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Point-Of-Care Immunoassay System Using Carbon Nanotube Labels, Adeyabeba Abera

LSU Doctoral Dissertations

The goal of this research was to develop enhanced signal detection mechanisms for immunosensing using carbon nanotubes (CNTs). The utilization of CNT labels for direct electrical measurement was implemented on lateral flow system and microfluidic integrated interdigitated array microelectrodes. These sensing mechanisms in simple and miniaturized system provided higher sensitivity and autonomous flow control for rapid detection aimed at point-of-care diagnostics. Specific functionalization protocols were carried out to chemically modify the surface of the CNTs for uniform dispersion and antibody conjugation in aqueous solution. Surfactant assisted dispersion of the CNTs was studied using PVP and PEG. Covalent conjugation of antibodies …

Antioxidant Nanoparticles As Delivery Systems, Carlos Ernesto Astete R.

LSU Doctoral Dissertations

The goal of the study was to develop antioxidant polymeric nanoparticles as a new delivery system for food and pharmaceutical applications. Natural antioxidants like alpha-tocopherol, vitamin C, and carnosine, are responsible to protect biological systems against free radicals attack. The conjugation of vitamin C-vitamin E (EC) and alpha-tocopherol-carnosine (VECAR) were performed to obtain antioxidant surfactants which were used for polymeric nanoparticle synthesis. The surfactant made of á-tocopherol (vitamin E) and ascorbic acid (vitamin C) of antioxidant properties dubbed as EC was used to make poly(lactic-co-glycolic) acid (PLGA) nanoparticles. Self-assembled EC nanostructures and PLGA-EC nanoparticles were made by nanoprecipitation, and the …

Value-Added Processing Of Rice And Rice By-Products, Rebecca C. Schramm

LSU Doctoral Dissertations

World competition has encouraged United States rice farmers and rice mills to be efficient in farming and production practices. Efforts to augment economic competitiveness include development of new varieties, improvements in milling practices, and identification of uses for rice products and by-products. The research detailed in this dissertation adds to the body of knowledge in milling practices and identification of uses for rice bran. To improve the prediction of milled rice quality at industrial scale, correlations for milling quality among laboratory, pilot, and industrial scale mills were identified for Clearfield 161. Final industrial product whiteness was ten points higher than …

Structural Health Monitoring With Piezoelectric Wafer Active Sensors—Predictive Modeling And Simulation, Victor Giurgiutiu

Faculty Publications

This paper starts a review of the state of the art in structural health monitoring with piezoelectric wafer active sensors and follows with highlighting the limitations of the current approaches which are predominantly experimental. Subsequently, the paper examines the needs for developing a predictive modeling methodology that would allow to perform extensive parameter studies to determine the sensing method’s sensitivity to damage and insensitivity to confounding factors such as environmental changes, vibrations, and structural manufacturing variability. The thesis is made that such a predictive methodology should be multi-scale and multi-domain, thus encompassing the modeling of structure, sensors, electronics, and power …

Structural Health Monitoring With Piezoelectric Wafer Active Sensors--Predictive Modeling And Simulation, Victor Giurgiutiu

Faculty Publications

This paper starts a review of the state of the art in structural health monitoring with piezoelectric wafer active sensors and follows with highlighting the limitations of the current approaches which are predominantly experimental. Subsequently, the paper examines the needs for developing a predictive modeling methodology that would allow to perform extensive parameter studies to determine the sensing method’s sensitivity to damage and insensitivity to confounding factors such as environmental changes, vibrations, and structural manufacturing variability. The thesis is made that such a predictive methodology should be multi-scale and multi-domain, thus encompassing the modeling of structure, sensors, electronics, and power …

Exploration Of The Role Of Serum Factors In Maintaining Bone Mass During Hibernation In Black Bears, Rachel Marie Bradford

Dissertations, Master's Theses and Master's Reports - Open

Disuse osteoporosis is a condition in which reduced mechanical loading (e.g. bed-rest, immobilization, or paralysis) results in unbalanced bone turnover. The American black bear is a unique, naturally occurring model for the prevention of disuse osteoporosis. Bears remain mostly inactive for up to half a year of hibernation annually, yet they do not lose bone mechanical strength or structural properties throughout hibernation. The long-term goal of this study is to determine the biological mechanism through which bears maintain bone during hibernation. This mechanism could pinpoint new signaling pathway targets for the development of drugs for osteoporosis prevention. In this study, …

