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Formulation Of Nanoparticle Systems For Drug Delivery Application In Biomedical Sciences, Victor Alfredo Rodriguez

Open Access Theses & Dissertations

Antibiotic-resistant strains of bacteria may result in serious infections which are difficult to treat. In addition, the poor antibiotic pipeline has also contributed to the crisis. Recently, the complex of furosemide and silver (Ag-FSE) has been reported as a potential antibacterial agent. However, its poor aqueous solubility is limiting its activity as an effective antibacterial agent. The purpose of this study was to encapsulate Ag-FSE into chitosan nanoparticles (CSNPs) and evaluate antibacterial efficacy. Ag-FSE CSNPs were prepared using ionic gelation technique. The particle size, polydispersity index and zeta potential of Ag-FSE CSNPs were determined using dynamic light scattering (DLS) technique. …

Acclimatization And Application Of Biofilters For Nitrogen Removal In Marine Recirculating Shrimp Culture System, Penpicha Satanwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research involved in the complete nitrogen removal in marine recirculating aquaculture system (RAS) through sequential nitrification and denitrification processes using internal biofilter within a single tank. The study was divided into two experimental parts. The first study was to estimate the effects of salinity (5, 15 and 25 PSU) and stocking density (50 and 100 shrimp m-2) on nitrification and denitrification efficiencies, as well as on microbial diversity in the biofilm. Also, the nitrogen removal efficiencies of fibrous BiocordTM biofilter and Japanese filter mat were compared. Results showed that the nitrification was stimulated in low-salinity (5 PSU) system with …

Green Composites Of Polylactic Acid Filled With Natural Fiber For Biodegradation Application, Chamaiporn Yamoum

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research focuses on how to use natural fibers available from agricultural residues to produce biodegradable materials such as mulch films. Green composites were prepared from natural fibers (peanut shell and bagasse fiber) and polylactic acid (PLA) together with plasticizers. The presence of plasticizers improved PLA molecular mobility as seen by the reduction of glass transition, cold crystallization, and melting temperatures. The addition of natural fibers into PLA brought down decomposition temperature when compared to PLA. The morphological study of the composites showed poor interfacial adhesion between natural fibers and PLA matrix. Moreover, the loading of plasticizers improved distribution of …

Engineering Surface Properties To Modulate Inflammation And Stem Cell Recruitment Through Macrophage Activation, Kelly M. Hotchkiss

Theses and Dissertations

Biomaterials are becoming the most commonly used therapeutic method for treatment of lost or damaged tissue in the body. Metallic materials are chosen for high strength orthopaedic and dental applications. Titanium (Ti) implants are highly successful in young, healthy patients with the ability to fully integrate to surrounding tissue. However the main population requiring these corrective treatments will not be healthy or young, therefore further research into material modifications have been started to improve outcomes in compromised patients. The body’s immune system will generate a response to any implanted material, and control the final outcome. Among the first and most …

Plasmon-Enhanced Optical Sensing By Engineering Metallic Nanostructures, Peng Zheng

Graduate Theses, Dissertations, and Problem Reports (ETD)

The world’s booming population projected to reach 10 billion by 2050 causes enormous stresses on environmental safety, food supply, and healthcare, which in return threatens human civilizations. One of the most promising solutions lies at innovating point-of-care (POC) sensing technologies to conduct detection of environmental hazards, monitoring of food safety, and early diagnosis of diseases in a timely and accurate manner. The discovery of surface-enhanced spectroscopy in the 1970s has significantly stimulated research on light-matter interaction which gives rise to enhanced optical phenomena such as surface-enhanced Raman scattering (SERS), plasmon-enhanced fluorescence (PEF), and particularly, they have found enormous applications in …

Bowel Sounds Identification And Migrating Motor Complex Detection With Low-Cost Piezoelectric Acoustic Sensing Device, Xuhao Du, Gary Allwood, Katherine Mary Webberley, Adam Osseiran, Barry J. Marshall

