Digital Commons Network^™

6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar

Indian Journal of Research in Homoeopathy

Background: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: …

A New Dioecious Bush Tomato, Solanum Nectarifolium (Solanaceae), From The Northern Tanami Desert, Northern Territory, Australia, With Reassessment Of S. Ossicruentum And A Change In The Circumscription Of S. Dioicum, Christopher T. Martine, Kym Brennan, Jason T. Cantley, Aiden Webb, Geoffrey Newton

Faculty Journal Articles

A new species of functionally dioecious bush tomato from the “Solanum dioicum + S. echinatum group” of Solanum subgenus Leptostemonum is described. Solanum nectarifolium Martine & Brennan, sp. nov., is a member of the taxonomically challenging Solanum dioicum W.Fitzg. species complex in Australia and differs from other species in the group by the presence of prominent and conspicuous extrafloral nectaries on the abaxial leaf surfaces, a tinge of purple on the new growth and young fruiting calyces, and curved prickles on young stems. Although fairly well represented in herbarium collections, this new taxon has historically been treated as a …

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …

Batf2 Is A Glutamine-Responsive Tumour Suppressor Required For Type-I Interferon-Dependent Anti-Tumour Immunity, Wang Gong, Hülya F Taner, Yuesong Wu, Yumin He, Xingwu Zhou, Zaiye Li, Xin Hu, Charisse Ursin, Kala Chand Debnath, Kohei Okuyama, Qiang Hu, Christopher R Donnelly, Felipe Nör, Chamila D Perera, Emily Bellile, Arash Yunesi, Zhiqian Zhai, Mei Zhao, Wanqing Cheng, Zackary R Fitzsimonds, Luke Broses, Jiaqian Li, Shadmehr Demehri, Deepak Nagrath, Gregory T Wolf, Andrew G Sikora, Yanbao Yu, Haitao Wen, Lei Wei, Steven B Chinn, Jeffrey N Myers, Shizuo Akira, Yuying Xie, James J Moon, Yu Leo Lei

Faculty, Staff and Student Publications

Recent evidence highlights the significance of a new type of tumour suppressors, which are not frequently mutated but inhibited by metabolic cues in cancers. Here, we identify BATF2 as a tumour suppressor whose expression is epigenetically silenced by glutamine in Head and Neck Squamous Cell Carcinomas (HNSCC). BATF2 correlates with type-I interferon and Th1 signatures in human HNSCC, with correlation coefficients even stronger than those of the positive control, STING. The phosphorylation of BATF2 at serine 227 promotes the oligomerization of STING. BATF2 deficiency or high glutamine levels result in higher oxygen consumption rates and metabolic profiles unfavorable for …

Short- Term Effects Of Cypermethrin Pesticide On Nutrient Levels And Microbial Communities In Tropical Soil Of Uganda, Mama N. Simon

Tanzania Journal of Science

Cypermethrin is an insecticide widely used by farmers in Uganda to control pests and diseases. The widespread use leads to biomagnification, affecting humans and the ecosystem. This study examined the short-term effects of cypermethrin on soil macronutrients (N, P, K), meso-nutrients (Ca, Mg), and microbial communities (bacteria, fungi, and actinomycetes) in tropical Ugandan soils. Soil samples treated with cypermethrin and control were collected and analysed using standard methods of flame photometry for potassium (K), atomic absorption spectroscopy for calcium and magnesium, Wet-acid oxidation for nitrogen and phosphorus, and standard plate count techniques for microbial populations. The study used a Randomized …

Food Safety Concerns: A Review On Pathogenic Microbes Associated With Common Edible Insects, Anitha Philbert

Tanzania Journal of Science

This review explored the pathogenic microbes associated with common edible insects. With rising human populations and fluctuating food supplies, edible insects offer a rich source of protein, vitamins, and minerals and are culturally accepted in many regions. Despite their nutritional benefits, knowledge on microbial hazards associated with edible insects is fragmented. The review focuses on commonly consumed species, including Tenebrio molitor, Zophobas morio, Acheta domesticus, Gryllus bimaculatus, Locusta migratoria, Ruspolia differens, Bombix mori, Bunaea alcinoe, and Oryctes monoceros. A total of 43 pathogenic bacteria and 20 pathogenic fungi linked to these edible insect species were identified. The most frequently reported …

