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Effects Of Herbicides On 2,4-D-Resistant Soil Microorganisms In Maize Cultivation In Lopburi Province, Thailand, Boontarik Chimchart, Jitra Kokaew, Amnat Eamvijarn, Kanokon Bunpha, Sontaya Khamtib, Monchai Manassila, Tawatchai Inboonchuay Jan 2025

Effects Of Herbicides On 2,4-D-Resistant Soil Microorganisms In Maize Cultivation In Lopburi Province, Thailand, Boontarik Chimchart, Jitra Kokaew, Amnat Eamvijarn, Kanokon Bunpha, Sontaya Khamtib, Monchai Manassila, Tawatchai Inboonchuay

Applied Environmental Research

This study aimed to assess the impact of herbicide application on soil micro-organism density and to identify microorganisms resistant to 2,4-D-dimethyl-ammonium (2,4-D) for potential biodegradation. Research was conducted in maize plots in Lopburi Province, where 2,4-D was applied at a rate of 120 g of active ingredient per 160 m2. The soil samples were collected at various intervals: before application; 2 and 4 hours postapplication; and 1, 3, and 7 days after application. The analyses included soil property and microorganism population analyses. The results indicated that 2,4-D applications significantly increased bacteria and fungi in the treated plots compared with those …


Précis Of The Edge Of Sentience: Risk And Precaution In Humans, Other Animals, And Ai, Jonathan Birch Jan 2025

Précis Of The Edge Of Sentience: Risk And Precaution In Humans, Other Animals, And Ai, Jonathan Birch

Animal Sentience

We often face grave practical decisions that seem to hinge on whether a system is sentient. This family of cases includes invertebrate animals, people who are unresponsive after brain injury, fetuses, neural organoids, and now AI technologies. We must decide what to do despite ongoing disagreement about the nature of sentience. In our state of uncertainty, we should pragmatically transform the question from “Is it sentient?” to “Is it a sentience candidate, an investigation priority, or neither?”. When a system is a sentience candidate, it is negligent to fail to consider precautions. We should instead evaluate precautions for their proportionality …


Manure Handling In Circular Farming: An In Vitro Study Of Fermented Poultry Manure As Unconventional Feed For Ruminants, Dimas Hand Vidya Paradhipta, De Lavida Padma Terrakota, Ali Agus, Andriyani Astuti, Viagian Pastawan, Kharisma Taufiqa Hidayah Jan 2025

Manure Handling In Circular Farming: An In Vitro Study Of Fermented Poultry Manure As Unconventional Feed For Ruminants, Dimas Hand Vidya Paradhipta, De Lavida Padma Terrakota, Ali Agus, Andriyani Astuti, Viagian Pastawan, Kharisma Taufiqa Hidayah

ASEAN Journal on Science and Technology for Development

The development of the poultry industry must consider the principle of circular economy. Therefore, this study aims to develop a method of fermenting poultry manure as a new, unconventional feed, which can support the model of circular farming. Poultry manure obtained from laying hens was mixed with cassava solid waste at a ratio of 7:3 to maintain proper moisture content. The mixed manure fermented for 14 days into a 30 kg silo in triplicate using different additives, namely Lactiplantibacillus plantarum FNCC 0020 at 1 x 105 cfu/g (LP), Bacillus cereus LS2B as proteolytic bacteria at 1 x …


Bagasse Lignin For Single-Used Food Packaging Applications: Uv-Barrier, Antioxidant, Migration And Cytotoxicity, Pawarisa Wijaranakul, Bongkot Hararak, Wanwitoo Wanmoolee, Prapudsorn Wannid, Weerawan Laosiripojana Jan 2025

Bagasse Lignin For Single-Used Food Packaging Applications: Uv-Barrier, Antioxidant, Migration And Cytotoxicity, Pawarisa Wijaranakul, Bongkot Hararak, Wanwitoo Wanmoolee, Prapudsorn Wannid, Weerawan Laosiripojana

Journal of Metals, Materials and Minerals

This study examined PLA biocomposite films made from organosolv lignin extracted from Thai agro-waste, specifically sugarcane bagasse (BG), to assess their suitability for food packaging, focusing on their physical, thermal, optical, UV-shielding, antioxidant, and migration properties. Extracted BG-lignin exhibited free radical scavenging ability with an EC50 value of 400 µg/ml, reducing DPPH absorbance by 50%. PLA composite films with BG-lignin dosage from 0.1 to 1.0 wt.% were successfully fabricated via conventional blown film extrusion. Addition of BG-lignin at 0.5 wt.% and 1.0 wt.% to PLA films decreased UV transmittance from 90% to 30% and 12%, respectively, without compromising optical clarity. …


