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Synthesis And Analytical Evaluation Of Folate Conjugates For Use In Cancer Cell Detection, Sneha Reddy Kuthuru

All Capstone Projects

Recent clinical studies have shown the importance of folate receptor in drug delivery system as they increase the potency and reduce toxicity of many cancer therapies. The folate receptor alpha ( FR-a) binds with high affinity for folic acid and serves for receptor mediated transport of folate into cells. Folate is necessary for DNA metabolism and thus it is speculated that rapidly dividing cancer cells have an increased requirement for folic acid. It is known that FR-a levels are elevated in specific malignant diseases (solid tumors, leukemia) and thus the FR receptor serves as useful targeting moiety for the diagnosis …

Env Engineering Engagement, Maya Trotz

Service-Learning Syllabi

No abstract provided.

Hrc Enews — 2010 Fall, Megan K. Svarz

Publications (HRC)

This issue contains staff accomplishments and announcements, event listings, and a "new faces" listing for new staff, affiliates, and researchers.

Alterations In Multiple Measures Of White Matter Integrity In Normal Women At High Risk For Alzheimer's Disease, Brian T. Gold, David K. Powell, Anders H. Andersen, Charles D. Smith

Neuroscience Faculty Publications

There is evidence that disruption of white matter (WM) microstructure is an early event in the course of Alzheimer's disease (AD). However, the neurobiological bases of WM microstructural declines in presymptomatic AD are unknown. In the present study we address this issue using a multimodal imaging approach to the study of presymptomatic AD. Participants were 37 high-risk (both family history of dementia and one or more APOE4 alleles) women and 20 low-risk (neither family history nor APOE4) women. Groups were matched for age, education, neuropsychological performance, and vascular factors that could affect white matter. Whole-brain analyses of diffusion tensor imaging …

The Geometric Growth Of M&S Education: Pushing Forward, Pushing Outward, John A. Sokolowski, Catherine M. Banks

VMASC Publications

M&S education is experiencing a geometric growth that is placing it front and center as a discipline and as an interdisciplinary tool. This article discusses the evolution of the discipline of M&S. It answers: Why has M&S education experienced a forward and outward growth? What is it that makes this discipline unique? What is the current state of M&S education?

Cs 415: Social Implications Of Computing, Leo Finkelstein

Computer Science & Engineering Syllabi

CS 415 is a communication skills course using as its subject matter current salient issues associated with the social implications of computing. In addition to the course text, you will need to use certain reading materials in the library and elsewhere, and you will be responsible for using concepts and theories provided in class lectures and discussions.

Cs 302-01: Introduction To Oracle Sql Databases, Karen Meyer

Computer Science & Engineering Syllabi

Relational client server database design and access techniques. Includes building database tables, writing SQL and PL/SQL statements and programs and developing user interfaces using forms.

Detrimental Thoracoabdominal Interaction With Lateral Airbag Restraints, Jason John Hallman

Dissertations (1934 -)

Side impact motor vehicle crashes pose unique challenges for occupant protection, particularly with regard to torso injury mitigation. The minimal crush distance between the vehicle exterior and the occupant torso has necessitated advanced passive safety technologies in response to tightened regulatory requirements and increased public awareness of safety issues. In particular, lateral airbag restraints (side airbags) have undergone a rapid and unregulated introduction in recent years, with US availability increasing to over 90% of new vehicles in 2010. As with frontal airbag restraints, the prdissertationsity for injury to occupants in close proximity to side airbag deployment remains a concern. Test …

Wireless Sensing Without Sensors: An Experimental Study Of Motion/Intrusion Detection Using Rf Irregularity, Wei Qi Lee, Winston K. G. Seah, Hwee-Pink Tan, Zexi Yao

