Digital Commons Network^™

Automatic Tourniquet For Military Emergencies, Arshia Nazerani Houshmand, Marina Felt, Blake Juett

Biomedical Engineering

This document contains the progress and development of an automated tourniquet that would be intended for use within the United States military. The project was student-led and sponsored. Coordination and confirmation of our device was provided by Dr. John F. Kragh, who is part of the U.S. Army Institute of Surgical Research. The document will outline the research conducted on tourniquets, specification development of the tourniquet, morphology process, and final design production of the automatic tourniquet.

Newly Developed Antifouling Coating Alloys For Hydraulic Cylinder Applications, Christopher Liam Fahey, Robin Ashley Payne

Materials Engineering

In a marine environment solid surfaces are subject to corrosion and fouling, which is the buildup of unwanted material such as algae and barnacles, that can impede the functionality of components. The application that this project focuses on are hydraulic cylinders. Eight alloys, including three newly developed alloys, were tested for marine fouling performance. Three of the alloys were primarily NiCr, these included Inconel 625, Metco 1720, and P105-X3. Four alloys contained varying amounts of Cu, and these were Monel 400, CuproNickel, Monel 450, and P76-X24. Finally, one sample of a Co-based alloy was also tested, Ultimet. Of the samples …

Effect Of Dissolved Oxygen On Corrosion Of Carbon And 13cr Steel In A Brine Environment, Kevin Peter Iu, Andy Zhou

Materials Engineering

Oxygen corrosion is a major threat to seawater injection systems that are part of offshore drilling operations. Seawater is typically deoxygenated to an industry standard of(DO) by injection through a deaeration column followed by treatment with oxygen scavenging chemicals. Commercial simulation software like OLI Studio: Corrosion Analyzer predicts high corrosion rates when injection seawater contains high DO levels, justifying deoxygenation. However, a notable lack of experimental data exists concerning the effect of varying levels of dissolved oxygen on corrosion rate. The goal of this project is to measure the effect of three dissolved oxygen levels (0, 62, and 620 ppb) …

Uv Polymerization Of A Zwitterionic Antifouling Membrane Coating, Amanda Jia-Hwa Tsai, Vincent Matthew Guarino

Materials Engineering

Membrane filtration is used in a wide array of industries to separate components in a mixture. Filtration membranes suffer from the external deposition of pollutants and microorganisms, a phenomenon known as fouling. Fouling reduces the lifetime of a membrane and therefore increases production costs. The goal of this project was to modify the surface of a hydrophobic commercial membrane with a charged coating to induce antifouling properties. A zwitterionic monomer, sulfobetaine methacrylate (SBMA), was used for its steric hindrance and hydration shell formation mechanisms, which result in superior non-specific antifouling performance. When polymerizing the coating onto the surface of the …

Effects Of Uv Exposure On The Thermo-Mechanical Properties Of Cactus Based Biopolymers, Madison Glozer, Megan Bolling, Addison Wolfson

Materials Engineering

The viability of renewable biopolymers as sustainable alternatives to synthetic plastics is promising, however ultra-violet (UV) radiation can lead to premature degradation and reduction in the material’s performance. Biopolymers comprised of nopal cactus juice, animal protein, natural wax, and glycerin in differing percentages were studied to obtain thermo-mechanical data in relation to UV exposure. To quantify degradation, dynamic mechanical analysis, thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy, goniometry and gravimetric measurements were performed. Each formulation experienced mass loss as a result of UV exposure, which could be attributed to water evaporation. The thermogravimetric analysis indicated a reduction in the second …

The Effects Of Glass Fiber Fillers On Epoxy Resin Performance, Ashton Robert Reinhold, Manuel Jose Aguirre Ii

Materials Engineering

Premature failure of filtration members in biochemical processing is a costly issue for manufacturers. This research aims to determine whether or not the premature failure due to thermal fatigue in medical filtration devices can be mitigated by glass fiber addition. The study was conducted to identify the effects of e-glass fiber filler content in an epoxy matrix on the mechanical and thermal properties of the epoxy system. The epoxy was evaluated over a filler content of 0-50wt% in level increments of 12.5wt% and temperatures ranging from ambient to 160°C in increments of 15°C. Cylindrical and tensile bar specimens were prepared …

Solvent Analysis Of Phenolic Resin Glass Fiber Reinforced Prepreg During Out-Time, Sixin Zhai, Crystal Ipong

