Digital Commons Network^™

The Discrete-Event Modeling Of Administrative Claims (Demac) System: Dynamically Modeling The U.S. Healthcare Delivery System With Medicare Claims Data To Improve End-Of-Life Care, Rachael Chacko

Dartmouth College Undergraduate Theses

The shift of the U.S. healthcare delivery system from the treatment of acute conditions to chronic diseases requires a new method of healthcare system analysis to properly assess end- of-life (EOL) quality throughout the country. In this paper, we propose the Discrete-Event Modeling of Administrative Claims (DEMAC) system, which relies on a hetero-functional graph theory and discrete event-driven framework to dynamically model EOL care on multiple levels. The heat map visualizations produced by the DEMAC system enable the elucidation of not only patient-specific EOL care but also broader treatment patterns among providers and hospitals. As a whole, the DEMAC system …

Virus And Bacteria Inactivation Using Ultraviolet Light-Emitting Diodes, Vincent Martino, Kyra Oschsner, Paige Elyse Peters, Daniel Zitomer, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

The control of infectious diseases is a critical challenge in developing and developed nations alike. Humans can be exposed to pathogenic microorganisms such as viruses and bacteria through numerous routes of transmission, including waterborne transmission. Accordingly, effective water disinfection processes are paramount for public health protection. In this study, the inactivation efficacy of P22 virus and Escherichia coli bacteria was tested using ultraviolet light-emitting diodes (UV LEDs), which provided effective disinfection of both waterborne microorganisms. Using a peak wavelength emission of 255, 265, or 285 nm, the batch-test, UV LED collimated beam system demonstrated high inactivation potential for both microorganisms …

A Case Study On The Ucsf Transplant Center Renovation: Mitigating Covid-19 Risks And Tracking Cost Impact, Alec Steven Woodyatt

Construction Management

At the beginning of 2020, the world was turned upside down at the hands of the global coronavirus pandemic. Today, economies and business are counting the costs and wondering what recovery will look like – how to navigate and adapt to a new style of life after returning from government-mandated lockdowns. The question on everyone’s minds is, “how do we continue to work while keeping people safe?” This question is extremely relevant in the construction industry where, for most people, working from home is not an option. This case study will delve into how Dome Construction, along with their client, …

Stock Markets Performance During A Pandemic: How Contagious Is Covid-19?, Yara Abushahba

Theses and Dissertations

Background and Motivation: The coronavirus (“COVID-19”) pandemic, the subsequent policies and lockdowns have unarguably led to an unprecedented fluid circumstance worldwide. The panic and fluctuations in the stock markets were unparalleled. It is inarguable that real-time availability of news and social media platforms like Twitter played a vital role in driving the investors’ sentiment during such global shock.

Purpose:The purpose of this thesis is to study how the investor sentiment in relation to COVID-19 pandemic influenced stock markets globally and how stock markets globally are integrated and contagious. We analyze COVID-19 sentiment through the Twitter posts and investigate its …

Mitigation Of Airborne Contaminant Spread Through Simple Interventions In An Occupied Single-Family Home, Florida Solar Energy Center, Nazim Muradov

FSEC Energy Research Center®

Historically, reducing aerosol-based transmission of respired viruses in indoor environments has been of importance for controlling influenza viruses and common-cold rhinoviruses. The present public health emergency associated with SARS-CoV-2 makes this topic critically important. Yet to be tested is the potential effectiveness of simple interventions that create an isolation zone (IZ) for a suspected/confirmed sick or sensitive person requiring quarantine. The intent in existing homes is to find a practical means to mitigate exposure to airborne contaminants. In creating an IZ in an occupied single-family home in the study, four simple strategies were tested. The test configurations were: (1) IZ …

Design And Sensitivity Analysis Of Blood Supply Chain Network, The Merits Of Lateral Resupply, Mohammad Arani

Theses and Dissertations

The vibrant subject of blood banking and blood distribution is addressed where lateral resupply of blood products is allowed. In this research, a blood supply chain network design (BSCND) consisting of four conventional levels each of which corresponding to one entity in the real world is comprehensively studied: donors, blood collection facilities, blood centers, and hospitals. Two important properties are considered within the blood supply chain network (BSCN): ABO-Rh factors and shelf lives of blood products. Moreover, an integrated inventory system for sharing hospitals’ inventory levels is designed to investigate the two performance indicators of the network in terms of …

Introduction To Remote Sensing: Science For Society, Ronald J. Birk, Tsengdar Lee

Online Journal of Space Communication

Science for Society: Extending Earth Science Research Results into Decision Support Tools

Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.

