Digital Commons Network^™

Disordered Speech Assessment Using Automatic Methods Based On Quantitative Measures, Lingyun Gu, John G. Harris, Rahul Shrivastav, Christine Sapienza

Electrical and Computer Engineering Faculty Research & Creative Works

Speech quality assessment methods are necessary for evaluating and documenting treatment outcomes of patients suffering from degraded speech due to Parkinson's disease, stroke, or other disease processes. Subjective methods of speech quality assessment are more accurate and more robust than objective methods but are time-consuming and costly. We propose a novel objective measure of speech quality assessment that builds on traditional speech processing techniques such as dynamic time warping (DTW) and the Itakura-Saito (IS) distortion measure. Initial results show that our objective measure correlates well with the more expensive subjective methods. © 2005 Hindawi Publishing Corporation.

Auto-Pipe: A Pipeline Design And Evaluation System, Mark A. Franklin, John Maschmeyer, Eric Tyson, James Buckley, Patrick Crowley

All Computer Science and Engineering Research

Auto-Pipe is a tool that aids in the design, evaluation, and implementation of pipelined applications that are distributed across a set of heterogeneous devices including multiple processors and FPGAs. It has been developed to meet the needs arising in the domains of communications, computation on large datasets, and real time streaming data applications. In this paper, the Auto-Pipe design flow is introduced and two sample applications, developed for compatibility with the Auto-Pipe system, are presented. The sample applications are the Triple-DES encryption standard and a subset of the signal-processing pipeline for VERITAS, a high-energy gamma-ray astrophysics experiment. These applications are …

Stable Polymer Micelle Systems As Anti-Cancer Drug Delivery Carriers, Yi Zeng

Theses and Dissertations

Several temporarily stable polymer micelle systems that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were Plurogel®, Tetronic®, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactaten). In previous work in our lab, Pruitt et al. developed a stabilized drug carrier named Plurogel® [5, 6]. Unfortunately, the rate of the successful Plurogel® synthesis was only about 30% by simply following Pruitt's process. In this work, this rate was improved to 60% by combining the process of adding 0.15 M NaCl and/or 10 µl/ml n-butanol and by preheating the solution before polymerization. Tetronics® were proved not …

Finite Element Analysis Of Covered Microstents, Linxia Gu, Swadeshmukul Santra, Robert A. Mericle, Ashok V. Kumar

Department of Mechanical and Materials Engineering: Faculty Publications

Currently available neuroendovascular devices are inadequate for effective treatment of many wide-necked or fusiform intracranial aneurysms and intracranial carotid-cavernous fistulae (CCF). Placing a covered microstent across the intracranial aneurysm neck and CCF rent could restore normal vessel morphology by preventing blood flow into the aneurysm lumen or CCF rent. To fabricate covered microstents, our research group has developed highly flexible ultra thin (~150 μm) silicone coverings and elastomerically captured them onto commercially available metal stents without stitching. Preliminary in vivo studies were conducted by placing these covered microstents in the common carotid artery of rabbits. The feasibility of using covered …

Substrate-Mediated Gene Delivery For Assessment Of Signal Transduction Pathways In Cancer Cells, Angela K. Pannier, Zain Bengali, Eric A. Ariazi, V. Craig Jordan, Lonnie D Shea

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Gene delivery has the potential to be used in diagnostic applications, specifically to investigate cellular signal transduction pathways responsible for disease. Analysis of multiple pathways or genes in a parallel format can be achieved using a transfected cell array, a high throughput approach to correlate gene expression with functional cell responses, based on gene delivery from a substrate that supports cell adhesion. Substrate-mediated gene delivery functions by self-assembling DNA with nonviral vectors, resulting in positively charged complexes that can interact with a biomaterial or substrate. Cells cultured on the substrate are exposed to elevated DNA concentrations within the local microenvironment, …

Laurance Lake Temperature Model, Chris Berger, Scott A. Wells, Robert Leslie Annear

Civil and Environmental Engineering Faculty Publications and Presentations

Laurance Lake is a reservoir located in Hood River County, Oregon (Figure 1). It is located at the base on Mt. Hood in Oregon (see Figure 2 and Figure 3), discharges into the Middle Fork of the Hood River. The reservoir was constructed in 1968 for irrigation storage and has a capacity 3564 acre- feet at full pool. Since the river vio lates temperature standards, this study has been designed to construct a hydrodynamic and temperature model of Laurance reservoir in order to assess strategies for improving temperatures in the Middle Fork River.

