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Effects Of Novel Dopamine D4 Receptor-Targeted Compounds On Locomotor Activity And Anxiety-Like Behavior In Male And Female Sprague Dawley Rats, Samantha Alyse Walkow, Noah A. Ivak, Daniel Chandler, John Tkaczynski, Thomas M. Keck, Comfort A. Boateng, Eleni Papadopoulos, Barry D. Waterhouse, Rachel L. Navarra

Rowan-Virtua Research Day

The consequences of modulating subtypes of G protein coupled dopamine receptors are broadly studied for their role in decision making behavior, specifically in situations involving uncertain risk and reward. The actions of dopamine D4 receptors (D4Rs) on these complex processes are the least understood, particularly due to a lack of available compounds with suitable selectivity for D4Rs. Further, current research often fails to evaluate how modulating specific dopamine receptor subtypes may affect locomotor activity and anxiety-like behavior as confounding factors prior to assessing their function in behavioral assays of higher order decision making. The goal of the current study was …

Characterizing Environmental Background Microflora And Assessing Their Influence On Listeria Persistence In Dairy Processing Environment, Vaishali Poswal, Sanjeev Anand, Brian Kraus

Dairy Science and Food Science Faculty Publications: 2022 to Present

Listeria monocytogenes (Lm) may persist in food processing environments (FPEs) alongside diverse background microflora. While microbial communities in FPEs can in- fluence Lm survival, their role in supporting or suppressing its growth remains unclear. This study aimed to characterize the microflora in floor swabs and air samples collected from a dairy processing facility across three seasons and assess their potential impact on the growth of a Lm test strain previously isolated from a dairy processing environment. A total of 167 environmental isolates, representing 30 bacterial genera, were identified. Pseudomonas was consistently prevalent across all sample types. Seasonal shifts in bacterial …

Investigating Fatty Acid Influence On West Nile Virus In Mosquitoes And Birds, Hayley Moree

Honors Program: Senior Projects (Public)

Vector-borne diseases, including Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), pose considerable global health threats, accounting for over 400 million infections and more than 700,000 deaths annually. Many vector-borne diseases are within the Flaviviridae family. Despite this, effective treatments have not been found for some flaviviruses. Flaviviruses exploit host cellular machinery to facilitate their replication and survival, reprogramming metabolic pathways, including lipid metabolism. Lipids play essential roles in the viral life cycle, providing structural components for the viral envelope, enabling membrane rearrangements for replication complexes, and supplying energy resources necessary for particle assembly.

Targeting lipid metabolism …

Effects Of Intradermal Injections Of Lipopolysaccharide On The Local And Systemic Acute Inflammatory Responses In Turkeys, Delaney F. Roberts

Poultry Science Undergraduate Honors Theses

In chickens, the growing feather (GF) pulp has been established as a cutaneous bioassay to monitor and assess tissue/cellular immune activities in response to intradermal (i.d.) injections of test materials. The objective of this pilot study was to determine the suitability of the GF bioassay in turkeys by examining the acute inflammatory responses initiated by i.d. GF-pulp injections of lipopolysaccharide (LPS). For this, three, 5-wk-old turkey poults were used. Two poults had 8 GFs injected (10 μL/GF) with low (L)-LPS (0.1 μg/GF) and 8 GFs with high (H)-LPS (1 μg/GF), while a third poult had 8 GFs injected with endotoxin-free …

The Movement Ecology, Ranging Patterns, And Territoriality Of Azara’S Owl Monkeys (Aotus Azarae) In The Argentinean Chaco Forest, Jeremy D. Pustilnik

Master of Environmental Science Theses

Azara’s owl monkeys (Aotus azarae) are small, pair-living, socially monogamous primates that inhabit the Chaco Forest of South America. Their activity and life history patterns have been particularly well studied, however, their movement ecology and ranging patterns within their home ranges remains largely unknown. Herein I descriptively analyze these patterns with respect to time, space, ambient environment, and physical environment using spatial information on five owl monkey groups that were followed over the course of a year between 1998 and 1999 at a multi-decade-operating field site near Formosa, Argentina. Analysis of distance and speed moved during different diel …

