Digital Commons Network^™

Sex-Dependent Differences In Cardiac Function And Strain In Doxorubicin-Induced Cardiomyopathy, Anna J. A. Webb, Bea O. Cabot, Aasish Chowdary, Wilhelm S. Smith, Benjamin Zeidler, Cortland H. Johns, Craig J. Goergen

Discovery Undergraduate Interdisciplinary Research Internship

Doxorubicin is a chemotherapeutic agent used to treat many types of cancer. While effective, doxorubicin can cause cardiomyopathy, a disease affecting the heart muscle. Although the effects of doxorubicin on the heart are well studied, the mechanisms leading to cardiomyopathy are not well understood. Previous studies have used murine models to study the cardiotoxicity of doxorubicin. These reports showed that cardiac dysfunction is more pronounced in male compared to female mice. The goal of this study is to further evaluate sex differences in doxorubicin induced cardiomyopathy using 4-dimensional strain mapping techniques. In this study, both female and male C57Bl/6J mice …

Investigation Into Intraocular Pressure Distribution Via Computer Aided Engineering (Cae), Madison Maureen Hinman

Masters Theses

The leading cause for irreversible blindness and vision loss is glaucoma - an eye condition associated with elevated intraocular pressure (IOP). Increased IOP is also seen during other pathological conditions like spaceflight-associated neuro-ocular syndrome (SANS), and non-pathological conditions as when playing a wind instrument. The study aimed to describe the influence of different vitreous cavity size as well as vitreous fluid viscosity on the IOP as measured at the back of the eye on the retina. Improved understanding of eye pressure transmission can aid in a better understanding of eye diseases. The experiment conducted included cavities of varying size and …

A Novel, Metal-Based Approach To Identify Residences With Lead Service Lines, Danielle Land, Grant D. Brown, David M. Cwiertny, Marc A. Edwards, Mona Hanna, Drew E. Latta, Michelle M. Scherer

Michigan Tech Publications

There is an urgent need for rapid, cost-effective approaches to identify residences with lead service lines (LSLs). We evaluated whether analyzing water for corrosion-related metals could accurately identify residences with LSLs without relying on potentially inaccurate property records. We applied principal component analysis logistic regression (PCA-LR) and classification tree models using 28 analytes per bottle (including Pb, Cu, Zn, Fe, Al, and others) measured in 216 water samples collected in Flint, Michigan, in August 2015. The PCA-LR model achieved 87% accuracy (AUROC = 0.93) with 81% sensitivity and 90% specificity, while the classification tree model achieved 80% accuracy (AUROC = …

Development Of Adjustable Static Test Equipment For Below-Knee Prosthetic Feet: A Case Study, Firmansyah Hafizh Rizal Nurrokhim, Fauzan Raka Mawandi, Puspa Dinda Safitri, Imam Mahmudah, Dwiky Mirnanda, Ndaru Adyono, Wahyu Dwi Lestari

Journal of Mechanical Engineering Science and Technology (JMEST)

The high prevalence of physical disabilities in Indonesia, particularly among the productive-age population, highlights the urgent need for advancements in prosthetic technology. While local fabricators have begun producing prosthetic feet, the lack of standardized testing procedures compromises safety and performance. This study addresses that gap by developing an adjustable static testing device tailored for below-knee prosthetic feet, focusing on keel and heel tests to evaluate mechanical performance. The device includes a jig-fixture platform adjustable to 8° and 15° for heel and keel tests, respectively. It applies a 1230 N load based on AOPA standards and integrates load and displacement sensors …

Investigation Of The Influence Of Warhead Shape And Type Of Missile Weapon Material Counter-Training Tank Weapons Simulation Approach, Transisma Budiarta, Haris Puspito Buwono, Radhi Nurvian Amrullah

Journal of Mechanical Engineering Science and Technology (JMEST)

This study analyzes the effect of warhead shape and material variations on pressure, temperature, and lift on training missiles using CAD-based simulation methods. The variations of warhead shapes tested include flat, flat radius, and tapered, while the materials used are rubber, ABS, and PE. The simulation results show that the tapered warhead shape with PE material produces the lowest pressure (50.3 MPa) due to more efficient pressure release and low friction properties. Conversely, the Flat shape produces the highest pressure (69.1 MPa) on all materials due to flow stagnation. In terms of temperature, the Flat Radius warhead with PE and …

