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Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedi Dorcheh, Ali Akbari, Esmaiel Jabbari

Faculty Publications

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug clearance. Antibodies and ligands targeting the unique factors that maintain the niche are utilized …

Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedu Dorcheh, Ali Akbari, Esmaiel Jabbari

Faculty Publications

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug clearance. Antibodies and ligands targeting the unique factors that maintain the niche are utilized …

Preparation And Characterization Of Single Layer Conducting Polymer Electrochromic And Touchchromic Devices, Sharan Kumar Indrakar

USF Tampa Graduate Theses and Dissertations

Electrochromic devices (ECDs) have triggered great interest because of their potential applicability in energy-efficient buildings and low power display systems, including reflective type smart windows/mirrors and wearable-flexible devices. In the past decades, electrochromic technologies with different device structures and materials have been proposed. The idea of employing a simple device structure with a durable, cost effective electrolyte is crucial to designing and manufacturing high-performance ECDs. With this idea in mind, this thesis describes the various efforts to develop a simple ECD comprising of a composite single active layer gel electrolyte, sandwiched between two transparent conducting electrodes, lasting over 10,000 cycles …

Secure Vlsi Hardware Design Against Intellectual Property (Ip) Theft And Cryptographic Vulnerabilities, Matthew Dean Lewandowski

USF Tampa Graduate Theses and Dissertations

Over the last two decades or so, VLSI hardware is increasingly subject to sophisticated attacks on both the supply chain and design fronts. There is no explicit trust that the manufacturers/providers are not producing counterfeit designs or that cryptographic algorithms we know to be secure in software are also secure in hardware. The novelty and key contributions of this work are as follows: 1) a continually refined method for Intellectual Property (IP) Protection that provides an approach for verification of IP ownership, 2) demonstrate how to break the PRESENT-80 cryptographic algorithm with significantly limited resources, and 3) provide a multitude …

Advanced Organic Polymers For The Nanoscale Fabrication Of Fiber-Based Electronics Using The Electrospinning Technique, William Serrano Garcia

USF Tampa Graduate Theses and Dissertations

Electrospinning has become one of the most interesting techniques for fabricating nanofibers for multiple applications. The high surface-to-volume ratio nanofibers offer make the perfect structure for filters, sensors, and fiber-based electronics that could lead to a wide range of flexible electronics applications. This technique makes organic semiconducting polymers a promising alternative for single fiber electronics structures. Indeed, a wide variety of structures can be fabricated using electrostatic techniques for polymer manipulation from droplets, fibers, and coaxial structures. Although techniques such as electrospinning led the use of electrostatic forces to generate fibers of a precursor solution, electrospinning requires large enough polymer …

Biochar Amended Bioretention Systems For Nutrient And Fecal Indicator Bacteria Removal From Urban And Agricultural Runoffs, Md Yeasir Arif Rahman

USF Tampa Graduate Theses and Dissertations

Excessive nitrogen and fecal indicator bacteria (FIB) in stormwater runoff from urban areas or dairy farm operations impair water bodies resulting algal blooms, gastrointestinal illness, and economic losses. Recent advancements in stormwater management, including low impact development (LID) techniques, have provided engineers with a variety of tools to use in place of traditional catch basins and retention ponds. One promising LID technology for runoff management is bioretention, which consists of a shallow depression containing engineered porous media and vegetation. Prior studies have shown that modified bioretention systems that include an internal water storage zone (IWSZ) to promote denitrification can improve …

Traveling Wave Solutions For Two Species Competitive Chemotaxis Systems, T. B. Issa, R. B. Salako, W. Shen

Faculty Research, Scholarly, and Creative Activity

In this paper, we consider two species chemotaxis systems with Lotka–Volterra competition reaction terms. Under appropriate conditions on the parameters in such a system, we establish the existence of traveling wave solutions of the system connecting two spatially homogeneous equilibrium solutions with wave speed greater than some critical number c∗. We also show the non-existence of such traveling waves with speed less than some critical number c∗0 , which is independent of the chemotaxis. Moreover, under suitable hypotheses on the coefficients of the reaction terms, we obtain explicit range for the chemotaxis sensitivity coefficients ensuring c∗ = c∗0 , which …

