Digital Commons Network^™

Predation Of Aegaeobuthus Nigrocinctus (Ehrenberg, 1828) (Scorpiones: Buthidae) By A Middle East Black Tarantula, Chaetopelma Olivaceum (C. L. Koch, 1841) (Araneae: Theraphosidae) In Lebanon, Rami Khashab

Euscorpius

I report the first documented case of the buthid scorpion Aegaeobuthus nigrocinctus (Ehrenberg, 1828) serving as prey for the tarantula Chaetopelma olivaceum (C. L. Koch, 1841) in Lebanon. The observation was made during a nocturnal survey in the Mount Lebanon region. The case contributes to the limited records of tarantula predation on scorpions and underscores the role of prey-predator size asymmetry in facilitating high-risk predation among arachnids.

Targeting Aldh16a1 Mediated Thioredoxin Lysosomal Degradation To Enhance Ferroptosis Susceptibility In Smarca4-Deficient Nsclc, Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan

Faculty, Staff and Student Publications

Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN's oxidoreductase function by occluding its active site. We also show that …

Inhibition Of Mcl-1 And Mek Overcomes Mek Inhibitor Resistance In Triple-Negative And Inflammatory Breast Cancers, Mohd Mughees, Moises Tacam, Alex W Tan, Mary Kathryn Pitner, Lakesla R Iles, Xiaoding Hu, Emilly S Villodre, Bisrat G Debeb, Takahiro Kogawa, Bora Lim, Rachel M Layman, Wendy A Woodward, Naoto T Ueno, Debu Tripathy, Savitri Krishnamurthy, Yuan Qi, Lajos Pusztai, Jian Wang, Varsha Gandhi, Geoffrey Bartholomeusz, Chandra Bartholomeusz

Faculty, Staff and Student Publications

The MAPK pathway can drive resistance in highly aggressive breast cancers. Our previous work showed that the MEK inhibitor (MEKi) AZD6244 (selumetinib) prevented lung metastasis in a breast cancer xenograft model. In clinical studies, MEKis as single agents have had only modest activity against solid tumors due to the onset of resistance. Using synthetic lethality siRNA screening, we identified myeloid cell leukemia-1 (MCL-1) as a potential contributor to AZD6244 resistance. We hypothesized that MCL-1 promotes MEKi resistance in highly aggressive breast cancers and that MCL-1 inhibition overcomes AZD6244 resistance. We established two AZD6244-resistant cell lines: MDA-MB-231-R (triple-negative breast cancer) and …

Efficacy Of Atr Kinase Inhibitor Elimusertib Monotherapy Or Combination In Tumors With Dna Damage Response Pathway And Other Genomic Alterations, Kaushik Varadarajan, Christian X Cruz Pico, Kurt W Evans, Maria Gabriela Raso, Yasmeen Qamar Rizvi, Xiaofeng Zheng, Dhruv Chachad, Timothy P Diperi, Bailiang Wang, Stephen M Scott, Ming Zhao, Argun Akcakanat, Antje M Wengner, Timothy A Yap, Funda Meric-Bernstam

Faculty, Staff and Student Publications

The ataxia telangiectasia and RAD3-related (ATR) kinase functions with ataxia telangiectasia-mutated (ATM) kinase as a modulator of DNA damage response (DDR). We assessed the antitumor effects of the ATR inhibitor elimusertib (BAY-1895344) in patient-derived xenograft (PDX) models with DDR alterations. Antitumor activity was assessed by change in tumor volume (TV) from baseline. Responses were categorized as follows: partial response (PR), ≥30% decrease in TV; ≥20% increase in TV, progressive disease; and non-PR/progressive disease, stable disease (SD). Event-free survival was defined as time for tumor doubling (EFS-2). Of 21 PDX models tested, 11 had significant prolongation of EFS-2 with elimusertib monotherapy. …

A Complicated History Of Mitogenome Introgression Among Luxilus Species (Teleostei, Family Leuciscidae) In The Ozark Highlands, David D. Duvernell, Carson Arnold, Shila Koju, Abby J. Wicks, Thomas E. Dowling

