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Full-Text Articles in Entire DC Network
Elli’S Liquid Flow In A Wavy Channel With Slip Effect, Wall Properties, And Heat Transfer, P. Devaki, Yatin Sood
Elli’S Liquid Flow In A Wavy Channel With Slip Effect, Wall Properties, And Heat Transfer, P. Devaki, Yatin Sood
Mansoura Engineering Journal
The dual behavior of Elli’s fluid motivated us to work on it. The fluid behaves as both Newtonian/ non-Newtonian based on the low and high shear rates, respectively. The paper focused on the flow of Ellis fluid in a peristaltic channel with wall properties and heat transfer. The channel is symmetric in nature, and slip conditions are considered near the elastic walls. The governing equations of the flow are solved analytically using suitable boundary conditions, which yield velocity and temperature functions. The novelty of the paper is to analyze the nature of Newtonian/non-Newtonian fluids under the same conditions so that …
A. Vs. I In Ai: Is There A Threshold To "Engineered" Intelligence?, Joshit Mohanty
A. Vs. I In Ai: Is There A Threshold To "Engineered" Intelligence?, Joshit Mohanty
Engineering Management & Systems Engineering Faculty Publications
Despite artificial intelligence reshaping the world, its development generates uncertainties regarding future capabilities. AI simultaneously exists as an artifact of engineering design and as autonomous intelligence, creating an observer-participant feedback loop. This paper proposes that embodied AI faces a bandwidth-limited intelligence threshold T_h that it arises from B = min(C_sens,C_Act). However, Shannon capacity measures bits while intelligence operates on concepts, necessitating a dual-channel model separating physical bandwidth B_io from representational capacity B_rep. Intelligence emerges as multi-dimensional rather than scalar, with components exhibiting different bandwidth dependencies. Surpassing T_h requires either new sensing methods expanding B, enhanced representational frameworks, or reconceptualization within …
The Effects Of Low-Frequency, Low-Intensity Ultrasound On Gene Expression In Macrophage-Endothelial Cell Co-Culture, Evelyn Hergenhan
The Effects Of Low-Frequency, Low-Intensity Ultrasound On Gene Expression In Macrophage-Endothelial Cell Co-Culture, Evelyn Hergenhan
Honors Theses
Introduction
Low-frequency, low-intensity ultrasound (LFLI US) has been shown to be a promising treatment for noninvasive accelerated chronic wound healing. However, the biological mechanisms of this ultrasound-assisted healing are not yet understood, limiting clinical adoption. The objective of this study is to characterize the effects of LFLI US on gene expression in a simulated chronic wound environment to gain a better understanding of the biological mechanisms underlying this therapeutic.
Methods
A simulated chronic wound environment consisting of endothelial cells and inflammatory M1 macrophages co-cultured in 3D was subject to LFLI US at 50, 100, or 150 mW/cm2 Spatial-Peak, Temporal-Peak …
Part Ii: Industrial Information Integration Review 2020-2025, Jinzhi Li
Part Ii: Industrial Information Integration Review 2020-2025, Jinzhi Li
Information Technology & Decision Sciences Faculty Publications
Industrial Information Integration Engineering (IIIE) has become increasingly essential for improving operational efficiency and harmonizing heterogeneous industrial systems through advanced digital integration approaches. Fueled by rapid advancements in Industry 4.0 technologies—including digital twins, artificial intelligence, immersive interfaces, and IoT infrastructures—IIIE is substantially transforming traditional enterprise architecture and integration frameworks. This systematic review synthesizes recent developments and emerging trends, with particular attention to the accelerating adoption of digital twins and the deepening convergence between operational technologies (OT) and information technologies (IT) across multiple sectors. While notable progress has been made, significant challenges persist, especially in developing resilient integration architectures and fully …