Tear Resistance Evaluation Of Room Temperature Vulcanizing Silicone Rubber: A Comparative Study, F R. Mawandi, P D. Safitri, D Mirnanda, F H. R. Nurrokhim, Ndaru Adyono, W D. Lestari

Journal of Mechanical Engineering Science and Technology (JMEST)

Room Temperature Vulcanizing (RTV) silicone cures at room conditions, providing tear resistance and flexibility to a wide range of industries. Yet, its mechanical performance improvement continues to be difficult when it is filled and catalyzed. In this work, the tear resistance of three RTV materials—RTV 48, RTV 683, and RTV M4503—is investigated with different talc (2–4 wt.%) and catalyst (40–60 wt.%) formulations. Tear resistance testing per ASTM D624 yielded average and standard deviation values for material consistency determinations. Comparative analysis is also given in the research to ascertain the effect of over-cross-linking on elasticity and structural morphology. RTV 48 experienced …

Utilization Of Biomass From Kerai Payung Trees And Waste Paper Through Pyrolysis Technology To Support The Zero-Waste Concept, Anggita Putri Indadari, Nurfa Anisa, Asih Budi Santoso

Journal of Mechanical Engineering Science and Technology (JMEST)

Wisnuwardhana University is a private institution with a green campus environment surrounded by Kerai Payung trees. This environment produces organic waste from trees and inorganic waste such as used paper from campus activities. This study aims to achieve zero-waste processing by using pyrolysis technology to process campus waste, ensuring minimal residue. The experimental method involves comparing waste processing outcomes between conventional combustion and pyrolysis, the data was analyzed by comparing the results of pyrolysis with conventional combustion. The results of biochar from the pyrolysis process of used paper, Kerai Payung leaves, and nagging Kerai Payung tree are 76 g, 250 …

Influence Of Different Nanoparticles On Thermophysical Properties And Wear Resistance Of Corn Oil-Based Cutting Fluid In Mql-Cnc Milling Machining, M Nuril Anwar Habiby, Poppy Puspitasari, Aminnudin Aminnudin, Diki Dwi Pramono, Ahmad Atif Fikri, Mariyam Jameelah Ghazali

Journal of Mechanical Engineering Science and Technology (JMEST)

Vegetable oil-based cutting fluids have emerged as a promising innovation in machining operations, supporting the advancement of sustainable and eco-friendly manufacturing practices. This study delves into the development of a biolubricant derived from corn oil, enriched with 0.15% mass fractions of various nanoparticles, including calcium carbonate (CaCO3), copper oxide (CuO), and multi-walled carbon nanotubes (MWCNT). These nano-cutting fluids were applied through the Minimum Quantity Lubrication (MQL) method during CNC milling of AISI 1045 steel. The investigation focused on evaluating thermophysical properties, including density, thermal conductivity, and dynamic viscosity, as well as tool wear performance. The results demonstrated that CuO nanoparticles …

Wireless Sensor Networks In Renewable Energy Monitoring: A Comprehensive Survey Of Protocols And Applications, Atheer Yousif Oudah, Lina M. Shaker

AUIQ Technical Engineering Science

The global shift to sustainable energy has heightened the demand for smart, robust, and efficient monitoring systems. Wireless Sensor Networks (WSNs) play a key role by enabling real-time data collection, decentralized control, and flexible communication in renewable energy applications. This review presents a comprehensive analysis of WSN architectures, routing protocols, and deployment strategies tailored to photovoltaic (PV) arrays, wind energy systems, hydroelectric plants, and smart microgrids. Core operational challenges are examined through a critical evaluation of energy-aware routing protocols including LEACH, PEGASIS, TEEN, ZRP, and advanced variants like EE-OLEACH and PT-Hybrid. Real-world applications, such as offshore wind farms, rooftop PV …

Comparative Analysis Of Linear And Non-Linear Feature Selection For Breast Cancer Detection With Shap Analysis, Hamza Sabo Maccido

