Digital Commons Network^™

Multi-Modal Mri For The Pre-Clinical Evaluation Of Hiv-Linked Changes In The Central Nervous System, Gabriel Gauthier

Theses & Dissertations

Though the inception of anti-retroviral therapy (ART) has fundamentally changed the life expectancy of human immunodeficiency virus (HIV) patients, accessibility and outcomes vary enormously along demographic lines. Even for people living with HIV (PLWH) with perfect access and adherence to anti-retroviral drugs (ARVs), modern treatment plans are fundamentally unable to secure complete viral remission for patients. The cause of this perpetual infection is the persistence of viral reservoirs in the central nervous system (CNS), hidden beyond the reach of modern ARVs, leaving patients to deal with lifelong medication side-effects and risks of developing HIV-associated neurodegenerative disorders (HAND). Despite improving outcomes …

A Framework For Establishing An Automated Traffic Violation Detection System In New Assiut City Using Ordinary Cctv Units, Mahmoud Owais, Ali Shehata, Abdou Shaband, Ghada S. Moussa

Mansoura Engineering Journal

Violating traffic rules in transport networks is a genuine concern for operators as it is one of the most important causes of fatal accidents. With the increasing number of residents in the new cities in the Arab Republic of Egypt, and the incompleteness of the transportation system in those cities, including traffic signs, light signals, and control points, the possibility of committing such violations increases. The study aims to propose the framework for establishing an intelligent monitoring system in the new city of Assiut consisting of high-resolution cameras optimally distributed on the traffic network points in the city. They will …

Direct Computations Of Spatially Resolved Viscoelastic Moduli Of Biomolecular Condensates, Liwen Gu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Biomolecular condensates are viscoelastic materials formed by liquid-liquid phase separations (LLPS) of biopolymers. In this study, we develop a modified graph Laplacian-based collective model to characterize viscoelastic heterogeneity within condensates based on results of lattice-based Metropolis Monte Carlo (MMC) simulations. By integrating random graph models and simulations of A1-LCD, a type of intrinsically disordered protein, we examine how network topology influences storage modulus, loss modulus, crossover frequency, and relaxation time spectra. Our results reveal a strong correlation between topological features and mechanical response, with the condensate interior exhibiting higher stiffness and faster relaxation than the interface. The relaxation spectra provide …

Feasibility Analysis For The Implementation Of An Anaerobic Digestion System In The City Of Pittsburgh, Pa, Gianna L. Kolencik

Electronic Theses and Dissertations

The current study is investigating the feasibility of an anaerobic digestion system

in Pittsburgh, Pennsylvania, at the old State Correctional Institute (SCI-Pittsburgh)

located at 1922 Westhall St. This location is immediately upstream of the Allegheny

County Sanitary Authority (ALCOSAN) along the Ohio River. Municipal solid waste

from ALCOSAN may be used as the main form of feedstock. ALCOSAN produced

roughly 36,500 tons of dry sludge in the reporting year 2023-2024. Based on the volume

of dry sludge from ALCOSAN it is estimated that an anaerobic digestion system could

yield approximately 29,930,000 kWh of energy, which is enough to power over …

Production Of Sustainable Liquid Fuel From Waste Polymeric Materials Via Thermal Pyrolysis, Md. Sabbir Ahmed, Selim Reja, Sk Md Ali Zaker Shawon, Farhana Nazmin, Abdullah Mohammad Sarjish, Yousuf Ali, M. Azizur R. Khan, M. Jasim Uddin, Md. Wasikur Rahman

Mechanical Engineering Faculty Publications

The widespread use of polymeric materials has become an environmental threat as they are durable and nonbiodegradable in nature, which is directly responsible for severe ecological consequences. Thermal pyrolysis offers a sustainable and efficient approach to converting these polymeric waste materials into liquid fuel, which is also referred to as pyrolysis oil (PO). In this study, a novel method was developed for producing oil from a composite of waste polymers that include vehicle tires, tubes, and medical waste. A fixed-bed stainless steel reactor is used to thermally breakdown the waste polymeric feedstock (300–750°C) in an inert environment. The PO was …

American Football Internal Helmet Padding Material And Design Testing, Spencer J. Pigman

