Digital Commons Network^™

Coordinated Regulation By Lncrnas Results In Tight Lncrna-Target Couplings, Hua-Sheng Chiu, Sonal Somvanshi, Chung-Te Chang, Eric James De Bony De Lavergne, Zhaowen Wei, Chih-Hung Hsieh, Wim Trypsteen, Kathleen A Scorsone, Ektaben Patel, Tien T Tang, David B Flint, Mohammad Javad Najaf Panah, Hyunjae Ryan Kim, Purva Rathi, Yan-Hwa Wu Lee, Sarah E Woodfield, Sanjeev A Vasudevan, Andras Attila Heczey, M Waleed Gaber, Gabriel O Sawakuchi, Ting-Wen Chen, Pieter Mestdagh, Xuerui Yang, Pavel Sumazin

Faculty, Staff and Student Publications

The determination of long non-coding RNA (lncRNA) function is a major challenge in RNA biology with applications to basic, translational, and medical research. We developed BigHorn to computationally infer lncRNA-DNA interactions that mediate transcription and chromatin-remodeling factor activity. Its accurate inference enabled the identification of lncRNAs that coordinately regulate both the transcriptional and post-transcriptional processing of their targets. These lncRNAs may act as molecular chaperones, regulating the stability and translation of mRNAs they helped transcribe, leading to tightly coupled expression profiles. Our analysis suggests that lncRNAs regulate cancer genes across tumor contexts, thus propagating the effects of non-coding alterations to …

A Lysosomal Surveillance Response To Stress Extends Healthspan, Terytty Yang Li, Arwen W Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J Liu, Rachel N Arey, Kimberly Morales, Raya B Liu, Wenzheng Wang, Ang Zhou, Tong-Jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H Houtkooper, Johan Auwerx

Faculty, Staff and Students Publications

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H+-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive transcriptional response typified by induction of a set of transcripts involved in lysosomal function and proteolysis, which we termed the lysosomal surveillance response (LySR). LySR activation is characterized by boosted lysosomal activity …

Decoding Metastatic Microenvironments Through Single-Cell Omics Reveals New Insights Into Niche Dynamics And Tumor Evolution, Fengshuo Liu, Xiang H-F Zhang

Faculty, Staff and Students Publications

Metastasis is the predominant cause of cancer mortality, primarily driven by complex tumor-host interactions within specialized metastatic niches. Recent advances in single-cell technologies have provided unprecedented insights into metastatic niche formation, evolution and function, including how primary tumors precondition distant organs for metastases and how disseminated tumor cells dynamically interact with host cells to modulate their environments. Integrated single-cell studies across multiple cancer types have also revealed divergent and convergent metastatic adaptation strategies. These findings collectively highlight metastasis as a dynamic, cooperative process shaped by intricate tumor-host interactions, and provide a foundation for novel therapeutic strategies targeting components of the …

Microbial Biosensor For Sensing And Treatment Of Intestinal Inflammation, Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V Douglas, Walter J Chazin, Eric P Skaar, Jeffrey J Tabor, Robert A Britton

Faculty, Staff and Students Publications

Synthetic biology has enabled the development of biosensors to detect intestinal inflammation, yet few target the clinically validated biomarker of intestinal inflammation calprotectin with both diagnostic and therapeutic capabilities. Here, an optimized calprotectin biosensor is presented that leverages a zinc uptake regulator (Zur) controlled promoter coupled with a memory circuit to detect and record intestinal inflammation in vivo. The level of biosensor activation strongly correlates with calprotectin levels in the colon of two independent mouse models of colitis. Coupling of the biosensor with the production of the anti-inflammatory cytokine IL10 allowed for the resolution of chemically induced colitis, demonstrating the …

Inhibition Of The Gsk3Β/Nav16 Complex Suppresses Early-Stage Alzheimer’S Hyperexcitability, Timothy John Baumgartner, Manuel Silva-Pérez, Zahra Haghighijoo, Nolan Michael Dvorak, Aditya Kumar Singh, Nana Aboadwe Goode, Jully Singh, Berenice Gutierrez Grebenkova, Mate Marosi, Jessica Di Re, Leandra Koff, Wissarut Wijitrmektong, Manu Bala, Hanyue Liao, Marijn Lijffijt, Adam Thomas Szafran, Michael James Bolt, Michael A Mancini, Gregory D Cuny, Diana Shu-Lian Chow, Agenor Limon, Jeannie Chin, Fernanda Laezza

Faculty, Staff and Students Publications

Introduction: Network hyperexcitability (NH) is observed in patients with early-stage Alzheimer's disease (AD), emerging decades before cognitive decline. A key molecular determinant of NH is voltage-gated Na+ channel 1.6 (Nav1.6), which mediates action potential firing in CA1 hippocampal neurons. Ameliorating NH through inhibition of the glycogen-synthase kinase 3β (GSK3β/Nav1.6 complex may provide immediate benefits to cognition and memory and slow AD progression.

