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Effects Of Train-Ship Direct Transshipment On Container Terminal Operational Efficiency And Energy Consumption: From A Scheduling Perspective, Yiying Du, Yaozong Wang, Zhongzhen Yang Jan 2025

Effects Of Train-Ship Direct Transshipment On Container Terminal Operational Efficiency And Energy Consumption: From A Scheduling Perspective, Yiying Du, Yaozong Wang, Zhongzhen Yang

Journal of Marine Science and Technology–Taiwan

On-dock rail integration positions terminals as critical hubs for rail-sea transshipment, which necessitates efficient scheduling for rapid container transfers. Given the strict schedules and batch arrival of railway containers, in this study, we propose a train-ship direct transshipment (TSDT) mode to eliminate nonproductive yard rehandling. To comprehensively evaluate the impact of the proposed mode on terminal handling operations, we developed an operational scheduling model for the entire process of the simultaneous loading of yard containers and railway-handling area (RHA) containers. The model comprises two stages. Stage 1 models the pre-reshuffling operations in the yard before loading, and Stage 2 implements …


Key Success Factors In Using The Lifting Method To Construct A Steel Bridge Pylon, Ming-Chao Su, Hui-Ping Tserng Jan 2025

Key Success Factors In Using The Lifting Method To Construct A Steel Bridge Pylon, Ming-Chao Su, Hui-Ping Tserng

Journal of Marine Science and Technology–Taiwan

Constructing the inclined steel pylon of cable-stayed bridges is challenging because of the pylon’s height, spatial limitations, and safety concerns. To address these challenges, this study developed a modular lifting method that can enhance the efficiency and precision of pylon construction. The proposed method involves using rotation jigs to temporarily assemble the pylon, horizontal positioning on temporary supports, and synchronized lifting through computer-controlled hydraulic systems. Field implementation on a large-span bridge project revealed that compared with the traditional method, the proposed method resulted in higher welding quality, lower risks associated with great-height operations, and a shorter on-site assembly time. The …


Deep Learning-Based Model For Automated Prediction Of Coastal Changes: A Robust Approach To Environmental Forecasting, Tsair-Fwu Lee, Chu-Ho Chang, Chin-Shiuh Shieh, Chih-Hsien Wu, Jen-Chung Shao, Chien-Liang Chiu Jan 2025

Deep Learning-Based Model For Automated Prediction Of Coastal Changes: A Robust Approach To Environmental Forecasting, Tsair-Fwu Lee, Chu-Ho Chang, Chin-Shiuh Shieh, Chih-Hsien Wu, Jen-Chung Shao, Chien-Liang Chiu

Journal of Marine Science and Technology–Taiwan

The coastline stands as a critical domain encompassing industry and the environment. The escalating global warming, leading to elevated sea levels and intensified wave-current interactions, has given rise to substantial coastal erosion. This predicament, in conjunction with excessive human development and Taiwan's coastal areas' extreme climatic impact, accentuates the perceptibility of coastal beach alterations. As a result, coastal erosion has emerged as a pressing issue necessitating resolution. Traditional methodologies for assessing coastline changes have conventionally relied on manual measurements. However, owing to the fluctuating distance of coastlines, influenced by tidal patterns, extended measurement processes over several months are susceptible to …


Hydrographic Influences On Seasonal Variations In Zooplankton Communities Of Taiwan Bank (Southern Taiwan Strait), Bor-Shyr Chen, Frank Paolo Jay B. Albarico, Mark Ariel D. Malto, Aiza D. Gabriel, Chiu-Wen Chen, Cheng-Di Dong Jan 2025

Hydrographic Influences On Seasonal Variations In Zooplankton Communities Of Taiwan Bank (Southern Taiwan Strait), Bor-Shyr Chen, Frank Paolo Jay B. Albarico, Mark Ariel D. Malto, Aiza D. Gabriel, Chiu-Wen Chen, Cheng-Di Dong

Journal of Marine Science and Technology–Taiwan

Understanding the factors that control ocean productivity is crucial in fisheries management. Taiwan Bank, located between the Taiwan Strait and the South China Sea, is a highly productive ecosystem due to upwelling events. The total zooplankton community (holozooplankton and merozooplankton), diversity, seasonal changes, and environmental drivers remain unexplored despite its productivity. This study evaluates the seasonal and vertical environmental dynamics in the Taiwan Bank and their impacts on the zooplankton community structure. We collected zooplankton and basic water parameters in March, July, and September 2017 at 5, 25, and 50 meters. We recorded significant seasonal changes in zooplankton composition and …


