Digital Commons Network^™

Understanding Effects Of Permafrost Degradation And Coastal Erosion On Civil Infrastructure In Arctic Coastal Villages: A Community Survey And Knowledge Co-Production, Min Liew, Ming Xiao, Louise Farquharson, Dmitry Nicolsky, Anne Jensen, Vladimir Romanovsky, Jana Peirce, Lilian Alessa, Christopher Mccomb, Xiong Zhang, Benjamin Jones

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This paper presents the results of a community survey that was designed to better under-stand the effects of permafrost degradation and coastal erosion on civil infrastructure. Observations were collected from residents in four Arctic coastal communities: Point Lay, Wainwright, Utqiaġvik, and Kaktovik. All four communities are underlain by continuous ice-rich permafrost with varying degrees of degradation and coastal erosion. The types, locations, and periods of observed permafrost thaw and coastal erosion were elicited. Survey participants also reported the types of civil infrastructure being affected by permafrost degradation and coastal erosion and any damage to residential buildings. Most survey participants reported …

Narrative Analysis Of Open-Source Social Media Activity In The Indopacom Aor, Aaron K. Glenn

Theses and Dissertations

Emotion classification can be a powerful tool to derive narratives from social media data. Recurrent Neural Networks (RNN) can meet or exceed the performance of state-of-the-art traditional machine learning techniques using exclusively open-source data and models. Specifically, these results show that RNN variants can produce more than an 8% gain in accuracy in comparison to Logistic Regression and SVM techniques and a 15% gain over Random Forest when using FastText embeddings. This research found a statistical significance in the performance of a single layer Bi-directional Long Short-Term Memory (Bi-LSTM) model over a 2-layer stacked Bi-LSTM model. This research also found …

A New Approach To Career Field Matching For Commissioning Air Force Cadets, Daniel Griffen Laird

Theses and Dissertations

The current method of assigning graduating cadets from the United States Air Force Academy and Reserve Officers' Training Corps (ROTC) detachments to their career fields uses an integer programming model to maximize \global" Air Force utility, subject to several Air Force-defined constraints. This utility evaluates the positive benefit of assigning a certain cadet to a certain career field. This paper discusses the issues with such a model, as well as presents a new, more refined approach to the problem. Rather than provide a one-size-fits-all formulation of this particular assignment problem, a Value-Focused Thinking (VFT) framework is applied, in conjunction with …

Simultaneous Actuation And Sensing Of Electrostatic Mems, Jacob E. Song

Theses and Dissertations

Micro-Electro-Mechanical Systems (MEMS) are devices that play important roles of sensing and actuation in many different industries including automation, electronics, medical, communications, and defense. In order to make full use of these devices, it is important to understand the peripherals that enable these devices. Simultaneous actuation and control of MEMS devices is an important area of research as it enables feedback control of these device and allows devices to maintain performance as devices depreciate over their lifetime. The aim of this thesis is to perform a design space analysis on an electrostatic MEMS simultaneous actuation and sensing circuit that is …

Team Air Combat Using Model-Based Reinforcement Learning, David A. Mottice

Theses and Dissertations

We formulate the first generalized air combat maneuvering problem (ACMP), called the MvN ACMP, wherein M friendly AUCAVs engage against N enemy AUCAVs, developing a Markov decision process (MDP) model to control the team of M Blue AUCAVs. The MDP model leverages a 5-degree-of-freedom aircraft state transition model and formulates a directed energy weapon capability. Instead, a model-based reinforcement learning approach is adopted wherein an approximate policy iteration algorithmic strategy is implemented to attain high-quality approximate policies relative to a high performing benchmark policy. The ADP algorithm utilizes a multi-layer neural network for the value function approximation regression mechanism. One-versus-one …

Analyzing The Impact Of Blood Transfusion Kits And Triage Misclassification Errors For Military Medical Evacuation Dispatching Policies Via Approximate Dynamic Programming, Channel A. Rodriguez

