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A Novel Microfluidic Device For Preclinical Testing Of Chemotherapeutics, Kaija Saleh Ogan

Master's Theses

This work demonstrates the feasibility of a novel microfluidic tumor model that reproduces physiologically relevant nutrient gradients and endothelium–tumor interactions, validating its potential as a preclinical test platform. Finite element simulations of glutamine diffusion and fluid dynamics aligned with experimental tracer studies, and co-cultures supported directed endothelial migration toward tumor spheroids, confirming the device’s ability to mimic in vivo–like behavior.

Current preclinical models often fail to capture the complexity of the tumor microenvironment (TME), limiting their predictive value for therapeutic testing. Nutrient availability and angiogenic signaling are critical drivers of tumor progression, yet they are poorly represented in traditional …

(R2120) Flexible Group Service Map/Ph/1 Queueing Model With Working Vacation And Optional Service, G. Ayyappan, S. Kalaiarasi

Applications and Applied Mathematics: An International Journal (AAM)

There are many uses of queues, where services are provided in groups; these types of queues are widely studied in the literature. In this paper we examine a particular queueing model wherein the services are provided in groups and the group size may be less than or equal to the size initially fixed. The arrival follows a Markovian arrival process. The service time of each individual customer follows phase type distribution. The maximum of each customer’s individual service time within a group is defined as the group’s service time. At the service completion moment if there are fewer customers than …

Muscle Impulse Transducer: Research, Pre-Pilot Experiments, And The Design Of A Pilot Study For Quadriplegic Spinal Cord Injured Subjects For The Development Of A Novel Device, Marta Oreglia

Master's Theses

Paralysis due to spinal cord injury is a challenging condition that affects millions of people around the world. The Muscle Impulse Transducer (MIT) is a novel, wearable device that can be used to improve grip strength in the hand by using functional muscle impulses as a trigger for stimulus delivery to weakened or paralyzed nerves, to induce contraction of a paralyzed or paretic muscle. The MIT is still in development, with proof of concept [1], and functional prototypes [2] achieved. In this thesis, research was conducted on the best methods for functional electrical stimulation, EMG data collection, and nerve stimulus …

Molecular Dynamics Simulations Of Biologically Relevant Interfaces: From Tear Film Lipid Layers To Rna Adsorption On Silica Surfaces., Mahbuba Khanom

Electronic Theses and Dissertations

Molecular dynamics (MD) simulation is an important tool in biochemical sciences for studying complex molecular processes and interfacial interactions at the molecular level. Biological interfaces play key roles in processes such as ocular lubrication and biomolecular adsorption. This dissertation studies interfacial phenomena involving two distinct yet conceptually related systems: the tear film lipid layer (TFLL) at the air–water interface at the surface of the human eye, and RNA adsorption on silica surfaces. These studies provide insight into how interfacial composition, structure, and environmental conditions affect larger-scale behavior. Atomistic MD simulations were used to model the TFLL. The TFLL is essential …

Integrating Due Process Into Large Language Models., Joshua Paul Johnson

Electronic Theses and Dissertations

This research investigates the ability of large language models (LLMs) to recognize due process issues. Due process is a legal concept focused on the protection of the individual during interactions with government when life, liberty, or property are being impacted. Due process presents both substantive and procedural aspects that are challenging to incorporate into generative artificial intelligence. Through assessing model performance, creating benchmarking techniques, retrieval-augmented generation (RAG), and fine-tuning, this work seeks to measure due process recognition performance and improve performance in identifying due process issues. The results of evaluating larger parameter LLMs such as from Google, Meta, and OpenAI …

Isolated Dc-Dc Converter For An Ev Microgrid, Oscar Yu, William Leiker

Electrical Engineering

This product is a redesign of a DC-DC buck-boost converter which utilizes a new topology, the flyback converter, for use in an electric vehicle (EV) as a microgrid. The main driver behind the redesign is to provide electrical isolation between elements in the microgrid. The EV microgrid consists of the battery, motor, external DC and AC ports, and the power electronics (DC-DC converter and AC-DC inverter) which were designed and built in previous senior projects. Using EV’s as microgrids can help relieve stress from the main power grid caused by charging electric vehicles. Implementing EV’s as a microgrid enables the …

Using Noninvasive Calibrated Cuff Plethysmography To Observe The Effects Of Lifestyle Habits On Arterial Compliance, Joshua M. Whitaker

