Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Engineering

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 5101 - 5130 of 196826

Full-Text Articles in Entire DC Network

Modern (Networked) Warfare: Its Concepts, Evolution, And Issues, Ramesh Subramanian Jan 2026

Modern (Networked) Warfare: Its Concepts, Evolution, And Issues, Ramesh Subramanian

Journal of International Technology and Information Management

The on-going Russo-Ukraine war (February 2012-present), the recent India-Pakistan war (May 7-10, 2025), and the Israel-US attacks on Iran (June 13, 2025) have become interesting for a variety of reasons, and garnered a lot of attention in international defense publications and weapons manufacturers. To many defense analysts and defense industry professionals, these wars have become real-life testing platforms to examine and evaluate various present-day war technologies. They have opened up discussion on the future of war, the increasing use of inter-connected networks in warfare, and the increasing use of remote-operated drones in conducting surveillance and in offensive actions against …


The Role Of Ict In Enhancing National Logistics Performance And Economic Productivity, Jin Ho Kim Jan 2026

The Role Of Ict In Enhancing National Logistics Performance And Economic Productivity, Jin Ho Kim

Journal of International Technology and Information Management

This study sheds light on the transformative impact of Information and Communication Technology (ICT) on national productivity via logistics performance. By distinguishing between mobile and wired Internet speeds, the research demonstrates how these technologies influence logistics performance and, in turn, national productivity across different economic contexts. The findings reveal a nuanced relationship between ICT and logistics performance, with mobile ICT playing a more significant role in developing countries due to its accessibility and cost-effectiveness. In contrast, developed countries benefit from a balanced integration of both mobile and wired ICT. Moreover, the study highlights the mediating role of logistics performance in …


Blockchain As A Digital Coordination Infrastructure For Project Management: A Systematic Review And Integrative Framework, Cherie Bakker Noteboom, Sai Neelima Seru, Aravindh Sekar Jan 2026

Blockchain As A Digital Coordination Infrastructure For Project Management: A Systematic Review And Integrative Framework, Cherie Bakker Noteboom, Sai Neelima Seru, Aravindh Sekar

Journal of International Technology and Information Management

Blockchain technology has gained increasing attention as a digital infrastructure capable of improving transparency, trust, and coordination in complex, multi-organizational project environments. However, existing research on blockchain-enabled project management remains fragmented and industry-focused, providing limited guidance for organizational adoption and integration. This study addresses this gap through a systematic literature review of 29 peer-reviewed studies, following PRISMA guidelines, to examine how blockchain capabilities are incorporated into project management practices across industries and maturity stages.

Grounded in Resource-Based View and Coordination Theory, the analysis employs a feature-to-process mapping approach to link six core blockchain capabilities—decentralization, transparency, immutability, smart contracts, traceability, and …


Assessment Of Soybean Response To Irrigation Variability In Eastern Nebraska Using The Aquacrop Model, Anmol Singh, Saleh Taghvaeian, Yufeng Ge, Derek M. Heeren, Frank Bai Jan 2026

Assessment Of Soybean Response To Irrigation Variability In Eastern Nebraska Using The Aquacrop Model, Anmol Singh, Saleh Taghvaeian, Yufeng Ge, Derek M. Heeren, Frank Bai

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soybean [Glycine max (L.) Merr.] is a major irrigated crop in eastern Nebraska, where recent expansions in irrigated agriculture and projected trends in irrigation demand necessitate thorough investigations of approaches that can optimize its irrigation management. In this study, the AquaCrop model was calibrated and validated using 19 variable irrigation treatments from a five-year field experiment. The model accurately simulated canopy cover, soil water content, and grain yield, with validation normalized root mean square error (nRMSE) of 12%, 7%, and 7%, respectively. The model was subsequently applied to estimate soybean yield and water requirement during a 15-year period (2010–2024) …


Efficient And Fair Resource Unit(Ru) Allocation Methods For The Ofdma Mechanism Under Ieee 802.11ax, Yang Yu Jan 2026