Materials Engineering

Phenolic resin glass fiber reinforced prepregs are highly suitable for airplane interior components due to their high fire resistance, high temperature performance, and low-density characteristics. Safran Cabin seeks to improve their storage of the phenolic resin prepreg during their manufacturing process. The issues the company faces are the occasional delamination of prepreg laminas or the loss of tackiness rendering the lamina unfit for use. The area of investigation was determining the weight loss of volatiles during out-time. The term “out-time” consists of the time the prepreg experiences in transit, on the shop floor, and in short-term temperature-controlled storage. Simulated storage …

Reducing The Fouling Of Microfiltration Membranes Through Uv-Initiated Surface Modifications Using Poly (Ethylene Glycol) Based Monomers, Christopher Lo, Matthew Truong

Materials Engineering

Meissner Filtration Product Inc. designs and manufactures membranes for food and beverage, microelectronics, ultrapure chemicals, and pharmaceutical industries. Membrane filters utilized in these industries have lifetimes greatly limited due to membrane fouling. Increasing membrane lifetime will reduce downtime, waste, and cost of operation. The proposed project is aimed to develop a methodology for synthesizing a fouling-resistant polymer coating layer on hydrophobic membrane surfaces for reducing membrane fouling and increasing membrane filterability (membrane lifetime) that are critical for effective membrane operations in the pharmaceutical industry. In this study, commercial membranes were coated with a solution containing a monomer, crosslinker, and photoinitiator …

Development Of A Marine Biodegradable Target Balloon, Blake Samuel Robinson, Arash Sam Akhavi, David Leonardo Albarran-Martinez

Materials Engineering

The US Navy utilizes PVC target balloons, known as Killer Tomatoes, that are inflated onboard a naval vessel then deployed into the ocean to calibrate a variety of weaponry. The Navy has requested the investigation of biodegradable polymers to replace the PVC in attempts to reduce ocean waste that is generated from the leftover PVC material. After communicating with American Pacific Plastic Fabricators (APPF), the current manufacturer of the Killer Tomatoes, we gained an understanding of the manufacturing process and the material requirements that would allow a new material to be integrated into their current process. Two proprietary, trial polymers …

Automating Deep-Sea Video Annotation, Hanson Egbert

Master's Theses

As the world explores opportunities to develop offshore renewable energy capacity, there will be a growing need for pre-construction biological surveys and post-construction monitoring in the challenging marine environment. Underwater video is a powerful tool to facilitate such surveys, but the interpretation of the imagery is costly and time-consuming. Emerging technologies have improved automated analysis of underwater video, but these technologies are not yet accurate or accessible enough for widespread adoption in the scientific community or industries that might benefit from these tools.

To address these challenges, prior research developed a website that allows to: (1) Quickly play and annotate …

A Wirelessly Controlled Scalable 3d-Printed Microsystem For Drug Delivery, Farzad Forouzandeh, Nuzhet N. Ahamed, Xiaoxia Zhu, Parveen Bazard, Krittika Goyal, Joseph P. Walton, Robert D. Frisina, David A. Borkholder

Chemical and Biochemical Engineering Faculty Research & Creative Works

Here we present a 3D-printed, wirelessly controlled microsystem for drug delivery, comprising a refillable micro reservoir and a phase-change peristaltic micropump. The micropump structure was inkjet-printed on the back of a printed circuit board around a catheter microtubing. The enclosure of the microsystem was fabricated using stereolithography 3D printing, with an embedded micro reservoir structure and integrated micropump. In one configuration, the microsystem was optimized for murine inner ear drug delivery with an overall size of 19 x 13 x 3 mm3. Benchtop results confirmed the performance of the device for reliable drug delivery. The suitability of the device for …

Modeling Vadose Zone Hydrology [Lecture Notes], Derek M. Heeren, Dean E. Eisenhauer

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Modeling Vadose Zone Hydrology is a graduate-level course offered biennially in the Department of Biological Systems Engineering. Topics included hydraulic properties of porous media, application of Darcy's Law in variably saturated media, hydrologic and transport processes in the vadose zone, and solution of steady and unsteady flow problems using numerical techniques. A graphical approach for characterizing vertical one-dimensional problems with energy head profiles was emphasized. Common one-dimensional flow and transport problems were solved analytically. The course was taught using a combination of lecture notes and PowerPoint presentations. The lecture notes from 2021, captured using the Microsoft Whiteboard app with a …

