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Proceedings, Msvscc 2011, Old Dominion University, Department Of Modeling, Simulation & Visualization Engineering, Old Dominion University, Virginia Modeling, Analysis & Simulation Center Apr 2011

Proceedings, Msvscc 2011, Old Dominion University, Department Of Modeling, Simulation & Visualization Engineering, Old Dominion University, Virginia Modeling, Analysis & Simulation Center

Modeling, Simulation and Visualization Student Capstone Conference

Proceedings of the 5th Annual Modeling, Simulation & Visualization Student Capstone Conference held on April 14, 2011 at VMASC in Suffolk, Virginia. 186 pp.


Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 8, 2011, Wright State University Office Of Undergraduate Research And Stemm Activities Apr 2011

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 8, 2011, Wright State University Office Of Undergraduate Research And Stemm Activities

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 8, 2011.


48th Conference On Senior Engineering Design, College Of Engineering And Applied Sciences Apr 2011

48th Conference On Senior Engineering Design, College Of Engineering And Applied Sciences

Senior Engineering Design Conference

The 48th Conference on Senior Engineering Design Projects was held on April 19, 2011 at the College of Engineering and applied Sciences on the Parkview Campus of Western Michigan University. The college sponsors the conference to showcase the work of its graduating seniors, who are required to complete a capstone project that puts into practice what they have learned. Many of the projects are sponsored by business and industry.


The Effect Of Maternal Diet On Fetal Development, Catherine Wilcox Apr 2011

The Effect Of Maternal Diet On Fetal Development, Catherine Wilcox

Renée Crown University Honors Thesis Projects - All

Using mice as a model system, this study aimed to compare the effect of a high fat diet (HFD), high sugar diet (HSD) and a control diet (CD) on fetal growth and development at the time of birth (post-natal day 0 or PND 0), post-natal day 7 (PND 7) and post-natal day 14 (PND 14). Published literature has documented the effects of a negative in-utero environment on fetal development, but currently there is limited research regarding the continued effects on development after birth. Mouse pups were harvested and then imaged in 3-D using a high-resolution micro-computed tomography (micro-CT) system. Total …


The Solvent Effectiveness On Extraction Process Of Seaweed Pigment, Warkoyo Warkoyo, Elfi Anis Saati Apr 2011

The Solvent Effectiveness On Extraction Process Of Seaweed Pigment, Warkoyo Warkoyo, Elfi Anis Saati

Makara Journal of Technology

Eucheuma cottonii seaweed is a species of seaweed cultured in Indonesian waters, because its cultivation is relatively easy and inexpensive. It has a wide variety of colors from green to yellow green, gray, red and brown, indicating photosynthetic pigments, such as chlorophyll and carotenoids. An important factor in the effectiveness of pigment extraction is the choice of solvent. The correct type of solvent in the extraction method of specific natural materials is important so that a pigment with optimum quality that is also benefical to the society can be produced. The target of this research is to obtain a high …


Characterization And In Vitro Toxicity Of Copper Nanoparticles (Cu-Nps) In Murine Neuroblastoma (N2a) Cells, Sitao Veronica Brownheim Mar 2011

Characterization And In Vitro Toxicity Of Copper Nanoparticles (Cu-Nps) In Murine Neuroblastoma (N2a) Cells, Sitao Veronica Brownheim

Theses and Dissertations

Nanomaterials, classified as materials within the 1 - 100 nanometer range, have seemingly endless applications. It is very important to the Air Force to increase the understanding of Cu-NPs and the possible health impacts from nanomaterial exposure prior to wide-spread industry and military use. Therefore, the purpose of this research is to thoroughly characterize the properties of three different copper samples upon suspension into aqueous solutions over time: Cu-NPs (Cu 25 nm), CuO-NPs (CuO 40 nm), and Cu-MSP (Cu 500nm). Additionally, this research seeks to observe in vitro effects upon murine neuroblastoma cells (N2A) by these three types of particles …