Captive Model Test For Hydrodynamic Derivatives Of Ship Maneuvering In Regular Head Waves, Pin-Yuan Huang, Zih-Yao Lin, Tsung-Yueh Lin, Fu-En Lee, Yan-Wei Lai
Captive Model Test For Hydrodynamic Derivatives Of Ship Maneuvering In Regular Head Waves, Pin-Yuan Huang, Zih-Yao Lin, Tsung-Yueh Lin, Fu-En Lee, Yan-Wei Lai
Journal of Marine Science and Technology–Taiwan
The motion of ship in wave can be discussed in seakeeping and maneuvering. In model tests, the former is found by the motion response of waves while the latter requires captive model test to acquire hydrodynamic derivatives. The hydrodynamic derivatives in waves are discovered to be different from those in calm water. To understand better the behavior of maneuverability in waves, maneuvering tests in a wide range of waves are performed in this study. This study presents an experimental investigation into the maneuvering behavior of a container ship in regular waves, covering a wide range of wavelengths from half to …
Cross-Linking Peg Microgels With Mesoporous Organosilica Nanoparticles To Engineer Microporous Annealed Particle Scaffold Properties, Jonathan M. Zuidema, Alessandro Ajo, Marco Carofiglio, Luisa De Cola
Cross-Linking Peg Microgels With Mesoporous Organosilica Nanoparticles To Engineer Microporous Annealed Particle Scaffold Properties, Jonathan M. Zuidema, Alessandro Ajo, Marco Carofiglio, Luisa De Cola
Mechanical Engineering Faculty Publications
Microporous annealed particle (MAP) scaffolds composed of cross-linked microgels are emerging as important biomaterials due to their modular design, high porosity, and large surface area, which allow for highly tailored properties, cellular infiltration, nutrient and waste exchange, and improved drug release characteristics. To further expand on these technologies and enhance their modular design, thiolated mesoporous organosilica nanoparticles (ssMSN-SH), which degrade in response to glutathione, were first cross-linked inside of 4-arm poly(ethylene glycol) maleimide microgels. The microgel size, rheological properties, and payload release characteristics were determined. Hierarchical MAP scaffolds were then created by cross-linking 4-arm poly(ethylene glycol) maleimide microgels with ssMSN-SH. …
Ai For Life Sciences: From Geometric Protein Modeling To Multimodal Drug Design, Feng Jiang
Ai For Life Sciences: From Geometric Protein Modeling To Multimodal Drug Design, Feng Jiang
Computer Science and Engineering Dissertations
Predicting biomolecular interactions, from immune recognition to drug–target binding, is a central problem in the life sciences and computational drug discovery. Deep learning has advanced this area, yet three challenges persist: the topology of large, highly imbalanced interaction networks; structural noise in computationally predicted protein models; and the integration of multimodal information such as functional text and taxonomic annotations. This dissertation develops a coherent set of models spanning immune complex prediction and small-molecule drug design: graph learning that addresses network topology and severe class imbalance; a noise-tolerant method that fuses predicted structures with evolutionary sequence features; and multimodal representation learning …
Stentrx, Emma Barna, Minuthi Cooray, Bruce Newlands, Joseph A. Sabetta
Stentrx, Emma Barna, Minuthi Cooray, Bruce Newlands, Joseph A. Sabetta
Williams Honors College, Honors Research Projects
This project aims to develop a biodegradable, drug-eluting biliary stent for the treatment of biliary cancers. Current metal stents that restore bile flow bit are non-degradable, prone to migration, and unable to deliver drugs locally. The proposed stent will be biocompatible, biodegradable, and capable of controlled drug release to both maintain bile flow and treat tumors. The end goal is to produce a functional prototype that can be deployed via a minimally invasive catheter and maintain bile duct patency for at least three months. The project is expected to be involved in the NEOMED Bench-to-Bedside competition and provisionally patented.