Methods: Hight-throughput virtual screening and multiple in vitro biological assays were utilized to identify compound 1063. Patch-clamp electrophysiology and electroencephalogram recordings were utilized to functionally assess 1063 in models of AD neuropathology.

Results: Building on previous studies identifying …

Clonal Evolution Of Hematopoietic Stem Cells After Autologous Stem Cell Transplantation, Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Linda Zhang, Jennifer Padilla, Li Zhao, Joanne I Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Satoko Ogata, Sarah Hanache, Hui Yang, Courtney Dinardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Latasha Little, Curtis Gumbs, Robert Z Orlowski, Muzaffar Qazilbash, Kapil Bhalla, Simona Colla, Hagop Kantarjian, Rashmi Kanagal-Shamanna, Carlos Bueso-Ramos, Daisuke Nakada, Gheath Al-Atrash, Jeffery Molldrem, P Andrew Futreal, Elizabeth Shpall, Margaret Goodell, Guillermo Garcia-Manero, Koichi Takahashi

Faculty, Staff and Student Publications

The impact of exogenous stressors, such as cancer chemotherapies, on the genomic integrity and clonal dynamics of normal hematopoiesis is not well defined. We conducted whole-genome sequencing on 1,276 single-cell-derived hematopoietic stem and progenitor cell (HSPC) colonies from ten patients with multiple myeloma treated with chemotherapies and six normal donors. Melphalan treatment significantly increased the mutational burden, producing a distinctive mutation signature, whereas other chemotherapeutic agents had minimal effects. Consequently, the clonal diversity and architecture of post-treatment HSPCs resemble those observed in normal elderly individuals, particularly through the progression of oligoclonal hematopoiesis, thereby suggesting that chemotherapy accelerates clonal aging. Integrated …

Unfolding The Mystery Of Autoimmunity: The Environmental Determinants Of Diabetes In The Young (Teddy) Study, Marian Rewers, Daniel Agardh, Suzanne Bennett Johnson, Ezio Bonifacio, Helena Elding Larsson, Patricia Gesualdo, William Hagopian, Michael J Haller, Heikki Hyöty, Randi Johnson, Richard Mcindoe, Eoin Mckinney, Jessica Melin, Åke Lernmark, Richard E Lloyd, Kristian F Lynch, Jill M Norris, Stephen S Rich, Roswith Roth, Desmond Schatz, Jorma Toppari, Eric Triplett, Kendra Vehik, Suvi M Virtanen, Anette-G Ziegler, Beena Akolkar, Jeffrey P Krischer, Teddy Study Group

Faculty, Staff and Students Publications

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment and prevention and a cure for these conditions. Autoimmunity that leads to type 1 diabetes or celiac disease or thyroid autoimmunity affects 1 in 20 children and adolescents in the U.S. While treatments are available, prevention of these common autoimmune …

Increasing Flora Diversity In Grassland Swards, R J. Haggar, D Jones

IGC Proceedings (1977-2023)

Europe's farmers are being encouraged to take land out of agriculture in order to reduce surplus cereal production. There is therefore, increasing scope for creating new species-rich swards, although guidelines for this purpose are lacking. Several reasons are advanced for encouraging species diver­sity and conservation, including recreational, ethical, education and resource utilisation. As leisure time increases, so public interest in conservation matters increases. Scientifically, there is a need to preserve genetic diversity and to understand the com­plex plant and animal relationship leading to a rich and varied community. This paper describes two experiments aimed at achieving a . highly diverse …

Multiple Of The Intermountain Region, Forest Service, United States Department Of Agriculture, J S. Tixier, A H. Winward

IGC Proceedings (1977-2023)