Optimization Of Point-Of-Use Water Treatment Device For Disaster Relief, Margaret June Herzog Mar 2011

Optimization Of Point-Of-Use Water Treatment Device For Disaster Relief, Margaret June Herzog

Master's Theses

Point-of-use (POU) drinking water treatment is a common method of providing drinking water in disaster relief situations when critical water infrastructure is damaged. In these cases, POU treatment devices can be used to treat local water until relief organizations set up more permanent water provision methods. One such POU technology is PŪR® Purifier of Water, a combined coagulation/flocculation and disinfection chemical treatment sachet produced by Procter & Gamble. PŪR® has been shown to treat contaminated water to meet water quality standards and guidelines set by the U.S. EPA for water purifiers and by the World Health Organization and …


Hardy Diagnostics Facility Redesign, Jamie W. Lam Mar 2011

Hardy Diagnostics Facility Redesign, Jamie W. Lam

Industrial and Manufacturing Engineering

This senior project is a facilities design for the plate production room at Hardy Diagnostics. This project was completed using a systematic layout planning approach. The main reason for this redesign was to consolidate all plate line production into one room. This would ensure better visability for the managers. After the project was defined, the different departments were established and the relationships between those departments were found. The space requirements needed for those departments were then measured out to also include the aisle widths and any machinery or carts needed to complete each function. Having determined all requirements for this …


Method Of Improving Cheese Quality, Colm D. Everard, Donal J. O'Callaghan, Colm P. O'Donnell, Colleen C. Fagan, Manuel Castillo, Frederick Alan Payne Feb 2011

Method Of Improving Cheese Quality, Colm D. Everard, Donal J. O'Callaghan, Colm P. O'Donnell, Colleen C. Fagan, Manuel Castillo, Frederick Alan Payne

Biosystems and Agricultural Engineering Faculty Patents

A method is provided for improving the quality of cheese produced from a curd and whey mixture. The method comprises the steps of monitoring the curd and whey mixture during syneresis processing to collect color data, comparing the color data to a predetermined standard and terminating syneresis when the color meets the predetermined standard or, alternatively, analyzing the color data obtained to generate kinetic parameters that can be used to predict the end point of syneresis to improve control of curd moisture content.


Development Of A Centrifugal Microfluidic Device For Separation And Sorting In Biological Fluids, Gaurav Sunil Bagwe Jan 2011

Development Of A Centrifugal Microfluidic Device For Separation And Sorting In Biological Fluids, Gaurav Sunil Bagwe

Theses

A wide interest in employing micron-scale, integrated biochemical analysis systems for economical and rapid diagnosis has been the principal motivation behind this project. Low operating costs, portability and fast diagnosis times make centrifugal microfluidic devices an attractive option in patient-side diagnostics. Some essential tasks to be performed in microfluidic devices are sample-reagent transport, mixing, separation and detection. All these tasks require precise control of the RPM and spinning time. Centrifugal micro-fluidic platforms have been successfully implemented for detection of hepatitis A, tetanus, as well as for measurement of haemoglobin and hematocrit, for DNA analysis, and for assessment of cardiac disease …


Study Of Water Use And Supply In The District Of Independencia, Peru, Fletcher A. Mckenzie Jan 2011

Study Of Water Use And Supply In The District Of Independencia, Peru, Fletcher A. Mckenzie

Dissertations, Master's Theses and Master's Reports - Open

Peru is a developing country with abundant fresh water resources, yet the lack of infrastructure leaves much of the population without access to safe water for domestic uses. The author of this report was a Peace Corps Volunteer in the sector of water & sanitation in the district of Independencia, Ica, Peru. Independencia is located in the arid coastal region of the country, receiving on average 15 mm of rain annually. The water source for this district comes from the Pisco River, originating in the Andean highlands and outflowing into the Pacific Ocean near the town of Pisco, Peru.