Empowering Diversity: A Comprehensvie Approach To Minority Risk Management Education, Jahqethea Johnson

Applied Science Program: Theses

Federal programs are pivotal to the foundation of the United States agricultural sector. Program payments impact the economic well-being of agricultural producers, yet accessibility, outreach and education disparities remain prevalent among socially disadvantaged producer and agriculturists. From 2020-2024, an average of $21.7 billion dollars in federal agricultural payments have been paid to producers. Although federal funding historically supports commodity crops, livestock producers also depend on a distinct set of federal risk management programs, which are often less visible but pertinent for operational sustainability. There is a growing focus on the need for addressing disparities faced by socially disadvantaged producers and …

The Great Animal Rights Debate: From The Past Into The Present, Dayna Wiley

Celebrating Scholarship and Creativity Day (2018-)

Animal rights are not a novel concept, and everyone has their own beliefs about where animals should fit into the hierarchy of life. Not so different from today, a debate occurred in the ancient world between the Stoics, represented by Aristotle, and Plutarch, with each questioning whether animals are capable of rational thought or feelings, and therefore whether they are deserving of justice. There is much to learn from the ancient world about the modern debate on animal rights, and there is a striking comparison between this ancient debate and the modern questions of animal rights. But how similar are …

Investigation Into The Microbiome Of Blow Fly Eggs Using Microseqtm Id, Samantha S. Davis, Drusilla Sheridan, Jennifer Rosati

Undergraduate Research

There is little published research characterizing the microbiome associated with blow fly eggs and how they may affect the colonization behaviors of certain blow fly species. Once deposited, blow fly eggs are rapidly introduced to a diverse range of microorganisms, which can vary depending on the species of blow fly, the environment, and the decomposition stage of the substrate (Junqueira et al., 2017). Since blow flies are among the first insects to colonize decomposing remains, the microbial communities present on their eggs could serve as key indicators of the decomposition stage at the time of egg-laying, thus providing a potential …

Decoding Oncology-Focused Biotechnology Firms: Lifecycle Analysis And Predictive Insights For Valuation From A Junior Associate's Perspective, Kesav P. Chandrasekhar

Finance Undergraduate Honors Theses

Oncology-focused biotechnology firms present unique valuation challenges due to high R&D costs, long development timelines, and uncertain clinical outcomes. This thesis addresses such challenges by integrating the clinical development lifecycle with financial valuation models to provide predictive insights into company value. A structured framework is developed that primarily focuses on stage-specific probabilities of success (PoS) for drug candidates and their impact on firm valuation, embedded in techniques such sum-of-the-parts (SOTP) analysis. By quantitatively linking clinical trial phases and likelihoods of approval to cash flow projections, the model enables a more realistic, risk-adjusted estimation of a biotech firm's worth. Through lifecycle …

Investigating Stress Hormone Variations In Green Frogs (Lithobates Clamitans) During The Mating Season, Abby Mciver

Electronic Theses and Dissertations

Monitoring stress hormones in wildlife populations is increasingly used to understand how human activities may impact the environment. The goal of this study was to quantify corticosterone in green frogs (Lithobates clamitans) at baseline levels and in response to an acute stressor throughout the mating season. The project was conducted from May to September of 2024 at Bays Mountain Park in Kingsport, Tennessee. Corticosterone levels were determined over six consecutive days each month from May to September using a non-invasive dermal swab technique. Additionally, body metrics, water chemistry, and weather and habitat conditions were evaluated on each sampling …

Impacts Of Temperature Acclimation On Swimming Performance And Metabolic Dynamics Of The Amargosa River Pupfish, Cyprinodon Nevadensis Amargosae, Teresa E. Guerre

