Digital Commons Network^™

Accelerating Neurotechnology Development Using An Agile Methodology, Anil Kumar Thota, Ranu Jung

Biomedical Engineering Faculty Publications and Presentations

Novel bioelectronic medical devices that target neural control of visceral organs (e.g., liver, gut, spleen) or inflammatory reflex pathways are innovative class III medical devices like implantable cardiac pacemakers that are lifesaving and life-sustaining medical devices. Bringing innovative neurotechnologies early into the market and the hands of treatment providers would benefit a large population of patients inflicted with autonomic and chronic immune disorders. Medical device manufacturers and software developers widely use the Waterfall methodology to implement design controls through verification and validation. In the Waterfall methodology, after identifying user needs, a functional unit is fabricated following the verification loop (design, …

Investigating The Effects Of Alcohol Consumption On Manual And Automated Driving: A Systematic Review, Miaomiao Dong, Yuni Lee, Jackie Cha, Gaojian Huang

Mineta Transportation Institute

There are direct correlations between drunk driving and car-related injuries, disabilities, and death. Autonomous vehicles (AVs) may provide useful driver support systems to prevent or reduce road accidents. However, AVs are not yet fully automated and require human drivers to take over the vehicle at times. Therefore, understanding how alcohol affects driving performance in both manual and automated driving is important because manual drives may offer insights into the takeover process in AVs. A systematic review of 53 articles from eight databases was conducted. Findings were categorized based on the human information processing model, which can be extended to the …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction-a measure of …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction—a measure of …

Quaternary Ammonia Compounds In Disinfectant Products: Evaluating The Potential For Promoting Antibiotic Resistance And Disrupting Wastewater Treatment Plant Performance, Zihao Lu, Anna K. Mahony, William A. Arnold, Christopher Marshall, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Quaternary ammonium compounds (QACs) are a class of compounds that were widely used as disinfectants during the COVID-19 pandemic and continue to be used as disinfecting agents. After consumer usage, QAC concentrations are diluted in wastewater as they enter wastewater treatment plants. At sub-inhibitory concentrations, QACs may have unintended repercussions, including increased antibiotic resistance and inhibition of process performance in wastewater treatment plants. This review first summarizes how QACs inhibit bacteria and then highlights the mechanisms by which QACs can promote antibiotic resistance in general. Reported environmental concentrations of QACs are compared to concentrations that are suspected to impact antibiotic …

Nanoparticles For Applications In Specific Diagnostics And Precision Medicine, Naxhije Berisha

Dissertations, Theses, and Capstone Projects

Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations …

Containerization Of Seafarers In The International Shipping Industry: Contemporary Seamanship, Maritime Social Infrastructures, And Mobility Politics Of Global Logistics, Liang Wu

Dissertations, Theses, and Capstone Projects

This dissertation discusses the mobility politics of container shipping and argues that technological development, political-economic order, and social infrastructure co-produce one another. Containerization, the use of standardized containers to carry cargo across modes of transportation that is said to have revolutionized and globalized international trade since the late 1950s, has served to expand and extend the power of international coalitions of states and corporations to control the movements of commodities (shipments) and labor (seafarers). The advent and development of containerization was driven by a sociotechnical imaginary and international social contract of seamless shipping and cargo flows. In practice, this liberal, …

Vaccine Immunogenicity Versus Gastrointestinal Microbiome Status: Implications For Poultry Production, Chrysta N. Beck, Jiangchao Zhao, Gisela F. Erf

Poultry Science Faculty Publications and Presentations

At the turn of the 21st century, the importance of maintaining a balanced microbiome was brought to the forefront of the microbiology, immunology, and physiology research fields. Exploring the complex interactions between vaccine administration, mucosal microbiome, oral tolerance, and enteric inflammation in health and disease is challenging since environmental factors (such as diet and sanitation) have major influences on gut microbiota composition. High enteric pathogen load has been shown to contribute to dampened cell-mediated and humoral immune responses to vaccines in human case studies, either through elevated enteric inflammation or increased tolerance to environmental microbes. Although antibiotic and probiotic interventions …

Development Of Monitoring Systems Using Computer Vision Techniques For Precise Fish Farming, Abinaya N.S

Theses and Dissertations

Fish farm is a biosystem with diversity and uncertainties demanding, an intelligent manual monitoring process, which is labor-intensive, invasive, costly, discontinuous, and persistent. The proposed work aims to develop Computer Vision (CV) -based monitoring techniques for precise fish farming to address these problems. Three major monitoring operations namely (i) Fish behavior analysis, (ii) Fish Classification (FC) and (iii) Biomass estimation have been investigated.