Research Collection School Of Computing and Information Systems

Motion and intrusion detection are often cited as wireless sensor network (WSN) applications with typical configurations comprising clusters of wireless nodes equipped with motion sensors to detect human motion. Currently, WSN performance is subjected to several constraints, namely radio irregularity and finite on-board computation/energy resources. Radio irregularity in radio frequency (RF) propagation rises to a higher level in the presence of human activity due to the absorption effect of the human body. In this paper, we investigate the feasibility of monitoring RF transmission for the purpose of intrusion detection through experimentation. With empirical data obtained from the Crossbow TelosB platform …

Development Of A Unique Whole-Brain Model For Upper Extremity Neuroprosthetic Control, Dominic Nathan

Dissertations (1934 -)

Neuroprostheses are at the forefront of upper extremity function restoration. However, contemporary controllers of these neuroprostheses do not adequately address the natural brain strategies related to planning, execution and mediation of upper extremity movements. These lead to restrictions in providing complete and lasting restoration of function. This dissertation develops a novel whole-brain model of neuronal activation with the goal of providing a robust platform for an improved upper extremity neuroprosthetic controller. Experiments (N=36 total) used goal-oriented upper extremity movements with real-world objects in an MRI scanner while measuring brain activation during functional magnetic resonance imaging (fMRI). The resulting data was …

2010 (Fall) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the fall of 2010.

Emotional Intelligence And Its Potential In Engineering Management, Jesse Ray Toepfer

Engineering Management & Systems Engineering Theses & Dissertations

Assuming that the modern connotation of Emotional Intelligence (El) took shape with Wayne Leon Payne's 1986 dissertation, A Study of Emotion: Developing Emotional Intelligence, Self-Integration, Relating to Fear, Pain, and Desire, EI is nearing its thirtieth birthday. Relatively speaking, EI is still very young, and there are a handful of researchers who are still trying to explore and define El. Significant efforts have been made to develop the concept of EI, and the ramifications of EI on an individual's professional performance.

Often more technical and exacting in nature, the field of engineering management exhibits many aspects that are unique relative …

The Circuit, Fall 2010, Department Of Electrical And Computer Engineering, Michigan Technological University

Department of Electrical and Computer Engineering Newsletters

Table of Contents

• Strategic Faculty Hiring Initiatives at Michigan Tech
• Tech Receives $3 Million to Develop EV Education Programs
• ECE Student Brings Laptops to Ghana
• Tech's Online Power Engineering Program Marks 10th Anniversary
• Dave House: Why Research is Key to the Future of Tech and to ECE
• Alumni Gifts Fund New Center for Computer Systems Research
• Faculty and Student News

Development Of Sustainability Indicators For Products And Processes, Sundeep Bodapati

Mechanical & Aerospace Engineering Theses & Dissertations

Significant increase in industrialization is a leading cause for the depletion of global resources and changes in the earth's atmosphere due to global warming. There has been a major concern for the manufacturing industry to deal with the above problems and this had led the researchers to focus on the area of sustainability. Sustainable development aims for the future, which is characterized by the interaction of the economic, environment and society. To enable the manufacturing companies to measure sustainability performance, developing the metrics for sustainability is critical. The purpose of this thesis is to review the indicators published in the …

Freight Transportation Analysis Comparison Of Short Sea Shipping To Conventional Transportation Modes, Vishwesh Vilas Parkhi

Mechanical & Aerospace Engineering Theses & Dissertations

Pollution due to transportation is one of the biggest concerns today. Freight transportation plays a significant role in this situation. Pollution can be reduced by minimizing the use of transport fuel. This can be achieved by selecting the most economical transport mode for long voyages for which fuel cost is one of the major costs. The model developed in this research helps in comparing the transport modes by evaluating cost per ton-mile. The three transportation modes of trucks, trains and Ro-Ro shipping vessels are considered in the model with very detailed costs associated with them. The major objective of this …