Comparative Effects Of Gamma Irradiation And Chemical Treatments On Superficial Scald And Quality Of ‘Granny Smith’ Apples, Francisco E. Loayza, Michelle Tu, Hagop S. Atamian, Anuradha Prakash

Food Science Faculty Articles and Research

Fresh produce is highly perishable, necessitating various postharvest treatments to minimize quality loss, extend shelf-life, and facilitate international trade. This study investigated the potential of a single low-dose gamma irradiation treatment as an alternative to commercially used chemical treatments for protecting ‘Granny Smith’ apples against insect pests and postharvest disorders. ‘Granny Smith’ apples harvested in 2019 and 2020 were treated with gamma irradiation at doses of 240 or 860 Gray (Gy) or with commercial chemical applications of 1-methylcyclopropene (1-MCP), diphenylamine (DPA), or methyl bromide (MeBr). The impact on fruit quality, physiology, and the development of postharvest disorders was evaluated after …

Pressure Field Estimation From 2d-Piv Measurements: A Case Study Of Fish Suction-Feeding, Jensine C. Coggin, Duvall Dickerson-Evans, Erin E. Hackett, Roi Gurka

Physics and Engineering Science

Particle image velocimetry (PIV) flow measurements are common practice in laboratory settings in a wide variety of fields involving fluid dynamics, including biology, physics, engineering, and medicine. Dynamic fluid pressure is a notoriously difficult property to measure non-intrusively, yet its variation is a driving flow force and critical to model correctly. Techniques have been developed to estimate the pressure from velocity and velocity gradient measurements. Here, we highlight a novel application of boundary conditions when applying such pressure estimation techniques based on two-dimensional PIV data; the novel method is especially relevant to problems with complex boundary conditions. As such, it …

Mechanical Improvements And Control Implementation On A Biomimetic Quadruped Model, Matthew Jack Lutz

Dissertations and Theses

Robotic development started billions of years after earth first began biological prototyping. While the evolutionary process in animals is quite different from robotic prototyping, it still remains no surprise that animals remain more agile, more efficient, and more adaptable than even the most advanced engineered robots to date, simply due to the sheer length of their improvement process. While bridging this improvement gap between deficits in robots and the abilities of animals is difficult, a specific subfield of robotics engineering has attempted to do so using biomimetic robotics. At Portland State, the Agile and Adaptive Robotics Lab (AARL) studies these …

Composite Flours For Sustainable Food Systems: Integrating Nutritional, Environmental, And Climate Resilience Strategies, Rashmi H. Poojara, Soumya P S, Alvina Rose, Niva Somarajan

Journal of Environmental Science and Sustainable Development

Composite flour blends prepared from cereals, millets, tubers, legumes, and vegetables have gained increasing attention due to their potential to enhance nutritional quality, improve functional properties, and support sustainable food systems. Previous studies have largely focused on individual nutritional or functional attributes, with limited integration of environmental and health perspectives. This review aimed to systematically analyze how composite flours simultaneously influence nutritional quality, functional performance, health relevance, and environmental sustainability within a unified analytical framework. A systematic literature review was conducted following PRISMA guidelines. Peer-reviewed studies published between 2014 and 2025 were retrieved from PubMed, Scopus, Web of Science, and …

Folding Architecture “Origami Art-Inspired” Applicability To Sustainable Architecture- Biomuseo As A Case Study, Vitta A. Ibrahim

