Digital Commons Network^™

Ƒ(Cell): Software For Reproducible Analysis Of Optoretinograms, Robert F. Cooper, Mina Gaffney, Brea D. Brennan, Niko Rios

Biomedical Engineering Faculty Research and Publications

Purpose: There has been a marked increase in use of a noninvasive functional imaging technique called optoretinography (ORG). As more groups use ORGs, it is crucial to have a consistent methodology, and understand what analysis parameters influence repeatability. In this work, we present an open-source software library called ƒ(Cell) designed to facilitate reproducible and repeatable analyses of ORG data.

Methods: We designed ƒ(Cell) as a Python software library that can co-register and analyze ORG datasets, while also enabling process auditing. To validate the software, we used our previously obtained normative optoretinography datasets as well as datasets from six …

Thousand Hills Pet Resort Ada Compliant Access Ramp And Connecting Deck: Preconstruction Activities, Sonya Nahama Wijoyo

Construction Management

This paper presents the design and preconstruction of an ADA-compliant access ramp and connecting deck system for two mobile homes located at Thousand Hills Pet Resort. The primary objective was to enhance accessibility and safety for residents by providing code-compliant, durable, and functional access to the mobile homes on site. This project is interdisciplinary between construction management and architectural engineering. The project began with a site evaluation to assess existing conditions. Field measurements and site observation guided planning decisions and helped identify potential challenges. Following the site evaluation, the project proceeded into the design phase, where the ramp and deck …

Design And Tissue Engineering Applications Of Microporous Annealed Particle (Map) Scaffolds, Nic D. Leipzig, Oluwaseyi Shofolawe-Bakare

University Research

Microporous annealed particle (MAP) scaffolds are emerging as a facile, yet sophisticated biomaterial platform with tremendous potential for tissue regenerative applications. These scaffolds are fabricated in situ through interparticle crosslinking of microgels using a variety of covalent or non-covalent techniques and possess excellent tunability and biocompatibility. The microporous structure of MAP scaffolds allows cellular infiltration and vascularization independent of degradation rate, making them more advantageous than traditional nanoporous bulk hydrogels. Moreover, the incorporation of in situ crosslinking allows MAP scaffolds to retain the key advantages of traditional microgel-based scaffolds—such as injectability and modularity—while providing the added benefit of a fixed …

Design And Development Of A 12-Degree-Of-Freedom Quadruped Robot, Kai De La Cruz

Master's Theses

This thesis presents the design, analysis, and experimental validation of a 12-degree-of-freedom (DOF) quadruped robot developed as a research platform for legged locomotion and control. The system builds upon the Cal Poly Legged Robotics Group’s prior 8-DOF quadruped, addressing key limitations in manipulability, load distribution, and mechanical robustness by introducing a 3-DOF leg architecture.

The mechanical design emphasizes lightweight construction, structural integrity, and modularity to support future research extensions. Static and dynamic loading models were developed to inform component sizing and material selection. A carbon-fiber chassis and redesigned leg assemblies were fabricated and validated through finite element analysis and physical …

Globalizing The Engineering Job Market: Optimizing Engineering Career Expos To Serve International Students, Hailey A. Hesseltine

Journal of Global Education and Research

As the United States hosts approximately one million international students annually, it becomes imperative that on-campus resources are tailored to meet the needs of this diverse student population. One on-campus resource that is crucial to student success is career services, especially considering the aspirations of many international students to secure employment post-graduation. To address this, this study aimed to understand the satisfaction levels of international engineering students with an engineering career expo in Hawaiʻi. Utilizing a combination of surveys and interviews using a neo-racism framework, international students shared their experiences from the career expo through discussion and assessment. Information given …

Improving Cellular Retention And Distribution To Promote Arteriogenesis In A Mouse Model Of Chronic Arterial Occlusion, Nancy Huang

Biomedical Engineering

Peripheral Arterial Occlusive Disease (PAOD) affects millions of people in the United States, creating pain, discomfort, and limited mobility due to restricted blood flow from obstructed arteries. While current treatments include lifestyle changes and revascularization procedures, these options are often insufficient or inaccessible because of procedural pain and socioeconomic barriers. In some cases, this can lead to critical limb ischemia and amputation as a last resort. Increasing blood flow to the extremities by enhancing collateral vessel growth, a biological process called arteriogenesis, with cell-based therapies can redirect blood flow around obstructions and has potential to mitigate and treat the effects …

Orthopedic Bone Drill, Logan G. Schmid, Matthew T. Wold, May Geng

Biomedical Engineering

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during drilling.