The …


Eating Rate During A Fixed-Portion Meal Does Not Affect Postprandial Appetite And Gut Peptides Or Energy Intake During A Subsequent Meal, J. Phillip Karl, Andrew J. Young, Scott J. Montain Jan 2011

Eating Rate During A Fixed-Portion Meal Does Not Affect Postprandial Appetite And Gut Peptides Or Energy Intake During A Subsequent Meal, J. Phillip Karl, Andrew J. Young, Scott J. Montain

United States Army: Publications

Eating rate has recently been shown to influence energy intake and appetite during an ad libitummeal, and alter postprandial secretion of glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) following a fixed-portionmeal. Whether these effects influence satiety, as measured by energy intake at the subsequent meal, is unclear. We manipulated eating rate during a fixed-portion meal in order to examine how eating behavior and associated periprandial and postprandial responses of putative endocrine mediators of appetite would affect energy intake at the following meal in fifteen non-obese (BMI ≥ 25 kg/m²) and ten obese (BMI ≥ 30 kg/m²) healthy adult men and …


Bedside Method To Estimate Actual Body Weight In The Emergency Department, Robert G. Buckley, Christine R. Stehman, Frank L. Dos Santos, Robert H. Riggenburgh, Aaron Swenson, Nathan Mjos, Matt Brewer, Sheila Mulligan Jan 2011

Bedside Method To Estimate Actual Body Weight In The Emergency Department, Robert G. Buckley, Christine R. Stehman, Frank L. Dos Santos, Robert H. Riggenburgh, Aaron Swenson, Nathan Mjos, Matt Brewer, Sheila Mulligan

United States Navy: Publications

Background:

Actual body weight (ABW) is important for accurate drug dosing in emergency settings. Oftentimes, patients are unable to stand to be weighed accurately or clearly state their most recent weight.

Objective:

Develop a bedside method to estimate ABW using simple anthropometric measurements.

Methods:

Prospective, blinded, cross-sectional convenience sampling of adult Emergency Department (ED) patients. A multiple linear regression equation from Derivation Phase (n = 208: 121 males, 87 females) found abdominal and thigh circumferences (AC and TC) had the best fit and an inter-rater correlation of 0.99 and 0.96, respectively: Male ABW (kg) = -47.8 + 0.78 * (AC) …


Algea Suspension Dewatering With An Inclined Gravity Settler, Jing Hou Jan 2011

Algea Suspension Dewatering With An Inclined Gravity Settler, Jing Hou

ETD Archive

Biofuel has been studied for several decades as a feasible substitute for petroleum, which may solve the energy crisis. Having a high oil content and growth rate, algae biofuels have received lots of attention recently, and have been considered as one of the most promising technologies to reduce the dependence of fossil fuels. In the process of producing algae biofuel, the dewatering process constitutes a significant part of the cost of the algae biofuel, impeding progress towards large-scale commercial use. An inclined settler utilizes gravity to separate algae cells from the fluid, with little energy consumption. The separation ability of …


Determination Of Threshold Adverse Effect Doses Of Percutaneous Vx Exposure In African Green Monkeys, Raymond F. Genovese, Bernard J. Benton, John L. Oubre, Christopher E. Byers, E. Michael Jakubowski, Robert J. Mioduszewski, Timothy J. Settle, Thomas J. Steinbach Jan 2011

Determination Of Threshold Adverse Effect Doses Of Percutaneous Vx Exposure In African Green Monkeys, Raymond F. Genovese, Bernard J. Benton, John L. Oubre, Christopher E. Byers, E. Michael Jakubowski, Robert J. Mioduszewski, Timothy J. Settle, Thomas J. Steinbach

United States Army: Publications

Percutaneous exposure to the chemical warfare nerve agent VX was evaluated in African green monkeys (n = 9). Doses of VX (7.5–100 μg/kg) were applied to the skin for 60 min and residual agent was quantified (before decontamination) to estimate the absorbed dose. Monkeys were evaluated for the presence or absence of clinical signs of toxicity and blood was sampled periodically (30 min–12 weeks) following exposure to measure the degree of circulating acetylcholinesterase (AChE) inhibition. Monkeys were also evaluated for behavioral changes fromVXexposure using a serial probe recognition (SPR) task. The lowest observable adverse effect level (LOAEL) for the production …