Application Of Synthetic Aperture Radar Interferometry To Monitor Surface Deformations Of The Trans-European Transport Network (Ten-T) – A Case Study Of The Motorways Crossing Areas Of Mining Operations In The Upper Silesian Coal Basin, Poland, Adam Smoliński, Mariusz Stawinoga, Tomasz Pindel

Journal of Sustainable Mining

Underground hard coal mining causes surface deformations. When the mining operations are conducted beneath linear objects, such as motorways, there is a risk of deformations of the axis of the road and its horizontal and vertical alignment (additional bends and vertical curvatures, longitudinal inclinations, deformations of crosssections). In the areas subjected to mining operations, mining plants conduct geodetic monitoring. Due to their labour intensity and costs, geodetic measurements are usually made only a few times a year. The article discusses the possibility of applying Interferometric Synthetic Aperture Radar (InSAR) to monitor the subsidence of the vertical alignment of motorways caused …

Stream Sediment Monitoring In Morehead Kentucky, Kristopher Krolikowski, Jen O'Keefe

2021 Celebration of Student Scholarship - Oral Presentations

Sediment loads in stream systems play a big role in how overall runoff behaves. Streams naturally transport sediment at various ratios depending on precipitation. When vegetation is removed in upstream environments, sediment loads on streams increase. Sudden increases of sediments in streams can cause many issues, such as flooding or stream re-direction. In Morehead, KY, large-scale logging operations on the ridge above Knapp Avenue and on the ridge above the north end of Allen Avenue have caused increased sediment load in a small stream called Oxley Branch. This stream flows south parallel to Knapp Avenue and along the eastern property …

Department Of Chemical Engineering, Newsletters Volume 1 July 2021, Balakrishna K. Prabhu Dr

Faculty work

No abstract provided.

Computational Frameworks For Multi-Robot Cooperative 3d Printing And Planning, Laxmi Prasad Poudel

Graduate Theses and Dissertations

This dissertation proposes a novel cooperative 3D printing (C3DP) approach for multi-robot additive manufacturing (AM) and presents scheduling and planning strategies that enable multi-robot cooperation in the manufacturing environment. C3DP is the first step towards achieving the overarching goal of swarm manufacturing (SM). SM is a paradigm for distributed manufacturing that envisions networks of micro-factories, each of which employs thousands of mobile robots that can manufacture different products on demand. SM breaks down the complicated supply chain used to deliver a product from a large production facility from one part of the world to another. Instead, it establishes a network …

Tribological Studies Of Thick Polytetrafluoroethylene Coatings Enhanced By Polydopamine And Nanoparticles, Sujan Kumar Ghosh

Graduate Theses and Dissertations

Polytetrafluoroethylene (PTFE) is a popular low friction solid lubricant with high chemical and thermal stability. Thick PTFE coatings have the potential for many tribological applications, such as replacing Tin-based Babbitt materials in journal bearings. However, the weak bonding strength to the substrate and the high wear rate of PTFE coatings are current limiting factors. The lack of understanding of their tribological properties and wear mechanisms in oil-lubricated conditions and how coating thickness affects the tribological performance further hindered the use of PTFE coatings. In this dissertation, polydopamine (PDA), a bio-inspired adhesive, is used as an underlayer for or as a …

Influence Of Extracellular Matrix Stiffness And Topography On Neuronal Cell Behavior And Neurite Outgrowth, Mohan Yasodharababu

Graduate Theses and Dissertations

The focus of regeneration therapy for traumatic brain injuries and Alzheimer's disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing neuronal cell growth. A computational model can be used to decouple individual factors and study them individually to gain a better understanding of the mechanics between the neuronal cell and ECM, which will aid in the design of in vitro experimental studies.