Building Support For Coud Computing In The Irish Construction Industry, Alan Redmond, Alan V. Hore, Roger West

Conference papers

The construction industry has been traditionally recognised as a fragmented sector associated with a poor level of implementation and penetration of Information Communication Technology (ICT) by Small to Medium Size Enterprises (SMEs). Cloud computing is a collective term that can facilitate the ability to collaborate within a central repository that can act as a base for interoperability between various construction disciplines and their software applications. Cloud computing is a new layer of internet architecture that creates an open opportunity to add better functionality to an increasingly global network. The characteristics of cloud computing, such as, shared infrastructure, on-demand applications, elasticity …

Tapping Environmental History To Recreate America’S Colonial Hydrology, Christopher L. Pastore, Mark B. Green, Daniel J. Bain, Andrea Muñoz-Hernandez, Charles J. Vörösmarty, Jennifer Arrigo, Sara Brandt, Jonathan M. Duncan, Francesca Greco, Hyojin Kim, Sanjiv Kumar, Michael Lally, Anthony J. Parolari, Brian Pellerin, Nira Salant, Adam Schlosser, Kate Zalzal

Civil and Environmental Engineering Faculty Research and Publications

To properly remediate, improve, or predict how hydrological systems behave, it is vital to establish their histories. However, modern-style records, assembled from instrumental data and remote sensing platforms, hardly exist back more than a few decades. As centuries of data is preferable given multidecadal fluxes of both meteorology/climatology and demographics, building such a history requires resources traditionally considered only useful in the social sciences and humanities. In this Feature, Pastore et al. discuss how they have undertaken the synthesis of historical records and modern techniques to understand the hydrology of the Northeastern U.S. from Colonial times to modern day. Such …

Individualized Cognitive Modeling For Close-Loop Task Mitigation, Guangfan Zhang, Roger Xu, Wei Wang, Jiang Li, Tom Schnell, Mike Keller, Thomas E. Pinelli (Ed.)

Electrical & Computer Engineering Faculty Publications

An accurate real-time operator functional state assessment makes it possible to perform task management, minimize risks, and improve mission performance. In this paper, we discuss the development of an individualized operator functional state assessment model that identifies states likely leading to operational errors. To address large individual variations, we use two different approaches to build a model for each individual using its data as well as data from subjects with similar responses. If a subject's response is similar to that of the individual of interest in a specific functional state, all the training data from this subject will be used …

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

Residential Energy Monitoring: Missouri S&T Solar Village Development, Christopher David Wright

Masters Theses

"As energy costs are rising, public and private sector groups are searching for improved energy efficiency technology. Research tools for predicting residential energy usage are lagging behind commercial developments. Missouri S&T has a unique and strong opportunity to strengthen its involvement in the development of residential energy research and knowledge. The S&T Solar Village, a collection of homes designed for energy efficiency and renewable energy, is poised to support this research. This thesis develops a design for residential energy evaluation and data collection of the four solar homes in the Village. The energy evaluation system identifies over 300 sensors and …

Incorporating New Technology Into Healthcare: An Analysis Of Performance, Acceptance, And Safety, Anthony Joseph Strawhun

Masters Theses

"Each year, advances in the healthcare industry allows for better patient care and increased ability to save lives. Looking at standardized and common healthcare devices for both inside and outside the hospital environment, this research studied the tradeoffs and human factors that affect operator performance and patient survival. This research studied the impact of human factors and technology in the development and implementation of the automated external defibrillator for out-of-hospital use and the incremental advantages of SMArT infusion pump technology over traditional intravenous infusion pumps for in-hospital care. The study highlights the complex human factors of both products and establishes …

Adaptive User Interface For Vehicle Swarm Control, Paul Robinette

Masters Theses

"An algorithm to automatically generate behaviors for robotic vehicles has been created and tested in a laboratory setting. This system is designed to be applied in situations where a large number of robotic vehicles must be controlled by a single operator. The system learns what behaviors the operator typically issues and offers these behaviors to the operator in future missions. This algorithm uses the symbolic clustering method Gram-ART to generate these behaviors. Gram-ART has been shown to be successful at clustering such standard symbolic problems as the mushroom dataset and the Unix commands dataset. The algorithm was tested by having …