PRC-Affiliated Research

A mixture of polyvinyl alcohol (PVA) and hydroxylammoniun nitrate (HAN) forms a gummy solid known as a plastisol, which is ionically conducting. When an electrostatic potential of 200 V DC is applied across the plastisol, it ignites. Combustion ceases upon removal of the applied voltage. The products of PVA + HAN combustion are known to include the molecular gases carbon monoxide, carbon dioxide, water, nitrogen, and hydrogen. When the electric field within the plastisol is spatially uniform, combustion occurs preferentially at the anode. The fact that HAN is an ionic conductor suggests that the mechanism of combustion is electrolytic in …

Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.

PRC-Affiliated Research

A mixture of polyvinyl alcohol (PVA) and hydroxylammoniun nitrate (HAN) forms a gummy solid known as a plastisol, which is ionically conducting. When an electrostatic potential of 200 V DC is applied across the plastisol, it ignites. Combustion ceases upon removal of the applied voltage. The products of PVA + HAN combustion are known to include the molecular gases carbon monoxide, carbon dioxide, water, nitrogen, and hydrogen. When the electric field within the plastisol is spatially uniform, combustion occurs preferentially at the anode. The fact that HAN is an ionic conductor suggests that the mechanism of combustion is electrolytic in …

Bibliometric Survey On Effect Of Socio-Economic Factors On Spread Of Corona Virus (Covid-19), Seema Patil Prof., Aayushi Verma Ms, Isha Patil Ms, Ravneesh Singh Mr, Raghav Gaur Mr

Library Philosophy and Practice (e-journal)

The Novel Coronavirus disease has been rapidly spreading all around the globe, from the time when it was first reported in the Wuhan city of China. The primary focus of this bibliometric survey is to distinguish the documents which have hypothesized and expanded on the effects of various socio-economic factors when it comes to the spread of the Coronavirus.

This survey does the evaluation on the 480 documents found. The United Kingdom of the Great Britain and United States have contributed the largest number of publications in this field of research followed closely by India and Italy.

The survey includes …

Plasmonically-Enhanced Ultrasensitive Biodetection Technologies, Zheyu Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Detection and quantification of biomolecules within biological fluids and tissues is of fundamental importance to biomedical research and clinical diagnostics. It is impossible to fully characterize complex, non-linear, biochemical systems without being able to accurately and quantitatively determine the component molecules. This problem is ubiquitous across all domains of biomedical research, and it is a major barrier to fully understanding health, ageing, and disease. Such bottlenecks are extremely challenging to be solved, especially for proteins and peptides, which do not have amplification schemes such as polymerase chain reaction for nucleic acids, because relevant concentrations of molecules related to diseases such …

A Deep Learning Model For Predicting Covid-19 Transmission In Connecticut, Nathan Choi

Honors Scholar Theses

COVID-19 has immensely impacted life as we know it, as the virus quickly spread throughout the entire world in a matter of weeks since its emergence. It has toppled economies, tested healthcare systems worldwide, and has un- fortunately taken the lives of many in the process. While extensive research has analyzed the issue on a large scale, focusing on entire countries and states, there has not been as much focus on the meso-scale, mainly compris- ing towns and cities, due to the lack of available COVID-19 data at this scale. However, in the case of countries like the United States …

Lab Home Testing Of Residential Isolation Space Control To Minimize Infectious Disease Transmission In Existing Single-Family Homes, Florida Solar Energy Center, Tanvir Khan

FSEC Energy Research Center®

Existing evidence strongly suggests that viral infectious diseases can be transmitted via an airborne route across distances in indoor environments. Accordingly, the risk of airborne transmission within homes should be managed. The public health emergency associated with SARS-CoV-2 makes controlling airborne transmission of respired viruses in indoor environments critical, especially in poorly ventilated indoor environments. The effectiveness of engineering interventions requiring minor efforts that create a negative-pressure isolation zone (IZ) for a contagious person has yet to be tested for existing residential homes.