This study develops …

Effects Of Memristive Synapse Radiation Interactions On Learning In Spiking Neural Networks, Sumedha Gandharava Dahl, Robert C. Ivans, Kurtis D. Cantley

Electrical and Computer Engineering Faculty Publications and Presentations

This study uses advanced modeling and simulation to explore the effects of external events such as radiation interactions on the synaptic devices in an electronic spiking neural network. Specifically, the networks are trained using the spike-timing-dependent plasticity (STDP) learning rule to recognize spatio-temporal patterns (STPs) representing 25 and 100-pixel characters. Memristive synapses based on a TiO₂ non-linear drift model designed in Verilog-A are utilized, with STDP learning behavior achieved through bi-phasic pre- and post-synaptic action potentials. The models are modified to include experimentally observed state-altering and ionizing radiation effects on the device. It is found that radiation interactions tend …

The Influence Of Participation In A Multi-Disciplinary Collaborative Service Learning Project On The Effectiveness Of Team Members In A 100-Level Mechanical Engineering Class, Stacie I. Ringleb, Pilar Pazos, Julia Noginova, Francisco Cima, Orlando Ayala, Krishnanand Kaipa, Jennifer Kidd, Kristie Gutierrez

Mechanical & Aerospace Engineering Faculty Publications

Engineers need to develop professional skills, including the ability to work successfully in teams and to communicate within and outside of their discipline, in addition to required technical skills. A collaborative multi-disciplinary service learning project referred to as Ed+gineering was implemented in a 100-level mechanical engineering course. In this collaboration, mechanical engineering students, primarily in the second semester of their freshman year or first semester of their second year, worked over the course of a semester with education students taking a foundations course to develop and deliver engineering lessons to fourth or fifth graders. Students in comparison engineering classes worked …

Application Of Gis And Multi-Criteria Statistical Techniques In Assessing Water Quality In The Coastal Province Of Vietnamese Mekong Delta, Giao Thanh Nguyen, Thi Hong Nhien Huynh

Applied Environmental Research

The study was conducted to evaluate the quality and spatial distribution of surface water quality in Soc Trang, a coastal province using Geographic information system (GIS) and multivariate statistical analysis. Water monitoring data was collected from 19 sampling locations with 19 parameters were analyzed from February 2019 to August 2020. The results indicated that water quality was contaminated with organic matters, nutrients, coliforms and salinity. Water quality index (WQI=22–73) indicated that water quality was from poor to medium level. Cluster analysis (CA) classified 19 monitoring sites into 7 groups and 19 months into 3 seasons including rainy season, rainy season-early …

Adsorption Of Methylene Blue By Low-Cost Biochar Derived From Elephant Dung, Yanasinee Suma, Nittaya Pasukphun, Numfon Eaktasang

Applied Environmental Research

Elephant dung biochar (ED350) prepared by controlled heating at 350 ºC was used to adsorb methylene blue (MB) in an aqueous solution. The effects of adsorption time, pH, adsorbent dosage, and initial MB concentration were examined. Kinetic, isotherm, and thermo-dynamic models were then further analyzed to determine the adsorption. The results show that ED350 was found to be efficient within 180 min. The optimum pH of MB adsorption was 11. The Langmuir isotherm model was found to be the most suitable fit for the adsorption equilibrium data, with ED350 having a homogeneous surface. The calculated equilibrium parameter (RL) …

Evaluation Of Liquid Deicing Materials For Winter Maintenance Applications, Erin Lammers-Staats

Kentucky Transportation Center Research Report

Winter weather can often pose difficulties for transportation agencies as they work to clear roads of snow and ice quickly so that motorists can travel safely and efficiently. Kentucky has made efforts to maximize efficiency within its winter maintenance program by focusing on optimized equipment usage and personnel time management. In this study, KYTC evaluated anti-icers and how their performance compared to the current performance of brine and calcium chloride mixture. New brine additives claim to offer better results, but there is very little guidance about how to systematically evaluate new anti-icers. Researchers were tasked with developing a testing methodology …

Grammatical Evolution For Detecting Cyberattacks In Internet Of Things Environments, Hasanen Alyasiri, John Clark, Ali Malik, Ruairí De Fréin