Fish schooling activity has been monitored using an overhead vision camera. Problems associated with fish occlusion are addressed using the weighted K-means clustering technique which provides an accurate estimation of fish school locations. Temporal variations of these …

Development Of An Electromagnetic System For Wireless Magnetic Manipulation Of Soft Capsule Endoscope For Drug Delivery Applications, Nada Ashraf Hussein Mahmoud

Theses and Dissertations

Wireless capsule endoscopy (WCE) is a remarkable diagnostic device that examines the gastrointestinal (GI) tract. The WCE is a small capsule integrated with a camera that is used to visualize the inner mucosa of the GI tract. WCE has been proven to be the most effective method to diagnose GI diseases and GI cancers. The procedure reduces the discomfort and risk compared to conventional endoscopy methods. However, current WCEs lack the ability to take a biopsy or deliver a drug to a specific location. Those therapeutic functions can be introduced by wirelessly controlled WCEs. This thesis introduces an electromagnetic system …

Cardiac Active Tension Modeling Via Genetic Algorithm-Optimized Fractional Order Systems, Afnan Khaled Elhamshari

Theses and Dissertations

Developing a computational model to model cardiac activity has been increasingly important in recent decades. Accurate cell-level active tension modeling for cardiomyocytes is critical to understanding cardiac functionality on a patient-specific basis and developing an effective in-silico cardiac model. However, cell-level models in the literature fail to account for viscoelasticity and inter-patient variations in active tension. This research proposes a genetic algorithm-optimized, fractional order system to model cell-level active tension by extending Land’s state-of-the-art model of cardiac contraction. The model features the (left) Caputo derivative of six state variables that identify the mechanistic origins of viscoelasticity in a myocardial cell …

The Effect Of Mechanical Strain On The Electronic Conductivity Of Α- Fe2o3: A Density Functional Theory Study, Sheriff Naziru Abdulmutalib

Theses and Dissertations

Hydrogen has emerged as a promising future energy carrier due to its ability to produce zero carbon dioxide (CO2) emissions when burned. However, the limited natural abundance of hydrogen necessitates the development of cost-effective and environmentally friendly methods for large-scale hydrogen production. Among the different hydrogen production approaches, photoelectrochemical water splitting, which employs a photoanode material in a cell using solar energy to split water into hydrogen and oxygen, is the focus of this work. α-Fe2O3 (hematite) is a photoanode material that shows a promising future for hydrogen generation in a photoelectrochemical cells due to its cheapness, availability, and its …

Improving The Energy Efficiency Of Residential Buildings In Egypt Through Whole Building Simulations, Habiba Aly

Theses and Dissertations

Residential buildings consume around 40% of total electricity consumption in Egypt. This research investigates the energy saving potential of the Green Pyramid Rating system (GPRS) and Tarsheed rating system on the building envelopes of mid-rise middle income residential buildings in Cairo through energy modelling and simulation. The study evaluates the economic feasibility of the recommendations of the two rating systems through Life Cycle Cost (LCC), Simple Payback Period (SPP), Discounted Payback Period (DPP), Net Present Value (NPV), and Internal Rate of Return (IRR) Calculations. This research also aims to develop energy efficiency recommendations to achieve 30% energy savings above the …

Profess 12: Project Report 5: The Profess 12 Summer School - Evaluation, Una Beagon, Ruchita Jani, Janet Mckennedy, Brian Bowe, Margaret Morgan, Rosalind M Henry

Reports

This report outlines the evaluation of the summer school which was a key element of the PROFESS 12 project. The key steps involved in the 5-day summer school along with the method by which the feedback and the reflections of the participants of the summer school were collected is described here. Thereafter, the reflections received in the form of audio and text files are analysed and themes identified from the experience of the summer school participants are explained in detail.

