Digital Commons Network^™

Drainage And Sedimentary Response Of The Northern Andes And The Pebas System To Miocene Strike-Slip Tectonics: A Source To Sink Study Of The Magdalena Basin, S. Zapata, L. Calderon-Diaz, C. Jaramillo, Francisca Oboh-Ikuenobe, J. C. Piedrahita, M. Rodríguez-Cuevas, A. Cardona, E. R. Sobel, M. Parra, V. Valencia, A. Patiño, J. S. Jaramillo-Rios, M. Flores, J. Glodny

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Miocene strike-slip tectonics was responsible for creating and closing short-lived (ca. 6 Ma) passages and the emergence of isolated topography in the Northern Andes. These geological events likely influenced the migration and/or isolation of biological populations. To better understand the paleogeography of the Miocene hinterland and foreland regions in the Northern Andes, we conducted a source-to-sink approach in the Magdalena Basin. This basin is located between the Central and Eastern Cordilleras of Colombia and contains an ample Miocene record, which includes Lower Miocene fine-grained strata and Middle Miocene to Pliocene coarsening-up strata. Our study presents a new data set that …

3d-Printed Hydrogels Dressings With Bioactive Borate Glass For Continuous Hydration And Treatment Of Second-Degree Burns, Fateme Fayyazbakhsh, Michael J. Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, Ming-Chuan Leu

Biological Sciences Faculty Research & Creative Works

Recent advances in additive manufacturing have led to the development of innovative solutions for tissue regeneration. Hydrogel materials have gained significant attention for burn wound treatment in clinical practice among various advanced dressings due to their soothing and moisturizing activity. However, prolonged healing, pain, and traumatic removal due to the lack of long-term wound hydration are some of the challenges in the treatment of second-degree burn wounds. In this study, 3D-printed dressings were fabricated using gelatin, alginate, and bioactive borate glass (BBG) using an extrusion-based bioprinter. After ionic crosslinking, the 3D-printed dressings were characterized for mechanical properties, degradation rate, hydration …

Study Of Legionella Pneumophila Treatment With Copper In Drinking Water By Single Cell-Icp-Ms, Lei Xu, Austin Sigler, Anna Chernatynskaya, Lindsey Rasmussen, Jingrang Lu, Endalkachew Sahle-Demessie, David J. Westenberg, Hu Yang, Honglan Shi

Biological Sciences Faculty Research & Creative Works

Legionella pneumophila is a persistent opportunistic pathogen that poses a significant threat to domestic water systems. Previous studies suggest that copper (Cu) is an effective antimicrobial in water systems. A rapid and sensitive quantification method is desired to optimize the conditions of L. pneumophila treatment by Cu and to better understand the interaction mechanisms between Cu and cells. In this study, we developed a highly sensitive single cell (SC)-ICP-MS method to monitor L. pneumophila cell concentration and track their uptake of Cu. The SC-ICP-MS method showed excellent sensitivity (with a cell concentration detection limit of 1000 cells/mL), accuracy (good agreement …

Quantum Computing And Its Applications In Healthcare, Vu Giang

OUR Journal: ODU Undergraduate Research Journal

This paper serves as a review of the state of quantum computing and its application in healthcare. The various avenues for how quantum computing can be applied to healthcare is discussed here along with the conversation about the limitations of the technology. With more and more efforts put into the development of these computers, its future is promising with the endeavors of furthering healthcare and various other industries.

Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl

Browse all Theses and Dissertations

Ras proteins are small GTPases that regulate cell proliferation, differentiation and survival at the plasma membrane (PM). There are three Ras isoforms ubiquitously expressed in mammalian cells: H-, N- and K-Ras. Constitutively active Ras mutations are found in ~19% of all human cancers, with ~75% of those being in K-Ras. There are K-Ras inhibitors in clinic but they only target the oncogenic K-RasG12C mutant, which only makes up a small sub-set of K-Ras-driven cancers. Thus, there still exists a need for a pan anti-K-Ras drug. Ferrocene derivatives are a class of compounds that have been shown to inhibit the growth …

Data-Driven Strategies For Pain Management In Patients With Sickle Cell Disease, Swati Padhee