Theses and Dissertations

Members of the armed forces greatly rely on having an effective and efficient medical evacuation (MEDEVAC) process for evacuating casualties from the battlefield to medical treatment facilities (MTF) during combat operations. This thesis examines the MEDEVAC dispatching problem and seeks to determine an optimal policy for dispatching a MEDEVAC unit, if any, when a 9-line MEDEVAC request arrives, taking into account triage classification errors and the possibility of having blood transfusion kits on board select MEDEVAC units. A discounted, infinite-horizon continuous-time Markov decision process (MDP) model is formulated to examine such problem and compare generated dispatching policies to the myopic …

Analysis Of Generalized Artificial Intelligence Potential Through Reinforcement And Deep Reinforcement Learning Approaches, Jonathan Turner

Theses and Dissertations

Artificial Intelligence is the next competitive domain; the first nation to develop human level artificial intelligence will have an impact similar to the development of the atomic bomb. To maintain the security of the United States and her people, the Department of Defense has funded research into the development of artificial intelligence and its applications. This research uses reinforcement learning and deep reinforcement learning methods as proxies for current and future artificial intelligence agents and to assess potential issues in development. Agent performance were compared across two games and one excursion: Cargo Loading, Tower of Hanoi, and Knapsack Problem, respectively. …

Global Sporadic-E Climatological Analysis Using Gps Radio Occultation And Ionosonde Data, Travis J. Hodos

Theses and Dissertations

A climatology of sporadic-E (Es) derived from a combined data set of GPS radio occultation (GPS-RO) and ground-based ionosonde soundings is presented for the period from September 2006 to February 2019. The ionosonde soundings were measured using the Lowell Digisonde International (LDI) Global Ionosphere Radio Observatory (GIRO) network consisting of 65 sites and 13,141,060 total soundings. The GPS-RO observations were taken aboard the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellites and processed using two binary Es detection algorithms, totaling 9,072,922 occultations. The first algorithm is an S4 amplitude threshold calibrated to the occurrence of any blanketing Es …

Analysis Of Microscopic Carbon Fiber Fragments, Zachary R. Scott

Theses and Dissertations

Carbon Fiber (CF) has different tensile strengths and transverse moduli depending on how they are fabricated. Some CF is export controlled as it can be used for weapons, spacecraft, or gas centrifuges for enriching nuclear fuel. This research project explored a new way to prepare micron sized single CF threads to measure their transverse modulus and compare the moduli of non-export controlled CF to that of an export controlled CF. Five total polyacrylonitrile (PAN) fibers were used in this project, one of which was an export controlled fiber.

Targeting Hif-2Α In The Tumor Microenvironment: Redefining The Role Of Hif-2Α For Solid Cancer Therapy., Leah Davis, Matthias Recktenwald, Evan Hutt, Schuyler Fuller, Madison Briggs, Arnav Goel, Nichole Daringer

Henry M. Rowan College of Engineering Departmental Research

Inadequate oxygen supply, or hypoxia, is characteristic of the tumor microenvironment and correlates with poor prognosis and therapeutic resistance. Hypoxia leads to the activation of the hypoxia-inducible factor (HIF) signaling pathway and stabilization of the HIF-α subunit, driving tumor progression. The homologous alpha subunits, HIF-1α and HIF-2α, are responsible for mediating the transcription of a multitude of critical proteins that control proliferation, angiogenic signaling, metastasis, and other oncogenic factors, both differentially and sequentially regulating the hypoxic response. Post-translational modifications of HIF play a central role in its behavior as a mediator of transcription, as well as the temporal transition from …

Novel Stimuli-Responsive Pectin-Pvp-Functionalized Clay Based Smart Hydrogels For Drug Delivery And Controlled Release Application, Shabnam Rehmat, Nayab Batool Rizvi, Saba Urooge Khan, Abdul Ghaffar, Atif Islam, Rafi Ullah Khan, Azra Mehmood, Hira Butt, Muhammad Rizwan