To mitigate the risk of airborne virus transmission and maximize health protection for the population in existing …

Lab Home Testing Of Residential Isolation Space Control To Minimize Infectious Disease Transmission In Existing Single-Family Homes - Fact Sheet, Florida Solar Energy Center, Tanvir Khan

FSEC Energy Research Center®

The FSEC Energy Research Center at the University of Central Florida performed research to test the effectiveness of interventions to isolate an ill person recovering from a contagious disease in a single-family home from the rest of the occupants in the home. Focus was placed on interventions requiring minor cost and effort on the part of the occupants.

DOE/GO-102021-5537, https://www.nrel.gov/docs/fy21osti/79519.pdf

Water Exchange Rate Across The Blood-Brain Barrier Is Associated With Csf Amyloid-Β 42 In Healthy Older Adults, Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, Gregory A. Jicha, Donna M. Wilcock, Elayna R. Seago, Danny J. J. Wang

Sanders-Brown Center on Aging Faculty Publications

INTRODUCTION: We tested if water exchange across the blood-brain barrier (BBB), estimated with a noninvasive magnetic resonance imaging (MRI) technique, is associated with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and neuropsychological function.

METHODS: Forty cognitively normal older adults (67–86 years old) were scanned with diffusion‐prepared, arterial spin labeling (DP‐ASL), which estimates water exchange rate across the BBB (k_w). Participants also underwent CSF draw and neuropsychological testing. Multiple linear regression models were run with kw as a predictor of CSF concentrations and neuropsychological scores.

RESULTS: In multiple brain regions, BBB kw was positively associated with CSF amyloid …

Post Covid-19 Water And Waste Water Management To Protect Public Health And Geoenvironment, Ken Cornell, Arvin Farid

Chemistry and Biochemistry Faculty Publications and Presentations

The coronavirus disease 2019 pandemic has posed severe threats to humans and the geoenvironment. The findings of severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) traces in waste water and the practice of disinfecting outdoor spaces in several cities in the world, which can result into the entry of disinfectants and their by-products into storm drainage systems and their subsequent discharge into rivers and coastal waters, raise the issue of environmental, ecological and public health effects. The aims of the current paper are to investigate the potential of water and waste water to operate as transmission routes for Sars-CoV-2 and the …

Locating Drone Battery Supply Stations To Facilitate The Delivery Of Medical Supplies In Low And Middle-Income Countries, Madeline Suellentrop

Industrial Engineering Undergraduate Honors Theses

In the sub-Saharan region of Africa, the inability to perform emergency blood transfusions due to an inadequate blood supply has led to high fatality rates, especially among women and children. The prevalence of disease in this region limits the supply of local blood donations and, if blood is imported, then the region’s poor infrastructure inhibits fast distribution. There is a need for a technological update in the current process that overcomes the limitations of regional transportation, and drones present one promising solution for delivering small, lightweight items such as blood units. The current focus of this new delivery method is …

Mapping The Domain Of Rna Helicase Ddx1 That Interacts With The Ns1 Of Influenza A Viruses, Elise Wyatt

Biomedical Engineering Undergraduate Honors Theses

Of the known influenza virus strains, influenza A viruses (IAVs) are the most catastrophic due to their highly contagious nature and possibly life-threatening symptoms. IAVs invade a host cell and enter the nucleus where they use the cell’s nuclear machinery for replication of their viral RNA genome which is then exported to neighboring cells to establish a productive infection. Host pathogen recognition receptors (PRRs) respond to viral infection by signaling the cell to produce type I interferons (IFNs) to fight the foreign invader. Non-structural protein 1 (NS1) of IAVs, a major component in the regulation of viral replication, opposes host …