Model Performance For Predicting Trends And Analyzing The Impacts Of Sea Surface Temperature Changes In The Gulf Of Thailand, Tanatpong Udomchaipitak, Nathaphon Boonnam Jan 2025

Model Performance For Predicting Trends And Analyzing The Impacts Of Sea Surface Temperature Changes In The Gulf Of Thailand, Tanatpong Udomchaipitak, Nathaphon Boonnam

Journal of Marine Science and Technology–Taiwan

This study focuses on assessing and improving the predictive performance of sea surface temperature (SST) in the Gulf of Thailand under unique environmental challenges. Data from the Hybrid Coordinate Ocean Model (HYCOM) were utilized, covering the period from July 1994 to June 2024 at depths ranging from 0 to 30 meters. After cleaning the data using the Interquartile Range (IQR) method, the processed dataset was tested using four models: Recurrent Neural Network (RNN) architectures, including Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), as well as Convolutional Neural Networks (CNNs). Model performance was enhanced by tuning the parameters over …


Multimodal Imaging Of Protein-Based Biomaterials For Delivering Chemo-Agent Cargo For Glioblastoma Treatment In A Murine Model, Orin Mishkit Jan 2025

Multimodal Imaging Of Protein-Based Biomaterials For Delivering Chemo-Agent Cargo For Glioblastoma Treatment In A Murine Model, Orin Mishkit

Dissertations and Theses

Protein-based self-assembling biomaterials, known as Thermo-Responsive Assembled Proteins (TRAP), present meaningful potential as drug delivery carriers. These materials enable the controlled, slow release of poorly soluble chemotherapeutic agents, such as doxorubicin (Dox), while potentially reducing systemic off-target effects. In collaboration with multiple NYU labs, this study evaluated the efficacy of two TRAP variants—TRAP and F-TRAP—as drug delivery carriers in a xenograft mouse model of glioblastoma multiforme (GBM).

The primary objective was to compare the effectiveness of TRAP-loaded Dox (TRAP-DOX) to free Dox in achieving tumor extravasation and accumulation, facilitating sustained drug release. We hypothesized that the leaky vasculature of GBM …


A Study Exploring The Use Of Artificial Ligaments To Enhance The Human-Robot Interface Via Force Distribution Manipulation In Biomimetic Cuff Systems, Adifet Cejovic Jan 2025

A Study Exploring The Use Of Artificial Ligaments To Enhance The Human-Robot Interface Via Force Distribution Manipulation In Biomimetic Cuff Systems, Adifet Cejovic

Dissertations and Theses

Comfort is among the main priorities when designing a wearable assistive device that needs to be used for long sessions. There is a growing need for wearable systems that provide aid to patients with an injured knee. In addition, there has been an effort to incorporate cable-driven designs rather than rigid attachments. This change in design decreases the overall weight of the system and can allow the cable to adapt to a user’s change in gait patterns. This thesis investigates a cuff system centered around the knee and the design of a testing rig. This system incorporates elements from pre-existing …


Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome Jan 2025

Adaptation Of The Biodent For Spherical Microindentation To Determine Elastic Modulus In Small Rodent Bones, Mixame E. Jerome

Dissertations and Theses

Mechanical and material properties of bone are essential for understanding both normal skeletal function and the progression of bone-related diseases. Microindentation has become a widely used method for evaluating tissue mechanical properties of bone, as it samples the contributions of microarchitecture and composition. Microindentation using a standard pointed tip inherently introduces both elastic and plastic deformation into the material. In contrast, indentation with a spherical tip can be operated entirely in the elastic range, providing for a non-damaging test that has significant advantages over sharp indentation techniques. Moreover, a key advantage of using spherical indentation lies in its operation under …


Explorations Of Dna-Single-Walled Carbon Nanotube Interactions To Develop Multiplexed Molecularly Specific Biosensors For Inflammation, Amelia K. Ryan Jan 2025

Explorations Of Dna-Single-Walled Carbon Nanotube Interactions To Develop Multiplexed Molecularly Specific Biosensors For Inflammation, Amelia K. Ryan

Dissertations and Theses

Inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-12 (IL-12) are central regulators of immune signaling and key biomarkers of disease, yet existing assays for their detection remain slow, invasive, and lack multiplexing ability. This dissertation advances the development of single-walled carbon nanotube (SWCNT) optical nanosensors capable of real-time, multiplexed, and molecularly specific cytokine detection through innovative use of single-stranded DNA (ssDNA) interfaces.