Conference papers

The Internet of Things (IoT) is revolutionising nearly every aspect of modern life, playing an ever greater role in both industrial and domestic sectors. The increasing frequency of cyber-incidents is a consequence of the pervasiveness of IoT. Threats are becoming more sophisticated, with attackers using new attacks or modifying existing ones. Security teams must deal with a diverse and complex threat landscape that is constantly evolving. Traditional security solutions cannot protect such sys- tems adequately and so researchers have begun to use Machine Learning algorithms to discover effective defence systems. In this paper, we investigate how one approach from the …

Nanomaterial-Based Biosensors For Detection Of Salmonella Typhimurium And Avian Influenza Virus H5n1 In Poultry, Xinge Xi

Graduate Theses and Dissertations

This research focused on developing biosensing method and biosensing device for rapid detection of pathogens in poultry: Salmonella Typhimurium and avian influenza virus H5N1. The first part of the dissertation reports an original research on the development of a portable biosensing device for Salmonella detection. The device was designed and constructed based on a previously developed optical biosensing method, using immuno-magnetic nanoparticles to specifically capture target bacteria, and immuno-quantum dot beads to label the target bacteria for fluorescence detection. All the actions of sample mixing, magnetic separation, and fluorescence detection were controlled automatically in a disposable microfluidic chip in the …

Synthesis And Performance Testing Of Ecm Fiber Scaffolds, Cassandra Reed

Graduate Theses and Dissertations

The progression of regenerative medicine has advanced the treatment of multiple illnesses and injuries throughout the years. A good example of the benefits of this research is the work that has gone into volumetric muscle loss (VML), where more than 20% of the muscle is loss. Skeletal muscle makes up 40% of the human body so a loss of that size greatly diminishes the strength, the flexibility, physiology, and quality of life of the injured individual. For that reason, various techniques are used to counteract the loss of structure and innate cellular signaling in order to circumvent that from happening. …

Investigation Of Iron-Nickel Based Nanoparticles As Catalysts For Oxygen Evolution Reaction (Oer), Prashant Acharya

Graduate Theses and Dissertations

Hydrogen fuel is increasingly seen as an appealing alternative by both the scientific and the industrial communities in the drive towards a clean energy future. Hydrogen, unlike fossil-based fuels, does not release carbon dioxide, a chief component of greenhouse gases, upon combustion. However, more than 95% of the hydrogen in the world is still produced by burning fossil fuels as this method is currently the only economically feasible option at a large industrial scale.

Water electrolysis shows a lot of potential in both hydrogen generation and in the storage of energy from renewable sources such as wind and sunlight. Likewise, …

Forecasting Stock Exchange Data Using Group Method Of Data Handling Neural Network Approach, Marzieh Faridi Masouleh, Ahmad Bagheri

Knowledge Engineering and Data Science

The increasing uncertainty of the natural world has motivated computer scientists to seek out the best approach to technological problems. Nature-inspired problem solving approaches include meta-heuristic methods that are focused on evolutionary computation and swarm intelligence. One of these problems significantly impacting information is forecasting exchange index, which is a serious concern with the growth and decline of stock as there are many reports on loss of financial resources or profitability. When the exchange includes an extensive set of diverse stock, particular concepts and mechanisms for physical security, network security, encryption, and permissions should guarantee and predict its future needs. …

Arhgdia Confers Selective Advantage To Dissociated Human Pluripotent Stem Cells, Marion J. Riggs, Steven D. Sheridan, Raj R. Rao

Biomedical Engineering Faculty Publications and Presentations

Human pluripotent stem cells (hPSCs) have generated significant interest in the scientific community based on their potential applications in regenerative medicine. However, numerous research groups have reported a propensity for genomic alterations during hPSC culture that poses concerns for basic research and clinical applications. Work from our laboratory and others has demonstrated that amplification of chromosomal regions is correlated with increased gene expression. To date, the phenotypic association of common genomic alterations remains unclear and is a cause for concern during clinical use. In this study, we focus on trisomy 17 and a list of candidate genes with increased gene …