Development Of A Contingency Capillary Wastewater Management Device, Evan A. Thomas

Mechanical and Materials Engineering Faculty Publications and Presentations

The personal body-attached liquid liquidator (PBALL) is conceived as a passive, capillary-driven, contingency wastewater disposal device. In this contingency scenario, the airflow system on the NASA crew exploration vehicle is assumed to have failed, leaving only passive hardware and vacuum vent to dispose of wastewater. To meet these needs, the PBALL was conceived to rely on capillary action and urine wetting conditions from 0° < θadv ∼ 90°, be adaptable for both male and female use, collect and retain up to 1 L of urine, minimize splash-back, and allow continuous draining of the wastewater to vacuum while minimizing cabin air loss. A subscale PBALL test article, which was tested on NASA's reduced-gravity aircraft in April 2010, successfully demonstrated key components of this design.

Climate And More Sustainable Cities: Climate Information For Improved Planning And Management Of Cities (Producers/Capabilities Perspective), C.S.B. Grimmond, Matthias Roth, Tim R. Oke, Y. C. Au, M. Best, R. Betts, Gregory R. Carmichael, Helen Cleugh, Walter F. Dabberdt, Rohinton Emmanuel, E. Freitas, K. Fortuniak, Steven Hanna, Petra M. Klein, Laurence S. Kalkstein, C. H. Liu, Alex Nickson, David Pearlmutter, David J. Sailor, James Voogt

Mechanical and Materials Engineering Faculty Publications and Presentations

In the last two decades substantial advances have been made in the understanding of the scientific basis of urban climates. These are reviewed here with attention to sustainability of cities, applications that use climate information, and scientific understanding in relation to measurements and modelling. Consideration is given from street (micro) scale to neighbourhood (local) to city and region (meso) scale. Those areas where improvements are needed in the next decade to ensure more sustainable cities are identified. High-priority recommendations are made in the following six strategic areas: observations, data, understanding, modelling, tools and education. These include the need for more …

Posture Systematically Alters Ear-Canal Reflectance And Dpoae Properties, Susan E. Voss, Modupe F. Adegoke, Nicholas J. Horton, Kevin N. Sheth, Jonathan Rosand, Christopher A. Shera

Engineering: Faculty Publications

Several studies have demonstrated that the auditory system is sensitive to changes in posture, presumably through changes in intracranial pressure (ICP) that in turn alter the intracochlear pressure, which affects the stiffness of the middle-ear system. This observation has led to efforts to develop an ear-canal based noninvasive diagnostic measure for monitoring ICP, which is currently monitored invasively via access through the skull or spine. Here, we demonstrate the effects of postural changes, and presumably ICP changes, on distortion product otoacoustic emissions (DPOAE) magnitude, DPOAE angle, and power reflectance. Measurements were made on 12 normal-hearing subjects in two postural positions: …

The Relationship Between Information Technology And Construction Productivity, Dong Zhai

University of Kentucky Doctoral Dissertations

Over the past decades, information technology has been impacting industries, economics, the way of life and even the culture throughout the world. Productivity has been attracting much attention as an important indicator of economics, and numerous researchers have investigated the relationship between information technology and productivity. Construction is one of the largest industries in the United States, but little research has been conducted to investigate the relationship between information technology and construction productivity.

The major objective of this dissertation is to determine the degree (if any) to which information technology usage, specifically the use of information technology to automate and …

Integration Of The Regression-Based Land Use Model And The Combined Trip Distribution-Assignment Transportation Model, Meiwu An

University of Kentucky Doctoral Dissertations

Regional growth caused the emergence of traffic congestion and pollution in the past few decades, which have started to affect small urban areas. These problems are not only related to transportation system design but also to land use planning. There has been growing recognition that the relationship between land use and transportation needs to be understood and analyzed in a consistent and systematic way. Integrated urban models have recently been introduced and implemented in several metropolitan areas to systematically examine the relationship between land use and transportation. The general consensus in the field of integrated urban models is that each …

Arsenite Oxidation By Pure Cultures Of Thiomonas Arsenivorans Strain B6 In Bioreactor Systems, Aniruddha Dastidar