Moisture Performance Of Coated Cross-Laminated Timber Under Coastal Conditions In Vertical And Horizontal Orientations With And Without Weather And Vapor Resistive Barriers, Mia Raley
Engineering Theses
Rhode Island is experiencing sea level rise, and more flooding and erosion during storm events due to climate change. The Rhode Island construction industry wants to adopt mass timber, but have concerns with the changing coastal environment on cross-laminated timber (CLT) wall and slab panels. This research aims to understand how coastal conditions affect CLT under different protection conditions, panel orientations, and structure type, by collecting moisture and temperature data on two structures, one commercially-fabricated and one laboratory-fabricated, located on Shell Path from early-July to early-April. Results found that all layers of horizontally-oriented panels benefitted from an additional protective weather-resistant-barrier …
Calcium Based Carbon Negative Fillers And Additives: Effects On Hydration And Performance Of Low-Carbon Cement Systems, Smita Bhowmick Shithi
Calcium Based Carbon Negative Fillers And Additives: Effects On Hydration And Performance Of Low-Carbon Cement Systems, Smita Bhowmick Shithi
Masters Theses
Cement production is a major source of global CO₂ emissions creating an urgent need for carbon-negative fillers and functional additives that lower clinker use while maintaining cement performance. This thesis investigates the effects of organic mineral salts as fillers and additives on cement hydration, fresh properties, compressive strength and pore structure. In the first study, ordinary Portland cement (OPC) was partially replaced with calcium carbonate or calcium oxalate to enable a direct comparison under controlled particle size distribution (PSD). Rheology, flowability, hydration kinetics, phase evolution, mechanical performance and water absorption were evaluated. Calcium carbonate promoted early hydration through nucleation and …
A Comprehensive Statistical And Regional Analysis Of Lng-Powered Marine Vessels On Ghg Mitigation Strategies Considering Existing Bunkering Stations And Gwp Values, Canberk Hazar, Onur Yuksel, Murat Bayraktar
A Comprehensive Statistical And Regional Analysis Of Lng-Powered Marine Vessels On Ghg Mitigation Strategies Considering Existing Bunkering Stations And Gwp Values, Canberk Hazar, Onur Yuksel, Murat Bayraktar
Journal of Marine Science and Technology–Taiwan
This study aims to quantify and analyse emissions from marine vessels that can operate on liquefied natural gas (LNG) but continue to use conventional fuels, largely due to the limited availability of LNG bunkering stations (BSs) over long distances. Four regions have been identified as having high concentrations of LNG-fueled vessels but limited access to operational BSs: the West Coast of the United States of America (USA), South Africa–Good Hope–Madagascar, Northwest Africa, and Brazil. This selection is based on the geographical distribution of these ships and the existing infrastructure. Hourly greenhouse gas (GHG) emissions have been calculated by considering the …
Aster Remote Sensing Satellite Imagery For Regional Mineral Mapping In The Mcmurdo Dry Valleys, South Victoria Land, Antarctica, Khurram Riaz, Amin Beiranvand Pour, Jabar Habashi, Aidy M. Muslim, Iman Masoumi, Ali Moradi Afrapoli, Mazlan Hashim, Kamyar Mehranzamir, Farshid Sattari
Aster Remote Sensing Satellite Imagery For Regional Mineral Mapping In The Mcmurdo Dry Valleys, South Victoria Land, Antarctica, Khurram Riaz, Amin Beiranvand Pour, Jabar Habashi, Aidy M. Muslim, Iman Masoumi, Ali Moradi Afrapoli, Mazlan Hashim, Kamyar Mehranzamir, Farshid Sattari
Mining Engineering Faculty Publications
The McMurdo Dry Valleys (DVs) of South Victoria Land, Antarctica, constitute the largest ice-free region on the continent and one of Earth’s most Mars-analog environments. Their hyper-arid polar desert conditions offer a unique setting for investigating surface weathering and mineralogical processes under extreme climates. This study presents the first regional-scale mapping of alteration and crystalline weathering minerals across the McMurdo DVs. It uses Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) multispectral data; visible and near-infrared (VNIR) and shortwave infrared (SWIR) bands were analyzed through a Spectral Hourglass Workflow, endmember extraction, and spectral unmixing with Matched Filtering (MF) and Constrained …
Characterization Of Tomographic Piv System For Single-Phase Immersion Cooling Applications, Joel Joshua Oommen
Characterization Of Tomographic Piv System For Single-Phase Immersion Cooling Applications, Joel Joshua Oommen
Mechanical and Aerospace Engineering Theses
As the rapid expansion of Artificial Intelligence (AI) infrastructure and High-Performance Computing (HPC) pushes power requirements to new heights, traditional air-cooling methods have become inadequate for modern server demands. Consequently, single-phase immersion cooling (SPIC) has emerged as one of the effective and sustainable alternatives, utilizing dielectric fluids to remove heat through direct contact with electronic components. Despite numerous thermal and reliability studies, the complex three-dimensional movement of buoyant thermal plumes around intricate component shapes are not yet fully understood in confined spaces.
