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Dual Action Dynamics: Assessing Hypopharyngeal Cancer Cell Survival Using Combination Chemotherapy, Luke Nieman Jul 2025

Dual Action Dynamics: Assessing Hypopharyngeal Cancer Cell Survival Using Combination Chemotherapy, Luke Nieman

Biology Summer Fellows

Targeting glucose metabolism is an attractive strategy for cancer treatment, as cancer cells rely more heavily on glycolysis than oxidative phosphorylation, a phenomenon known as the Warburg Effect (Wang et al 2015). Reversing this metabolic reprogramming can impair cancer cell proliferation. NG52, a small-molecule inhibitor of PGK1, has been shown to effectively reverse the Warburg Effect and reduce cancer cell viability (Wycliffe et al. 2007). Paclitaxel, commonly Taxol, is a chemotherapeutic agent that disrupts mitotic spindle function, causing mitotic arrest and apoptosis (Markman et al 2005). In this study, we aimed to evaluate the individual and combined effects of NG52 …


Patterns And Processes Behind Secretive Marshbird Movement, Abundance, And Distribution Across Southeastern Louisiana, Leah Moran Jul 2025

Patterns And Processes Behind Secretive Marshbird Movement, Abundance, And Distribution Across Southeastern Louisiana, Leah Moran

LSU Doctoral Dissertations

Restoration and conservation of coastal Louisiana hinges on understanding the patterns and processes underlying habitat heterogeneity on the landscape and therefore the species that inhabits this region, including secretive marshbirds. Elusive in nature, this guild of birds has evolved under dynamic hydroperiods, and myriad plant communities present within wetlands. Only recently, however, has research focused on the role of hydrologic dynamics and vegetative structure and distribution on abundance, movement and detection of marshbirds, specifically within southeastern Louisiana. This study aimed to quantify the ecological patterns and processes, particularly hydrologic processes and landscape structure, driving breeding secretive marshbird movement, abundance and …


Twist And Snout: Head And Body Morphologies Determine Feeding Kinematics In Substrate-Biting Fishes, Tal Perevolotsky, Jacob M. Brotman-Krass, Yarden Ratner, Yael Avigad, Adam P. Summers, Cassandra M. Donatelli, Roi Holzman Jul 2025

Twist And Snout: Head And Body Morphologies Determine Feeding Kinematics In Substrate-Biting Fishes, Tal Perevolotsky, Jacob M. Brotman-Krass, Yarden Ratner, Yael Avigad, Adam P. Summers, Cassandra M. Donatelli, Roi Holzman

Engineering Faculty Articles and Research

Synopsis

Across teleosts, feeding by biting substrate-attached prey has evolved multiple times and is associated with convergent morphologies that include a deep body and an elongated, tapered head. However, the functional role of these morphologies in substrate-biting fish is not established. Here, we tested the hypothesis that these morphologies function as control surfaces that affect feeding kinematics during biting. To test this hypothesis, we used simplified physical models of substrate-biting reef fish and examined the role of head, body, and fin morphology in determining feeding kinematics that facilitate the removal of substrate-attached prey. Models simulated the swift lateral movement of …


Human Ipsc-Based Breast Cancer Model Identifies S100p-Dependent Cancer Stemness Induced By Brca1 Mutation, Jingxin Liu, Cai Zhao, Jiahao Chen, Pengguihang Zeng, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo, Dong-Feng Huang, Jin Bai, Junjun Ding Jul 2025

Human Ipsc-Based Breast Cancer Model Identifies S100p-Dependent Cancer Stemness Induced By Brca1 Mutation, Jingxin Liu, Cai Zhao, Jiahao Chen, Pengguihang Zeng, Qingjian Li, Ranran Dai, Xingqiang Lai, Wenqian Song, Jianing Chen, Xixi Zhu, Xinyi Liu, Jun Sun, Jia Wang, Peihang Fang, Tengfei Wang, Wenjie Chen, Diana Guallar, Nan Cao, Jianli Zhao, Shicheng Su, Andy Peng Xiang, Yi Arial Zeng, Jie Li, Junchao Cai, Dung-Fang Lee, Jinxin Bei, Yongliang Huo, Hai Hu, Shengbao Suo, Dong-Feng Huang, Jin Bai, Junjun Ding