Honors Thesis

Football helmets have evolved significantly to improve player safety and reduce the risk of concussions and traumatic brain injuries. Early leather designs offered minimal protection, while modern helmets use advanced materials to absorb and distribute impact forces more effectively. To support ongoing helmet safety research, a custom 3D-printed headform modeled from a human scan was equipped with a WitMotion BWT901BLECL5.0 accelerometer and used in controlled drop tests. The study evaluated various internal padding materials including spray foam, two sizes of bubble wrap, Oobleck, scrub sponges, KTOESHEO foam, Hijelyn air pillows, and the standard padding from a Riddell Victor youth helmet. …

Alterations And Improvements Of The Photoacoustic Flow Cytometry Method, Nicholas J. Taylor

Electronic Theses and Dissertations

The emergence and proliferation of antibiotic-resistant bacteria present a significant and growing challenge to global public health, with the potential to render many existing antibiotics ineffective. Infections caused by these resistant pathogens are difficult to treat, resulting in higher morbidity, mortality, and healthcare costs. A major obstacle in combating these infections is the slow pace of traditional diagnostic methods, such as blood cultures, which typically take 2-3 days to identify the causative bacteria and determine their antibiotic resistance profiles. This delay in diagnosis hinders timely interventions and appropriate treatment, further contributing to the spread of resistant infections. As such, there …

The Effects Of Flood Irrigation Vs. Pivot Irrigation On Groundwater Recharge, Tea Rainey

Graduate Theses & Non-Theses

Groundwater can be an important resource for river flow support, and this is especially true with the Big Hole River in southwestern Montana which is mainly fed by groundwater late in the summer season. Maintaining the source of groundwater is an important focus both for the Big Hole River Watershed Committee as well as local ranchers. Agriculture uses large quantities of water, and as technology advances many ranchers are turning to the use of pivot lines for irrigation. Historically, flood irrigation was used when surface water was available. Surface water sources include tributary streams as well as diversions from the …

Snowmelt Runoff Driven Hydropower Modelling Based On Spaceborne Remotely Sensed And Ground Weather Network Data, Ninad Bhagwat

Graduate Theses & Non-Theses

Identification of new optimal hydropower locations provides an opportunity to improve mankind's green energy portfolio by developing new hydroelectric plants, thereby decreasing the carbon footprint. Preliminary analysis of locating the optimal hydropower sites is generally the first step towards construction of a new hydropower plant. In this dissertation, I developed a parsimonious, yet robust tool to perform the preliminary analysis to locate optimal hydropower locations in any watershed using the remotely sensed Digital Elevation Model (DEM). Simulating the snowmelt-derived streamflow is crucial for water resources management in snow-dominated watersheds. The Snowmelt Runoff Model (SRM) is a lumped-parameter, temperature-index model that …

Peroxi-Electrocoagulation For Pfas Mitigation: The Impact Of Water Quality And Dissolved Organic Matter On Removal Pathways, Donald R. Ryan, Claire K. Baldus, Shimaa M. Kteeba, Melvin Samuel, Yin Wang, Laodong Wang, Brooke K. Mayer, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

The recent addition of per- and polyfluoroalkyl substances (PFAS) to the National Primary Drinking Water Regulation per- has increased the need for research on PFAS treatment technologies for water and wastewater. Electrochemical treatment processes have been widely investigated for PFAS removal. Peroxi-electrocoagulation (electrocoagulation paired with hydrogen peroxide (EC:H₂O₂)) was evaluated as a novel water treatment process for PFAS mitigation due to the multimechanistic removal pathways that can proceed during treatment, including chemical degradation via oxidation, and physical separation pathways such as sorption to flocs, flotation layer accumulation, and foam fractionation. This work investigated the impacts of …

The Role Of Piezo1 In Mediating Chondrocyte Cell Signaling And Senescence, Sophie Gretler Paradi

McKelvey School of Engineering Graduate Student Theses & Dissertations

Osteoarthritis (OA), the leading cause of disability, is driven by articular cartilage degeneration and inflammation. Mechanosensitive ion channels PIEZO1 and PIEZO2 have been implicated in OA progression via calcium signaling in chondrocytes. This study investigates the role of conditional Piezo channel knockout (cKO) in modulating calcium signaling and senescence in OA, particularly under the supra-physiologic inflammatory condition of a high-fat diet (HFD). Using calcium imaging, we found that Piezo1 cKO and dual Piezo1/2 cKO significantly reduced Yoda1-induced calcium signaling, while Piezo2 cKO alone had no effect. Under HFD conditions, Piezo1 cKO showed a non-significant trend toward reduced calcium influx, potentially …