The survey responses from the feedback on the summer school participation are also shown graphically. This analysis helped us identify …

Reliable Outdoor Ai-Based Autonomous Uav Localization And Trajectory Tracking Using Cellular Networks, Ghada Afifi

Theses and Dissertations

Unmanned aerial vehicles (UAVs) are becoming an integral part of numerous commercial and military applications. In many of these applications, the UAV is required to self-navigate in highly dynamic urban environments. Existing localization and trajectory planning techniques, which rely mainly on the Global Positioning System (GPS), do not provide an effective real-time solution for self-localization and path planning, particularly in dense urban environments. The purpose of this thesis is to study the localization and trajectory planning of UAVs independent of GPS systems or other detectable mobile signals. We propose to utilize the broadcast signals from existing cellular networks to localize …

Tree Localization In A Plantation Using Ultra Wideband Signals, Akshat Verma

The Journal of Purdue Undergraduate Research

No abstract provided.

Biodiesel Transesterification Of Spent Coffee Grounds Using Dbu As A Catalyst: Using Dbu To Make Biodiesel From Coffee Grounds, Christopher Stepherson, Pericles Karras, Amy Ha, Phuc Tan Nguyen, Abigail Pati, Jacob Hejazi, Soheil Hussain, Elizabeth De Young, Shuaicheng Fu

The Journal of Purdue Undergraduate Research

Coffee is one of the most universally consumed beverages. The world produces 60 million tons of spent coffee grounds (SCGs) as waste per year. Biodiesel made from SCGs is an eco-friendly alternative fuel but proves difficult to produce. 1,8-Diazabicyclo[ 5.4.0]undec-7- ene (DBU) was used as both a solvent and a catalyst with methanol to determine the efficiency of biodiesel production from SCGs. The process was completed by extracting coffee oil from acid-washed spent coffee grounds (AWSCGs) using hexane. The two extraction methods that were explored were Soxhlet and agitation. DBU is an interesting choice as a solvent and a catalyst …

Miniaturized Fluorescence Ph Sensor With Assembly Free Ball Lens On A Tapered Multimode Optical Fiber, Bohong Zhang, Farhan Mumtaz, Muhammad Roman, Dinesh Reddy Alla, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

In biochemistry, the absence of a compact, assembly-free pH sensor with high sensitivity and signal-to-noise ratio has been a persistent hurdle in achieving accurate pH measurements in real time, particularly in complex liquid environments. This manuscript introduces what we believe to be a novel solution in the form of a miniaturized pH sensor utilizing an assembly-free ball lens on a tapered multimode optical fiber (TMMF), offering the potential to revolutionize pH sensing in biochemical applications. A multimode optical fiber (MMF) was subjected to tapering processes, leading to the creation of an ultra-thin needle-like structure with a cross-sectional diameter of about …

Hygrothermal Risk Assessment Of External Wall Insulation Retrofit To Non-Traditional Wall Types In An Irish Context, Using The Glaser Method And A Heat, Air And Moisture Transient Model, Gareth Mcdonnell, Joseph Little

Articles

The Climate Action Plan 2019 targets the low-energy retrofit of 500,000 existing Irish homes before 2030.1 Up to 80 per cent of building failures can be attributed to moisture risks.2 The literature indicated that external wall insulation (EWI, ETICS) failures are mostly due to moisture ingress at junctions and interfaces. A hygrothermal risk assessment of EWI on three walls with rendered concrete/concrete blockwork/cavity walls in Dublin, Belfast and Belmullet was undertaken using transient numerical simulation and the Glaser method. The guidance, common practice indicates a preference for Glaser. The initial simulation results were compared to assess the appropriateness of Glaser. …