Biological Sciences Faculty Research & Creative Works

Hybridization is common among minnows and shiners in the family Leuciscidae, and mitonuclear discordance can reveal evidence of historical hybridization and introgression events that have shaped extant species and populations. We have identified a notable case of serial mitogenome replacement in populations of two shiner species, Luxilus zonatus and L. chrysocephalus, which are syntopic in drainages throughout the northern and eastern Ozark Interior Highlands of North America. These mitogenome replacement events involved L. zonatus acquiring the mitogenome of L. chrysocephalus, and populations of L. chrysocephalus acquiring the mitogenome of an allopatric congeneric species, L. cornutus. The latter species has a …

Dairy And Food Science News, Sept 2025, Department Of Dairy And Food Science

Dairy & Food Science News

Message from the Department Head
Dairy Drive Football Game
Dairy Foods Research @SDSU: Opportunities Galore Webinar
Faculty Updates
Faculty Surveys and Studies
Recruitment Updates & Opportunities
2025 Burger Bash
Meet our Jacks
Student Updates
2025 Eminent Leader in Agriculture, Family and Community
Events & Calendar

Growth Performance And Yield Of Two Bioguma Sorghum Varieties Cultivated During The Rainy Season [Research Note], M. Umar Harun, Irmawati Irmawati, Marlin Sefrila, Astuti Kurnianingsih, Chandra Irsan

The Philippine Agricultural Scientist

Sorghum is a cereal crop with significant potential, considering its benefits as a food, feed, or bioethanol source. Aside from being a drought-tolerant plant, sorghum can grow in different land conditions, with varieties Bioguma 1 and 2 considered to have high yield potential. Therefore, this study aimed to assess the growth and yield of these 2 sorghum varieties using a randomized block design with 3 replicates. The results showed that Bioguma 1 had a significantly better growth performance and produced a higher yield compared with Bioguma 2. Considering its higher disease resistance, growth, and yield, Bioguma 1 could be used …

Using Automated Activity Monitoring To Detect Resumption Of Cyclicity In Early Lactation—Meta-Analysis, S. Borchardt, T.A. Burnett, T.C. Bruinjé, A.M.L. Madureira

Dairy Science and Food Science Faculty Publications: 2022 to Present

This meta-analysis aimed to evaluate the efficacy of automated activity monitoring (AAM) in detecting estrous expression and ovulatory status in cows during the voluntary waiting period (VWP). A comprehensive literature search was conducted in PubMed, ScienceDirect, and Google Scholar using specific search terms. Inclusion criteria focused on studies that assessed estrous expression within the VWP using modern AAM systems alongside blood progesterone (P4) measurements. Four manuscripts involving 2,198 cows were included. Data extraction was performed by a single investigator and validated by a coauthor. The analysis considered estrous expression and ovulatory status determined through serial blood P4 measurements. Cows were …

The Official List Of The Birds Of Nebraska: 2024, Mark A. Brogie

Nebraska Bird Review

The duties of the Nebraska Ornithologists’ Union Records Committee (NOURC 2010) include:

A. The committee shall publish an official list of the birds of Nebraska.
B. The official list will include all those species whose occurrence has been reported in Nebraska (and approved by the NOURC).
C. The committee shall keep the official list current.
D. The committee shall publish a list of species for which details are requested with every sighting reported.

The 2024 NOURC has completed the above-described duties, and the following is a result of its endeavors.

The “Official List of the Birds of Nebraska” was last …

First Confirmed Nebraska Breeding Record Of The Common Raven (Corvus Corax) Since The 19th Century, Eugene A. Huryn, Jacob C. Cooper

Nebraska Bird Review

In Nebraska, the Common Raven was likely widespread prior to 1900, being codistributed with the American Bison (Bison bison). Records in this time are spotty, but consistent. Thomas Say reported a nearly fledged brood—the only confirmed breeding record in this period—at Fort Calhoun in Washington County on May 12, 1820. A Common Raven was collected at Fort Randall, on the Missouri River just north of the modern Nebraska–South Dakota border, in the fall of 1857 during the Lieutenant Warren Expeditions. Another specimen, now lost, was collected by J. B. Hasty in 1899 in Arapahoe, Furnas County. Bruner et …

