies, Dwi Hariyono, Panjono Panjono, Dwi Priyadi, Adisti Rastosari, Eny Endrawati, Tety Hartatik

The Thai Journal of Veterinary Medicine

Reproductive performance is an economically important trait in beef cattle breeding and improvement programs, as it directly influences overall productivity. Key performance indicators, such as age at puberty (AP), age at first mating (AFM), age at first calving (AFC), calving intervals (CI), days open (DO), number of services per conception (NSC), conception rate (CR), and gestation length (GL), can be used to assess reproductive performance. This review summarized findings from previous studies on the reproductive performance of Bali cattle under various management conditions in Indonesia. The literature indicated a range of reproductive performances in Bali cattle, with AP varying from …

The Role Of Vibration Amplitude In The Escape-Hatching Response Of Red-Eyed Treefrog Embryos, Julie Jung, Michael S. Caldwell, Gregrory Mcdaniel, Karen Warkentin

Biology Faculty Publications

Red-eyed treefrogs hatch early when attacked by snake or wasp egg predators. They use vibrations generated by attacks to identify these threats but other, harmless environmental disturbances also produce strong vibrations within egg clutches. This study examines the complex ways embryos use vibrations amplitude information to ensure they hatch only when a real threat is present.

Elucidating The Antibiofilm Characteristics Of A Carbon Infiltrated Carbon Nanotube Surface And A Copper-Coated Carbon Infiltrated Carbon Nanotube Surface, Lucy Christena Bowden

Theses and Dissertations

Post-surgical implant-associated infections cause considerable patient morbidity and mortality. These infections are often caused by biofilm-forming bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. Bacterial biofilms are resistant to immune clearance and are a reservoir of antibiotic resistance. Implant materials that resist bacterial colonization may be able to improve patient outcomes. Carbon infiltrated carbon nanotubes (CICNT) are a potential surface modification for medical implants. The work presented in this dissertation focuses on characterizing the antibiofilm effect of the CICNT surface, better understanding its mechanism of action, and characterizing the enhanced antibiofilm effect of a copper-coated CICNT surface. S. aureus biofilms …

Chronic Viral Mimicry Induction Following P53 Loss Promotes Immune Evasion, Charles A Ishak, Sajid A Marhon, Naïri Tchrakian, Anjelica Hodgson, Helen Loo Yau, Isabela M Gonzaga, Melanie Peralta, Ilinca M Lungu, Stephanie Gomez, Sheng-Ben Liang, Shu Yi Shen, Raymond Chen, Jocelyn Chen, Biji Chatterjee, Kevin N Wanniarachchi, Junwoo Lee, Nicholas Zehrbach, Amir Hosseini, Parinaz Mehdipour, Siyu Sun, Alexander Solovyov, Ilias Ettayebi, Kyle E Francis, Aobo He, Taiyi Wu, Shengrui Feng, Tiago Da Silva Medina, Felipe Campos De Almeida, Jane Bayani, Jason Li, Spencer Macdonald, Yadong Wang, Sarah S Garcia, Elisa Arthofer, Noor Diab, Aneil Srivastava, Paul Tran Austin, Peter J B Sabatini, Benjamin D Greenbaum, Catherine A O'Brien, Trevor G Shepherd, Ming Sound Tsao, Katherine B Chiappinelli, Amit M Oza, Blaise A Clarke, Robert Rottapel, Stephanie Lheureux, Daniel D De Carvalho

Faculty, Staff and Student Publications

Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood. In this report, we characterize premalignant lesions of the fallopian tube along with syngeneic epithelial ovarian cancer models to explore the earliest events of tumorigenesis following loss of the p53 tumor suppressor protein. We report that p53 loss permits transcription of immunogenic repetitive elements and chronic viral mimicry activation …

Bone-Induced Her2 Promotes Secondary Metastasis In Hr+/Her2- Breast Cancer, Rahat Alam, Anna Reva, David G Edwards, Bree M Lege, Laura S Munoz-Arcos, Carolina Reduzzi, Swarnima Singh, Xiaoxin Hao, Yi-Hsuan Wu, Zeru Tian, Laura M Natalee, Gargi Damle, Deniz Demircioglu, Yixian Wang, Ling Wu, Elisabetta Molteni, Dan Hasson, Bora Lim, Zbigniew Gugala, Jerry E Chipuk, Julie E Lang, Joseph A Sparano, Chonghui Cheng, Massimo Cristofanilli, Han Xiao, Xiang H-F Zhang, Igor L Bado

Faculty, Staff and Students Publications

Bone metastases can disseminate to secondary sites and promote breast cancer progression creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction power of Her2-expressing (Her2E) circulating tumor cells (CTCs) after analyzing over 13,000 CTCs from a cohort of 137 metastatic breast cancer (MBC) patients with initial HR+/Her2− status and employ preclinical models of bone metastasis (BM) to validate the role of Her2E CTCs in multi-organ metastases. While Her2 expression was higher in patients with bone metastasis, experimental analyses revealed that Her2E CTCs derived from bone lesions were more dependent on Her2 …