Michigan Tech Publications, Part 1

Stimuli-responsive drug delivery systems are urgently required for injectable site-specific delivery and release of drugs in a controlled manner. For this purpose, we developed novel pH-sensitive, biodegradable, and antimicrobial hydrogels from bio-macromolecule pectin, polyvinylpyrrolidone (PVP), 3-aminopropyl (diethoxy)methyl silane (3-APDEMS), and sepiolite clay via blending and solution casting technique. The purified sepiolite (40 um) was functionalized with 3-APDEMS crosslinker (ex-situ modification) followed by hydrogels fabrication. FTIR and SEM confirmed crosslinked structural integrity and rod-like morphology of hydrogels respectively. The swelling properties of hydrogels could be controlled by varying the concentration of modified clay in pectin/PVP blends. Moreover, the decrease in pH …

Plant Protein-Based Food Packaging Films; Recent Advances In Fabrication, Characterization, And Applications, Milad Hadidi, Shima Jafarzadeh, Mehrdad Forough, Farhad Garavand, Saeid Alizadeh, Ali Salehabadi, Amin Mousavi Khaneghah, Seid Mahdi Jafari

Research outputs 2022 to 2026

Background: Plant-based proteins as an alternative to synthetic polymers have attracted the interest of the global packaging industry in the last decade due to their biodegradability, sustainability, environmental, and beneficial health claims.

Scope and approach: This review covers the recent developments in biodegradable packaging such as edible films/coatings and innovative packaging materials based on plant protein sources. The importance, sources, and techno-functional properties of plant-derived proteins for food packaging are discussed. The impact of different additives on the functionality of plant protein-based biodegradable materials is also investigated. In addition, plant protein-based packaging characteristics and their application in food are also …

Decellularized Articular Cartilage Microgels As Microcarriers For Expansion Of Mesenchymal Stem Cells, Esmaiel Jabbari, Azadeh Sepahvandi

Faculty Publications

Conventional microcarriers used for expansion of human mesenchymal stem cells (hMSCs) require detachment and separation of the cells from the carrier prior to use in clinical applications for regeneration of articular cartilage, and the carrier can cause undesirable phenotypic changes in the expanded cells. This work describes a novel approach to expand hMSCs on biomimetic carriers based on adult or fetal decellularized bovine articular cartilage that supports tissue regeneration without the need to detach the expanded cells from the carrier. In this approach, the fetal or adult bovine articular cartilage was minced, decellularized, freeze-dried, ground, and sieved to produce articular …

Decellularized Articular Cartilage Microgels As Microcarriers For Expansion Of Mesenchymal Stem Cells, Esmaiel Jabbari, Azadeh Sepahvandi

Faculty Publications

Conventional microcarriers used for expansion of human mesenchymal stem cells (hMSCs) require detachment and separation of the cells from the carrier prior to use in clinical applications for regeneration of articular cartilage, and the carrier can cause undesirable phenotypic changes in the expanded cells. This work describes a novel approach to expand hMSCs on biomimetic carriers based on adult or fetal decellularized bovine articular cartilage that supports tissue regeneration without the need to detach the expanded cells from the carrier. In this approach, the fetal or adult bovine articular cartilage was minced, decellularized, freeze-dried, ground, and sieved to produce articular …

Interactive Virtual Scanning Electron Microscope Inspired By 3d Game-Design, Pnina Ari-Gur, Igor Lapsker, Tyler Bayne, Eric Allen Pietrowicz, Peter Thannhauser, Spencer Hoin, Hermanu Joko Nugroho

Mechanical and Aerospace Engineering Faculty Publications

The scanning electron microscope (SEM) has evolved to become an indispensable tool for research and education in engineering, physics, nanotechnology, geosciences, materials science, biological sciences and other fields. However, training on a physical SEM is costly, time consuming, and often unavailable in economically disadvantaged areas. Advances in computer technology have made interactive three-dimensional (3D) virtual laboratory an effective tool for training in medicine and many engineering and technology fields. In the current work, in order to provide cost-effective hands-on training, a virtual 3D SEM was developed using the game development engine Unity 3D. It contains realistic 3D models of the …

Thermosensitive Polymers And Thermo-Responsive Liposomal Drug Delivery Systems, Waad H. Abuwatfa, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven to synergistically act to arrest tumor growth when combined with optimally-designed smart drug delivery systems (DDSs). Thermoresponsive DDSs aid in making the drugs more bioavailable, enhance the therapeutic index and pharmacokinetic trends, and provide the spatial placement and temporal delivery of the drug into localized anatomical sites. This paper reviews the fundamentals of thermosensitive polymers, with a particular focus on thermoresponsive liposomal-based drug delivery systems.