Efficient And Fair Resource Unit(Ru) Allocation Methods For The Ofdma Mechanism Under Ieee 802.11ax, Yang Yu

Doctoral

The IEEE 802.11ax standard was approved in February 2021. This standard allows users to access different channel bandwidths to transmit their packets under the Orthogonal Frequency Division Multiple Access (OFDMA) mechanism. As the number of Internet users and the number of Internet applications increase, the allocation of channel resources has been a challenge in WLANs. Different types of applications, such as real-time video conferencing, online gaming and large-scale data transfers, generate different requirements in terms of throughput, latency and reliability. Consequently, the diversity in users’ channel bandwidth demands is increasing. Under the OFDMA mechanism, the packets can be allocated into …


Sharing Patient-Generated Health Data With Electronic Health Record: A Standardised Provenance And Context-Rich Information Model And Clinician Evaluation, Abdullahi Abubakar Kawu Jan 2026

Sharing Patient-Generated Health Data With Electronic Health Record: A Standardised Provenance And Context-Rich Information Model And Clinician Evaluation, Abdullahi Abubakar Kawu

Dissertations

With the advent of Patient-Generated Health Data (PGHD) through wearable, mobile, and home monitoring systems, there is immense potential for ongoing monitoring and patient engagement. But integrating PGHD with Electronic Health Record (EHR) is challenged by sub-optimal support for contextual metadata and its relevant elements, lack of semantic interoperability among disparate systems, poor knowledge regarding the factors that impact clinician acceptance, and absence of globally agreed standards for data exchange. This thesis explores how contextually relevant patient-generated health data can be shared with EHRs through a FAIR standardized information model that ensures semantic and syntactic interoperability.

The study addresses six …


Deep Learning Framework For Sow Posture Classification From Depth Images: Comparison With Data Transformation Techniques, Models, And Cross-Validation, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Suzanne M. Leonard, Yeyin Shi Jan 2026

Deep Learning Framework For Sow Posture Classification From Depth Images: Comparison With Data Transformation Techniques, Models, And Cross-Validation, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Suzanne M. Leonard, Yeyin Shi

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Piglet preweaning mortality (PWM) in the United States averages ≈14–15%, with sow overlaying causing about one third proportion of these losses. This research aimed to develop and evaluate deep learning models to classify six sow postures using depth images to monitor behaviors linked to overlaying risk. Top-down depth images were captured with Kinect V2® cameras at 10 frames min-1 for five consecutive days (2 days before to 2 days after farrowing), yielding 26,506 training images from 18 sows, 17,901 testing images from 12 sows, and 4,697 additional images from three sows in diagonal stalls for external validation. Three …


Secondhand Books Industry Between Extinction And Challenges Of The New Millennium: Insights Urban And Architectural Considerations From Al-Azbakeya Book Market., Ahmed M. Selim, Heba M. Gaber, Nehal M. Elmahdy Jan 2026

Secondhand Books Industry Between Extinction And Challenges Of The New Millennium: Insights Urban And Architectural Considerations From Al-Azbakeya Book Market., Ahmed M. Selim, Heba M. Gaber, Nehal M. Elmahdy

Mansoura Engineering Journal

At the beginning of the 21st century, the printed and secondhand book industry has faced enormous challenges, particularly after the COVID-19 pandemic, when book consumers sought to engage directly with e-books. The Azbakeya Book Market in Egypt is one of the markets that confronts this challenge, while maintaining its distinctive historical character. This study aims to rehabilitate the secondhand book market in Al-Azbakeya district as a model that simulates the potential urban and sustainable architectural design strategies for reviving this industry. The study framework was comprised into four sections. First, "desk-based research" was conducted to discuss the secondhand book industry …


Green Hydrogen-Based Decarbonization Approach For Steel Industry With Hybrid Renewable Energy Sources, Raju Kumar Maurya, Dharmbir Prasad, Rudra Pratap Singh Jan 2026