Browse all Theses and Dissertations

This research explores data-driven AI techniques to extract insights from relevant medical data for pain management in patients with Sickle Cell Disease (SCD). SCD is an inherited red blood cell disorder that can cause a multitude of complications throughout an individual’s life. Most patients with SCD experience repeated, unpredictable episodes of severe pain. Arguably, the most challenging aspect of treating pain episodes in SCD is assessing and interpreting the patient’s pain intensity level due to the subjective nature of pain. In this study, we leverage multiple data-driven AI techniques to improve pain management in patients with SCD. The proposed approaches …

Pharmacy Students' Perception And Satisfaction With Chemistry Education: A Crosssectional Study, Fayssal Jhilal, Lamia Slimani, Lamia Zaari Lambarki, Ali Jafri, Samy Iskandar, Mariam El Jemli, Najib Alidrissi, Samir Ahid

Health Sciences

Chemistry is an important part of the curriculum for pharmacy students, as there are many disciplines within chemistry that are actually involved in the design and development of drugs, namely; general chemistry, synthetic organic chemistry, analytical chemistry, biochemistry, pharmaceutical chemistry (or therapeutic chemistry), pharmacognosy and materials chemistry for the design of dosage forms. The learning of chemistry by pharmacy students is generally influenced by their perception of theoretical courses, tutorials or practical work. In order to evaluate this perception, we conducted a cross-sectional study based on an anonymous electronic questionnaire distributed to students of all the Moroccan Faculty of Pharmacy …

Instrumental Fracture In Endodontics: A Short Review, Fatima Zohra Rouggani, Ayoub Belkamel

Health Sciences

Oneofthemostfrequentaccidentsthattakeplaceduringstandardendodontictreatment is instrument fracture. The fractured instrument such as a metallic obstruction inthe root canal system, hinders cleaning and shaping operations, and affects the effectivenessofendodontictherapy.Themanagementofinstrumentfracture,factorsthataffe ctinstrumentfracture,andprecautionsforinstrumentfracturearethethreeheadingsusedtoel aborateonthistopicin thisreview.

Emotions In Engineering Education (Chapter 8), James L. Huff Ph.D., Johanna Lonngren, Ines Dirieto, Roland Tormey

Faculty Research and Publications

Contrary to common stereotypes, engineering education and practice are not purely rational activities. Emotions, just like cognition, play important roles in teaching, learning, and professional practice. Today, there is a nascent body of research exploring emotions in engineering education (EEE). However, much of the existing research does not adequately theorize emotions, and the range of theories and methods used is still relatively narrow. With this chapter, we hope to inspire more investigators to conduct EEE research and to explore currently underutilized theories, methods, and research foci. This chapter introduces the reader to the multidisciplinary field of emotion research, then focus …

The Combination Of Activated Sludge And A Constructed Wetland For Treating Soybean Wastewater, Tri Nguyen Minh, Nhan Nguyen Thi, Hoan Le Thi-Hai, Thanh Pham Van

Applied Environmental Research

Soybean is a nutritious and popular material in the Vietnamese food industry. Soybean processing wastewater contains a significant amount of organic compounds, which have a negative impact on aquatic life due to light penetration and oxygen consumption limitations. Therefore, this study was carried out to determine whether the combination of activated sludge and a constructed wetland using VA06 grass could be effective in treating soybean wastewater. Various amounts of activated sludge were investigated. To be specific, a 20% additional sludge percentage resulted in the shortest treatment time for chemical oxygen demand (COD), total nitrogen (TN), and phosphorus (TP). Additionally, the …

Riverine Microplastics Pollution In Vietnam: A Review Of Current Scientific Knowledge And Legal Policies, Sang Truong Tran Nguyen, Emilie Strady, Thuy Chung Kieu Le, Thi Minh Tam Le, Phuoc Dan Nguyen, Ngoc Bao Pham, Yukako Inamura

Applied Environmental Research

Plastic litter and microplastic pollution in the aquatic environment have become a major concern since scientists, politicians, and citizens began to learn about the impacts in recent years. This in-depth desk review of scientific papers and Vietnamese policies aims to state the current knowledge, legal framework, and action plan relative to microplastic assessment, release, and control in Vietnamese aquatic environments, especially rivers. Regarding scientific literature, this paper focuses on (i) the occurrence of microplastics in riverine surface water and sediments, (ii) the fate and transfer of microplastics in Vietnam’s canals-riverine- estuarine systems, (iii) their accumulation in biota, and (iv) effects …