Engineering Design And Development, David Kennedy

Conference Papers

Combining Industrial and Functional Design methodologies for the development of new products and systems requires a broad understanding of human behaviour and industrial activities. The requirements of international standards, protection of the environment and the ability to make a profit on sales requires a sound attitude and approach to succeed, especially in current economic conditions. This highlights the importance of good business and management strategy that must be dynamic to meet the changing needs of the market. Competitiveness depends largely upon advances in the fields of design and Innovation, cutting edge research and new advances over a broad range of …

Intracellular Localisation, Geno- And Cytotoxic Response Of Poly N-Isopropylacrylamide (Pnipam) Nanoparticles To Human Keratinocyte (Hacat) And Colon Cells (Sw 480), Pratap Naha, Kunal Bhattacharya, Tiziana Tenuta, Kenneth Dawson, Iseult Lynch, Amaya Gracia, Fiona Lyng, Hugh Byrne

Articles

PNIPAM nanoparticles, with and without a covalentlylinked fluorescent label, were prepared by a free radical polymerisation technique. The cyto and genotoxicity of PNIPAM nanoparticles were analysed in two representative mammalian cell lines, SW480, a colon, and HaCaT, a dermal cell line. Physical characterisation in terms of particle size and zeta potential of the PNIPAM nanoparticles was carried out both in aqueous solution and in the appropriate cell culture media. Uptake and colocalisation of fluorescently labelled PNIPAM nanoparticles was monitored in both cell lines using confocal laser scanning microscopy. Genotoxicity analysis using the Comet assay was performed in both cell lines …

Ankle Strength And Functional Limitations In Children And Adolescents With Type I Osteogenesis Imperfecta, Angela Caudill, Ann Flanagan, Sahar Hassani, Adam Graf, Ruta Bajorunaite, Gerald F. Harris, Peter A. Smith

Biomedical Engineering Faculty Research and Publications

Purpose: To determine whether children with type I osteogenesis imperfecta (OI) exhibit ankle plantar flexor weakness and whether this correlates with physical function.

Methods: Twenty children and adolescents with type I OI and 20 age-matched controls (age 6-18 years) participated in a single evaluation session. Data included strength assessment, Gillette Functional Assessment Questionnaire, Pediatric Outcome Data Collection Instrument (PODCI), and Faces Pain Scale—Revised.

Results: Ankle plantar flexor weakness was evident in the OI group compared with the control group. Heel-rise strength correlated with ankle isometric plantar flexion strength. Limitations in PODCI subscales—sports and physical function and pain/comfort—are present in the …

Effect Of Friction Stir Processing On Microstructure And Tensile Properties Of An Investment Cast Al-7si-0.6mg Alloy, Saumyadeep Jana, Rajiv S. Mishra, John A. Baumann, Glenn J. Grant

Materials Science and Engineering Faculty Research & Creative Works

Friction stir processing (FSP) is emerging as a promising tool for microstructural modification. the current study assesses the effects of FSP on the microstructure and mechanical properties of an investment cast Al-7Si-Mg alloy. FSP eliminates porosity and significantly refines eutectic Si particles. the extent of particle refinement varied with changes in processing conditions. a high tool rotation rate and a low-to-intermediate tool traverse speed generated a higher volume fraction of finer particles. Tensile ductility changed significantly as a result of FSP, whereas ultimate tensile strength improved only marginally. Yield strength was similar in both cast and FSP samples under various …

Quantifying Benefits Of Traffic Signal Retiming, Christopher M. Day, Thomas M. Brennan Jr., Hiromel Premachandra, Alexander M. Hainen, Stephen M. Remias, James R. Sturdevant, Greg Richards, Jason S. Wasson, Darcy M. Bullock

JTRP Technical Reports

Improvements in the quality of service on a signalized intersection or arterial can be interpreted as a reduction in the user cost of service, which is expected to induce demand based on economic theory. This report presents a methodology for measuring and interpreting changes to user costs, and determining whether demand was induced. High-resolution signal event data and Bluetooth device MAC address matching are demonstrated in three case studies with the purpose of quantifying the impacts of changes in signal timing plans. In the first case study, 21 months of vehicle volume data are used to test whether demand was …

