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Articles 3301 - 3330 of 114079
Full-Text Articles in Entire DC Network
Ground-Based Modeling Of Deep-Space Risks To The Spleen And Intestine In Mice, Edith Nathalie Pineda Sotomayor
Ground-Based Modeling Of Deep-Space Risks To The Spleen And Intestine In Mice, Edith Nathalie Pineda Sotomayor
Theses and Dissertations
Deep-space missions, such as those planned for the cis-lunar space and Mars, pose unique challenges to astronaut health due to prolonged microgravity (MG) exposure and low-dose chronic irradiation (CIR). Understanding the impact of these stressors on secondary lymphoid tissues, such as the spleen and intestine, is crucial for ensuring crewmembers' well-being, given the impracticality of conducting this research with human samples. Using a ground-based facility, we exposed C57BL/6 female and male mice to CIR (1.74 Gy at a dose rate of 0.0029 Gy/h) and/or simulated MG (SMG) via hind limb unloading (HLU) for one month. Spleen and intestinal tissues were …
Variability In Arthropod Community Surveys: Observations Of Ground-Dwelling Arthropods Are Dependent On Methodological Choices, Katherine Mcnamara Manning, Kayla I. Perry, Christie A. Bahlai
Variability In Arthropod Community Surveys: Observations Of Ground-Dwelling Arthropods Are Dependent On Methodological Choices, Katherine Mcnamara Manning, Kayla I. Perry, Christie A. Bahlai
The Great Lakes Entomologist
Sampling approaches are commonly adapted to reflect the study objectives in biodiversity monitoring projects. This approach optimizes findings to be locally relevant but comes at the cost of generalizability of findings. Here, we detail a comparison study directly examining how researchers’ choice of arthropod trap and level of specimen identification affects observations made in small-scale arthropod biodiversity studies. Four arthropod traps (pitfall traps, yellow ramp traps, yellow sticky cards, and novel jar ramp traps) were compared with respect to an array of biodiversity metrics calculated at two levels of identification. The arthropod community captured varied by trap type. Pitfalls and …
Nest Pollen Provisions From An Urban Population Of Megachile Campanulae (Hymenoptera: Megachilidae) In Minnesota Are Consistent With Oligolectic Classification., Lam D. Le, Thea A. Evans, Colleen Satyshur
Nest Pollen Provisions From An Urban Population Of Megachile Campanulae (Hymenoptera: Megachilidae) In Minnesota Are Consistent With Oligolectic Classification., Lam D. Le, Thea A. Evans, Colleen Satyshur
The Great Lakes Entomologist
The conservation of bees is crucial for maintaining the essential ecological services they provide. Understanding bee species' risk of extinction is a key part of conservation efforts, and can include assessment of dietary specialization, which has been linked to higher extinction risk. Dietary specialization in bees, called oligolecty, occurs when females select pollen only from closely related plants to feed their larvae. While the solitary bee, Megachile (Chelostomoides) campanulae (Robertson 1903), has been associated with flowers in the genus Campanula L. (Campanulaceae: Asterales), evidence from pollen analysis is limited, and dietary classification is reported inconsistently. This study examined dietary specialization …
Initial Changes In Ground Beetle (Carabidae: Coleoptera) Assemblages After Creating Gaps Of Varying Sizes In Mature Northern Hardwoods Forests In Wisconsin, Robert A. Haack, Robert E. Acciavatti, Toby R. Petrice, Robert L. Davidson, Terry F. Strong
Initial Changes In Ground Beetle (Carabidae: Coleoptera) Assemblages After Creating Gaps Of Varying Sizes In Mature Northern Hardwoods Forests In Wisconsin, Robert A. Haack, Robert E. Acciavatti, Toby R. Petrice, Robert L. Davidson, Terry F. Strong
The Great Lakes Entomologist
Managers of northern hardwood forests in the Great Lakes region create gaps in the forest canopy of various sizes during harvesting to achieve different silvicultural objectives. Single-tree harvesting favors recruitment of shade-tolerant tree species by creating small gaps in the canopy, whereas group selection creates larger gaps that can favor shade-intolerant tree species. We evaluated changes in carabid beetle abundance and diversity in harvest-created gaps of five sizes (gap diameters of 6, 10, 20, 30, and 46 m) and uncut forests in northern Wisconsin where sugar maple (Acer saccharum) was the dominant tree species. Gaps were cut during …