Master's Theses

Cardiovascular disease remains as a leading cause of death for both sexes and across all racial backgrounds. Continuing to research causes, early predictors, and preventative actions are paramount to ensuring that cardiovascular disease starts to decrease in its activity. Endothelial dysfunction is the earliest known predictor of cardiovascular disease, therefore investigating early detection methods of endothelial dysfunction can improve health outcomes. This study revolves around a non-invasive calibrated cuff device that uses the principles of segmental plethysmography and oscilliometry to measure arterial compliance of baseline and induced hyperemic conditions in human subjects to determine how well arteries vasodilate in response …

Evaluating The Preparedness Of Local Zoning Regulations For Flood Risk Reduction In The Most Affected Local Jurisdictions In Nebraska, Md Asaduzzaman Noor

Community and Regional Planning Program: Theses

Flooding has profound social, economic, and environmental impacts on local communities, and zoning plays a critical role in mitigating these risks. The 2019 Nebraska floods, among the most severe in the state’s history, highlighted the urgent need to strengthen local preparedness and mitigation strategies. This study assesses the extent to which local zoning regulations in Nebraska’s most affected jurisdiction, including rural areas, address flood risk reduction. A systematic review of 117 zoning ordinances from counties, cities, towns, and villages, we applied a structured analytical framework encompassing regulatory and permitting policies, voluntary and incentive-based measures, and nature-based solutions. The results show …

Dendrimer Gel Nanoparticles With Dual-Targeting Of Upar And Ribonucleotide Reductase R2 Influence Necrosis, Apoptosis, And Cell Cycle Arrest In Triple-Negative Breast Cancer, Hsin Yin Chuang, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited treatment options due to the absence of estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors. We previously developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles (GDP-uPA/GTI) with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2) to achieve selective antitumor effects. In this study, we investigated the underlying mechanisms of GDP-uPA/GTI-induced tumor inhibition. In vivo, GDP-uPA/GTI significantly downregulated R2 expression and activated caspase 8 and caspase 3, indicating caspase-dependent apoptosis. Histological evaluation of major organs revealed no observable toxicity. …

Upcycling Commodity Polymers To Advanced Materials For Energy And Environmental Sustainability, Anthony Griffin-Espinoza

Dissertations

Synthetic polymers play an essential role in nearly every aspect of our lives. Extending beyond single-use packaging, polymeric material design has progressed to attain tailorable architectures granting exceptional performance across advanced applications, including carbon-fiber reinforced polymer composites for aerospace, conductive materials for soft electronics, and drug carriers for biomedicine. While highly promising, intricately designed polymers needed to achieve excellent performance often have limited processability, complex synthetic methods, and expensive precursors. Furthermore, due to a lack of recyclability, commodity polymer waste streams result in both environmental impacts and a substantial loss of economic value. This dissertation focuses on developing robust strategies …

Privacy Preserving-Based Artificial Intelligence For Precision Agriculture, Partha P. Sengupta

Dissertations

The research work finds a solution to precision agriculture of cotton cultivation using artificial intelligence (AI) models. Two sets of model performance based on the application are selected namely a low resource and a high resource setting. This is because using drone surveys to capture images identifying the classes of stressed and unstressed cotton plantation requires limited model architecture and CPU based computation. Thus, traditional AI models were selected for low resource settings. Again, for high computation intensive models like transfer learning-convolution neural network (CNN) based architectures were grouped into high resource settings. There was another issue of class imbalance …

Understanding Crystallization Behaviors Of Polyethylene-Derived Vitrimers, Sara Valdez

Dissertations

Polyolefins (POs), particularly polyethylene (PE) and polypropylene (PP), are among the most widely utilized polymers globally, valued for their low production costs and favorable mechanical properties stemming from their semicrystalline microstructure. However, their extensive use and improper disposal have raised serious environmental and human health concerns. In response, PO-derived covalent adaptable networks (CANs) have emerged, integrating dynamic chemistries to enable recyclability and sustainable end-of-life strategies. While existing literature has largely focused on novel CAN systems, structure–property relationships, and network rearrangement in relation to thermal transitions (e.g., topological freezing temperature), the influence of network formation on crystallinity and crystallization kinetics remains …

Optimizing Indigenous Timber Short-Gap Crossing Designs By Minimizing Wood Moisture Content, Robert Greenwood