The objectives of the study are then …

A Cartilage Growth Mixture Model For Infinitesimal Strains: Solutions Of Boundary-Value Problems Related To In Vitro Growth Experiments, Stephen M. Klisch, Robert L. Sah, Anne Hoger

Mechanical Engineering

A cartilage growth mixture (CGM) model is linearized for infinitesimal elastic and growth strains. Parametric studies for equilibrium and nonequilibrium boundary-value problems representing the in vitro growth of cylindrical cartilage constructs are solved. The results show that the CGM model is capable of describing the main biomechanical features of cartilage growth. The solutions to the equilibrium problems reveal that tissue composition, constituent pre-stresses, and geometry depend on collagen remodeling activity, growth symmetry, and differential growth. Also, nonhomogeneous growth leads to nonhomogeneous tissue composition and constituent pre-stresses. The solution to the nonequilibrium problem reveals that the tissue is nearly in equilibrium …

Characterization Of A Rotary Flat Tail As A Spoiler And Parametric Analysis Of Improving Directional Stability In A Portable Uav, Troy A. Leveron

Theses and Dissertations

The United States Air Force Research Lab, Munitions Directorate, Flight Vehicles, Integration Branch (AFRL/MNAV), has developed a flexible wing micro air vehicle (MAV) to be used with special tactics groups. In keeping with the requirement that this MAV be compact, previous research developed a rotatable tail mechanism which resulted in tail movement similar to that of a bird's tail. In this study the design of this tail was modified to produce a more storable vehicle. The redesign also allowed the tail to deflect upward to large angles, enabling the tail to be used as a spoiler. The aerodynamic effects of …

Dynamic Matrix Composition In Engineered Cartilage With Stochastic Supplementation Of Growth Factors, Asit K. Saha, J. (Jagannath) Mazumdar, Sean S. Kohles

Mechanical and Materials Engineering Faculty Publications and Presentations

Dynamic extracellular matrix (ECM) synthesis is explored in a hypothesized engineered cartilage construct. Growth (α) and decay (β) rate parameters are developed from a previous engineered cartilage model. The presented mathematical model was constructed from the parameterized experimental data using a deterministic and stochastic examination of ECM synthesis based on a negative feedback control mechanism. A growth factor supplementation is incorporated in a probabilistic mathematical approach. The growth factor component modified an initial deterministic model through a Gaussian white noise fluctuation. As the primary constituents of ECM, the mathematical tool is intended to characterize the probable steady state distribution of …

Optimization Of Sequential Purification Of Beta-Glucosidase From Tricoderma Reesei In Aqueous Two-Phase System, Shalini Gautam

Dissertations

A novel sequential technique was developed for the purification of a valuable enzyme, beta-glucosidase, from microorganism Tricoderma reesei. The fungus T. reesei produces cellulose degrading enzymes, called cellulases: beta-glucosidase, endo-glucanase and exo-glucanase and low molecular weight proteins. For specific applications, the enzyme must be separated from other contaminants. The sequential technique, that included affinity precipitation with chitosan followed by separation with an aqueous two-phase system (ATPS), was implemented for the purification of beta-glucosidase from the culture filtrate of T. reesei.

The cultivation medium (nutrient) was optimized for the production of betaglucosidase from T. reesei cell culture. Treatment of the …

Nanostructured Composite Materials Based On Carbon Nanotubes And 3-D Photonic Crystals, Jing Chen

Dissertations

Carbon nanotubes (CNT) and in particular, single-wall carbon nanotubes (SWCNT) have been extensively studied, in large part, due to their unique one-dimensional crystalline structures and related electronic and optical properties. Various polymeric composite materials, which were based on carbon nanotubes, have been also developed in an attempt to combine the properties of polymer and CNT in a single film. Such composites were mainly formed by mixing carbon nanotubes within the polymer without special emphasis on the structure and thereby, the nanoscopic properties of the resultant material.

Photonic crystals belong to a class of man-made structures aimed at manipulating the propagation …

Development Of Adsorption Filtration Process For Virus Removal For Drinking Water Treatment, Vishal Vijay Gawarikar

Dissertations

Recent monitoring studies have indicated that many ground water (GW) sources would benefit from the development of effective technologies for removing viruses. Although reverse osmosis can achieve high log removal it is not economical. The main objective of this study is to test and validate a novel adsorption filtration (AF) technology for removing viruses from GW sources for drinking water production in New Jersey.