This thesis provides a detailed characterization of Tomo-PIV and a component level experimental study of flow patterns in …
Unveiling Microplastic Removal And Characteristics In Wastewater From Two Municipal Wastewater Treatment Facilities In Indonesia, Nurul Setiadewi, Prayatni Soewondo, Cynthia Henny
Unveiling Microplastic Removal And Characteristics In Wastewater From Two Municipal Wastewater Treatment Facilities In Indonesia, Nurul Setiadewi, Prayatni Soewondo, Cynthia Henny
Applied Environmental Research
Wastewater treatment plants (WWTPs) are considered an entrance pathways for microplastic (MP) pollution in aquatic environments. This study reveals the removal and characteristics of MPs in wastewater from two municipal WWTPs in Indonesia. The influent contained 17.1 ± 5.65 particles L-1 (WWTP A) and 15.45 ± 4.31 particles L-1 (WWTP B), whereas the effluent contained 1.41 ± 0.01 and 1.5 ± 0.16 particles L-1. The removal efficiency was 91.75% for WWTP A and 90.32% for WWTP B, with no statistically significant difference (p > 0.05). WWTP A employed advanced treatment units, whereas WWTP B used a conventional pond-based system. MPs were …
Anaerobic Digestion Of Variable, Heterogeneous Organic Wastes Under Changing Operational Conditions And Bioaugmentation: Impacts On Process Performance And Microbiome Dynamics, Victoria Holliday
Theses and Dissertations--Biosystems and Agricultural Engineering
Expanding the adoption of anaerobic digestion (AD) is limited by system instabilities caused by feedstock composition and variability. Understanding how changes in feedstock and operational parameters influence microbiome dynamics is essential for developing biology-driven strategies to improve digester stability.
Two semi-continuous reactors, an experimental and a control, operated over 39 weeks across five phases with varying feedstocks and organic loading rates. Substrate-specific enrichment cultures were developed for bioaugmentation and implemented in select phases to assess its impact. Both reactors exhibited similar performance, transitioning through periods of stability, stress, and recovery in response to operational changes. Corresponding shifts in dominant taxa …
The Lie Group Basis Of Neuronal Membrane Architecture: Why The Hodgkin–Huxley Equations Take Their Form, Robert Melendy, Daniel Blue
The Lie Group Basis Of Neuronal Membrane Architecture: Why The Hodgkin–Huxley Equations Take Their Form, Robert Melendy, Daniel Blue
Faculty Publications - Department of Electrical Engineering and Computer Science
The Hodgkin–Huxley equations have successfully described neuronal excitability for over seventy years, yet their mathematical structure remains empirically justified rather than theoretically explained. Why are gating variables bounded between 0 and 1? Why does sodium conductance depend on m3h rather than other combinations? Why does potassium depend on n4? Why do all rate functions contain exponential voltage dependencies? Why are the kinetics first-order? We demonstrate that these structural features arise naturally from three fundamental physical symmetries governing ion channel dynamics: the compactness of conformational state space, the scaling invariance of membrane conductance, and temporal translation invariance. …
Viscoelastic Behavior Of Magnetically Filled Pdms Elastomers: Influence Of Filler Loading And Particle Type, Madison Procyk
Viscoelastic Behavior Of Magnetically Filled Pdms Elastomers: Influence Of Filler Loading And Particle Type, Madison Procyk
College of Graduate Studies: Theses & Dissertations