Faculty, Staff and Student Publications

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline


Anatomical And Palynological Studies On Turkish Primula Taxa (Primulaceae) And Their Taxonomic And Phylogenetic Significance, Deni̇z Ulukuş, Esengül Özkaymakoğlu, Rebecca Stubbs, Hüseyi̇n Baykal, Kami̇l Coşkunçelebi̇, Osman Tugay, Barbara Keller, Elena Conti, Ferhat Celep Jul 2025

Anatomical And Palynological Studies On Turkish Primula Taxa (Primulaceae) And Their Taxonomic And Phylogenetic Significance, Deni̇z Ulukuş, Esengül Özkaymakoğlu, Rebecca Stubbs, Hüseyi̇n Baykal, Kami̇l Coşkunçelebi̇, Osman Tugay, Barbara Keller, Elena Conti, Ferhat Celep

Turkish Journal of Botany

Anatomical (scape, pedicel, leaf lamina, and leaf midrib) and pollen morphological features of 11 taxa belonging to the genus Primula subgen. Primula (P. vulgaris subsp. vulgaris, P. vulgaris subsp. rubra, and P.megaseifolia, P. meyeri,P. elatior subsp. pallasii, P. pseudoelatior, P. veris subsp. columnae, P. veris subsp. macrocalyx) and subgen. Aleurita (P. longipes, P. algida and P. auriculata) were examined using light and scanning electron microscopy to shed light on the existing taxonomic and phylogenetic relationships. The anatomical and palynological features of the majority of the taxa studied were revealed for the first time in this study. In anatomical studies, the …


Antibacterial Potential Of Tapanuli Orangutan (Pongo Tapanuliensis) Food In Batang Toru Forest Against Escherichia Coli And Salmonella Typhi, Herna Febrianty Sianipar, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah Jul 2025

Antibacterial Potential Of Tapanuli Orangutan (Pongo Tapanuliensis) Food In Batang Toru Forest Against Escherichia Coli And Salmonella Typhi, Herna Febrianty Sianipar, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah

Karbala International Journal of Modern Science

Diarrhea is a common disease affecting orangutans, primarily caused by Escherichia coli and Salmonella typhi bacteria. To treat this disease, antibacterial food sources are essential as therapeutic agents for orangutans. The fruits consumed by Tapanuli orangutans include Campnosperma auriculatum, Agathis borneensis, Artocarpus heterophyllus, Castanopsis argantea, and Aglaia tomentosa. This study aims to examine the amino acid and phytochemical components with potential antibacterial properties in these five fruit species and their inhibitory effects on E. coli and S. typhi growth through cell lysis, observed using a Scanning Electron Microscope (SEM). The samples were tested for amino acids, phytochemicals, vitamin C content, …


New Paradigms In E. Coli Hemolysin Function And Pathogenesis, Hunter Winston Kuhn Jul 2025

New Paradigms In E. Coli Hemolysin Function And Pathogenesis, Hunter Winston Kuhn

Arts & Sciences Graduate Student Theses and Dissertations

Bacterial pore-forming toxins are potent secreted protein effectors that disrupt cellular ion homeostasis by integrating into the plasma membrane. Among them, the RTX toxin alphahemolysin (HlyA) from uropathogenic Escherichia coli (UPEC) has been extensively studied for its hemolytic activity, broad cell tropism, and role in virulence. HlyA was identified as the first type 1 secreted substrate, with β2 integrin CD18/LFA-1 proposed as its receptor. However, its diverse mechanisms of cellular toxicity and impact on outcomes of urinary tract infection (UTI) have remained incompletely defined. During pyelonephritis, renal epithelial cells are at the front line of infection, directly contacting ascending UPEC …


Environmental, Social, And Molecular Regulation Of Foraging Behavior In The Formosan Subterranean Termite, Arjun Khadka Jul 2025

Environmental, Social, And Molecular Regulation Of Foraging Behavior In The Formosan Subterranean Termite, Arjun Khadka