Coral Reef Restoration Monitoring Through An Environmental Engineering And Social-Ecological Lens, Michelle C. Platz

USF Tampa Graduate Theses and Dissertations

The Florida Reef Tract (FRT) has experienced catastrophic coral cover declines since the 1970s, and active coral restoration is therefore needed to recover ecosystem integrity, preserve intrinsic values, and guarantee the provision of ecosystem services on which humans rely. While the coral restoration field’s ability to grow and outplant coral has improved extensively in the last two decades, this growth has led to the development of research gaps pertaining to restoration monitoring, specifically regarding the technical capacity to perform long term monitoring, spatial and temporal resolution, and metrics with which to quantify changes in ecosystem function resulting from restoration. The …

Fourth-Order Comprehensive Adjoint Sensitivity Analysis Methodology For Nonlinear Systems (4th-Casam-N): I. Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work presents the fourth-order comprehensive sensitivity analysis methodology for nonlinear systems (abbreviated as “4th-CASAM-N”) for exactly and efficiently computing the first-, second-, third-, and fourth-order functional derivatives (customarily called “sensitivities”) of physical system responses (i.e., “system performance parameters”) to the system’s (or model) parameters. The qualifier “comprehensive” indicates that the 4th-CASAM-N methodology enables the exact and efficient computation not only of response sensitivities with respect to the customary model parameters (including computational input data, correlations, initial and/or boundary conditions) but also with respect to imprecisely known material boundaries, caused by manufacturing tolerances, of the system under consideration. The 4th-CASAM-N …

Cobalt Ferrite Nano-Composites For The Oxidation Of Phenols In Oil Refinery Wastewater, Amira Mohamed

Theses and Dissertations

Phenolic compounds have the tendency to persist in the environment over a long period making them a main source of concern because of their toxic characteristics towards humans and animals (Bruce et al., 1987). Therefore, existence of phenolic compounds in aquatic environment is unfavourable and as a result, many treatment techniques have been implemented to treat the wastewater produced from petroleum refineries. Petroleum refineries are among the top industries that produces significant quantities of high phenol concentration wastewater. Photo-catalysis is a promising and effective method to treat phenol present in oil refineries effluent. In this study, the photo-catalyst used is …

Deep-Precognitive Diagnosis: Preventing Future Pandemics By Novel Disease Detection With Biologically-Inspired Conv-Fuzzy Network, Aviral Chharia, Rahul Upadhyay, Vinay Kumar, Chao Cheng, Jing Zhang, Tianyang Wang, Min Xu

Computer Vision Faculty Publications

Deep learning-based Computer-Aided Diagnosis has gained immense attention in recent years due to its capability to enhance diagnostic performance and elucidate complex clinical tasks. However, conventional supervised deep learning models are incapable of recognizing novel diseases that do not exist in the training dataset. Automated early-stage detection of novel infectious diseases can be vital in controlling their rapid spread. Moreover, the development of a conventional CAD model is only possible after disease outbreaks and datasets become available for training (viz. COVID-19 outbreak). Since novel diseases are unknown and cannot be included in training data, it is challenging to recognize them …

Natural Biomaterial Honey-Based Resistive Switching Device For Artificial Synapse In Neuromorphic Systems, Brandon Sueoka, Kuan Yew Cheong, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