First, an IL-6-specific DNA aptamer was employed as both a dispersing agent and recognition probe for SWCNT fluorescence sensing. Sequence modifications, including anchor domains, truncations, and thermally induced refolding, were systematically tested to optimize sensitivity and selectivity. The …


Wearable Disposable Elecetrotherapy, Mohamad Fallahrad Jan 2025

Wearable Disposable Elecetrotherapy, Mohamad Fallahrad

Dissertations and Theses

Non-invasive electrotherapies offer promising treatments for a wide range of conditions such as pain, headaches, depression, addiction, cognitive decline, wound healing, and drug delivery. However, patient compliance remains low due to the high initial cost, cumbersomeness and inconvenience of existing technology compared to pharmaceuticals. Current electrotherapy devices are often bulky and require users to connect disposable electrodes, initiate programs, and manage charging cycles, which hinders widespread adoption.

We address these challenges by designing and validating a novel electrotherapy platform that is single-use, disposable, low-cost, and wearable. Activated automatically upon skin contact, the device delivers a preset dose of controlled electrical …


Characterization Of The Intrinsic Neural Timescale Indices As A Reliable Fingerprint Of Brain Dynamics, Helya Honarpisheh Jan 2025

Characterization Of The Intrinsic Neural Timescale Indices As A Reliable Fingerprint Of Brain Dynamics, Helya Honarpisheh

Dissertations and Theses

Intrinsic neural timescales (INTs) characterize the persistence of neural activity over time and offer insight into the brain’s temporal hierarchy. This thesis evaluates and compares six autocorrelation-based INT metrics—AR(1) Coefficient (Autoregressive Coefficient at 1), First Zero Lag, Lag at ACF = 1/e, Sum of Positive ACFs, ACF at Half Lag, Exponential Decay Constant (τ)— using resting-state fMRI data from 400 cortical regions across a large, lifespan sample (ages 6– 85) from the NKI-Rockland dataset. A discriminability analysis revealed that the AR(1) coefficient provided the highest test-retest reliability and individual specificity across repeated scans, establishing it as the most reliable INT …


Metasurfaces And Their Applications In Photonic Devices, Shuwei Guo Jan 2025

Metasurfaces And Their Applications In Photonic Devices, Shuwei Guo

Dissertations and Theses

Metasurfaces are flat artificial optical elements composed of dielectric and/or metallic nanostructures. They can manipulate light in unprecedented ways by altering amplitude, phase, and polarization at subwavelength scales. The ability of these two-dimensional elements to perform multiple optical functions within compact optical systems—while offering high functionality, small form factors, and easy integration into optoelectronic devices—has sparked significant interest across various fields and industries. These applications span imaging, sensing, nonlinear and quantum optics, optical computing, automotive technology, augmented and virtual reality, and more.

In this dissertation, we explore and design new multifunctional metasurfaces with a focus on manipulating spectral responses. First, …


Multi-Material Adhesive Bonded Joints Under Static And Dynamic Loading, Gizem Derya Demir Jan 2025

Multi-Material Adhesive Bonded Joints Under Static And Dynamic Loading, Gizem Derya Demir

Dissertations and Theses

Adhesively bonded joints present significant potential for reducing structural weight and enhancing performance in modern and future engineering structures. By enabling the elimination or reduction of traditional mechanical fasteners and facilitating the integration of dissimilar materials, adhesives can contribute to more efficient, lightweight designs. However, to fully leverage these benefits—especially in high-performance applications—adhesive materials must exhibit robust behavior under both static and dynamic loading conditions, such as ballistic impact. Despite their promise, the failure mechanisms of adhesives under such high-strain-rate scenarios remain insufficiently understood.