From Venom To Medicine: Harnessing Animal Toxins For Drug Discovery, Christine Vega, Ying Jia
From Venom To Medicine: Harnessing Animal Toxins For Drug Discovery, Christine Vega, Ying Jia
Research Colloquium
Background: Drug development research has long focused on synthesizing novel therapeutics while overlooking isolation from naturally available sources such as animal venoms. Recently, the discovery of the therapeutic effects of highly bioavailable animal venom caused the field of venom research to soar in popularity. Animal venom serves as a natural, sophisticated tool optimized over millions of years by evolution with the ability to bind to ion channels such as nAChRs, non-specific ligand-gated ion channels distributed throughout the human nervous system. However, purifying individual venom toxins from crude venom is challenging due to its availability. Therefore, synthesizing large quantities of venom …
Arbuscular Mycorrhizal Fungi As Key Drivers Of Plant Resilience: Mechanisms Of Stress Adaptation In Saline Environments, Rayna Elizabeth Koberstein
Arbuscular Mycorrhizal Fungi As Key Drivers Of Plant Resilience: Mechanisms Of Stress Adaptation In Saline Environments, Rayna Elizabeth Koberstein
Dissertations and Theses
Arbuscular mycorrhizal fungi (AMF) play a critical role in mediating plant responses to environmental stress, yet their ecological significance in saline wetland restoration remains underexplored. This greenhouse experiment investigated the effects of salinity, root-zone barrier type (solid, mesh, none), and neighboring species identity on AMF colonization and physiological responses in three native estuarine plants: Carex densa, Juncus patens, and Scirpus microcarpus. Results demonstrated species-specific physiological responses to salinity, with Juncus patens showing greater resilience in maintaining photosynthetic efficiency (Fv/Fm) and percent cover at higher salinity levels, while Scirpus microcarpus exhibited a significant decline. Mesh barriers, which permitted …
Sensory And Chemical Characterization Of Upcycled Pomace- And Whey-Based Piquette Beverages, Dean G. Hauser, Rahul Sen, Scott R. Lafontaine, Chris Gerling, Luann M. Preston-Wisley, Timothy A. Demarsh, Samuel D. Alcaine
Sensory And Chemical Characterization Of Upcycled Pomace- And Whey-Based Piquette Beverages, Dean G. Hauser, Rahul Sen, Scott R. Lafontaine, Chris Gerling, Luann M. Preston-Wisley, Timothy A. Demarsh, Samuel D. Alcaine
Food Science Faculty Publications and Presentations
Upcycling, or utilizing materials that would otherwise go to waste, enables the creation of novel products that offer sustainability advantages and generate additional value. This study evaluates the feasibility of producing alcoholic beverages using yogurt acid whey (YAW) and grape pomace (GP), byproducts of the dairy and wine industries, respectively, and compares them to commercial grape pomace beverages (piquettes) in terms of sensory attributes and chemical composition. Two YAW-GP piquettes were produced, and five commercial piquettes were obtained. Sugars and organic acids were quantified using HPLC-RID, and semi-quantitative volatile composition was determined using HS-SPME-GC-MS/MS. Descriptive analysis was conducted using a …
Nanovesicles Derived From Protocorm-Like Bodies Of Dendrobium Officinal Enhance Corneal Epithelial Repair And Reduce Inflammation In Dry Eye Disease Models, Bao Yuqing, Peng Chengyu, Zhang Fenglei, Zheng Yuqiang, Zhang Mingqi, He Wei
Nanovesicles Derived From Protocorm-Like Bodies Of Dendrobium Officinal Enhance Corneal Epithelial Repair And Reduce Inflammation In Dry Eye Disease Models, Bao Yuqing, Peng Chengyu, Zhang Fenglei, Zheng Yuqiang, Zhang Mingqi, He Wei
Journal of Food and Drug Analysis
Plant-derived nanovesicles (PDNVs) offer a promising, biocompatible therapeutic platform. In this study, we isolatednanovesicles from protocorm-like bodies of Dendrobium officinale (PLBs-NVs) and evaluated their efficacy in dry eyedisease (DED) models. PLBs-NVs protected human corneal epithelial cells against hyperosmotic stress, supportedwound repair, and inhibited inflammation in vitro. In a desiccating stress-induced DED mouse model, topical PLBs-NVstreatment significantly restored tear secretion, reduced corneal epithelial damage, and lowered levels of proinflammatorycytokines. These results suggest that PLBs-NVs are a safe, natural, and effective therapeutic strategy for DED, sup-porting their potential for future clinical translation in ocular surface disorders.