Complete Genome Sequence Of Lactobacillus Buchneri Nrrl B-30929, A Novel Strain From A Commercial Ethanol Plant, Siqing Liu, Timothy D. Leathers, Alex Copeland, Olga Chertkov, Lynne Goodwin, David A. Mills Jan 2011

Complete Genome Sequence Of Lactobacillus Buchneri Nrrl B-30929, A Novel Strain From A Commercial Ethanol Plant, Siqing Liu, Timothy D. Leathers, Alex Copeland, Olga Chertkov, Lynne Goodwin, David A. Mills

United States Department of Energy: Publications

Lactobacillus buchneri strain NRRL B-30929 was a contaminant obtained from a commercial ethanol fermentation. This facultative anaerobe is unique because of its rapid growth on xylose and simultaneous fermentation of xylose and glucose. The strain utilizes a broad range of carbohydrate substrates and possesses a high tolerance to ethanol and other stresses, making it an attractive candidate for bioconversion of biomass substrates to various bioproducts. The genome sequence of NRRL B-30929 will provide insight into the unique properties of this lactic acid bacterium.


Modification Of Native Grasses For Biofuel Production May Increase Virus Susceptibility, Abbie C. Schrotenboer, Michael S. Allen, Carolyn M. Malmstrom Jan 2011

Modification Of Native Grasses For Biofuel Production May Increase Virus Susceptibility, Abbie C. Schrotenboer, Michael S. Allen, Carolyn M. Malmstrom

United States Department of Energy: Publications

Bioenergy production is driving modifications to native plant species for use as novel biofuel crops. Key aims are to increase crop growth rates and to enhance conversion efficiency by reducing biomass recalcitrance to digestion. However, selection for these biofuel-valuable traits has potential to compromise plant defenses and alter interactions with pests and pathogens. Insect-vectored plant viruses are of particular concern because perennial crops have potential to serve as virus reservoirs that influence regional disease dynamics. In this study, we examined relationships between growth rates and biomass recalcitrance in five switchgrass (Panicum virgatum) populations, ranging from near wild type …


Ecosystem Services Altered By Human Changes In The Nitrogen Cycle: A New Perspective For Us Decision Making, Jana E. Compton, John A. Harrison, Robin L. Dennis, Tara L. Greaver, Brian H. Hill, Stephen J. Jordan, Henry Walker, Holly V. Campbell Jan 2011

Ecosystem Services Altered By Human Changes In The Nitrogen Cycle: A New Perspective For Us Decision Making, Jana E. Compton, John A. Harrison, Robin L. Dennis, Tara L. Greaver, Brian H. Hill, Stephen J. Jordan, Henry Walker, Holly V. Campbell

United States Environmental Protection Agency: Publications

Human alteration of the nitrogen (N) cycle has produced benefits for health and well-being, but excess N has altered many ecosystems and degraded air and water quality. US regulations mandate protection of the environment in terms that directly connect to ecosystem services. Here, we review the science quantifying effects of N on key ecosystem services, and compare the costs of N-related impacts or mitigation using the metric of cost per unit of N. Damage costs to the provision of clean air, reflected by impaired human respiratory health, are well characterized and fairly high (e.g. costs of ozone and particulate damages …


Maternal Influences On Epigenetic Programming Of The Developing Hypothalamic-Pituitary-Adrenal Axis, Curtis E. Grace, Sung-Je Kim, John M. Rogers Jan 2011

Maternal Influences On Epigenetic Programming Of The Developing Hypothalamic-Pituitary-Adrenal Axis, Curtis E. Grace, Sung-Je Kim, John M. Rogers