Biological Computing From Microscopic To Macroscopic Evolution, Xiaofeng Ding Jan 2025

Biological Computing From Microscopic To Macroscopic Evolution, Xiaofeng Ding

Masters Theses

A unified theory from microscopic to macroscopic DNA-based biological systems is explained in terms of the rule components used when the system size is increased. Even though the eight female rules in each ruleset are provided with an equal probability of the computation-state outcomes, the initial ensemble of the computation states will exponentially settle into one dominant rule that supports the nutrition needed for growth. The remaining seven rules form into two minority groups to provide the biological characteristics of the system's growth from a micro to macroscopic evolution. The object of this study is to prove that such a …


Microwave-Assisted Reduction Of Critical Metal Oxides From E-Waste Mixture, Kurundu Shavinka Jayasekera Jan 2025

Microwave-Assisted Reduction Of Critical Metal Oxides From E-Waste Mixture, Kurundu Shavinka Jayasekera

Graduate Theses, Dissertations, and Problem Reports (ETD)

The efficient recovery of critical metals such as tantalum (Ta), manganese (Mn), gallium (Ga), and indium (In) from electronic waste (e-waste) is essential for resource sustainability and environmental protection. This research uses microwave-assisted treatment to investigate the carbothermal reduction of these four specific metals from their oxides in a simulated e-waste mixture, with carbon black serving as both a microwave coupling and reduction agent. Microwave processing is used specifically because it offers a rapid and energy-efficient alternative to conventional thermal methods, with the benefits of intrinsic heating and selective heating of materials. The first experiments centered on understanding the effects …


Enhanced Optimization Of Mass Transfer For Carbon Capture And Wastewater Remediation In Algal Systems Through Algorithmic And Bioprocessing Techniques, Peter Ofuje Obidi Jan 2025

Enhanced Optimization Of Mass Transfer For Carbon Capture And Wastewater Remediation In Algal Systems Through Algorithmic And Bioprocessing Techniques, Peter Ofuje Obidi

Doctoral Dissertations

The scalability and industrial deployment of algal cultivation systems are limited by suboptimal mass transfer, constraining their effectiveness in carbon capture and wastewater remediation. This research investigated these challenges through integrated optimization methodologies that combine algorithmic frameworks with enhanced bioprocessing techniques to enhance efficiency, economy, and scalability. A System-of-Systems (SoS) meta-architecture was developed using genetic algorithms and fuzzy assessor functions to demonstrate a pathway toward cost reduction. Rigorous mechanical and chemical characterizations were quantitatively analyzed to reveal existing optimization strategies and further evaluated the best strategies to use in enhancing mass transfer for improved biomass yield. The work also integrates …


Nutrient Fate, Mass Balance, Species Selection, And Plant Management Strategies With Floating Treatment Wetlands, Carla Campbell Jan 2025

Nutrient Fate, Mass Balance, Species Selection, And Plant Management Strategies With Floating Treatment Wetlands, Carla Campbell

Doctoral Dissertations

Excess nutrients in shallow urban ponds can lead to harmful algal blooms, low dissolved oxygen, and internal phosphorus cycling. These effects can compromise municipal water supplies and cause negative impacts on fisheries and recreation. Floating treatment wetlands (FTWs) show promise to mitigate surface water nutrient pollution. However, despite recent research, many aspects of FTWs remain poorly characterized. The contribution of FTW components to nutrient removal, local species selection, and plant management strategies were the focus of this dissertation. Mesocosm experiments revealed that the combination of plants and coir fiber growth media in FTWs appeared to positively affect plant biomass gain …


Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar Jan 2025

Green Chelation Strategy For Deashing Of Algal Biomass, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

This study investigated a green chelation strategy for deashing algal biomass using nitrilotriacetic acid (NTA) and deionized water (DI) to enhance its suitability for biofuel and bioproduct applications. Solid-state algal turf scrubber (SS ATS), green algal turf scrubber (ATS), and Scenedesmus were analyzed, with Scenedesmus selected for detailed evaluation due to its high ash removal efficiency. The objective was to optimize a purification process that minimizes ash and heavy metal content while preserving biochemical integrity. Algal biomass underwent sequential washing with DI, NTA, and NTA+DI under varying temperatures (90-130 °C). Analytical techniques including Fourier Transform Infrared (FTIR) spectroscopy, Inductively Coupled …