The Impact Of Myoblast Transplantation On Collateral Capillary Arteriogenesis And Macrophage Phenotype, Christine Hue Do

Biomedical Engineering

Gangrene, pain, loss of limb function, amputation, and death are only few of the grievous consequences associated with peripheral arterial disease (PAD), a vascular disease caused by an obstruction that narrows the blood vessels. Since some patients have collateral vessels that can re-route blood to its downstream destination, much focus has been spotlighted upon discovering the mechanism of this process, termed arteriogenesis, as well as cell therapies to increase arterial diameter of collateral vessels. Since some patients do not have native pre-existing collateral vessels, another method to re-route blood is through arterialized collateral capillaries (ACC), which is the conversion of …

Roles Of Key Ion Channels And Transport Proteins In Age-Related Hearing Loss, Parveen Bazard, Robert D. Frisina, Alejandro A. Acosta, Sneha Dasgupta, Mark A. Bauer, Xiaoxia Zhu, Bo Ding

Chemical and Biochemical Engineering Faculty Research & Creative Works

The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not …

Extraction And Bioactivity Evaluation Of Antioxidant Components From Teucrium Stocksianum Bioss Collected From Uae, Ahmad Ayman Al Salloum

Theses

Recently, the industry of Natural Bioactive Compounds (NBAC) is expanding dramatically due to its high medical potentials. High bioactivity of natural extracts from a wide range of plants is evident from the reported literature. For instance, NBACs show antibacterial, antifungal, antimicrobial, anti-inflammatory, anticancer and antioxidant activities. Teucrium stocksianum Boiss. from the Lamiaceae family is a known herb in the traditional medicine in United Arab Emirates. Multiple bioactivities of T. stocksianum were recorded such as anti-inflammation, analgesia, antioxidation, anticancer, antinociception and antimicrobial bioactivity. In this thesis, the extraction of NBACs from T. stocksianum was studied with Microwave-assisted extraction using Deep eutectic …

Label-Free Multiphoton Microscopy For The Detection And Monitoring Of Calcific Aortic Valve Disease, Ishita Tandon, Kyle P. Quinn, Kartik Balachandran

Biomedical Engineering Faculty Publications and Presentations

Calcific aortic valve disease (CAVD) is the most common valvular heart disease. CAVD results in a considerable socio-economic burden, especially considering the aging population in Europe and North America. The only treatment standard is surgical valve replacement as early diagnostic, mitigation, and drug strategies remain underdeveloped. Novel diagnostic techniques and biomarkers for early detection and monitoring of CAVD progression are thus a pressing need. Additionally, non-destructive tools are required for longitudinal in vitro and in vivo assessment of CAVD initiation and progression that can be translated into clinical practice in the future. Multiphoton microscopy (MPM) facilitates label-free and non-destructive imaging …

Virus And Bacteria Inactivation Using Ultraviolet Light-Emitting Diodes, Vincent Martino, Kyra Oschsner, Paige Elyse Peters, Daniel Zitomer, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

The control of infectious diseases is a critical challenge in developing and developed nations alike. Humans can be exposed to pathogenic microorganisms such as viruses and bacteria through numerous routes of transmission, including waterborne transmission. Accordingly, effective water disinfection processes are paramount for public health protection. In this study, the inactivation efficacy of P22 virus and Escherichia coli bacteria was tested using ultraviolet light-emitting diodes (UV LEDs), which provided effective disinfection of both waterborne microorganisms. Using a peak wavelength emission of 255, 265, or 285 nm, the batch-test, UV LED collimated beam system demonstrated high inactivation potential for both microorganisms …

Maize Tassel Detection From Uav Imagery Using Deep Learning, Aziza Alzadjali, Mohammed H. Alali, Arun Narenthiran Weeranampalayam Sivakumar, Jitender S. Deogun, Stephen Scott, James C. Schnable, Yeyin Shi

Department of Mechanical and Materials Engineering: Faculty Publications

The timing of flowering plays a critical role in determining the productivity of agricultural crops. If the crops flower too early, the crop would mature before the end of the growing season, losing the opportunity to capture and use large amounts of light energy. If the crops flower too late, the crop may be killed by the change of seasons before it is ready to harvest. Maize flowering is one of the most important periods where even small amounts of stress can significantly alter yield. In this work, we developed and compared two methods for automatic tassel detection based on …