Green Hydrogen-Based Decarbonization Approach For Steel Industry With Hybrid Renewable Energy Sources, Raju Kumar Maurya, Dharmbir Prasad, Rudra Pratap Singh

Mansoura Engineering Journal

This work provides a micro-pilot techno-economic and environmental assessment of a green hydrogen-driven decarbonization scenario for low-carbon steel production at the capacity of 1 ton steel produced (i.e., requiring 50 kg of green hydrogen). In this work an integrated renewable energy (RE) scenario for the steel production site at Jamuria, West Bengal, India is planned to utilize solar photovoltaic (PV), wind turbines (WTs), battery storage and a diesel backup generator to meet the hydrogen production load from an electrolyzer using HOMER Pro software. The results show that the proposed micro-pilot system produces excess electricity with respect to the plant's operating …


Intelligent Audio‑To‑Indian Sign‑Language And Sign‑To‑Audio Translation System Using Mediapipe, Tensorflow, Whisper And Google Tts, N. Pothanna, T. Kusuma, S. Haindavi, T. Sreeja, Shaik Shaheem Taj Jan 2026

Intelligent Audio‑To‑Indian Sign‑Language And Sign‑To‑Audio Translation System Using Mediapipe, Tensorflow, Whisper And Google Tts, N. Pothanna, T. Kusuma, S. Haindavi, T. Sreeja, Shaik Shaheem Taj

Mansoura Engineering Journal

Communication barriers between the Deaf community and the general public remain a persistent challenge, particularly in multilingual settings where Indian Sign Language (ISL) is the primary mode of interaction. We propose a real-time bidirectional translation framework integrating MediaPipe for hand landmark extraction, a Convolutional Neural Network (CNN) classifier built with TensorFlow/Keras for gesture recognition, OpenAI Whisper for robust multilingual speech-to-text transcription, and Google TTS for naturalistic speech synthesis. The system achieves 93% classification accuracy across 35 ISL classes (alphabets A–Z and numerals 1–9) on a dataset of 42,700 images, with macro and weighted F1-scores of 0.93. Deployed as a Flask …


Analytical Study Of Transient Mixed Convective Radiative Jeffrey Fluid Flow With Diffusion–Thermo And Chemical Reaction, V. Sathiya, R. Vijayaragavan, B. Rushi Kumar Jan 2026

Analytical Study Of Transient Mixed Convective Radiative Jeffrey Fluid Flow With Diffusion–Thermo And Chemical Reaction, V. Sathiya, R. Vijayaragavan, B. Rushi Kumar

Mansoura Engineering Journal

This research examines the behavior of unsteady mixed convective radiative Jeffrey fluid flow over a permeable moving plate with a diffusion thermo effect. The study incorporates multiple factors, including aligned magnetic fields, heat generation, radiation, and chemical reactions. The behavior of Jeffrey fluid under these combined conditions is particularly relevant to the design of efficient heat exchangers, MHD generators, and cooling systems for electronic components. A regular perturbation technique was employed to solve the governing equations, yielding distributions for velocity, temperature, and species concentration. These solutions enabled the derivation of expressions for skin friction, Nusselt number, and Sherwood number. Through …


A Quantitative Analysis Of Burrowing And Subterranean Locomotion In The Sand Lance Using A Transparent Sediment, Issei Fujita, Makoto Tomiyasu, Jun Yamamoto, Yasuzumi Fujimori Jan 2026

A Quantitative Analysis Of Burrowing And Subterranean Locomotion In The Sand Lance Using A Transparent Sediment, Issei Fujita, Makoto Tomiyasu, Jun Yamamoto, Yasuzumi Fujimori

Journal of Marine Science and Technology–Taiwan

Sand lances (Ammodytes spp.) rely on rapid burrowing into sediment for predator avoidance. Although their sediment grain-size preferences are well documented, the biomechanics underlying burrowing success remain unclear because natural substrates are opaque. Using a transparent-sediment system, we directly visualized and quantified burrowing kinematics to: (1) test the effect of body size (total length, TL) on burrowing success; (2) examine entry mechanisms (e.g., swimming speed, entry angle); and (3) describe locomotion within sediment. Logistic regression on the full dataset (N = 28 fish) identified TL as the primary determinant of success, with larger individuals exhibiting significantly higher success …