Metabolic Transitions In Embryos Of Artemia Franciscana: Regulation And Consequences For Oxidative Stress, Daniel Anthony Arabie

LSU Doctoral Dissertations

Embryos of Artemia franciscana survive harsh conditions in diapause and anoxia-induced quiescence for years by undergoing deep metabolic transitions. I investigated the relationship between phosphorylation of pyruvate dehydrogenase (PDH) and carbon flux to the tricarboxylic acid (TCA) cycle during metabolic depression. The difference in catalytic activity of the PDH complex (PDC) in maximally phosphorylated and dephosphorylated samples was 16.5-fold. Western blot analysis confirmed the changes in phosphorylation of PDH. Analysis of PDH expression in diapause and post-diapause embryos via phospho-PDH showed no significant differences. Investigation of post-diapause embryos under anoxia showed that phosphorylation of PDH decreased and activated the enzyme. …

The First Record Of Alpiscorpius Idaeus (Yağmur & Tropea, 2017), Comb. N. From The Lesvos Island, Greece (Scorpiones: Euscorpiidae), Ersen A. Yağmur, Özgün Sipahioğlu

Euscorpius

The scorpion species Euscorpius idaeus Yağmur & Tropea, 2017, previously known from Mount Kazdağı in the Balıkesir and Çanakkale Provinces of Turkey, is reported for the first time from the Lesvos Island, Greece. In this study, it is transferred to the genus Alpiscorpius Gantenbein et al., 1999. Detailed illustrations of Alpiscorpius idaeus (Yağmur & Tropea, 2017), comb. n. from the Lesvos Island population are provided.

The Role Of Moonlighting Proteins In Life Through Viewing A Synthetic Mycoplasma Species, Anthony Wheeler, James Daubenspeck, Prescott Atkinson

Expo Student Presentations

2025 Spring Expo Oral Presentation

• Biological & Life Sciences
• Works in Progress

Age Related Variations In Blood Vessel Vascularity And Collagen Deposition In Mice Ovarian Tumors, Khushi Sureja, Asha Kumari, Mehri Monavarian, Liz Quientero-Macias, Karthikeyan Mythreye

Expo Student Presentations

2025 Spring Expo Poster Presentation

• Biological & Life Sciences

Impact Of O-Glcnacylation Elevation On Mitophagy In Astrocytes Within The Dentate Gyrus, Eric Rohwer, Joshua Kramer, John C. Chatham, Martin E. Young, Victor Darley-Usmar, Jianhu Zhang

Expo Student Presentations

2025 Spring Expo Poster Presentation

• Biological & Life Sciences
• Works in Progress

Stress-Induced Neural Activity In The Pvt And Its Role In Binge Eating Behavior, Julia Tucker, Sierra Miller, Lauren Assaf, Sofia Beas

Expo Student Presentations

2025 Spring Expo Poster Presentation

• Biological & Life Sciences

Summer Air Temperature Comparisons Between The Field And Woods In An Angus Beef Cattle Silvopasture In The Virginia Coastal Plain, Amy E. Edwards

Virginia Journal of Science

The objective of this study was to compare corresponding temperature readings from loggers in the field and woods in a silvopasture for Angus beef cattle. Results show that temperatures during the hottest part of the day are greater in the field than in the woods. Summary statistics show higher maximum, upper quartile, and median temperatures at the field logger with all data analyzed, indicating the temperatures in the field are overall higher than the woods, except during temperature inversions at nighttime. This highlights the importance of providing cattle with shade to prevent heat exhaustion and thermal stress, especially when the …

Fisheries Management Paper No.286: Western Australian Octopus Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

Harvest strategies for Western Australia’s (WA) aquatic resources are formal documents developed to support decision-making processes that ensure the outcomes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002a) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012). Harvest strategies are a key component of all contemporary fishery management systems and a requirement for certification under the Marine Stewardship Council (MSC). The objectives of ESD are reflected in the objectives of the Fish Resources Management Act 1994 (FRMA).

This Octopus Resource Harvest Strategy (Harvest Strategy) has been developed and revised in line with the Harvest Strategy …

Research Day 2025 Program, Western Michigan University Homer Stryker M.D. School Of Medicine

Research Day

No abstract provided.

Native Maintenance Booklet, Plaster Creek Stewards

Print Materials

Your new garden is an ecological haven for pollinators. By replacing grass with native plants, you will be providing food and a resilient habitat for bees, butterflies, birds, and so much more. Many of our native insects rely on these native plants to survive and reproduce, and many birds rely on these insects to reproduce and feed their young. By bringing these plants back into our yards, we are giving them a huge helping hand. This booklet provides details on maintaining Michigan native landscapes, including recommended maintenance schedules, identifying native plants versus weeds, and garden advocacy suggestions.