The convective diffusion of viruses to adsorbent particle surfaces in flow packed beds (FPB) enhances their removal efficiency if the adsorbent particle size can be decreased to about 100 microns. The development of effective virus removal …

Mechanics Of Biocell Landfill Settlements, Chamil Hiroshan Hettiarachchi

Dissertations

Prediction of landfill gas generation and settlements are of concerns in design and maintenance of biocell landfills. Accurate settlement prediction is essential for design of piping systems used for the delivery of re-circulated leachate and recovery of landfill gas. Landfill settlement is the result of change in overburden stresses and biodegradation of waste. Biodegradation-induced settlement results from the re-arrangement of waste skeleton in response to the decomposition of waste mass.

Current practice of landfill settlement modeling is predominantly empirical, thus most of the available techniques make no attempt to simulate the real mechanisms of waste settlement. Traditionally compressibility index is …

Direct Numerical Simulations And Experimental Investigation Of Dielectrophoresis, Arun Thankamony John-Kadaksham

Dissertations

This dissertation deals with the numerical and experimental studies of the phenomenon of dielectrophoresis, i.e., the motion of neutral particles in nonuniform electric fields. Dielectrophoresis is the translatory motion of neutral particles suspended in a dielectric medium when they are subjected to an external nonuniform electric field. The translatory motion occurs because a force called the dielectrophoretic force, which depends on the spatial variation of the electric field, acts on the particles. As the generation of force involves no moving parts and the particles can be moved without touching them, dielectrophoresis can be used in many applications, including manipulation and …

Simulation Of Creep In Nickel Based Single Crystal Superalloys, Yunhong Pang

Dissertations

Nickel based single crystal Superalloys are finding wide spread use in high temperature gas turbines and other similar applications because of their superior high-temperature strength and creep properties as compared to the other materials. This is due to two factors: solid solution and precipitation strengthening of the gamma (γ) and gamma prime (γ') phases, and the elimination of grain boundaries. Creep of Nickel based single crystal Superalloys are caused by two primary mechanisms, dislocation creep and diffusion creep. Several factors that affect the creep life of Nickel based single crystal Superalloys are the specific microstructure, stress, temperature and rafting. Also, …

Characterization Of Mismatch Between Behavioral Stimuli And Frmi Data Using The Kalman Filter, Jason Steffener

Dissertations

The advance of blood oxygen level dependent function magnetic resonance imaging, (BOLD fMRI), allows researchers to non-invasively investigate the functioning human brain. The BOLD fMRI response to brief stimuli is called the hemodynamic response function (HRF), which can vary across brain regions and across subjects.

Models of the HRF are used to increase sensitivity of statistical maps; however, they often don't account for spatial and temporal variance. Physiological effects, such as learning, fatigue or habituation, introduce mismatch between statistical models and the data. Methods that use minimal a priori information and track time varying signals are able to show the …

Utility Of Remote Sensing Data In Retrieval Of Water Quality Consituents Concentrations In Coastal Water Of New Jersey, Ting Yu

Dissertations

Three important optical properties used for monitoring coastal water quality are the concentrations of chlorophyll (CHL), color dissolved organic matter (CDOM) and total suspended materials (TSM). Ocean color remote sensing, a technique to collect color data by detection of upward radiance from a distance (Bukata et al.,1995), provides a synoptic view for determining these concentrations from upwelling radiances. In the open ocean (Case-I), it is not difficult to derive empirical algorithms relating the received radiances to surface concentrations of water quality parameters. In coastal waters (Case-Il), there are serious unresolved problems in extracting chlorophyll concentration because of high concentration of …

Planar Visual Fusion Scintigraphy, Jacob Puthiamadathil

Theses

Planar scintigraphy, while providing useful information about the distribution of the radiopharmaceutical being used, often does not provide adequate information about the surrounding anatomical structures. A proposed method to solve this problem is by registering and fusing a scintigraphic image with a digital visual image. Fusing planar scintigraphic images with visual photographic images to supply an anatomic correlate to regions of radiopharmaceutical accumulation has been explored in this study. The digital visual image will provide a context for the relevant structures in the scintigraphic image. The validity of using one set of affine transformation parameters for registering all patient data …