Initial custodians of the National Forests of the United States were primarily concerned about protecting what were perceived as deteriorating timber stands and watersheds. Con­siderable progress was made in correcting these problems in the first half of this Century. As the population of the United States grew, more people became interested in management of all resources on these public lands. Forest Officers gradually became stewards managing a broad array of lands and resources for which there were often conflicting interests and uses. A primary use of National Forests in the Western United States has been livestock grazing. Here, animals are …

Fringed Sagebrush, Ming Chang Wang

IGC Proceedings (1977-2023)

Fringed sagebruch (Artemisia frigida will) is one of the common plants in inner mongolia plateau. It was recognized as an excellent perennial herbaceous plants accunting for a large proportion in wild vegetation. Fringed sagebruch belongs to composites, Semi-frutex, tomentellate in whole plant, tap root may be 100 cm deep in the soil. Fringed sagebrush distributed to the north of the Yellow River in China, Fareast and Caucasus in USSR, Mongolia and Canada. Fringed sagebruch is an excellent forage for horses, cattle, sheep, goats and Camels. The animals will get gain if fringed sagebruch is fed.

Assessment Of Agronomic Performance Of Large Numbers Of Plant Accessions Using A Computerized Data Management System, D A. Ivory, A Ella, J Nulik, R Salam, M E. Siregar, S Yuhaeni

IGC Proceedings (1977-2023)

A major research effort has been directed to finding suitable forage species for animal production in various regions of Indonesia. The two difficulties common to most preliminary evaluation studies of large numbers of diverse groups of forage plants is in deciding firstly what plant attributes should be assessed and secondly, the methods to be used in the management and analysis of large masses of data. A set of minimum plant attributes has been used for both grasses, herbaceous legumes and tree legumes in experiments at a number of key testing sites in Indonesia. A computerized system of data management from …

Forage Attributes Of The Perennial Groundnut Arachis Pintoi In A Tropical Savanna Environment In Colombia, B Grof

IGC Proceedings (1977-2023)

In the continuing search for superior germplasm of tropical legumes adapted to Oxisol savanna conditions, a study of the perennial wild species of groundnut (peanut), Arachis pintoi, was initiated at Carimagua Research Station on the eastern plains (Llanos Orientales) of Colombia. A pintoiis an agronomically little-known legume pasture species indigenous to South America. Its performance in grazed association with four different Brachiaria spp. was evaluated in terms of dry matter yield and animal weight gain. A. pintoi was successful under conditions of heavy grazing (2.4 animal units/ha) employed on a year-round basis. Total grass and legume dry matter (DM) yields …

The Effect Of Previous Experience Of Animals On Subsequent Preference In A Palatability Grazing Trial, C Lascano, P Hoyos, R Schultze-Kraft, M C. Amexquita

IGC Proceedings (1977-2023)

Previous experience of test animals has been mentioned as a factor which may affect grazing preference of cattle. Palatability trials have usually been conducted without allowing animals to previously graze individual forage species under evaluation. A cafeteria trial was designed to study the effect of previous grazing of individual species in the palatability ranking of six tropical legumes. Results indicated that short-term previous experience of the test animals affected the magnitude of the palatability index of the most palatable legume on the first days of the trial, but did not affect the overall palatability ranking of species. Therefore, it would …

Aeschynomeme - A Legume Genus With Potential For The Australian Tropics, H G. Bishop, B Walker, D H. Ludke, M T. Rutherford

IGC Proceedings (1977-2023)

Aeschynomene spp. have been identified as a promising group of legumes adapted to seasonally waterlogged soils on the central Queensland wet coast. Near Mackay (1470 mm M.A.R.) the legume component of Macroptilium atropurpureum cv. Siratro/Setaria sphacelala var. sericea cv. Kazungula pastures on adequately fertilized solodic soils, did not persist under heavy grazing (2.5 and 2.0 steers/ha), whereas the native legume Aeschynomene indica persisted and gave yields up to 1401 kg/ha. At light stocking rates siratro persisted, whereas frequency and yields of A indica were negligible. After an introduction and evaluation programme, A. americana CPI 58491 was released in 1983 …

Summer Forage Legume Introduction In Louisiana, A M. Thro, C C. Shock

IGC Proceedings (1977-2023)

Climate in Louisiana is influenced by tropical air masses in summer and alternately by tropical and continental air masses in winter. From northwest to southeast, the number of frost-free growing days increases from 230 to 350. Rainfall increase from 1200 mm to 1500 mm and is evenly distributed winter through summer with a generally drier fall. Livestock production is an important economic activity throughout the state. Animal performance declines from July through November in spite of adequate availability of perennial grass forage. A summer-growing forage legume is sought that will persist in perennial grass pastures and provide a more easily …

A Study Of Phenology, Herbage Yield And Crude Protein Content Of Native Ecotypes Of Red Bromegrasses (Bromus Tomentellus Boiss.) Of Iran, B Peymani-Fard

IGC Proceedings (1977-2023)

This research was conducted on ten ecotypes of red bromegrasses of Iran at Homand Range Experiment Station, near Damavand, Iran to asses: (a) the differences in phenological characteristics, (b) to evaluate differences in herbage yield, and (c) determine the crude protein percentage Parameters measured include duration of vegetative, heading, maturity stages, herbage yields, and crude protein. Variation in vegetative growth, heading and seed maturity stages among the ecotypes under study was very small

Therefore, there are no prefences in selection of a specific ecotype from the standpoint of utilization and harvesting time. There was a great fluctuation in annual herbage …

Life Beneath The Tides: Seagrass Meadows In Surigao Del Sur, Philippines, Giselle B. Ramos, Roxan E. Caray

Journal of King Abdulaziz University: Marine Science

Seagrasses are a valuable component of global blue carbon ecosystems yet are also endangered due to natural and man-made pressures. This study assessed the seagrass resources regarding species community structure and diversity using a transect-quadrat design along the intertidal coastlines of selected towns of Surigao del Sur. Of the 19 recorded species in the Philippines, seven common species were observed: Cymodocea rotundata, Enhalus acoroides, Halodule pinifolia, Halodule uninervis, Thalassia hemprichii, Syringodium isoetifolium, and Halophila ovalis. Across study sites, the most evident species are T. hemprichii, C. rotundata, and S. isoetifolium; the existence …

Assessment Of Dominant Shark And Ray Species And Their Size At Brondong And Muncar Ports, East Java, Indonesia, Tri Djoko Lelono, Gatut Bintoro, Arief Setyanto, M. Arief Rahman, Desy Setyoningrum, Naufal Hilda Bahtiar, Hanifa Ramadhani, Tawang Firmansyah, Hasan Syaiful Rizal

Journal of King Abdulaziz University: Marine Science

Shark and ray species are both limited in number and distribution and require time to mature and reproduce, making these species extremely vulnerable to mass exploitation as a resource. Based on the identification results, Muncar Port Banyuwangi had 26 species from 490 ray samples, and Brondong Port Lamongan had 28 species from 1830 ray samples. Fifteen species of rays were found only in Brondong, 17 species of rays were found only in Muncar, and as many as 13 were found in the two sample sites. As for sharks in Muncar, 38 out of 679 species were Brondong samples and 22 …

Innovations In Shipbuilding: A Comprehensive Review Of Material Selection, Corrosion Management, And Environmental Considerations, Oumaima Bouanani, Sara Sandabad, Moulay El Houssine Ech-Chhibat

Journal of King Abdulaziz University: Marine Science

The shipbuilding industry, a cornerstone of global maritime operations, oversees vessel lifecycles from design through commissioning. This article delves into the industry's complex role in facilitating global trade, driving technological advancements, and prioritizing sustainability and safety. The harsh marine environment-marked by salinity, temperature extremes, and mechanical stresses-necessitates resilient and durable vessel structures. Consequently, the careful selection of materials is crucial for ensuring vessel longevity and performance under stringent safety and environmental standards. Recent breakthroughs in shipbuilding materials, including high-strength steel, composites, and lightweight alloys, have transformed the industry. Innovative solutions, such as shape memory alloys and eco-friendly composites, are designed …

Exploring Students’ Perceptions Of Science Laboratory Practices: A Comparative Study Between Rural And Urban Schools, Safrida Dwiningsih, Ina Lestari, Roma Ismi, Sri Wahyu Rahmadina, Masdalena Sinaga, M. Rahmad

Jurnal Pendidikan Sains

This study aims to analyze students' perceptions of the implementation of science laboratory practicums at public middle school 020 Pekanbaru and public middle school 7 Pangkalan Kuras, Riau Province. Using a quantitative survey method, this study involved 75 student respondents. The instrument used was a questionnaire consisting of 26 statements, analyzed descriptively. The results show that students' perceptions of the preparation, implementation, and conclusion stages of the practicum fall into the "good" category, with urban schools having a higher percentage. In conclusion, the implementation of practicums in urban schools is better than in rural schools, bringing attention to the need …

