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A Visual History Of Dining A Timeline, Eli Feldman Aug 2022

A Visual History Of Dining A Timeline, Eli Feldman

IntAR Interventions Adaptive Reuse

No abstract provided.


The Changing Roles Retail In The Experience Economy, Ann Petermans, Bie Plevoets, Koenraad Van Cleemopoel Aug 2022

The Changing Roles Retail In The Experience Economy, Ann Petermans, Bie Plevoets, Koenraad Van Cleemopoel

IntAR Interventions Adaptive Reuse

No abstract provided.


Approximations To A Working Space Around But Not Inside El Museo De Los Sures, Laura F. Gibellini Aug 2022

Approximations To A Working Space Around But Not Inside El Museo De Los Sures, Laura F. Gibellini

IntAR Interventions Adaptive Reuse

No abstract provided.


New Pasts, Old Experiences The Spectacle Of Authenticity At Cairo's Museum Of Agriculture, Samaa Elimam Aug 2022

New Pasts, Old Experiences The Spectacle Of Authenticity At Cairo's Museum Of Agriculture, Samaa Elimam

IntAR Interventions Adaptive Reuse

No abstract provided.


Thoughts On Space Science Development, Yidong Gu Aug 2022

Thoughts On Space Science Development, Yidong Gu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Space science is a large-scale activity by using space vehicles to explore the universe and natural laws and carry out special experiments, which has made great contributions to the development of contemporary science. This paper outlines the major breakthroughs in international space science, analyzes the context and new trends of space science and manned exploration activities, reviews the development achievements of space science in China in the past 20 years, puts forward existing problems and gaps, and emphasizes the strategic position of space science and its importance to China's science and technology, aerospace and the national long-term development. It is …


Connecting The Last Mile To Speed Up Space Science Development Of China—Review And Prospect Of The Funding Practices For Space Science By Nsfc, Zengqian Hou, Yupeng Yao, Guoxuan Dong, Sheng Yu Aug 2022

Connecting The Last Mile To Speed Up Space Science Development Of China—Review And Prospect Of The Funding Practices For Space Science By Nsfc, Zengqian Hou, Yupeng Yao, Guoxuan Dong, Sheng Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Strengthening the basic scientific research in an all-round way and achieving more breakthroughs from zero to one as soon as possible are the major strategic needs of building a world leading power in science and technology in the new era. As the main channel funding basic research in China, the National Natural Science Foundation of China (NSFC) has always focused on the basic frontiers and major scientific issues in space science, carried out strategic research on the planning of relevant disciplines, sorted out key scientific questions, defined the priority development direction, and provided continuous and stable funding through major, key, …


The Role Of Small Gtpases In Regulating Blood-Brain Barrier Mechanotransduction, Brandon Jude Deore Aug 2022

The Role Of Small Gtpases In Regulating Blood-Brain Barrier Mechanotransduction, Brandon Jude Deore

Theses and Dissertations

Fluid shear stress is an important mediator of vascular permeability, yet the molecular mechanisms underlying the effect of shear on the blood-brain barrier (BBB) have yet to be clarified in cerebral vasculature despite its importance for brain homeostasis.. Neurological symptoms including the formation of microclots, stroke, and other neurological pathologies associated with changes in cerebral blood flow are hallmarks of BBB dysfunction. The in vitro model used in this dissertation is compatible with real-time measurement of barrier function using a transendothelial electrical resistance as well as immunocytochemistry and dextran permeability assays. These experiments reveal that there is a threshold level …


The Missing Link Between Standing-And Traveling-Wave Resonators, Qi Zhong, Haoqi Zhao, Liang Feng, Kurt Busch, Sahin K. Özdemir, Ramy El-Ganainy Aug 2022

The Missing Link Between Standing-And Traveling-Wave Resonators, Qi Zhong, Haoqi Zhao, Liang Feng, Kurt Busch, Sahin K. Özdemir, Ramy El-Ganainy

Michigan Tech Publications, Part 1

Optical resonators are structures that utilize wave interference and feedback to confine light in all three dimensions. Depending on the feedback mechanism, resonators can support either standing-or traveling-wave modes. Over the years, the distinction between these two different types of modes has become so prevalent that nowadays it is one of the main characteristics for classifying optical resonators. Here, we show that an intermediate link between these two rather different groups exists. In particular, we introduce a new class of photonic resonators that supports a hybrid optical mode, i.e. at one location along the resonator the electromagnetic fields associated with …


The Human Connection Of Travel: Why Air Travel Will Never Go Away, Maimunah Qureshi Aug 2022

The Human Connection Of Travel: Why Air Travel Will Never Go Away, Maimunah Qureshi

Honors Program Theses and Projects

Advancements in communication and environmental technology may mark the end of aviation as we know it. Numerous people who were forced to remain at home during the pandemic have gotten a taste of a life in which they spend more time with their immediate families and are just as productive at work. Many meetings that individuals used to travel across the nation to attend are now more commonly streamed online for their convenience. Not only that, but the ability to communicate with loved ones who live far away via Facetime and other video-calling technologies has made it possible for us …


Fabrication And Performance Evaluation Of An Evaporative Hollow Micropillar Module For Data Center Cooling Application, Quan Harry Chau Aug 2022

Fabrication And Performance Evaluation Of An Evaporative Hollow Micropillar Module For Data Center Cooling Application, Quan Harry Chau

McKelvey School of Engineering Graduate Student Theses & Dissertations

With the exponential growth of the Internet in the coming decade, data centers will be one of the largest consumers of electricity in many countries. In many data centers, thermal management systems could be just as power-consuming as IT equipment. Chillers in these thermal management systems are one of the highest power components. Microscale evaporation is a promising approach to dissipating high heat fluxes by minimizing thermal resistance between the junction temperature and ambient temperature, hence eliminating the need for chillers. Previous research has shown that droplets elevated by micropillars can limit the vapor diffusion confinement effect, which improves the …


Application Of Fuzzy Logic And Fractal Modeling Approach For Groundwater Potential Mapping In Semi-Arid Akka Basin, Southeast Morocco, Fatima Zahra Echogdali, Said Boutaleb, Rosine Basseu Kpan, Mohammed Ouchchen, Amine Bendarma, Hasna El Ayady, Kamal Abdelrahman, Mohammed S. Fnais, Kochappi Sathyan Sajinkumar, Mohamed Abioui Aug 2022

Application Of Fuzzy Logic And Fractal Modeling Approach For Groundwater Potential Mapping In Semi-Arid Akka Basin, Southeast Morocco, Fatima Zahra Echogdali, Said Boutaleb, Rosine Basseu Kpan, Mohammed Ouchchen, Amine Bendarma, Hasna El Ayady, Kamal Abdelrahman, Mohammed S. Fnais, Kochappi Sathyan Sajinkumar, Mohamed Abioui

Michigan Tech Publications, Part 1

Groundwater potential delineation in the Akka basin, southwest Morocco, has been determined through the combination of geospatial techniques and geological data. The geometric average and expected value are two multi-criteria approaches used to integrate a set of factors–data for which the weights of each factor are assigned using the fuzzy logic function, which transforms values of factors influencing groundwater presence in a range of [0, 1]. The efficiency factors used in this study are the lineament density, node density, drainage density, distance from rivers, distance from lineament, permeability, slope, topographic witness index, plan curvature, and profile curvature. Thereafter, the groundwater …


Study Of Water Desalination: A Persian Gulf City, Grégoire Saury Aug 2022

Study Of Water Desalination: A Persian Gulf City, Grégoire Saury

Student Theses and Dissertations

Water desalination represents an important challenge of tomorrow’s world. Water needs never stop to increase and certain areas of the world relies on ways to have access to this resource. Desalination is a process that offers an alternative access to this vital resource by using seawater as process input. These installations are implementing several purifications units designed to transform seawater into drinkable water. So, they eliminate salt but also any kind of pollution present in the water. Here, the goal will be to design a process able to provide drinkable water for a 200,000 habitants town located in the Persian …


Three-Dimensional Printed Abdominal Imaging Windows For In Vivo Imaging Of Deep-Lying Tissues, Mitchell Kuss, Ayrianne J. Crawford, Olawale A. Alimi, Michael A. Hollingsworth, Bin Duan Aug 2022

Three-Dimensional Printed Abdominal Imaging Windows For In Vivo Imaging Of Deep-Lying Tissues, Mitchell Kuss, Ayrianne J. Crawford, Olawale A. Alimi, Michael A. Hollingsworth, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

The ability to microscopically image diseased or damaged tissue throughout a longitudinal study in living mice would provide more insight into disease progression than having just a couple of time points to study. In vivo disease development and monitoring provides more insight than in vitro studies as well. In this study, we developed permanent 3D-printed, surgically implantable abdominal imaging windows (AIWs) to allow for longitudinal imaging of deep-lying tissues or organs in the abdominal cavity of living mice. They are designed to prevent organ movement while allowing the animal to behave normally throughout longitudinal studies. The AIW also acts as …


Permafrost Landscape History Shapes Fluvial Chemistry, Ecosystem Carbon Balance, And Potential Trajectories Of Future Change, Scott Zolkos, Suzanne E. Tank, Steven V. Kokelj, Robert G. Striegl, Sarah Shakil, Carolina Voigt, Oliver Sonnentag, William L. Quinton, Edward A. G. Schuur, Donatella Zona, Peter M. Lafleur, Ryan C. Sullivan, Masahito Ueyama, David P. Billesbach, David Cook, Elyn R. Humphreys, Philip Marsh Aug 2022

Permafrost Landscape History Shapes Fluvial Chemistry, Ecosystem Carbon Balance, And Potential Trajectories Of Future Change, Scott Zolkos, Suzanne E. Tank, Steven V. Kokelj, Robert G. Striegl, Sarah Shakil, Carolina Voigt, Oliver Sonnentag, William L. Quinton, Edward A. G. Schuur, Donatella Zona, Peter M. Lafleur, Ryan C. Sullivan, Masahito Ueyama, David P. Billesbach, David Cook, Elyn R. Humphreys, Philip Marsh

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Intensifying permafrost thaw alters carbon cycling by mobilizing large amounts of terrestrial substrate into aquatic ecosystems. Yet, few studies have measured aquatic carbon fluxes and constrained drivers of ecosystem carbon balance across heterogeneous Arctic landscapes. Here, we characterized hydrochemical and landscape controls on fluvial carbon cycling, quantified fluvial carbon fluxes, and estimated fluvial contributions to ecosystem carbon balance across 33 watersheds in four ecoregions in the continuous permafrost zone of the western Canadian Arctic: unglaciated uplands, ice-rich moraine, and organic-rich lowlands and till plains. Major ions, stable isotopes, and carbon speciation and fluxes revealed patterns in carbon cycling across ecoregions …


Purification Of Artepillin C (Arc) With Anticancer Activities From Supercritical Co2-Ethanol Extracts Of Brazilian Green Propolis By Using Adsorption Column Chromatography, Lin-Hsiang Chuang, Wen-Chin Chen, Wen Pei, Ming-Hsi Chuang, Todd Hsu, Po-Chao Chuang Aug 2022

Purification Of Artepillin C (Arc) With Anticancer Activities From Supercritical Co2-Ethanol Extracts Of Brazilian Green Propolis By Using Adsorption Column Chromatography, Lin-Hsiang Chuang, Wen-Chin Chen, Wen Pei, Ming-Hsi Chuang, Todd Hsu, Po-Chao Chuang

Journal of Marine Science and Technology–Taiwan

Phenolic compounds with varying phenolic structures are present in both terrestrial and marine organisms. Artepillin C (ARC) is a prenylated phenolic compound produced specifically in Brazilian green propolis. Earlier studies have demonstrated the potential of ARC as a dietary supplement for cancer prevention due to its ability to suppress tumor growth and metastasis. Here we report the development of an effective adsorption chromatography combined with supercritical CO2 extraction for the massive purification of ARC. A mixture of supercritical CO2 and ethanol extract of Brazilian green propolis was passed through a stainless chromatographic column packed with protruding metals at 4,000 psi …


A Stochastic Sailing Speed Optimization And Vessel Deployment Problem In Liner Shipping, Dung-Ying Lin, Pak Weng Leong Aug 2022

A Stochastic Sailing Speed Optimization And Vessel Deployment Problem In Liner Shipping, Dung-Ying Lin, Pak Weng Leong

Journal of Marine Science and Technology–Taiwan

In this research, we consider the stochastic sailing speed optimization and vessel deployment problem and examine the trade-off between sailing speed and the number of vessels required to provide a certain service in international liner shipping. Solving this kind of stochastic program is a challenging task. To address this issue, we construct a mathematical formulation based on Ng (1) and Ng (2) and enhance the linearization techniques from Wang and Meng (3) so that problem instances of an even larger scale can be solved. The proposed formulation has been numerically applied to solve realistic cases, and the empirical results show …


Vehicle Assignment For Chemicals Transportation, Yu-Liang Liu, Juan Huang, Ching-Wu Chu Aug 2022

Vehicle Assignment For Chemicals Transportation, Yu-Liang Liu, Juan Huang, Ching-Wu Chu

Journal of Marine Science and Technology–Taiwan

Vehicle assignment is a significant challenge faced by chemical logistics companies. The chemical industry typically outsources the delivery of chemicals to professional logistics companies to meet customers' complex and demanding needs. In this regard, this research explores the case study of a logistics company that selects its delivery modes and formulates its vehicle assignment plans based on its personnel’s experience rather than any formal system and plans its vehicle routes on the day before the delivery. This study seeks to improve the efficiency and immediacy of logistics companies’ vehicle assignments, understand vehicle route planning, maximize space utilization, and minimize transportation …


A Hybrid Finite Difference Method For Singularly Perturbed Delay Partial Differential Equations With Discontinuous Coefficient And Source, Nitika Sharma, Aditya Kaushik Aug 2022

A Hybrid Finite Difference Method For Singularly Perturbed Delay Partial Differential Equations With Discontinuous Coefficient And Source, Nitika Sharma, Aditya Kaushik

Journal of Marine Science and Technology–Taiwan

The article presents a hybrid finite difference scheme to solve a singularly perturbed parabolic functional differential equation with discontinuous coefficient and source. The simultaneous presence of deviating argument with a discontinuous source and coefficient makes the problem stiff. The solution of the problem exhibits turning point behaviour across discontinuity as tends to zero. The hybrid scheme presented is a composition of a central difference scheme and a midpoint upwind scheme on a specially generated mesh. At the same time, an implicit finite difference method is used to discretize the time variable. Consistency, stability, and convergence of the presented numerical approach …


Simulating And Predicting Offshore Oil Spills By Using Cellular Automata, Lin Liu, Wanwu Li, Yumeng Cui, Guanghui Hu, Hang Li Aug 2022

Simulating And Predicting Offshore Oil Spills By Using Cellular Automata, Lin Liu, Wanwu Li, Yumeng Cui, Guanghui Hu, Hang Li

Journal of Marine Science and Technology–Taiwan

In recent years, offshore oil spill accidents have caused substantial damage to both marine organisms and marine ecology. Accurate simulation and prediction of oil spills could provide a scientific basis for assessing losses due to oil spills and provide support for emergency decisions regarding oil spills. We analyzed the advantages and disadvantages of existing oil spill models and constructed an offshore oil spill model based on cellular automata (CA). By considering both the flow field and wind field, we formulated new CA rules for the diffusion and drift of a pollution zone, and in our model, the cellular state in …


Design And Testing Of A Bearing Less Piezo Jet Micro Heat Sink, Rong-Tsu Wang, Jung-Chang Wang, Sih-Li Chen Aug 2022

Design And Testing Of A Bearing Less Piezo Jet Micro Heat Sink, Rong-Tsu Wang, Jung-Chang Wang, Sih-Li Chen

Journal of Marine Science and Technology–Taiwan

The present study utilized piezoelectric ceramics (PC) as actuators to design five new piezoelectric heatsinks and preliminarily investigated the different design types and their operating conditions, such as the frequency, placement distance, thickness between piezoelectric sheets, piezoelectric sheet size, and noise produced. The results showed that when the micro heatsink bearingless piezo jet was placed too close to the heat source, the high temperature sucked back the surrounding fluids, causing the fluid chamber temperature to rise and the cooling effect to be reduced. Therefore, the heatsink should be placed between 10 and 20 mm from the heat source. With the …


Investigating Features And Output Correlation Coefficient Of Natural Fiber-Reinforced Poly(Lactic Acid) Biocomposites, Andreas Federico, Siti Norasmah Surip, Wan Nor Raihan Wan Jaafar, Jaka Fajar Fatriansyah, Agrin Febrian Pradana Aug 2022

Investigating Features And Output Correlation Coefficient Of Natural Fiber-Reinforced Poly(Lactic Acid) Biocomposites, Andreas Federico, Siti Norasmah Surip, Wan Nor Raihan Wan Jaafar, Jaka Fajar Fatriansyah, Agrin Febrian Pradana

Journal of Materials Exploration and Findings

Polylactic acid (PLA) material has the potential to be applied in various industrial fields, but this material has shortcomings in terms of mechanical properties, especially mechanical strength, due to brittleness nature of PLA. The manufacture of PLA composite material with the addition of natural fibers as a reinforcing phase is one of the methods to increase the impact strength and maintain the biodegradable properties of the material. However, in theory, there are many factors that affect the mechanical properties of composite materials, thus making the mechanical properties of composites more complex than monolithic materials. The mechanical properties of these composite …


Machine Learning Assisted High-Sensitivity And Large-Dynamic-Range Curvature Sensor Based On No-Core Fiber And Hollow-Core Fiber, Chen Zhu, Yiyang Zhuang, Jie Huang Aug 2022

Machine Learning Assisted High-Sensitivity And Large-Dynamic-Range Curvature Sensor Based On No-Core Fiber And Hollow-Core Fiber, Chen Zhu, Yiyang Zhuang, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

Simultaneously Increasing the Sensitivity and Dynamic Range of an Optical Fiber Sensor is Desired and Yet Challenging. in This Article, We Demonstrate an Optical Fiber Curvature Sensor based on a No-Core Fiber (NCF) Cascaded with a Hollow-Core Fiber (HCF), Realizing Simultaneously High Sensitivity and a Large Dynamic Range with the Assistance of Machine Learning Analysis. the Sensor is Fabricated by Simply Fusion Splicing a Section of NCF and HCF to Two Single-Mode Fibers (SMFs), Forming the SMF-NCF-HCF-SMF Hybrid Structure. It is Shown that the Multimode Interference in the NCF Can Increase the Sensitivity of the Device for Curvature Measurements, Compared …


Role Of Ligand Architecture On Collective Cell Invasion, Amrit Bagchi Aug 2022

Role Of Ligand Architecture On Collective Cell Invasion, Amrit Bagchi

McKelvey School of Engineering Graduate Student Theses & Dissertations

Epithelial cell collectives utilize extra-cellular matrix (ECM) fibers to undergo collective migration critical in regeneration, repair and cancer metastasis. However, very little is known about the various factors which determine the ability of cellular collectives to utilize ECM fibers to undergo these critical processes in-vivo. First part of the dissertation focusses on understanding how cell collectives exploit specific properties, like stiffness and fiber length to undergo collective streaming. It is also unclear how cellular forces, cell-cell adhesion, and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of …


Intrinsic Cardiac Effects Of Severe Acute Respiratory Syndrome Coronavirus 2 In Coronavirus Disease 2019, Brittany Danielle Brumback Aug 2022

Intrinsic Cardiac Effects Of Severe Acute Respiratory Syndrome Coronavirus 2 In Coronavirus Disease 2019, Brittany Danielle Brumback

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cardiac arrhythmias, particularly ventricular arrhythmias, can be life-threatening and caused by both congenital genetic mutations and acquired cardiac injury. My thesis work was originally focused on delineating the effects of genetic mutation-driven dysregulation of a protein called Hey2 in Brugada Syndrome, a complex disease characterized by a predisposition to dangerous arrhythmias originating in the right ventricular outflow tract. In response to the pandemic, my thesis work shifted toward understanding the mechanisms of cardiovascular injury in Coronavirus disease 2019 (COVID-19), which is associated with serious cardiovascular complications, including ventricular arrhythmias and sudden cardiac death as well as endothelial dysfunction and coagulopathies. …


Measuring G Protein Activation With Spectrally Resolved Fluorescence Fluctuation Spectroscopy, Daniel Foust Aug 2022

Measuring G Protein Activation With Spectrally Resolved Fluorescence Fluctuation Spectroscopy, Daniel Foust

McKelvey School of Engineering Graduate Student Theses & Dissertations

Fluorescence fluctuation spectroscopy (FFS) is comprised of a set of statistical techniques used to learn information about fluorescence particles by analyzing intensity fluctuations in signals detected from a fluorescence spectrometer or microscope. In biological contexts, FFS is commonly used to quantify the concentrations, molecular brightnesses, and transport properties (e.g. diffusion coefficients) of labeled biomolecules. In particular, the molecular brightness parameter is valuable because it can be used to quantify oligomerization of biomolecules. Therefore, FFS has emerged as an attractive tool for measuring protein-protein interactions in live cells. This dissertation describes the development of image-based, multicolor FFS techniques. Image-based FFS is …


Photochemical Formation Mechanisms And Applications Of Mn Oxide Nanomaterials, Zhenwei Gao Aug 2022

Photochemical Formation Mechanisms And Applications Of Mn Oxide Nanomaterials, Zhenwei Gao

McKelvey School of Engineering Graduate Student Theses & Dissertations

Manganese (Mn) oxides are ubiquitous in aquatic and terrestrial environments, and the rich redox chemistry of manganese is of interest in engineered systems, such as batteries and water oxidation catalysts. Mn oxides have large surface areas and are highly active in adsorption and redox reactions. Our research group recently reported photochemically-assisted abiotic inorganic oxidation of Mn2+(aq) to δ-MnO2 nanosheets in the presence of nitrate and without a microorganism, demonstrating that abiotic Mn oxidation processes are not negligible. My doctoral work focuses on investigating the effects of various aquatic chemistry parameters, including reactive oxygen species (ROS), peroxyl radical (ROO•), reactive halogen …


Nano-Bio Interactions: Implications And Applications, Anushree Ghosh Aug 2022

Nano-Bio Interactions: Implications And Applications, Anushree Ghosh

McKelvey School of Engineering Graduate Student Theses & Dissertations

Rapid expansion of technology development at the nanoscale has underpinned a promising industry. Towards this, there remain significant information gaps which are critical with regard to decision making processes and ultimate industrial sustainability. From an implication point of view, understanding how common biological macromolecules, including glycolipids and/or biopolymers produced by bacteria and fungi, which are ubiquitous in the environment, is fundamental to predicting the behavior of released/produced nanoparticles. Conversely, other bio-based tailored macromolecules, including mussel foot protein (MFP), have significant potential as functional material coatings for advanced applications.This PhD thesis is focused on interfacial processes related to superparamagnetic iron oxide …


Understanding Control Of Metabolite Dynamics And Heterogeneity, Christopher John Hartline Aug 2022

Understanding Control Of Metabolite Dynamics And Heterogeneity, Christopher John Hartline

McKelvey School of Engineering Graduate Student Theses & Dissertations

Microbes live in complex and continually changing environments. Rapid shifts in nutrient availability are a common challenge for microbes, and cause changes in intracellular metabolite levels. Microbial response to dynamic environments requires coordination of multiple levels of cellular machinery including gene expression and metabolite concentrations. This coordination is achieved through metabolic control systems, which sense metabolite concentrations and direct cellular activity in response. Several reoccurring control architectures are found throughout diverse metabolic systems, which suggests underlying evolutionary advantages for using these control systems to coordinate metabolism. One common, yet understudied, control architecture is the positive feedback metabolite uptake loop, which …


Plasmonic Nanomaterials-Based Point-Of-Care Biosensors, Rohit Gupta Aug 2022

Plasmonic Nanomaterials-Based Point-Of-Care Biosensors, Rohit Gupta

McKelvey School of Engineering Graduate Student Theses & Dissertations

Point-of-care (POC) biosensors, although rapid and easy-to-use, are orders magnitude less sensitive than laboratory-based tests. Further they are plagued by poor stability of recognition element thus limiting its widespread applicability in resource-limited settings. Therefore, there is a critical need for realizing stable POC biosensors with sensitivity comparable to gold-standard laboratory-based tests. This challenge constitutes the fundamental basis of this dissertation work– to expand access to quality and accurate biodiagnostic tools. At the heart of these solutions lies plasmonic nanoparticles which exhibit unique optical properties which are attractive for label-free and labelled biosensors.Firstly, we improve the stability and applicability of label-free …


Modeling The Effects Of Mechanical Loading On Hypertrophic Cardiomyopathy Pathogenesis In Human Induced Pluripotent Stem Cell Derived Micro Heart Muscle, Jingxuan Guo Aug 2022

Modeling The Effects Of Mechanical Loading On Hypertrophic Cardiomyopathy Pathogenesis In Human Induced Pluripotent Stem Cell Derived Micro Heart Muscle, Jingxuan Guo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sudden cardiac death in the young is devastating. Advances in genetics have associated mutations in the contractile sarcomere apparatus of cardiomyocytes with hypertrophic cardiomyopathy, the most frequent cause of sudden cardiac death in the young. Currently, it is challenging to predict genotype-phenotype relationships in hypertrophic cardiomyopathy due to its incomplete disease penetrance. For example, different patients from the same family with identical genomic variants develop different symptoms. Non-genetic, environmental factors such as blood pressure are critical in heart function and disease. Therefore, understanding how mechanical factors contribute to phenotypes in diseases like hypertrophic cardiomyopathy is critical for developing effective therapeutics. …