Resistive switching is a promising technology for artificial synapses, the most critical component and building block of a neural network for brain-inspired neuromorphic computing. The artificial synapse is capable of emulating a signal process and memory functions of biological synapses. The artificial synapse fabricated by natural bioorganic materials is essential for developing soft, flexible, and biocompatible electronics and sustainable, biodegradable, and environmentally friendly neuromorphic systems. In this work, a natural biomaterial - honey based resistive switching device - was demonstrated to emulate some important functionalities of biological synapses, including synaptic potentiation and depression, short-term and long-term memory, spatial summation, and …

Spatial And Temporal Variation Of Selected Water Quality Parameters In The Tanzanian Side Of Lake Victoria, Richard Joseph Kimwaga

Tanzania Journal of Engineering and Technology (TJET)

Lake Victoria’s water quality is increasingly becoming under heavy pressure mainly due to land based activities and aerial inputs which are taking place within the basin. This study was carried out to assess the spatial, including vertical and temporal, variation of the water quality of Lake Victoria on the Tanzanian side. Historical water quality data for the period from 2000 to 2016 was collected. Temperature, pH, Dissolved Oxygen (DO) and Turbidity were selected for study since they are the mostly measured and monitored water quality parameters. Land use-land cover changes were analysed using ArcGIS. ILWIS 3.7 software was used to …

Age Specific Models To Capture The Change In Risk Factor Contribution By Age To Short Term Primary Ischemic Stroke Risk, Elizabeth Hunter, John D. Kelleher

Articles

Age is one of the most important risk factors when it comes to stroke risk prediction. However, including age as a risk factor in a stroke prediction model can give rise to a number of difficulties. Age often dominates the risk score, and also not all risk factors contribute proportionally to stroke risk by age. In this study we investigate a number of common stroke risk factors, using Framingham heart study data from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center to determine if they appear to contribute proportionally by age to a stroke risk score. As we …

State Of Industry 5.0—Analysis And Identification Of Current Research Trends, Aditya Akundi, Daniel Euresti, Sergio Luna, Wilma Ankobiah, Amit Lopes, Immanuel Edinbarough

Manufacturing & Industrial Engineering Faculty Publications

The term Industry 4.0, coined to be the fourth industrial revolution, refers to a higher level of automation for operational productivity and efficiency by connecting virtual and physical worlds in an industry. With Industry 4.0 being unable to address and meet increased drive of personalization, the term Industry 5.0 was coined for addressing personalized manufacturing and empowering humans in manufacturing processes. The onset of the term Industry 5.0 is observed to have various views of how it is defined and what constitutes the reconciliation between humans and machines. This serves as the motivation of this paper in identifying and analyzing …

Biomechanical Evaluation Of Recurrent Dissociation Of Modular Humeral Prostheses, Daniel B. Luckenbill, Mike F. Iossi, Alyssa M. George Whitney, Danielle Miller, Lynn A. Crosby, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

The purpose of the study was to evaluate the force and torque required to dissociate a humeral head from the unimplanted modular total shoulder replacement system from different manufacturers and to determine if load and torque to dissociation are reduced in the presence of bodily fluids. Impingement, taper contamination, lack of compressive forces, and interference of taper fixation by the proximal humerus have all been reported as possible causes for dissociation. Experimental values determined in this research were compared with literature estimates of dissociation force of the humeral head under various conditions to gain more understanding of the causes of …

Micelles Inhibit Electro-Oxidation Degradation Of Nonylphenol Ethoxylates, Yangyuan Ji, Junfeng Niu, Yuhang Fang, Alliyan Tan Nou, David M. Warsinger

School of Mechanical Engineering Faculty Publications

Nonylphenol ethoxylates (NEPOs) are widely used as nonionic surfactant in the industry, which pose a threat to environment and human health. In this study, we conducted kinetic experiments and chemical analysis to investigate the effects of NEPOs micelles on degradation kinetics and electro-oxidation degradation mechanism. The electro-oxidation degradation of NEPOs followed pseudo-first order kinetics and more than 92% of NEPOs was degraded. Furthermore, the hydroxyl radicals generated by the Ti4O7 anode contributed to 41% of degradation performance. During the entire degradation process, the micelles of NEPOs undergo growth, and the steric hindrance phenomenon of micelles prevents NEPOs from being attack …