Digital Transformation And Design For Maintainability In Industrial Design, Ahmed Tarek Mohamed Fathy, Salwa El Ghareeb, Yasser Shaban

Journal of Art, Design and Music

In this paper, we explore the impact of the rapid digital transformation in Applied Arts and Design and its influence on the realm of Maintainability. We examine how CAD, 3D modeling, have revolutionized the conceptualization and prototyping stages, enabling precise idea communication and immersive representations. Specifically, we focus on Design for Maintainability (DfMn) and its critical aspects such as repairability, serviceability, maintainability, and reliability, which significantly affect cost and user satisfaction. By leveraging this tool, designers can create highly maintainable and user-friendly products. The transformative potential of this tool in industrial design is highlighted, providing promising avenues for future research …

Unveiling Efficiency: Investigating Distance Measures In Wastewater Treatment Using Interval-Valued Neutrosophic Fuzzy Soft Set, Muhammad Saeed, Kinza Kareem, Fatima Razzaq, Muhammad Saqlain

Neutrosophic Systems with Applications

To reduce the threats that wastewater poses to human health and the environment, water treatment techniques must be improved. The use of a procedure that includes preparation, testing, primary and secondary treatments, filtration, disinfection, and continuous monitoring is therefore required. The objective of this research is to create a hybrid notion that extends the idea of an interval-valued neutrosophic fuzzy soft set (IVNFSS) to an interval-valued neutrosophic fuzzy set. Operations like complement, union, and integration are included in the idea. To improve decision-making accuracy, a quality-assessment distance measure is incorporated, offering a numerical representation of the disparity between various factors. …

Investigation Of Machine Learning Driven Adaptive Control Strategy For Heat Exchanger Under Varying Fouling Conditions, Reshma Madhu Pk

Theses and Dissertations

Fouling is an undesirable and inevitable phenomenon that affects Heat Exchanger (HE) dynamics, increases maintenance cost (>50%), and loss of production. Conventional fouling prediction and control techniques demand an in-depth understanding of the HE-specific fouling dynamics. Hence, machine learning emerges as an ideal tool for learning the fouling process from the available measurement dataset.

The proposed work aims to design a machine learning-driven adaptive control technique for an industrial HE, subjected to varying fouling conditions. Naphtha cooler, an industrial HE utilized in petroleum refineries, employs cooling water to lower Naphtha temperature, but the high impurities in the recycled cooling …

Hydrochemistry Characteristics And Genesis Mode Of Hot Springs In The Luolou River Basin, Yunnan, China, Luo Huan, Liu Zhennan, Ma Yiqi, Zhang Yunhui, Tao Lanchu, Chen Qingsong, Fu Dunkai, Wu Xiangchuan

Coal Geology & Exploration

The hydrochemistry and genesis mechanism of thermal springs hold great significance for the exploitation and utilization of low to intermediate temperature geothermal resources. Under the influence of a concealed fault zone, thermal springs in the Luolou River basin, Yunnan Province, are distributed along both sides of valleys and exposed in Quaternary loose deposits and Permian basalt strata. It belongs to low to intermediate temperature thermal spring water, with temperatures ranging between 34.5 and 50.0℃, pH is between 7.62-9.73, TDS is between 262-702 mg/L. Based on the hydrochemical and isotopic tests of thermal spring samples and nearby cold water samples from …

Unveiling Efficiency: Investigating Distance Measures In Wastewater Treatment Using Interval-Valued Neutrosophic Fuzzy Soft Set, Muhammad Saeed, Kinza Kareem, Fatima Razzaq, Muhammad Saqlain

Neutrosophic Systems with Applications

To reduce the threats that wastewater poses to human health and the environment, water treatment techniques must be improved. The use of a procedure that includes preparation, testing, primary and secondary treatments, filtration, disinfection, and continuous monitoring is therefore required. The objective of this research is to create a hybrid notion that extends the idea of an interval-valued neutrosophic fuzzy soft set (IVNFSS) to an interval-valued neutrosophic fuzzy set. Operations like complement, union, and integration are included in the idea. To improve decision-making accuracy, a quality-assessment distance measure is incorporated, offering a numerical representation of the disparity between various factors. …