Developing Cost-Effective Specialty Adsorbents To Meet The Emerging Challenges Of Pollutant Removal In Surface Water Systems, Diana Ordonez

Electronic Theses and Dissertations, 2020-2023

The production of clean water is emphasized under the United Nations goals for sustainable development (SDGs), enlightening the acute need of developing new sustainable technologies in all disciplines. SDGs have urged all engineers in the 21st century to mitigate pollution of drinking water sources and prevent all receiving waterbodies from the impact of agriculture discharge, wastewater effluent, and stormwater runoff. Current water matrix constituents of concern include traditional pollutants (i.e., total nitrogen and total phosphate), natural organic matters (i.e., total organic carbon (TOC), tannic acid), heavy metals (i.e., copper, calcium), and harmful algae toxins (i.e., microcystin), as well as contaminants …

Auto-Ignition Characteristics Of Hydrogen Enriched Natural Gas For Gas Turbine Applications, Christopher T. Loving

Graduate Thesis and Dissertation 2023-2024

A successful transition to clean energy hinges on meeting the world's growing energy demand while reducing greenhouse gas emissions. Achieving this will require significant growth in electricity generation from clean and carbon-free energy sources. Several energy providers have already begun the transition from traditional carbon-based fuels to cleaner alternatives, such as hydrogen and hydrogen enriched natural gas. However, there are still many technical challenges that must be addressed when applying these fuels in gas turbines. The application of hydrogen or hydrogen/natural gas blends to advanced class gas turbines, which have higher operating pressures and temperatures has raised concerns about the …

Predicting Engineering Integration In K-12 From The Perspective Of Pre-Service Teachers, Pilar Pazos, Francisco Cima, Jennifer Kidd, Kristie Gutierrez, Dorothy Faulkner, Minjung Lee, Krishna Kaipa, Orlando Ayala

Engineering Management & Systems Engineering Faculty Publications

The integration of engineering content at the pre-college level is gaining global traction as a strategy to improve learning outcomes and to promote inclusion and diversity in STEM (Science, Technology, Engineering, and Mathematics). Preservice teacher (PST) programs have become natural insertion points for integration efforts by providing future K-12 teachers with the resources and preparation to teach engineering as part of their academic preparation. There is a need to understand the socio-cognitive mechanisms by which teacher preparation programs can help teachers to integrate engineering in their future classrooms. This work examines how an innovative cross-disciplinary program impacted important social-cognitive drivers …

Radiation Shielding Effectiveness Of Hafnium Diboride (Hfb2) Reinforced Epoxy Composites For Enhanced Radiation Protection And Safety, Furkan Erdogan

Theses and Dissertations

This thesis investigates the radiation shielding effectiveness of hafnium diboride (HfB2) reinforced epoxy composites, with the aim of enhancing radiation protection and safety in various applications. The study focuses on the development and characterization of HfB2-epoxy composites with varying weight percentages of HfB2 nanoparticles, as well as on the evaluation of their shielding effectiveness against gamma rays and thermal neutrons. The radiation shielding performance of the composites is assessed using gamma-ray spectroscopy and neutron counting, and the neutron attenuation efficacy is compared with that of 5% borated high-dense polyethylene. The results indicate that the HfB2-epoxy composites exhibit promising radiation shielding …

Show-Me Resilience: Assessing And Reconciling Rural Leaders’ Perceptions Of Climate Resilience In Missouri, Zachary J. Miller, Caleb O'Brien, Casey I. Canfield, Lauren Sullivan

Engineering Management and Systems Engineering Faculty Research & Creative Works

Rural areas of the United States play a vital role in coping with, adapting to and mitigating climate change, yet they often lag urban areas in climate planning and action. Rural leaders—e.g., policymakers, state/federal agency professionals, non-profit organization leadership, and scholars – are pivotal for driving the programs and policies that support resilient practices, but our understanding of their perspectives on climate resilience writ large is limited. We conducted semi-structured interviews with 23 rural leaders in Missouri to elucidate their conceptualizations of climate resilience and identify catalysts and constraints for climate adaptation planning and action across rural landscapes. We investigated …

Antioxidant Theranostic Copolymer-Mediated Reduction In Oxidative Stress Following Traumatic Brain Injury Improves Outcome In A Mouse Model, Aria W. Tarudji, Connor C. Gee, Hunter A. Miller, Rylie Steffen, Evan T. Curtis, Aaron M. Priester, Anthony J. Convertine, Forrest M. Kievit