Towards The Performance Characterization Of A Robotic Multimodal Diagnostic Imaging System, George Papaioannou, Christos Mitrogiannis, Mark Schweitzer, Nikolaos Michailidis, Maria Pappa, Pegah Khosravi, Apostolos Karantanas, Sean Starling, Christian Ruberg

Publications and Research

Characterizing imaging performance requires a multidisciplinary approach that evaluates various interconnected parameters, including dosage optimization and dynamic accuracy. Radiation dose and dynamic accuracy are challenged by patient motion that results in poor image quality. These challenges are more prevalent in the brain/cardiac pediatric patient imaging, as they relate to excess radiation dose that may be associated with various complications. Scanning vulnerable pediatric patients ought to eliminate anesthesia due to critical risks associated in some cases with intracranial hemorrhages, brain strokes, and congenital heart disease. Some pediatric imaging, however, requires prolonged scanning under anesthesia. It can often be a laborious, suboptimal …

Functional Devices Based On Freestanding 2d Materials, Shijue Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Two-dimensional (2D) materials have attracted extensive attention in the field of nanoelectronics due to their atomic-scale thickness, high surface-to-volume ratio, tunable electronic properties, and compatibility with low-temperature processing. These characteristics make them highly suitable for the construction of emerging device architectures, particularly in both ionic and electronic devices.

In this work, we investigate the application of 2D materials in two distinct classes of devices: ionically-driven memristors and electronically-dominated metal–semiconductor contacts. For the memristor study, we fabricate heterostructure-based resistive switching devices using h-BN and WSe₂ as active layers. These 2D material-based memristors exhibit stable power consumption loops and high linearity …

Soft, Adhesive Dry Electrodes For Improved Electrophysiological Signal Acquisition With Motion Tolerance And Long-Term-Recoverability, Ryan Andersen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Soft electronic devices and sensors have seen substantial interest devoted to them for the purpose of recording and analyzing various electrophysiological signals including for the use of electrocardiography (ECG), electromyography (EMG), and electroencephalography (EEG). Dry electrodes specifically have enormous potential compared to traditional commercial electrodes for long-term, real-time monitoring of biopotential activity. Gel-based commercial electrodes have notable drawbacks such as limited flexibility, skin irritation that decreases comfort, inconsistent signal quality due to poor conformal contact, and degraded signal quality over long-term monitoring due to drying out.

Herein, we report a soft, adhesive dry electrode that utilizes chemical additives to promote …

Facilitating Design Of Effective, Scalable Digital Mental Health Care, Himanshu Mahesh Patil

Dartmouth College Master’s Theses

This thesis tackles the challenges of designing effective, scalable digital mental health care solutions by integrating psychological research with human-computer interaction (HCI) principles. An exploration of self-care technologies (SCTs) for mental health is conducted to highlight challenges to comparative analysis, like fragmented research outcomes. Two research questions are posed to investigate how mental health interventions can be designed to be effective and overcome practical challenges to implementation. A theoretical framework in clinical psychology is adapted to bridge the gap between psychology and HCI. A methodology for conducting standardized, structured comparative analysis of mental health interventions is identified. The identified method …

Partially Supervised Reinforcement Learning For Gps-Denied Navigation, Ethan Weilheimer

McKelvey School of Engineering Graduate Student Theses & Dissertations

Navigating dynamic environments is a key challenge for autonomous agents, yet most existing research focuses on 3D settings or settings where the agent has full access to relevant semantics. In this work, we propose a learning framework for aerial navigation in the presence of changing dynamics and limited positional information. Specifically, we consider a drone navigation task where a drone at one time has access to GPS location information, which it has now lost and needs to navigate in the same area but at a future time with no GPS signal and differing transition dynamics. To address this, we introduce …

Adaptive Noise Estimation And Denoising With Deep Learning For Nmr Spectroscopy, Naveen Asokan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique widely used for molecular structure elucidation in chemistry, biology, and medicine. However, spectral accuracy is often degraded by noise—particularly in low acquisition time settings—resulting in reduced resolution and obscured chemical features. While traditional noise reduction techniques such as signal averaging can improve spectral quality, they require longer acquisition times, limiting their utility in real-time and high-throughput applications.