Master's Theses

Climate change is leading to warmer atmospheric temperatures in many regions of the world, which in turn is raising the temperatures of aquatic habitats and simultaneously shifting the frequency and severity of extreme precipitation events. In fishes, metabolic demands are higher under warmer conditions, while dissolved oxygen levels typically decline in warmer water. This mismatch may limit the ability of fishes to cope with high water flow events like floods that can occur following extreme rainfall. A few species of pupfishes (genus Cyprinodon) in the Death Valley region of California and Nevada, USA, occupy stream or river habitats with …

Is There A Difference In Bird Diversity Among Prairie And Lake Habitats In Central Minnesota?, Emmi Edel, Morgan Cromwell, Maddy Fuller, Preston Mcgraw

Celebrating Scholarship and Creativity Day (2018-)

Biodiversity plays an essential role in ecosystem stability. Habitat changes from human activities also threaten this role. Our study examined how habitat type and urbanization affect the number of birds and bird diversity across two campuses in central Minnesota. The first campus is rural Saint John’s University (SJU), and the second is suburban College of Saint Benedict (CSB). We predicted that more bird species would be in habitats with water than habitats without water bodies. We also predicted that bird species numbers would be more significant on SJU, which has a large natural area, which CSB lacks. Observations were conducted …

Positive Impact Of Mangroves On Periwinkle Snail (Littoraria Angulifera) Population Size, Anna Jones, Eva Kolbow, Lucy Petschel, Morgan Stone

Celebrating Scholarship and Creativity Day (2018-)

Mangroves play a crucial role as shoreline aquatic nurseries and provide infrastructure along bodies of water to protect inland areas from extreme weather and storm surges. Mangroves also provide a secure habitat for animals, and trap and filter pollutants. Their stilt roots provide shelter for fish species and are critical to the survival of many small species that use this ecosystem. We investigated mangrove periwinkle snail populations on the red mangrove species (Rhizophora mangle). Data was collected along Pigeon Creek, San Salvador Island, Bahamas in March 2025. We hypothesized that there is a relationship between mangrove density and snail population …

The Effect Of Anthropogenic Sound On Foraging Behavior In Bluegill Sunfish (Lepomis Macrochirus), Dayna Wiley

Celebrating Scholarship and Creativity Day (2018-)

Anthropogenic noise can have adverse effects on fish populations. High-amplitude noise can cause hearing damage and interfere with essential behaviors, including feeding, migration, and reproduction. Studies suggest that fish regularly exposed to boat noise in lakes exhibit different behavioral responses compared to populations in quieter environments. Bluegill sunfish (Lepomis macrochirus) were collected via angling from a “Quiet Lake” (Lake Sagatagan, Collegeville, MN) with no motor use, and a “Loud Lake” (Upper Spunk Lake, Avon, MN) with frequent motor use. Bluegill foraging behavior was examined in response to daily playback of motorboat traffic. Bluegill (n = 5 individuals per trial; n …

Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis

Biomedical Sciences ETDs

The ATP-dependent chromatin remodeler Cockayne syndrome protein B (CSB) is essential for maintaining genome integrity. Mutations in CSB are the primary cause of Cockayne syndrome (CS), a premature aging disorder with severe sun sensitivity and neurodevelopmental symptoms. However, the precise mechanisms underlying the disease etiology remain poorly understood. Given the critical roles of oxidative stress in aging and neurodegenerative disorders, this research sought to determine the mechanisms of CSB’s functions in oxidative DNA damage repair.