Materials Science and Engineering Faculty Research & Creative Works

Following a traumatic brain injury (TBI), excess reactive oxygen species (ROS) and lipid peroxidation products (LPOx) are generated and lead to secondary injury beyond the primary insult. A major limitation of current treatments is poor target engagement, which has prevented success in clinical trials. Thus, nanoparticle-based treatments have received recent attention because of their ability to increase accumulation and retention in damaged brain. Theranostic neuroprotective copolymers (NPC3) containing thiol functional groups can neutralize ROS and LPOx. Immediate administration of NPC3 following injury in a controlled cortical impact (CCI) mouse model provides a therapeutic window in reducing ROS levels at 2.08–20.83 …

Demonstration Of High Detoxification Efficiency Of Glassy Polymer-Metal Hydroxide Composites Toward Chemical Warfare Agent Simulants, Peter O. Aina, Sukanta K. Mondal, Joshua Costain, Ali A. Rownaghi, Fateme Rezaei

Chemical and Biochemical Engineering Faculty Research & Creative Works

The design and development of polymeric composites that can effectively capture and destruct toxic chemicals with a fast detoxification rate is of high importance for protecting the military, first responders, and civilians. Here we report the synthesis and assessment of zirconium hydroxide (Zr (OH)4)-incorporated Ultem, Matrimid, and PIM-1 composites for detoxification of dimethyl 4-nitrophenylphosphonate (DMNP), as a type G toxic nerve agent simulant. Maintaining homogeneity, three different loadings (8, 20, 30 wt %) of Zr (OH)4 were incorporated into the polymers, and the thin films of composite materials were developed for subsequent hydrolysis tests. Our results indicated that increasing the …

Reactive Oxygen Species (Ros)-Responsive Size-Reducible Nanoassemblies For Deeper Atherosclerotic Plaque Penetration And Enhanced Macrophage-Targeted Drug Delivery, Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu

Chemical and Biochemical Engineering Faculty Research & Creative Works

Nanoparticle-Based therapeutics represent potential strategies for treating atherosclerosis; however, the complex plaque microenvironment poses a barrier for nanoparticles to target the dysfunctional cells. Here, we report reactive oxygen species (ROS)-responsive and size-reducible nano assemblies, formed by multivalent host-guest interactions between β-cyclodextrins (β-CD)-anchored discoidal recombinant high-density lipoprotein (NP3ST) and hyaluronic acid-ferrocene (HA-Fc) conjugates. the HA-Fc/NP3ST nano assemblies have extended blood circulation time, specifically accumulate in atherosclerotic plaque mediated by the HA receptors CD44 highly expressed in injured endothelium, rapidly disassemble in response to excess ROS in the intimal and release smaller NP3ST, allowing for further plaque penetration, macrophage-targeted cholesterol efflux and …

Exposure To Pcb126 During The Nursing Period Reversibly Impacts Early-Life Glucose Tolerance, Brittany B. Rice, Keegan W. Sammons, Sara Y. Ngo Tenlep, Madeline T. Weltzer, Leryn J. Reynolds, Cetewayo S. Rashid, Hollie I. Swanson, Kevin J. Pearson

Human Movement Studies & Special Education Faculty Publications

Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight via oral gavage on postnatal …

Microcrystalline Dolomite In A Middle Permian Volcanic Lake: Insights On Primary Dolomite Formation In A Non-Evaporitic Environment, Xin Jiao, Yi Qun Liu, Wan Yang, Hong Li, Zi Yuan Meng, Min Ru Zhao, Zhe Xuan Li

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Lacustrine dolomite nucleation commonly occurs in modern and Neogene evaporitic alkaline lakes. As a result, ancient lacustrine microcrystalline dolomite has been conventionally interpreted to be formed in evaporitic environments. This study, however, suggests a non-evaporitic origin of dolomite precipitated in a volcanic–hydrothermal lake, where hydrothermal and volcanic processes interacted. The dolomite occurs in lacustrine fine-grained sedimentary rocks in the middle Permian Lucaogou Formation in the Santanghu intracontinental rift basin, north-west China. Dolostones are composed mainly of nano-sized to micron-sized dolomite with a euhedral to subhedral shape and a low degree of cation ordering, and are interlaminated and intercalated with tuffaceous …

