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A Compartmental Model For Annual Bat Migration, Elena D. Wheatley, Rhianna Yates, Leah Glasser, Christopher Hay-Jahans Nov 2025

A Compartmental Model For Annual Bat Migration, Elena D. Wheatley, Rhianna Yates, Leah Glasser, Christopher Hay-Jahans

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Analyzing Urban Space-Use Of White-Tailed Deer (Odocoileus Virginianus), Szandra A. Péter, Zehidul Hussain, Solena Kronstedt, Amira Roess, Jennifer Mullinax, Travis Gallo, Taylor Anderson Nov 2025

Analyzing Urban Space-Use Of White-Tailed Deer (Odocoileus Virginianus), Szandra A. Péter, Zehidul Hussain, Solena Kronstedt, Amira Roess, Jennifer Mullinax, Travis Gallo, Taylor Anderson

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


A Compartmental Model For Periodic Animal Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans Nov 2025

A Compartmental Model For Periodic Animal Migration, Rhianna Yates, Leah Glasser, Elena Wheatley, Christopher Hay-Jahans

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


A Compartmental Model For Annual Blue Whale Migration, Leah Glasser, Christopher Hay-Jahans, Elena Wheatley, Rhianna Yates Nov 2025

A Compartmental Model For Annual Blue Whale Migration, Leah Glasser, Christopher Hay-Jahans, Elena Wheatley, Rhianna Yates

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Michigan Academician Volume 50, Issue 1 Nov 2025

Michigan Academician Volume 50, Issue 1

Michigan Academician

2025 Michigan Academy Conference abstracts.


Augmented Reality-Assisted E-Module On Temperature Andheat Content (Emarks), Tetri Sabrina, Ika Mustika Sari, Dedi Sasmita Nov 2025

Augmented Reality-Assisted E-Module On Temperature Andheat Content (Emarks), Tetri Sabrina, Ika Mustika Sari, Dedi Sasmita

Jurnal Pendidikan Sains

Temperature and heat content (calor) material in physics often involves concepts and phenomena that are difficult to observe directly or are abstract (such as energy transfer, particle movement, and changes in state). EMARKS (AR-based E-modules) are important because Augmented Reality (AR) allows the visualization of these abstract concepts in the form of interactive 3D models in the user's real environment. This helps students understand the concepts more concretely and easily. The development of E-modules is an innovation in learning media that is relevant to the demands of the digital era and the needs of modern students. The use of advanced …


Red Snapper (Lutjanus Campechanus) Neurocranium, Sarah Hendricks, Morgan Indyk, David W. Kerstetter Nov 2025

Red Snapper (Lutjanus Campechanus) Neurocranium, Sarah Hendricks, Morgan Indyk, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Mechanisms Of Antibody-Mediated Protection In Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Samantha Mackin Nov 2025

Mechanisms Of Antibody-Mediated Protection In Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Samantha Mackin

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Mechanisms of Antibody-Mediated Protection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Samantha Rae Mackin Doctor of Philosophy in Biology and Biomedical Sciences Immunology Washington University in St. Louis, 2025 Professor Michael S. Diamond, Chair Coronaviruses (CoVs) are enveloped, non-segmented, positive-sense RNA viruses belonging to the Coronaviridae family. The subfamily Coronavirinae includes four genera: alpha-, beta-, gamma-, and deltacoronaviruses. While gamma- and deltacoronaviruses primarily circulate in wild or domestic birds and have shown the potential for cross-species transmission, alpha- and betacoronaviruses mainly infect mammals, resulting in respiratory illnesses that can be mild or severe. Over …


Program Transition Success: A Practical Guide For Educators Moving Sbae Programs, Evey Choat Nov 2025

Program Transition Success: A Practical Guide For Educators Moving Sbae Programs, Evey Choat

Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research

What tools, strategies, and support systems can help agriculture educators navigate leadership transitions and sustain program success when moving between schools or communities? Teacher mobility and leadership transitions within School-Based Agricultural Education (SBAE) present unique challenges to program continuity, community relations, and professional sustainability. Unlike other subject areas, SBAE teachers often manage multifaceted responsibilities—as classroom instructors, FFA advisors, and community liaisons—making transitions between programs especially complex. This project addresses the lack of structured support for educators navigating these transitions by developing a Program Transition Guide specifically tailored to the needs of agricultural educators in Nebraska.