Elevating The Underrepresented And Marginalized Using Experiences In Stem (Lumens): A Stem Diversity And Inclusion Initiative, Robert Cobb Jr, Paula E. Faulkner, Deiadra Modlin, Obinna Chiekezi, Victoria Cobbold, Madison Beaudoin

Journal of Research Initiatives

The study offered a 5-week summer immersion program to address the shortage of students from underrepresented populations enrolling in degree programs and seeking careers in science, technology, engineering, and mathematics (STEM). The study also addressed the importance of offering summer immersion programs to close the achievement gap. A quantitative descriptive design was used to gather data from participants related to STEM lessons during the program. Gender, grade level, and race served as the demographic variables. The study included 21 secondary students in grades 9–12. Pre- and post-tests assessed participants' knowledge gain regarding STEM lessons. Data analyzed with SPSS version 29 …

Navigation Beyond Wayfinding: Robots Collaborating With Visually Impaired Users For Environmental Interactions, Shaojun Cai, Nuwan Janaka, Ashwin Ram, Janidu Shehan, Yingjia Wan, Kotaro Hara, David Hsu

Research Collection School Of Computing and Information Systems

Robotic guidance systems have shown promise in supporting blind and visually impaired (BVI) individuals with wayfinding and obstacle avoidance. However, most existing systems assume a clear path and do not support a critical aspect of navigation—environmental interactions that require manipulating objects to enable movement. These interactions are challenging for a human–robot pair because they demand (i) precise localization and manipulation of interaction targets (e.g., pressing elevator buttons) and (ii) dynamic coordination between the user’s and robot’s movements (e.g., pulling out a chair to sit). We present a collaborative human–robot approach that combines our robotic guide dog’s precise sensing and localization …

N-Dqn: Neutrosophic Deep Q-Network For Uncertainty-Aware Forecasting And Decision Optimization, Rania Lutfi

Neutrosophic Systems with Applications

Uncertainty remains a critical challenge in dynamic spatiotemporal forecasting. This study proposes the Neutrosophic Deep Q-Network (N-DQN), a framework that integrates neutrosophic logic with deep reinforcement learning to enhance decision optimization under uncertainty. Features are modeled through truth, indeterminacy, and falsity membership functions, enabling robust handling of ambiguous data. The framework incorporates attention-guided preprocessing and horizon-aware optimization to adapt predictions across short- and long-term intervals. Experiments on benchmark traffic datasets (METR-LA and PEMS-BAY) demonstrate improved forecasting accuracy and reduced error rates compared with established baselines. The results highlight the scalability and resilience of N-DQN, positioning it as a promising approach …

Single-Valued, Double-Valued, Triple-Valued, Quadruple-Valued, And Quintuple-Valued Neutrosophic Graph, Takaaki Fujita, Arif Mehmood, Arkan A. Ghaib

Neutrosophic Systems with Applications

Concepts such as fuzzy sets, neutrosophic sets, rough sets, and plithogenic sets have been extensively studied as formal tools for modeling uncertainty, and they have found broad applications across many disciplines. A Double-Valued Neutrosophic Set (DVNS) extends the classical neutrosophic framework by splitting indeterminacy into two distinct components: one leaning toward truth and the other leaning toward falsity. In recent years, further refinements—namely Triple-Valued, Quadruple-Valued, and Quintuple-Valued Neutrosophic Sets—have also been introduced and investigated. These uncertainty models have naturally been lifted to graph-theoretic settings, where vertices and edges represent entities and relationships under ambiguity. Although fuzzy graphs and neutrosophic graphs …