Engineering Controls For Bioaerosols In Non-Industrial/Non-Healthcare Settings, David Krause, Cheri Marcham, Bill Mele, Jack Springston, Rob Strode, Donald Weekes, Neil J. Zimmerman

Publications

The list of disease pathogens that can be transmitted in the air is extensive. This list includes the common cold, SARS, measles, Hansen’s disease (leprosy), polio, influenza, Legionella (Legionnaires’ disease and Pontiac fever), and tuberculosis (TB). TB, SARS-CoV-1, avian influenza, varicella, and now SARS-CoV-2 all have received public notice due not only to their known or assumed ability to be transmitted in the air rapidly from one individual to another, but also for their virulence. Other bioaerosols that can be transmitted through the air include bacteria, fungal spores and fragments, dust mites, and pollen. This document was developed to address …

Application Of Eh-Ph Diagrams On Acid Leaching Systems For The Recovery Of Rees From Bastnaesite, Monazite And Xenotime, Peijia Lin, Xinbo Yang, Joshua M. Werner, Rick Q. Honaker

Mining Engineering Faculty Publications

Bastnaesite, monazite and xenotime are rare earth minerals (REMs) that are typical sources for rare earth elements (REEs). To advance the understanding of their leaching and precipitation behavior in different hydrometallurgical processes, Eh-pH diagrams were constructed and modified using the HSC 9.9 software. The aqueous stability of rare earth elements in H₂O and acid leaching systems, i.e., the REE-Ligands-H₂O systems, were depicted and studied based on the Eh-pH diagrams. This study considers the most relevant lixiviants, their resulting equilibrium states and the importance in the hydrometallurgical recovery of rare earth elements (REMs). A literature review was …

Highly Branched Polymers Based On Poly(Amino Acid)S For Biomedical Application, Marisa Thompson, Carmen Scholz

PRC-Affiliated Research

Polymers consisting of amino acid building blocks continue to receive consideration for biomedical applications. Since poly(amino acid)s are built from natural amino acids, the same building blocks proteins are made of, they are biocompatible, biodegradable and their degradation products are metabolizable. Some amino acids display a unique asymmetrical AB2 structure, which facilitates their ability to form branched structures. This review compares the three forms of highly branched polymeric structures: structurally highly organized dendrimers, dendrigrafts and the less organized, but readily synthesizable hyperbranched polymers. Their syntheses are reviewed and compared, methods of synthesis modulations are considered and variations on their traditional …

Highly Branched Polymers Based On Poly(Amino Acid)S For Biomedical Application, Marisa Thompson, Carmen Scholz

PRC-Affiliated Research

Polymers consisting of amino acid building blocks continue to receive consideration for biomedical applications. Since poly(amino acid)s are built from natural amino acids, the same building blocks proteins are made of, they are biocompatible, biodegradable and their degradation products are metabolizable. Some amino acids display a unique asymmetrical AB2 structure, which facilitates their ability to form branched structures. This review compares the three forms of highly branched polymeric structures: structurally highly organized dendrimers, dendrigrafts and the less organized, but readily synthesizable hyperbranched polymers. Their syntheses are reviewed and compared, methods of synthesis modulations are considered and variations on their traditional …

Effects Of Carbon-Infiltrated Carbon Nanotube Growth On The Biocompatibility Of 316l Stainless Steel, Sterling Charles Voss

Theses and Dissertations

The purpose of this research is to identify the effects of the carbon-infiltrated carbon nanotube (CICNT) growth process on the material properties of 316L stainless steel, particularly those properties which are essential for biocompatibility. Physically altering the micro-topography of a surface can dramatically affect its capacity to support or prevent biofilm growth. Growing CICNTs on biomedical materials is one approach which has demonstrated success at preventing biofilm growth. Unfortunately, the high temperature and carbon-rich gas exposure required for this procedure has proven to have deleterious effects. Rusting has been observed on samples that have been coated with CICNTs and then …