This thesis presents a deep learning-based denoising framework designed to enhance the quality of complex-valued NMR spectra. The proposed model, built upon a U-Net architecture, incorporates both real and imaginary components of the …

Preliminary Study: Minimizing The Gap Between Pre-And Post-Spaceflight, Caleb E. Scheideger, Louis A. Diberardino

Aurora

Long-duration space missions pose significant challenges to astronaut health, primarily due to the detrimental effects of microgravity on musculoskeletal and cardiovascular systems. This research proposal aims to address the critical gap between pre- and post-spaceflight physiological conditions, focusing on the marked decline in muscle mass, bone density, and cardiovascular function. Existing countermeasures, such as resistive exercise, are insufficient to prevent muscle atrophy and bone demineralization, highlighting the need for novel solutions. Neuromuscular Electrical Stimulation (NMES) emerges as a promising intervention, capable of eliciting muscle contractions to maintain function and mitigate atrophy. By integrating NMES into existing exercise regimens, we hypothesize …

Gradient Fibro-Porous Materials For Tailored Sound Absorption, William Johnston, Janith Godakawela, Bhisham Sharma

Michigan Tech Publications

Reducing the pore size of bulk sound absorbers often increases weight and introduces manufacturing challenges, limiting their practical use. To address these issues, a class of materials is introduced that uses 3D printing to seamlessly integrate fibers within porous scaffolds, allowing improved sound absorption performance without a significant weight addition. The reliance on 3D printing enables the creation of gradient fibro-porous structures with customizable acoustic properties. This study explores the effect of through-thickness gradients in the scaffold’s relative density, fiber thickness, and fiber density on the acoustical performance with the goal of identifying the optimal strategy to obtain broader and …

Biogenic Synthesis Of Metallic And Bimetallic Oxide Nanoparticles For Water Treatment Applications, Gunarani G.I

Theses and Dissertations

Access to clean water is a quality-of-life indicator. The availability of clean water apart from water scarcity is marred due to contamination by heavy metals and synthetic dyes, posing a grave environmental and public health challenge. This necessitates the implementation of advanced and sustainable treatment solutions towards water remediation. This research work focusses on the fabrication and application of biogenic and chemically synthesized metallic and bimetallic nanoparticles for the efficient removal of uranium, chromium, and toxic dyes from aqueous environments. The study particularly focuses on zero-valent (C-Fe and B-Fe) and bimetallic (C-NiFe and B-NiFe) nanoparticles, evaluating their adsorption capabilities and …

Solar Sailing Adaptive Control Around The Earth-Moon Lagrange Point L4 For Stellar Observations, Luis Mendoza Zambrano

Doctoral Dissertations and Master's Theses

To expand our knowledge about the influence of the Sun in the cislunar region, as well as our understanding of shocks due to Coronal Mass Ejections and large coronal magnetic reconnection, a solar sailing approach is proposed to separately capture lunar occultations and observe the solar corona from L₄ of the Earth-Moon system. Single and multiple shooting techniques are described along with a pseudo arc-length continuation method for preliminary orbit design. Periodic orbits in the vicinity of L₄ are obtained in the context of the Earth-Moon circular restricted three-body problem (CR3BP) and the Sun-Earth-Moon bi-circular restricted four-body problem …

Soft Modular Robots: From Modular Tensegrity Structures To Bioinspired Sea Robots, Luyang Zhao

Dartmouth College Ph.D Dissertations

The rapid advancement of robotics necessitates systems capable of adapting to complex, unstructured environments. Soft robots, with their flexibility and compliance, excel in delicate interactions, making them ideal for medical applications and search-and-rescue missions. Modular robots, on the other hand, offer reconfigurability, enabling diverse task-specific adaptations in dynamic settings. Despite their individual advantages, the integration of soft and modular robotics remains underexplored. This proposal aims to develop soft modular robots that combine the adaptability of soft robotics with the versatility of modularity. These systems will be capable of autonomously transitioning between locomotion, manipulation, and infrastructure assembly across land, water, and …

Predicting Sorption Of Diverse Organic Compounds In Soil-Water Systems: Meta-Analysis, Machine Learning Modeling, And Global Soil Mapping, Jiachun Sun, Kai Zhang, Huichun Zhang

Faculty Scholarship

In recent decades, the environmental detection of various organic compounds (OCs) has highlighted the limitations of conventional soil-water sorption models, which simplify complex experimental conditions and often overlook OCs with polyfunctional and ionizable structures. To address these shortcomings, we compiled a comprehensive soil-water sorption dataset encompassing 20,945 data points for 419 OCs with various functional groups and 1037 different soils. Meta-analysis of the dataset revealed the trends of soil sorption associated with OC substructures, soil properties, and solution conditions. Machine learning models employing the XGBoost algorithm, in conjunction with MACCS fingerprints and experimental conditions, were developed to cover the entire …