Cruise Network Design Under Sequential Duopolistic Entry, Ta-Hui Yang, Ching-Hui Tang, Wan-Tien O Jan 2026

Cruise Network Design Under Sequential Duopolistic Entry, Ta-Hui Yang, Ching-Hui Tang, Wan-Tien O

Journal of Marine Science and Technology–Taiwan

This study addresses the network design for international cruise services in a duopolistic market, where carriers enter and make decisions sequentially. The leader, who makes the first move, makes decisions as there is no competitor in the market. The follower, who makes decisions later, has to design their network considering the existing leader’s network. The leader’s model is a mixed integer linear problem while the follower’s model is a mixed integer nonlinear problem. Therefore, a heuristic is proposed to solve the problem. The commercially available general algebraic modeling system is used in conjunction with its different solvers to solve the …


Effect Of Heat Treatment On The Corrosion And Wear Behavior Of 17-4 Ph Stainless Steel For Marine Applications, Syuan Tai, I-Kon Lee, Ming-Yuan Lin, Kang-Yu Liao, Chin-Chun Chang, Hung-Bin Lee Jan 2026

Effect Of Heat Treatment On The Corrosion And Wear Behavior Of 17-4 Ph Stainless Steel For Marine Applications, Syuan Tai, I-Kon Lee, Ming-Yuan Lin, Kang-Yu Liao, Chin-Chun Chang, Hung-Bin Lee

Journal of Marine Science and Technology–Taiwan

This study explores the tribocorrosion behavior of conventionally cast 17-4 PH stainless steel under real seawater conditions, focusing on the effects of three heat treatments (Solution, H900, H1100). Electrochemical tests, tribocorrosion experiments, SEM, XPS, and quantitative analysis were used to establish a three-stage tribocorrosion mechanism. Results show that H900 exhibits superior corrosion and wear resistance, while H1100 suffers increased material loss and surface cracking at high potentials. Elemental analysis revealed NbC migration forming third-body particles, which, although briefly reducing friction, induced local stress concentration and crack initiation. The findings highlight the critical influence of microstructure, passive film stability, and third-body …


Enhancing Underwater Imagery And Organism Detection Using Reinforcement Learning, K. Arul Deepa, P. Ramya, Karpaga Vinodha, Dharmaraja C Jan 2026

Enhancing Underwater Imagery And Organism Detection Using Reinforcement Learning, K. Arul Deepa, P. Ramya, Karpaga Vinodha, Dharmaraja C

Journal of Marine Science and Technology–Taiwan

Underwater environments pose significant challenges in assessing image quality and organism detection due to light scattering and absorption, which limits visibility and color fidelity. Existing solutions often fail to effectively address these challenges, resulting in suboptimal image quality and hindering organism identification. This paper examines the problem through a dual-focused approach: enhancing underwater images and detecting organisms using the Underwater Image Enhancement Benchmark (UIEB) dataset. The first step introduces a state-of-the-art method for image enhancement by applying reinforcement learning (RL) principles. By formulating the enhancement process as a Markov Decision Process (MDP)—where states are represented by image features and actions …


Development Of An Adhesive Emulsion Hydrogel For Soft Tissue Reconstruction, David J. Alpert Jan 2026

Development Of An Adhesive Emulsion Hydrogel For Soft Tissue Reconstruction, David J. Alpert

Dissertations and Theses

Soft tissue filling materials are most commonly associated with various aesthetic, cosmetic procedures, primarily using lightly cross-linked hyaluronic acid to fill wrinkles and give facial features a more youthful appearance. These natural materials are biocompatible but degrade over time while more persistent synthetic fillers may provoke a chronic inflammatory response. Migration from the injection site is also a key factor as this may not only render the implant non- functional but necessitate further procedures for removal of the foreign material. Such concerns are more pronounced for soft tissue reconstruction procedures (e.g., to treat congenital defects or traumatic injuries), which require …