University of Kentucky Doctoral Dissertations

The removal of arsenic toxicity from water is accomplished by a preliminary preoxidative step transforming the most toxic form, arsenite (As (III)), to the least toxic form, arsenate (As (V)). The potential of As (III) oxidation to As (V) was initially investigated in batch reactors using the chemoautotrophic Thiomonas arsenivorans strain b6 under varying initial As (III) and cell concentrations and at optimal pH and temperature conditions (pH 6.0 and temperature 30°C). The strain b6 completely oxidized As (III) to As (V) during exponential growth phase for lower levels of As (III) concentrations (≤ 100 mg/L) but continued into stationary …

Remote Controlled Hydrogel Nanocomposites: Synthesis, Characterization, And Applications, Nitin S. Satarkar

University of Kentucky Doctoral Dissertations

There is significant interest in the development of hydrogels and hydrogel nanocomposites for a variety of biomedical applications including drug delivery, sensors and actuators, and hyperthermia cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled (RC) actuation. In this dissertation, the development of hydrogel nanocomposites containing magnetic nanoparticles/carbon nanotubes, actuation with remote stimulus, and some of their applications are highlighted.

The primary hydrogel nanocomposite systems were synthesized by incorporation of magnetic nanoparticles into temperature responsive N-isopropylacrylamide (NIPAAm) matrices. Various nanocomposite properties …

Engineering Sport Safety: A Study Of Equestrian Cross Country Eventing, Katherine M. Kahmann

University of Kentucky Master's Theses

The sport of equestrian cross country eventing has seen many serious and even fatal injuries due to rotational horse falls in recent years. The sport originally consisted of horse and rider teams jumping stationary, wood fences. However, in a move towards increasing safety for horses and riders, frangible and deformable safety devices have been emerging in the field. This thesis provides an overview of safety designs that are currently available and those that are on the horizon. Also, a path-finder method of evaluating and developing safety fence designs was outlined and applied to two distinct designs, a hinged gate and …

Sustainable Resource Utilization In Manufacturing Of Printed Circuit Board Assembly: Exergy Analysis Of The Process, Subramaniam Saiganesh

University of Kentucky Master's Theses

Engineering for sustainable development requires prudent utilization of resources under economic, environmental and societal constraints. Resource utilization must follow a holistic approach. This brings in a need for comprehensive metrics which are simple, standard and universal. Thermodynamics may offer a metric that focuses on both quality and quantity of energy resources which may carry information to be combined with other metrics. This metric may be a thermodynamic property called exergy or available energy, which provides a better insight into resource use in both energy and non-energy producing systems. This thesis is devoted to a study of the exergy concept in …

Investigating An Optimal Decision Point For Probability Bounds Analysis Models When Used To Estimate Remedial Soil Volumes Under Uncertainty At Hazardous Waste Sites, Charles O. Dankwah

Walden Dissertations and Doctoral Studies

Hazardous waste site remediation cost estimation requires a good estimate of the contaminated soil volume. The United States Environmental Protection Agency (U.S. EPA) currently uses deterministic point values to estimate soil volumes but the literature suggests that probability bounds analysis (PBA) is the more accurate method to make estimates under uncertainty. The underlying statistical theory is that they are more accurate than deterministic estimates because probabilistic estimates account for data uncertainties. However, the literature does not address the problem of selecting an optimal decision point from the interval-valued PBA estimates. The purpose of this study was to identify the optimal …

Manual Handling Workload And Musculoskeletal Discomfort Among Warehouse Personnel, Terrance N. Knox

Walden Dissertations and Doctoral Studies

Work-related musculoskeletal disorders (WRMSD), specifically physical and muscular discomfort in the upper arm, lower arm, thigh, lower leg, wrist, shoulders, back, or neck, are among the most frequently reported workplace injuries in the United States. The dearth of knowledge about the types of workloads that may contribute to the development of WRMSD was the impetus of this research. The study aimed to identify antecedents of WRMSD among warehouse workers in order to reduce WRMSDs and increase productivity as expressed in a systems perspective on industrial health. The research questions examined the prevalence of specific WRMSDs, the relationship of high-risk tasks …

Modelling The Impact Of Urbanization On Groundwater Using System Dynamic Technique. A Case Study Of Arusha Municipal Well Field In Northeastern Tanzania, Nimzihirwa Kashimbiri