Digital Comic Learning Media (E-Comic) To Increase Student Learning Interest In Reaction Rate Material At High School, Berliana Afsohin Nabila, Achmad Lutfi

Jurnal Pendidikan Sains

This study aims to develop digital comic learning media that is effective in increasing students' interest in learning about reaction rate material, focusing on the media's validity, practicality, and overall effectiveness. This research utilizes the research and development method with the ADDIE model. Research instruments were used, including validity sheets to assess the media's validity, student activity observations, and student response questionnaires to evaluate the media's practicality, as well as student interest questionnaires and learning outcomes to measure the effectiveness of the learning media. The findings show that validity results showed a mode score of 4, indicating a very valid …

The Effort To Improve Students’ Problem-Solving Ability: Physics E-Modules For High School Students, Hidayatullah Hana Putra, Edi Supriana, Nasikhuddin Nasikhuddin, Annisa U. Yana, Suhailee Sohnui

Jurnal Pendidikan Sains

Physics teachers in Indonesia still face obstacles during learning, such as students who are less active and have difficulty in solving physics problems. The physics learning media used are also still not very interesting and are not based on authentic problem solving. Therefore, this study focuses on the development of PBL-based e-modules on work and energy to improve the physics problem-solving abilities of high school students. This research and development used the ADDIE design and was tested on 90 high school students in High School 1 Sumber Pucung Malang in the 2022/2023 academic year. The questionnaire instrument was used in …

Integration Of Mechanism-Driven Computational Modeling And Public Data Resources For Chemical Toxicity Assessment, Elena Chung

Theses and Dissertations

Regulatory toxicology depends primarily on animal testing, which limits throughput, mechanistic interpretability, and applicability to human-relevant endpoints. This dissertation presents computational approaches that integrate publicly available bioactivity data with machine learning to support chemical safety evaluation. Oral carcinogenicity was modeled using curated chemicals from the US Environmental Protection Agency’s Integrated Risk Information System (IRIS) and activity data from over 1,900 PubChem assays. Quantitative structure-activity relationship (QSAR) models trained on statistically prioritized assays demonstrated strong predictive performance and were applied to rank the carcinogenic potential of more than 16,000 compounds. Hepatotoxicity was evaluated using a hybrid modeling approach that combined structural …

Antibiofilm Activity Of Amylases Isolated From The Bacteria Associated With The Soft Coral Sarcophyton Trocheliophorum, Asmaa Marshoud Al Harbi, Mamdoh T Jamal, Sathianeson Satheesh

Journal of King Abdulaziz University: Marine Science

Amylases are one of the important enzymes with tremendous biotechnological applications. In this study, the amylase enzyme producing bacterial strains associated with the soft coral Sarcophyton trocheliophorum was isolated and identified. The amylases were produced in a specific growth medium and the stability was tested under different pH and temperature conditions. The crude amylases were tested for the antibiofilm activity against two biofilm-forming bacterial strains. The amylase enzyme extracted from two bacterial strains (KAU-AS1 and KAU-AS3) showed good activity in the antibiofilm activity assays. The amylases reduced the growth and attachment of the biofilm bacteria. Also, the amylase enzymes degraded …

Lifecycle Of Greater Wax Moth Galleria Mellonella (Lepidoptera: Pyralidae) And Its Control By Natural Products, Tahani A. Alzahrani, Hanan S. Alyahya, Shatha I. Alqurashi, Jazem A. Mahyoub

Journal of King Abdulaziz University: Meteorology, Environment and Arid Land Agriculture

The great wax moth (Galleria mellonella) is a major pest that affects honeybee colonies, causing serious damage to the honeycomb and disrupting beekeeping operations. This paper aims to review the life cycle of this insect and the natural control strategies used to manage its populations. This paper examines the different stages of growth of the great wax moth, including the stages of eggs, larva, pupae, and adults. The life cycle of this insect depends largely on environmental conditions, especially temperature, humidity and food quality, in addition, this paper focuses on natural control strategies, such as the use of plant extracts …

Production And Characterization Of Biodiesel From Malapari Seed Oil (Pongamia Pinnata L.): Evaluation Of Quality Parameters Based On The Indonesian National Standard (Sni) 04-7182-2015, Desi Adriyanti Nina Taebenu, Ni Luh Arpiwi, Ida Ayu Astarini