This dissertation investigates the performance of adhesively bonded multi-material joints subjected to static loading and ballistic …


Generation And Characterization Of Human Blood-Brain Barrier Models For Investigating Neuropsychiatric Disorders And Tumor Metastasis, Yunfei Li Jan 2025

Generation And Characterization Of Human Blood-Brain Barrier Models For Investigating Neuropsychiatric Disorders And Tumor Metastasis, Yunfei Li

Dissertations and Theses

The blood–brain barrier (BBB) is important in the normal function of the central nervous system (CNS). An altered BBB has been described in various neuropsychiatric disorders. The brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if integrity of the BBB formed by BMECs is compromised in 22q11.2 deletion syndrome (also called DiGeorge syndrome), which is one of the validated genetic risk factors for schizophrenia, a 2D iBBB (induced BBB) on a Transwell filter was generated from human microvascular endothelial cells (HBMECs) derived from the induced pluripotent stem cells (iPSCs) out of patients with …


Deep Learning Approaches For Predicting Strain Energy In Heterogeneous Materials, Junesh Gautam Jan 2025

Deep Learning Approaches For Predicting Strain Energy In Heterogeneous Materials, Junesh Gautam

Electronic Theses and Dissertations

Finite Element Analysis (FEA) faces computational challenges when analyzing nonlinear and heterogeneous materials. Utilizing the Mechanical MNIST dataset, comprising 60,000 simulated samples of 28x28 pixel domains under large deformation, the study evaluates classical regression methods (Linear Regression, Random Forest, Gradient Boosting) and advanced deep learning architectures (Convolutional Neural Networks (CNN) and Residual Networks (ResNet)). CNN models achieved superior performance, with a Mean Squared Error (MSE) of 4.21 and an R2 value of approximately 0.982, outperforming classical regression models and slightly surpassing ResNet architectures. These deep learning methods automatically learn spatial relationships from pixel-based representations, eliminating the need for manual feature …


Leveraging Deep Learning For The Automated Detection Of Hemophilic Arthropathy In Knee Radiographs, En-Wei Lin, Edzer Wu, Ming-Ching Shen, Shao-Li Han Jan 2025

Leveraging Deep Learning For The Automated Detection Of Hemophilic Arthropathy In Knee Radiographs, En-Wei Lin, Edzer Wu, Ming-Ching Shen, Shao-Li Han

Rehabilitation Practice and Science

Background/Purpose:

Hemophilic arthropathy (HA) is a progressive joint disease caused by recurrent hemarthroses in patients with hemophilia. Early radiographic identification of HA is critical for timely intervention and long-term joint preservation. This study aimed to develop and evaluate deep learning models for automated detection of HA in knee radiographs.

Methods:

A retrospective dataset of 849 knee radiographs (AP and lateral views) was used to train three convolutional neural networks: ResNet-34, DenseNet-121, and EfficientNet-B0. Model performance was assessed using standard classification metrics, including accuracy, precision, recall, F1-score, and AUC. Interpretability was evaluated using Grad-CAM heatmaps.

Results:

DenseNet-121 achieved balanced performance on …


Motion Planning For A Flexible Modular Raft Robot, Chun-Yi She Jan 2025

Motion Planning For A Flexible Modular Raft Robot, Chun-Yi She

Dartmouth College Master’s Theses

This thesis presents a hierarchical motion planning framework for SoftRafts, a modular and deformable aquatic robot capable of performing locomotion and manipulation tasks on water surfaces. SoftRafts consist of soft and rigid components that enable structural reconfiguration, offering adaptability in unstructured aquatic environments.

To address the complexity of planning in high-dimensional, deformable systems, the proposed method uses a bounding-shape abstraction, specifically, enclosing circles and rectangular bounding boxes to simplify motion planning. These enclosures abstract the robot's overall shape, reducing the high-dimensional planning problem into a lower-dimensional problem. A global planner uses a probabilistic roadmap (PRM) to compute a collision-free path …


Design And Deployment Of A Compact Rov For Deep-Sea Research And Exploration, Joshua F. Wood Jan 2025

Design And Deployment Of A Compact Rov For Deep-Sea Research And Exploration, Joshua F. Wood