In the first aim, we investigated how CSB participates in PARP1/2-mediated oxidative DNA repair. We showed that PARP1 and PARP2 recruit CSB to oxidized chromatin …

Sympatric Behavior Of Tree Squirrels In An Urban Environment, Ryan L. Snyder

Undergraduate Honors Thesis Collection

The eastern gray squirrel (Sciurus carolinensis) and fox squirrel (Sciurus niger) are ubiquitous in urban ecosystems like university campuses despite the habitat loss and fragmentation often associated with urbanization. While populations of both species usually do not overlap in their native geographic ranges, gray and fox squirrels are sometimes forced into coexistence in urban habitats where fewer green spaces are available. The coexistence of both species at Butler University in Indianapolis, Indiana refutes the competitive exclusion principle, and niche partitioning is likely necessary for them to coexist. This study assessed the activity patterns of fox and gray squirrels at Butler …

Growing Confidence: Women Forest Landowner Workshops In Georgia, Neil R. Dingley Jr., Nicholas E. Fuhrman, Kris Irwin, Elizabeth Mccarty

Journal of Human Sciences and Extension

The number of female forest landowners (FFLs) has been growing throughout the United States. This growth demands educational outreach for a demographic that is often behind their male counterparts in experience and education. The purpose of this exploratory study was to design and host educational workshops geared towards FFLs and to answer the following questions using quantitative and qualitative methods: (1) Are the workshops changing FFLs’ confidence in land management? (2) What are FFLs’ intentions after attending workshops? (3) Does confidence or participants’ intentions with their land vary with demographics? (4) Are workshops providing a platform to start FFL social …

Biodegradable Active Packaging: Exploring The Antimicrobial Efficacy And Compostability Of Chitosan-Based Films, Rachel Mchugh

All Theses

The overarching purpose of this experiment is to create an active packaging component that has both antimicrobial and biodegradable properties specifically designed for poultry food products. For the scope of this study, the packaging component created would theoretically be used in conjunction with another material, such as a poultry tray which are commonly used for fresh poultry products. Based on the scope and purpose of this experiment, biopolymer films and coatings were considered after the initial literature review. Due to the goals of the packaging component, chitosan, a polysaccharide shown to have antimicrobial properties and an inherent ability to biodegrade, …

Design And Optimization Of Aquaculture Gear: Development Of A Cage-Integrated Reeling Mechanism For Oyster Farming, Felicity Bryant

Honors Theses

This project encompasses the design, fabrication, and testing of a cage-integrated reeling system aimed at reducing the physical labor required in oyster aquaculture at Bama Bay Oyster Farm, the last operational oyster farm in Mobile Bay. The proposed system includes two primary components: lightweight, modular oyster cages and a dual-winch reeling device for automated retrieval. Three cage prototypes—rectangular, oval, and hexagonal—were evaluated for structural performance and fabrication feasibility. The oval design was ultimately excluded due to practical fabrication limitations. The rectangular and hexagonal designs were fabricated using recycled materials and tested under the most extreme environmental conditions derived from years …

Inflammatory Response In Ucd200/206 Scleroderma-Prone Chickens To Intradermal Injection Of Silikon 1000, Katee L. Johnson

Animal Science Undergraduate Honors Theses

Intradermal injections of silicone materials have resulted in chronic inflammation and fibrotic reactions in some individuals. The UCD200/206 line of chickens is characterized by spontaneous development of scleroderma/systemic sclerosis (SSc), a fibrotic autoimmune disease. This longitudinal study examined the cellular inflammatory activity initiated by SILIKON 1000 (a silicone product used as a filler in human skin) at the site of intradermal (i.d.) injection and in the peripheral blood in the SSc-prone UCD 200/206 (UCD) chickens and healthy White Leghorn (WL) controls. Specifically, the pulps of growing feathers (GFs) were i.d. injected with SILIKON or endotoxin-free, sterile PBS (8 and 3 …

The Effect Of 1,25-Dihydroxyvitamin D3 Supplementation On Humoral Immunity Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens, Bailey Herberger