AUIQ Technical Engineering Science

Breast cancer remains one of the leading causes of mortality worldwide, emphasizing the critical need for accurate and efficient diagnostic tools. This study investigates the effectiveness of combining linear and non-linear feature selection methods-Principal Component Analysis (PCA), Pearson Correlation Coefficient (PCC), and Backpropagation Neural Networks (BNN) to improve breast cancer classification using machine learning models. We utilized the Wisconsin Breast Cancer Dataset to evaluate the performance of five classifiers-Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Logistic Regression (LR), Decision Tree (DT), Naïve Bayes (NB) and Artificial Neural Network (ANN). The results demonstrated that BNN-selected features consistently outperformed PCA and PCC …

Corneal Elevation Maps Patterns Classification Using Correlation Method, Sura M. Ahmed, Nebras H. Ghaeb, Salman Yussof, Noor T. Al-Sharify, Husam Yahya Nser, Zainab T. Al-Sharify, Ong Hang See, Leong Yeng Weng

Iraqi Journal for Computer Science and Mathematics

The ophthalmologist uses various techniques to diagnose corneal abnormalities, including corneal topography and tomography devices. Currently generated color corneal elevation surface maps from topographic imaging devices are essential for detecting ocular diseases, while accurately classifying these maps to differentiate between different shapes remains an issue. This study aims to assess and compare parameters of the front and back corneal surface elevation map patterns of normal/abnormal corneas. Two hundred cases were randomly taken (100 normal and 100 abnormal) with a single normal reference image, and then an additional 25 cases were added later for the optimization process. The preprocessing of all …

Retracted: Comparative Study Based On Continuous Analysis Of Autism Spectrum Disorder Using Advanced Deep Learning With Model Interpretability Insights, Ayan Sar, Hussain Falih Mahdi, Sumit Aich, Pranav Singh, Tanupriya Choudhury

Iraqi Journal for Computer Science and Mathematics

Hysterical conversion has similar cognition and behaviours to those in the case of ASD; it is, therefore, complex when diagnosing and classifying the condition. The majority of employed diagnostic tests are cross-sectional and fail to describe the developmental and clinical features of ASD; for this reason, they are pretty inaccurate in the diagnosis of ASD and thus cause disparities in the efficiency of the therapeutic interventions used. The present study's research contribution is a new application of deep learning that aims to analyse the spectrum of ASD with gradient-based classifications. In this case, we use a DL model trained on …

Understanding The Metallic And Oxide Phases In Platinum-Based Bimetallic Heterogeneous Catalysts After High-Temperature Oxidation, Stephen John Porter Jr

Nanoscience and Microsystems ETDs

Platinum (Pt) and palladium (Pd) are critical components in diesel emission control systems, enabling the conversion of harmful pollutants under demanding conditions. However, Pt’s effectiveness is hindered by sintering under high-temperature oxidizing environments. This dissertation investigates how Pt and Pd evolve under oxidizing conditions at 800°C, highlighting their distinct thermodynamic behaviors and interactions. Using TEM, EDS, EELS, XRF, XRD, and EXAFS, we show that Pd suppresses Pt sintering by reducing the volatility of PtO₂, leading to the formation of stable particles. Both Pt and Pd are present in metallic and oxide states, forming biphasic 'Janus' particles with conjoined metal and …

Advancements In Microarray Manufacturing Enable Emerging Technologies, Kendall Hoff

Biomedical Engineering ETDs

Significant advances in manufacturing technologies have enabled the production of new DNA microarrays for use in emergent technology. Photolithography, wafer scale manufacturing, and improvements in synthesis chemistry and design enable high-throughput production of extremely high-quality arrays. These new arrays offer extremely high oligonucleotide densities, in the range of tens of thousands of oligonucleotides per square micron. They also offer smaller features sizes, with millions of features per square centimeter. Furthermore, they can be manufactured with the DNA tethered at either end to the surface, leaving either the 5’ or 3’ end free and available for use in enzymatic reactions; and …

Finite Element Investigation Of Blast Load Responses In Nuclear Power Plant Containment Structures, Janak Raj Awasthi

Civil Engineering ETDs

Some significant incidents like the Chernobyl disaster (1986), the Fukushima Daiichi hydrogen explosion (2011), and some frequent military and terror threats to the nuclear Power plant structures have led to studying the capacity of power plant structures to withstand blast loadings. From this research, even one-third of the loss of the coolant is enough to damage the power plant structure. Crack starts from the wall and propagates toward the top of the dome and the foundation. The external blast shows high damage symptoms near the foundation area. Most of the steel members, including the rebars, Liner, and Tendons, showed high …