Guided by Transformational Leadership Theory …


Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva Nov 2025

Menin Inhibitor Ds-1594b Drives Differentiation And Induces Synergistic Lethality In Combination With Venetoclax In Acute Myeloid Leukemia Cells With Rearranged Mixed-Lineage Leukemia And Mutated Nucleophosmin-1, Valerio Ciaurro, Vassilena Sharlandjieva, Anna Skwarska, Catherine Chahrour, Natalia Baran, Zhihong Zeng, Cassandra Ramage, Naval Daver, Bing Z Carter, Sovira Chaundhry, Palaniraja Thandapani, Maria Paola Martelli, Thomas A Milne, Marina Konopleva

Faculty, Staff and Student Publications

Mixed-lineage leukemia (MLL) rearrangements and Nucleophosmin-1 (NPM1) mutations are associated with acute leukemias whose pathogenesis is critically influenced by protein-protein interactions between menin and MLL. We hypothesized that targeting the menin-MLL interaction using DS-1594b and blocking the antiapoptotic BCL-2 protein using venetoclax may promote differentiation and enhance eradication of MLL-rearranged and NPM1-mutated leukemias models. We treated acute myeloid leukemia (AML) cell lines with MLL rearrangements, NPM1 mutations, other leukemias and primary samples from AML patients with venetoclax alone, DS- 1594b alone, and their combination. We measured proliferation, viability, apoptosis, and differentiation using a variety of cellular assays, Western blotting, and …


The Head-Direction Signal Is Generated From Two Types Of Head Direction Cells In Brainstem Nuclei, Ryan M. Yoder Nov 2025

The Head-Direction Signal Is Generated From Two Types Of Head Direction Cells In Brainstem Nuclei, Ryan M. Yoder

Psychology

Head direction (HD) cells discharge based on an animal's directional heading. Computational models propose that a ring-attractor network across the connections between the lateral mammillary (LMN) and dorsal tegmental nuclei (DTN) underlies the signal's generation. These models contain neurons that encode either HD or angular head velocity (AHV), but also require cells that are sensitive to both parameters conjunctively (HD + AHV). Here we identify both types of HD cells in the LMN and DTN of female rats, with one population sensitive to AHV (both symmetric and asymmetric), and the other population insensitive to AHV. Notably, many HD + AHV …


How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo Nov 2025

How Plants Defy Gravity, Olivia Y. Kim, Agatha Shaikhutdinova, Joshua Lee, Reece Sit, Daniel Yang, Aliyah Shams, Kathryn Choi, Esther Yoo

STEM for Success Showcase

This educational short book, written by students, uses creative descriptions to make biology and chemistry concepts engaging and easy to understand.


Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, William James Antonisamy, Vasanthi Jayaraman, Zahoor A Shah, Valeria Vásquez, Julio F Cordero-Morales Nov 2025

Cofilin Inhibition Ameliorates Piezo2 And Ampa Dysfunction In A Mouse Model Of Angelman Syndrome, Luis O Romero, Manisha Bade, Elisa Carrillo, Sonia Paz-López, Syed A M Hasan, William James Antonisamy, Vasanthi Jayaraman, Zahoor A Shah, Valeria Vásquez, Julio F Cordero-Morales

Faculty, Staff and Student Publications

Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported in dorsal root ganglia (DRG) neurons, along with impaired mechanosensitive ion channel activity. Currently, there are no pharmacological targets to prevent the decrease of F-actin in AS. Here, we utilize a first-in-class selective cofilin inhibitor (SZ-3) to restore PIEZO2 function in DRG neurons and glutamate-evoked currents in hippocampal neurons from AS mice. Using atomic force microscopy, we demonstrate that inhibiting cofilin, an actin-severing protein, with SZ-3 increases cellular stiffness by stabilizing the actin …