Research outputs 2014 to 2021

Interpretation of bowel sounds (BS) provides a convenient and non-invasive technique to aid in the diagnosis of gastrointestinal (GI) conditions. However, the approach’s potential is limited by variation between BS and their irregular occurrence. A short, manual auscultation is sufficient to aid in diagnosis of only a few conditions. A longer recording has the potential to unlock additional understanding of GI physiology and clinical utility. In this paper, a low-cost and straightforward piezoelectric acoustic sensing device was designed and used for long BS recordings. The migrating motor complex (MMC) cycle was detected using this device and the sound index as …

Inorganic Biodegradable Substrates For Devices And Systems, Chang-Soo Kim, Richard K. Brow, D. E. Day

Electrical and Computer Engineering Faculty Research & Creative Works

Disclosed are biodegradable glass substrates that are useful as functional elements of solid-state devices. In particular, biodegradable glass substrates having a rapidly degradable glass and a slowly degradable glass provide a structural platform that completely dissolves following a desired operational lifetime of devices such as implanted electronic devices, implanted sensor devices, and optical fibers.

Next Generation Sequencing Technologies For Real-Time Genotyping And Targeted Sequencing For Precision Medicine, Priyanka Rawat

Biomedical Engineering ETDs

Astounding success of Human genome project and accelerating success of sequencing technologies have enabled $ 1000 genome goals possible. But, this is still far-fetched from the reach of many resource refrained populations with high genetic variations causing lethal genetic diseases. Based on present technology principles, I have developed prototypes for affordable, scalable and customizable point-of-care genotyping and targeted sequencing. Ion-sensitive field effect transistors with novel read-out and signal amplification techniques are used for laying foundation of possible ISFET based allele-arrays. Sequencing-by-synthesis based full-fledge sequencer is made with novel immobilization, flow-cell and data acquisition methods for massive sequenciing.

61st Conference On Senior Engineering Design, College Of Engineering And Applied Sciences

Senior Engineering Design Conference

The 61st Conference on Senior Engineering Design Projects. The conference was held from 9:00 a.m. to 2:00 p.m.,Tuesday, December 5, 2017 at the College of Engineering and Applied Sciences on the Parkview Campus of Western Michigan University. The College of Engineering and Applied Sciences sponsored the conference to showcase the work of its graduating seniors, who are required to complete a capstone project that puts into practice what they have learned. Many of the projects are sponsored by business and industry.

Green Chemistry Oxidative Modification Of Peptoids Utilizing Bleach And Tempo, Jesse Leland Roberts

Graduate Theses and Dissertations

Biotherapeutic drugs, derived from biological molecules such as proteins and DNA, are becoming an integral and exceptionally critical aspect of modern medicine. Compared to common pharmaceutical drugs, biotherapeutics are much larger in size and have greater target specificity, allowing them to treat many chronic diseases ranging from cancer to rheumatoid arthritis. The major issue with protein based therapeutics is that they readily undergo proteolysis, or enzymatic degradation, when administered through subcutaneous injections. Traditionally, biotherapeutic modification procedures have centered on the use of PEG derivatives. This process, called PEGylation, is unfavorable due to the increases in molecular weights of the proteins …

Proactive Sequential Resource (Re)Distribution For Improving Efficiency In Urban Environments, Supriyo Ghosh

Dissertations and Theses Collection (Open Access)

Due to the increasing population and lack of coordination, there is a mismatch in supply and demand of common resources (e.g., shared bikes, ambulances, taxis) in urban environments, which has deteriorated a wide variety of quality of life metrics such as success rate in issuing shared bikes, response times for emergency needs, waiting times in queues etc. Thus, in my thesis, I propose efficient algorithms that optimise the quality of life metrics by proactively redistributing the resources using intelligent operational (day-to-day) and strategic (long-term) decisions in the context of urban transportation and health & safety. For urban transportation, Bike Sharing …

Development Of Artificial Intelligence Approach To Nowcasting And Forecasting Oyster Norovirus Outbreaks Along The U.S. Gulf Coast, Shima Shamkhali Chenar