Electroanalytical Investigations Of Microrna-Conjugated Cerium Oxide Based Nanomaterials For Biomedical Applications, Chaimae El Ghzaoui

Electronic Theses and Dissertations, 2020-2023

Diabetes patients are increasingly suffering from wound-healing impairments coupled with other severe medical conditions. High levels of oxidative stress and proinflammatory cytokines are predominant pathologic characteristics of diabetic wounds. Applying microRNA (miRNA) in gene therapy often successfully treats various disorders by generating highly specific bio-responses. Studies revealed that microRNA146a (miR146a), a regulator of inflammation, is downregulated in diabetic wounds. However, miR203 is found to be highly-expressed in diabetic foot ulcers in positive correlation with disease severity. We have synthesized Cerium oxide nanoparticles (CNPs) since they are used in various biomedical applications due to their high enzyme-mimetic activities and reactive oxygen …

A Bim-Based Digital Platform For Assessing The Whole Building Circularity Indicators Of Modular Steel Projects, Yin Min Maung

Chulalongkorn University Theses and Dissertations (Chula ETD)

The construction industry is undergoing a paradigm shift towards sustainable practices, one of which is circular economy (CE). Adopting the CE concept is a complex undertaking, which is characterized by a set of indicators capturing its key aspects. Various tools and techniques are employed to implement this novel concept. An essential step of CE implementation is evaluating the circularity of buildings. This research develops a BIM-based digital platform for assessing the whole building circularity indicators (WBCI) of modular steel projects. The platform is designed to assist in computing these indicators, which requires diverse data inputs and complex interrelated equations. The …

Implementing The Circular Economy Concept In Construction Supply Chain Management Of Modular Steel Projects, Thet Htar San

Chulalongkorn University Theses and Dissertations (Chula ETD)

The circular economy is a modern economic model where the value of products, materials, and resources is maintained in the economy as long as possible, whereas the generation of waste is minimized. The current linear take-make-dispose model prevalent in construction supply chain management is increasingly unsustainable, marked by significant resource wastage and environmental impacts. The conventional linear supply chain models in modular steel construction contribute to unsustainable resource utilization and environmental impacts. This research explores the transition from linear to circular supply chain models. We identify key actors, potential barriers, and opportunities for implementing circular economy practices in modular steel …

The Need For International Ai Activities Monitoring, Parviz Partow-Navid, Ludwig Slusky

Journal of International Technology and Information Management

This paper focuses primarily on the need to monitor the risks arising from the dual-use of Artificial Intelligence (AI). Dual-use AI technology capability makes it applicable for defense systems and consequently may pose significant security risks, both intentional and unintentional, with the national and international scope of effects. While domestic use of AI remains the prerogative of individual countries, the unregulated and nonmonitored use of AI with international implications presents a specific concern. An international organization tasked with monitoring potential threats of AI activities could help defuse AI-associated risks and promote global cooperation in developing and deploying AI technology. The …

Extracellular Vesticles In Acute Respiratory Distress Syndrome: Understanding Protective And Harmful Signaling For The Development Of New Therapeutics, Matthew Bavuso, Noel Miller, Joshua M. Sill, Anca Dobrian, Ruben M. L. Colunga Biancatelli

Bioelectrics Publications

Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more …

Interactions Of Carboxylated Nanodiamonds With Mouse Macrophages Cell Line And Primary Cells, Maisoun Bani-Hani, Stephen J. Beebe, Michael W. Stacey, Christopher Osgood

Bioelectrics Publications

Nanodiamonds (ND) have attracted significant interest for their use in several biomedical applications. These applications can be very useful if the safety and compatibility of ND are proven. We assessed the effects of ND (100 nm, Carboxylated) on primary macrophages and a macrophage-like cell line and found that these particles are not toxic to these cells at lower concentrations but may interfere with cell functions and differentiation. Internalization of ND by these cells in a time- and dose-dependent manner was mostly via phagocytosis and clathrin-dependent endocytosis and localized to the cytoplasm but not into the nucleus. No significant induction of …

Pulsed Electric Field Ablation Of Esophageal Malignancies And Mitigating Damage To Smooth Muscle: An In Vitro Study, Emily Gudvangen, Uma Mangalanathan, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Andrei G. Pakhomov