Resource Assessment Report No. 5: West Coast Deep Sea Crustacean Resource 2024 Assessment, Emma-Jade Tuffley, Simon De Lestang

Resource Assessment Reports

The West Coast Deep Sea Crustacean resource consists of crystal crab (snow) (Chaceon albus), champagne crab (spiny) (Hypothalassia acerba) and giant crab (Pseudocarcinus gigas). The resource is mainly accessed by the commercial West Coast Deep Sea Crustacean Managed Fishery (WCDSCMF), which primarily targets crystal crabs. The West Coast Rock Lobster Managed Fishery (WCRLMF) also retains a small amount of champagne crabs as byproduct of deep-water rock lobster fishing. The WCDSCMF is a pot-based fishery using baited pots operated in a long-line formation in shelf edge waters ( > 150 m in depth) off the West …

Resource Assessment Report No. 3: Gascoyne Demersal Scalefish Resource 2024 Assessment, Emily A. Fisher, Rachel Marks, Sybrand A. Hesp, Ainslie Denham, Gary Jackson, David V. Fairclough

Resource Assessment Reports

The Gascoyne Demersal Scalefish Resource (GDSR) comprises over 80 species inhabiting inshore (20-250 m deep) and offshore ( > 250 m deep) waters in the Gascoyne Coast Bioregion (GCB; south of Onslow to north of Kalbarri). The GDSR is primarily targeted by commercial, charter and recreational boat-based line fishers. Snapper and Goldband Snapper are the indicator species selected for monitoring and assessing the status of the inshore suite of the GDSR, while Ruby Snapper and Greybanded Grouper are the indicators for the offshore suite.

Periodic assessments of GDSR indicator species demonstrated that historical fishing of Snapper led to stocks being below …

Resource Assessment Report No. 2: West Coast Demersal Scalefish Resource 2025 Assessment, Emily A. Fisher, David V. Fairclough, Elaine Lek, Jeremy Briggs, Sybrand Alex Hesp, Ainslie Denham

Resource Assessment Reports

The West Coast Demersal Scalefish Resource (WCDSR) comprises over 100 species inhabiting inshore (20-250 m deep) and offshore ( > 250 m deep) waters of the West Coast Bioregion (WCB; north of Kalbarri to east of Augusta). The WCDSR is primarily targeted by commercial, charter and recreational boat-based line fishers, including the commercial West Coast Demersal Scalefish (Interim) Managed Fishery (WCDSIMF). Indicator species selected for monitoring and assessing the status of the inshore suite of the WCDSR include Snapper, WA Dhufish and Baldchin Groper, while indicators for the offshore suite include Hapuku, Bass Groper and Blue-eye Trevalla.

The WCDSR is more …

Gene Expression Of Anthocyanin Pigments In The California Native Plant Leptosiphon Parviflorus: Interactions Between Flower Color Morphology And Abiotic Stressors, Weston Gonor

Master's Theses

For plants to survive in harsh conditions imposed by abiotic stressors, they must develop mechanisms of adaptation. One of the common types of adaptation seen in plants is the production of anthocyanin pigments, which have been shown to protect plants from UV radiation, metabolic stress, and drought. In this study, we used the flower color polymorphic species Leptosiphon parviflorus to investigate the role of anthocyanin pigments in protecting plants from abiotic stress. To accomplish this, RNA samples were taken from flower, leaf and root tissue of different flower color morphs of Leptosiphon parviflorus (Polemoniaceae) grown in high magnesium and water …

Identification And Characterization Of Peptide Responsive Histone Modification Genes During Root Nodule Symbiosis In Medicago Truncatula, Shivani Dharam