The Low Abundance Of Cpg In The Sars-Cov-2 Genome Is Not An Evolutionarily Signature Of Zap, Ali Afrasiabi, Hamid Alinejad-Rokny, Azad Khosh, Mostafa Rahnama, Nigel Lovell, Zhenming Xu, Diako Ebrahimi

Plant Pathology Faculty Publications

The zinc finger antiviral protein (ZAP) is known to restrict viral replication by binding to the CpG rich regions of viral RNA, and subsequently inducing viral RNA degradation. This enzyme has recently been shown to be capable of restricting SARS-CoV-2. These data have led to the hypothesis that the low abundance of CpG in the SARS-CoV-2 genome is due to an evolutionary pressure exerted by the host ZAP. To investigate this hypothesis, we performed a detailed analysis of many coronavirus sequences and ZAP RNA binding preference data. Our analyses showed neither evidence for an evolutionary pressure acting specifically on CpG …

Modification Of Superabsorbent Hydrogels For Industrial Wastewater Treatment, Md. Owaleur Rahman, Md. Abdul Halim, Anjan Deb, Shafi Ahmed, Md. Wasikur Rahman, N. C. Dafader, S. M. Nur Alam, Shahjalal Khandaker, Md. Jahangir Alam

Mechanical Engineering Faculty Publications

A breakthrough in superabsorbent hydrogel (SAH) preparation was studied in the current issue by blending potato starch and acrylic acid for wastewater treatment. Gamma irradiation source (60Co irradiation) was used to irradiate SAH from 1 to 10 kGy dose at room temperature (~27°C). The swelling ratio, water absorption, equilibrium water content, and gel fraction properties of the hydrogel were investigated. The as-prepared hydrogel treated with KOH (THG) showed excellent absorption capacity but less mechanical stability compared to untreated hydrogel (UHG). The gel fraction of treated SAH was slightly lower in methanol, but the utmost in water at 5 kGy infers …

Strategy For Conjugating Oligopeptides To Mesoporous Silica Nanoparticles Using Diazirine-Based Heterobifunctional Linkers, Md Arif Khan, Ramy W. Ghanim, Maelyn R. Kiser, Mahsa Moradipour, Dennis T. Rogers, John M. Littleton, Luke H. Bradley, Bert C. Lynn, Stephen E. Rankin, Barbara L. Knutson

Chemical and Materials Engineering Faculty Publications

Successful strategies for the attachment of oligopeptides to mesoporous silica with pores large enough to load biomolecules should utilize the high surface area of pores to provide an accessible, protective environment. A two-step oligopeptide functionalization strategy is examined here using diazirine-based heterobifunctional linkers. Mesoporous silica nanoparticles (MSNPs) with average pore diameter of ~8 nm and surface area of ~730 m²/g were synthesized and amine-functionalized. Tetrapeptides Gly-Gly-Gly-Gly (GGGG) and Arg-Ser-Ser-Val (RSSV), and a peptide comprised of four copies of RSSV (4RSSV), were covalently attached via their N-terminus to the amine groups on the particle surface by a heterobifunctional linker, …

Efficacy Of Softener For Enhancing Fatigue And Low-Temperature Performance Of Asphalt Binders With High Rap, Sumon Roy

Student Theses and Dissertations

The use of a higher percentage of reclaimed asphalt pavement (RAP) in asphalt concrete can lead to developing premature failure of asphalt pavements due to fatigue and/or low-temperature cracking. The incorporation of softening agents in asphalt binders can resolve these problems and enhance pavement durability. This study aims to evaluate the effectiveness of waste-based softening agents for enhancing the properties of asphalt mixes with high RAP contents. Waste cooking oil (WCO), and engine bottom oil (EBO) along with a commercial rejuvenator were investigated in this study. Three types of Performance Grade (PG) binders, each collected from two different sources, used …