Design, Testing And Controls For Air Source Heat Pump System In Cold Climates Using Natural & Conventional Refrigerants, S M Abdur Rob Jan 2026

Design, Testing And Controls For Air Source Heat Pump System In Cold Climates Using Natural & Conventional Refrigerants, S M Abdur Rob

Dissertations and Theses

Fossil-fuel based heating systems used in the residential buildings in northeastern U.S region are not only inefficient but also largely responsible for the greenhouse gas emissions in U.S. Electrification of the buildings has been proved to be the most efficient way to reduce the greenhouse gas emissions where Heat Pumps can be the best alternative to replace the natural gas based heating system to accelerate the electrification process. Among different types of heat pumps, the Air Source Heat Pump (ASHP) system is widely used due to the easy installation and energy efficiency. Conventional heat pump technologies use various types of …


Beyond The Honeypot: Increasing Adversarial Cognitive Load Through Interactionless Cyber Deception, Marcus Rozier, Connor Dedic, Ted Mcdaniel, Hadley Westover Jan 2026

Beyond The Honeypot: Increasing Adversarial Cognitive Load Through Interactionless Cyber Deception, Marcus Rozier, Connor Dedic, Ted Mcdaniel, Hadley Westover

Space Dynamics Laboratory Publications

Traditional cyber deception mechanisms, such as honeypots and honey-tokens, typically rely on adversary interaction to trigger alerts and provide defensive value. This paper introduces the concept of interactionless deception—a defensive paradigm focused on the strategic manipulation of the environment to disrupt the cyber kill chain without requiring direct engagement. By utilizing a greedy top-k selection method to analyze MITRE ATT&CK® data across 178 Advanced Persistent Threat (APT) groups, this research identifies seven high-frequency sub-techniques that represent common attacker behavior. To counter these, the authors developed a series of proof-of-concept tools, including deceptive web proxies, simulated command-and-control (C2) beacons, and …


A Low Noise, High Qe, Large Format Ccd Camera System For The Nasa Mighti Instrument, Jed Hancock, Joel Cardon, Mike Watson, James Cook, Mitch Whiteley, James Beukers, Chris Englert, Charlie Brown, John Harlander Jan 2026

A Low Noise, High Qe, Large Format Ccd Camera System For The Nasa Mighti Instrument, Jed Hancock, Joel Cardon, Mike Watson, James Cook, Mitch Whiteley, James Beukers, Chris Englert, Charlie Brown, John Harlander

Space Dynamics Laboratory Publications

Outline

  • MIGHTI Instrument Overview and Configuration
  • Camera System Block Diagram
  • Flight Camera Heads, Electronics Box, and CCDs
  • CCD Testing at e2v
  • AI&T at the Space Dynamics Lab
  • Electro-Optical Characterization and Performance Results
  • Conclusions


Climate Change Impacts On Hydrology In The Upper James Watershed, Imiya Mudiyanselage Chathuranika, Dalya Ismael Jan 2026

Climate Change Impacts On Hydrology In The Upper James Watershed, Imiya Mudiyanselage Chathuranika, Dalya Ismael

Engineering Technology Faculty Publications

Hydrological modeling of the Upper James Watershed (UJW), Virginia, is critical for predicting water availability, flood management, agriculture, ecosystem protection, and hydropower production under increasing climate change. The Hydrologic Engineering Center-Hydrologic Modeling System (HEC-HMS) is applied to evaluate climate change impacts on key hydrological components within the watershed. Future climate conditions were assessed for the near (NF: 2026-2050), mid (MF: 2051-2075), and far (FF: 2076-2100) periods using three Global Climate Models (GCMs) under Shared Socioeconomic Pathways SSP 2-4.5 and SSP 5-8.5. Climate data were bias-corrected using the Linear Scaling Method (LSM) and used to drive the HEC-HMS model. Results project …