Bioelectrics Publications

Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effects. We compared cell killing efficiency by PEF (100 pulses, 200 ns–10 µs duration, 10 Hz) in a panel of human esophageal cells (normal and pre-malignant epithelial and smooth muscle). Normal epithelial cells were less sensitive than the pre-malignant ones to unipolar PEF (15–20% higher LD50, p < 0.05). Smooth muscle cells (SMC) oriented randomly in the electric field were more sensitive, with 30–40% lower LD50 (p < 0.01). Trains of ten, 300-ns pulses at 10 kV/cm caused twofold weaker electroporative uptake of YO-PRO-1 dye in normal epithelial cells than in either pre-malignant cells or in SMC oriented perpendicularly to the field. Aligning SMC with the field reduced the dye uptake fourfold, along with a twofold reduction in Ca²⁺ transients. A 300-ns pulse induced a twofold smaller transmembrane potential in cells aligned with the field, making them …

Techno-Economic Analysis Of A Utility-Scale Solar Power Plant In Bhutan., Minjur

Cal Poly Humboldt theses and projects

Solar Photovoltaic (PV) technology, which captures energy from the sun, is a rapidly growing technology. Bhutan’s heavy dependence on a single energy source, hydropower, has become a significant concern for energy security. To address this, the Government of Bhutan intends to diversify energy sources using alternative renewable sources.

This research determined that Bhutan has the total potential to develop 3 gigawatts (GW) of solar power based on the utilization of about 7,100 acres of suitable land. The study also identified Tenchhekha, near the capital city of Thimphu, as a potential solar power plant location, with a capacity of 4.85 MWp …

การประเมินประสิทธิภาพของอาคารเขียว: กรณีศึกษาในกรุงเทพมหานครและปริมณฑล, นภัสสร แพรกอุดม

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยฉบับนี้มีจุดประสงค์เพื่อประเมินประสิทธิภาพด้านคุณภาพของสภาวะแวดล้อมภายในอาคารของอาคารเขียวและอาคารสำนักงานทั่วไปในกรุงเทพมหานครและปริมณฑล และประเมินค่าใช้จ่ายด้านการใช้พลังงานของระบบระบายอากาศและระบบปรับอากาศภายในอาคาร โดยดำเนินการตรวจวัดทั้งเชิงวัตถุวิสัยและตรวจวัดเชิงอัตวิสัย ภายในอาคารเขียว 3 อาคาร และอาคารสำนักงานทั่วไป 1 อาคาร โดยใช้เครื่องมือตรวจวัดคุณภาพอากาศภายในอาคารและแบบสอบถาม จากการศึกษาแสดงให้เห็นว่ามีความแตกต่างกันของผลการตรวจวัดอย่างมีนัยสำคัญหว่างอาคารเขียว และผลการตรวจวัดในบางอาคารเกินค่าเฝ้าระวังฯ โดยเฉพาะ PM2.5 (16.67-40.26 µg/m3) เนื่องจากมลพิษภายนอกอาคารและพฤติกรรมของผู้ใช้อาคาร ผลจากแบบประเมินแสดงให้เห็นว่าผู้ใช้อาคารส่วนมากพึงพอใจกับคุณภาพของสภาวะแวดล้อมโดยรวม ส่วนข้อมูลผลกระทบทางสุขภาพวิเคราะห์โดยใช้ Odd Ratio พบว่า ผู้ใช้อาคารที่มีระดับมลพิษสูงมีโอกาสเกิดอาการทางสุขภาพมากกว่าผู้ใช้อาคารที่ได้รับสัมผัสในระดับที่ต่ำกว่า ในส่วนของค่าไฟฟ้าจากระบบปรับอากาศ อาคารสำนักงานทั่วไปมีค่าสูงที่สุดเมื่อเปรียบเทียบกับอาคารเขียว โดยการบริหารจัดการอาคารที่ไม่เหมาะสมและนโยบายการประหยัดพลังงานที่ไม่มีประสิทธิภาพอาจส่งผลกรทบต่อคุณภาพของสภาวะแวดล้อมภายในอาคารให้แย่ลงได้ โดยสรุป คุณภาพอากาศภายนอกอาคารและพฤติกรรมของผู้ใช้อาคารเป็นปัจจัยสำคัญที่ส่งผลกระทบต่อประสิทธิภาพของอาคารในด้านคุณภาพของสภาวะแวดล้อมภายในอาคารของอาคารเขียวได้