Analysis Of Acceleration And Deceleration During Cyclic Exercise, Jeena Vadi

Theses

The Cyclic Exercise Protocol is a novel protocol that is designed to create a series of cyclic waves of exercise and recovery. This exercise protocol involves short bursts of exercise lasting for 60 seconds or less followed by a period of complete cardio recovery. This study involves the analysis of the acceleration and the deceleration regions of the cyclic exercise sessions. The objective of this study was to develop an algorithm to quantitatively analyze the acceleration and the deceleration regions of cyclic exercise sessions. The acceleration and the deceleration regions of cycles were split into three segments and each segment …

Enabling Cost Aware Routing With Auctions In Wireless Ad-Hoc Networks, Ali Yuksel

Theses

Battery power is a precious resource in wireless ad-hoc networks, and most routing protocols that have been proposed so far do not generate cost efficient routes. In this thesis, a novel auction-based cost-aware routing scheme, called CARA, is presented. CARA is designed as an extension of the MAC layer, and is shown to improve the cost efficiency of existing ad-hoc routing protocols through dynamic power control, while introducing only minimal additional overhead. The MAC layer at each node is given the capability to run local sealed-bid second-price auctions for the user data packets that need to be transmitted, and to …

Non-Linear Digital Control Of A Mckibben Muscle System, Surinkumar Patel

Theses

McKibben muscles are pneumatic actuators that have potential application in the rehabilitation of persons with physical impairments. These actuators have been known to exhibit similarities in human musculoskeletal systems. In order to better understand and improve the closed - loop control of these pneumatic muscles, a physical joint model was constructed with an agonist and an antagonist muscle operating under non-linear control. With the use of LabVIEW software, compliant McKibben air muscles and Flock-of-Birds sensor, the author was able to implement and compare a standard bang-bang controller and experimental non-linear digital Proportional (P) controller. The feedback mechanism is based on …

Stereo Vision Algorithm Using Propagation Of Correspondences Along An Array Of Cameras, Danyan Ganjali

Theses

One well known problem in stereo vision is the trade-off between precision and accuracy.

In a conventional two camera model, as the baseline separating the two cameras becomes smaller, the images that both cameras produce become more identical. This results in a more accurate set of correspondences, however at the same time causing less precise depth measurement due to the small angle used for triangulation. Similarly, in a larger baseline model, the depth measurement is more precise while the correspondences are not as accurate as of the shorter baseline model. This thesis proposes a method that promises to solve the …

Ambulatory Biopotential Measurement, Lakshmi Chitra Penugonda

Theses

Biopotential signals measure the electrical activity of different parts of the body. Conventional bedside monitors only provide information about the body under restricted conditions. Observation and documentation of biopotential signal during daily activities and the relation to patient symptoms may be important factors for clinical decision-making. Ambulatory monitoring helps to monitor the biopotential signal of a patient in the natural environment. The effective ambulatory system can help a physician to diagnose the patient's abnormality.

In this project, a low cost and flexible ambulatory biopotential system, compared to the commercially available systems, was designed and tested. Concurrently a software program was …

Applications Of Using The Odor Footprint Tool, Richard R. Stowell, L. Koppolu, Dennis D. Schulte, Richard K. Koelsch

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

The Odor Footprint Tool is a science-based computer resource for use in evaluating the potential odor impact of new and expanded animal production facilities. It was developed to assist livestock producers, their service providers, and county planning and zoning officials in making reasonable decisions while limiting the negative impact of livestock operations on surrounding neighbors and rural communities. The Odor Footprint Tool utilizes an EPA regulatory model (AERMOD), weather databases, new source code, and user input to generate regional odor roses, odor footprints, and directional setback distance curves. Odor roses provide a generic picture of the directionality of …

Using Ems’S To Improve Compliance On Livestock And Poultry Operations, L. Mark Risse, Richard K. Koelsch, Bill Bland, Elizabeth A. Bird, Thomas M. Bass

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

Across the United States and abroad, innovative producers, processors, trade organizations and others in the agricultural sector are exploring the promise of Environmental Management Systems (EMS) to improve their environmental and business performance. An Environmental Management System or EMS helps farmers develop their own, personal strategies for reducing environmental risk on their operations by integrating environmental management considerations into production management decisions. It is a voluntary, flexible approach and is based on a producer's own sense of how best to manage an operation.