Fault-Injection Experiment For The Statistical Characterization Of Faults In Avionics Communication System, Amy M. Yates

Electrical & Computer Engineering Theses & Dissertations

Since flight control systems perform safety-critical functions, it is important to understand the possible effects on the closed-loop dynamical system's performance caused by these faults. The purpose of this project is to design the software and hardware needed to add fault-injection and monitoring capabilities to ROBUS-2, a flight communication system. ROBUS-2 is the current version of the fault-tolerant computer communication system used by the Scalable Processor-Independent Design for Enhanced Reliability (SPIDER), a general-purpose fault-tolerant integrated modular architecture (IMA) developed at the NASA Langley Research Center. The major components of SPIDER include processing elements (PEs) to perform calculations, bus interface units …

Dispersion Of Cytotoxic Properties Of Multi-Walled Carbon Nanotubes Suspended In Biological Solutions With Tween 80: Their Role In Enhancing Killing Effects Of Nanosecond Pulse Electric Fields On Tumor Cell Lines, Bhargava S. Kalluri

Biological Sciences Theses & Dissertations

The objective of this study was to determine whether multi-walled carbon nanotubes (MWCNTs) suspended in the surfactant Tween 80 give an additive killing effect on tumor cells when exposed to nsPEFs. In this study, MWCNTs were suspended in DMEM and RPMI with or without T80 (surfactant). The size distribution of MWCNTs suspended in these solutions was evaluated with a Delsa™ Nano Zeta potential and sub micro particle Size Analyzer and confirmed with microscopy. The cytotoxicity of MWCNTs dispersed in different concentrations of T80 was evaluated in PANC1 (Human pancreatic cancer cell line) and Jurkat cell lines (Human T-cell lymphoblast cell …

Identification Of An Archaeal Presenilin-Like Intramembrane Protease, Celia Torres-Arancivia, Carolyn M. Ross, Jose Chavez, Zahra Assur, Georgia Dolios, Filippo Mancia, Iban Ubarretxena-Belandia

Publications and Research

Background: The GXGD-type diaspartyl intramembrane protease, presenilin, constitutes the catalytic core of the c-secretase multi-protein complex responsible for activating critical signaling cascades during development and for the production of b-amyloid peptides (Ab) implicated in Alzheimer’s disease. The only other known GXGD-type diaspartyl intramembrane proteases are the eukaryotic signal peptide peptidases (SPPs). The presence of presenilin-like enzymes outside eukaryots has not been demonstrated. Here we report the existence of presenilin-like GXGD-type diaspartyl intramembrane proteases in archaea.

Methodology and Principal Findings: We have employed in vitro activity assays to show that MCMJR1, a polytopic membrane protein from the archaeon Methanoculleus marisnigri JR1, …

Fetal Breathing Movement And Its Distinctive Characteristics In Bio-Magnetic Data, Umit Deniz Ulusar

Theses and Dissertations

Magnetoencephalography (MEG) is widely used to study magnetic fields generated by the electrical activity of the human brain and can also be applied for fetal neurological health assessment. The fetal MEG (fMEG) signals are often contaminated with other bio-magnetic signals such as fetal breathing movement (FBM), which acts as an interfering factor for fetal neurological signals. This study was carried out to identify the bio-magnetic signals pertinent to the FBM. The fMEG signals were captured using superconducting quantum interference devices (SQUIDs) and the FBMs were recorded by an ultrasound-based video technique. The simultaneous recording is challenging since SQUIDs are extremely …

Signal Detection Framework Using Semantic Text Mining Techniques, Sithu D. Sudarsan