Protective Effects Of Jujube Seed Extract Against Oxidative Stress In Ht22 Cells And Its Sleep-Promoting Action Through Gabaergic Receptors, Seok Hyun Chung, Hyeongyeong Kim, Singeun Kim, Pan-Young Jeong, Hyowon Lee
Protective Effects Of Jujube Seed Extract Against Oxidative Stress In Ht22 Cells And Its Sleep-Promoting Action Through Gabaergic Receptors, Seok Hyun Chung, Hyeongyeong Kim, Singeun Kim, Pan-Young Jeong, Hyowon Lee
Journal of Food and Drug Analysis
Jujube seed extract (JSE), rich in polyphenols and flavonoids, exhibits neuroprotective and sleep-enhancing properties.In vitro, JSE protected HT22 cells against oxidative stress by activating the Nrf2/HO-1 pathway and upregulatingantioxidant enzymes. In vivo, JSE increased non-REM sleep and delta wave activity in pentobarbital- and caffeine-induced sleep models. Spinosin contributed to these effects. Long-term JSE administration upregulated GABAA, GABAB, and 5-HT1A receptors in brain tissue. These findings suggest that JSE offers dual benefits in mitigating oxidativestress and promoting sleep through antioxidant defense and neurotransmitter modulation, supporting its potential as a natural therapeutic agent.
Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models, Si-Si Han, Li-Yun Song, Peng-Tao Liang, Yin-Ying Wang, Yi Ying, Li Li, Jia-Li Yuan, Zhong-Shan Yang
Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models, Si-Si Han, Li-Yun Song, Peng-Tao Liang, Yin-Ying Wang, Yi Ying, Li Li, Jia-Li Yuan, Zhong-Shan Yang
Journal of Food and Drug Analysis
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by various pathologicallesions and an imbalance in the microflora. The Yi-Qi-Xuan-Fei Formula (YQXF) is a clinically effective formula withpharmacological potential to delay the progression of COPD. This study aims to explore the relationship between thetherapeutic mechanism of YQXF and the microflora in COPD. Our study found that YQXF reduces inflammatory injuryand inflammatory cell infiltration in lung tissue, repairs the intestinal mucosal barrier, and enhances immune function.Additionally, YQXF regulates the pulmonary and intestinal flora by increasing the abundance of Alloprevotella, Rose-buria, Oscillibacter, and Lactobacillus, while reducing the abundance of …
Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma
Precision Nanomedicine For Anxiety: Challenges, Opportunities, And Future Directions In Targeted Drug Delivery, Sehrabpreet Singh, Amanpreet Singh, Shruti Chittu, Shailesh Sharma
Journal of Food and Drug Analysis
Nanoparticle-based drug delivery system represents one of the challenging strategies suggested to improve anxietydisorder therapeutic approaches, clinic challenges of delayed action, side effect-free designing and poor patientcompliance. Traditional pharmacological agents can increase drug bioavailability and target specific brain regions,whereas nanoparticle-mediated controlled release offers enhanced precision and sustained action. The others in thisreview concentrate on several kinds of nanoparticle, including lipid-based, polymeric-metallic, and responsive nano-particles, their use in anxiety medication. In addition, emphasis is placed on precision medicine that pertain the delivery of treatment based on an individual's genetic, environmental and lifestyle aspects. Also, it is looked into how artificial intelligence …
The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh
The Rhythm Of Decline: Circadian Disruption In Neurodegeneration, Jeewanjot Singh, Devinder Kumar, Jasleen Kaur, Amanpreet Singh
Journal of Food and Drug Analysis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology involving genetic,environmental, and metabolic factors. Among these, circadian rhythm disruption has emerged as a crucial but under-explored contributor to disease progression. The circadian system, regulated by the suprachiasmatic nucleus (SCN),controls essential physiological functions such as the sleep-wake cycle, metabolism, and neuroendocrine signaling.Disruption of this system has been increasingly linked to key pathological features of AD, including amyloid-betaaccumulation, tau hyperphosphorylation, and neuroinflammation. This review critically examines the mechanistic roleof circadian misalignment in AD by analyzing studies on sleep disturbances, SCN degeneration, metabolic dysregu-lation, clock gene polymorphisms (BMAL1, CLOCK, PER, …
Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar
Targeted Nanosponge-Based Treatment For Pulmonary Hypertension: A Novel Approach, Jashanpreet Kaur, Gursimran Kaur, Chamanpreet Kaur, Sandeep Kumar
Journal of Food and Drug Analysis
Pulmonary Hypertension (PH) is a progressive and potentially fatal condition marked by high pulmonary arterypressure, resulting in heart failure and reduced oxygenation. Despite advancements in treatments, therapeutic optionsfor PH remain limited, particularly in cases resistant to conventional therapies. In biomedical research, nanotechnologyhas become a potential area of study, presenting novel approaches to drug delivery and tissue targeting. Nanosponges, aclass of nanoparticles with porous structures, have gained attention for their ability to encapsulate therapeutic agents,enhance drug stability, and provide controlled release. Nanosponges can be engineered to deliver vasodilators, anti-inflammatory drugs, and gene therapies directly to the pulmonary vasculature, minimizing systemic side …
In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar
In Vivo And In Vitro Perspectives In Parkinson's Disease: Mechanisms And The Role Of Phytomedicine, Jeewanjot Singh, Devinder Kumar
Journal of Food and Drug Analysis
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by dopaminergic neuronal loss,oxidative stress, neuroinflammation, and a-synuclein aggregation. Despite advances, current treatments only offersymptomatic relief without altering disease progression. This review aims to evaluate the therapeutic potential of plant-derived phytochemicals in PD through evidence from both in vivo and in vitro experimental models. Key findingsindicate that rodent models (e.g., MPTP, rotenone) and neuronal cell lines (e.g., SH-SY5Y) help replicate PD pathologyand mechanistic insights. Phytochemicals such as baicalein, morin, ferulic acid, and bacopa demonstrate neuroprotectiveeffects via antioxidant, anti-inflammatory, and mitochondrial-stabilizing pathways. Nanotechnology and brain orga-noids further improve translational relevance. In conclusion, …
Warming Induces Unexpectedly High Soil Respiration In A Wet Tropical Forest, Tana E. Wood, Colin Tucker, Aura M. Alonso-Rodríguez, M. Isabel Loza, Iana F. Grullón-Penkova, Molly A. Cavaleri, Christine S. O'Connell, Sasha C. Reed
Warming Induces Unexpectedly High Soil Respiration In A Wet Tropical Forest, Tana E. Wood, Colin Tucker, Aura M. Alonso-Rodríguez, M. Isabel Loza, Iana F. Grullón-Penkova, Molly A. Cavaleri, Christine S. O'Connell, Sasha C. Reed
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Tropical forests are a dominant regulator of the global carbon cycle, exchanging more carbon dioxide with the atmosphere than any other terrestrial biome. Climate models predict unprecedented climatic warming in tropical regions in the coming decades; however, in situ field warming studies are severely lacking in tropical forests. Here we present results from an in situ warming experiment in Puerto Rico, where soil respiration responses to +4 oC warming were assessed half-hourly for a year. Soil respiration rates were 42-204% higher in warmed relative to ambient plots, representing some of the highest soil respiration rates reported for any …
Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J Purwin, Casey D Stefanski, Renaira Oliveira Da Silva, Mitchell E Fane, Yash Chhabra, Jelan I Haj, Jessica Lf Teh, Rama Kadamb, Weijia Cai, Sheera R Rosenbaum, Vivian Chua, Nir Hacohen, Michael A Davies, Jessie Villanueva, Inna Chervoneva, Ashani T Weeraratna, Dan A Erkes, Claudia Capparelli, Julio A Aguirre-Ghiso, Andrew E Aplin
Elevated Nr2f1 Underlies The Persistence Of Invasive Disease After Treatment Of Braf-Mutant Melanoma, Manoela Tiago, Timothy J Purwin, Casey D Stefanski, Renaira Oliveira Da Silva, Mitchell E Fane, Yash Chhabra, Jelan I Haj, Jessica Lf Teh, Rama Kadamb, Weijia Cai, Sheera R Rosenbaum, Vivian Chua, Nir Hacohen, Michael A Davies, Jessie Villanueva, Inna Chervoneva, Ashani T Weeraratna, Dan A Erkes, Claudia Capparelli, Julio A Aguirre-Ghiso, Andrew E Aplin
Faculty, Staff and Student Publications
Despite the success of targeted inhibitors in cutaneous melanoma, therapeutic responses are limited by the aged tumor microenvironment and drug-tolerant residual cells. Given the similarities between drug tolerance and cellular dormancy, we studied the dormancy marker, nuclear receptor subfamily 2 group F member 1 (NR2F1), in response to BRAF-V600E inhibitors (BRAFi) plus MEK inhibitors (MEKi) in BRAF-mutant melanoma models. Transcriptomic analysis of melanoma patient samples treated with BRAFi + MEKi showed increased NR2F1. NR2F1 was highly expressed in the drug-tolerant invasive cell state of minimal residual disease in patient-derived and mouse-derived xenografts on BRAFi + MEKi. NR2F1 over-expression was sufficient …