Mansoura Engineering Journal

The growing need for sustainable architectural solutions in the contemporary era underscores the necessity for interactive architectural applications that can adapt to changing requirements. In architecture, folding systems refer to three-dimensional, foldable structural forms that create unique spatial configurations and possess a wide range of capabilities. Drawing inspiration from origami techniques, this study emphasizes the role of folding systems in generating innovative spatial designs. The research problem arises from the fact that the built environment is a significant contributor to greenhouse gas emissions and energy consumption, necessitating the implementation of smart solutions. The goal of this study is to identify …

Comparative Transcriptomics Reveals Novel And Differential Long-Noncoding Rna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang

Food and Animal Sciences Faculty Research

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to the global swine industry. Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of antiviral immunity, but their roles in porcine alveolar macrophages (PAMs)—the primary target of PRRSV—remain poorly characterized. This study presents a genome-wide analysis of lncRNA expression in PAMs stimulated with a PRRS modified live virus (MLV) vaccine and two type I interferons, IFN-α1 and IFN-ω5. Whole-transcriptome sequencing identified over 2000 differentially expressed lncRNAs, with IFN-ω5 inducing the most extensive transcriptional reprogramming. Weighted gene co-expression network analysis (WGCNA) revealed interferon-specific lncRNA-mRNA modules, and functional enrichment showed …

Seroprevalence And Risk Determinants Of Toxoplasma Gondii Infection In Pregnant Women In Pakistan: A Cross-Sectional Study, Tajul Haram, Kamran Khan

Journal of Bioresource Management

Toxoplasma gondii is a globally important zoonotic parasite, and maternal infection during pregnancy may cause miscarriage, congenital anomalies, or severe neonatal complications. This cross-sectional study was conducted among 367 pregnant women attending hospitals in District Dir Upper, Khyber Pakhtunkhwa, Pakistan, to evaluate the seroprevalence of T. gondii and associated risk factors. Blood samples were analyzed using Immunochromatographic Test (ICT) for initial screening, and positive cases were confirmed by Enzyme-Linked Immunosorbent Assay (ELISA). Overall, 34.6 % (127/367) of women tested positive. While no significant differences were observed across age groups, gestational trimesters, or abortion history, higher prevalence was noted in women …

Isolation And Molecular Characterization Of Shiga Toxin Producing Genes Stx1and Stx2 From The Captive Migratory Birds Of Lahore, Romana Zulfiqar, Hamid Ullah, Bushra Nisar Khan, Muhammad Habib Ur Rehman, Hoor Ul Ain, Alishba Zaheer, Samrah Hussain, Aazba Naeem

Journal of Bioresource Management

A total of 240 cloacal and fecal swabs were collected from 25 avian species, including ducks, swans, geese, pheasants, guinea fowl, parrots, cranes, and crows. Samples were cultured on Sorbitol MacConkey Agar, and presumptive Escherichia coli isolates were confirmed using morphological, biochemical, and molecular methods. Shiga toxin–producing E. coli (STEC) was identified through PCR detection of stx1 and stx2 genes, followed by sequencing. Antibiotic susceptibility testing was performed using the Kirby–Bauer disc diffusion method against streptomycin, ceftriaxone, ciprofloxacin, azithromycin, and tetracycline. Only four STEC isolates were recovered, resulting in an overall prevalence of 1.66 % (4/240). Positive cases were detected …

The Assessment Of Soil Physico-Chemistry And Uptake Of Heavy Metals In Lumbricus Terrestris, Shahzad Anjum, Sidra Kanwal, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Imran

Journal of Bioresource Management

Earthworms are considered ecosystem engineers, playing an essential role in soil fertility. Heavy metals are supposed to remain linked to soil for a very long time and can bio-accumulate swiftly in soil microbes, posing a severe threat to the environment. The current study was designed to investigate the bio-accumulation of heavy metals in Lumbricus terrestris and the impact of soil pH and texture on earthworm morphology and densities near industrial areas of the district of Okara, Punjab, Pakistan. The samples were collected from the locations of different industries using the quadrate method and analyzed for heavy metal accumulation by using …