A Multi-Faceted Study Of Antibiotic-Resistant, Opportunistic Pathogens In Wastewater And Environmental Water, Jeanette Calarco Nov 2025

A Multi-Faceted Study Of Antibiotic-Resistant, Opportunistic Pathogens In Wastewater And Environmental Water, Jeanette Calarco

USF Tampa Graduate Theses and Dissertations

More than 2.8 million infections due to antibiotic-resistant bacteria occur annually in the United States, and more than 35,000 people die as a result. Domestic wastewater (sewage), which contains antibiotic-resistant bacteria and antibiotic resistance genes, is collected at treatment plants for removal of contaminants, e.g. pathogenic microorganisms and nutrients. While wastewater treatment is designed to remove antibiotic-resistant bacteria and other microorganisms through treatment and disinfection, some bacteria may escape treatment. Treated wastewater effluent is generally discharged into surface waters; however, some fraction of the effluent may be used as recycled water. Compromised wastewater collection infrastructure and sewage spills can disseminate …


Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore Nov 2025

Evaluating Soil Responses To Three Different Tillage Practices, Robert L. Burchett, Cordale L. Straub Senior, Logan D. Renfrow Sophomore

Scholars Week

Evaluating Soil Responses to Three Different Tillage Practices

Luke Burchett, Logan Renfrow, and Cordale Straub

Mentor: Dr. Iin Handayani Ph.D

Hutson School of Agriculture, Murray State University, Kentucky, USA

ABSTRACT

Tillage systems can greatly affect soil health by changing its structure, chemistry, and biological activity. This study examined how soil organic carbon (SOC), soil pH, soil moisture, soil organic matter (SOM) responds under three tillage systems: no-till, biannual tillage, and conventional tillage. Soil samples were taken from a 1–7.6 cm depth during September 2025 across three locations. The no-till site was located in Caldwell County, Kentucky, on an irrigated double-crop …


Shaping The Soil: A Comparison Of Equine, Bovine, And Ungrazed Hay Fields, Brody Ellis Higgs, Taylor Madison Wynn, Scottie Craig Berry Nov 2025

Shaping The Soil: A Comparison Of Equine, Bovine, And Ungrazed Hay Fields, Brody Ellis Higgs, Taylor Madison Wynn, Scottie Craig Berry

Scholars Week

Shaping the Soil: A Comparison of Equine, Bovine, and Ungrazed Hay Fields

Brody Higgs, Taylor Wynn, and Scottie Berry

Mentor: Dr. Iin. P. Handayani, PhD.

Hutson School of Agriculture, Murray State University, Murray, Kentucky, USA

ABSTRACT

Kentucky raises grazing species for multiple reasons, including food, recreation, and show. The most common of them are equine and bovine. These animals graze many acres across the state of Kentucky and impact soil properties in their pastures. This study was conducted on three pasturelands across Caldwell and Calloway counties in Kentucky. The pastures consisted of a cow pasture, a horse pasture, and a …


A Fine Lady And Excellent Field Botanist: Sister Remberta Westkaemper, O.S.B., Stephen G. Saupe Nov 2025

A Fine Lady And Excellent Field Botanist: Sister Remberta Westkaemper, O.S.B., Stephen G. Saupe

Biology Faculty Publications

This report provides a brief biography of Sister Remberta and an overview of her botanical activities


Red Snapper (Lutjanus Campechanus) Neurocranium, Riley B. Glogowski, David W. Kerstetter Nov 2025

Red Snapper (Lutjanus Campechanus) Neurocranium, Riley B. Glogowski, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Pregnancy Outcomes In Women With Heritable Thoracic Aortic Disease: Data From The Eorp Esc Registry Of Pregnancy And Cardiac Disease (Ropac) Iii, Puck N J Peters, Johanna A Van Der Zande, Julie De Backer, Guillaume Jondeau, Osama Ahmad, Marjorie Richardson, Francesca M Comoglio, Heleen Van Der Zwaan, Siddharth K Prakash, Christina Christersson, Karishma P Ramlakhan, Roger Hall, Mark R Johnson, Jolien W Roos-Hesselink, Ropac Investigators Nov 2025