Tennessee State University Alumni Theses and Dissertations

Nitrogen (N) is an essential but limiting macronutrient for crop growth in agroecosystems. Biological Nitrogen Fixation (BNF) is a critical biological process where atmospheric Nitrogen is converted into ammonia by Nitrogen fixing the bacteria called rhizobia, forming mutualistic relationships with legume plants. These interactions are mediated by several signaling pathways and may involve epigenetic modifications like DNA methylations, histone modifications, where gene expression is altered without any change in DNA sequence. Histones are proteins provide structural support to DNA. However, genes encoding enzymes for these post translational modifications are poorly investigated in the Leguminosae family. This project aims to answer …

Understanding Performance And Egg Quality Parameters In A Pastured Egg-Type Poultry Breed, Biswajit Kumar Biswas

Tennessee State University Alumni Theses and Dissertations

This study investigated the effects of rearing systems on performance, egg quality, and ileal amino acid (AA) digestibility in laying hens (65 weeks of age). A total of 66 hens were distributed into two rearing systems: Cage (2 birds/replication, total 12 birds in 6 replications) and pasture (9 birds/replication, total 54 birds in 6 replications), and reared on three levels of energy diet (11.50 MJ/kg, 12.50 MJ/kg, and 13 MJ/kg). The birds were reared from d 1 to 14 (diet 1), d 15 to 28 (diet 2), and d 29-42 (diet 3). The average temperature, wind speed, and humidity were …

Fisheries Occasional Publication No. 149 - Economic Contribution Of Wild-Catch Fishing In Western Australia, 2024: Beyond Gross Value Of Production, Dipesh Maharjan, Vilaphonh Xayavong, Ben Fraser, Rebecca Thomas

Fisheries Occasional Publications

The wild-catch fishing industry plays a significant role in Western Australia’s economy, particularly in regional communities. This report summarises the economic contribution of the commercial wild-catch fishing sector in 2024, based on REMPLAN’s input-output (I-O) modelling methodology and DPIRD data and analysis. This report focuses on key economic indicators including total economic output, gross value added (GVA), and employment (FTEs).

Key findings:

• Total Economic Output of the wild-catch fishing industry is $1.22 billion (total value of goods and services produced, including intermediate inputs)
• Gross Value Added (GVA) of the wild-catch fishing industry is $487 million (value of profit, wages, salaries …

Comparison Of Gonad Development Between Wild And Hatchery-Bred Silver Therapon Leiopotherapon Plumbeus (Teleostei: Terapontidae) During An Annual Reproductive Cycle, Frolan A. Aya, Samantha Ally V. Bismonte, Mary Jane P. Sayco, Luis Maria B. Garcia

The Philippine Agricultural Scientist

This study compared gonad development between wild-sourced and hatchery-bred silver therapon Leiopotherapon plumbeus. Wild fish from the east bay area of Laguna de Bay, Philippines, and hatchery-bred stocks grown to adult size in outdoor tanks were sampled, and somatic condition, gonad histology, gonadosomatic index (GSI), gut index (GI), and hepatosomatic index (HSI) were assessed during the annual reproductive cycle. Hatcherybred fish condition was generally better than that of wild-sourced fish as a consequence of readily available food resources and environmental conditions. Hatchery-bred male GSIs were significantly higher than in wild male fish in November to February, coinciding with low water …

Influence Of Varying Levels Of Lactiplantibacillus Plantarum Inoculant On The Physicochemical Characteristics And Degradation Kinetics Of Corn Silage, Christian V. Lualhati, Kimberly Turaja, Le Chan P. Yu, Jonalyn M. Sandro, Angelica Maghirang Maria, Jimmy C. Espina Jr., Cedric M. Nerona, Reynald D. Amido, Mary Rose De Guia, Gerald Guadayo, Menandro M. Loresco, Arnel N. Del Barrio

The Philippine Agricultural Scientist

This study evaluated the effects of Lactiplantibacillus plantarum as an inoculant on the physical (color, odor, texture), chemical characteristics (pH, total soluble sugars [TSS], Flieg point [FP], dry matter [DM], organic matter [OM], ash, crude protein [CP], neutral detergent fiber [NDF], acid detergent fiber [ADF], and hemicellulose), and fermentation kinetics of corn silage. Treatments were 0% (T1), 1% (T2), 2% (T3), and 3% (T4) concentration of L. plantarum applied to corn before ensiling for 21 d. Afterwards, an in situ experiment was immediately conducted to test the digestibility of corn silage at 3, 6, 12, 24, 48, and 72 h …