Graduate Theses and Dissertations

Reducing moisture content increases wood strength and reduces the weight of timber members. An accurate and efficient method for measuring moisture content is important for the design and construction of indigenous timber short-gap crossings. This study evaluates different methods for measuring moisture content in timber, describes a methodology for developing a representative moisture content value for a timber log, and approaches for quickly drying large timber logs. The results of this thesis will support activities in developing a representative moisture content of a log for structural design purposes and reducing weight for constructability purposes. The approaches discussed were developed considering …

Using Scenario-Based Design Activities To Explore Sociotechnical Thinking In Engineering Professionals, James M. Whealan

Master's Theses

Sociotechnical thinking is the ability to recognize the interconnectedness of both technical and non-technical dimensions such as environmental, economic, social, cultural, and political factors. Although traditional engineering curriculum often emphasizes technical knowledge and skills, research suggests that engineering work is inherently sociotechnical. While sociotechnical thinking is a critical engineering skill, relatively little is understood about the nature of it or the different aspects comprised within it. To that end, this study addresses the following research question: What sociotechnical factors do engineering professionals consider in a collaborative scenario-based design activity? To answer this question, we conducted a qualitative study of engineering …

The Importance Of Leader-Member Exchange And Psychological Contracts In Highly Qualified Researchers, Robin L. Ingerick Dba

Theses & Dissertations

This study examined the significance of the relationship between leader-member exchange (LMX) and psychological contracts in United States-based research organizations. When the organization-manager-employee relationship deteriorates, psychological contract breaches can occur, negatively affecting employee outcomes and the organization's financial success and stability. Existing knowledge highlights several factors that influence relationships, including reciprocated treatment, work behaviors and reactions, trust, professional respect, affect, mutual interaction, work autonomy, communication, job satisfaction, and fulfillment. The study sought to determine to what extent is there a predictive relationship between LMX and psychological contracts (employee obligations, employer obligations, fulfillment, and contract transitions) of highly qualified United States-based …

Evaluating Crumb Rubber Modified (Crm) Asphalt As A Sustainable Binder Alternative For High-Friction Surface Treatments, Abdallah Aboelela, Alireza Roshan, Magdy Abdelrahman

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

High-friction surface treatments (HFSTs) are widely applied to improve pavement safety by enhancing long-term skid resistance. Although epoxy resins are commonly used due to their strength and durability, their high cost, susceptibility to delamination, incompatibility with substrates of flexible pavements, and adverse environmental concerns limit their long-term performance. This study presents crumb rubber modified (CRM) asphalt as a sustainable alternative binder for HFST applications. CRM binders offer high performance and compatibility with existing pavement surfaces, cost effectiveness and reduced environmental impacts as compared to epoxy binders. In addition, the binder development utilizes enhanced recycling technologies for interacting with used tire …

Comparison Of The Recent Icrp Occupational Intakes Of Rradionuclides Series To Annual Limits On Intake (Ali) In The United States For Select Radionuclides, Aidan B. Barker

All Theses

Dose coefficients (DCs) and secondary limit values (such as the annual limit on intake [ALI] and derived air concentration [DAC]) are useful and convenient quantities in radiation protection (RP) for estimation of radiological dose and the practical application of dose limits. DCs link radioactivity intake to dose while secondary limit values express a dose limit in terms of the type and extent of exposure. The International Commission on Radiological Protection (ICRP), an international organization which provides guidance and recommendations for RP, calculates, tabulates, and updates DCs following new findings and updated knowledge relevant to dose determination (e.g. improved human biokinetics, …

Advancement Of Wearable Hardware & Possible Cross-Sector Applications, Yassine Chahid, Patrick Slattery

Publications and Research

This study examines recent advances in wearable technologies including smart glasses, watches, rings, and related devices. It evaluates their applications across healthcare, manufacturing, education, and logistics. As real-time data collection, hands-free interaction, and continuous health monitoring become more prevalent, wearables are emerging as pivotal tools for both personal and professional contexts. The methodology combines a comparative analysis of current-generation devices, a review of technical specifications from manufacturer documentation, and case studies of specialized deployments, particularly in medical diagnostics, remote monitoring, and workplace efficiency. Project findings will indicate the rate at which wearable devices are moving beyond consumer fitness tracking and …

A Comparative Analysis Of Complete Streets And Multimodal Transport Approaches: Implications For Sustainable Urban Mobility In Lincoln, And Global Contexts, Oliva Richard Kilyenyi