High Performance Mixed-Matrix Electrospun Membranes For Ammonium Removal From Wastewaters, Shu-Ting Chen, Sumith Ranil Wickramasinghe, Xianghong Qian

Chemical Engineering Faculty Publications and Presentations

Mixed-matrix electrospun membranes were developed to investigate ammonium removal from low ammonium concentration wastewaters for the first time. Particles derived from the inexpensive zeolite 13X were successfully incorporated into polyethersulfone (PES) matrices. The fabricated mixed-matrix electrospun membranes demonstrate high ammonium removal capacity reaching over 55 mg/g_zeolite, more than 2.5 times higher than the previously fabricated mixed-matrix membranes via non-solvent induced phase inversion. Moreover, the membranes fabricated exhibit high permeability and ease of regeneration. Over 90% of total ammonium nitrogen (TAN) can be removed from low TAN wastewaters such as aquaculture wastewaters. In addition to zeolite 13X, other zeolite …

Selective Neural Stimulation By Leveraging Electrophysiological Diversity And Using Alternative Stimulus Waveforms, Bemin Ghobreal

Dissertations

Efforts on finding the principle mechanism for selective neural stimulation have concentrated on segregating the neurons based on their size and other geometric factors. However, neuronal subtypes found in different parts of the nervous system also differ in their electrophysiological properties. The primary objective of this study is to investigate the feasibility of selective activation of neurons by leveraging the diversity seen in passive and active membrane properties.

Using both a local membrane model and an axon model based on the CRRSS, the diversity of electrophysiological properties is simulated by varying four model parameters (membrane leakage-Gleak and capacitance-Cm, temperature coefficient-Ktemp, …

Development Of Deep Learning Neural Network For Ecological And Medical Images, Shaobo Liu

Dissertations

Deep learning in computer vision and image processing has attracted attentions from various fields including ecology and medical image. Ecologists are interested in finding an effective model structure to classify different species. Tradition deep learning model use a convolutional neural network, such as LeNet, AlexNet, VGG models, residual neural network, and inception models, are first used on classifying bee wing and butterfly datasets. However, insufficient data sample and unbalanced samples in each class have caused a poor accuracy. To make improvement the test accuracy, data augmentation and transfer learning are applied. Recently developed deep learning framework based on mathematical morphology …

Electric Field Induced Self-Assembly Of Mesoscale Structured Materials And Smart Fluids, Suchandra Das

Dissertations

This dissertation aims to study the forces that drive self-assembly in binary mixtures of particles suspended in liquids and on fluid-liquid interfaces when they are subjected to a uniform electric or magnetic field. Three fluid-particle systems are investigated experimentally and theoretically : (i) Suspensions of dielectric particles in dielectric liquids; (ii) Suspensions of ferromagnetic and diamagnetic particles in ferrofluids; and (iii) Dielectric particles on dielectric fluid-liquid interfaces. The results of these studies are then used to estimate the parameter values needed to assemble materials with desired mesoscale microstructures.

The first fluid-particle system studied is an electrorheological (ER) fluid formed using …

Fluorine-Based Inorganic Oxidizers For Use In Metal-Based Reactive Materials, Siva Kumar Valluri

Dissertations

This work explores inorganic fluorides as oxidizers for fuel-rich reactive materials. A preliminary assessment of metal fluorides accounting for their enthalpy of formation points to bismuth (III) fluoride, BiF3 and cobalt (II) fluoride, CoF2 as oxidizers of interest. Initially, composite powders of aluminum with chosen fluorides at 50-50 wt. % are prepared by arrested reactive milling. Despite an increase in reactivity and lowtemperature ignition, the prepared composite powders are insensitive to initiation by electro-static discharge (ESD), making them attractive alternative to analogous thermites having very high ESD sensitivity. In air, the composite powder particles burn faster than reference aluminum particles …

Private Sound Environments In Public Space: Use Of Headphones In Public Parks And Public Transit, Chathurthi S. De Silva

Dissertations

The use of headphones is now so commonplace that it is almost second nature for many people to use them. Not only do these people use headphones all the time, but they use them nearly everywhere, including in urban public spaces. In using headphones, people create their own “private sound environments” in public space. This phenomenon merits attention from researchers since the creation of private sound environments may well alter people’s experiences of public space.

