Digital Commons Network^™

Volatile Crystalline Semiconductor Core Fibers, Thomasina Zaengle

All Dissertations

Optical fibers play critical roles across many facets of everyday life from communications to e-commerce to sensing and security. The ubiquity of optical fibers arises from their intrinsic clarity and, as glasses, their ability to be thermally drawn at high speeds over long distances when suitably heated about their glass transition temperature. Sixteen years ago, the first thermally drawn crystalline core fibers were fabricated using the molten core method, whereby a melt is confined within a glass capillary tube that is then drawn to fiber. This opened the door to crystalline semiconductor core fibers, which are now the backbone of …

Evacuation Of Students With Intellectual Disability In Building Fires: A Three-Part Methodology, Haley Hostetter

All Dissertations

People with disabilities are one of the most vulnerable groups in building fires. Despite this, they have traditionally been overlooked by fire evacuation researchers. This is perhaps the most alarming for the group with Intellectual Disability when given their present statistics for fire involvement, injuries, and death. Annually, people with mental disabilities are involved in 1700 home fires, resulting in 39 fatalities and 122 injuries per 1000 fires. Additionally, 40% of these fires were started intentionally by people with mental disabilities. When combined with their high fire risk, the lack of evacuation research focused on people with Intellectual Disability shows …

Real-Time Degradation Abatement Framework For Energy Storage System In Automotive Application Using Data-Driven Approaches, Laxman Timilsina

All Dissertations

The increasing popularity of electric vehicles (EVs) is driven by their compatibility with sustainable energy goals. However, the decline in the performance of energy storage systems, such as batteries, due to their degradation puts EVs and hybrid electric vehicles (HEVs) at a disadvantage compared to traditional internal combustion engine (ICE) vehicles. The batteries used in these vehicles have limited life. The degradation of the battery is accelerated by the operating conditions of the vehicle, which further reduces its life and increases the reliability and economic concerns for the vehicle’s operation. The aging mechanism inside a battery cannot be eliminated but …

Trust Model Measurements For The Energy Grid Of Things, N. Sonali Fernando, John M. Acken, Robert Bass

Electrical and Computer Engineering Faculty Publications and Presentations

Information security is essential for the reliable operation of an Energy Grid of Things (EGoT). In addition to basic information security protocols as defined by published standards, there is a need for a monitoring function that measures the trustworthiness of the various actors participating in an EGoT. We describe in this paper the implementation and evaluation of a Distributed Trust Model that was developed specifically for monitoring communication within an EGoT. We then show how the model parameters are set using statistical measures for hypothesis testing.

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Investigation Into The Effect Of Mixture Composition On Setting Time Of Magnesium Phosphate Cement, Autumn Broglen

Civil Engineering Undergraduate Honors Theses

Magnesium phosphate cement (MPC) is a cementitious material that is formed through an acid-base reaction between magnesia and phosphate. This reaction occurs rapidly, making MPC an appealing choice for rapid repair applications. The purpose of this project is to investigate the impact of different proportions of class F fly ash, set retarder consisting of a mixture of boric acid and dextrose, magnesium to phosphate ratio, and water/cement ratio on the initial setting time of MPC paste. Different mixtures of MPC paste were developed to vary the proportions of each constituent, and setting time of each mixture was determined using the …

Automated Brain Tumor Classifier With Deep Learning, Venkata Sai Krishna Chaitanya Kandula

Electronic Theses, Projects, and Dissertations

Brain Tumors are abnormal growth of cells within the brain that can be categorized as benign (non-cancerous) or malignant (cancerous). Accurate and timely classification of brain tumors is crucial for effective treatment planning and patient care. Medical imaging techniques like Magnetic Resonance Imaging (MRI) provide detailed visualizations of brain structures, aiding in diagnosis and tumor classification^[8].

In this project, we propose a brain tumor classifier applying deep learning methodologies to automatically classify brain tumor images without any manual intervention. The classifier uses deep learning architectures to extract and classify brain MRI images. Specifically, a Convolutional Neural Network (CNN) …

Reduction Of The Length Of Stay At The Emergency Department Of The Audie L. Murphy Hospital, Arwa Al Shikrian

Theses

We implemented the DMAIC framework (Define, Measure, Analyze, Improve, and Control) and Lean Six Sigma methods to reduce the length of stay (LOS) in the Emergency Department (ED) at Audie L. Murphy VA Hospital, a crucial issue affecting operational efficiency and patient care quality. This project was conducted in conjunction with an internship at the Hospital; our efforts were an integral part of a Green Belt project being conducted by Mr. Roarke Verkaik-Bushby, Hospital Administration Service, to

whom this author reported.