LSU Doctoral Dissertations

Foraging is a critical activity in social insects, essential for resource acquisition and colony sustenance. In termites, this behavior is shaped by environmental, social, and genetic factors, yet the underlying regulatory mechanisms remain poorly understood. In this study, we examined how environmental food and moisture availability, and the age of termites affected foraging activities, along with the molecular regulation of foraging in the Formosan subterranean termite, Coptotermes formosanus, using a combination of behavioral assays, transcriptomics, and molecular biology approaches. First, we demonstrate that food and moisture deprivation (FMD) significantly affects foraging, with termites under deprivation conditions exhibiting increased foraging …


Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter Jul 2025

Public Support For Puma Reintroduction In The Eastern United States, L. Mark Elbroch, Jazmin J. Murphy, Shelby C. Carlson, John A. Vucetich, Richard E.W. Berl, Lexi Galiardi, Shelby Perry, Tom Butler, Neil Carter, Joseph W. Hinton, Axel Moehrenschlager, Emily Carrollo, Rana Bayrakcismith, Jeremy T. Bruskotter

Michigan Tech Publications

Pumas (Puma concolor) are among the species identified as having the potential to enhance ecosystem function. Previous research highlights sufficient ecological habitat to support pumas in the eastern United States; however, their reintroduction requires social and institutional support as well. To this end, we conducted research to assess attitudes about puma reintroduction among key constituencies like hunters, rural residents, and young people. We sampled 2756 respondents across seven states (Massachusetts, Maine, New Hampshire, New York, Pennsylvania, Vermont, and West Virginia). Ratios of strong support (for puma reintroduction) to strong opposition across states ranged from 4:1 to 13:1, and support outweighed …


Multiple Stressors Effects On The Physiological Performance Of Mytilus Trossulus, M. Christina Vasquez, Alana J. Borer, Claribel Y. Alcantar, Osiris Guinea Zepeda, Camya A. Brazil, Colin Carr, Emma Guerrini Romano, Alexander J. Provenzano, Min Jeon Roh Jul 2025

Multiple Stressors Effects On The Physiological Performance Of Mytilus Trossulus, M. Christina Vasquez, Alana J. Borer, Claribel Y. Alcantar, Osiris Guinea Zepeda, Camya A. Brazil, Colin Carr, Emma Guerrini Romano, Alexander J. Provenzano, Min Jeon Roh

Biology Faculty Works

Mytilus galloprovincialis and M. trossulus co-occur and hybridize along set biogeographical ranges of temperature and salinity along the Pacific coast, USA. However, the role of physiological traits in mussel distribution remains poorly understood. We investigated metabolic rate, antioxidant activity (superoxide dismutase, catalase), oxidative damage (malondialdehyde content, MDA), and clearance rate of M. trossulus under multiple stressors: 7 days of hyposalinity (20, 28, 34 ppt), followed by an acute heat shock (17, 20, 25 ◦C). We found a significant effect of temperature on metabolic rate, an interaction effect on antioxidant activity, and MDA, and independent temperature and salinity effects on clearance …


Sbv_Dps: A Stacking-Bagging-Voting Nested Ensemble Based Diabetes Prediction System Using K-Fold Cross Validation, Sourabh Shastri, Sachin Kumar, Paramjit Kour, Vibhakar Mansotra Jul 2025

Sbv_Dps: A Stacking-Bagging-Voting Nested Ensemble Based Diabetes Prediction System Using K-Fold Cross Validation, Sourabh Shastri, Sachin Kumar, Paramjit Kour, Vibhakar Mansotra

Mansoura Engineering Journal

With the advancement of machine learning techniques, the introduction of the most accurate model has become a necessity. In real-world scenarios, every model has some constraints and assimilates errors, so their performance is not always highly efficient; this sparked the development of ensemble learning. The ensemble approach aims to consolidate the strengths of existing approaches and minimize their weaknesses or decision-making risks. The proposed diabetes prediction system encases a resampling filter, applied to balance the dataset and model builder method, i.e., without the SBV ensemble and with the SBV ensemble method. The model is initially built without using the SBV …


The Histone H3 Lysine 36 Demethylase Kdm2a/Fbxl11 Controls Polycomb-Mediated Gene Repression And Germ Cell Development In Male Mice, Michael T Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A Komarov, Hélène Royo, Alexia Rohmer, Sunwoo Chun, Ching-Yeu Liang, Hubertus Kohler, Taiping Chen, Xiaohong Mao, Mark A Labow, Reginald A Valdez, Michael B Stadler, Dirk G De Rooij, Paola Capodieci, John Tallarico, Antoine H F M Peters, Thomas B Nicholson Jul 2025

The Histone H3 Lysine 36 Demethylase Kdm2a/Fbxl11 Controls Polycomb-Mediated Gene Repression And Germ Cell Development In Male Mice, Michael T Bocker, Grigorios Fanourgakis, Kristie Wetzel, Pavel A Komarov, Hélène Royo, Alexia Rohmer, Sunwoo Chun, Ching-Yeu Liang, Hubertus Kohler, Taiping Chen, Xiaohong Mao, Mark A Labow, Reginald A Valdez, Michael B Stadler, Dirk G De Rooij, Paola Capodieci, John Tallarico, Antoine H F M Peters, Thomas B Nicholson

Faculty, Staff and Student Publications

KDM2A/FBXL11 is a Jumonji-domain containing lysine demethylase catalyzing the removal of mono- and di-methyl modifications of histone H3 lysine 36 (H3K36me1/2). While Kdm2a is required for mouse embryogenesis, its role in adult physiology has been largely unexplored. Using conditional deletion approaches, we demonstrate that Kdm2a deficiency leads to testicular atrophy and male infertility. Although spermatogonial stem cells remain unaffected, proliferating and differentiating spermatogonia exhibit delayed cell cycle progression and apoptosis. RNA-sequencing of purified spermatogonia and spermatocytes reveals Kdm2a-dependent repression of over 750 genes during spermatogonial differentiation. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) demonstrates increased H3K36me2 levels at CpG-rich gene promoters …


The Microtubule-Severing Enzyme Spastin Regulates Spindle Dynamics To Promote Chromosome Segregation In Trypanosoma Brucei, Thiago Souza Onofre, Qing Zhou, Ziyin Li Jul 2025

The Microtubule-Severing Enzyme Spastin Regulates Spindle Dynamics To Promote Chromosome Segregation In Trypanosoma Brucei, Thiago Souza Onofre, Qing Zhou, Ziyin Li

Faculty, Staff and Student Publications

Microtubule-severing enzymes play essential roles in diverse cellular processes, including mitosis and cytokinesis, by modulating microtubule dynamics. In the early branching Trypanosoma brucei, microtubule-severing enzymes are involved in cytokinesis and flagellum length control, but none of them have been found to regulate mitosis. Here we report the characterization of the microtubule-severing enzyme spastin in the procyclic form of T. brucei. We demonstrate that spastin severs microtubule in vitro and overexpression of spastin disrupts spindle microtubules in vivo in trypanosomes, leading to defective chromosome segregation. Knockdown of spastin impairs spindle integrity and disrupts chromosome alignment and segregation. We further show that …


Effects Of Plasma-Activated Water On Wheat: Germination And Seedling Development, Wafaa Abdulrazzaq Abdullah, Hadeel O. Ismael, Duaa A. Uamran, Hammad R. Humud Jul 2025

Effects Of Plasma-Activated Water On Wheat: Germination And Seedling Development, Wafaa Abdulrazzaq Abdullah, Hadeel O. Ismael, Duaa A. Uamran, Hammad R. Humud

Karbala International Journal of Modern Science

The food sector must contend with issues such as pathogen resistance to some of the available chemical agents, environmental pollution, and climate change to provide healthy food for livestock and people. The application of atmospheric pressure plasma jets (APPJs) is one potential solution for such problems. Plasma is appropriate for effective surface decontamination regarding food products and seeds, surface decontamination, and achieving improved agricultural production yields. The impact of plasma-activated water (PAW) produced by plasma jet discharge (PJD) system on in vitro-cultivated wheat seeds is examined in this work. For this aim, a plasma jet system was constructed with a …


Greenhouse Evaluation Of Great Plains Native Grasses And Forbs Tolerance To Postemergence Herbicides Used For Roadside Weed Control, Rachel C. Woody-Pumford, Matthew B. Bertucci, Mike D. Richardson, Dirk Philipp, Hannah E. Wright-Smith Jul 2025