United States Environmental Protection Agency: Publications

Parental and environmental factors during the prenatal and postnatal periods permanently affect the physiology and metabolism of offspring, potentially increasing disease risk later in life. Underlying mechanisms are being elucidated, and effects on a number of organs and metabolic pathways are likely involved. In this review, we consider effects on the developing hypothalamic-pituitary-adrenal (HPA) axis, which may represent a common pathway for developmental programming. The focus is on prenatal and early postnatal development, during which the HPA axis may be programmed in a manner that affects health for a lifetime. Programming of the HPA axis involves, at least in part, …


Current And Future Needs For Developmental Toxicity Testing, Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl Jan 2011

Current And Future Needs For Developmental Toxicity Testing, Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari, Rochelle Tyl

United States Environmental Protection Agency: Publications

A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening of pharmaceuticals and chemicals, for evaluating and labeling of pharmaceuticals, and for characterizing hazards and risk of exposures to industrial and environmental chemicals. The in vivo study designs utilized in hazard characterization and dose-response assessment for developmental outcomes have not changed substantially over the past 30 years and have …


Aryl Hydrocarbon Receptor Activation During Pregnancy, And In Adult Nulliparous Mice, Delays The Subsequent Development Of Dmba-Induced Mammary Tumors, Tao Wang, Heather M. Gavin, Volker M. Arlt, B. Paige Lawrence, Suzanne E. Fenton, Daniel Medina, Beth A. Vorderstrasse Jan 2011

Aryl Hydrocarbon Receptor Activation During Pregnancy, And In Adult Nulliparous Mice, Delays The Subsequent Development Of Dmba-Induced Mammary Tumors, Tao Wang, Heather M. Gavin, Volker M. Arlt, B. Paige Lawrence, Suzanne E. Fenton, Daniel Medina, Beth A. Vorderstrasse

United States Environmental Protection Agency: Publications

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the prototypic ligand for the aryl hydrocarbon receptor (AhR), promotes tumor formation in some model systems. However, with regard to breast cancer, epidemiological and animal studies are inconclusive as to whether exposure increases tumor incidence or may instead be protective. We have previously reported that mice exposed to TCDD during pregnancy have impaired differentiation of mammary tissue, including decreased branching and poor development of lobuloalveolar structures. Because normal pregnancy-induced mammary differentiation may protect against subsequent neoplastic transformation, we hypothesized that TCDD-treated mice would be more susceptible to chemical carcinogenesis after parturition. To test this, mice were …


Effects Of Nitrogen Deposition And Empirical Nitrogen Critical Loads For Ecoregions Of The United States, Linda H. Pardo, Mike E. Fenn, Christine L. Goodale, Linda. H. Geiser, Charles T. Driscoll, Edith B. Allen, Jill S. Baron, Roland Bobbink, Williams D. Bowman, Christopher M. Clark, Bridget Emmett, Frank S. Gilliam, Tara L. Greaver, Sharon J. Hall, Erik A. Lilleskov, Lingli Liu, Jason A. Lynch, Knute J. Nadelhoffer, Steven S. Perakis, Molly J. Robin-Abbott, John L. Stoddard, Kathleen C. Weathers, Robin L. Dennis Jan 2011

Effects Of Nitrogen Deposition And Empirical Nitrogen Critical Loads For Ecoregions Of The United States, Linda H. Pardo, Mike E. Fenn, Christine L. Goodale, Linda. H. Geiser, Charles T. Driscoll, Edith B. Allen, Jill S. Baron, Roland Bobbink, Williams D. Bowman, Christopher M. Clark, Bridget Emmett, Frank S. Gilliam, Tara L. Greaver, Sharon J. Hall, Erik A. Lilleskov, Lingli Liu, Jason A. Lynch, Knute J. Nadelhoffer, Steven S. Perakis, Molly J. Robin-Abbott, John L. Stoddard, Kathleen C. Weathers, Robin L. Dennis

Civil and Environmental Engineering - All Scholarship

Human activity in the last century has led to a significant increase in nitrogen (N) emissions and atmospheric deposition. This N deposition has reached a level that has caused or is likely to cause alterations to the structure and function of many ecosystems across the United States. One approach for quantifying the deposition of pollution that would be harmful to ecosystems is the determination of critical loads. A critical load is defined as the input of a pollutant below which no detrimental ecological effects occur over the long-term according to present knowledge.