We employed quantitative research design, meticulously observing, measuring, and analyzing ED processes. We tracked patient flow, identified bottlenecks, and …

Pedestrian Crossing Environmental Impact Statement, Alyssa Gaither

Undergraduate Honors Capstone Projects

Logan, Utah is divided by US Highway 89/91, which bisects much of the city. This makes it difficult to pass to the other side without a vehicle. A pedestrian crossing has been proposed to connect the eastern and western sides of Logan without impacting traffic flow. The Environmental Impact Statement aims to look at reasonable alternatives and identify many resources that will be affected by its implementation. Four main alternatives were considered: an underpass, an overpass with an elevator, an overpass with a ramp, and the no-change alternative to be used as a baseline alternative. The underpass is the preferred …

Testing Resilience Of Microalgae Biofilms When Exposed To Hydrothermal Liquefaction Aqueous Phase, Davis Riley Haag

Undergraduate Honors Capstone Projects

There are a multitude of experimental and processing techniques in the bioenergy field that produce sustainable and carbon negative to carbon neutral methods of converting renewable resources into biologically based hydrocarbons. One example of a process is hydrothermal liquefaction (HTL) which specializes in converting wet biomass into biocrude oil. One reason that these processes are not used outside experimental testing is due to the high cost of performing these processes. There is potential to move these processes to larger scale testing and eventually industrial adaptation if breakthroughs are made to offset the process expenses. There is a waste product produced …

Suppressing Reactive Oxygen Species Via Application Of Antioxidant Supramolecular Polymers, Zacchaeus Wallace

Honors Theses

Cardiovascular diseases along with various other disease conditions are characterized by an upregulation in reactive oxygen species (ROS), which can overwhelm homeostatic processes in the body, resulting in cellular apoptosis and severe oxidative damage. The lack of clinically approved treatments to regulate or alleviate this elevated ROS presence underscores the need for novel therapeutic strategies. While antioxidants promote cell rescue through ROS scavenging, their clinical translation is impeded by insufficient bioavailable concentrations at the source of injury. The opportunity to apply antioxidant supramolecular polymers of peptide amphiphiles (PAs) is an exciting prospect of research to combat corresponding issues. For this …

Earth Abundant Catalyst For Evironmental Sustainability Applications, Javier Hernandez

Open Access Theses & Dissertations

The development of experimental methodologies for synthesizing a diverse range of metallic and metal oxide nanoparticles tailored for sustainable water treatment applications was investigated. These nanoparticles are prepared using environmentally friendly and scalable synthesis methods, underscoring their potential for large-scale production. Synthesized nanoparticles are harnessed for various processes, including catalysis and electrocatalysis, with a primary objective of degrading and removing organic pollutants from water. Key to this research is the encapsulation of nanoparticles within solid supports. Multiple methodologies are explored to engineer supports that ensure nanoparticle stabilization, monodispersion, and prevent unintended release into the environment. Two alternative approaches were evaluated …

Selective Transfection Of A Transferrin Receptor-Expressing Cell Line With Dna-Lipid Nanoparticles And Synthesis Of Parasite-Derived Glycans As Biomarkers For Leishmaniasis, Irodiel Vinales Lozano

Open Access Theses & Dissertations

Despite notable progress in lipid nanoparticle (LNP)-mediated gene delivery, achieving selective transfection of specific cell types, such as cancer cells, remains a significant hurdle, hindering the advancement of innovative gene therapies. In this study, we engineered an LNP formulation encapsulating plasmid DNA (pDNA) encoding the monomeric Green Lantern (mGL) fluorescent reporter protein. The DT7 peptide ligand targeting human transferrin receptor 1 (hTfR1) was also conjugated to the LNP surface for targeted delivery to hTfR1-expressing cells. Optimization of LNP composition yielded favorable particle diameter, ζ-potential, yield, and pDNA encapsulation efficiency. Evaluation of transfection selectivity using a panel of two engineered cell …