Exploring Immune System Through Computational Modeling: A Comprehensive Study Of Lymph Nodes And Immune Response Scaling, Vaccine Efficacy, And Large-Scale Extreme First Passage Time, Jannatul Ferdous

Computer Science ETDs

The adaptive immune response is a complex defense mechanism that develops over time to recognize and eliminate pathogens with remarkable precision and durability. This dissertation investigates the dynamics, scaling, and efficiency of the adaptive immune response through a synthesis of computational modeling, mathematical analysis, and agent-based simulations. First, we analyze the topology of the lymphatic network and investigate the T cell search time to find the lymph node that is containing the matching dendritic cell. Second we show how the scaling of lymph node number and volume with body mass, leads to scale-invariant search times for T cells locating antigen-bearing …

Network Intelligence For Next-Generation Wireless Networks: Advancing Distribution And Coordination, Yonatan Melese Worku

Electrical and Computer Engineering ETDs

Next-generation wireless networks, encompassing 6G and beyond, face rigorous demands for ultra-low latency, ubiquitous connectivity, exceptionally high data rates, and robust security, necessitating innovative approaches to resource optimization and network protection. This dissertation proposes a pioneering framework that synergizes advanced methodologies—deep reinforcement learning, deep learning, blockchain, and multi-agent systems—to address these challenges. Distributed architectures, underpinned by AI-driven multi-agent systems, form the backbone of this framework, enabling seamless integration and intelligent orchestration across diverse domains. The research advances IoT-based systems leveraging machine learning for resource efficiency in healthcare applications, develops reinforcement learning-driven frameworks to optimize energy and coverage for Unmanned Aerial …

Targeted Delivery Of Rapamycin Via Epidermal Growth Factor Receptors In Pancreatic Cancer Cells Inhibits Cell Proliferation And Induces Apoptosis, Adeolu S. Oluremi, Christofer Baldwin, Nickolas L. Gustavision, Mujeebat Bashiru, Adeniyi Nsiah Oyebade, Noureen Siraj, Raj Raghavendra Rao, N. Ali

Biomedical Engineering Faculty Publications and Presentations

Pancreatic cancer (PC) is aggressive and deadly; most PC cells overexpress an epidermal growth factor receptor (EGFR). EGFR-targeting peptide (GE11) was conjugated to gold nanoparticles (AuNPs) for delivering rapamycin (Rap), an mTOR inhibitor that reduces proliferation and induces apoptosis. Biophysical techniques confirmed the conjugation. Rap loading efficiency was 41.5%, with sustained release at a lower pH. Conjugates showed higher uptake in PANC-1 cells than unmodified AuNPs. It also inhibited proliferation and induced apoptosis via pathways involving reactive oxygen species, mitochondrial damage, and caspase activation. This approach represents a promising nanoparticle-based therapeutic strategy targeting PC cells, utilizing GE11-EGFR interactions to minimize …

Ai-Based Object Detection And Risk Identification For Enhanced Construction Site Safety, Mahdi Bonyaniakbarabadi

LSU Master's Theses

Recent advancements in computer vision for construction site safety have encountered significant hurdles, especially in the nuanced tasks of object detection and the identification of unsafe worker behaviors. These challenges are often exacerbated by complex and cluttered backgrounds, wide variations in object scale, and inconsistent image quality. While existing methodologies have utilized attention mechanisms to analyze spatial and temporal features, they frequently neglect the benefits of adaptive sampling and channel-wise feature adjustments, thereby failing to exploit potential spatiotemporal redundancies. This thesis introduces a two-pronged approach to address these limitations. First, we propose the Optimized-Position Network (OP-Net), a novel architecture for …

07.28.2025 Ored Connect, Liz Williamson

ORED Newsletter

On-demand training courses released

• Mentoring
• My Project Was Funded, Now What?

