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Adaptive Intensity Modulated Radiation Therapy Planning Optimization With Changing Tumor Geometry And Biology Enforcing Both Cumulative And Fraction Size Dose Constraints, Behlul Saka

Graduate Theses and Dissertations

Intensity Modulated Radiation Therapy (IMRT) is a modern technique of delivering radiation treatments to cancer patients. In IMRT technology, intensities must be chosen for the many small unit grids into which the beams are divided to produce a desired distribution of dose at points throughout the body with the goal of maximizing dose delivered to the tumor while sparing healthy tissues from excessive radiation and keeping dose homogeneous across the tumor. Although IMRT plans are optimized as a single overall treatment plan, they are delivered over 30-50 treatment sessions (fractions) and both cumulative and per-fraction dose constraints apply. The extended …

Radio Frequency Micro/Nano-Fluidic Devices For Microwave Dielectric Property Characterizations, Chunrong Song

All Dissertations

In this dissertation, a number of different topics in microwave dielectric property measurements have been covered by a systematic approach to the goals of development of dielectric spectroscopy and study of its high electric field effects with integrated on-chip microwave microfluidic / nanofluidic devices.
A method of parasitic effects cancellation for dielectric property measurement is proposed, analyzed, and experimentally evaluated for microwave characterization of small devices and materials that yield low intensity signals. The method dramatically reduces parasitic effects to uncover the otherwise buried signals. A high-sensitive radio frequency (RF) device is then developed and fabricated to detect small dielectric …

Modeling And Synthesis Of Functionalized Meta-Poly(Phenylene Ethynylene) Helical Structures, Ha Nguyen

All Dissertations

The ability of meta-poly(phenylene ethynylene) (mPPE) materials to undergo random coil to helix conformational changes under select conditions affords many opportunities for their use in sensor, separation, catalysis, and bio-related applications. Thus, to advance the development of these materials, a modeling procedure based on replica exchange molecular dynamics (REMD) simulation was developed to reliably assess factors affecting the folding behaviors of functionalized mPPE variants in solution. A combinational modeling study of 20 functionalized mPPEs in five solvent conditions provided insight into how mPPE secondary structure is impacted by the complex relationship between mPPE functional groups and solvent moieties. Further, these …

Spectral Engineering Of Optical Fiber Through Active Nanoparticle Doping, Tiffany Lindstrom-James

All Dissertations

The spectral engineering of optical fiber is a method of intentional doping of the core region in order to absorb/emit specific wavelengths of light therby providing enhanced performance over current fibers. Efforts here focused on developing an understanding of optically active nanoparticles based on alkaline earth fluorides that could be easily and homogeneously incorporated into the core of a silica based optical fiber preform and result in efficient and tailorable spectral emissions.
Doped and undoped calcium, strontium and barium fluoride nanoparticles were successfully synthesized and characterized for their physical, chemical, and optical behavior. Distinct spectroscopic differences as a result of …

Characterizing Mechanical Heterogeneity In Cardiovascular Cells, Sandra Deitch

All Dissertations

Most tissue-level mechanical models assume homogeneous mechanical properties within a single cell type. However, measurements of cellular mechanical properties show large variability in whole-cell mechanical properties between cells from a single population. This heterogeneity has been observed in many cell populations and with several measurement techniques but the sources are not yet fully understood. Cell mechanical properties are directly related to the composition and organization of the cytoskeleton, which is physically coupled to neighboring cells through adherens junctions and to underlying matrix scaffolds through focal adhesion complexes. As such, we believe that this high level of heterogeneity can be attributed …

Accelerating Pattern Recognition Algorithms On Parallel Computing Architectures, Kenneth Rice