Fundus Retinal Images And Glaucoma Detection, Lama Alsabban, Malak Alnahdi, Nema Salem

Effat Undergraduate Research Journal

Abstract. Glaucoma is a severe eye disease that has no symptoms and, globally, it is the second cause of blindness. Glaucoma causes structural changes in the retina that make ophthalmologists detecting the disease in early stage and thus provide the suitable treatment. Fundus camera is an imaging technique that provides the fundus image showing the internal structure of retina. Our project provides an automated system for early detection of Glaucoma. The proposed system based MATLAB starts by acquiring the fundus image, followed by preprocessing stage, going through noise removal, enhancement, segmentation, feature extraction and ends up by the classification stage. …

A Hybrid Technique For Approximating The Solution Of Fractional Order Partial Integro-Differential Equations, Ahmed K. Mohsin, Fajir A. Abdulkhaleq, Osama H. Mohammed

Iraqi Journal for Computer Science and Mathematics

In this paper, we discuss the numerical solution of fractional order partial integro-differential equations. The type of fractional derivative used is a Caputo derivative. The method proposed in this paper known as transform optimal perturbation iteration method. This method combines the optimal perturbation iteration method and the Laplace transform in order to converge to the exact solution. The proposed method is highly efficient and provides the means of controlling the approximate solutions convergence. Illustrative examples prove that the suggested approach is very accurate when compared with the exact solution and the results of the existing methods.

The Effect Of Boom Leveling On Spray Dispersion, Miguel Bustamante, Juan F. Vivanco, Travis A. Burgers

Mechanical Engineering Faculty Publications

Automatic boom height systems reduce the variability of agricultural sprayer boom height. When a boom is not at its target height, this can lead to uneven spray dispersion from the nozzles. Boom heights and sprayer position were previously measured in time for three commercially-available boom leveling systems for three test runs for at least three speeds over each of a mild, medium and rough terrain course. A computational model was created to use measured spray dispersion from a nozzle, measured boom heights in time, and measured sprayer position in time to calculate a spray coverage map. The model was used …

Autonomous Agricultural Equipment Evaluation For Broad-Acre Crop Production, Sofia Bahmutsky, Ashutosh Singh, Travis A. Burgers, Roy Maki

Mechanical Engineering Faculty Publications

No abstract provided.

Dna Storage Of Images: From Pixels To Molecules, Cihan Ruan

Engineering Ph.D. Theses

DNA storage is rapidly emerging as a transformative solution for long-term, ultra-dense, and energy-efficient archival systems. This dissertation builds upon a deep understanding of image compression principles to design encoding frameworks that are uniquely attuned to the biochemical constraints of DNA storage. By fusing insights from traditional coding with molecular-level design, we develop a series of technically advanced solutions tailored for this emerging medium.

Our first contribution introduces Dynamic DNA-Fountain, a constrained codec that maps H.266 /VVC-compressed bitstreams to quaternary DNA sequences, optimizing for both information density and biochemical synthesis constraints. Building upon this foundation, we shift focus toward robustness—leveraging …

Intercellular Stress Generation During 1d Collective Migration Of Cancer Cells, Logan Waddle

Physics Undergraduate Honors Theses

Physical forces drive many cellular processes such as migration and proliferation. A metastatic tumor will have invasive strands/chains that extend from the main tumor. These chains of cells collectively migrate away from the main tumor to establish new colonies elsewhere in the body. However, how physical forces drive this collective invasion and the required energy for this process is not well understood. Invasion of a metastatic tumor to surrounding tissues leads to a majority of cancer-associated death and is often a collective effort among cells, it is therefore important to fully understand the process behind collective cancer invasion.

The goal …

Toxicity And Biodegradability Of Novel Boronium Vs Conventional Ammonium Based Anti Microbial Compounds In Wastewater Treatment Systems, Noor Shalan

Poster Presentations

Quaternary ammonium compounds (QACs) are highly effective as disinfectants, herbicides, and pesticides; thus, overuse causes elevated levels of residual toxicity in domestic and industrial wastewater. QACs can be toxic to essential bacteria breaking down pollutants in wastewater treatment plants (WWTPs) and can remain untreated in effluent, harming the environment, and contributing to antibiotic resistance, posing risks to human health. Novel boronium-based antimicrobial compounds have demonstrated efficacy in eliminating bacteria, fungi, and viruses. If the boronium compounds exhibit lower residual toxicity, they could offer a promising alternative to QACs. Because these compounds are still in development, their potential toxicity to the …