Evaluation Of Semen Characteristics And The Impact Of Storage Time In Dong Tao And Ho Indigenous Chickens, Phan Nhan, Nguyen Thi My Phuong

The Philippine Agricultural Scientist

This study aimed to evaluate the semen quality of 2 indigenous Vietnamese chicken breeds, Dong Tao and Ho, and to assess their reproductive potential for breeding and conservation programs. Semen samples were collected from 10 roosters of each breed and analyzed for macroscopic and microscopic traits. The results indicated that both breeds exhibited semen quality within acceptable physiological ranges. Mean semen volume was 0.47 mL in Dong Tao and 0.48 mL in Ho roosters; pH values were 7.47 and 7.42, respectively. Semen color scores (2.39 vs. 2.35), sperm concentrations (2.11 vs. 1.92 × 109/mL), and mass activity scores (3.79 vs. …

Summer Field Report, June–July 2025, W. Ross Silcock

Nebraska Bird Review

I have mentioned previously the breeding categories that are available to observers in eBird checklists. This database is becoming more comprehensive and useful, and I encourage observers to use this eBird feature.

Usefulness of Merlin-derived checklists continues to be an issue. As an example, Merlin seems to love White-winged Doves; there were 52 undocumented Merlin reports of this species this summer, no doubt some correctly identified and acceptable if observers had taken a minute to add even minimal observation details to support Merlin’s identifications.

A vexing issue for me is determining the status of midsummer (i.e. between spring and fall …

The Nebraska Bird Review (September 2025) 93(3), Whole Issue

Nebraska Bird Review

Summer Field Report, June–July 2025, by W. Ross Silcock

First Confirmed Nebraska Breeding Record of the Common Raven (Corvus corax) since the 19th Century, by Eugene A. Huryn and Jacob C. Cooper

2024 (36th) Report of the NOU Records Committee, by Mark A. Brogie

The Official List of the Birds of Nebraska: 2024, compiled by Mark A. Brogie

Subscription and Organization Information

2024 (36th) Report Of The Nou Records Committee, Mark A. Brogie

Nebraska Bird Review

The functions and methods of the Nebraska Ornithologists’ Union Records Committee (NOURC) are described in its bylaws (NOURC 2010). The committee’s purpose is to provide a procedure for documenting unusual bird sightings and to establish a list of all documented birds for Nebraska. Species for which the NOURC seeks documentation (NOURC Review List) can be found at the NOU website: www.NOUbirds.org.

Starting in 2020, the NOURC decided to deal mainly with those species deemed as Accidental on the “Official List of the Birds of Nebraska.” Casual species and out-of- range species are now summarized in the “Seasonal Reports” of the …

Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive and heterogeneous molecular subtype of breast cancer that has limited available treatments. The organometallic cationic ruthenium derivative Ru-IM was found to be highly water soluble, was differentially toxic for breast cancer cells and tumors, and was involved in the pI3K/AKT/mTOR pathway. However, a full understanding of genetic and epigenetic factors that can be part of regulatory mechanisms of Ru-IM is yet to be determined. Epigenetic assays including DNA methylation, histone acetylation and histone deacetylation were performed with the half inhibitory concentration (IC50) values of Ru-IM. Bisulfite sequencing of untreated and treated MDA-MB-231 …

Ai-Powered Multi-Omics Integration For Predictive Modeling Of Genotype-Environment-Phenotype Relationships, You Wu

Dissertations, Theses, and Capstone Projects

This dissertation presents a series of machine learning frameworks for modeling genotype–environment–phenotype relationships through integrative predictive modeling of multi-omics data. The work addresses three major axes of biological complexity: modeling biological information transmission cross-levels from genes to proteins to phenotypes, predicting molecular features cross-scale from cells to tissues to organisms, and translating phenotypes cross-species from model systems to humans. Each proposed method also tackles key machine learning (ML) challenges in the biomedical domain, including data scarcity, domain shift, out-of-distribution (OOD) generalization, and hierarchical modeling. Specifically, this dissertation introduces five novel deep learning algorithms: MultiDCP predicts drug-induced transcriptomic and viability responses …