All Dissertations

The move to more parallel computing architectures places more responsibility on the programmer to achieve greater performance. The programmer must now have a greater understanding of the underlying architecture and the inherent algorithmic parallelism. Using parallel computing architectures for exploiting algorithmic parallelism can be a complex task. This dissertation demonstrates various techniques for using parallel computing architectures to exploit algorithmic parallelism. Specifically, three pattern recognition (PR) approaches are examined for acceleration across multiple parallel computing architectures, namely field programmable gate arrays (FPGAs) and general purpose graphical processing units (GPGPUs).
Phase-only filter correlation for fingerprint identification was studied as the first …

Environmental Sensor Anomaly Detection Using Learning Machines, Erick F. Conde

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The search for improvements in the quality assurance/quality control (QA/QC) of real-time environmental measurements has been a field well exploited in recent years. These measurements describe actual environmental conditions and processes that provide relevant information upon which water quality management decisions are based. In situ sensors (located at the site of interest) are commonly used for such real-time measurement purposes. However, the performance of these types of sensors can be affected by such things as human factors, lack of necessary maintenance, flaws on the transmission line or any part of the sensor, and unexpected changes in the sensors surrounding conditions. …

Optimization Of Dissolved Air Flotation For Algal Harvesting At The Logan, Utah Wastewater Treatment Plant, Andrew R. Elder

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Research being completed at the Logan, UT wastewater treatment plant could provide a locally-sourced gasoline replacement by collecting algae that grows naturally. This process would also provide the City of Logan with a method to meet certain standards set by the state of Utah.

Problem and proposed solution:

The water leaving Logan’s wastewater treatment plant has high levels of phosphorus and nitrogen, two elements that are found in all wastewater treatment plants. These two substances need to be controlled, because they kill fish and cause pond scum to grow in recreational reservoirs downstream. A unique method has been found to …

Designing Predictive Mathematical Models For The Metabolic Pathways Associated With Polyhydroxybutyrate Synthesis In Escherichia Coli, Angela Dixon

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Plastics are a versatile and widely used material. However, traditional plastics are derived from petrochemicals and are not biodegradable. Polymers synthesized from microorganisms that have similar properties to plastic are potential biodegradable replacements. The objective of this project is to use mathematical modeling as a tool to engineer a strain of bacteria optimized for the production of bio-plastics.

Production costs can be reduced by using a bacterial strain specifically optimized for bio-plastic production. By reducing production costs, bio-plastics will be able to commercially compete with traditional plastics. Society will benefit as bio-plastics replace traditional plastics. Fossil fuels will not be …

Analysis Of The Import, Export, And Bioavailability Of Nitrogen And Phosphorus Within Pineview Reservoir, Brady K. Worwood

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study was conducted to provide new and useful data about Pineview Reservoir and its watershed, produce water and phosphorus (P) budgets for Pineview Reservoir, test the validity of conclusions made in the Pineview Reservoir Total Maximum Daily Loading (TMDL) document, and create estimates of nitrogen (N) loading to the reservoir from both surface and ground water sources. The production of the water and P budgets, as well as the N loading estimates, was accomplished by measuring flow, nitrate, ammonium, total phosphorus (TP), and soluble reactive phosphorus (SRP) that was entering and exiting the reservoir through surface water sources and …

Optimization Of A Low Reynold's Number 2-D Inflatable Airfoil Section, Todd A. Johansen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A stand-alone genetic algorithm (GA) and an surrogate-based optimization (SBO) combined with a GA were compared for accuracy and performance. Comparisons took place using the Ackley Function and Rastrigin's Function, two functions with multiple local maxima and minima that could cause problems for more traditional optimization methods, such as a gradient-based method. The GA and SBO with GA were applied to the functions through a fortran interface and it was found that the SBO could use the same number of function evaluations as the GA and achieve at least 5 orders of magnitude greater accuracy through the use of surrogate …

Concept Tests For A New Wire Flying Vehicle Designed To Achieve High Horizontal Resolution Profiling In Deep Water, Chris Roman, Dave Hebert

Graduate School of Oceanography Faculty Publications

Efficiently profiling the water column to achieve both high vertical and horizontal resolution from a moving vessel in deep water is difficult. Current solutions, such as CTD tow-yos, moving vessel profilers, and undulating tow bodies, are limited by ship speed or water depth. As a consequence, it is difficult to obtain oceanographic sections with sufficient resolution to identify many relevant scales over the deeper sections of the water column. This paper presents a new concept for a profiling vehicle that slides up and down a towed wire in a controlled manner using the lift created by wing foils. The wings …

A Novel Telecommunications-Based Approach To Mathematical Modeling Of Hiv Infection, Aaron T. Sharp

Department of Computer Electronics and Engineering: Dissertations, Theses, and Student Research

It is well known that biological systems utilize communication in some form, one prolific example of this is the propagation of HIV (Human Immunodeficiency Virus) in the human body. By modeling HIV infection as a communication system, we hope to gain a unique insight into HIV and biological communication systems in general. Such a model would provide researchers a platform for experimenting and simulating various biological communication systems. We have previously developed a layered communication protocol for interpreting biological communication systems using telecommunications paradigms and will apply said model to HIV proliferation. We will also demonstrate the effectiveness of the …

Hydrologic Evaluation Of Established Rain Gardens In Lincoln, Nebraska Using A Storm Runoff Simulator, Andrew R. Anderson

Department of Environmental Engineering: Theses and Other Student Research

Increased urbanization has resulted in water quality and flooding problems for many receiving waters in the United States. Bioretention, or rain gardens, is one of the most widely popular and effective best management practices in low impact development (LID), which strives to return a watershed to a predevelopment hydrologic regime. Many studies have evaluated large bioretention cells in research settings. There is little information on the effectiveness of homeowner-maintained rain gardens that rely on deep percolation as the method for water exfiltration. Additionally, few studies address rain garden performance in cold, arid, or semi-arid climates found in the Midwest U.S. …

Fabrication Of Grooved Hollow Fiber Membrane For Nerve Regeneration: Process Modeling And Performance Evaluation, Jun Yin

All Dissertations

Nerve injury is a general but intractable disease in traumatic injuries, leading to a significant reduction of functions in the nervous system. Extensive efforts are made on nerve injury rehabilitation. Since the appropriate connections between neurons and their targets are necessary, guiding axonal outgrowth is an essential step for neuron outgrowth in nervous system development, functioning, and regeneration. Besides the direct surgical nerve connection, an artificial means of guiding nerve regeneration called nerve conduits is widely applied in nerve injury rehabilitation. The main function of nerve conduits is to bridge the nerve gap, to help regenerating axons across damaged regions …

Highly Conductive Carbon Nanotube Fibers For Biomedical Applications, Vijoya Sa

All Dissertations

We developed a wet spinning process for the formation of polymeric fibers with high loading of single walled carbon nanotubes. The dissertation consists of five chapters. In the first chapter, the research goals were formulated and the art and technologies of fiber spinning from carbon nanotubes were critically analyzed. The next three chapters report the original results. Last chapter summarizes all the findings.
In the second chapter, we describe a surfactant based method of stabilization of carbon nanotube dispersions. The conditions of stability of nanotube dispersions in aqueous solutions of sodium dodecyl sulfate were analyzed. Using surface tension isotherms, the …

Electrical Coupling Between Micropatterned Cardiomyocytes And Stem Cells, Zhen Ma

All Dissertations

To understand how stem cells functionally couple with native cardiomyocytes is crucial for cell-based therapies to restore the loss of cardiomyocytes that occurs during heart infarction and other cardiac diseases. Due to the complexity of the in vivo environment, our knowledge of cell coupling is heavily dependent on cell-culture models. However, conventional in vitro studies involve undefined cell shapes and random length of cell-cell contacts in addition to the presence of multiple homotypic and heterotypic contacts between interacting cells. Thus, it has not been feasible to study electrical coupling corresponding to isolated specific types of cell contact modes.
To address …