33 Unresolved Questions In Nanoscience And Nanotechnology, Chad A Mirkin, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydin, Austin Biaggne, C Jeffrey Brinker, Katherine E Bujold, Y Charles Cao, Rachel R Chan, Chaojian Chen, Peng-Cheng Chen, Xiaodong Chen, Olivier J G L Chevalier, Chung Hang Jonathan Choi, Richard M Crooks, Vinayak P Dravid, Jingshan S Du, Sasha B Ebrahimi, Hongyou Fan, Omar K Farha, C Adrian Figg, Tanner D Fink, Connor M Forsyth, Harald Fuchs, Franz M Geiger, Nathan C Gianneschi, Kyle J Gibson, David S Ginger, Sishi Guo, Justin S Hanes, Liangliang Hao, Jin Huang, Bryan M Hunter, Fengwei Huo, Jeongmin Hwang, Rongchao Jin, Shana O Kelley, Thomas J Kempa, Youngeun Kim, Sergej Kudruk, Sneha Kumari, Kaitlin M Landy, Ki-Bum Lee, Noel J Leon, Jun Li, Yuanwei Li, Zhiwei Li, Bin Liu, Guoliang Liu, Xiaogang Liu, Luis M Liz-Marzán, Jochen H Lorch, Taokun Luo, Robert J Macfarlane, Jill E Millstone, Milan Mrksich, Catherine J Murphy, Rajesh R Naik, Andre E Nel, Christopher Oetheimer, Jenny K Hedlund Orbeck, So-Jung Park, Benjamin E Partridge, Nicholas A Peppas, Michelle L Personick, Arindam Raj, Namrata Ramani, Michael B Ross, Stacey Barnaby Ross, Edward H Sargent, Tanushri Sengupta, George C Schatz, Dwight S Seferos, Tamar Seideman, Soyoung Eileen Seo, Bo Shen, Wooyoung Shim, Donghoon Shin, Ulrich Simon, Andrew J Sinegra, Peter T Smith, Alexander M Spokoyny, Peter J Stang, Alexander H Stegh, J Fraser Stoddart, Dayne F Swearer, Weihong Tan, Michelle H Teplensky, C Shad Thaxton, David R Walt, Mary X Wang, Zhe Wang, Wei David Wei, Paul S Weiss, Peter H Winegar, Younan Xia, Yi Xie, Xiaoyang Xu, Peidong Yang, Yiming Yang, Zihao Ye, Kuk Ro Yoon, Cuizheng Zhang, Hua Zhang, Ke Zhang, Liangfang Zhang, Xiaoyu Zhang, Ye Zhang, Zijian Zheng, Wenjie Zhou, Shengshuang Zhu, Wei Zhu
33 Unresolved Questions In Nanoscience And Nanotechnology, Chad A Mirkin, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydin, Austin Biaggne, C Jeffrey Brinker, Katherine E Bujold, Y Charles Cao, Rachel R Chan, Chaojian Chen, Peng-Cheng Chen, Xiaodong Chen, Olivier J G L Chevalier, Chung Hang Jonathan Choi, Richard M Crooks, Vinayak P Dravid, Jingshan S Du, Sasha B Ebrahimi, Hongyou Fan, Omar K Farha, C Adrian Figg, Tanner D Fink, Connor M Forsyth, Harald Fuchs, Franz M Geiger, Nathan C Gianneschi, Kyle J Gibson, David S Ginger, Sishi Guo, Justin S Hanes, Liangliang Hao, Jin Huang, Bryan M Hunter, Fengwei Huo, Jeongmin Hwang, Rongchao Jin, Shana O Kelley, Thomas J Kempa, Youngeun Kim, Sergej Kudruk, Sneha Kumari, Kaitlin M Landy, Ki-Bum Lee, Noel J Leon, Jun Li, Yuanwei Li, Zhiwei Li, Bin Liu, Guoliang Liu, Xiaogang Liu, Luis M Liz-Marzán, Jochen H Lorch, Taokun Luo, Robert J Macfarlane, Jill E Millstone, Milan Mrksich, Catherine J Murphy, Rajesh R Naik, Andre E Nel, Christopher Oetheimer, Jenny K Hedlund Orbeck, So-Jung Park, Benjamin E Partridge, Nicholas A Peppas, Michelle L Personick, Arindam Raj, Namrata Ramani, Michael B Ross, Stacey Barnaby Ross, Edward H Sargent, Tanushri Sengupta, George C Schatz, Dwight S Seferos, Tamar Seideman, Soyoung Eileen Seo, Bo Shen, Wooyoung Shim, Donghoon Shin, Ulrich Simon, Andrew J Sinegra, Peter T Smith, Alexander M Spokoyny, Peter J Stang, Alexander H Stegh, J Fraser Stoddart, Dayne F Swearer, Weihong Tan, Michelle H Teplensky, C Shad Thaxton, David R Walt, Mary X Wang, Zhe Wang, Wei David Wei, Paul S Weiss, Peter H Winegar, Younan Xia, Yi Xie, Xiaoyang Xu, Peidong Yang, Yiming Yang, Zihao Ye, Kuk Ro Yoon, Cuizheng Zhang, Hua Zhang, Ke Zhang, Liangfang Zhang, Xiaoyu Zhang, Ye Zhang, Zijian Zheng, Wenjie Zhou, Shengshuang Zhu, Wei Zhu
Faculty, Staff and Student Publications
Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this Nano Focus, we pose and explore 33 questions whose answers could profoundly impact fields such as energy, electronics, the environment, optics, and medicine. These questions highlight the need for deeper foundational understanding, improved tools …
A Single-Dose Long-Lasting Live-Attenuated Chimeric Vaccine Candidate Against The Emerging Tick-Borne Kyasanur Forest Disease, Young-Min Lee
A Single-Dose Long-Lasting Live-Attenuated Chimeric Vaccine Candidate Against The Emerging Tick-Borne Kyasanur Forest Disease, Young-Min Lee
Funded Research Records
No abstract provided.