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Movement of people and goods in urban areas through different modes of transportation including walking, cycling, public transit and by autos is termed as urban mobility. Urban mobility presents significant environmental, social, and economic challenges for cities worldwide as they grapple with the impacts of conventional transportation systems, particularly in North America context where car-centric planning approaches has dominated urban developments since 1950s. Car-centric dominance is 80% in North American Metropolitan areas (Manaugh et al., 2015). The impacts of these conventional systems include greenhouse gas emission emissions contributing approximately 24% of global carbon dioxide (CO₂) emissions, air pollution …

Cattlefever: An Automated Cattle Fever Estimation System, Trong Thang Pham, Ethan Coffman, Beth Kegley, Jeremy G. Powell, Jiangchao Zhao, Ngan Le

Electrical Engineering and Computer Science Faculty Publications and Presentations

Farmers face the critical challenge of monitoring cattle well-being for both ethical and economic success, relying on signals like body temperature and facial expressions to assess their animals' health. However, these indicators have traditionally relied on human observation with manual measurement, which is time-consuming and subjective. Despite this clear need, no automated system currently exists for monitoring cattle body temperature, and available datasets remain limited in scope. To address these challenges, we make two key contributions: (i) We introduce CattleFace-RGBT, a novel RGB-Thermal (RGB-T) Cattle Facial Landmark dataset consisting of 2,300 paired RGB and thermal images (4,600 images in total), …

Multi-Criteria Decision-Making For Sustainable Design: Stakeholder Prioritization And Methodological Comparison In Solar And E-Bike Applications, Swagath Madhu Gowda

All Theses

This thesis focuses on using Multi-Criteria Decision-Making (MCDM) methods to support sustainable product design by addressing the trade-offs between environmental, economic, and social goals. The research is presented through two studies that demonstrate how both subjective and objective decision-making approaches can guide sustainability evaluations.

The first study applies the Analytic Hierarchy Process (AHP) to assess residential solar panels by incorporating stakeholder perspectives from sustainability experts, end users, and industry professionals. Using Life Cycle Sustainability Assessment (LCSA) data, this study identifies how different stakeholder groups prioritize sustainability criteria and applies Aggregation of Individual Priorities (AIP) to combine their judgments. A one-at-a-time …

Optimal Network Maintenance And Restoration: Applications And Algorithms, Nayan Chakrabarty

Graduate Theses and Dissertations

In this dissertation, we consider three types of network optimization problems. In Chapter 1, we consider a network maintenance problem which focuses on time-based redeployment of multi-class nodes for reliable wireless sensor network coverage. Whereas previous research on time-based node redeployment assumes nodes are identical with respect to time to failure, we use multiple classes of sensor nodes to represent a scenario where nodes’ times to failure are dependent on positioning in the network. We propose a partial survival signature (PSS) approach for estimating area coverage reliability under a given time-based redeployment policy, where the PSS is estimated by Monte …

Evaluating Psychosocial Stressors And Mental Well-Being Of Construction Professionals From The Management Standpoint: An Exploratory Study, Md Tauhidul Karim

Masters Theses

Construction professionals face persistent workplace stressors that undermine their mental well-being outcomes. Despite progress in general job-related stressors, social and interpersonal aspects of psychosocial stressors traditionally remain underexplored in the construction management research. The present study examines how social and interpersonal factors influence construction workers’ mental well-being and how management’s awareness, responsiveness, and strategic roles evolved in the transition of the COVID-19 pandemic at the organizational level. An integrative mixed-methods approach was employed, combining a systematic literature review, a bibliometric analysis, and an exploratory case study to capture the current landscape of mental well-being and management standpoints in the US …

The Iron Pyramid: Expanding The Iron Triangle To Integrate Safety As A Fundamental Dimension Of Construction Success, Laura Cooley

All Theses

For more than fifty years, construction project success has been judged by staying on schedule, remaining within budget, and completing the planned scope of work—an approach commonly known as the “Iron Triangle” (Barnes, Ph.D., 2006). While these measures are important, they do not capture the full range of factors that determine whether a project truly succeeds.

This study introduces the “Iron Pyramid” (Cooley, 2025), a model that expands the traditional framework by adding a fourth dimension: safety. Safety is understood not simply as regulatory compliance or the absence of injuries, but as a holistic construct encompassing project culture, leadership practices, …

Digital Solutions For Bridging Language Barriers: Designing And Testing An App For Construction Spanish Safety Communication On Construction Jobsites, Adrian Cappella

All Theses

Language barriers between English-speaking supervisors and Spanish-speaking workers create safety risks on U.S. construction jobsites. Hispanic workers face higher injury and fatality rates, with miscommunication being a major contributing factor. Existing translation tools lack the accuracy, cultural context, and jobsite relevance needed for effective safety communication.