Biochar For Soil Amendment: Applications, Benefits, And Environmental Impacts, Ujjwal Pokharel, Gururaj Neelgund, Ram L. Ray, Venkatesh Balan, Sandeep Kumar Jan 2025

Biochar For Soil Amendment: Applications, Benefits, And Environmental Impacts, Ujjwal Pokharel, Gururaj Neelgund, Ram L. Ray, Venkatesh Balan, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

The excessive use of chemical fertilizers results in environmental issues, including loss of soil fertility, eutrophication, increased soil acidity, alterations in soil characteristics, and disrupted plant–microbe symbiosis. Here, we synthesize recent studies available from up to 2025, focusing on engineered biochar and its application in addressing issues of soil nutrient imbalance, soil pollution from inorganic and organic pollutants, soil acidification, salinity, and greenhouse gas emissions from fields. Application of engineered biochar enhanced the removal of Cr (VI), Cd²+, Ni²+, Zn²+, Hg²+, and Eu³+ by 85%, 73%, 57.2%, 12.7%, 99.3%, and 99.2%, …


Quantifying Inositol Phosphate Dephosphorylation To Understand The Role Of Recalcitrant Organic Phosphorus Forms On Harmful Algal Blooms In Freshwater Systems, Iffat Tasnim Jan 2025

Quantifying Inositol Phosphate Dephosphorylation To Understand The Role Of Recalcitrant Organic Phosphorus Forms On Harmful Algal Blooms In Freshwater Systems, Iffat Tasnim

College of Graduate Studies: Theses & Dissertations

Organophosphorus such as phytic acid, a surrogate species of inositol phosphate (IP), may serve as a source for orthophosphate (OP) in freshwater. In absence of OP, competent aquatic microorganisms upregulate the production of specialized enzymes to obtain growth-sustaining OP from organic phosphorus (org-P) forms. The contribution of recalcitrant org-P to the OP pool has been overlooked due to the lack of capable tools to measure OP production from org-P accurately. The objective of this study was to quantify OP production from phytic acid (a surrogate form of recalcitrant org-P) to assess the contribution of recalcitrant org-P forms to the total …


Development And Characterization Of Sustainable Coal–Biomass Briquettes Of Sub-Bituminous Coal And Levistona Chinensis Biomass, Amad Ullah Khan, Borhen Louhichi, Muhammad Abas, Muhammad Saleem, Nashmi H. Alrasheedi, Farida Anjum, Aamer Sharif Jan 2025

Development And Characterization Of Sustainable Coal–Biomass Briquettes Of Sub-Bituminous Coal And Levistona Chinensis Biomass, Amad Ullah Khan, Borhen Louhichi, Muhammad Abas, Muhammad Saleem, Nashmi H. Alrasheedi, Farida Anjum, Aamer Sharif

Research outputs 2022 to 2026

The increasing demand for sustainable energy solutions has driven the exploration of alternative fuels, such as coal–biomass briquettes, which combine the benefits of both coal and renewable biomass sources. This study focuses on the development and characterization of sustainable coal–biomass briquettes made from sub-bituminous coal (SubC) and Levistona chinensis seed biomass, with the aim of reducing environmental impact and enhancing combustion properties. Briquettes were produced by varying the coal-to-biomass ratios (90:0–0:90), with 10% corn starch used as a binder. Proximate analysis revealed that increasing biomass content raised moisture (5.85%–14.25%) and volatile matter (VM; 24.75%–32.5%), while reducing ash (15.75%–3.39%) and fixed …


Energy Saving Technology For Drying Garlic (Allium Sativum), Jasur Esirgapovich Safarov, Shakhnoza Abduvaxitovna Sultanova, А M. Mirkomilov Dec 2024

Energy Saving Technology For Drying Garlic (Allium Sativum), Jasur Esirgapovich Safarov, Shakhnoza Abduvaxitovna Sultanova, А M. Mirkomilov

Technical science and innovation

Food drying is a widely used preservation method aimed at reducing water content to extend shelf life, decrease weight, and enhance storage efficiency. This process, particularly in garlic, involves rapid initial moisture loss followed by a slower phase due to the increasing difficulty of extracting residual water. Drying methods include natural solar drying and advanced mechanical techniques such as hot air and vacuum drying, each influencing product quality, drying efficiency, and economic feasibility. Dehydrated garlic exhibits specific sensory, physico-chemical, and microbiological characteristics, making it suitable for various applications, including powder production. Advanced drying equipment optimizes air volume, temperature, and material …