Notice of Funding Opportunity SMART Act Accelerate Initiative

Memo Regarding Contact from Federal Agencies

Magnetic Macro Pendulum Design And Real-Time Control Application: Simulation And Experiment, Hüseyi̇n Yildiz, Serdar Yilmaz, Yasemi̇n Poyraz Koçak, Erol Uzal

Turkish Journal of Electrical Engineering and Computer Sciences

Over the last decade, the number of studies in the field of magnetic micro robots has significantly increased due to expectations of performing microsurgery, drug delivery, and similar medical procedures. Magnetic micro robots have advantages over other types of micro robots in terms of having independent designs for rotor and stator structures. Magnetic micro robots can be controlled by magnetic fields and can be programmed to move in certain directions and to perform various functions. This paper implements the computer-aided real-time control of a single-arm micro-pendulum structure to (eventually) perform cell manipulation tasks. The mechanical structure, mathematical model, control circuit …

Analysis Of A Saline Dust Storm From The Aralkum Desert – Part 2: Atmospheric Flow Precursors In The Euro-Atlantic Region, Xin Xi

Michigan Tech Publications

Wind-blown dust emissions from the man-made Aralkum Desert pose significant environment and human health risks across Central Asia. Yet, little is known about the atmospheric circulation patterns favoring dust outbreaks from the region. This study examines the role of upstream atmospheric blocking and recurrent transient Rossby wave packets (RWPs) in initiating a severe dust storm from the Aralkum Desert in May 2018. Results show that the dust event was triggered by an unusual early-summer cold air outbreak and attendant postfrontal northerly winds reaching 24–31 m/s. The compound cold air and dust outbreaks were preceded by repeated meridional flow amplification linked …

The Operational Performance Of Buildings In A Humid Subtropical Climate: Insights From Empirical Data And Assessment Models, Oluwafemi Awolesi

LSU Master's Theses

This thesis evaluates the operational performance of residential and non-residential buildings in a humid subtropical climate, emphasizing Indoor Environmental Quality (IEQ) and energy performance through empirical data and assessment models. Motivated by the increasing need for integrated sustainability evaluations, this study combines a systematic review with multi-method field investigations to advance understanding in this domain. The systematic review critically analyzed 99 case study articles, identifying dominant IEQ assessment methodologies and highlighting methodological inconsistencies that hinder cross-study comparability. Emerging computational approaches, although promising, remain underutilized. The review advocates for standardized, climate-responsive, and feedback-oriented evaluation frameworks. Field investigations assessed IEQ and energy …

Targeting Poor Solubility Of Docetaxel: Computational Screening Of Ionic Liquids Using Cosmo-Rs, Najihah Mohd Noor, Amal A.M. Elgharbawy, Huma Warsi Khan, Yumi Zuhanis Has-Yun Hashim, Muhammad Moniruzzaman, Mohd Firdaus Abd. Wahab, Hamzah Mohd Salleh, Siti Nur Idayu Matusin

Publications and Research

Docetaxel (DTX), a chemotherapeutic agent widely used in cancer treatment, has limited therapeutic efficacy owing to its poor oral absorption and low bioavailability. This study aims to improve DTX solubility by predicting its compatibility with ionic liquids (ILs) using conductor-like screening model for real solvents (COSMO-RS) computational modelling. A library of 340 ILs comprising 17 cations and 20 anions was screened for their potential to dissolve DTX, with a particular focus on imidazolium-based ILs that enhance its solubility and pertinence to cytotoxic applications. Computational analysis identifies ILs containing cations such as 1-methylimidazolium [MIM] and 1,3-dimethylimidazolium [DMIM] and anions such as …

Detection Of Oil Pollution On The Tigris River In Iraq Using Fluorescence And Reflecting Techniques, Ahmad K. Ahmad, Thamer M. Mohammed

Karbala International Journal of Modern Science

In this study, a broadband light source (visible and ultraviolet) was used to name minerals via fluorescence spectra and estimate slick oil thickness, ranging from sub-millimetres, using the reflecting spectrum technique. Using a fluorescent technique, we obtained fluorescence spectra of the samples, converting and processing the signals to produce high-resolution data, which enabled the identification of the types of dissolved elements and oil slicks in the Tigris River, highlighting pollution sources and potential control measures. This system aims to show the faint signal in fluorescence samples collected from the cooling system outlet water throughout the refining process from AL-Dora (Baghdad) …

Trace Element Migration In Groundwater In Sandstone Aquifers In The Jurassic Coalfields: A Case Study Of The Guojiahe Coal Mine, Shi Longqing, Qu Xingyue, Cheng Hao