In this study a mobile application with construction-specific safety phrases in English and Spanish was designed and field tested. The research included a literature review, phrase collection and validation with industry experts, application development and design with a computer science collaborator, and usability testing with supervisors and workers. Surveys and field trials measured navigation, …

Effective Transfer Of Tumor Annotations From Hematoxylin And Eosin To Fluorescence Images Of Breast And Lung Tissues, Tianling Niu, Emi Ampo, Julie M. Jorns, Mollie Patton, Tongtong Lu, Dong Hye Ye, Tina Yen, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance: Accurate transfer of annotations from histological images to fluorescence images is essential in developing deep learning (DL)-based optical imaging systems for intraoperative assessment of tumor margins. Manual annotation is time-consuming, prone to interobserver variability, and impractical for large-scale datasets.

Aim: We present a semi-automated method that can effectively transfer tumor annotations from pathologist-annotated hematoxylin and eosin (H&E) images to fluorescence images captured using microscopy with ultraviolet surface excitation (MUSE). This method is not intended for intraoperative use but rather to facilitate the creation of annotated datasets for DL model development.

Approach: Our semi-automated method consists of nonrigid image registration, …

Method To Measure Blast Overpressure Exposure On Military Personnel Using Orthogonal Sensor Orientations, Nicholas W. Kuehl, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

Measuring and recording blast exposure to military personnel from shoulder-fired weaponry or improvised explosive devices to correlate health outcomes like mild traumatic brain injury has been a goal for many years. To ensure overpressure is recorded, sensor manufacturers either recommend multiple sensors on different parts of the body or have integrated multiple sensors into one unit. Despite this, knowing the sensor orientation in relation to the blast source is important to know if it's a head on, side on or oblique pressure recording. This research investigates whether pressures recorded at three independent orientations in the x, y and z planes …

Design And Development Of A Multi-Port Solid State Circuit Breaker Based On Half Bridge Sic Mosfets, Yannal Nawafleh

Graduate Theses and Dissertations

This thesis investigates multi-port solid-state circuit breaker (M-SSCB) architectures that reduce steady-state conduction losses while preserving microsecond-class DC fault interruption and per-port selectivity. The proposed M-SSCB consolidates protection for several node interfaces into a single assembly with shared sensing, control, and a common energy-absorption branch. In normal operation, two electrically symmetric parallel semiconductor paths are established so each port’s current divides approximately in half; because conduction loss scales with current squared, the M-SSCB achieves ≈75% reduction in on-state loss relative to a conventional anti-series SiC path without increasing device count. During fault handling, the coordinated controller detects the local over-current, …

Solar Powered Conservation: The Effects Of Solar Photovoltaic Facilities On Avian Community Composition, Michael Christopher Ferrara

Graduate Theses and Dissertations

The expansion of solar photovoltaic energy infrastructure is transforming landscapes worldwide. Increasingly, facilities are planted with native vegetation, yet how vegetation characteristics and landscape variables shape wildlife communities in solar facilities remains poorly understood. Because avian populations have been in decline and are sensitive to habitat changes, understanding how solar facilities influence avian communities is important. In Chapter 1, we used autonomous recording units, local vegetation measurements, and land use and land cover data to quantify how avian community occupancy is influenced by solar cover in solar facilities and comparable reference sites. We used a Bayesian multi-species occupancy model to …

Volume Status Detection With Integral Pulse Frequency Modulation Model Of Peripheral Venous Pressure, Jeremiah Rhys Wimer

Graduate Theses and Dissertations

This thesis studies the effectiveness of utilizing a modified integral pulse frequency modulation (IPFM) algorithm to synthesize peripheral venous pressure (PVP) waveforms for the detection of several physiological conditions using logistic regression. PVP waveforms are collected from 18 human patients and 4 porcine subjects. Human data are used to train models for determining the hypovolemic status of the patient, while the porcine data are used to train models for determining level of anesthesia and detecting internal hemorrhaging. In the human dataset, the waveforms collected from the 18 patients are classified into two groups according to serum chloride levels: resuscitated (≥100 …