Open Access Master's Theses

The scientific community has utilized unmanned underwater vehicles for ocean exploration since the mid-twentieth century, resulting in a well-cultivated and ever-changing discipline of ocean technology. The deep-sea environment, specifically, presents unique and harsh criteria due to the increased pressure found at depth and the vehicle components necessary to overcome it. The size and weight of underwater vehicles typically increase as operational depth increases, resulting in physically large systems with high operational costs to accommodate deep-sea research. This project first characterized the effect of length and diameter on carbon fiber pressure housing’s depth tolerance. It then leveraged this data to reduce …


Minimalistic Communication-Based Swarm Slam, Felix B. Koch Jan 2025

Minimalistic Communication-Based Swarm Slam, Felix B. Koch

Open Access Master's Theses

This study presents and validates Range of Communication Swarm SLAM(RCS-SLAM), a novel SLAM approach designed for multi-robot systems using minimal hardware. Unlike traditional methods that rely on range or bearing measurements, RCS-SLAM only uses the identifiers of nearby robots within communication range. In the front-end, each robot constructs an individual pose graph based on its own odometry, while recording communication events with neighboring robots. The key novelty lies in the use of one-hop communication, where robots not only detect nearby peers but also relay received identifiers, effectively acting as transmitters themselves. This mechanism extends the communication graph and enables the …


Develop A Cross-Platform Toolset For In Situ Deep-Sea Coral Propagation, Joe Bevilacqua Jan 2025

Develop A Cross-Platform Toolset For In Situ Deep-Sea Coral Propagation, Joe Bevilacqua

Open Access Master's Theses

Mesophotic and deep-sea gorgonian octocorals in the Gulf of Mexico were significantly damaged following the Deepwater Horizon oil spill, prompting a major federal investment in developing restoration techniques for these fragile, slow-growing communities. Asexual, in-situ coral propagation offers a biologically viable path for restoration at depth. However, current ROV systems are not optimized for the delicate, fine-scale interactions required to perform this process reliably. The objective of this research was to design, prototype, and evaluate a ROV-mountable toolset capable of preparing octocoral fragments for potting in epoxy substrate, with the additional goal of integrating the toolset into URI’s Coral Carousel …


An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre Jan 2025

An Operational Field Study: A Comparison Of Piloting Uncrewed Underwater Vehicles And Uncrewed Aircraft Systems, David Thirtyacre, Joseph Cerreta, Pete Miller, Kimberly Luthi, Jolee Thirtyacre

Publications

and operations, the ability to cross-train personnel in both Uncrewed Underwater Vehicles and Small Uncrewed Aircraft System operations has become a focal point for efficiency and workforce optimization. This study presents a comparative analysis of the operational and human factor considerations involved in piloting mini UUV and sUASs, highlighting the key similarities and differences in control methods, environmental influences, navigation, emergency procedures, and situational awareness. A qualitative experimental field study was conducted between July 2024 and October 2024, involving real-world deployments of both systems in maritime and aerial environments. Findings indicated that while UUV and sUAS operators relied on remote …


New Insights Into Fertilisation With Animal Manure For Annual Double-Cropping Systems In Nitrate-Vulnerable Zones Of Northeastern Spain, Dolores Quilez, Monica Guillen, Marta Valles, Arturo Dauden, Beatriz Moreno-Garcia Jan 2025

New Insights Into Fertilisation With Animal Manure For Annual Double-Cropping Systems In Nitrate-Vulnerable Zones Of Northeastern Spain, Dolores Quilez, Monica Guillen, Marta Valles, Arturo Dauden, Beatriz Moreno-Garcia

Biological and Agricultural Engineering Faculty Publications and Presentations

Maize double-cropping production systems in Mediterranean areas have a great nitrogen extraction capacity and high nitrogen (N) requirements. This study aims to assess whether in these farming systems, animal manure can be applied, using adequate management practices, at levels exceeding the maximum annual amount of livestock manure established in the European Nitrate Directive for vulnerable zones (170 kg N ha-1) without increasing the risk of water nitrate contamination. We compare the risk of nitrate leaching under two fertilisation strategies, one with synthetic fertilisers and the second with a maximised application of pig slurry, exceeding the limits of the EU Nitrate …


Computational Modeling Of The Heat Treatment Of White Oak Bound For Spirit Maturation, Kate E. Mclarney-Popham Jan 2025

Computational Modeling Of The Heat Treatment Of White Oak Bound For Spirit Maturation, Kate E. Mclarney-Popham