Enhancing Topical Delivery Of N-Acetylcysteine And Collagen Via A Novel Electrospun Collagen/Pmma Nanofibrous Mats As Facial Mask Development: Nanofibers Optimization And In Vitro Experiments, Samar A. Salim, Galala University, King Faisal University, Badr University, National Research Centre, City Of Scientific Research And Technological Applications (Srta-City),, Badr University

Nanotechnology Research Centre

This study endeavours to craft a potent topical facial mask using electrospun nanofibers. The nanofibers were carefully fabricated based on loading of N-acetylcysteine (NAC) onto electrospun marine collagen (MC), and poly (methyl methacrylate) (PMMA) nanofibers. Through precise adjustments of electrospinning parameters, a uniform array of nanoscale fibres with a smooth surface was achieved. The morphology and chemical structure configuration of nanofibers (NFs) were examined using SEM, FTIR, and XRD analyses. Furthermore, the cytotoxic impact was assessed on a human normal fibroblast cell line (BJ1), while protein levels were gauged using the Bradford dye-binding assay (Coomassie assay). Also, the antioxidant potential …

Hepatocyte-Specific Lrp1 Silencing Exacerbates Brain Amyloidosis Without Compensatory Ldl Receptor Family Involvement, Brian Carson, Josephine Chu, Devaraj V. Chandrashekar, Jerome Garcia, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

LDL receptor related protein 1 (LRP1) is a major hepatic receptor involved in lipoprotein metabolism, protease degradation, transmembrane receptor modulation, and clearance of excess protein, such as Aβ. Decreased expression of LRP1 due to liver injury can impair receptor-mediated clearance, increasing Aβ availability in the periphery. We investigated the effects of hepato-specific silencing of LRP1 on Aβ deposition in the brain. Additionally, other LDL family members (LRP5, LRP6, and LDLR) that may participate in Aβ clearance were monitored in the liver to ensure non-compensatory effects of LRP1 silencing.

Method

4-month-old male double transgenic (APP/PS1) AD mice were injected with …

Exploring Bacterial Diversity In Seagrass Meadow Of Thalassia Hemprichii And Syringodium Isoetifolium From Tanzania’S Coast, Lucy D. Mbusi, Thomas J. Lyimo, Sylvester L. Lyantagaye

Tanzania Journal of Science

Seagrasses are highly productive coastal ecosystems that harbor diverse bacterial communities, including both culturable and unculturable taxa. These bacteria play vital roles in ecological, biogeochemical, and biotechnological processes. In this study, a metagenomic approach using Pacific Biosciences next-generation sequencing was employed to investigate bacterial diversity associated with Thalassia hemprichii and Syringodium isoetifolium collected from the Mjimwema coast, Dar es Salaam, Tanzania. Results revealed that T. hemprichii supported greater bacterial species diversity (117 OTUs) compared to S. isoetifolium (109 OTUs). Among plant compartments, roots harbored the highest diversity, followed by rhizosphere sediment and leaves. The phylum Proteobacteria dominated across all samples …

Effects Of Replacing Antibiotics With Bacillus-Based Probiotics In The Diet Of Lactating Sows On Reproductive Performance, Feed Intake, Serum Immunoglobulin Levels, Milk Production, Oxidative Stress Markers, Fecal Short-Chain Fatty Acids, And Piglet Growth Performance, Chutikan Srisang, Tip-Apa Akkhaphan, Preechaphon Taechamaeteekul, Junpen Suwimonteerabutr, Rafa Boonprakob, Suparlark Nuntawan Na Ayudhya Dr, Lea Hübertz Birch Hansen Dr, Padet Tummaruk

The Thai Journal of Veterinary Medicine

This clinical trial investigated the effects of adding a Bacillus-based probiotic to the lactation diet of sows (without in-feed antibiotics) on maternal and piglet outcomes. A total of 109 Landrace × Yorkshire sows (parity 1–7) were assigned to either a control group (n = 61) or a treatment group (n = 48) receiving Bacillus subtilis – 541 and Bacillus amyloliquefaciens – 516. Piglets in the treatment group also received the probiotics via creep feed from day 3 until weaning. Blood samples were collected within 12 h after farrowing to assess serum immunoglobulins (IgG, IgA, and IgM) and malondialdehyde (MDA) …