Partnerships for Livestock Environmental Management Systems is a 4-year project to explore the potential of livestock Environmental …

Fabrication Of Magnetic Hollow Silica Nanospheres For Bioapplications, L. Shao, Dumitru Caruntu, J. F. Chen, C. J. O'Connor, W. L. Zhou

Mechanical Engineering Faculty Publications

Different kinds of nanospheres are used in magnetic nanosphere fabrication for bioapplications. In this paper, we report a successful synthesis of magnetic hollow silica nanospheres (MHSNS). The MHSNS were fabricated with a one step coating of Fe3O4 magnetic nanoparticles (NPs)(∼10nm) and silica on nanosized (20–100nm) spherical calcium carbonate (CaCO3) surface under alkaline conditions, in which the nanosized CaCO3 were used as nanotemplates and tetraethoxysilane and magnetic NPs were used as precursors. The as-synthesized nanoshperes were immersed in an acidic solution to remove nanosized CaCO3, forming MHSNS. The MHSNS were characterized by SEM, TEM, and SQUID. SEM and TEM results showed …

Cellulose Utilization By Clostridium Thermocellum: Bioenergetics And Hydrolysis Product Assimilation, Yi-Heng P. Zhang, Lee R. Lynd

Dartmouth Scholarship

The bioenergetics of cellulose utilization by Clostridium thermocellum was investigated. Cell yield and maintenance parameters, Y(X/ATP)True = 16.44 g cell/mol ATP and m = 3.27 mmol ATP/g cell per hour, were obtained from cellobiose-grown chemostats, and it was shown that one ATP is required per glucan transported. Experimentally determined values for G(ATP)P-T (ATP from phosphorolytic beta-glucan cleavage minus ATP for substrate transport, mol ATP/mol hexose) from chemostats fed beta-glucans with degree of polymerization (DP) 2-6 agreed well with the predicted value of (n-2)/n [corrected] (n = mean cellodextrin DP assimilated). A mean G(ATP)(P-T) value of 0.52 +/- 0.06 was calculated …

Studies On Novel Semiconductor Detectors And Front-End Electronics For Heavy Flavor Decay Studies, Gustavo Kertzscher

Renée Crown University Honors Thesis Projects - All

I have studied novel semiconductor detectors designed to provide precise space point information of the trajectory of charged subatomic particles produced in high energy physics (HEP) collisions. The technological thrust aims toward maintaining good performance of these detectors in a hard radiation environment for an extended period of time. My studies approached two different types of silicon devices: a whole wafer comprised of test structures and pixel devices designed for the inner vertex detector of the BTeV experiment, and small test structures of a novel type of quasi-3D detectors developed in the context of the CERN RD50 collaboration. This collaboration …

Validating Surface Energy Balance Fluxes Derived From Airborne Remote Sensing, José Luis Chávez Egüez

Biological Engineering

Remote sensing-derived energy balance components were compared against measured eddy covariance energy balance terms using heat flux source area models to validate the airborne multispectral remote sensing procedure in the estimation of instantaneous and daily evapotranspiration rates.

A procedure was developed to generate raster layers of the footprint weights for weighting/integrating the different components of the energy balance model and obtain meaningful comparisons to similar energy balance terms measured at eddy covariance and/or Bowen ratio stations.

Soil heat flux and surface aerodynamic temperature models were studied in an effort to improve the remote sensing estimation of distributed evapotranspiration rates. Aerial …

Modeling Of Immunoglobulin Uptake By N,N,N′,N′-Ethylenediaminetetramethylenephosphonic Acid-Modified Zirconia Particles Under Static And Dynamic Conditions, Sabyasachi Sarkar, Anuradha Subramanian

Papers in Biotechnology

A matrix developed from N,N,N′,N′-ethylenediaminetetramethylenephosphonic acid-modified zirconia beads (further referred to as r_PEZ); 25–38 μm in diameter and with a pore size of 22 ± 3 nm, was utilized for the separation of immunoglobulins (Igs). r_PEZ has been shown to bind to various Igs originating from a wide variety of species. To understand the mechanisms controlling the uptake of Igs by r_PEZ, static protein uptake experiments were carried out. The protein uptake profiles were further modeled with a kinetic rate constant model. Individual studies were undertaken for human immunoglobulin A, G and M (HIgA, HIgG and HIgM). The kinetic rate …