Evaluating Domains' Trustworthiness Based On Uncertainty-Driven Methodologies In The Era Of Sixth Generation, Zekra Sakr, Mona Mohamed

Neutrosophic Systems with Applications

The onset of today's innovations pledges to have a beneficial influence on contemporary civilization in an era of intelligent revolutions, setting a precedent for unrivaled efficiency, creativity, and connectedness. The integration between these technologies contributes to the mutual benefit of each one, wherein this relation is a so-called ``reciprocal partnership''. For instance, the sixth generation (6G) wireless networks permit blockchain nodes to coordinate huge volumes of transaction data in real-time. On the other hand, blockchain is considered a secure valve because spectrum sharing can be automated with blockchain and smart contracts. Accordingly, analyzing and evaluating the contribution of these technologies …

Neutrosophic Finsler–Cohomological Framework For Engineering Systems Under Uncertainty, Mona Gharib, Ghulam Muhammad, Muhammad Idrees, Zeeshan Gul

Neutrosophic Systems with Applications

This paper introduces a novel mathematical framework that combines Neutrosophic Finsler Geometry with Neutrosophic Cohomology for evaluating the performance of Brushless Direct Current (BLDC) motors under uncertain and indeterminate operating conditions. Classical motor performance models typically assume precise measurements of torque, current, and efficiency; however, in real-world settings, these parameters are often affected by noise, incomplete information, and conflicting observations. By embedding motor operating states into a neutrosophic Finsler space, the proposed approach captures variations not only in magnitude but also in direction, uncertainty, and conflict of performance metrics. In addition, neutrosophic Cohomology is employed to characterize global invariants of …

Nanoscale Opportunities In Extracellular Matrix Mimicry, L. Andrew Lyon, Abbygail Caine, Elif Narbay, E. Daniel Cárdenas-Vásquez

Engineering Faculty Articles and Research

We present an overview of the composition, function, energetics, and dynamics of extracellular matrix and its relation to nanoscale structures and phenomena. These concepts are then related to the development of synthetic and biosynthetic materials that aim to mimic the extracellular matrix for regenerative medicine and tissue engineering technologies. Notable successes and advancements towards the goal of biomimicry are outlined, while remaining challenges and knowledge gaps towards that goal are highlighted. Finally, we frame the remaining challenges in the field in terms of nanoscience-related research opportunities that if solved, might prove to be transformative steps forward in the discipline.

Improving The Uv Resistance And Service Life Of Polystyrene-Based Building Materials Via Low-Concentration Metal Complex Modifiers, Dina S. Ahmed, Marwa Fadhil, Raghda Alsayed, Mohammed Kadhom, Muna Bufaroosha, Amani Husain, Thura Alyasiri, Hanan Ibraheem, Alaa A. Rashad, Bassam M. Abood, Riyadh Noaman, Ahmed Ahmed, Ruqaya Raad, Ala'a Shaker, Abeer Erfan, Hassan Hashim, Saba Hamza, Rahimi M. Yusop, Emad Yousif

AUIQ Technical Engineering Science

PS is highly susceptible to UV-induced photodegradation, which results in deterioration of its mechanical and aesthetic properties. In the present study, four novel and highly aromatic levofloxacin metal complexes, synthesized from Zn, Sn, Cu, and Ni, were investigated as low-concentration (0.5% w/w) photostabilizer additives for PS. Composite films were prepared by solution casting and subjected to accelerated UV irradiation up to 300 hours. Photostabilizing performance was systematically followed by monitoring changes in the carbonyl index via FT-IR spectroscopy, mass loss measurements, and surface morphology analyses using SEM and AFM. Results showed that all levofloxacin metal complexes had a pronounced inhibition …

Tetramethylbenzidine Loaded Pva Nanofibers Strip For Visual Detection Of Hydrogen Peroxide Via Cu2+ Catalysis And Its Applications, Samar A. Salim