Animal Science Undergraduate Honors Theses

Bacterial chondronecrosis with osteomyelitis (BCO) lameness, the most predominant locomotive illness in fast-growing broilers, causes substantial animal well-being issues and affects broiler production, leading to huge financial losses. Several strategies, including feed supplementations using organic trace minerals, vitamin D, probiotics, and prebiotics, have been utilized to alleviate BCO lameness incidences in broiler chickens. Previous studies have indicated that feeding an additive of Panbonis^®-G-1,25(OH)₂D₃ from Solanum glaucophyllum containing 1 µg/kg G-1,25(OH)₂D₃ to broilers for the first 28 days of their production cycle reduced BCO lameness by more than 50%. In this study, we …

Influence Of Gossypol From Cottonseed Meal Fed To Pregnant Sows On Seminiferous Tubule Diameters In Male Offspring, Elizabeth Callaway

Animal Science Undergraduate Honors Theses

Feral swine were first brought to the United States in the 1500s as a source of food and have been reported as an invasive species since then without an efficient method of population control. Ongoing research indicates that the total cost of the damage this species has caused estimates to around 1.5 billion dollars each year (USDA, 2023). Gossypol is a phenolic compound found in the cotton plant and can be administered in the form of cottonseed meal (CSM). Gossypol has been associated with reduced fertility in various species (Randel et al., 1992). Pregnant sows were fed cottonseed meal to …

A Tale Of Two Asters: Resolving The Plant And Microbial Community Structure Of An Invasive And Native Forb, William Cartelli

Theses, Dissertations and Culminating Projects

Old fields dominated by flowering forbs are frequent targets for ecological restoration, particularly because they are often inhabited by invasive species whose ecological effects remain context dependent and widely debated. While native plants are typically favored in restoration efforts, and invasive species viewed as threats to biodiversity, such classifications may oversimplify ecological function. This study investigates two dominant genera of the Asteraceae family —Centaurea stoebe (L) (non-native) and Solidago spp. (S. rugosa and S. canadensis, both native)—to examine whether biogeographic origin or ecological strategy more strongly influences their impact on above and below ground community structure. Despite their contrasting origins, …

Improving Brain Health: Exercise As A Tool For Enhancing Executive Function And Reducing Stress In Older African Americans, Destiny Ellise Ramos

Theses, Dissertations and Culminating Projects

Older African American (AA) adults face disproportionately higher risk of stress and Alzheimer's Disease and Related Dementias (ADRD) compared to other racial and ethnic groups, yet they remain underrepresented in intervention-based research. Previous research has suggested aerobic exercise may reduce stress and benefit executive functioning, which is among the first cognitive domains to be affected in ADRD; however, no studies to date have directly tested the impact of aerobic vs. non-aerobic exercise in older AAs at high risk for developing ADRD. The current study evaluated the effects of a group-based cardio dance fitness (CDF) exercise intervention versus a strength, flexibility, …

Reevaluating The Role Of Ruppia Maritima: Recruitment Dynamics And Habitat Use By Blue Crabs (Callinectes Sapidus) And Associated Benthic Fauna In A Mid-Atlantic Seagrass Community, Delaney St. Pierre

Theses, Dissertations and Culminating Projects

The value of seagrasses as essential fish habitat is well recognized, but limited data exist on the value of one particular species, Ruppia maritima (widgeon grass), as habitat for fish and invertebrates. During the summer of 2024, I evaluated R. maritima, Zostera marina (eelgrass) and mixed beds to assess their relative value as habitat in Barnegat Bay, New Jersey. Results from throw traps indicated significant monthly differences for pipefish, gobies, blue crabs, grass shrimp, and sand shrimp, driven by active recruitment events. When evaluating habitat type, we found no taxa that were significantly more abundant in Z. marina habitat as …

Neuronal Tol-1 Integrates Microbial And Metabolic Cues To Modulate Feeding And Aversion In C. Elegans, Gursimran Singh Gujral

Theses, Dissertations and Culminating Projects

Toll-like receptors (TLRs) are key mediators of innate immunity, but emerging evidence suggests that they also play critical roles in the functioning of the central nervous system. This thesis explores the function of TOL-1, the Caenorhabditis elegans homolog of mammalian TLRs, in sensory neurobiology and behavioral responses to nutritive food. In particular, carbon dioxide and ethanol are commonly encountered in microbial environments and can signal metabolically active food sources or potential pathogens. Using tol-1 loss-of-function mutants, neuronal rescue lines, and a combination of molecular, tissue imaging, and behavioral assays, we demonstrate that TOL-1 functions in chemosensory neurons to regulate feeding …

Neuro-Immune Regulation Of Feeding Behavior And Alcohol Intoxication In Caenorhabditis Elegans, Kamya Kiranbhai Shah

Theses, Dissertations and Culminating Projects

Alcohol use disorder (AUD) and obesity are major public health concerns, contributing to more than 28 million deaths annually. Despite extensive research, the mechanisms underlying excessive alcohol and food consumption remain incompletely understood. Emerging evidence suggests that neuro-immune crosstalk plays a pivotal role in feeding and alcohol-induced behaviors, with inflammation as a key pathological hallmark. Toll-like receptors (TLRs), traditionally recognized for their role in innate immunity, have recently been implicated in modulating neural responses to ethanol. However, the mechanisms of how TLR signaling influences feeding and alcohol-related behaviors remain largely unknown. To address this gap, we leveraged Caenorhabditis elegans (C. …

Tracking Fall Migration With The Motus Wildlife Tracking System: The Fate Of Window-Struck And Captive-Raised Passerines, Cailin O'Connor

Theses, Dissertations and Culminating Projects

Many species of North American passerines migrate along the Atlantic flyway in the fall to reach winter habitats in the southeastern United States, the Caribbean, and Central and South America. Birds face many perils along their journeys including window strikes, which kill over one billion birds per year in the United States alone. Some birds survive the impact and may continue their migration. These birds may suffer delayed mortality or show aberrant migration due to injuries. This research seeks to understand if window-struck birds that initially survive bird-building collisions survive into the future and, if so, if they migrate effectively. …

Dabigatran Reduced Acute Microgliosis In A Mouse Model With Tbi, Nicholas R. Eltman, Rashmeena Abbasi, Mary C. Kosciuk, Syed Ahmed, Jose L. Pascual, Randel L. Swanson, Nimish K. Acharya

Rowan-Virtua Research Day

Objective:

The study objective was to investigate the acute anti-inflammatory effects of dabigatran in a preclinical mouse controlled cortical impact (CCI) model of severe traumatic brain injury (TBI).

Design

Mice were separated into three groups: controlled cortical impact (CCI) with dabigatran (drug treatment, n=5), CCI with saline (positive control, n=5), and sham CCI without saline or dabigatran (negative control, n=3). Dabigatran (80mg/kg) or saline was administered orally at 2, 10, 18, 26, 34, and 42 hours following experimental CCI in the drug treatment or positive control groups, respectively. Animals in the negative control group received sham CCI only. 48h following …

Effects Of The Non-Stimulant Norepinephrine Reuptake Inhibitor, Atomoxetine, On Cognitive Flexibility In Healthy Adult Long-Evans Rats, Noah A. Ivak, Samantha Walkow, Christopher Knapp, Eleni Papadopoulos, Barry D Waterhouse, Rachel L Navarra

Rowan-Virtua Research Day

Executive function is the control of multiple higher order cognitive processes that include attention, working memory, and cognitive flexibility. Cognitive flexibility is the ability to shift behavioral strategies

in response to changing environmental demands and task complexity. This cognitive modality is often impaired in many neuropsychiatric disorders like attention deficit hyperactivity disorder (ADHD). Deficits in cognitive flexibility are associated with dysregulation of the catecholamines, norepinephrine (NE) and dopamine (DA) within the prefrontal cortex (PFC). Atomoxetine (ATX), a non-stimulant NE reuptake inhibitor, elevates levels of NE and DA in the PFC by inhibiting the norepinephrine transporter (NET). ATX is used to …