Clinical Applications Of Probiotics: A Comprehensive Review Of Benefits And Challenges, Riyam Wissam Hassan
Clinical Applications Of Probiotics: A Comprehensive Review Of Benefits And Challenges, Riyam Wissam Hassan
Maaen Journal for Medical Sciences
Probiotics are beneficial microorganisms that help balance microbes in intestines and promote growth beneficial bacteria, they vary between bacteria, yeasts, and fungi and they are helpful to human health when taken in adequate and suitable amounts. In addition to maintaining intestinal health and help with digestion and absorption, also inhibiting development and preventing spread of harmful microorganisms. It exists in different forms, in the intestines and in the foods, products fermented, and in the pharmaceutical supplements. Because human health depends largely on the interaction between humans and these microorganisms known as probiotics, it has found that these organisms have vital …
Two New Species Of Uroplectes Peters, 1861 (Scorpiones, Buthidae) From Somaliland And Mozambique, František Kovařík
Two New Species Of Uroplectes Peters, 1861 (Scorpiones, Buthidae) From Somaliland And Mozambique, František Kovařík
Euscorpius
Two new species, Uroplectes elmii sp. n. from Somaliland and U. mossambicensis sp. n. from Mozambique are described, fully illustrated with color photos showing their morphology. Both species are similar to Uroplectes fischeri (Karsch, 1879) from which they differ mainly in finger dentition (Uroplectes elmii sp. n.) and strongly reduced tibial spurs on legs III–IV (U. mossambicensis sp. n.). Uroplectes elmii sp. n. is also compared with U. pardii Kovařík, 2003, from which it differs mainly by extremely reduced to absent metasomal punctation. A distribution map of all …
Influence Of Variable Climate On Mechanical Properties Of Composite Materials: An Experimental Study, Alexandra Tazhibaeva, Safaa M.R.H. Hussein, Mikhail Kuznetsov, Farid Shakirzyanov, Nikita Kharin, Igor Muravyev, Timur Agliullin, Gulshat Saleeva, Victor Mitryakin, Oleg Morozov, Oskar Sachenkov
Influence Of Variable Climate On Mechanical Properties Of Composite Materials: An Experimental Study, Alexandra Tazhibaeva, Safaa M.R.H. Hussein, Mikhail Kuznetsov, Farid Shakirzyanov, Nikita Kharin, Igor Muravyev, Timur Agliullin, Gulshat Saleeva, Victor Mitryakin, Oleg Morozov, Oskar Sachenkov
Karbala International Journal of Modern Science
This study investigates the degradation of carbon fiber-reinforced plastic composites, fabricated via non-autoclave molding, under tropical climatic conditions across three regions over three years. Forty specimens (10 control, 30 exposed) with 2x2 twill weave and 0°/90° fiber orientation were subjected to tensile and compressive testing, microscopy, and X-ray computed tomography. Control specimens established baseline properties, while exposed specimens underwent three-year weathering. Statistical and principal component analyses revealed significant mechanical degradation, with tensile strength decreasing by up to 16.1% (p
Impact Of Plasma-Activated Water On Breast Cancer Cell Viability, Maryam G. Jasim, Hammad R. Humud
Impact Of Plasma-Activated Water On Breast Cancer Cell Viability, Maryam G. Jasim, Hammad R. Humud
Karbala International Journal of Modern Science
Plasma-activated water (PAW) was generated using a dielectric barrier discharge (DBD) plasma system operating with a 1:1 mixture of nitrogen and argon gases to evaluate its cytotoxic effects on MCF-7 breast cancer cells. Water samples were divided into five groups: 0 minutes (control), 5, 10, 15, and 20 minutes of plasma exposure. The resulting PAW was applied to cultured cells, and cell viability was assessed 24- and 48-hour post-treatment. Viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed an apparent time-dependent increase in cytotoxicity. At 24 hours, cell mortality rates were 1.9%, 40.7%, 48.1%, 53.6%, …
Research Progress In Aflatoxin Degradation Technologies For Edible Oils, Huishuai Li, Zhenning Li, Yu Xie, Yunfeng Zou, Shaojun Li
Research Progress In Aflatoxin Degradation Technologies For Edible Oils, Huishuai Li, Zhenning Li, Yu Xie, Yunfeng Zou, Shaojun Li
Journal of Food Science and Biotechnology
