Digital Commons Network^™

Coupled Oscillators: Protein And Acoustics, Angelique N. Mcfarlane

Theses

This work encompassed three different vibrational energy transfer studies of coupled resonators (metal, topological, and microtubule comparison) inspired by the lattices of microtubules from regular and cancerous cells. COMSOL Multiphysics 5.4 was utilized to design the experiment. The simulation starts with an acoustic pressure study to examine the vibrational modes present in coupled cylinders, representing α-, β-tubulin heterodimers. The Metal Study consisted of 3 models (monomer, dimer, and trimer) to choose the correct height (40 mm) and mode (Mode 1) for study. The Topological Study was run to predict and understand how the lattice structure changes over a parametric sweep …

Neonicotinoid Pesticide And Nitrate Mixture Removal And Persistence In Floating Treatment Wetlands, Julia K. Lindgren, Tiffany L. Messer, Daniel N. Miller, Daniel D. Snow, Thomas G. Franti

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Mesocosm and microcosm experiments were conducted to explore the applicability of floating treatment wetlands (FTWs), an ecologically based management technology, to remove neonicotinoid insecticides and nitrate from surface water. The mesocosm experiment evaluated three treatments in triplicate over a 21-d period. Floating treatment wetland mesocosms completely removed nitrate-N over the course of the experiment even when neonicotinoid insecticides were present. At the completion of the experiment, 79.6% of imidacloprid and degradation byproducts and 68.3% of thiamethoxam and degradation byproducts were accounted for in the water column. Approximately 3% of imidacloprid and degradation byproducts and 5.0% of thiamethoxam and degradation byproducts …

Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak

Makara Journal of Technology

Software for interactive musculoskeletal modeling applies diverse scientific and technological concepts to stimulate the movement of musculoskeletal figures. Several tools are available for biomechanical analysis in studying motion and capturing the musculoskeletal representation data to facilitate further evaluation for muscle activation. Musculoskeletal software, such as the OpenSim model, animates, and measures in 3D the structural movement of bones, muscles, joints, ligaments, and such structures in the human body. Users apply graphical interfaces to manipulate the movement science for fast and accurate analysis. OpenSim simulation software features a user-friendly interface to allow the proper clinical application in biomechanics and rehabilitation research. …

Effect Of Alloying Elements On The Compressive Mechanical Properties Of Biomedical Titanium Alloys: A Systematic Review, Syed Faraz Jawed, Chirag Dhirajlal Rabadia, Muhammad Ahmed Khan, Saad Jawaid Khan

Research outputs 2022 to 2026

Due to problems such as the stress-shielding effect, strength-ductility trade-off dilemma, and use of rare-earth, expensive elements with high melting points in Ti alloys, the need for the design of new Ti alloys for biomedical applications has emerged. This article reports the effect of various alloying elements on the compressive mechanical performance of Ti alloys for biomedical applications for the first time as a systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines on this subject. The search strategy in this systematic review used Scopus, Web of Science, and PubMed databases and searched the articles …

Towards Public Vaccination Data Resilience During Natural Disaster Using Blockchain-Based Decentralized Application, Riri Fitri Sari, Mokhammad Rizqi Herdiawan, Muhammad Hamzah, Muhammad Aljundi, Jauzak Hussaini Windiatmaja

Smart City

This paper presents a platform development plan for a public vaccination decentralized data base based on Blockchain technology. Vaccination is a medical practice that allows a human body to produce a specific antibody as a means of developing a preventive measure and reducing the risk of contracting a particular disease. Systematic vaccination data recording is an utmost important system that is required particularly during the Covid-19 pandemic. The recording mechanism should utilize the state-of-the-art information and communication technology (ICT). For faster vaccination data recording, it is common to use digital technology, making the health care process faster thus decreasing time …

Study On Pollution Management And Pollution Emergency Of Offshore Oil Drilling Platform, Jun Shi

World Maritime University Dissertations

No abstract provided.

Effects Of Various Solvents On Adsorption Of Organics For Porous And Nonporous Quartz Co2 Brine Systems: Implications For Co2 Geo-Storage, Muhammad Ali, Nurudeen Yekeen, Mujahid Ali, Mirhasan Hosseini, Nilanjan Pal, Alireza Keshavarz, Stefan Iglauer, Hussein Hoteit

Research outputs 2022 to 2026

The underground geo-storage of carbon dioxide (CO₂) is an essential component of the carbon capture and sequestration value chain. The success of CO₂ containment depends on the wetting state of the rock, which controls the mechanism of fluid flow and distribution. The presence of organic acids in the storage formation introduces a considerable effect on the wettability of the rock / CO₂ / brine system under various temperature and pressure conditions. Despite the previous studies on this topic, the impact of the substrate pores, the rock surface roughness, and the solvents used to prepare the organic …

Research On Countermeasures To Strengthen Domestic Traffic Safety Based On Risk Control, Hui Lin

World Maritime University Dissertations

No abstract provided.