Magnetorheological elastomers (MREs) offer a promising pathway for soft, magnetically actuated drug‑delivery systems, yet material‑selection guidelines remain unclear due to limited comparative data across particle chemistries, size scales, and concentrations. This study systematically evaluates how magnetic filler type (carbonyl iron and magnetite) and particle size (micro vs. nano), at two weight percentages – 40 wt% and 50 wt% – in Sylgard 184 PDMS influence the viscoelastic behavior of MREs intended for compliant biomedical actuation. Eight particle formulations were prepared through sieving, controlled mixing, vacuum degassing, and isotropic curing, producing nineteen total specimens (16 with filler particles and 3 without). Dynamic …
C2p-M: Critical Connection Protection In Multiplex Graphs, Conggai Li, Wei Ni, Ming Ding, Youyang Qu, Jianjun Chen, Wenjie Zhang, Thierry Rakotoarivelo
C2p-M: Critical Connection Protection In Multiplex Graphs, Conggai Li, Wei Ni, Ming Ding, Youyang Qu, Jianjun Chen, Wenjie Zhang, Thierry Rakotoarivelo
Research outputs 2022 to 2026
Multiplex graphs represent diverse real-world interactions among entities, where multiple relationship types coexist within the same set of entities. These graphs introduce privacy risks, as data collectors can exploit cross-layer dependencies to infer hidden and sensitive connections. In this work, we propose a C2P-M framework that identifies and protects critical connections while preserving the structural information in multiplex graphs. Unlike conventional methods for single-layer graphs that perturb all edges uniformly, C2P-M selectively protects critical connections, maintaining the analytical usability of the graph. To achieve this, we introduce the multiplex p-cohesion model, which incorporates new score functions that account for both …
Synergistic Removal Of Microplastic Fibres: Integrating Chitosan Coagulation In Hybrid Water Pre-Treatment Systems, Jayasuriya Arachchilage Nimesha Thathsarani
Synergistic Removal Of Microplastic Fibres: Integrating Chitosan Coagulation In Hybrid Water Pre-Treatment Systems, Jayasuriya Arachchilage Nimesha Thathsarani
Theses: Doctorates and Masters
Microplastic fibres (MPFs) are the most prevalent form of microplastics detected in the influents of water and wastewater treatment plants. Owing to their elongated shape and low density, MPFs frequently evade removal even during tertiary processes such as membrane filtration. Enhancing pretreatment, particularly through cost-effective coagulation-flocculation can reduce the treatment burden on downstream systems. However, conventional inorganic coagulants often necessitate high dosages and can leave residual ions, posing environmental concerns.
As a sustainable alternative, the use of environmentally friendly coagulants such as Chitosan has gained attention for MPF removal. While Chitosan exhibits favourable qualities, its practical application is hindered by …
Implementation And Clinical Utility Of Ultra-Low-Field Portable Magnetic Resonance Imaging For Postprocedural Neurological Evaluation In Ambulatory Neurosurgery: Illustrative Cases, Devan Patel, Vinay Jaikumar, Taysia P. T. Morioka, Laz Rifkin, Kenneth S. Jacoby, Jaims Lim, Anais Andrade, Aimee C. Degaetano, Pui Man Rosalind Lai, Elad I. Levy
Implementation And Clinical Utility Of Ultra-Low-Field Portable Magnetic Resonance Imaging For Postprocedural Neurological Evaluation In Ambulatory Neurosurgery: Illustrative Cases, Devan Patel, Vinay Jaikumar, Taysia P. T. Morioka, Laz Rifkin, Kenneth S. Jacoby, Jaims Lim, Anais Andrade, Aimee C. Degaetano, Pui Man Rosalind Lai, Elad I. Levy
EVMS School of Health Professions Faculty Publications
BACKGROUND
Elective endovascular neurosurgical procedures are increasingly performed in ambulatory neurosurgery centers, enabled by advances in catheter technology, safety of conscious sedation, and refined patient selection. Although complication rates are low, rapid evaluation of postprocedural neurological deficits remains critical. Conventional MRI is often impractical in outpatient or procedural settings, whereas ultra-low-field portable MRI (ULF-pMRI) systems (such as Swoop) allow bedside imaging with favorable diagnostic performance.