Identifying Industry-Preferred Automation Software In Engineering: An Indeed-Based Analysis To Inform Engineering Technology Curriculum Design, Triet Minh Phan, Collins Okafor, Winifred Okafor, Devang Mehta, Mohsen Souissi, Jenora Waterman, Connie Mayberry, Misty Thomas, Orlando Ayala, Angie Price, Maurizio Manzo Jan 2026

Identifying Industry-Preferred Automation Software In Engineering: An Indeed-Based Analysis To Inform Engineering Technology Curriculum Design, Triet Minh Phan, Collins Okafor, Winifred Okafor, Devang Mehta, Mohsen Souissi, Jenora Waterman, Connie Mayberry, Misty Thomas, Orlando Ayala, Angie Price, Maurizio Manzo

Engineering Technology Faculty Publications

In the evolving field of automation engineering, staying aligned with industry software demands is critical to preparing graduates for the modern workforce. This study investigates the prevalence of leading industrial automation platforms—Rockwell / Allen-Bradley (RSLogix / Studio 5000), Siemens (TIA Portal / Step 7), and Schneider Electric (EcoStruxure / Unity Pro)—across job postings collected from Indeed using the keyword "automation engineering." The research compiles a structured dataset of job postings with seven fields: ID, Job Title, Organization, Rockwell / Allen-Bradley, Siemens, Schneider Electric, and Posting URL. Each entry is manually coded to indicate whether the listed software platforms are mentioned, …


Improving Medical Diagnostics With Vision-Language Models: Convex Hull-Based Uncertainty Analysis, Ferhat Ozgur Catak, Murat Kuzlu, Taylor Patrick, Michel Audette Jan 2026

Improving Medical Diagnostics With Vision-Language Models: Convex Hull-Based Uncertainty Analysis, Ferhat Ozgur Catak, Murat Kuzlu, Taylor Patrick, Michel Audette

Engineering Technology Faculty Publications

In recent years, vision-language models (VLMs) have been applied to various fields, including healthcare, education, finance, and manufacturing, with remarkable performance. However, concerns remain regarding VLMs’ consistency and uncertainty, particularly in critical applications such as healthcare, which demand a high level of trust and reliability. This paper proposes a novel approach to evaluate uncertainty in VLMs’ responses using a convex hull approach on a healthcare application for visual question answering (VQA). For any VLM, temperature refers to a sampling parameter used in probabilistic generation, which controls the randomness of the model’s output. The LLM-CXR model is selected as the medical …


Artificial Intelligence (Ai) In Educating Next Generation Of Engineering Technology Students, Adel El-Shahat, Murat Kuzlu, Vukica M. Jovanovic, Katherine Smith, Abdullah Al Mamun, Otilia Popescu Jan 2026

Artificial Intelligence (Ai) In Educating Next Generation Of Engineering Technology Students, Adel El-Shahat, Murat Kuzlu, Vukica M. Jovanovic, Katherine Smith, Abdullah Al Mamun, Otilia Popescu

Engineering Technology Faculty Publications

Artificial Intelligence (AI) is transforming education, particularly for electrical engineering technology (EET) students, by presenting adaptive learning, immediate responses, and unconventional tools. Therefore, this paper proposes investigating modern learning to employ AI in educating future electrical engineering technology students. Firstly, the paper explores how to shape AI knowledge for EET students, supplying them with hands-on skills in AI tasks, clarifying coding, data analysis, and AI ethical usage. Then, as educators, what are the efficient AI tools to utilize in teaching, such as tailored tutoring, automated code assessment, AI-driven design/simulation, lecture dictation, and smart content creation? Key tools, for instance, Google …