Scaling Cellular Agriculture Production With Photolithography: A Study On Curing And Degradation, Alexis Garrett

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

To meet the requirements for full production in cellular agriculture, a multi-disciplinary approach is required. New questions and understandings between different concepts, such as texture and cooking, need to be identified and how they correlate with cellular behavior and taste. This work focuses on understanding and developing photolithographic systems for scalable cellular agriculture. There were two specific research directions: 1) a traditional photolithography printing system was improved upon for mass manufacturing purposes and 2) mechanical analysis and degradation of key potential photolithographic biomaterials were tested for a food product. A novel digital rotational ultraviolet manufacturing (DRUM) process was developed, and …

Biofilms: Formation, Research Models, Potential Targets, And Methods For Prevention And Treatment, Yajuan Su, Jaime T. Yrastorza, Mitchell Matis, Jenna Cusick, Siwei Zhao, Guangshun Wang, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Due to the continuous rise in biofilm-related infections, biofilms seriously threaten human health. The formation of biofilms makes conventional antibiotics ineffective and dampens immune clearance. Therefore, it is important to understand the mechanisms of biofilm formation and develop novel strategies to treat biofilms more effectively. This review article begins with an introduction to biofilm formation in various clinical scenarios and their corresponding therapy. Established biofilm models used in research are then summarized. The potential targets which may assist in the development of new strategies for combating biofilms are further discussed. The novel technologies developed recently for the prevention and treatment …

Design Of Novel Metalloenzymes And Investigation Of Protein-Metal Interactions, Alona Kulesha

Dissertations - ALL

Metalloproteins are the proteins that utilize metals or metal complexes as cofactors and exhibit a wide range of functions from oxygen transport and regulation of transcription to hydroxylation of alkanes and water splitting, even though they employ a limited set of metals and metal-binding ligands. The investigation of metalloprotein amino acid sequence, structure and function relationships can uncover the principles behind natural metalloprotein design and opens the possibility of their implication as scaffolds for the design of novel catalysts and biomaterials. Protein engineering is a set of techniques that allows to install new functionalities into existing proteins or to design …

Advanced Lithium Metal Batteries: Functional Electrolyte Additive And Lithium Metal/Solid-State Electrolyte Interface Engineering, Abiral Baniya

Dissertations - ALL

Majority of the energy in current world is produced and consumed by burning non-renewable fossil fuel sources such as coal, oil, and natural gas, etc. It is taking a toll on our planet earth due to high rates of carbon and greenhouse emissions. This calls for an urgent need of energy transition from conventional fossil fuel to renewable and sustainable energy sources such as solar, wind, geothermal, etc. However, harnessing energy from such renewables are constrained by their intermittency and non-dispatchability, requiring some sort of efficient energy storage systems that can provide continuous energy supply. Batteries in general are considered …

Leveraging Isocyanate Chemistry For Low Cost And Highly Functional Hydrogels, Henry Beaman

Dissertations - ALL

The development of novel biomaterials is an important step in providing higher quality products for wound healing, drug delivery, and tissue engineering. Progress is consistently being made in the development of new polymers, yet new polymer systems are often expensive and/or involve complex multistep synthesis methods. These limitations could hinder the translation and scalability of functionalized materials. To address the issues of complex synthesis and high cost, we have devised strategies for polymeric modification using isocyanate chemistry. Isocyanates are used in the manufacturing of polyurethanes. Isocyanates are highly reactive with common functional groups, such as amines, hydroxyls, and carboxylic acids. …

Targeted Mesenchymal Stem Cell Differentiation From Induced Pluripotent Stem Cells For Therapeutic Application, Tackla Winston

Dissertations - ALL

Over the past decade, mesenchymal stem cells have increasingly gained interest as a cell source for the treatment of a variety of diseases. This is because they play several roles in tissue homeostasis and regeneration, such as altering the immune response to limit inflammation, aiding tissue repair through the release of various proteins, cytokines and growth factors, or differentiating into functional cells in specific tissues. The interest in MSCs for biomanufacturing applications has resulted in the development of various protocols to differentiate them from pluripotent sources. These protocols, however, fail to account for the differences that exist between MSCs from …

Exploring The Roles Of Organic Matter Source And Transformation For Photochemical Characterization Of New York Lake Waters, Joseph Wasswa

Dissertations - ALL

Dissolved organic matter (DOM) is a critical component of aquatic systems that serves many purposes. Among them is the production of reactive intermediates (RIs) when irradiated with sunlight. Examples of RIs produced include the excited triplet states of dissolved organic matter (3DOM*), singlet oxygen (1O2), and hydroxyl radicals (•OH), all of which contribute to the degradation or inactivation of chemical or microbiological contaminants. It is therefore critical to understand how the sources and transformations of DOM may affect the production of RIs in sunlit aquatic systems.