Origin And Maintenance Of The Andean Bird Fauna, Elkin A. Tenorio

Dissertations, Theses, and Capstone Projects

The origin and maintenance of the tropical montane diversity have been evaluated over multiple decades using various techniques and perspectives. Despite major progress in understanding phylogenetic relationships, diversification patterns, distributional data, and general ecology in the Andean biota, large gaps in our understanding remain, particularly in the synthesis across scales. To fill these gaps, I aimed to explore patterns and processes that underlie species diversification in birds of the tropical Andes of South America by combining different approaches using phenotypic, phylogenetic, and genomic data in multiple temporal and spatial scales.

In the first chapter, I examined the macroevolutionary patterns of …

The Sonic Hedgehog Effector Smoothened Modulates Cholinergic Interneuron Activity, Physiology, And Striatum-Dependent Behaviors, Santiago Uribe-Cano

Dissertations, Theses, and Capstone Projects

The striatum is a central node in action selection and associative learning, integrating cortical, thalamic, and neuromodulatory input. Among its principal modulators, dopamine (DA) and acetylcholine (ACh) are known for their temporally coordinated yet mechanistically distinct influences on striatal output. However, the upstream signals that regulate their dynamic interplay, particularly within cholinergic interneurons (CINs)—the primary source of striatal ACh—remain incompletely characterized. This dissertation investigates the role of Smoothened (Smo), a G protein-coupled receptor (GPCR) effector of Sonic Hedgehog (Shh) signaling, in modulating ACh signaling dynamics in the striatum.

Building on evidence that midbrain DA neurons co-release Shh and that CINs …

Bmp Signaling Co-Regulation Of Immune Response And Lipid Metabolism, Katerina K. Yamamoto

Dissertations, Theses, and Capstone Projects

The Bone Morphogenetic Proteins (BMPs) are secreted peptide ligands of the Transforming Growth Factor beta (TGF-β) family, initially identified for their roles in development and differentiation across animal species. They are now increasingly recognized for their roles in physiology and infectious disease. In the nematode Caenorhabditis elegans, the BMP ligand DBL-1 controls fat metabolism and immune response, in addition to its roles in body size regulation and development. DBL-1 regulates classical aspects of innate immunity, including the induction of anti-microbial peptides. We theorized that BMP-dependent regulation of fat metabolism could also promote resilience against microbial pathogens. We found that …

Detecting Sonic Hedgehog Expression In The Adult Mouse Brain Using A Gene Expression Tracer, Kendra Stephens-Jones

Dissertations, Theses, and Capstone Projects

Sonic Hedgehog (Shh) is best known for its role in development, yet evidence supports Shh signaling plays a functional role in the adult brain. Previous work demonstrated that Shh is expressed by dopamine (DA) neurons in the ventral midbrain and that loss of Shh from these neurons leads to late-onset motor and structural abnormalities resembling Parkinson’s disease. However, the extent of Shh expression and its connectivity to the striatum in the adult mouse brain remain unclear due to the lack of reliable antibodies for Shh detection. To address this gap, the present study employed Shh ^L/L and DAT-Cre^+/- mice …

Mechanisms Of Sleep Regulation In Drosophila Melanogaster, Anfal A. Abuhilal

Dissertations, Theses, and Capstone Projects

Sleep is a fundamental biological need, and sufficient sleep is required for physical and mental well-being. Sleep is regulated by two biological mechanisms: sleep-wake homeostasis and circadian rhythm. Circadian rhythms are near 24-h rhythms in behavior and physiology that are generated by endogenous mechanisms. In mammals, the suprachiasmatic nucleus (SCN) is the central circadian pacemaker, which is known to receive a significant amount of serotonergic input that likely modulates sleep rhythms. In addition to circadian modulation, sleep is subject to homeostatic regulation. Several neuromodulators have been proposed as mediators of sleep homeostasis. Serotonin has been implicated in sleep drive and …