Sulfonated Polyethersulfone Membranes For Electrodialysis Desalination And The Influence Of Solvent Evaporation On Current Efficiency, Salinity Reduction, And Permselectivity, Li Chen

Open Access Theses & Dissertations

The high cost of ion exchange membranes significantly limits the public application of electrodialysis. The research of novel, inexpensive ion exchange membranes is essential to developing and applying electrodialysis desalination technology. This research focuses on fabricating cation exchange membranes with polyethersulfone (PES) and sulfonated PES (sPES) for water treatment. N-Methyl-2-Pyrrolidone (NMP) was used as an organic solvent to dissolve PES. After different solvent evaporation times were optimized from 0 hr to 24 hr, those membranes were formed through the phase inversion technique. The performance results show that the PES membranes performed the best when the solvent evaporated at 3 hr, …

Routing Opportunities For Commercial Crossings Between El Paso And Juarez, Marek Musil

Open Access Theses & Dissertations

This thesis explores the topic of commercial movements between the El Paso and Ciudad Juarez road networks and the implications of the possible changes in their routing. This area houses several ports of entry, which present one of the busiest commercial and personal border crossings in the whole nation. The primary focus was to evaluate the recently proposed reconstruction scenario of removing trucks from the Bridge of the Americas and study the impacts on the flows throughout the other ports. The chosen tool to support the analysis is a mesoscopic simulation software called DynusT, which is capable of modeling the …

Energy Optimization In Pneumatic Systems Using Ens-200 Energy Saving Trainer, Maha Guru Shankar Perumal

Open Access Theses & Dissertations

Various industries such as manufacturing and assembly, the automotive sector, printing and paper handling, packaging, aerospace, etc., widely use pneumatic systems for a variety of operations. Enterprises use pneumatic systems for cost-effectiveness, reliability, and simplicity. However, they also have certain inefficiencies, leading to high operating costs and reduced efficiency in various applications. The focus of this research is on energy optimization in pneumatic systems to improve efficiency in industrial applications, minimize energy waste, and reduce operational costs. The best practices for enhancing energy efficiency in pneumatic systems were proper system design, pressure regulation, leak detection and repair, energy-efficient components, and …

Mav Localization In Gps-Denied Environments And Synthetic Data Collection In Challenging Simulated Conditions, Julio A. Reyes Munoz

Open Access Theses & Dissertations

The development of unmanned aerial systems presents an opportunity for conducting industrial inspections in environments where traditional navigation systems, such as the Global Navigation Satellite System (GNSS), are compromised. This dissertation investigates the implementation of a micro aerial vehicle (MAV) capable of autonomous data acquisition in complex, GNSS-degraded industrial settings. The primary challenge addressed is the robust localization of MAVs, a critical aspect in ensuring reliable operation under varying and uncertain environmental conditions.

The work is divided into two main parts. The first part focuses on the design and integration of a MAV system specifically for power plant inspections in …

Bcl2 Mediated Targeted Drug Delivery For The Treatment Of Kidney Fibrosis And Stomach Cancer, Humayra Afrin

Open Access Theses & Dissertations

Apoptosis, the programmed death of cells, is primarily regulated by a delicate balance between pro-apoptotic and anti-apoptotic signals. The Bcl-2 (B-cell lymphoma 2) family of proteins acts as anti-apoptotic agents, promoting cell survival. Dysregulation of these proteins is a common occurrence in conditions such as cancer and fibrosis, where overexpression of anti-apoptotic members can foster tumor cell survival and fibroblast activation. In this study, our aim was to explore the therapeutic potential of Bcl-2 inhibitors, both as a small molecule (specifically Navitoclax (Navi)), inhibitor and as Bcl-2 siRNA, for targeted treatment. Intravenous administration of Navi often leads to thrombocytopenia, necessitating …

Effect Of Patient Specific Blood Biomarkers On Nanoparticle - Cell Interactions, Veronica Gabriela Contreras