Nanotechnology Research Centre

Background Advancements in sensor technology have facilitated the development of cost-effective and highly sensitive sensors which have significantly improved the detection of biological analytes in various fields. This study presents a novel approach for the detection of hydrogen peroxide (H₂O₂), a critical analyte in both biological and environmental systems. A simple and sensitive colorimetric sensing platform was developed based on polyvinyl alcohol (PVA) nanofibers loaded with tetramethylbenzidine (TMB). Results The nanofibers were characterized using scanning electron microscopy, confirming the formation of smooth, spindle-shaped fibers with diameters from 324 to 551 nm. The colorimetric detection method utilized TMB, which undergoes oxidation …

Uas Path Planning With Dynamic Rerouting Using A Space-Time Graph, Kimoy Williams

Electronic Theses and Dissertations 2020 - Present

UAS systems have emerged as multifaceted technologies with applications across a wide range of sectors. Their ability to access areas that are difficult or unsafe for manned systems has made them invaluable tools in various domains. As a result, UAS have transformed numerous industries, including infrastructure inspection, delivery and logistics, military and defense, as well as precision agriculture and environmental monitoring.

The advancement in UAS technology is fundamentally reliant upon ongoing research efforts in the specialized area of UAS path planning. Optimal flight planning is essential for a UAV to effectively execute its mission’s task safely, effectively, and in congruence …

Trusted Forms—The Case Of Barack Obama’S Birth Certificate, Karl-Heinrich Schmidt, Frederik Schlupkothen

Proceedings from the Document Academy

Documents can be understood as containers for information that enable remote communication between people across space and time. They are therefore fundamentally subject to issues of trust. The theoretical treatment of documents as a means of remote communication has a long history and has arrived in the age of electronic document exchange, as shown by the work of R. T. Pédauque, which is taken as a starting point here.

To take theory further, form-based documents are discussed here as an example. Form-based documents control the information provided by fillers by specifying form fields. The core of this paper is to …

Seismic Behavior Of Slender Cable-Supported Braced Frame Structures, Aya Aboelnaga, Mohamed Mortagi, Mohamed E. El Madawy, A.H.A. Abdelrahman, M. Naguib

Mansoura Engineering Journal

This research investigates advanced strategies to enhance the seismic performance and global stability of slender steel frames by integrating cable-supported and braced systems. To address these challenges, the study develops finite element (FE) models of multi-story slender frames in SAP2000, incorporating both cable-supported configurations and diagonal bracing systems. Nonlinear time-history analyses are performed using selected earthquake ground motions to evaluate structural response, inter-story drift, and mode shape behavior. Results highlight the efficiency of cablesupported frames in controlling lateral displacements and redistributing forces, while also emphasizing the role of bracing in providing additional stiffness. The findings demonstrate that guided frames with …

Mechanized Tube Well Installation, Robert M. Stwalley Iii, Grace L. Baldwin Kan-Uge, Roger Tormoehlen

Purdue University Press Books

Mechanized Tube Well Installation provides detailed information on the design development of a mechanized means to install shallow tube wells using a hydraulic driver attached to a small vehicle. This book explores the creation of this technique through the merging of available components, selection of the components, testing of the assembly, and the driving of wells. It also provides comprehensive coverage of state-of-the-art engineering, technology, and best practices as they relate to driving water wells for human consumption, animal care, and irrigation. Mechanized Tube Well Installation is well-aligned with collegiate humanitarian aid, environmental and natural resources engineering, and agricultural equipment …

Intravascular Ultrasound Is More Accurate Than Angiography In Arteriovenous Vascular Access Lesions, James W. Decker, Dima Banihani, Curtis Honshideler, Saran Lotfollahzadeh, David Jasen Wu Wong, Alik Farber, Jeffrey J. Siracuse, Najia Idrees, Laura Dember, Mohammad Bader, Suvranu Ganguli, Vijaya Kolachalama, Tarek Shazly

Faculty Publications

Background:

Conventional angiography remains the standard diagnostic modality for arteriovenous (AV) access dysfunction in hemodialysis patients, but its geometric accuracy is limited. Intravascular ultrasound (IVUS) offers superior lesion detection, yet its absolute measurement accuracy remains uncertain. Using three-dimensional (3D) printed vascular conduits as reference standards, we assessed the accuracy of IVUS versus angiography, hypothesizing that complex conduit geometry, quantified by Gaussian curvature, would exacerbate angiographic error.