The objectives of this project were to synthesize …


A Secure Behavior Modification Sensor System For Physical Activity Improvement, Alan Price Jan 2011

A Secure Behavior Modification Sensor System For Physical Activity Improvement, Alan Price

CGU Theses & Dissertations

Today, advances in wireless sensor networks are making it possible to capture large amounts of information about a person and their interaction within their home environment. However, what is missing is how to ensure the security of the collected data and its use to alter human behavior for positive benefit.

In this research, exploration was conducted involving the "infrastructure" and "intelligence" aspects of a wireless sensor network through a Behavior Modification Sensor System. First was to understand how a secure wireless sensor network could be established through the symmetric distribution of keys (the securing of the infrastructure), and it involves …


A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown Jan 2011

A Model To Integrate Sustainability Into The User-Centered Design Process, Adrienne Shevonne Brown

Electronic Theses and Dissertations

With concerns for the environment becoming more prevalent in business and the government, it is increasingly important to re-evaluate and update processes to include sustainability considerations early in the design process. In response to this charge, this research effort was designed to integrate sustainability factors into the usercentered design process. The results of this research highlight the benefits of sustainability requirement planning, as well as those derived from integrating sustainability into the current user-centered design model


Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar Jan 2011

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.


Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar Jan 2011

Eastern Michigan University Undergraduate Catalog, 2011-2012, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.


Eastern Ichigan University Graduate Catalog, 2011-2012, Office Of The Registrar Jan 2011

Eastern Ichigan University Graduate Catalog, 2011-2012, Office Of The Registrar

Graduate Catalogs

No abstract provided.


Nutrient Removal From Urban Stormwater Using Floating Treatment Wetland System, Md Kamrul Islam Jan 2011

Nutrient Removal From Urban Stormwater Using Floating Treatment Wetland System, Md Kamrul Islam

Electronic Theses and Dissertations

Despite the technology advancement, degradation of water quality due to stormwater continues to be a significant threat to the water and ecosystems due to the exponential growth of industries and agricultural enterprises that discharge stormwater. These anthropogenic activities are the sources of high nitrogen and phosphorus quantities in stormwater, which is responsible for eutrophication phenomena and deterioration of public health. Floating Treatment Wetlands (FTWs) are a potential solution to this problem. Both microcosm and mesocosm level studies were conducted for the effective removal of nutrients in stormwater wet detention ponds with different sorption media under varying nutrient concentrations and weather …


A Fuzzy Rule-Based System For Predicting The Live Weight Of Holstein Cows Whose Body Dimensions Were Determined By Image Analysis, Şaki̇r Taşdemi̇r, Abdullah Ürkmez, Şeref İnal Jan 2011

A Fuzzy Rule-Based System For Predicting The Live Weight Of Holstein Cows Whose Body Dimensions Were Determined By Image Analysis, Şaki̇r Taşdemi̇r, Abdullah Ürkmez, Şeref İnal

Turkish Journal of Electrical Engineering and Computer Sciences

The aim of this study was to determine the body measurement of Holstein cows through image analysis (IA) and to estimate their live weight (LW) by means of a fuzzy rule-based model using the body measurements. For this purpose, a photography environment was established at a dairy cattle farm where a large number of cows were kept. First, digital photographs of each animal were synchronously taken from different directions with Canon EOS 400D cameras. At the same time, body dimensions, namely wither height (WH), hip height (HH), body length (BL), and hip width (HW), of the cows were manually measured …


Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins Jan 2011

Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins

United States Army: Publications

Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on  military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) functions in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). We developed a fathead minnow brain-tissue cDNA library enriched for transcripts differentially expressed in response to RDX and …