The Mitochondria Is The Source Of Hepatic Amyloid Precursor Protein And Peripheral Amyloid Beta: Implications Of Alcohol-Induced Liver Steatosis In Alzheimer's Disease, Josephine Chu, Ross A. Steinberg, Brian Carson, Devaraj Venkatapura Chandrashekar, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

Alcohol-induced liver injury occurs in the pericentral region of the liver and can induce mitochondrial remodeling and exacerbate Alzheimer's Disease (AD) progression. Subpopulations of mitochondria: general mitochondria (GM), peridroplet mitochondria (PDM) and endoplasmic reticulum(ER)-bound mitochondria (ERM) maintain cellular homeostasis via energy synthesis, lipid homeostasis, and regulation of intracellular calcium. Hepatic amyloid precursor protein (APP) is a source of peripheral amyloid beta (aB) and affects AD pathology in the brain. Understanding the localization and expression of hepatic APP in mitochondrial subpopulations are critical to understanding aB metabolism and may play a role in identifying a potential mechanism for metabolic dysfunction. …

The Loss Function Of Usda Forecasters: Evidence From Wasde Animal Product Price Forecasts, Chad Fiechter, Siddhartha S. Bora, Todd H. Kuethe

Department of Agricultural Economics Faculty Publications

The loss function is a mathematical representation of the costs experienced by a forecaster when observed outcomes differ from what was predicted. Prior studies suggest that USDA forecasts are not optimal based on an assumed mean-zero quadratic loss function. This study proposes an alternative view of forecast evaluation, which assumes all USDA forecasts are produced to minimize the forecasters’ costs, and searches for the dimensions of the loss function under which optimality holds. We illustrate the degree to which USDA loss functions vary across a series of WASDE price forecasts. A better understanding of USDA forecasters’ costs will benefit forecasters …

Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Neurological disorders are linked to mitochondrial dysfunction and calcium overload. Mitochondrial calcium uptake is mediated by the mitochondrial calcium uniporter (mtCU), regulated by MICU1, which can be either homodimerized or heterodimerized with MICU2 or MICU3. Though MICU2 is scarce in the adult brain, MICU2 loss in patients leads to a neurodevelopmental disorder. We hypothesized that MICU2 is required for developmental calcium signaling and neuronal migration. MICU2 is present in the developing mouse brain but disappears by maturation, contrasting with other mtCU subunits that increase. MICU2 loss in mice does not affect cytoplasmic calcium but augments the mitochondrial matrix calcium rise …

Sox11 Modulates Bcr Signaling Through The Pax5/Cd19 Axis For Therapeutic Targeting In Btk-Resistant Mantle Cell Lymphoma, Rudra Prasad Dutta, Heng-Huan Lee, Violetta V Leshchenko, Ravi Prakash Shukla, Fangfang Yan, Yang Liu, H Ümit Kaniskan, Xing Qiu, Jian Jin, Lapo Alinari, Michael Wang, Samir Parekh

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) is an incurable subtype of B-cell non-Hodgkin lymphoma. Despite multiple approved Bruton tyrosine kinase inhibitors (BTKis), resistance to BTKi continues to pose a major clinical challenge. The transcription factor sex determining region Y-box 11 (SOX11) is expressed in most patients with MCL and is associated with poor outcomes. We have previously demonstrated SOX11-dependent B-cell receptor (BCR) signaling in transgenic models of MCL. Here, we report that SOX11 drives BCR signaling via the transcriptional activation of the PAX5/CD19 axis. The translational potential of these results is significant as single-cell RNA sequencing data show that SOX11 is overexpressed …

Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie

Faculty, Staff and Student Publications

Perinatal T cells have distinctive phenotypes and functions that may be due in part to age-associated features of stromal cells in the perinatal thymus. We identify age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging. Coordinated cellular and molecular changes occur at 7-14 days of age, designated "transitional ages," as thymus growth switches to homeostasis. E2F target gene expression declines, and the expression of type I interferon response genes increases across diverse cell types at transitional ages. Alterations in thymic stromal …

Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima

Makara Journal of Science

Organic waste comprises a considerable portion of global waste, requiring effective management. The ability of the black soldier fly (Hermetia illucens, BSF) to convert organic waste into biomass has been well reported. However, bioconversion can be hindered by fiber-rich substrates, a challenge that can be addressed through substrate pretreatment. This study examined the oviposition preferences and larval performance of BSFs in several fruit wastes fermented by effective microorganisms (EMs), which were compared to non-fermented substrates. The oviposition attractants utilized pineapple peel and overripe soursop, with larval performance evaluated among different treatments, i.e., non-fermented pineapple peel (NFP), fermented pineapple …

Neuroprotective Effects Of Aqueous Extract Of Bryophyllum Pinnatum Against Lead Acetate Induced Damage In The Cerebellum Of Rats, O. A. Bamgbose, O. D. Akanji, E. O. Olayemi, D. O. Taiwo-Ola, K. O. Odubela, B. A. Akanbi, P. B. Fakunle

AUIQ Complementary Biological System

Lead is a persistent environmental toxin with pronounced neurotoxic effects, particularly on the central nervous system. This study evaluated the impact of lead acetate on the cerebellar cortex of adult Wistar rats and assessed the neuroprotective effects of aqueous Bryophyllum pinnatum extract. Twenty adult Wistar rats (180–220 g) were randomly assigned to four groups (n = 5): Control (distilled water), T1 (0.075 mg/kg lead acetate), T2 (100 mg/kg B. pinnatum), and T3 (lead + B. pinnatum). Treatments were administered orally for 21 days. Cerebellar tissues were processed for biochemical and histological analysis, and data were analyzed using GraphPad Prism v10.1.Lead …

Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney

SURE Journal: Science Undergraduate Research Experience Journal

Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.

The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …

Editorial-Sure Journal Volume 7, Issue 2, Geraldine M. Dowling, Eva Campion, Sinead Loughran, Ariane Perez-Gavilan, Josephine Treacy

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Metal Exposures And Their Interactions With The Dietary Inflammatory Index On Inflammatory Biomarkers In Mexican Adolescents, Yanelli Rodríguez-Carmona, Ana Baylin, Peter X.K. Song, Edward Ruiz-Narvaez, Cindy W. Leung, James Hébert Scd, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth Msph, Phd, Face, Aljandra Cantoral, John D. Meeker, Niladri Basu, Martha María Tellez-Rojo, Karen E. Peterson, Sung Kyun Park

Faculty Publications

Background:

Heavy metals, like lead, arsenic, and cadmium, are linked to increased inflammation even in early life; however, anti-inflammatory diets may offset these effects.

Methods:

We evaluated associations between heavy metals and inflammatory biomarkers, and potential effect modification by diet in 399 adolescents aged 10 to 18 at baseline who attended two study visits 2 years apart (773 observations). At baseline, blood lead, urinary arsenic, and cadmium concentrations were measured, and the Children’s Dietary Inflammatory Index (C-DII) was calculated. Fasting serum interleukin (IL)-4, IL-10, IL-1β, IL-6, IL-8, high-sensitivity C-reactive protein, and tumor necrosis factor-alpha were measured for both visits. Generalized …

Will Technology Help Us Understand Animals?, Frances I. Sacks

Capstones

New technologies allow scientists to study animal communication like never before. Advanced surveillance devices ornament forests and oceans, recording animals over great stretches of distance and time. Artificial intelligence can absorb these enormous datasets, sorting tangled abstractions into coherent patterns. With a sufficiently robust library of analyzed data, some researchers believe that large language models will soon learn to translate whale communication systems.

https://docs.google.com/document/d/1ky6mPFjc-lNJFVK8CHebUa5zCSFUoMgkCB560pqxwfo/edit?tab=t.0