Methods

Clinically relevant AV access geometries were modeled with computer-aided design (CAD) and fabricated using 3D printing. Lumen diameters were measured by contrast angiography and IVUS and compared with CAD dimensions. Conduit geometry was …

Solar Backscatter Ultraviolet (Buv) Retrievals Of Mid-Stratospheric Aerosols From The 2022 Hunga Eruption, Robert J.D. Spurr, Matt Christi, Nickolay A. Krotkov, Won Ei Choi, Simon Carn, Can Li, Et Al.

Michigan Tech Publications

On 15 January 2022, a highly explosive eruption of the submarine Hunga volcano (Kingdom of Tonga) generated the largest stratospheric hydration event ever observed and the largest aerosol perturbation since the 1991 Pinatubo eruption. Here, we develop a novel method for satellite retrieval of stratospheric aerosol optical depth (AOD) and layer peak height (zp) using solar backscattered ultraviolet (BUV) radiation; this is made possible by the exceptional mid-stratospheric altitude of the Hunga aerosols. We analyze BUV observations of the Hunga stratospheric aerosol cloud on 17 January 2022 (47 h after the eruption), using BUV band 1 measurements from the TROPOspheric …

A Comprehensive Review Of Food Waste Management In Attaining Sdg 12.3 Goals: Insights From Asian Countries, Ping Hu, Lotifa Tamanna Toma, Ashraful Alam, Md. Tanvir Ahmmed, Md. Jahidul Islam, Kazi Farhana, Marjia Sultana, Miraj Ahmed Bhuiyan

Civil and Environmental Engineering Faculty Publications and Presentations

Food waste is one of the most important world-wide challenges whose environmental, economic and social impacts have far-reaching effects that include contributing to greenhouse gas emissions, resources depletion as well as the rising levels of food insecurity. These problems are further intensified in Asia due to high rate of urbanization, population growth, changing dietary habits, and lack of waste management facilities. These conditions complicate the fact that countries are increasingly struggling to achieve the United Nations Sustainable Development Goal (SDG) 12.3, which is to ensure that by 2030, half of the world has dropped per-capita food waste, and food losses …

Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser

Faculty Publications

Snapping shrimp damp the shock waves they produce and use as weapons with a helmet-like structure termed the orbital hood. Here, we ask how structural and material properties contribute to shock wave damping by orbital hoods in Alpheus heterochaelis. Using tensile mechanical testing, we find orbital hoods are approximately half as stiff as carapace and have twice the capacity for viscous energy dissipation. Microstructural features probably contribute to tissue-specific mechanical properties: the endocuticles of orbital hoods have almost twice as many lamellae as those of carapaces despite being half as thick, suggesting a mechanism for enhanced material mobility underlying …

Computational Investigation Of Cavitation Inception In Centrifugal Pumps, Mohamed Ibrahim Eldesouky, Asmaa Khater, Abdel-Rahim Dohina, Mohamed Rabie

Mansoura Engineering Journal

This study examines the effects of suction chamber baffle configurations on both hydraulic efficiency and cavitation characteristics in a low specific speed centrifugal pump. Four baffle configurations (zero, one, two, and three baffles) were tested at three different heights using refined computational fluid dynamics simulations. The Zwart-Gerber-Belamri cavitation model was enhanced by adjusting nucleation site radius and evaporation coefficient values to better align with previous research findings. Results revealed that the optimal baffle height is approximately one-third of the impeller suction eye radius, significantly improving cavitation resistance. Under non-cavitation conditions, all baffled configurations outperformed the no-baffle setup, with a single …