Enhancing Concrete Sustainability With Self-Healing Technologies, Al Shimaa Abdullatif Dec 2024

Enhancing Concrete Sustainability With Self-Healing Technologies, Al Shimaa Abdullatif

Theses and Dissertations

Thanks to its strength, durability and affordability, Portland cement concrete is the most commonly used building material worldwide. However, concrete cracking is inevitable due to numerous factors including shrinkage, exposure to external chemicals, internals reactions, excessive loads, to name but a few. Self-healing is a promising technique that can enable concrete to autogenously heal cracks and alleviate much of the damage. Such healing can without a doubt extend the service life with less need for external repair works therefore it contributes to sustainability. Over the years, several means of self-healing agents have been explored including bio-based procedures and the incorporation …


Local Food System Planning On Multiple Governance Scales: A Grounded Theory Analysis, Decker Ure Dec 2024

Local Food System Planning On Multiple Governance Scales: A Grounded Theory Analysis, Decker Ure

Theses and Dissertations

Local food systems (LFS) comprise the people, policies, infrastructure and practices of food production, distribution, and consumption in localized areas. LFS are becoming an increasingly important part of urban sustainable development and have recently gained significant traction in the urban planning and sustainable community spheres. Worldwide shocks to global food systems such as the COVID-19 pandemic and the Ukraine-Russia war have further elevated global interest in LFS, bringing local food to the forefront of many communities as they try to insulate themselves and their food supply from future risk. However, despite this growing interest in and policy momentum for local …


Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla Dec 2024

Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla

Biomedical Engineering ETDs

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality.

Previous studies have shown that mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating bacterial infections remains unclear.

Here, we found that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also …


Integrating Image Data Fusion And Resnet Method For Accurate Fish Freshness Classification, Yahya Layth Khaleel, Mustafa Abdulfattah Habeeb, Ghadeer Ghazi Shayea Dec 2024

Integrating Image Data Fusion And Resnet Method For Accurate Fish Freshness Classification, Yahya Layth Khaleel, Mustafa Abdulfattah Habeeb, Ghadeer Ghazi Shayea

Iraqi Journal for Computer Science and Mathematics

Fish freshness classification is critical for protecting public health and ensuring efficient economic, regulatory and environmental sustainability. Classifying accurately reduces the risk of foodborne illness, protects product quality, builds consumer trust and supports sustainable resource conservation through waste minimization. However, the traditional methods for determining fish freshness are variable, time consuming and subjective, precluding practical use. This research presents an improved framework that integrates image data fusion and a deep learning ResNet model to differentiate fresh and nonfresh fish. From multiple sources, a comprehensive dataset including 16,640 samples was curated, and data fusion was used to increase the diversity and …


Utilizing Pupper, A Social Robot Dog, To Increase Happiness And Improve Mood In Pediatric Patients Of A Cardiac Step-Down Unit, Angela Feng Wu Dec 2024

Utilizing Pupper, A Social Robot Dog, To Increase Happiness And Improve Mood In Pediatric Patients Of A Cardiac Step-Down Unit, Angela Feng Wu

Master's Projects and Capstones

Objective The usage of social robots in pediatrics is an emerging field of study. Preliminary research shows that they are effective at improving the psychosocial well-being of pediatric patients. This quality improvement project focuses on Pupper, a newly developed quadruped social robot dog, and its ability in improving mood and happiness in pediatric patients of a cardiac step-down unit. Aim The aim of this project is to increase average mood scores of pediatric cardiac patients aged 3-25 years by 50% from their baseline of 3.75 to 5.63 on a six-point scale within a one-month time frame. Methods Before intervention and …


Jovial Family Farm Facilitates Intergenerational Learning Opportunities Through Urban Farming, Maera Williams Dec 2024

Jovial Family Farm Facilitates Intergenerational Learning Opportunities Through Urban Farming, Maera Williams

Purdue Journal of Service-Learning and International Engagement

Maera Williams is a sophomore in Environmental and Ecological Engineering at Purdue University. She joined the Engineering Projects in Community Service (EPICS) Urban Farming team as a freshman and now serves as project manager of ten undergraduate students collaborating with Jovial Family Farm to design and develop three indoor hydroponics systems for a laboratory space on their property in Broad Ripple, IN. Jovial Family Farm is a nonprofit organization founded by Drs. Bobbie and Brian Jellison with the mission to provide senior citizens, their families, and their communities with meaningful engagement opportunities on an intergenerational scale through urban agricultural activities. …