LSU Doctoral Dissertations

Oyster norovirus outbreaks pose increasing risks to human health and seafood industry worldwide. This study presents an Artificial Intelligence (AI)-based approach to identifying the primary cause of oyster norovirus outbreaks, nowcasting and forecasting the growing risk of oyster norovirus outbreaks in coastal waters. AI models were developed using Artificial Neural Networks (ANNs) and Genetic Programming (GP) methods and time series of epidemiological and environmental data. Input variable selection techniques, including Random Forests (RF) and Forwards Binary Logistic Regression (FBLR), were used to identify the significant model input variables among six independent environmental predictors including water temperature, solar radiation, gage height, …

Water, Sanitation, And Citizenship: Perceptions Of Water Scarcity, Reuse, And Sustainability In Valparaiso De Goias, Brazil, Paola Andrea Gonzalez

USF Tampa Graduate Theses and Dissertations

Access to reliable water and sanitation are two important goals to improve livelihoods around the world. Providing access to improved and safe water resources that are equitable and appropriate to local needs is important to improve sustainability long-term. In addition, framing access to water and sanitation as basic human rights is often used as a rationale in developing new water, sanitation, and hygiene interventions in developing countries around the world. But not all countries consider access to safe water and sanitation as a human right. In the thesis, the politics of improving and investment in water access and sanitation provision …

Aerosol Transport By Coughing In A Depressurized And Air-Conditioned Chamber, Bo Zhang

Dissertations

Expiratory droplets from human coughing in an air-conditioned environment have always been considered to be potential carriers of pathogens, responsible for respiratory disease transmission. The air movement/circulation and ambient conditions such as pressure and temperature are all key factors of aerosol transport. To study the transmission of disease by human coughing in a depressurized air-conditioned chamber, there are many technical challenges, including the following: 1) the study of simulating human coughing; 2) the collection of aerosol generated by coughing; 3) the CFD simulation of coughing-induced aerosol transport in an air-conditioned chamber; 4) the validation of such a CFD simulation by …

Rethinking The Design Of Low-Cost Point-Of-Care Diagnostic Devices, Faith W. Kimani, Samuel M. Mwangi, Benjamin J. Kwasa, Abdi M. Kusow, Benjamin K. Ngugi, Jiahao Chen, Xinyu Liu, Rebecca Cademartiri, Martin M. Thuo

Engineering Management and Systems Engineering Faculty Research & Creative Works

Reducing the global diseases burden requires effective diagnosis and treatment. In the developing world, accurate diagnosis can be the most expensive and time-consuming aspect of health care. Healthcare cost can, however, be reduced by use of affordable rapid diagnostic tests (RDTs). In the developed world, low-cost RDTs are being developed in many research laboratories; however, they are not being equally adopted in the developing countries. This disconnect points to a gap in the design philosophy, where parameterization of design variables ignores the most critical component of the system, the point-of-use stakeholders (e.g., doctors, nurses and patients). Herein, we demonstrated that …

Process Management And Design Layout Of High Throughput Screening, Anthony Vasquez, Kyle Dupuy

Industrial and Manufacturing Engineering

Calibr is a pharmaceutical company in San Diego and growing very quickly rate and need help redesigning their lab layout and in doing so reducing their cycle times and down times in machines. In addition to this, they do not currently have an accurate measurement of how long their processes take in an overall cycle. The objective of this project is to provide Calibr with a redesigned layout to accommodate new equipment as well as a software tool that can output Gantt charts for their planning of their testing. Our approach to this project first included mapping out the facilities …

Improved Single Molecule Detection Platform Using A Buried Arrow Design, Thomas Allen Wall