Low Stress Handling Techniques In Shelter Animals And The Overall Effects On Physiological Parameters, Ashley Swim, Courtney Smart, Amy Staton

2021 Celebration of Student Scholarship - Oral Presentations

Animal shelters tend to be a very stressful environment for dogs as there are many new sounds, smells, and animals. This stress is not only bad for their psychological health and can lead to behavioral issues, but it can also have an impact on their physical health. Stress impacts multiple systems of the body, resulting in increased heart rate, blood pressure, respiratory rate, temperature and even blood glucose levels in dogs. The impact stress has on these systems can lead to a compromised immune system and increases the probabilities of the dog becoming ill. However, by using Fear Free methods, …

Assistive Robotics And Their Uses During The Pandemic, Thomas Klassen, Jeremy Evert

Student Research

• “Assistive Robotics” defines any device that can sense, process sensory information, and perform actions that benefit people with disabilities.

• This form of technology can be used on a much higher scale with a greater number of uses.

• We have an opportunity to expand the usage of assistive robotics to help combat COVID-19.

Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye

Faculty Publications

The relevance of multidimensional and porous crystalline materials to nuclear waste reme-diation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8 Na1.2 [(UO2)BSi4 O12 ] has been synthesized using hydrothermal methods, rep-resenting the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4 O12 ]5− chains to …

Past The Tipping Point, But With Hope Of Return: How Creating A Geoengineering Compulsory Licensing Scheme Can Incentivize Innovation, Brooke Wilson

Washington and Lee Journal of Civil Rights and Social Justice

This Note explores the patenting of geoengineering technologies and issues arising from the early stages of this high-risk, high-reward technology. This Note focuses on one possible solution to solving the issues surrounding the patenting of geoengineering technology: Creating a specialized compulsory licensing scheme.

Exploring A New Housing Design Paradigm For Post Pandemic Multi-Story Buildings In Lebanon, Rachid M. Hajjar

Architecture and Planning Journal (APJ)

When the fast-spreading COVID-19 was announced as a pandemic by the World Health Organization (WHO), people around the world rushed to go home. This worldwide widespread altogether affected our individual and proficient lives and features a coordinate bearing upon the exceptionally establishments of design hypothesis. As a result, the pandemic has contributed to concerns about how architects and designers should view and install antivirus-related ideas or redesign current spaces, as well as at what point our physical and built environment could be impacted by the pandemic. In forecasting the post-pandemic style and visualizing the appropriate antivirus scheme, the answers to …

Slowing The Spread Of Covid-19: Review Of “Social Distancing” Interventions Deployed By Public Transit In The United States And Canada, Camille Kamga, Penny Eickemeyer

Publications and Research

This paper presents a review of social distancing measures deployed by transit agencies in the United States and Canada during the COVID-19 pandemic and discusses how specific operators across the two countries have implemented changes. Challenges and impacts on their operations are also provided.

Social distancing is one of the community mitigation measures traditionally implemented during influenza pandemics and the novel coronavirus pandemic. Research has shown that social distancing is effective in containing the spread of disease. This is applicable to the current situation with the novel coronavirus, given the lack of effective vaccines and treatments in the United States …

Network-Based Analysis Of Early Pandemic Mitigation Strategies: Solutions, And Future Directions, Pegah Hozhabrierdi, Raymond Zhu, Maduakolam Onyewu, Sucheta Soundarajan

Northeast Journal of Complex Systems (NEJCS)

Despite the large amount of literature on mitigation strategies for pandemic spread, in practice, we are still limited by naive strategies, such as lockdowns, that are not effective in controlling the spread of the disease in long term. One major reason behind adopting basic strategies in real-world settings is that, in the early stages of a pandemic, we lack knowledge of the behavior of a disease, and so cannot tailor a more sophisticated response. In this study, we design different mitigation strategies for early stages of a pandemic and perform a comprehensive analysis among them. We then propose a novel …