Power Grid Resiliency Enhancement Against Flood-Induced Hazards, Mohadese Movahednia

LSU Doctoral Dissertations

Natural disasters, such as floods, may damage power system assets and lead to widespread and long outages. The impact of flood can be alleviated by preventive actions such as installing tiger dams around power substations before the flood. In this regard, it is imperative that critical substations are identified in terms of the connected load and imposed costs to the system. This study presents a resource allocation approach for protecting power substations against flood events a day ahead of the event. First, the required information for the model is extracted. Flood probability distribution functions are used to generate several flood …

No Difference In Pullout Strength Between A Bio-Inductive Implant And A Semitendinosus Tendon Graft In A Biomechanical Study Of Medial Patellofemoral Ligament Repair Augmentation, Austin Wetzler, Sean Mcmillan, Erik Brewer, Aakash Patel, Samuel Handy, Merrick Wetzler

Rowan-Virtua School of Translational Biomedical Engineering & Sciences Departmental Research

Purpose: To compare the pullout strength of a bio-inductive implant (BI) used to augment a medial patellofemoral ligament (MPFL) repair with the pullout strength of semitendinosus graft in a biomechanical cadaveric model. Methods: Six matched pairs of cadavers (12 knees) were used in the biomechanical testing comparing semitendinosus tendon (Semi-T) versus a BI. The Semi-T was harvested from 1 of the matched pairs. A standard double-bundle technique using 2 sockets in the upper two-thirds of the patella 15 mm apart was performed. After docking of the graft into the patella, the patella was dissected free of soft tissues and potted …

Application Of Learning Processes For Improving Last-Mile Logistics Optimization At Scale, Seyedeh Shaghayegh Rabbanian

LSU Doctoral Dissertations

The escalating demands of omnichannel retailing, rapid urbanization and shifting customer behaviors have propelled last-mile vehicle routing logistics to the forefront of research. This last-mile phase, recognized as a significant contributor to costs and pollution in the supply chain, necessitates efficient route optimization to minimize expenses and environmental impact. This research delves into machine learning based techniques for solving large-scale Vehicle Routing Problem (VRP), a fundamental concern in last-mile logistics, aiming to optimize delivery vehicle routing amidst diverse customer nodes and operational constraints. Three primary research subproblems are analyzed: utilizing machine learning for constructive solutions, Variable Neighborhood Search (VNS) metaheuristic, …

Integrated Project Delivery (Ipd): A Contractual Framework For The Egyptian Construction Industry, Sarah Hussain

Theses and Dissertations

This abstract highlight the significant findings and contributions of the study, which aimed to develop model clauses specifically tailored to the Egyptian construction industry for multi-party construction contracts. The research methodology encompassed several key components. Firstly, a comprehensive literature review was conducted to explore the various construction delivery methods prevalent in Egypt. This review provided a solid foundation for understanding the existing practices and identifying areas for improvement. The study also delved into the concept of Integrated Project Delivery (IPD) and its potential benefits as well as an analysis of the commonly used standard forms of contract and successful case …

Enhancing The Tribological Performance Of Prosthetic Implants: An Investigation Of Cnc Surface Micro-Texturing On Uhmwpe, Javier Ortega, J. Perez, N. Perez

Research Symposium

Background: Annually, there are over a million joint replacement procedures and more than 250,000 revision surgeries in the United States. The typical lifespan of a joint replacement ranges from 7 to 15 years, often curtailed by complications such as excessive implant wear leading to infections and joint dislocations. Given that most joint replacement recipients are between the ages of 50 and 70, the later part of their lives is often marred by repeated surgeries and discomfort. Presently, the predominant material used in joint replacements is medical-grade Ultra-High Molecular Weight Polyethylene (UHMWPE) with smooth surfaces. While these smooth surfaces are believed …

Love Machina, John C. Lyden

Journal of Religion & Film

This is a film review of Love Machina (2024), directed by Peter Sillen.