Theses and Dissertations

As the microelectronics industry pushes microfabrication processes further, the lab-on-a-chip field has continued to piggy-back off the industry's fabrication capabilities with the goal of producing total chemical and biological systems on small chip-size platforms. One important function of such systems is the ability to perform single molecule detection. There are currently many methods being researched for performing single molecule detection, both macro and micro in scale. This dissertation focuses on an optofluidic, lab-on-a-chip platform called the ARROW biosensor, which possesses several advantages over macro-scale single molecule detection platforms. These advantages include an amplification-free detection scheme, cheap parallel fabrication techniques, rapid …

The Future Is Coming : Research On Maritime Communication Technology For Realization Of Intelligent Ship And Its Impacts On Future Maritime Management, Jiacheng Ke

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

Past, Present And Future Of Surgical Meshes: A Review, Karen Baylón, Perla Rodríguez-Camarillo, Alex Elías-Zúñiga, Jose Antonio Díaz-Elizondo, Robert Gilkerson, Karen Lozano

Mechanical Engineering Faculty Publications

Surgical meshes, in particular those used to repair hernias, have been in use since 1891. Since then, research in the area has expanded, given the vast number of post-surgery complications such as infection, fibrosis, adhesions, mesh rejection, and hernia recurrence. Researchers have focused on the analysis and implementation of a wide range of materials: meshes with different fiber size and porosity, a variety of manufacturing methods, and certainly a variety of surgical and implantation procedures. Currently, surface modification methods and development of nanofiber based systems are actively being explored as areas of opportunity to retain material strength and increase biocompatibility …

Robust Odorant Recognition In Biological And Artificial Olfaction, Nalin Katta

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate detection and identification of gases pose a number of challenges for chemical sensory systems. The stimulus space is enormous; volatile compounds vary in size, charge, functional groups, and isomerization among others. Furthermore, variability arises from intrinsic (poisoning of the sensors or degradation due to aging) and extrinsic (environmental: humidity, temperature, flow patterns) sources. Nonetheless, biological olfactory systems have been refined over time to overcome these challenges. The main objective of this work is to understand how the biological olfactory system deals with these challenges, and translate them to artificial olfaction to achieve comparable capabilities. In particular, this thesis focuses …

Intravenous Administration Of Iron Oxide Nanoparticles In The Chicken Model, Huong Thi Ngoc Le

Graduate Theses and Dissertations

To be used in health care, the safety and effectiveness of nanoparticles needs to be tested in a living organism. The objective of this project was to develop the chicken as a convenient animal model to examine tissue targeting of intravenously (i.v.)-injected iron oxide (IO) nanoparticles. In Experiment 1, different doses of IO-COOH were i.v. injected into chickens; blood was collected at 0, 5, 15, 30, and 60 minutes post-injection; liver, spleen, lung, and kidney were collected after the last blood collection. For Experiment 2, IO-COOH and IO-PEG were i.v. injected into chickens; blood and the organs were collected at …

Removal Of Nitrates From Stormwater Using Nanoclays, Rubia Siddiqi

Master's Theses

Creeks and rivers are often polluted as a result of stormwater runoff that carries various contaminants in to open water bodies, causing adverse environmental and health effects. Low impact development (LID) techniques are currently employed to treat this runoff prior to discharge. Nitrate, however, is not consistently removed by these LID techniques. This study analyzed the ability of several nanoclays to remove nitrate in runoff and determined the feasibility of using them as a soil supplement for LID implementation. Six different nanoclays and HCl-treated clays were compared (pre-modified trimethyl stearyl ammonium nanoclay, pre-modified dimethyl dialkyl amine nanoclay, unmodified hydrophilic bentonite, …

Iot Based Recipes For Enabling Senior Citizens: Stakeholders Views On How Integration Of Iot And Web Services Can Enhance Well-Being And Inclusion Of Older People, Matteo Zallio, Damon Berry, John Mcgrory

Conference papers

The main body of research clearly highlights the world’s population is rapidly expanding. When this fact is combined with the increase in life longevity due to medical and social advances it alters the demographic balance in relation to age. Hence, the number of people aged 65 and over is constantly increasing. The potential of Smart Technologies and IoT-based devices to improve health has increased rapidly in the last few years and users are now in a position to contribute to the development of the interaction process and need to be properly trained on benefits of using new technologies. IFTTT (If …

Conference Program, Wilfred Chen, Nicole Borth, Stefanos Grammatikos

Biochemical and Molecular Engineering XX

No abstract provided.