Tanzania Journal of Engineering and Technology (TJET)

This paper is concerned with the impact of urbanization in aquifer well-system located in the Municipal area of Arusha city, Tanzania. A system dynamic (SD) model was built under VENSIM PLE workbench from twenty-five years (1978-2003) physical and non-physical data to simulate their interactions and relations. This involved use of mathematics ideas and concepts in studying the physical and non – physical components separately, and finally putting them together in new form (model) and study their relations. After model was found to be structurally complete and simulate properly by using the model and unit check tool of VENSIMPLE, parametric calibration …

Real-Time Modeling Of Distributed Plug-In Vehicles For V2g Transactions, Ganesh K. Venayagamoorthy, Pinaki Mitra, Keith Corzine, Chris Huston

Electrical and Computer Engineering Faculty Research & Creative Works

A real-time model of a fleet of plug-in vehicles performing vehicle-to-grid (V2G) power transactions is presented in this paper. Two sets of four vehicles are connected to both the grid and to each other through a short transmission line. the real-time modeling is carried out on a Real-Time Digital Simulator (RTDS). This setup allows for two different case studies with either two distributed sets of four individual vehicles or two smart parking lots with several vehicles. Output power levels and charge/discharge times are scheduled intelligently in order to maximize profits from grid transactions based on one-day ahead electricity pricing. the …

Structural Identification Using A Low-Cost Search Method, James W. Fonda, Steve Eugene Watkins

Electrical and Computer Engineering Faculty Research & Creative Works

An easily implementable and trainable damage detection method is proposed and implemented for a simple truss structure. The approach uses the iterative search identification method and is compatible with low-cost and low-power microcontroller hardware. This method employs pattern matching for a data set from a strain sensor array and predicts location (truss member) and severity (member cross sectional area) of damage. As a health monitoring approach, the method is not as robust or rigorous as more complex methods. However, it has modest processing requirements and can handle noisy signals. The work presents an algorithm applied to a truss structure, the …

One Million Plug-In Electric Vehicles On The Road By 2015, Ahmed Yousuf Saber, Ganesh K. Venayagamoorthy

Electrical and Computer Engineering Faculty Research & Creative Works

It is mentioned that one million plug-in hybrid and electric vehicles will be on the road by 2015 in United States to reduce emission. If one million electric vehicles (EVs) are connected to the existing electric grid randomly, peak load will be very high. Electrified transportation based on a traditional thermal power system will be costly economically and environmentally though it has a great value for electric power and transportation sectors. EVs cannot alone solve the emission problem completely since they need electric power, which is one of the main sources of emission. Therefore, significant emission reduction greatly depends on …

The Antimicrobial Triclocarban Stimulates Embryo Production In The Freshwater Mudsnail Potamopyrgus Antipodarum, Ben D. Giudice, Thomas M. Young

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Recent research has indicated that the antimicrobial chemical triclocarban (TCC) represents a new type of endocrine disruptor, amplifying the transcriptional activity of steroid hormones and their receptors while itself exhibiting little affinity for these receptors. The effects of TCC were studied in the freshwater mudsnail Potamopyrgus antipodarum. Specimens were exposed to concentrations ranging from 0.05 to 10.5 mg/L dissolved TCC and were removed and dissected, and embryos contained within the brood pouch were counted and classified as shelled or unshelled after two and four weeks of exposure. After four weeks, environmentally relevant TCC concentrations of 1.6 to 10.5 mg/L resulted …

Applied Climate-Change Analysis: The Climate Wizard Tool, Evan H. Girvetz, Chris Zganjar, George T. Raber, Edwin P. Maurer, Peter Kareiva, Joshua J. Lawler

Civil, Environmental and Sustainable Engineering

Background: Although the message of ‘‘global climate change’’ is catalyzing international action, it is local and regional changes that directly affect people and ecosystems and are of immediate concern to scientists, managers, and policy makers. A major barrier preventing informed climate-change adaptation planning is the difficulty accessing, analyzing, and interpreting climate-change information. To address this problem, we developed a powerful, yet easy to use, web-based tool called Climate Wizard (http://ClimateWizard.org) that provides non-climate specialists with simple analyses and innovative graphical depictions for conveying how climate has and is projected to change within specific geographic areas throughout the world. Methodology/Principal Findings: …