Pregnancy Outcomes In Women With Heritable Thoracic Aortic Disease: Data From The Eorp Esc Registry Of Pregnancy And Cardiac Disease (Ropac) Iii, Puck N J Peters, Johanna A Van Der Zande, Julie De Backer, Guillaume Jondeau, Osama Ahmad, Marjorie Richardson, Francesca M Comoglio, Heleen Van Der Zwaan, Siddharth K Prakash, Christina Christersson, Karishma P Ramlakhan, Roger Hall, Mark R Johnson, Jolien W Roos-Hesselink, Ropac Investigators

Faculty, Staff and Student Publications

Aims: The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient management and care.

Methods and results: The Registry of Pregnancy and Cardiac disease (ROPAC) III is a prospective global registry including pregnant women with known aortic pathology between 2018 and 2023. Cardiac, obstetric and fetal outcomes, beta-blocker use, and the impact of breastfeeding were investigated. Additionally, changes in aortic diameters were assessed. In total, 176 pregnancies in 170 women (mean age 32 years, …


Effects Of Combining Traditional East Asian And Conventional Western Medicine On Acute Stroke Outcomes, Dong-Seok Gwak, Jong-Sik Lee, Dawid Schellingerhout, Jinyong Chung, Hyerin Oh, Sang-Wuk Jeong, Ji Sung Lee, Hee-Joon Bae, Mikyung Kim, Dong-Jun Choi, Dong-Eog Kim Nov 2025

Effects Of Combining Traditional East Asian And Conventional Western Medicine On Acute Stroke Outcomes, Dong-Seok Gwak, Jong-Sik Lee, Dawid Schellingerhout, Jinyong Chung, Hyerin Oh, Sang-Wuk Jeong, Ji Sung Lee, Hee-Joon Bae, Mikyung Kim, Dong-Jun Choi, Dong-Eog Kim

Faculty, Staff and Student Publications

Background: Traditional East Asian medicine (TM) is widely used in Korea and other East Asian countries. However, the effects of TM treatment on acute ischemic stroke (AIS) outcomes remain unclear, as previous studies lacked a sufficient sample size, a consecutive series design, or a prospective outcome capture approach. We aimed to investigate whether combining TM with conventional Western medicine (CM) treatments (C+TM) leads to better outcomes after AIS, relative to CM treatment alone.

Methods: We retrospectively analyzed 2157 consecutive patients with AIS from a prospectively collected registry (2011-2021) at our center and compared the CM and C+TM groups in terms …


Improving Coral Restoration Outcomes Through Novel Molecular Applications, Matthew H. Gamache Nov 2025

Improving Coral Restoration Outcomes Through Novel Molecular Applications, Matthew H. Gamache

USF Tampa Graduate Theses and Dissertations

Coral reef ecosystems are declining globally from numerous stressors, including localized pollution, disease, and marine heatwaves induced by climate change. To preserve these ecosystems, it is critical to identify corals that can withstand stressors—primarily future marine heatwaves—and prioritize them for coral restoration efforts until these stressors are mitigated. Coral responses to thermal stress can be influenced by several partners, including mutualistic microalgae and a vast prokaryotic community. Here, I use advanced molecular techniques to examine which partners (coral host, algal symbiont, and microbial communities) are associated with coral health, how they contribute to holobiont physiology, and their potential to increase …


Serum Response Factor Is Essential For Endometrial Function And Prevention Of Inflammatory Fibrosis, Ryan M Marquardt, Sara A Grimm, San-Pin Wu, Peter F Lais, Shu-Yun Li, Xin Xu, Erin Smithberger, David Cunefare, Charan Ganta, David Olson, Eunhee M Jeong, Jae-Wook Jeong, Bruce A Lessey, John P Lydon, Francesco J Demayo Nov 2025