Coal Geology & Exploration

Background The Ordos Basin, a vital energy hub in China, contains considerable coal reserves. However, the environmental issues arising from coal mining warrant attention, especially given the fragile ecosystems of the Jurassic coalfields. Methods This study investigated the Guojiahe Coal Mine in Shaanxi Province. Based on measured concentrations of 31 trace elements dissolved in sandstone aquifers across varying geological ages, this study conducted a comparative analysis of the evolutionary characteristics of these trace elements between unmined reducing and post-mining oxidizing conditions using numerical simulations. Accordingly, it revealed the impacts of coal seam mining on trace element migration in groundwater in …

Research On Monitoring And Early Warning Systems For Mine Water: Progress And Prospects, Yin Shangxian, Ding Yingying, Lian Huiqing, Dong Donglin, Du Tong, Yin Huichao, Zhao Peng, Zhang Yi’An, Wang Xiong

Coal Geology & Exploration

Background Water disasters in mines are occasional accidents occurring due to the influence or triggered by mining-induced intense changes in geological bodies. The complexity, heterogeneity, and dynamics of geological bodies, coupled with the random and instantaneous nature of mining influence, lead to the uncertainty, instability, occasionality, and transience of water disasters in mines. Given that mine water monitoring and early warning serve as a prerequisite for advanced disaster prevention and control, their research and system construction hold great theoretical significance and practical value. Progress and Prospects Fighting against water disasters in mines is conducted throughout the development and utilization of …

Enhanced Energy Harvesting From Nf-Pvdf Piezoelectric Material For Wearable Electronics: I– V Characterization And Charge-Discharge Performance, Ahmed Emara, Afaf Farag, Gehad Ali, Mohamed Mamdouh, Sameh O. Abdellatif, Khaled Nassar, Tamer Hamoud

Electrical Engineering

This study explores the utilization of fabricated piezoelectric polyvinylidene fluoride nanofiber (NF-PVDF) materials in wearable electronic sensing applications by investigating their current-voltage ( I − V ) characteristics under controlled ultra-low-frequency excitation forces. The results demonstrate a significant power harvesting capability, achieving an output power of 0.12 µW/mm2 at an operating point of 5.04 V and 7.7 µA. Additionally, the piezoelectric harvester was integrated into a charging-discharge circuit alongside a rectifier capacitor and a typical IoT wearable sensor, leveraging the advantages of a flexible substrate. Experimental measurements of the charging and discharging curves confirm the effective energy management of the …

Multi-Objective Allocation Optimization Model For Water Resources From A Coal Mine In The Inner Mongolia-Shaanxi Contiguous Area, Miao Hechao, Dong Shuning, Wang Hao, Yang Yuanyuan, Qiao Wei, Wang Xiaodong, Wang Dongqi, Fu Hongyang, Liu Yuting

Coal Geology & Exploration

Objective In China, as coal resource exploitation shifts gradually from eastern to western regions, coal bases in the western region play an increasingly notable foundational role in the basic energy supply in the national economy. However, due to its fragile ecosystems, the safe, efficient, and green coal exploitation of this region has long been challenged by the contradiction between the prevention and control of water hazards and the conservation of water resources. Therefore, advancing intelligent mine water control technology is identified as a crucial method to address the conflicts between coal mining and mine water in the western region. Additionally, …

Groundwater Rebound And Seepage Characteristics And Water Quality Evolution In A Sealed Mining Area In North China Type Coalfield, Yin Huiyong, Sun Dehui, Dong Fangying, Wang Fanhua, Zhang Lifeng, Wu Tao, Liu Chao, Zeng Yifan

Coal Geology & Exploration

Background The seepage field and water quality evolution associated with the groundwater rebound induced by the sealing of mining areas significantly affects the prevention and control of mine water hazards, as well as the recycling of water resources. Systematically elucidating the mechanisms underlying the seepage-hydrochemistry synergy of groundwater is recognized as a fundamental scientific issue for promoting the collaborative management and resource development of the water systems in mining areas. Methods Based on the engineering background of the sealed No.116 mining area in the Binhu Coal Mine, Zaozhuang, Shandong Province, this study investigated the groundwater rebound and seepage characteristics, along …