The Adirondack Mountain region of New York, a historical hotspot for atmospheric sulfur and …

Analysis And Visualization Of Molecular Docking 2hi4 Protein, Innas Widiasti

Indonesian Journal of Medical Chemistry and Bioinformatics

The crystal structure of the human microsomal complex P450 1A2 with alpha-naphthoflavone, a cytochrome P450 (CYP) enzyme is particularly important, as it is abundant in the human liver and alters a more diverse xenobiotic array than any other group of metabolic enzymes. CYP1A2 is abundantly found in the liver and involved in the metabolism of about 10% of clinically used drugs metabolized by CYP enzymes. The current drug discovery and development mostly uses high-throughput screening (HTS). However, this regular method is time-consuming and costly. To address the issue, an advanced drug discovery and development method namely chemical compound database screening …

Engineering Temporal And Spatial Complexity In Biomaterial Scaffolds For Cardiac Disease Modeling And Mechanobiology, Chenyan Wang

Dissertations - ALL

Temporal and spatial mechanical cues play an important role in heart development, function, and disease manifestation. A deeper understanding of cardiac mechanobiology is especially important for fundamental biology and clinical diagnosis or heart disease treatment. Currently, human induced pluripotent stem cells (hiPSCs) are widely used to build human cell or tissue models, but culturing them in a petri dish fail to recapitulate the mechanical complexity in the native heart. To create a mechanical environment with better pathophysiological relevance, biomaterial scaffolds are usually employed to mimic the mechanical cues originated from extracellular matrix (ECM) remodeling. The goal of this dissertation is …

Girls In Stem! Elementary Afterschool Six-Week Curriculum, Jess Li, Samavi Rafique

Honors Program: Expanded Learning Clubs

No abstract provided.

Speeding Up The Quantification Of Contrast Sensitivity Functions Using Multidimensional Bayesian Active Learning, Shohaib Shaffiey

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

Back To The Future The Spatial Dimension Of Water Management, Kees Lokman

IntAR Interventions Adaptive Reuse

No abstract provided.

Identification Of Lithocholic Acid As A Molecular Glass Host For Room-Temperature Phosphorescent Materials, John J. Flynn, Zachary M. Marsh, Douglas M. Krein, Steven M. Wolf, Joy E. Haley, Erick S. Vasquez, Thomas M. Cooper, Nicholas P. Godman, Tod A. Grusenmeyer

Chemical and Materials Engineering Faculty Publications

Lithocholic acid was identified as a molecular glass host material for room temperature phosphorescent (RTP) chromophores. Differential scanning calorimetry (DSC) was performed on a series of structurally similar, biologically sourced molecules, including lithocholic acid, β-estradiol, cholesterol, and β-sitosterol, in an effort to identify new amorphous molecular glasses independent of plasticizing additives. DSC analysis revealed lithocholic acid and β-estradiol form stable molecular glasses post thermal processing unlike neat cholesterol and β-sitosterol. The ability of lithocholic acid and β-estradiol to stabilize high wt. % loadings of d10-pyrene and a mixture of d10-pyrene and an iridium chromophore, bis(2,4-difluorophenylpyridinato)-tetrakis(1-pyrazolyl)borate iridium(III) (FIr6), was also investigated. …

Between Memory And Invention An Interview With Nietq Sobejano Arquitectos, Luis Sacristán Murga

IntAR Interventions Adaptive Reuse

No abstract provided.

Going Dutch Duplication, Authencity And Reprogrammed Experience, Iris Mach

IntAR Interventions Adaptive Reuse

No abstract provided.

Million Donkey Hotel And Other Memories Of Stone, Michela Bassanelli

IntAR Interventions Adaptive Reuse

No abstract provided.

A Future Of Pilgrimage, Andy Lockyer

IntAR Interventions Adaptive Reuse

No abstract provided.

Alternate Hospitality A New Frontier, Tiziano Aglieri Rinella

IntAR Interventions Adaptive Reuse

No abstract provided.

Bikini Berlin Becoming An Icon Of Post-War Reconstruction, Dionys Ottl

IntAR Interventions Adaptive Reuse

No abstract provided.

More Of Something Else Conjecture One-Thirty (Tu), Jeffry Burchard

IntAR Interventions Adaptive Reuse

No abstract provided.

Postindustrial Spectacle Reconnecting Image And Function, Patrick Ruggiero, Jr.

IntAR Interventions Adaptive Reuse

No abstract provided.

Cathedrals Of Consumerism Experiencing Corporate Interiors And Brands, Sylvia Leydecker

IntAR Interventions Adaptive Reuse

No abstract provided.