Yield Comparison Of Three Melon (Cucumis Melo L.) Varieties Cultivated With Dutch Bucket And Drip Irrigation Systems, Widiya Puji Kumalasari, Suwarto, Etik Wukir Tini, Endang Warih Minarni Dec 2024

Yield Comparison Of Three Melon (Cucumis Melo L.) Varieties Cultivated With Dutch Bucket And Drip Irrigation Systems, Widiya Puji Kumalasari, Suwarto, Etik Wukir Tini, Endang Warih Minarni

Jurnal Kultivasi

Melon is one of the horticultural commodities with considerable economic potential. Cultivation through hydroponic systems can provide efficiency and increase production if complemented by superior varieties. This study aims to identify the best hydroponic system and melon variety combination with the highest yield. The research was conducted from November 2023 to April 2024 at the screen house in Pasir Kulon Village, Karanglewas District, Banyumas Regency, at 110 m above sea level. The study used a split-plot factorial design with a basic design of a Completely Randomized Block Design. The first factor was the hydroponic system, consisting of S1 = Dutch …


Enhancement Of Ambient Air Quality Index Forecasting Using Optimized Ensemble Model, Vanitha M Dec 2024

Enhancement Of Ambient Air Quality Index Forecasting Using Optimized Ensemble Model, Vanitha M

Theses and Dissertations

Forecasting ambient air quality is essential for environmental sustainability and public health, especially in heavily populated regions such as China, India, and the United States where air pollution remains a serious concern. Traditional forecasting models often struggle to accurately represent air quality data because of its complex patterns and nonlinear interactions. To address these challenges and improve forecast performance, this research proposes a comprehensive strategy that integrates parallel heterogeneous ensemble modeling with Bayesian optimization.

The study begins with a seasonal machine learning–based imputation technique (SeasonalMLImpute) designed to handle missing data in meteorological and air quality parameters. This method is evaluated …


Agronomic Biofortification Of Calcium In Pak Choy (Brassica Rapa Subsp. Chinensis) Via Hydroponic Nutrient Film Technique, Regina Septiani Zahro, Khavid Faozi, Zulfa Ulinnuha, Agus Sarjito Dec 2024

Agronomic Biofortification Of Calcium In Pak Choy (Brassica Rapa Subsp. Chinensis) Via Hydroponic Nutrient Film Technique, Regina Septiani Zahro, Khavid Faozi, Zulfa Ulinnuha, Agus Sarjito

Jurnal Kultivasi

Pak choy is rich in calcium, magnesium, phosphorus, iron, and vitamin K, all essential for health. Pak choy requires a proper balance of nutrients for optimal growth. In a hydroponic system, any imbalance in nutrient levels can negatively impact plant growth and reduce the nutritional value stored in the tissues. Selecting suitable varieties and providing appropriate calcium treatment can help increase calcium content and enhance productivity. This study aims to determine the effect of calcium concentration on growth, yield, and Ca content and the most responsive varieties to increased calcium concentration. The research design used was a Split Plot Design …


Nasa Microgreen Cultivation In Space Utilizing Pegda Hydrogels, Thomas Alarcon Ali, Zohaib Gabriel Khan, Ariel Marroquin, Samuel Martinez, Fabiha Samiha, Emily Yong Dec 2024

Nasa Microgreen Cultivation In Space Utilizing Pegda Hydrogels, Thomas Alarcon Ali, Zohaib Gabriel Khan, Ariel Marroquin, Samuel Martinez, Fabiha Samiha, Emily Yong

Publications and Research

During long-term space expeditions, it is crucial that astronauts receive the nutrients they need to maintain their overall health. While the current space diet of palatable foods is commendable and constantly evolving, nutritional content and food quality degrades over long durations. Microgreens are excellent candidates for space cultivation because they are nutrient-dense, young plants that are are densely grown and harvested when leaves are just emerging. However, antigravity, microgreen fragility, degradation speed, contamination, and limited water resources are substantial barriers to doing so. This study aims to address these challenges by cultivating microgreens inside a hydrogel, a soilless medium, to …


Impact Of Irrigation Systems On Water Use And Water Productivity: A Case Study Using Aquacrop In Khartoum, Sudan, Abdalhakam Almagzoop Dec 2024

Impact Of Irrigation Systems On Water Use And Water Productivity: A Case Study Using Aquacrop In Khartoum, Sudan, Abdalhakam Almagzoop