OBSERVATIONS
Two women in their 60s developed acute neurological deficits at an ambulatory neurosurgery center (ANSC) after diagnostic cerebral angiography in one case and elective internal carotid artery flow diversion in the other. In both …
Large Language Models For Neurology: A Mini Review, Donald C. Wunsch, Daniel B. Hier
Large Language Models For Neurology: A Mini Review, Donald C. Wunsch, Daniel B. Hier
Electrical and Computer Engineering Faculty Research & Creative Works
Large language models have the potential to transform neurology by augmenting diagnostic reasoning, streamlining documentation, and improving workflow efficiency. This Mini Review surveys emerging applications of large language models in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and epilepsy, with emphasis on ambient documentation, multimodal data integration, and clinical decision support. Key barriers to adoption include bias, privacy, reliability, and regulatory alignment. Looking ahead, neurology-focused language models may develop greater fluency in biomedical ontologies and FHIR standards, improving data interoperability and supporting more seamless collaboration between clinicians and AI systems. Two future developments have the potential to be particularly impactful: (1) …
Performance Analysis And Optimization Of Fructose Memristor-Based Neuromorphic Systems, Harshvardhan Uppaluru, Shakil Mahmud Jiban, Shah Zayed Riam, Feng Zhao, Jinhui Wang
Performance Analysis And Optimization Of Fructose Memristor-Based Neuromorphic Systems, Harshvardhan Uppaluru, Shakil Mahmud Jiban, Shah Zayed Riam, Feng Zhao, Jinhui Wang
Electrical and Computer Engineering Faculty Research & Creative Works
Natural organic memristors have demonstrated promising synaptic behavior, positioning them as strong candidates for synaptic devices in neuromorphic systems. This paper presents the fabrication and evaluation of a neuromorphic system based on natural organic 16-level and 32-level fructose memristors. First, the manufacturing process of fructose memristors is described in detail. Second, the nonlinear property associated with fructose memristors is investigated, and an optimization method is applied to address the nonlinear effects. The performance of the fructose memristor-based neuromorphic system on MNIST with a multi-layer perceptron and on CIFAR-10 with VGG-8 is evaluated and reported under various conditions -with/without nonlinearity optimization …
New Metrics For Disambiguating Feature Overlap And Catastrophic Forgetting In Incremental Learning Contexts, Niklas M. Melton, Leonardo Enzo Brito Da Silva, Donald C. Wunsch
New Metrics For Disambiguating Feature Overlap And Catastrophic Forgetting In Incremental Learning Contexts, Niklas M. Melton, Leonardo Enzo Brito Da Silva, Donald C. Wunsch
Electrical and Computer Engineering Faculty Research & Creative Works
Catastrophic forgetting remains a central challenge in lifelong learning, where newly acquired knowledge interferes with previously learned tasks, degrading performance over time. Mitigation strategies such as rehearsal and regularization have been proposed, but both introduce limitations, either by retaining old data or by constraining model updates in ways that may impair learning. Complicating matters, recent findings show that feature-space overlap between tasks can produce similar performance drops even in models that memorize data, making it difficult to distinguish true forgetting from representational interference. Current accuracy-based metrics fail to disentangle these effects, undermining diagnostic clarity. In this work, we introduce the …
Honey-Cnt Memristive Artificial Synaptic Device For Sustainable Neuromorphic Computing System, Md Mehedi Hasan Tanim, Zoe Templin, Harshvardhan Uppaluru, Jinhui Wang, Kuan Yew Cheong, Feng Zhao
Honey-Cnt Memristive Artificial Synaptic Device For Sustainable Neuromorphic Computing System, Md Mehedi Hasan Tanim, Zoe Templin, Harshvardhan Uppaluru, Jinhui Wang, Kuan Yew Cheong, Feng Zhao
Electrical and Computer Engineering Faculty Research & Creative Works
Brain-inspired neuromorphic computing systems require hardware components analogous to biological neurons and synapses. Honey based natural organic memristor has demonstrated promising nonvolatile memristive behaviors, with the advantages of sustainability, environmentally friendliness, and low-cost manufacturing. In this study, carbon nanotubes (CNTs) are added in honey to fabricate honey-CNT memristive artificial synaptic devices. Honey-CNT film is characterized by micro-Raman spectroscopy and the distribution of CNT bundles embedded in the honey-CNT composite layer by cross-sectional scanning electron microscopy for the first time. Critical synaptic functions of the honey-CNT memristor, including spike-rate-dependent plasticity, spike voltage dependent plasticity, learn-forget-relearn, and supralinear spatial summation are revealed, …