Open Access Theses & Dissertations

Nanoparticles are currently known to be a promising material class for bio-applications in drug delivery and vaccine development. Using gold nanoparticles of varied sizes, in this case 45 and 100 nanometers as a model nanomaterial system, we investigated how patients' blood physiology and chemistry (such as solute, protein, lipid levels) affect the biological response to bionanomaterials. When nanoparticles are injected into the body, biomolecules in the blood adsorb to the nanoparticle's surface to form a biomolecular corona that is specific to the patient's unique blood composition. This biomolecular corona is important because it affects the in vivo fate and biodistribution …

Using Genetic Algorithm And Geographic Information System For Equity-Driven Transportation Planning And Analysis, Emiliano Del Rio Reyes

Open Access Theses & Dissertations

Efforts to address equitable access in public transit planning have gained momentum, spurred by incentives for Metropolitan Planning Organizations (MPOs) and State Departments of Transportation (DOTs). However, traditional strategies often fall short of meeting the needs of disadvantaged communities, particularly in underserved areas. This study presents a pioneering methodology leveraging Genetic Algorithms (GA) and Geographic Information Systems (GIS) to optimize bus stop placement, aiming to enhance equitable access in public transit systems. Focusing on Route 16 of Sun Metro in El Paso, Texasâ??a critical feeder route linking the Westside Transit Center to Upper Valley neighborhoodsâ??the research commences with a comprehensive …

Sports Science: An Entrepreneurial Venture, Nicole J. Jones

Senior Honors Projects

In sports science, ensuring maximum athlete safety and optimizing data utilization are pivotal yet leave room for further work. My project, Unbeaten SafeWare, addresses these critical issues by focusing on two primary concerns: preventing heat-related and cardiac illnesses, which are significant causes of athlete fatalities, and enhancing the transparency and utility of sports data. This initiative involves developing a shirt integrated with sensors to monitor vital signs and an athlete management system to handle data input, storage, analysis, and accessibility for athletes.

The project has advanced through the efforts of a multidisciplinary team, which includes biomedical engineering undergraduates, two faculty …

Evaluation, Rating, And Numerical Modeling Of A Shock Mitigation Seat For High-Speed Craft Based On Laboratory Single Impact Testing, Darren Benn

UNLV Theses, Dissertations, Professional Papers, and Capstones

High-speed craft (HSC) are utilized in military and para-military maneuvers that are usually conducted in harsh environments. The Special Warfare Combatant-craft Crewmen (SWCC), a sub-unit of the United States Naval Special Warfare Command (NAVSOC), use an advanced HSC, known as the Combatant Craft Assault, to conduct coastal patrol and interdiction, and for infiltration and exfiltration of Navy SEALs. The United States Coast Guard, and the Drug Enforcement Agency (DEA), employ HSC for maritime patrol and to pursue ‘go-fast’ boats operated by contraband runners. In most of these intense applications, the mode of operation of the HSC results in planing. Planing …

Removal Of Permethrin And Bifenthrin Insecticides From Runoff Water By Activated Carbon Adsorption, Ernesto Hernandez

UNLV Theses, Dissertations, Professional Papers, and Capstones

Among the hundreds of pesticides and insecticides, pyrethroids-particularly permethrin and bifenthrin, have become very popular due to their high toxicity to insects and low toxicity to humans, leading to extensive use in both agriculture and urban areas. Pyrethroids have no discharge limits because of this, leading to a negative impact on surrounding ecosystems due to their high toxicity to fish and aquatic life. Due to their low solubility and long half-lives, they are prominent in the environment long after application with a high potential for getting transported in runoff water to nearby water bodies. In this study, DSR-C reactivated carbon …

Final Design Of Legion Hall Revitalization In Potter, Nebraska, Madison Brennfoerder

Honors Program: Senior Projects (Public)

This project was conducted to renovate and revitalize the Legion Hall community center in the Village of Potter located in western Nebraska north of the Interstate. The work completed for this project can be separated into five disciplines: Hydrologic & Hydraulic Design, Geotechnical Analysis, Structural Analysis, Environmental Analysis, and Transportation Design. Legion Hall is a historical building within The Village of Potter which was built in 1917. The Village of Potter has recently acquired the rights to the hall and is seeking to revitalize the historical community center to increase tourism in the village.

Detection Of Deficiencies And Data Analysis Of Bridge Members With Deep Convolutional Neural Networks, Bennett Jackson

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Concrete cracks and structural steel corrosion are two of the most common defects in bridges. Quantifying and classifying these defects provide bridge inspectors and engineers with valuable data for assessing deterioration levels. However, the bridge inspection process is typically a subjective, time intensive, and tedious task, as defects can be overlooked or in locations not easily accessible. Previous studies have investigated deep learning-based inspection methods, implementing popular models such as Mask R-CNN and U-Net. The architectures of these models offer certain advantages depending on the required task. This thesis aims to evaluate and compare Mask R-CNN and U-Net regarding their …

Mammary Epithelial Cell Derived Extracellular Vesicles Influence Tumorigenic Phenotype Suppression In Her2-Positive Breast Cancer Cells, Brenda Okereke

All Dissertations

On a global scale, breast cancer remains the most commonly diagnosed cancer in the world. In 2020 alone, there were over 2.3 million new cases of breast cancer seen and a total of 685,000 deaths globally, this represents 16% or 1 in every 6 cancer deaths seen in women. By 2040 it is projected that the breast cancer burden will rise by over 40% to exceed 3 million new cases a year. Further understanding of the underlying biology and mechanisms behind tumor progression and breast cancers such as HER2+ breast cancer would allow for new therapeutic treatment targets to emerge. …

Mesenchymal Stromal Cell Response To Degenerated Intervertebral Disc-Like Ph, Kyle Cannon

All Dissertations

Intervertebral disc degeneration (IVDD) has become increasingly prevalent and is a common contributing factor to low back pain. There are currently no clinical treatment options for IVDD that alleviate the symptoms of IVDD while simultaneously promoting repair of IVD tissue. One treatment option being explored is intradiscal administration of mesenchymal stromal cells (MSCs). However, the microenvironment of the degenerating IVD places significant stress on both native IVD cells and implanted cells. There are several questions that need to be addressed which may help further inform the development of efficacious intradiscal MSC therapies for IVDD. These questions include: 1) Do MSCs …

Identifying Temporomandibular Disorder Morphological Risk Factors Via Explainable Deep Learning And Multiscale Biomechanical Modeling, Shuchun Sun

All Dissertations

Clarifying multifactorial musculoskeletal disorder etiologies supports risk analysis and development of targeted prevention and treatment modalities. Deep learning enables comprehensive risk factor identification through systematic analysis of disease datasets but does not provide sufficient context for mechanistic understanding, limiting clinical applicability for etiological investigations. Conversely, multiscale biomechanical modeling can evaluate mechanistic etiology within the relevant biomechanical and physiological context. We propose a hybrid approach combining 3D explainable deep learning and multiscale biomechanical modeling; we applied this approach to investigate temporomandibular joint (TMJ) disorder etiology by systematically identifying risk factors and elucidating mechanistic relationships between risk factors and TMJ biomechanics and …

Novel Nucleus Pulposus Biomaterial Development And Low Field Mri Assessment For Intervertebral Disc Degeneration, Mario Krussig

All Dissertations

Intervertebral disc degeneration (IVDD) is a prominent pathology in the modern world that causes debilitating pain for many patients. The onset of IVDD occurs in the nucleus pulposus (NP). NP biomaterials will play a vital role in mitigating the progression of IVDD. Within this work, we sought to synthesize a solubilized extracellular matrix (ECM)-based NP biomaterial. Utilizing pepsin or urea extraction, bovine NP ECM was successfully solubilized (SBNPs). SBNP formulations were characterized biochemically, evaluated for cytotoxicity, and down-selected for front-running formulations. Leading candidate SBNPs were incorporated into an alginate bead biomaterial model to determine the potential bioactivity with human adipose-derived …

Robust And Trustworthy Deep Learning: Attacks, Defenses And Designs, Bingyin Zhao

All Dissertations

Deep neural networks (DNNs) have achieved unprecedented success in many fields. However, robustness and trustworthiness have become emerging concerns since DNNs are vulnerable to various attacks and susceptible to data distributional shifts. Attacks such as data poisoning and out-of-distribution scenarios such as natural corruption significantly undermine the performance and robustness of DNNs in model training and inference and impose uncertainty and insecurity on the deployment in real-world applications. Thus, it is crucial to investigate threats and challenges against deep neural networks, develop corresponding countermeasures, and dig into design tactics to secure their safety and reliability. The works investigated in this …