Department of Agricultural and Biological Systems Engineering: Masters Project Reports

Water scarcity significantly challenges agricultural productivity in arid regions like Khartoum, Sudan. This study evaluates the impact of three irrigation systems—furrow, sprinkler, and surface drip—on the water use and productivity of sorghum (Sorghum bicolor L.) under different climatic conditions using the AquaCrop model. Simulations were conducted for three representative years: a wet year (2022), a normal year (2015), and a dry year (2018). The results demonstrate that irrigation substantially improved water use efficiency and crop yield compared to non-irrigated (rainfed) conditions. Rainfed crops resulted in lower biomass, harvest index, and yield, particularly in the dry year, highlighting the importance …


Rehydration Kinetics Of Green Pea Grains Dried At Different Microwave Powers, Serap Kayisoglu Dec 2024

Rehydration Kinetics Of Green Pea Grains Dried At Different Microwave Powers, Serap Kayisoglu

The Philippine Agricultural Scientist

In this study, both untreated and pre-treated green pea grain samples dried at different microwave output powers (90, 180, and 360 W) were rehydrated at three different temperatures (30ºC, 50ºC, and 70ºC). The rehydration kinetics of dried peas were analyzed using both the Peleg and the first-order kinetic models. Observations revealed that the Peleg model exhibited better agreement with the experimental data. As both microwave power and rehydration temperature increased, the rehydration capacity also increased in both pre-treated and untreated peas. The highest moisture content was observed after rehydration in pre-treated peas dried at 360 W microwave power (2.80 g …


Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain Dec 2024

Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain

Graduate Theses and Dissertations

Food safety and sustainability are critical concerns in the food industry. However, these areas are often evaluated separately, leading to an incomplete understanding of the overall impact of food production on human health. This dissertation aims to integrate food safety with sustainability to provide a comprehensive assessment of the impact of low-moisture foods on human health, using the almond processing supply chain as a case study.

In addition to conducting life cycle assessments (LCA) of almond processing, wheat flour production, and dried apple processing, this dissertation aims to create a framework to bridge the gap between sustainability and food safety. …


Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster Dec 2024

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …


Assessing General Propulsion Architectures For Fast Transit Times To Mars For Crewed Missions, Vivek Bhatt Dec 2024

Assessing General Propulsion Architectures For Fast Transit Times To Mars For Crewed Missions, Vivek Bhatt

Doctoral Dissertations and Master's Theses

As NASA and commercial contractors, such as SpaceX, continue to develop their programs with Artemis and Starship, respectively, it is becoming more and more apparent that the program developments are ultimately for finding a way to put humans onto Mars. However, when we approach the current timeline of going to Mars, it usually involves a 6-9 month one way trip. Due to this, human spaceflight to Mars becomes more dangerous as exposure to affects such as solar radiation, long exposure to low gravity fields, and isolation. These are some of the many hazards that come with interplanetary space travel for …


Biological Reduction Of Mixed Oxyanions In Wastewater Brine, Katherine J. Earp Dec 2024

Biological Reduction Of Mixed Oxyanions In Wastewater Brine, Katherine J. Earp

UNLV Theses, Dissertations, Professional Papers, and Capstones

Treatment of contaminated brine water is an area of active research spurred by the use of advanced treatment technologies, such as membrane separation, reverse osmosis, ion exchange, etc. for water reuse and recycling, which has become critical due to the impact of climate change on water resources throughout the globe. Biological reduction of harmful organic and inorganic pollutants in water has been demonstrated as an effective method for water and wastewater treatment and would be a potential technology for brine treatment. However, biodegradation of contaminants in high salinity waters is challenging because most microbial communities cannot survive brine environments. The …


Understanding Failure Mechanisms For Two Colorectal Anastomosis Techniques, Youssef Sherif Sadek Fahmy Dec 2024

Understanding Failure Mechanisms For Two Colorectal Anastomosis Techniques, Youssef Sherif Sadek Fahmy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Colorectal Surgery continues to be one of the most common gastrointestinal surgeries performed in the US. A common complication known as Anastomotic Leakage (AL) that threatens up to 30% of patients with this surgery. Many cases of AL can decrease the quality of life for patients or extensively extend hospital stays, and in many cases, lead to death. Researchers have studied this complication in clinical trials, yet few studied the mechanics of stapled anastomosis in controlled environments. The purpose of this research was to understand the mechanical interaction between the staples and the tissue, and to eventually apply it in …