Enhancing Explainable Ai For Medical Imaging: Improved Lime Interpretation With Influence Mapping, Abiha Tahsin Chowdhury, Dhanush Bavisetti, Daniel B. Hier, Rahul Dubey, Tayo Obafemi-Ajayi
Enhancing Explainable Ai For Medical Imaging: Improved Lime Interpretation With Influence Mapping, Abiha Tahsin Chowdhury, Dhanush Bavisetti, Daniel B. Hier, Rahul Dubey, Tayo Obafemi-Ajayi
Electrical and Computer Engineering Faculty Research & Creative Works
The integration of artificial intelligence (AI) into medical imaging is progressing rapidly. It is essential for these AI tools to be transparent, interpretable, and explainable to gain the trust of clinicians and regulators. Current state-of-the-art explainable AI (XAI) techniques in imaging includes Local Interpretable Model-Agnostic Explanations (LIME), Shapley Additive Explanations (SHAP), and Gradient-weighted Class Activation Mapping (Grad-CAM). Recent studies have shown that LIME often suffers from inconsistency and unreliability which limits their utility in sensitive fields like medical imaging. This paper proposes Influence Map based Explanation (IME), an enhanced variant of the original LIME framework, that aggregates multiple runs to …
Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson
Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson
Department of Medicine Faculty Publications
Micro- and nanoplastics (MNPs) are pervasive in food-contact environments and the human diet, positioning the gastrointestinal (GI) tract as the primary portal of entry and a plausible site of early biological effects. Human exposure is supported by detection of microplastics in stool and colon tissue, and emerging clinical studies report associations between fecal microplastic burden and GI disease states, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). Preclinical studies provide mechanistic plausibility, reporting that ingested MNPs can modulate microbial ecology, alter mucus membrane integrity, increase intestinal permeability through changes in cellular tight junction biology, and induce inflammatory gene expression. …
Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey
Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey
Bioelectrics Publications
Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …
Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova
Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova
Bioelectrics Publications
Background/Objectives: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis and limited treatment options, highlighting the need for reliable preclinical models for translational research. Although xenograft models are widely used in cancer biology, systematic characterization of subcutaneous ESCC models under defined implantation conditions remains limited. The objective of this study was to systematically compare implantation conditions and define histopathological and growth-related parameters that enable reproducible tumor establishment while maintaining a practical experimental window for therapeutic studies. Methods: We established and characterized a subcutaneous ESCC xenograft model using human ESCC cell line KYSE-30 implanted into immunodeficient J:NU mice. …
Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo
Bioelectrics Publications
Nanosecond electric pulses (nsEPs) are an emerging pulsed-power technology with unique bioelectric characteristics distinct from conventional long-pulse electroporation. As a tunable physical modality, nsEPs can modulate intracellular structures, membrane dynamics, and signaling pathways. Increasing evidence supports nsEPs as a promising non-thermal tumor ablation approach due to their high spatial precision, preservation of critical tissue structures, and minimal adverse effects. One of the most significant discoveries associated with nsEP tumor ablation is the induction of potent systemic antitumor immunity, particularly in situ vaccination (ISV) effects and, in some cases, abscopal effects against distant untreated tumors. Substantial evidence demonstrates that nsEPs can …
On The Influence Of Faraday Waves On Transport In Resonant Acoustic Mixing, Preston David Silverstein
On The Influence Of Faraday Waves On Transport In Resonant Acoustic Mixing, Preston David Silverstein
CGU Theses & Dissertations
Resonant acoustic mixing (RAM) uses low frequency high acceleration oscillatory forcing to combine fluids, particles, and powders. Although progress has been in adjacent RAM fields, there are still gaps in understanding how Faraday surface instabilities affect momentum transport to the bulk fluid and particles therein. This work investigates the energy pathways that an oscillatory mixer has and connects surface deformation to bulk rotational flow and particle forcing. This study is conducted in three phases. In phase 1, a thermodynamic first- and second-law analysis couples the surface features with the scale of subsurface rotational features. Experimental surface measurements showed that for …