Makara Journal of Science

This study produced biodiesel from Malapari seed oil (Pongamia pinnata L.) by optimizing the esterification and transesterification processes. The objectives of this study were to determine the sulfuric acid (H₂SO₄) catalyst concentration in the esterification reaction that can reduc the free fatty acid (FFA) content of the seed oil to ≤2%, analyze the oil to methanol molar ratio (i.e.,1:6, 1:9, and 1:12) and KOH concentration (i.e.,2%, 4%, and 6%) that will produce the highest biodiesel yield, and evaluate the quality of the produced biodiesel according to the Indonesian National Standar (SNI) 04-7182-2015. The research was …

Bayesian-Weighted Mendelian Randomization Reveals Sleep Apnea Syndrome Mediates The Bmi-Chronic Pain Link, Wenbao Shi, Jing Luo, Liu Yang, Dalin Chen, Yongqin Zhang, Jun Peng, Kurt Ruetzler, Manyun Sun, Hua Jin

Faculty, Staff and Student Publications

Background: Body mass index (BMI) has a complex association with a variety of chronic pain conditions, which may be influenced by sleep apnea syndrome (SAS). However, the role of SAS within the causal pathway linking BMI to chronic pain remains unconfirmed. This study explored whether and to what extent SAS serves as a mediator between BMI and chronic pain using Bayesian-weighted Mendelian randomization (BWMR) techniques.

Methods: This study utilized genome-wide association study (GWAS) summary data for BMI (N=461,460) and SAS (N=476,853; based on ICD-10 code diagnostic registries) from the IEU OpenGWAS database, along with chronic pain GWAS data (ICD-10 code-based …

Metabolic And Physiological Regulation In C. Elegans: Insights Into Sperm Activation And Peroxisome-Mediated Longevity, Yash Flora

LSU Doctoral Dissertations

Organelle dynamics lie at the heart of cellular signaling and metabolic regulation, orchestrating physiological processes such as reproduction and aging across the lifespan. In this dissertation, I investigate how organelle-based signaling coordinates sperm activation and modulates organismal aging in the nematode Caenorhabditis elegans. I identify SPIN-4, a previously uncharacterized Spinster family transporter, as a key regulator of spermiogenesis. SPIN-4 is strongly expressed in developing sperm, localizes to the plasma membrane, and promotes sperm activation by facilitating the export of sphingosine-1-phosphate (S1P). Loss of spin-4 results in defective pseudopod formation, reduced motility, and compromised fertility, phenotypes that can be rescued …

Vitamin D3 Toxicity-Induced Hypercalcemia In Staphylococcal Arthritis: A Focus On Il-6, Ali Jabbar Abd Al-Hussain Alkawaz, Maryam Sabah Naser, Ali Jalil Obaid, Zakaria M. Al-Ghazaly

Karbala International Journal of Modern Science

Background: Vitamin D3  over-supplementation can induce toxicity through the development of hypercalcemia and may disturb immune modulation. This study examines the relationship between hypercalcemia  resulting from Vitamin D3 Overdose and serum Interleukin-6 (IL-6) levels in patients diagnosed with staphylococcal arthritis.

Methods: Forty male patients (mean age: 31 years; range: 17–45 years) were enrolled from Dec. 2024 to Feb. 2025. Twenty cases of staphylococcal arthritis were compared with twenty healthy male controls. Serum concentrations of Vitamin D3, calcium, IL-6, and other biochemical markers (urea, creatinine, ESR, WBC, and potassium) were analyzed. Staphylococcus aureus was isolated from synovial fluid and confirmed using …

Bite By Bite: How Ungulate Browsing Shapes North America's Forest Future, Darius Hardalau, Vladut Stefanescu, Mindaugas Bakševičius, Michael Manton, Charles Ruffner, Gediminas Brazaitis, Georgeta Ionescu, Ovidiu Ionescu

Aspen Bibliography

Ungulate browsing represents a contemporary issue for forest development, influencing forest regeneration, composition, and management practices across the world, especially in North America. This review synthesizes findings from 101 studies conducted between 1980 and 2025 to examine patterns of herbivory damage through browsing by moose, elk, white-tailed deer, black-tailed deer, and bison. Despite regional variation, high ungulate density consistently emerges as the primary factor driving browsing intensity and ecological and economic impact, leading to decreased social acceptance of coexistence with ungulates. This review highlights the selective suppression of palatable species such as balsam fir, red oak, and white cedar, leading …