Greenhouse Evaluation Of Great Plains Native Grasses And Forbs Tolerance To Postemergence Herbicides Used For Roadside Weed Control, Rachel C. Woody-Pumford, Matthew B. Bertucci, Mike D. Richardson, Dirk Philipp, Hannah E. Wright-Smith

Horticulture Faculty Publications and Presentations

To combat the decline in North American grasslands and prairies, innovative strategies to establish new native grass and forb plantings must be considered. Integrated vegetation management entails the use of many practices to cultivate desirable vegetation along roadsides, including mowing, applying herbicides, burning, and replanting. Currently, only a limited selection of postemergence herbicides are available to improve native plant establishment along roadsides. A greenhouse herbicide screen that included four postemergence herbicides registered for use on Conservation Reserve Program (CRP) acres and rights-of-way was conducted to test their safety for use on four native grasses (big bluestem, buffalograss, sideoats grama, and …


An Alternative Neural Basis Underlying Leptin Resistance, Hongli Li, Cunjin Su, Yuanzhong Xu, Mette Q Ludwig, Jon Davis, Qingchun Tong Jul 2025

An Alternative Neural Basis Underlying Leptin Resistance, Hongli Li, Cunjin Su, Yuanzhong Xu, Mette Q Ludwig, Jon Davis, Qingchun Tong

Faculty, Staff and Student Publications

Overconsumption of a palatable Western diet, a condition linked to central leptin resistance, contributes extensively to the current obesity epidemic. In this context, intensive efforts have focused on detailing the molecular mechanisms underlying leptin resistance. Here, we demonstrate that chronic inhibition of hypothalamic arcuate GABAergic neurons (ArcGABA) effectively reduced diet-induced obesity (DIO). Interestingly, palatable food exposure increased the activity level of ArcGABA neurons, which do not express the leptin receptor (non-LepR neurons; nonresponsive to leptin). Chronic activation of ArcGABA non-LepR neurons led to massive obesity, which was associated with normal leptin-induced pSTAT3 signaling but phenotypic leptin resistance; i.e., high leptin …


Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xli. Pandinops Sahil Sp. N. From Somaliland (Scorpionidae), František Kovařík Jul 2025

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xli. Pandinops Sahil Sp. N. From Somaliland (Scorpionidae), František Kovařík

Euscorpius

Pandinops sahil sp. n. from Somaliland is described and compared with other species of the genus, fully complemented with color photos of specimens of both sexes of the new species, as well as of their habitat. Pandinops bambii Rossi, 2017 is synonymyzed with Pandinops turieli Kovařík, 2016, syn. n. A key for the species of Pandinops and a map of the distribution of the genus are provided.


Ethical Implications Of Being A Holobiont, Scott F. Gilbert Jul 2025

Ethical Implications Of Being A Holobiont, Scott F. Gilbert

Biology Faculty Works

Developmental plasticity and holobiont theory have undermined the normative concepts of biological individuality. However, such traditional ideas of biological individuality have helped define and support Western ethical views into the 21st century. Guided by some of the ethical formulae of Simone Weil, Hans Jonas, and Alastair MacIntyre, this essay attempts to outline some possible trajectories for an ethics that is bounded by these new biological paradigms of environmental agency. Specifically, the ecological developmental biology concepts of plasticity and holobiont theory permit the “ethics of attention” to focus on the partnerships of living beings. Highlighting environmentally integrated life cycles and their …


Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xl. Barbaracurus Lowei Sp. N. From Ethiopia (Buthidae), František Kovařík, Hassan Sh A. Elmi Jul 2025

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xl. Barbaracurus Lowei Sp. N. From Ethiopia (Buthidae), František Kovařík, Hassan Sh A. Elmi

Euscorpius

Barbaracurus lowei sp. n. from Ethiopia is described and compared with other species of the genus, fully complemented with color photos of specimens of both sexes of the new species, as well as of their habitat. Included is a key for Barbaracurus and a map of the distribution of the genus in the Arabian Peninsula and the Horn of Africa.


Mouse Metastable Epialleles Are Extremely Rare, Chathura J Gunasekara, Uditha Maduranga, Taylor Zhang, Jonathan N Wells, Maria S Baker, Eleonora Laritsky, Yumei Li, Cristian Coarfa, Yi Zhu, Robert A Waterland Jul 2025

Mouse Metastable Epialleles Are Extremely Rare, Chathura J Gunasekara, Uditha Maduranga, Taylor Zhang, Jonathan N Wells, Maria S Baker, Eleonora Laritsky, Yumei Li, Cristian Coarfa, Yi Zhu, Robert A Waterland

Faculty, Staff and Students Publications

Metastable epialleles (MEs) are genomic loci at which epigenetic marks are established stochastically during early embryonic development and maintained during subsequent differentiation and throughout life, leading to stable epigenetic and phenotypic variation among genetically identical individuals. Although MEs were first described in mice over 20 years ago, the extent of epigenetic metastability in the mouse genome remains unknown. We present the first unbiased genome-wide screen for MEs in mice. Using deep whole-genome bisulfite sequencing across tissues derived from the three embryonic germ layers in isogenic C57BL/6J mice, we identified only 29 MEs, precisely localizing them and documenting their rarity. Consistent …


Novel Tools And Datamining Techniques To Visualize And Interpret Historical Sugarcane Datasets, Zachary A. Taylor Jul 2025

Novel Tools And Datamining Techniques To Visualize And Interpret Historical Sugarcane Datasets, Zachary A. Taylor

LSU Master's Theses

Heritable genetic variation is an essential raw ingredient of variety development programs. This variation is acted upon via selection by identifying elite progeny that can be utilized agronomically or exploited as parents. Sugarcane breeders are tasked with creating optimal genetic variation through crossing. Prior knowledge of pedigree and parental performance allows breeders to discern which crosses to prioritize, since the time to make crossing decisions and the space to evaluate tens and thousands of progenies are both limited resources in sugarcane variety development programs. In this project, we have updated and validated the U.S. sugarcane pedigree …


Granulocyte-Colony Stimulating Factor Effects On The Mesolimbic Dopamine Circuitry And Adaptations With Chronic Ethanol Exposure, Rachel Ji-Hyae Campbell Jul 2025

Granulocyte-Colony Stimulating Factor Effects On The Mesolimbic Dopamine Circuitry And Adaptations With Chronic Ethanol Exposure, Rachel Ji-Hyae Campbell

Theses and Dissertations

The mesolimbic dopamine (DA) system contributes to reward and reinforcement learning for ethanol (EtOH). The nucleus accumbens (NAc) receives DA input from the ventral tegmental area (VTA) encoding rewarding information. Acute EtOH increases NAc DA levels, and this DA response is attenuated with chronic EtOH exposure. Furthermore, chronic EtOH results in reduced DA release, increased DA clearance and presynaptic D2-type auto-receptor sensitization. Further research into EtOH-induced neural adaptations that modulate NAc DA release is explored herein, including changes in cholinergic interneurons (CIN), which are known regulators of DA transmission. One potential class of regulators are immune related cytokines, that can …


Truncated Ntrk2 Is Induced In Cap1 Endothelial Cells During Mouse Lung Injury-Repair, Celine Shuet Lin Kong, Mitheera V, Jezreel Pantaleón-García, Scott E Evans, Jichao Chen Jul 2025

Truncated Ntrk2 Is Induced In Cap1 Endothelial Cells During Mouse Lung Injury-Repair, Celine Shuet Lin Kong, Mitheera V, Jezreel Pantaleón-García, Scott E Evans, Jichao Chen

Faculty, Staff and Student Publications

Pulmonary capillary endothelial cells (ECs) consist of two populations, CAP1 and CAP2; how each population reacts to diverse tissue injury is incompletely understood. Using single-cell multiome and mouse genetics, we characterize the induction and function of a truncated isoform of Ntrk2, Ntrk2-T1, in multiple lung injury models. Upon Sendai parainfluenza infection, Ntrk2-T1 is broadly induced in CAP1s after the initial interferon response, associated with increased intronic chromatin accessibility, and persists for weeks. Ntrk2-T1 ECs arise from CAP1s but not CAP2s-traced by


Agent-Based Model Outputs Regarding Error Associated With Drone-Based Animal Surveys, Emma Schultz, Natasha Ellison-Neary, Landon R. Jones, Kristine O. Evans, Raymond B. Iglay Jul 2025

Agent-Based Model Outputs Regarding Error Associated With Drone-Based Animal Surveys, Emma Schultz, Natasha Ellison-Neary, Landon R. Jones, Kristine O. Evans, Raymond B. Iglay

Research Data

Count results from different scenarios of an agent-based model simulating various drone flight patterns across a survey area with differing animal distributions (clumped, random, uniform). Each Excel worksheet contains count results from surveys with specific numbers of animals (n = 4, 9, 25, 49, 100) programmed within the agent-based model survey area.


First National Study On Genomic Profiling Of Escherichia Coli In United Arab Emirates (Uae) Aquatic Environments Shows Diverse Quinolone And Cephalosporin Resistance, A. Papadopoulou, C. A. Moubareck, D. Ryder, A. L. Powell, M. Stone, A. W. Joseph, M. A. Khan, E. Light, D. W. Verner-Jeffreys, J. H. Stahl, W. J.F. Le Quesne Jul 2025

First National Study On Genomic Profiling Of Escherichia Coli In United Arab Emirates (Uae) Aquatic Environments Shows Diverse Quinolone And Cephalosporin Resistance, A. Papadopoulou, C. A. Moubareck, D. Ryder, A. L. Powell, M. Stone, A. W. Joseph, M. A. Khan, E. Light, D. W. Verner-Jeffreys, J. H. Stahl, W. J.F. Le Quesne

All Works

Antimicrobial resistance (AMR) is a serious threat to human, animal and plant health, and over recent years the role of the aquatic environment as a hotspot and dissemination route for resistant bacteria has been increasingly recognised. The United Arab Emirates (UAE) has identified AMR as a critical area of concern; however, limited studies have been conducted regarding the presence of AMR in aquatic environments in the region. This study addresses this gap by conducting a national surveillance to better understand the prevalence of aquatic AMR. We investigated the phenotypic and genotypic resistances in Escherichia coli (E. coli) isolates (n= 256) …


Efficacy Of A Novel Bcl-Xl Degrader, Dt2216, In Preclinical Models Of Jak2-Mutated Post-Mpn Aml, Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J Mead, Raajit K Rampal, Jeffrey W Tyner, Hussein A Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva Jul 2025

Efficacy Of A Novel Bcl-Xl Degrader, Dt2216, In Preclinical Models Of Jak2-Mutated Post-Mpn Aml, Zhe Wang, Anna Skwarska, Gowri Poigaialwar, Sovira Chaudhry, Alba Rodriguez-Meira, Pinpin Sui, Emmanuel Olivier, Yannan Jia, Varun Gupta, Warren Fiskus, Cassandra L Ramage, Guangrong Zheng, Alexandra Schurer, Kira Gritsman, Eirini P Papapetrou, Kapil Bhalla, Daohong Zhou, Adam J Mead, Raajit K Rampal, Jeffrey W Tyner, Hussein A Abbas, Naveen Pemmaraju, Qi Zhang Tatarata, Marina Konopleva

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) that evolves from myeloproliferative neoplasm (MPN) is known as post-MPN AML. Current treatments do not significantly extend survival beyond 12 months. B-cell lymphoma-extra large (BCL-xL) has been found to be overexpressed in leucocytes from patients with MPN, making it a potential therapeutic target. We investigated the role of BCL-xL in post-MPN AML and tested the efficacy of DT2216, a platelet-sparing BCL-xL proteolysis-targeting chimera, in preclinical models of post-MPN AML. We found that BCL2L1, the gene encoding BCL-xL, is expressed at higher levels in patients with post-MPN AML than in those with de novo AML. Single-cell multiomics …


Comparative Mitogenomics Of Clitellata Reveals Mitogenome Organization Can Affect The Mode Of Phylogeny, Deni̇z Mercan, Austin Horenkamp, Merve Nur Aydemi̇r, Habeş Bi̇lal Aydemi̇r, Kurt Neubig, Nai̇me Arslan, Frank E. Anderson Jul 2025