Diverse Enteric Bacterial, Viral, And Parasitic Pathogen Genes Are Shed In Animal Feces In Indiana, Anna A. Heintzman, Ishi Keenum, Drew Capone

Michigan Tech Publications

Southern Indiana has intensive livestock production, yet species-resolved fecal pathogen and pathogen associated gene profiles are limited. At 10 sites in southern Indiana (April-June 2024), we collected 128 fecal specimens from 10 hosts: pigs (n=12), horses (12), cats (12), chickens (12), dogs (22), white-tailed deer (12), sheep (12), goats (12), cows (12), and humans (10). We extracted and assayed total nucleic acids using a custom 43-target TaqMan Array Card (RT-qPCR). Flotation microscopy was performed on pig and dog stools for helminth ova. In-silico specificity checks were conducted for selected targets due to potential for cross reactivity between pathogen species. Most …

Electromagnetic Simulations For Vulnerable Road User Safety In 5g/6g Wireless Systems, Colin Mcnerny

Theses and Dissertations

Protecting vulnerable road users is imperative. As 5G wireless technology matures and 6G standards are established, new operational technology emerges to reduce traffic accidents. There is widespread evidence to support the need for pedestrian awareness in modern traffic ecosystems as a significant number of vulnerable road users are injured or killed every year due to observable traffic failures. Computational electromagnetic (CEM) solvers are used to model, simulate, and analyze the performance of antennas deployed to meet this challenge. Validation studies using the Altair FEKO CEM solver demonstrate scenarios where vulnerable road users are at risk. The simulation data in this …

Print, Pattern, Stick: Low–Cost Gecko–Inspired Adhesives Using Embedded Diffraction Structures, Motaz Hassan, Oluwafemi Fayomi, Ajay Mahajan, Joshua Faust

University Research

Gecko-inspired adhesives offer strong, reversible, and directionally tunable adhesion, yet fabrication methods often depend on cleanroom lithography or proprietary molds, limiting scalability and accessibility. This study presents a low-cost, modular fabrication strategy combining high-resolution digital light processing 3D printing with 1000 lines/mm optical diffraction gratings to create hierarchical elastomeric adhesives. The resulting structures feature macroscale micropillars and embedded sub-micron surface topography, enabling effective contact splitting without advanced microfabrication. Mechanical testing reveals a nonlinear increase in shear performance with contact area, with maximum shear forces exceeding 80 N at 103.2 cm2. Peel testing across varied angles and surface areas demonstrates anisotropic …

Challenges And Opportunities In Lentivirus Viral Vector Manufacturing For In Vivo Applications, Eduardo Barbieri, Caryn Heldt

Michigan Tech Publications

The clinical success of chimeric antigen receptor (CAR) T-cell therapies has revolutionized oncology, yet the high costs and logistical complexities of ex vivo manufacturing remain significant barriers to global patient access. In vivo cell therapy, which involves the direct injection of lentiviral vectors (LVVs) to engineer cells within the patient’s body, offers a promising, cost-effective alternative. However, transitioning from ex vivo to in vivo applications necessitates a fundamental shift in LVV biomanufacturing to ensure safety and efficacy. This paper examines the critical bottlenecks in the current LVV production landscape. In upstream processing, we explore LVV particle assembly and maturation mechanisms, …

Neuromodulation In Olfactory Networks: Inferring Circuit Motifs And Predicting Behavioral Outcomes From Neural Response Changes, Yelyzaveta Bessonova

McKelvey School of Engineering Graduate Student Theses & Dissertations

Many organisms rely on olfaction to navigate their environment in response to surrounding chemical cues. Within the olfactory system, first, external signals are transduced into neural activity patterns that drive a diverse array of behavioral responses. However, sensory processing alone does not fully account for this variability. Fluctuations in neuromodulator levels are equally critical in shaping how olfactory information is encoded and translated into behavior. The goal of this dissertation is to investigate how changes in the neurochemistry within the olfactory circuit influence neural signaling and, ultimately, behavioral responses. To achieve this, I investigated how three neuromodulators: serotonin, dopamine, and …