Theses and Dissertations

Signal detection is a challenging task for regulatory and intelligence agencies. Subject matter experts in those agencies analyze documents, generally containing narrative text in a time bound manner for signals by identification, evaluation and confirmation, leading to follow-up action e.g., recalling a defective product or public advisory for potential flu outbreak. Technical challenges to achieve effective signal detection include mining unstructured data, increasing document collections, and presence of multi-domain vocabulary. Lack of annotation and multi-domain vocabulary makes traditional semantic web mining ineffective. Use of heuristics to enhance bag-of-words type text mining to semantic text mining is a novel idea attempted …

Design And Wind Tunnel Testing Of Cal Poly's Amelia 10 Foot Span Hybrid Wing-Body Low Noise Cestol Aircraft, Kristina K. Jameson, David D. Marshall, Robert Ehrmann, Eric Paciano, Rory Golden, Dave Mason

Aerospace Engineering

California Polytechnic Corporation, Georgia Tech Research Institute (GTRI), and DHC Engineering collaborated on a NASA NRA to develop and validate predictive capabilities for the design and performance of Cruise Efficient, Short TakeOff and Landing (CESTOL) subsonic aircraft. In addition, a large scale wind tunnel effort to validate predictive capabilities for aerodynamic performance and noise during takeoff and landing has been undertaken.

The model, Advanced Model for Extreme Lift and Improved Aeroacoustics (AMELIA), was designed as a 100 passenger, N+2 generation, regional, CESTOL airliner with hybrid blended wingbody with circulation control. The model design was focused on fuelsavings and noise goals …

Mirthconnect Howto Document, Sebastien Pardon, Damon Berry

Reports

This document aims at describing the steps involved in installing and configuring Mirth Connect so as to produce an EN13606-compliant record extract from an HL7v2 message using the LinkedEHR- produced xquery.

Orbital Tori Construction Using Trajectory Following Spectral Methods, Ralph E. Bordner Iii

Theses and Dissertations

By assuming the motion of a satellite about the earth’s geopotential mimics the known Kolmogorov-Arnold-Moser (KAM) solution of a lightly perturbed integrable Hamiltonian system, this research focused on applying trajectory following spectral methods to estimate orbital tori from sampled orbital data. From an estimated basis frequency set, orbital data was decomposed into multi-periodic Fourier series, essentially compressing ephemerides for long-term use. Real-world Global Positioning System (GPS) orbital tracks were decomposed and reconstructed with error from as low as few kilometers per coordinate axis over a 10-week span to tens of kilometers per coordinate axis over the same time period, depending …

Providing A Theoretical Basis For Nanotoxicity Risk Analysis Departing From Traditional Physiologically-Based Pharmacokinetic (Pbpk) Modeling, Dirk P. Yamamoto

Theses and Dissertations

The same novel properties of engineered nanoparticles that make them attractive may also present unique exposure risks. But, the traditional physiologically-based pharmacokinetic (PBPK) modeling assumption of instantaneous equilibration likely does not apply to nanoparticles. This simulation-based research begins with development of a model that includes diffusion, active transport, and carrier mediated transport. An eigenvalue analysis methodology was developed to examine model behavior to focus future research. Simulations using the physicochemical properties of size, shape, surface coating, and surface charge were performed and an equation was determined which estimates area under the curve for arterial blood concentration, which is a surrogate …

Exploring The Effects Of International Traffic In Arms Regulations Restrictions On Innovation In The U.S. Space Industrial Base, Kalliroi L. Landry

Theses and Dissertations

The International Traffic in Arms Regulations (ITAR) are used to protect United States (U.S.) military technologies. However, changes to ITAR export controls regarding space technologies have had a major impact to the U.S. space industry. The literature mentions a concern for the health of lower-tier firms because they are a major source of innovation, but there is no additional information considering the effects of ITAR on space innovation at those lower tiers. The purpose of this thesis was to explore the implications of continuing the current ITAR restrictions with regard to innovation in the space industry. This research used a …