Comparative Mitogenomics Of Clitellata Reveals Mitogenome Organization Can Affect The Mode Of Phylogeny, Deni̇z Mercan, Austin Horenkamp, Merve Nur Aydemi̇r, Habeş Bi̇lal Aydemi̇r, Kurt Neubig, Nai̇me Arslan, Frank E. Anderson

Turkish Journal of Zoology

Clitellata is a major clade of Annelida that includes almost all freshwater and terrestrial annelids as well as many marine species. Aquatic oligochaetes include the union of the two multispecies families: Naididae and Tubificidae. There has been much debate regarding the phylogeny and classification of the cosmopolitan and diverse Naididae. In this study, the total mitogenome sequences of Potamothrix hammoniensis (Naididae: Tubificinae), Stylaria fossularis, Stylaria lacustris, Chaetogaster diaphanus, Chaetogaster diaphanus sp. B, and Slavina appendiculata (Naididae: Naidinae) were sequenced and characterized and can be accessed from NCBI under accession numbers OQ654101, PP909790, PP909791, PP909792, PP909793, and PP893275, respectively. For comparative …


Equine Pituitary Pars Intermedia Dysfunction (Equine Cushing's Syndrome), Cheyanne Eaton, Karl Hoopes Jul 2025

Equine Pituitary Pars Intermedia Dysfunction (Equine Cushing's Syndrome), Cheyanne Eaton, Karl Hoopes

All Current Publications

Pituitary pars intermedia dysfunction (PPID), also known as equine Cushing’s disease, is an endocrine disorder that affects a horse’s pituitary gland. Involving a veterinarian early in the diagnosis and treatment of PPID will greatly enhance the horse’s welfare and longevity. A veterinarian diagnoses PPID by observing symptoms and testing blood. Treatments for this disease include medicinal intervention and dietary changes.


Spatiotemporal Responses To A Rural Highway By Four Mammal Species, Caitlin K. Brett, Anna Rose Mehner, John H. Young Jr., Sarah E. Lehnen, Richard J. Kline Jul 2025

Spatiotemporal Responses To A Rural Highway By Four Mammal Species, Caitlin K. Brett, Anna Rose Mehner, John H. Young Jr., Sarah E. Lehnen, Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

Roads can negatively impact the wildlife communities they transect. Road mortalities from wildlife-vehicle collisions are one direct effect, but roads may also indirectly affect wildlife behavior, movement, or local distribution. Quantifying the spatial extent of these road-effects is important for understanding how roads indirectly affect species of concern, identifying potential sources of disturbance, and for estimating the effectiveness of road mitigation structures. Farm-to-Market Road (FM)106, which transects part of the Laguna Atascosa National Wildlife Refuge in Cameron County, Texas, has been identified as a potential source of wildlife road mortalities, particularly for one of the two remaining breeding populations of …


Synthesis Of Cancrinite Zeolite From Toraja Natural Bentonite For Heavy Metal Removal From Wastewater, Yuli Astuti, Paulina Taba, Siti Fauziah, Syarifuddin Liong, Yusafir Hala, Nur Umriani Permatasari, Satria Putra Jaya Negara, Fadliah Fadliah Jul 2025

Synthesis Of Cancrinite Zeolite From Toraja Natural Bentonite For Heavy Metal Removal From Wastewater, Yuli Astuti, Paulina Taba, Siti Fauziah, Syarifuddin Liong, Yusafir Hala, Nur Umriani Permatasari, Satria Putra Jaya Negara, Fadliah Fadliah

Karbala International Journal of Modern Science

This study explores the production of cancrinite (CAN) zeolite from bentonite found in Toraja (a place in South Sulawesi Province, Indonesia) and its effectiveness in removing Pb2+ and Fe3+ ions from wastewater. The synthesis was carried out using a hydrothermal method with varying NaOH concentrations, where a single phase of zeolite was formed at 5 M, as confirmed through XRD analysis. FTIR results showed the characteristics of CAN zeolite with typical absorption peaks at 676, 622, and 565 cm-1, as well as the presence of carbonate groups (CO₃2-) at 1300-1400 cm-1. SEM …