Serum Response Factor Is Essential For Endometrial Function And Prevention Of Inflammatory Fibrosis, Ryan M Marquardt, Sara A Grimm, San-Pin Wu, Peter F Lais, Shu-Yun Li, Xin Xu, Erin Smithberger, David Cunefare, Charan Ganta, David Olson, Eunhee M Jeong, Jae-Wook Jeong, Bruce A Lessey, John P Lydon, Francesco J Demayo

Faculty, Staff and Students Publications

Pregnancy requires a supportive uterine environment facilitated by steroid hormone–regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. Serum response factor (SRF) is a widely expressed transcription factor essential for mesenchymal cell growth and differentiation with noted roles in hormonal regulation of muscle tissues but little characterization in reproductive organs. Here, we reveal that endometrial SRF is dysregulated in human endometriosis and is critical for female reproductive success in mice through regulation of endometrial stromal and epithelial cells. Immunohistochemical analysis identified decreased endometrial SRF expression in infertile endometriosis patient tissues. RNAi-based SRF knockdown in human …


Deforestation Affecting Developing Nations, Nicole Villa Nov 2025

Deforestation Affecting Developing Nations, Nicole Villa

Sustainability Conference

Deforestation continues to be a growing problem around the globe, while it is affecting wildlife what can be overlooked is the challenges it’s creating for the livelihood of nations. This goes beyond losing the biodiversity of our ecosystems but social consequences with the scarcity of water in Malawi, rise in health risks in Democratic Republic of Congo and negative effects of agricultural expansion in Belize. Overall social conflict in these areas that are suffering to grow. Furthermore, I aim to cover the major challenges previously mentioned followed by counteracts of deforestation including action plan in Brazil, efforts of other countries …


Assessing Antimicrobial Properties Of Plant-Derived Ellagic Acid Supplements, Noah S. Schuhmann, Andrew Mclaughlin, Julian Barrera Nov 2025

Assessing Antimicrobial Properties Of Plant-Derived Ellagic Acid Supplements, Noah S. Schuhmann, Andrew Mclaughlin, Julian Barrera

Humboldt Journal of Microbiology

Bacteria present in the human gut microbiota are affected by compounds with antimicrobial properties. Phenolic compounds extracted from plants have been shown to exhibit significant antimicrobial capacity at certain concentrations, which makes them an area of interest to researchers. Ellagic acid is one such phenolic compound, present in nuts and berries that many people consume on a regular basis. Supplements containing concentrated ellagic acid provide an additional source for the compound. It is known that, in the body, ellagic acid is metabolized into urolithins, which contribute to health through their anticancer and anti-inflammatory qualities. In this study, we investigated the …


Growth Trends In Abundance And Diversity Of Synthetic Microbial Communities Over Varying Thermal Conditions, Mariska M. Kessler, Jocelyn Wolfinger, Destiny S. Alcaraz Nov 2025

Growth Trends In Abundance And Diversity Of Synthetic Microbial Communities Over Varying Thermal Conditions, Mariska M. Kessler, Jocelyn Wolfinger, Destiny S. Alcaraz

Humboldt Journal of Microbiology

Microorganisms create various communities that act as the foundation of ecosystems. Abiotic factors such as temperature variability and environmental fluctuations are known to produce shifts in the abundance and diversity of microbial communities, but our current understanding is limited. In this study, we aimed to address this gap by observing abundance and diversity growth patterns under different temperature conditions within individual species and communities. Samples of 4 isolates and 4 artificial communities were grown at constant and fluctuating temperatures. Results found that the isolate samples had the highest abundance under constant high temperatures, whereas the community samples had the highest …


Elucidating The Relationship Between Water Quality And Antibiotic Resistance Of Rainwater Microbes Across Western Humboldt County, Theo P. Murphy, Eve Wendley, Justice Laskowski, Tyler Paredes Nov 2025

Elucidating The Relationship Between Water Quality And Antibiotic Resistance Of Rainwater Microbes Across Western Humboldt County, Theo P. Murphy, Eve Wendley, Justice Laskowski, Tyler Paredes