This study answers five research questions about the use of headphones in parks and on transit: why people use them, when they begin using headphones …

Plant-Derived Extracellular Matrix Mimetic Scaffolds For Bone Repair Applications, Jessica Cardenas Turner

Dissertations

Autologous and allogeneic bone grafts are currently used to treat large bone defects or fractures that will not heal. However, for patients with osteoporosis or other conditions that impair the natural bone healing process, such as diabetes, smoking, bed rest, aging, autologous bone graft, which is the patient's own bone, is limited in quantity and its healing potential may be compromised. Allograft bone, or donated bone, lacks the necessary biological activity and has poor integration into defect. There is an urgent need for constructs/grafts capable of promoting bone cell function in fracture healing and large bone defects where the endogenous …

Controlled Reduction Of Graphene Oxide And Graphene Oxide-Carbon Nanotube Hybrids And Their Applications, Samar Azizighannad

Dissertations

Graphene and graphene derivatives are widely used in diverse research and industrial applications. Graphene production on a large scale is carried out by exfoliating graphite oxide and producing graphene oxide (GO), which comprises of graphene sheets with different oxygen-containing functional groups such as hydroxyl, carboxyl, and carbonyl. GO is reduced to reduced graphene oxide (rGO), which has properties that are closer to graphene. Properties of GO and rGO depend upon the oxygen content, and the effect of reducing oxygen content on the aqueous behavior of rGOs is not well understood.

In an effort to understand how properties of rGO change …

Modeling And Analysis Of Intracellular Signaling Networks And Cellular Decisions, Mustafa Ozen

Dissertations

Developing molecular network analysis methods is important due to their applications on complex biological systems such as target discovery, development of drugs, discovering drug effects, and finding treatments for many complex diseases, e.g., cancer, autoimmune, and mental disorders. An example of analysis techniques is the fault diagnosis analysis, in which the purpose is to quantify how much vulnerable the entire network is to dysfunction of one or multiple molecules. Such analysis can be done after proper network models are implemented, trained, and tested against the experimental data. In this dissertation, a Boolean modeling framework is implemented and methods to train …

Heparan Sulfate Proteoglycan Glypican‑1 And Pecam‑1 Cooperate In Shear‑Induced Endothelial Nitric Oxide Production, Anne Marie W. Bartosch, Rick Mathews, Marwa M. Mahmoud, Limary M. Cancel, Zahin S. Haq, John M. Tarbell

Publications and Research

This study aimed to clarify the role of glypican-1 and PECAM-1 in shear-induced nitric oxide production in endothelial cells. Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye. Glypican-1 pulling for 30 min stimulated nitric oxide production while PECAM-1 pulling did not. However, PECAM-1 downstream activation was necessary for the glypican-1 force-induced response. Glypican-1 knockout mice exhibited impaired flow-induced phosphorylation of eNOS without changes to PECAM-1 expression. A cooperation mechanism for the mechanotransduction of fluid shear stress …

The Effects Of Design Parameters On The Neural Recordings With Micro-Ecog Arrays, Manan Amish Sethia

Theses

In the field of neural prosthetics, electro-cortico-graph (ECoG) arrays are commonly used to record neural activity of the brain cortex both in animal and human subjects. A finite element model (FEM) was developed to simulate the electric field generated by a single neuron in the rat brain cortex and a micro ECoG array (µECoG) placed on the pia surface for recording the neural signal. The neuron was simulated as a dipole current source with a magnitude of 1µA and placed at three different depths in the motor cortex corresponding to different layers under the µECoG array. The array design was …

Numerical Study On Oscillating Flow Over A Flat Plate Using Pseudo-Compressibility In Intermittent Turbulent Regime, Shivank Srivastava Mr.

LSU New Orleans Theses and Dissertations

A Computational Fluid Dynamic (CFD) in-house code is developed to study unsteady characteristics of incompressible oscillating boundary layer flow over a flat plate under laminar and intermittently turbulent condition using pseudo-compressible unsteady Reynolds Averaged Navier- Stokes (RANS) model. In the in-house code, the two-dimensional, unsteady conservation of mass and momentum equations are discretized using finite difference techniques which employs second order accurate (based on Taylor series) central differencing for spatial derivatives and second order Runge-Kutta accurate differencing for temporal derivatives. The in-house code employs Fully Explicit-Finite Difference technique (FEFD) to solve the governing differential equations of the mathematical model. In …