Circulating Biomarker Results From A Phase 2 Study Of Seralutinib In Pulmonary Arterial Hypertension, Robin Osterhout, Athénaïs Boucly, Raymond L. Benza, Richard N. Channick, Kelly M. Chin, Robert P. Frantz, Anna R. Hemnes, Luke S. Howard, Vallerie V. Mclaughlin, Olivier Sitbon, Jean-Luc Vachiéry, Rotham T. Zamanian, Richard Aranda, Matt Cravets, Zhaoqing Ding, Thao Duong-Verlé, David Mattola, Robert F. Roscigno, Ravikumar Sitapara, Lawrence S. Zisman, Jean-Marie Bruey, Hossein-Ardeschir Ghofrani Jan 2026

Circulating Biomarker Results From A Phase 2 Study Of Seralutinib In Pulmonary Arterial Hypertension, Robin Osterhout, Athénaïs Boucly, Raymond L. Benza, Richard N. Channick, Kelly M. Chin, Robert P. Frantz, Anna R. Hemnes, Luke S. Howard, Vallerie V. Mclaughlin, Olivier Sitbon, Jean-Luc Vachiéry, Rotham T. Zamanian, Richard Aranda, Matt Cravets, Zhaoqing Ding, Thao Duong-Verlé, David Mattola, Robert F. Roscigno, Ravikumar Sitapara, Lawrence S. Zisman, Jean-Marie Bruey, Hossein-Ardeschir Ghofrani

Department of Medicine Faculty Publications

[Introduction] To the Editor: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by obstructive pulmonary arterial remodeling (1). Seralutinib, an investigational inhaled tyrosine kinase inhibitor, potently and selectively targets kinases relevant to PAH pathobiology including platelet-derived growth factor receptors (PDGFR) α and β, colony stimulating factor 1 receptor (CSF1R), and mast/stem cell growth factor receptor kit (c-KIT) (2). In preclinical models, seralutinib improved cardiopulmonary hemodynamics, reversed pulmonary vascular pathology and decreased right ventricular hypertrophy (3). In TORREY, a phase 2, multicenter, double-blind, randomized, placebo-controlled trial in PAH, seralutinib significantly reduced pulmonary vascular resistance (PVR) after 24 weeks with good …


Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson Jan 2026

Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson

Department of Medicine Faculty Publications

Micro- and nanoplastics (MNPs) are pervasive in food-contact environments and the human diet, positioning the gastrointestinal (GI) tract as the primary portal of entry and a plausible site of early biological effects. Human exposure is supported by detection of microplastics in stool and colon tissue, and emerging clinical studies report associations between fecal microplastic burden and GI disease states, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). Preclinical studies provide mechanistic plausibility, reporting that ingested MNPs can modulate microbial ecology, alter mucus membrane integrity, increase intestinal permeability through changes in cellular tight junction biology, and induce inflammatory gene expression. …


Micro- And Nanoplastics: A Paradigm Shift In The Pathogenesis Of Inflammatory Bowel Disease, Michael Saadeh, Priyata Dutta, Gordon Hong, Edward Oldfield, David A. Johnson Jan 2026

Micro- And Nanoplastics: A Paradigm Shift In The Pathogenesis Of Inflammatory Bowel Disease, Michael Saadeh, Priyata Dutta, Gordon Hong, Edward Oldfield, David A. Johnson

Department of Medicine Faculty Publications

Micro- and nanoplastics (MNPs) are pervasive environmental contaminants with growing recognition as potential contributors to human disease. Widespread human exposure occurs primarily through ingestion of contaminated food and water, and MNPs have been detected in multiple human tissues, including the gastrointestinal tract. Experimental evidence provides a plausible biological basis for disease associations, including impairment of intestinal barrier integrity, activation of mucosal immune pathways, and alteration of gut microbial communities caused by MNP exposure. Although human data remain limited, early studies demonstrate MNP detection in stool and suggest potential correlations with inflammatory biomarkers such as fecal calprotectin. These findings, together with …


Microplastics, Nanoplastics, And Obesity: Current Evidence And Biological Mechanisms, Maram Albandak, Sanam Rabeeah, Ahmad Mahdi Zahidi, David A. Johnson Jan 2026