Humboldt Journal of Microbiology

Limited studies have been conducted regarding the fecal contamination and microbial dispersal through rainwater, with no known studies investigating the potential connection between antibiotic resistant microbes and water quality in rainwater. This study seeks to identify the presence of a correlation between water quality and incidence of antibiotic resistance in rainwater microbes. We hypothesize that there will be a correlation between these two variables. We additionally anticipate a high incidence of fecal contamination across rural and urban collection sites alike, with fecal contamination being more prevalent in rural areas than urban locals. To determine water quality, we measured the concentration …


Uav Remote Sensing For Assessment Of Conservative Management Practices In Maize-Soybean Cropping System, Aakriti Poudel Nov 2025

Uav Remote Sensing For Assessment Of Conservative Management Practices In Maize-Soybean Cropping System, Aakriti Poudel

LSU Master's Theses

Sustainable agriculture practices promote cover cropping, which enhances nutrient management and impacts subsequent crop productivity in field crop rotations. Precision agriculture technology, particularly Unmanned Aerial Vehicle (UAV) remote sensing, enables a detailed evaluation of crop management. The studies were conducted in a maize-soybean rotation system with winter cover cropping and fallow management. The maize experiment investigated the effect of nitrogen application rates and cover cropping, using UAV-derived Normalized Difference Red-Edge (NDRE) to monitor crop performance. NDRE effectively captured the N response and the effect of cover cropping across growth stages, particularly during mid-season (55-81 DAP), where it showed a strong …


Examining Private Landowner And Stakeholder Attitudes, Perceptions, And Knowledge Of Prescribed Fire In Louisiana, Chloe E. Crawford Nov 2025

Examining Private Landowner And Stakeholder Attitudes, Perceptions, And Knowledge Of Prescribed Fire In Louisiana, Chloe E. Crawford

LSU Master's Theses

Periodic fire was a primary driver of ecosystems across the Southeastern United States for millennia; however, fire suppression policies have become pervasive in the United States and led to increased fuel loads in forests as well as reduced biodiversity and reduced disease resilience. Prescribed fire presents a risk mitigation strategy and land management tool whereby practitioners can apply fire to the landscape in a controlled manner, thus reaping the benefits of fire while minimizing the risks associated with fire. Land in Louisiana is primarily privately managed and owned, so state-level conservation goals cannot be met without private landowner participation. As …


Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions, Shilpa Sharma, Xiaoxia Wen, Jianbo Wang, Beibei Huang, Denise A Hernandez, Cong-Dat Pham, Zhiwen Liu, Susanne Je-Han Lin, Aiko Yamaguchi, Dimitra K Georgiou, Ryan P Coll, H Charles Manning Nov 2025

Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions, Shilpa Sharma, Xiaoxia Wen, Jianbo Wang, Beibei Huang, Denise A Hernandez, Cong-Dat Pham, Zhiwen Liu, Susanne Je-Han Lin, Aiko Yamaguchi, Dimitra K Georgiou, Ryan P Coll, H Charles Manning

Faculty, Staff and Student Publications

Purpose: Because surgery is the only potential cure for pancreatic cancer, high-risk premalignant pancreatic lesions often evade detection by palpation or white-light visualization, increasing the risk of recurrence. We asked whether near-infrared fluorescence imaging of tumor-associated inflammation could identify high-risk premalignant lesions, leveraging the tumor microenvironment as a sentinel of local disease and, thus, enhance surgery outcomes.

Experimental design: Fluorescence-guided surgery was performed on genetically engineered mice [Ptf1a-Cre; LSL-KrasG12D/+; Smad4flox/flox (KSC)] at discrete stages of disease progression, histologically confirmed high-risk, premalignant lesions in postnatal mice to locally advanced pancreatic tumors in adults, using the imaging agent V-1520, a translocator protein …


Starting An Equine-Assisted Services Program, Makenna L. Pahlke Nov 2025

Starting An Equine-Assisted Services Program, Makenna L. Pahlke

All Current Publications

Starting an equine-assisted services (EAS) program requires more than just access to horses and a passion for helping others. This fact sheet outlines the key considerations for communities and individuals interested in developing safe, sustainable, and impactful equine-assisted programs.