The Effect Of Antigen Polymorphisms On Serological Antibody Detection Assays Based Upon The, Kristi M. Miley

USF Tampa Graduate Theses and Dissertations

Onchocerca volvulus is a filarial parasite transmitted to humans by female Simulium spp. black flies. Infection with this parasite can cause blindness and severe skin disease among humans in Africa and the Americas. Enzyme-linked Immunosorbent Assay serological testing of OV-16 antigen is a diagnostic tool for determining effective elimination of the parasite. Programs typically rely on OV–16 ELISA to evaluate the progress towards interruption and/or elimination of disease by mass drug distribution of ivermectin and vector larvicidal control efforts. As elimination grows closer, monoclonal antibody positive controls for OV-16 ELISA become important to develop for Onchocerca testing due to the …

Analysis Of A Potential A(H7n9) Influenza Pandemic Outbreak In The U.S., Walter A. Silva Sotillo

USF Tampa Graduate Theses and Dissertations

This dissertation presents a collection of manuscripts that describe development of models and model implementation to analyze impact of potential A(H7N9) pandemic influenza outbreak in the U.S. Though this virus is still only animal-to-human transmittable, it has potential to become human-to-human transmittable and trigger a pandemic. This work is motivated by the negative impact on human lives that this virus has already caused in China, and is intended to support public health officials in preparing to protect U.S. population from a potential outbreak of pandemic scale.

An agent-based (AB) simulation model is used to replicate the social dynamics of the …

Simulating Foodborne Pathogens In Poultry Production And Processing To Defend Against Intentional Contamination, Silas B. Lankford

Computer Science and Computer Engineering Undergraduate Honors Theses

There is a lack of data in recent history of food terrorism attacks, and as such, it is difficult to predict its impact. The food supply industry is one of the most vulnerable industries for terrorist threats while the poultry industry is one of the largest food industries in the United States. A small food terrorism attack against just a single poultry processing center has the potential to affect a much larger population than its immediate consumers. In this work, the spread of foodborne pathogens is simulated in a poultry production and processing system to defend against intentional contamination. An …

Manufacturing And Characterization Of A 3d-Printable, Antibacterial, Magnesium Oxide Nanoparticles Reinforced Abs Filament, Saket Thapliyal

Mechanical and Aerospace Engineering Theses - Archive

This research work consists of two phases. In phase one it is intended to manufacture an antibacterial 3D printable filament by extruding a solid state mixture of (MgO) nanoparticles (NPs) and Acrylonitrile Butadiene Styrene (ABS) pellets. A single screw extruder was used to extrude ABS pellets containing 0, 0.5, 1, 2 and 4 wt. % MgO NP. This phase deals with manufacturing and testing the filament for mechanical properties, antibacterial properties and 3D printability. On one hand tensile strength, ductility and 3D-printabiliy were observed to decrease with increasing concentrations of MgO NP in ABS matrix, on the other hand the …

Characterization Of Murine Breast Cancer Cell Lines For Anti-Cancer Vaccine, Haven N. Frazier

Biological Sciences Undergraduate Honors Theses

Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer death among women in the United States (1). While treatments involving radiation and chemotherapy currently exist, disease must be detected early in order for the treatments to be somewhat effective, and there is no effective treatment after metastasis occurs (2). Additionally, current therapies do not mitigate tumor immunosuppression. Decreasing the tumor-associated immunosuppressive conditions while activating antitumor immunity could prevent recurrence and metastasis, possibly leading to an effective treatment for cancer (3). Tumor cell vaccines could possibly address this issue and have become a …

Wright State University's Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts From Friday, April 21, 2017, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Annual Celebration of Research, Scholarship and Creative Activities on April 21, 2017.