Aflatoxin (AF),a notorious contaminant,has been a persistent challenge to the safety of edible oils.Prolonged exposure to low doses or acute consumption of high amounts of AF may induce serious health issues.Currently,no method can completely eliminate AF from edible oils.Therefore,it is crucial to explore strategies for reducing AF levels in edible oils.The measures to degrade AF from edible oils were reviewed,mainly including physical methods (such as high-temperature treatment,ray irradiation,and adsorption ),chemical methods (such as ammonia fumigation and ozone oxidation ),and biological methods (such as microbial degradation ).In addition,this paper analyzed and discussed the principles,advantages,shortcomings,and safety of various degradation methods.Furthermore,it made an …
Optimization Of Fermentation Conditions For The Removal Of Zearalenone From Corn Gluten Feed By Aspergillus Niger Fs10, Mengying Wu, Yang Yang, Jinyao Wang, Yongli Ye, Li’Na Sheng, Jian Ji, Xiulan Sun
Optimization Of Fermentation Conditions For The Removal Of Zearalenone From Corn Gluten Feed By Aspergillus Niger Fs10, Mengying Wu, Yang Yang, Jinyao Wang, Yongli Ye, Li’Na Sheng, Jian Ji, Xiulan Sun
Journal of Food Science and Biotechnology
[Objective ] This study aims to determine the optimal solid-state fermentation conditions for the removal of zearalenone (ZEN ) from corn gluten feed by Aspergillus niger (A.niger ) FS10.[Method ] With the removal rate of ZEN as the indicator,single-factor experiments and response surface method were employed to optimize the key fermentation parameters (inoculation volume-to-mass ratio,fermentation temperature,fermentation duration,and solid-to-liquid ratio ).Furthermore,changes in mass fractions of key nutritional components in corn gluten feed before and after solid-state fermentation under the optimal conditions were analyzed.[Result ] The optimal fermentation conditions were established as follows:an inoculation volume-to-mass ratio of 120 μL∶1 g,a fermentation temperature …
Advances In The Mechanisms Of The Effects Of Pseudomonas Spp. Proteases On Gelatinization Of Dairy Products And Regulation Strategies, Shengjia Liu, Kairu He, Hui Li, Yongqiang Li, Xinyi Li, Rina Wu, Junrui Wu, Sanjun Zhao
Advances In The Mechanisms Of The Effects Of Pseudomonas Spp. Proteases On Gelatinization Of Dairy Products And Regulation Strategies, Shengjia Liu, Kairu He, Hui Li, Yongqiang Li, Xinyi Li, Rina Wu, Junrui Wu, Sanjun Zhao
Journal of Food Science and Biotechnology
Gelatinization of dairy products has long been a common problem caused by heat-resistant protease contamination.Despite the high-temperature sterilization process,heat-resistant proteases secreted by Pseudomonas spp.can survive under extreme conditions.These enzymes can break down the peptide bonds of proteins in milk,resulting in the bitter taste and gelatinization of milk,which seriously affects the quality and shelf-life of dairy products.In view of the complex gelatinization mechanisms of dairy products and the lack of in-depth investigation,the author systematically outlined the characteristics,enzyme activity detection methods,and influencing factors of Pseudomonas spp.proteases,delved into the mechanisms underpinning the protease-induced gelatinization of dairy products,and summarized the control measures and novel …
Application Potential Of Ellagic Acid In Functional Food, Lu Sun, Yan Dong, Qiming Miao, Jiayuan Wu, Shengquan Mi
Application Potential Of Ellagic Acid In Functional Food, Lu Sun, Yan Dong, Qiming Miao, Jiayuan Wu, Shengquan Mi
Journal of Food Science and Biotechnology
Ellagic acid,a natural polyphenol,exists widely in plants and fruit tissue.It is mainly absorbed in the stomach and small intestine and produces multiple urolithins such as urolithin M 5 and urolithin M 6 under the metabolism of intestinal flora.With antioxidant,anti-inflammatory,anti-tumor,anti-aging,antimicrobial,blood glucose-lowering and other pharmacological effects,ellagic acid have important application and research value in the fields of functional food and medicine.The extraction methods,metabolism mechanisms,and pharmacological effects of ellagic acid and its application in functional food were reviewed.The difficulties in the application of ellagic acid in functional food were elucidated,and the future research focus was put forward.This review aims to provide a theoretical …
Microbial Community Structure And Differential Metabolites Of High-Temperature Daqu And Rice Straw, Dan Xie, Cheng Wu, Jianfeng Hu, Wenyu Zhao, Heou Huang, Junlin Yang, Yuanlin Bi, Diqiang Wang
Microbial Community Structure And Differential Metabolites Of High-Temperature Daqu And Rice Straw, Dan Xie, Cheng Wu, Jianfeng Hu, Wenyu Zhao, Heou Huang, Junlin Yang, Yuanlin Bi, Diqiang Wang
Journal of Food Science and Biotechnology