Microplastics, Nanoplastics, And Obesity: Current Evidence And Biological Mechanisms, Maram Albandak, Sanam Rabeeah, Ahmad Mahdi Zahidi, David A. Johnson

Department of Medicine Faculty Publications

Obesity is a rapidly growing global health concern. The pathogenesis is complex and cannot be fully explained by lifestyle factors alone. The increasing attention towards this concern has finally been directed towards environmental contributors which may influence metabolic regulation. Microplastics and nano-plastics (MNPs) are ubiquitous environmental pollutants that have recently been detected in food, drinking water, air, and human biological samples, raising concerns about their potential role in metabolic disorders, including obesity. Chronic exposure to MNPs may interfere with metabolic homeostasis through multiple biological pathways. Emerging evidence, including both experimental and animal studies, reports alterations in lipid metabolism, body weight, …


Choice-Based Crowdshipping For Next-Day Delivery Services: A Dynamic Task Display Problem, Alp Arslan, Firat Kilci, Shih-Fen Cheng, Archan Misra Jan 2026

Choice-Based Crowdshipping For Next-Day Delivery Services: A Dynamic Task Display Problem, Alp Arslan, Firat Kilci, Shih-Fen Cheng, Archan Misra

Research Collection School Of Computing and Information Systems

This paper studies integrating the crowd workforce into next-day home delivery services. In this setting, both crowd drivers and contract drivers collaborate in making deliveries. Crowd drivers have limited capacity and can choose not to deliver if the presented tasks do not align with their preferences. The central question addressed is: How can the platform minimize the total task fulfilment cost, which includes payouts to crowd drivers and additional payouts to contract drivers for delivering the unselected tasks by customizing task displays to crowd drivers? To tackle this problem, we formulate it as a finite-horizon Stochastic Decision Problem, capturing crowd …


Learning-Based Graph Shrinking For Quantum Optimization Of Constrained Combinatorial Problems, Monit Sharma, Hoong Chuin Lau Jan 2026

Learning-Based Graph Shrinking For Quantum Optimization Of Constrained Combinatorial Problems, Monit Sharma, Hoong Chuin Lau

Research Collection School Of Computing and Information Systems

Graph shrinking has recently emerged as a powerful preprocessing technique for hybrid classical–quantum optimization, enabling variable and constraint reduction before quantum solving. Conventional approaches rely on Semi-Definite Programming (SDP) relaxations to compute vertex correlations, but these methods suffer from high computational overhead, instance-specific tuning, and limited generalizability. In this work, we replace the handcrafted SDP correlation stage with a reinforcement learning (RL) based correlation estimator, trained to predict merge quality directly from graph structure. We reformulate the graph shrinking process as a Markov Decision Process (MDP), design a Graph Neural Network (GNN) policy to guide vertex merging, and integrate the …


Dystop: Dynamic Staleness Control And Topology Construction For Asynchronous Decentralized Federated Learning, Yizhou Shi, Qianpiao Ma, Yan Xu, Junlong Zhou, Ming Hu, Yunming Liao Jan 2026

Dystop: Dynamic Staleness Control And Topology Construction For Asynchronous Decentralized Federated Learning, Yizhou Shi, Qianpiao Ma, Yan Xu, Junlong Zhou, Ming Hu, Yunming Liao

Research Collection School Of Computing and Information Systems

Federated Learning (FL) has emerged as a potential distributed learning paradigm that enables model training on edge devices (i.e., workers) while preserving data privacy. However, its reliance on a centralized server leads to limited scalability. Decentralized federated learning (DFL) eliminates the dependency on a centralized server by enabling peer-to-peer model exchange. Existing DFL mechanisms mainly employ synchronous communication, which may result in training inefficiencies under heterogeneous and dynamic edge environments. Although a few recent asynchronous DFL (ADFL) mechanisms have been proposed to address these issues, they typically yield stale model aggregation and frequent model transmission, leading to degraded training performance …