Response-To-Failure Analysis Of Global Food System Initiatives: A Resilience Perspective, Prince Agyemang, Ebenezer Miezah Kwofie

Biological and Agricultural Engineering Faculty Publications and Presentations

International food system initiatives have led the efforts to combat the threats to global food security resulting from the failure of the current food systems. This study set out to investigate and assess the contributions of global food system initiatives in tackling the food system challenges. In assessing the food system initiatives, we develop a three-step methodology for Food System Initiative (FSI) selection and then conduct a qualitative evaluation using relevant indicators based on food system failure narratives. Furthermore, the authors synthesize present literature in the context of the extent to which coronavirus disease 2019 (COVID-19) pandemic has compounded food …

Scheduling Allocation And Inventory Replenishment Problems Under Uncertainty: Applications In Managing Electric Vehicle And Drone Battery Swap Stations, Amin Asadi

Graduate Theses and Dissertations

In this dissertation, motivated by electric vehicle (EV) and drone application growth, we propose novel optimization problems and solution techniques for managing the operations at EV and drone battery swap stations. In Chapter 2, we introduce a novel class of stochastic scheduling allocation and inventory replenishment problems (SAIRP), which determines the recharging, discharging, and replacement decisions at a swap station over time to maximize the expected total profit. We use Markov Decision Process (MDP) to model SAIRPs facing uncertain demands, varying costs, and battery degradation. Considering battery degradation is crucial as it relaxes the assumption that charging/discharging batteries do not …

Interrelation Of Thermal Stimulation With Haptic Perception, Emotion, And Memory, Mehdi Hojatmadani

USF Tampa Graduate Theses and Dissertations

Haptics is an interdisciplinary field of science that deals with how humans perceive and respond to different sensory cues perceived through touch. Thermal haptics as a branch deals with how humans perceive the temperature sensation and respond to that. The process in which thermal perception occurs is well known to researchers. What seems missing in the literature is how temperature interacts or sometimes intervenes in other physiological and psychological aspects of our lives. In this research, a series of studies are presented where the main focus was how temperature and brain interact with each other to impede or enhance our …

Investigation Of Polymer-Plasticizer Blends For Btex Detection Using Quartz Crystal Microbalance, Abhijeet Iyer

USF Tampa Graduate Theses and Dissertations

Volatile organic compounds (VOCs) are chemicals that evaporate easily and become gases at ambient temperature and pressure. The EPA has made the monitoring of VOCs mandatory due to their health impacts, which range from headaches and nausea to cancer. The current techniques used for VOC monitoring such as photoionization, gas chromatography, mass spectroscopy, and e-noses sensors are expensive, time-intensive, demand rigorous sample preparation, and cannot quantify the VOCs in the air. Chemical sensors based on piezoelectric transduction like the quartz crystal microbalance (QCM) show promising results in terms of providing cost-effective real-time data, robustness, and low power requirements. In this …

Gaze Estimation And Tracking For Assisted Living Environments, Paris Her

Master's Theses (2009 -)

Assisted living environments must be able to efficiently and unobtrusively gather information on a person's well-being. Human gaze direction provides some of the strongest indicators of how a person behaves and interacts with their environment. To that end, this thesis proposes a gaze tracking method that uses a neural network regressor to estimate gaze direction from facial keypoints and integrates them over time using various temporal methods, specifically through moving averages and a Kalman filter. Our gaze regression model uses confidence gated units to handle cases of keypoint occlusion and is able to estimate its own prediction uncertainty. This approach …

The Effects Of Noise On Parametrically Excited Systems With Nonlinear Damping, Donghao Li

Theses and Dissertations

Parametric oscillators are a class of resonating systems in which a parameter, such as stiffness in a mechanical system or capacitance in an electrical system, is periodically modulated in order to alter the system response in a desired manner. A resonance effect occurs when the pump frequency is near twice of resonant frequency. Such systems are said to be “parametrically pumped,” and this pump can, above a certain amplitude threshold, destabilize the system in the absence of nonlinearities. Parametric resonance is widely observed in nature and has been employed in a large variety of engineered systems, most notably in micro-electro-mechanical …