[Objective ] This study was designed to elucidate the microbial community succession dynamics of rice straw and high-temperature Daqu at distinct stages of fermentation,investigate the associations between differential metabolites and dominant microorganisms,and preliminarily predict the sources and contribution of microorganisms in high-temperature Daqu.[Method ] High-throughput sequencing combined with liquid chromatography-mass spectrometry (LC-MS ) was used to analyze the variation patterns of microbial communities and metabolites during the fermentation of high-temperature Daqu.[Result ] Pantoea and Pseudomonas were the dominant bacterial genera,while the dominant fungal genera were Mrakia and Nigrospora in new rice straw (XC).For mother rice straw (MC),Bacillus and Saccharopolyspora were …
Metagenomic Characterization Of Gut Microbiota In Children With Autism Spectrum Disorder: Microbial Signatures And Modulation By Anti-Inflammatory Diet And Probiotics, Marysol Valencia-Buitrago, Rodrigo Dias Oliveira-Carvalho, Valbert Cardoso, Jessica Triviño-Valencia, Luisa Matilde Salamanca-Duque, Vanessa Martínez-Díaz, Jovanny Zabaleta, Narmer Fernando Galeano-Vanegas, Carlos Andrés Naranjo-Galvis
Metagenomic Characterization Of Gut Microbiota In Children With Autism Spectrum Disorder: Microbial Signatures And Modulation By Anti-Inflammatory Diet And Probiotics, Marysol Valencia-Buitrago, Rodrigo Dias Oliveira-Carvalho, Valbert Cardoso, Jessica Triviño-Valencia, Luisa Matilde Salamanca-Duque, Vanessa Martínez-Díaz, Jovanny Zabaleta, Narmer Fernando Galeano-Vanegas, Carlos Andrés Naranjo-Galvis
School of Medicine Faculty Publications
Background: Autism Spectrum Disorder (ASD) is increasingly associated with alterations in gut microbiota, intestinal permeability, and immune dysregulation. However, integrative studies exploring these mechanisms in Latin American populations are lacking. Objective: To characterize gut microbiota profiles in Colombian children with ASD and evaluate the effects of two microbiota-targeted interventions, an anti-inflammatory diet and a probiotic formulation, on microbial diversity and taxonomic composition. Methods: In a two-phase study, shotgun metagenomic sequencing was performed on fecal samples from 23 children with ASD and 7 typically developing (TD) controls. In the second phase, 17 children with ASD were randomized to receive a 12-week …
Evaluation Of Dietary Additives On Yellowtail Kingfish (Seriola Lalandi) Gut And Skin Health And Disease Resistance Against Photobacterium Damselae Subsp. Damselae, Md Reaz Chaklader, Lindsey Woolley, Chelsea Woods, Frances Stephens, Richard Smullen, Gavin Partridge
Evaluation Of Dietary Additives On Yellowtail Kingfish (Seriola Lalandi) Gut And Skin Health And Disease Resistance Against Photobacterium Damselae Subsp. Damselae, Md Reaz Chaklader, Lindsey Woolley, Chelsea Woods, Frances Stephens, Richard Smullen, Gavin Partridge
Fisheries Research Articles
The present study evaluated the effectiveness of five dietary additives in improving growth performance, gut and skin health and disease resistance against Photobacterium damselae subsp. damselae (Pdd) in yellowtail kingfish (YTK) (Seriola lalandi). The additives were top-coated onto a commercial diet. The five additives evaluated were brewer’s yeast (BY), a yeast-based mannan oligosaccharide (MOS), a polyphenol product, a monoglyceride product and a combination of MOS and a superoxide dismutase (SOD) product. The monoglyceride and polyphenol products were trialled at both a low and high inclusion level. Diets were fed to YTK in triplicate tanks for 55 days. The …
Biophobia And Pet Ownership: Can Having A Pet Mitigate Our Fear And Aversion Towards Nature?, Alexia Barrable
Biophobia And Pet Ownership: Can Having A Pet Mitigate Our Fear And Aversion Towards Nature?, Alexia Barrable
The International Journal of Ecopsychology (IJE)
Biophobia, which we defined as fear, disgust, or aversion toward natural environments or organisms, has received little empirical attention when compared to biophilia, despite its implications for human and planetary wellbeing. This mixed-methods study explores the relationship between pet ownership, biophobia, and nature connectedness among 373 English- speaking adults. Quantitative findings reveal that (M = 26.4) exhibit significantly lower levels of biophobia than non-pet owners (M = 30.1; U = 5179, Z = -2.95, p = .002, R = 0.27), although no significant differences in nature connectedness were found across pet ownership (U = 7033, Z = 0.31, p = …