Theses and Dissertations--Chemical and Materials Engineering

Maturation of distilled spirits in white oak barrels is a long standing practice known to have great impact on spirit character. Much of this impact can be controlled by the thermal modification of the barrel, since thermal degradation of the wood determines what wood compounds are available to interact with the spirit during maturation. In this work, a computational model for the thermal degradation of wood was developed and, with flavor compound data from literature, was used to investigate the effect of heat treatment on lignin-derived flavor compounds. The computational model in this work accounted for three solid species, three …


Microstructural Characterization Of Complex Metal Alloy Systems With A Focus On Electron Microscopy, Alexandra Allamon Jan 2025

Microstructural Characterization Of Complex Metal Alloy Systems With A Focus On Electron Microscopy, Alexandra Allamon

Theses and Dissertations--Chemical and Materials Engineering

Multi-principal element alloys (MPEAs)/high-entropy alloys (HEAs) are a class of materials that provide novel and superior combinations of properties, with promise for use in challenging application areas that many of the current established materials cannot fit. With a higher number of constituent elements, many of the newly created alloys are compositionally complex in nature, known to contain combinations of relatively soft FCC phases, hard BCC phases, and, in some cases, even harder intermetallic phases. Microstructural study of these new materials is essential to understanding the enhanced properties they may possess, but their complexity can make this study much more challenging …


Ion Hydration In Bulk And Nanoconfined Water: Insights From Machine Learning Force Fields, Zachary D. Baker Jan 2025

Ion Hydration In Bulk And Nanoconfined Water: Insights From Machine Learning Force Fields, Zachary D. Baker

Theses and Dissertations--Chemical and Materials Engineering

Understanding ionic hydration remains a central challenge in physical chemistry and materials science, as the interactions between ions and water molecules govern diverse phenomena ranging from electrolyte transport to selective ion separation. While experimental techniques have provided invaluable insights into solvation energetics and coordination numbers, they often lack atomistic resolution, particularly under nanoscale confinement where direct measurement becomes infeasible. Molecular dynamics (MD) simulations can bridge this gap; however, conventional classical force fields are limited by their simplified, fixed functional forms and empirical parameterization, whereas ab initio molecular dynamics (AIMD) achieves higher accuracy at the expense of severe computational cost and …


Molecular Characterization Of Leptin Gene In Sheep (Ovis Aries), Shahenda M. Hegazy, Mohamed Fouda, Ahmed Ateya, Huda A. El Emam Jan 2025

Molecular Characterization Of Leptin Gene In Sheep (Ovis Aries), Shahenda M. Hegazy, Mohamed Fouda, Ahmed Ateya, Huda A. El Emam

Mansoura Veterinary Medical Journal

INTRODUCTION: Advances in molecular genetic techniques have simplified the process of identifying individual differences at the DNA level. Genetic polymorphisms at candidate genes controlling economic features have recently drawn a lot of scholarly attention due to their potential as a tool for genetic selection and the identification of evolutionary linkages in livestock. OBJECTIVE: This work aimed to detect nucleotide sequence variants in Lep gene as genetic markers for growth and heat tolerance traits in Barki and Abudeleik sheep using PCR-DNA sequencing approach in search of single nucleotide polymorphisms (SNPs). METHODS: 30 female ewes, 15 of each breed (Barki and Aboudeleik) …


Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop Jan 2025

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …


Modeling Synergistic Effects Of Integrin And Tgf-Β Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar Jan 2025

Modeling Synergistic Effects Of Integrin And Tgf-Β Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar

Theses and Dissertations

The induction of Epithelial Mesenchymal Transition (EMT) is initiated by a

number of protiens and growth factors, one of which is the profibrotic cytokine Trans-

forming Growth Factor β (TGF-β). Within the extracellular matrix (ECM), TGF-β

is found in a latent, inactive form bound to proteins such as fibronectin (FN). For

TGF-β to contribute to EMT induction, it has to be extracted from the latent com-

plexes into a soluble form. This soluble, activated TGF-β can then bind to receptors

on the cell membrane, which causes the transduction of signals that begin EMT. Re-

search has shown that the release …


Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada Jan 2025

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO2) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO2-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO2 were evaluated, one was synthesized following a specific route and the …


Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco Jan 2025

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …