Digital Commons Network^™

Quantifying Variation Across 16s Rrna Gene Sequencing Runs In Human Microbiome Studies, Andrew J. Hoisington, Christopher E. Stamper, Joseph C. Ellis, Christopher A. Lowry, Lisa A. Brenner

Faculty Publications

Recent microbiome research has incorporated a higher number of samples through more participants in a study, longitudinal studies, and metanalysis between studies. Physical limitations in a sequencing machine can result in samples spread across sequencing runs. Here we present the results of sequencing nearly 1000 16S rRNA gene sequences in fecal (stabilized and swab) and oral (swab) samples from multiple human microbiome studies and positive controls that were conducted with identical standard operating procedures. Sequencing was performed in the same center across 18 different runs. The simplified mock community showed limitations in accuracy, while precision (e.g., technical variation) was robust …

E-Scooter Black Box, Soham Phadke, Suvass Ravala, Joshua Jerome, Raghav Batra, Mubashir Hussain

Computer Science and Engineering Senior Theses

The burgeoning market for shared e-scooters is significantly hampered by the short lifespan of commercial e-scooters, which currently average just three months due to rough handling by users. To address this challenge, our project aims to extend the lifespan of shared e-scooters through an innovative onboard solution that discourages detrimental riding behaviors.

Our solution integrates a portable sensor hub from STMicroelectronics to capture ride data, which is then processed and sent via a user’s iOS app to a Google Firebase backend. A machine learning model running in the cloud analyzes the data to extract valuable metrics. These metrics are displayed …

3d Printing Filament Producer: A Reverse 3d Printer, Jackson Mar, Adnesh Tondale, Charles Wallace

Mechanical Engineering Senior Theses

PLA filament stands out as the most widely utilized material in FDM (Fused Deposition Modeling) 3D Printing. This additive manufacturing process involves the layer-by-layer construction of 3D objects, employing a variety of materials. Commonly used materials in 3D printing include PLA, ABS, and PETG plastics, each with unique characteristics suited to specific project requirements. For example, PLA is known for its high tensile strength, while PETG, with its higher melting point, is suitable for applications requiring greater thermal resistance.

Despite the versatility of these materials, the inherent challenge arises with the accumulation of filament waste, comprising supports, benchmark prints, and …

Using Sustainable Technique To Recycle Waste Paper In Academic Institutions, Mustafa M. Mansour

Al-Bahir

It has been clearly demonstrated that it would be feasible to consider recycling paper in an academic institution. This can be achieved through combining specific waste paper baskets, a pulping machine and power supplied by a renewable energy source, with an already established local paper making company. The paper making company would be able to gain a subsidy from the government which pays them to actually recycle paper, to counteract the cost of the pulped paper which is 30% more expensive than raw wood pulp. The academic institution would save money on waste disposal and decrease its carbon footprint by …

Using Discrete-Event Simulation To Balance Staff Allocation And Patient Flow Between Clinic And Surgery In A Pediatric Hospital Setting, John Forbus

Theses and Dissertations

We review the problem of a system-level balanced scheduling scenario. A hospital clinic has a queue for patients needing care. After being seen in clinic, many require follow-up surgery, for which they also wait in a queue. The rate-limiting factor is physician availability for both clinic visits and surgical cases. Much existing work has been done to optimize clinic appointments, as well as to optimize surgical appointments. This novel approach models the entire patient journey at the system level, through both clinic and surgery, to optimize the total patient experience. A discrete-event simulation model of the system is built based …

Mathematical Modeling And Understanding The Physiological Mechanisms Of Vibration On Wound Healing And Scar Remodeling, Devin Rion Needs

Theses and Dissertations

Chronic wounds and pathological scars reduce the quality of life for millions of people worldwide. Through mathematical modeling and clinical testing, understanding of how these conditions occur continues to increase. These tools have also been employed to investigate the efficacy of treatments that could impact wound healing and scar remodeling. The purpose of this work is to investigate the physiological effects of vibration treatment on wound healing, blood flow, and scar remodeling through mathematical modeling and experimental testing. This work presents and validates a mathematical murine model for whole body vibration enhanced wound healing (VEWH). This VEWH model builds on …

Sustainable Sensing With Paper Microfluidics: Applications In Health, Environment, And Food Safety, Sanjay Kumar, Jyoti B. Kaushal, Heow Pueh Lee

Durham School of Architectural Engineering and Construction: Faculty Publications

This manuscript offers a concise overview of paper microfluidics, emphasizing its sustainable sensing applications in healthcare, environmental monitoring, and food safety. Researchers have developed innovative sensing platforms for detecting pathogens, pollutants, and contaminants by leveraging the paper’s unique properties, such as biodegradability and affordability. These portable, low-cost sensors facilitate rapid diagnostics and on-site analysis, making them invaluable tools for resource-limited settings. This review discusses the fabrication techniques, principles, and applications of paper microfluidics, showcasing its potential to address pressing challenges and enhance human health and environmental sustainability.

Implications Of The Covid-19 Pandemic On The Management Of Municipal Solid Waste And Medical Waste: A Comparative Review Of Selected Countries, Ahmed Osama Daoud Dr., Hoda Elattar Eng., Gaber Abdelatif Eng., Karim M. Morsy, Robert W. Peters, Mohamed K. Mostafa Dr.

Civil Engineering

No abstract provided.

Utilizing Waste Rocks From Phosphate Mining In Jordan As Concrete Aggregates, Tamer Eljufout, Fadi Alhomaidat

Open Initiatives Grant Funded Publications-Archive

This study investigates the potential of replacing natural aggregates in concrete with aggregates obtained from Phosphate Mine Waste (PMW) rocks in Jordan. Several tests were conducted to determine the PMW rocks’ chemical, physical, and mechanical properties according to ASTM standards. A comprehensive experimental investigation was conducted, involving thirty-six concrete cylinder specimens, to evaluate the strength and durability properties of concrete made with PMW rocks compared to concrete made with natural limestone aggregates. The tested aggregates of PMW rocks consist mainly of quartz, dolomite, montmorillonite, and flu- orapatite. Their physical and mechanical properties were found to be similar to the natural …

Autonomous Image-Based Corrosion Detection In Steel Structures Using Deep Learning, Amrita Das, Sattar Dorafshan, Naima Kaabouch

Civil Engineering Faculty Publications

Steel structures are susceptible to corrosion due to their exposure to the environment. Currently used non-destructive techniques require inspector involvement. Inaccessibility of the defective part may lead to unnoticed corrosion, allowing the corrosion to propagate and cause catastrophic structural failure over time. Autonomous corrosion detection is essential for mitigating these problems. This study investigated the effect of the type of encoder–decoder neural network and the training strategy that works the best to automate the segmentation of corroded pixels in visual images. Models using pre-trained DesnseNet121 and EfficientNetB7 backbones yielded 96.78% and 98.5% average pixel-level accuracy, respectively. Deeper EffiecientNetB7 performed the …

Do You Know Where Your Games Come From? Artificial Intelligence And Game Development, Andrew Begemann

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

ABSTRACT

This paper was written to explore the possible effects of artificial intelligence being implemented in the design pipeline of video game development. In it, we will explore a history of artificial intelligence, from its early imaginings in books and philosophy, to its current iterations, such as ChatGPT and other popular engines like Midjourney and Stable diffusion. We will also discuss steps in game development so as to understand where the potential implementations of artificial intelligence can, will, or does occur. Following those explanations, we will explore the three methodologies of Marxism, Psychoanalysis, and Cultural Studies as ways of examining …

Embracing The Irreplaceable: The Role Of Neurodiversity In Cultivating Human-Ai Symbiosis In Education, Piper Hutson

International Journal of Emerging and Disruptive Innovation in Education : VISIONARIUM

This study investigates the indispensable role of human skills—such as empathy, ethical judgment, and nuanced understanding—in the development and application of artificial intelligence (AI) within higher education, highlighting the unique contributions of neurodivergent perspectives in creating a symbiotic human-AI relationship. Drawing upon research that evidences the superior performance of diverse teams in creativity and innovation, the paper argues for the integration of neurodiversity into AI development as a means to address the philosophy of 'fearing the Other,' thereby mitigating biases and fostering ethical AI interactions. The technology sector's adoption of Diversity, Equity, and Inclusion (DEI) programs, including biopsychosocial interventions and …

Highly Comparative Time Series Analysis Of Oxygen Saturation And Heart Rate To Predict Respiratory Outcomes In Extremely Preterm Infants, Jiaxing Qui, Juliann M. Di Fiore, Narayanan Krishnamurthi, Premananda Indic, Additional Authors, Prematurity-Related Ventilatory Control (Pre-Vent) Investigators

Electrical Engineering Faculty Publications and Presentations

Objective. Highly comparative time series analysis (HCTSA) is a novel approach involving massive feature extraction using publicly available code from many disciplines. The Prematurity-Related Ventilatory Control (Pre-Vent) observational multicenter prospective study collected bedside monitor data from > 700 extremely preterm infants to identify physiologic features that predict respiratory outcomes. Approach. We calculated a subset of 33 HCTSA features on > 7 M 10 min windows of oxygen saturation (SPO2) and heart rate (HR) from the Pre-Vent cohort to quantify predictive performance. This subset included representatives previously identified using unsupervised clustering on > 3500 HCTSA algorithms. We hypothesized that the best HCTSA algorithms would …

06.03.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Center for Population Studies, NSF Postdoc Berg, Quinn Appointed to HEPAP, Smitherman migraine research

A Study On The Effects Of Cementless Total Knee Arthroplasty Implants’ Surface Morphology Via Finite Element Analysis, Scott Hazelwood, Peter J. Hunt, Mohammad Noori, Naudereh B. Noori, Wael A. Altabey

Biomedical Engineering

Total knee arthroplasty (TKA) is one of the most commonly performed orthopedic surgeries, with nearly one million performed in 2020 in the United States alone. Changing patient demographics, predominately indicated by increases in younger, more active, and more obese patients undergoing TKA, poses a challenge to orthopedic surgeons as these factors present a greater risk of long-term complications. Historically, cemented TKA has been the gold standard for fixation, but long-term aseptic loosening continues to be a risk for cemented implants. Cementless TKA, which relies on the surface morphology of a porous coating for biologic fixation of implant to bone, may …

Noninvasive Technique For Measuring Cardiac Output, Grace E. Kolar, Rachel Simonton, Eli Strohecker

Williams Honors College, Honors Research Projects

NA

Single-Molecule Orientation Imaging Reveals The Nano-Architecture Of Amyloid Fibrils Undergoing Growth And Decay, Brian Sun, Tianben Ding, Weiyan Zhou, Tara S. Porter, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Amyloid-beta (Aβ42) aggregates are characteristic Alzheimer’s disease signatures, but probing how their nanoscale architectures influence their growth and decay remains challenging using current technologies. Here, we apply time-lapse single-molecule orientation-localization microscopy (SMOLM) to measure the orientations and rotational “wobble” of Nile blue (NB) molecules transiently binding to Aβ42 fibrils. We correlate fibril architectures measured by SMOLM with their growth and decay over the course of 5 to 20 min visualized by single-molecule localization microscopy (SMLM). We discover that stable Aβ42 fibrils tend to be well-ordered and signified by well-aligned NB orientations and small wobble. SMOLM also shows that increasing order …

Study Of Factors Influencing Traffic Violations In Jakarta: Perspective Of The Theory Of Planned Behavior (Tpb) In The Implementation Of Electronic Traffic Law Enforcement (Etle), Khobat Dewa Ruci, Sutanto Soehodho, R. Jachrizal Sumabrata

Smart City

Transportation safety in Indonesia reflects its culture and modernity, but the high rate of traffic accidents indicates significant challenges. Data from IRSMS and Polda Metro Jaya reveal an increase in accidents and traffic violations, reinforcing the need for effective law enforcement. The implementation of ETLE, supported by Law No. 22 of 2009 on Road Traffic and Transportation and Law No. 19 of 2016 on Electronic Information and Transactions, is a strategic effort to improve law enforcement. However, its effectiveness in Jakarta context still requires in-depth evaluation. This thesis focuses on the psychological factors in the use of ETLE using the …

Evaluating Visual Dependence In Postural Stability Using Smartphone And Stroboscopic Glasses, Brent A. Harper, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

This study explores the efficacy of integrating stroboscopic glasses with smartphone-based applications to evaluate postural control, offering a cost-effective alternative to traditional forceplate technology. Athletes, particularly those with visual and visuo-oculomotor enhancements due to sports, often suffer from injuries that necessitate reliance on visual inputs for balance—conditions that can be simulated and studied using visual perturbation methods such as stroboscopic glasses. These glasses intermittently occlude vision, mimicking visual impairments that are crucial in assessing dependency on visual information for postural stability. Participants performed these tasks under three visual conditions: full vision, partial vision occlusion via stroboscopic glasses, and no vision …

Sustaining Digital Assets Through Mobile Estate Planning, Norliza Katuk, Asvinitha Muniandy, Norazlina Abd. Wahab, Ijaz Ahmad

An-Najah University Journal for Research - B (Humanities)

Many people own online accounts, with some having financial values like Internet banking, e-wallet and cryptocurrency. In the case of sudden death, their heirs are unaware of the digital assets possessed by the deceased person, which causes the assets to be lost forever, and the heirs might not receive the assets. If an estate plan did not account for digital assets properly, the beneficiaries would not be able to access them. Therefore, this paper addresses this issue by implementing a software development approach in designing a suitable model for sustaining digital assets through smartphones to allow the inheritance of digital …

Prototype Device For Measuring The Dustiness Of Stone And Lime Dust Used In Explosion Prevention, Adrian Toman, Zdzisław Dyduch, Tomasz Skowronek

Journal of Sustainable Mining

This paper presents the prototype of a device for measuring the dustiness of powdered materials by means of a new measurement method. The currently employed stationary laboratory device, utilised in KD “Barbara”, uses the attenuation of a radiant flux transmitted through a dust cloud induced by a manually generated air blast. The new device uses the same measurement method, but it includes modern elements based on a microprocessor, a laser line generator instead of an LED diode, and a precise multi-channel detector. The generated quantity of the mixture (dust and air) is strictly determined and precisely dosed via buffer containers, …

Tracking Mining Company Electric Vehicles For Sustainable Development Optimization Using Distributed Ledger Technologies, Teodora Hristova

Journal of Sustainable Mining

It is established that based on the industrial revolutions towards Industry 5.0, the population of the Earth and its well-being are increasing. To preserve and improve living conditions the development in all spheres of life is by the paradigm of sustainable development. Through the prism of the mining industry, one step could be the introduction of circular economy measures for digitized tracking of materials, repairs, consumed electricity, safety, and finances. Implementing of electric cars is an option to achieve this goal through automation, manageability, and data traceability via Industry 4.0 technologies. Such are blockchain technologies, IoT, V2V, and others. For …

Waypoint Profiler, Jeff Ke, Ricky Schober, Alexander Collins, Kevin Wang

Computer Science and Engineering Senior Theses

Ocean health monitoring is crucial for maintaining the health of the ocean ecosystem. Currently, divers are deployed to collect data manually, which is both time and resource-consuming. Additionally, this process poses significant dangers to the divers. Therefore, a more efficient method for collecting oceanic data is needed. This thesis describes the design of a novel autonomous marine vehicle, the waypoint profiler. Launched from shore with scientific sensors, it autonomously navigates to ocean locations of interest and dives to measure key ocean health markers. The system integrates subsystems for scientific sensing, health monitoring, structural integrity, communications, and navigation/control, tailored to meet …

Development Of An Advanced Step Counting Algorithm With Integrated Activity Detection For Free Living Environments, Paige M. Dolan

Master's Theses

Physical activity plays a crucial role in maintaining overall health and reducing the risk of various chronic diseases. Step counting has emerged as a popular method for assessing physical activity levels, given its simplicity and ease of use. However, accurately measuring step counts in free-living environments presents significant challenges, with most activity trackers exhibiting a percent error above 20%. This study aims to address these challenges by creating a machine learning algorithm that leverages activity labels to improve step count accuracy in real-world conditions. Two approaches to balancing data were used: one employed a simpler oversampling technique, while the other …

Engineering An Injectable Hydrogel With Self-Assembling 3d Vasculature, Kendyl Cohn

Master's Theses

This research developed methods for culturing self-assembling capillaries in an injectable gel as a potential method for vascularizing tissue-on-a-chip models to mimic physiological drug delivery. Additionally, a mathematical model was developed as a tool for understanding nutrient delivery and comparison of potential delivery systems. Organs-on-a-chip provide novel platforms for studying biology and physiology in 3D, allow exploration of tissue engineering on a manageable scale, and serve as models for drug screening and drug-delivery testing.

Methods were first developed for co-culture of endothelial cells and fibroblasts (3T3s or HDFs) in 2D, evaluating culture time, seeding density and ratio of HUVECs and …

Thermal Preconditioning Effects On Perforation Propensity Of Transvenous Implantable Cardiac Leads Used For Pacing And Defibrillation, Diane Muff

Master's Theses

Thermal preconditioning to simulate shipping, handling and storage conditions did not affect distal tip stiffness values for permanently implantable cardiac leads used for pacing and defibrillation. Leads that were subjected to extreme temperatures and temperature cycling did not show changes in buckle force values compared with control specimens which were maintained at ambient room conditions. Absolute differences between all measurements were small, generally under 0.05 N and were attributable to measurement variability.

Buckle force values are used to assess the propensity of leads to perforate the heart, a rare but potentially serious complication of implantable pacing and defibrillation systems. Since …

In-Vitro Hydrogel Blood Clots, Ethan Evans, Khoi-Austin Ngo

Bioengineering Senior Theses

Creating a sustainable, ethical, and affordable substitute for animal blood in balloon catheter testing for Deep Vein Thrombosis (DVT) is important to take into consideration. This research utilizes agarose and dextran to develop hydrogel-based artificial blood clots. These hydro gels replicate the mechanical characteristics of human thrombi across acute, subacute, and chronic stages through their elastic and viscous moduli (G' and G") and phase angles. This project addresses extant testing protocols, including temperature regulation, agarose processing, and well plate size, and suggests efficient approaches to encounter these problems.

The hydrogels were characterized by means of a thorough literature review and …

Packed-Bed Reactor For Integrated Peritoneal Dialysis, Julia Appleget, Ally Kwong, Megan Moglia

Bioengineering Senior Theses

Patients with chronic kidney disease (CKD) have lost kidney function. 800,000 Americans have end-stage kidney disease resulting in one of the leading causes of mortality cross-listed with diabetes and heart disease. Over the past decade, the percentage of patients using peritoneal dialysis (PD) has nearly doubled. PD which is a portable treatment involves the insertion of a catheter into the selectively permeable peritoneal cavity infused with a hyperosmolar dialysis fluid drawing the toxins from capillary beds of the peritoneum and into a gravity fed waste solution with a reported clearance of 87%. In order to improve the clearance of the …

Fire Protection And Life Safety Analysis Of The Carlsbad Village Lofts, Nathaniel Cheung

Fire Protection Engineering: Culminating Experience Project Reports

This culminating project has been submitted as part of the graduate program in Fire Protection Engineering at Cal Poly. The building is a 221,000 square feet mixed-use residential apartment building comprising of 106 units. The report is split into two sections. The prescriptive based analysis considers the building’s compliance with the requirements found in the 2016 California Building and Fire Codes. The performance based section evaluated design fires to verify that the final building design and operating procedures met the life safety needs of its occupants.

The prescriptive based analysis was split into four main parts. The four parts were …

Fire & Life Safety Evaluation Of The Goff Health Sciences And Technology Building, Philip Bond

Fire Protection Engineering: Culminating Experience Project Reports

The purpose of this report is to practically apply the information conveyed in the Cal Poly Fire Protection Engineering Master of Science program by selecting a building and analyzing prescriptive and performance-based design features that accomplish the building’s life safety strategy. The selected building is the Goff Health Sciences and Technology Building located in Oak Ridge, Tennessee.

The Goff Health Sciences and Technology Building is a three-story educational facility with business, education, and assembly occupancies. The fire safety strategy of the building depends on a fire alarm communication system, wet pipe sprinkler system, structural fire protection components, and egress elements …